Last update:
Thu Nov 3 12:13:20 MDT 2022
Nicole LeBrasseur Loopy Sec61 mutants . . . . . . . . . . ??
Nicole LeBrasseur MITF links maturation and quiescence . . ??
Nicole LeBrasseur p107 Skps from S phase . . . . . . . . . ??
Nicole LeBrasseur Thinning microtubules . . . . . . . . . ??
Nicole LeBrasseur Freedom in condensation . . . . . . . . ??
William A. Wells Lengthening without letting go . . . . . ??
William A. Wells The oenocytes went 3 by 3 . . . . . . . ??
William A. Wells Exclusion is spreading . . . . . . . . . ??
William A. Wells Stretch but don't follow . . . . . . . . ??
William A. Wells One more C means no hearing . . . . . . ??
William A. Wells The discovery of synaptic vesicles . . . ??
William A. Wells Ribosomes, or the particles of Palade ??
William A. Wells A new take on the old . . . . . . . . . ??
William A. Wells Microsomes are the in vitro ER . . . . . ??
Ira Mellman Fifty years of cell biology . . . . . . 15
Tsanko S. Gechev and
Jacques Hille Hydrogen peroxide as a signal
controlling plant programmed cell death 17
Nasser M. Rusan and
Patricia Wadsworth Centrosome fragments and microtubules
are transported asymmetrically away from
division plane in anaphase . . . . . . . 21
Robin E. Bachelder and
Sang-Oh Yoon and
Clara Franci and
Antonio García de Herreros and
Arthur M. Mercurio Glycogen synthase kinase-3 is an
endogenous inhibitor of Snail
transcription . . . . . . . . . . . . . 29
Amy E. Loercher and
Elizabeth M. H. Tank and
Rachel B. Delston and
J. William Harbour MITF links differentiation with cell
cycle arrest in melanocytes by
transcriptional activation of INK4A . . 35
Danyang Chen and
Miroslav Dundr and
Chen Wang and
Anthony Leung and
Angus Lamond and
Tom Misteli and
Sui Huang Condensed mitotic chromatin is
accessible to transcription factors and
chromatin structural proteins . . . . . 41
Genevi\`eve Rodier and
Constantin Makris and
Philippe Coulombe and
Anthony Scime and
Keiko Nakayama and
Keiichi I. Nakayama and
Sylvain Meloche p107 inhibits G1 to S phase progression
by down-regulating expression of the
F-box protein Skp2 . . . . . . . . . . . 55
Zhiliang Cheng and
Ying Jiang and
Elisabet C. Mandon and
Reid Gilmore Identification of cytoplasmic residues
of Sec61p involved in ribosome binding
and cotranslational translocation . . . 67
Jhansi Kota and
Per O. Ljungdahl Specialized membrane-localized
chaperones prevent aggregation of
polytopic proteins in the ER . . . . . . 79
Juan Martin-Serrano and
Scott W. Eastman and
Wayne Chung and
Paul D. Bieniasz HECT ubiquitin ligases link viral and
cellular PPXY motifs to the vacuolar
protein-sorting pathway . . . . . . . . 89
Kai Stefan Dimmer and
Stefan Jakobs and
Frank Vogel and
Katrin Altmann and
Benedikt Westermann Mdm31 and Mdm32 are inner membrane
proteins required for maintenance of
mitochondrial shape and stability of
mitochondrial DNA nucleoids in yeast . . 103
Jiong Cao and
Jenni I. Viholainen and
Caroline Dart and
Helen K. Warwick and
Mark L. Leyland and
Michael J. Courtney The PSD95--nNOS interface . . . . . . . 117
Vsevolod Bodrikov and
Iryna Leshchyns'ka and
Vladimir Sytnyk and
John Overvoorde and
Jeroen den Hertog and
Melitta Schachner RPTP$ \alpha $ is essential for
NCAM-mediated p59$^{\rm fyn}$ activation
and neurite elongation . . . . . . . . . 127
Yuko Mimori-Kiyosue and
Ilya Grigoriev and
Gideon Lansbergen and
Hiroyuki Sasaki and
Chiyuki Matsui and
Fedor Severin and
Niels Galjart and
Frank Grosveld and
Ivan Vorobjev and
Shoichiro Tsukita and
Anna Akhmanova CLASP1 and CLASP2 bind to EB1 and
regulate microtubule plus-end dynamics
at the cell cortex . . . . . . . . . . . 141
Nathalie Sauvonnet and
Annick Dujeancourt and
Alice Dautry-Varsat Cortactin and dynamin are required for
the clathrin-independent endocytosis of
$ \gamma $ c cytokine receptor . . . . . 155
Rbiya S. Tuma Myo6 gets choosy . . . . . . . . . . . . ??
Rbiya S. Tuma A GTP signal to the nucleolus . . . . . ??
Rbiya S. Tuma Growth and trafficking . . . . . . . . . ??
Rbiya S. Tuma Actin-myosin tears it up . . . . . . . . ??
Rbiya S. Tuma Modeling distinct compartments . . . . . ??
William A. Wells Catching sight of lysosomes . . . . . . ??
William A. Wells The invention of freeze fracture EM and
the determination of membrane structure ??
Tom Misteli Going in GTP cycles in the nucleolus . . 177
Robert Y. L. Tsai and
Ronald D. G. McKay A multistep, GTP-driven mechanism
controlling the dynamic cycling of
nucleostemin . . . . . . . . . . . . . . 179
Frank Faulhammer and
Gerlinde Konrad and
Ben Brankatschk and
Sabina Tahirovic and
Andreas Knödler and
Peter Mayinger Cell growth-dependent coordination of
lipid signaling and glycosylation is
mediated by interactions between Sac1p
and Dpm1p . . . . . . . . . . . . . . . 185
Gabriella Dobrowolny and
Cristina Giacinti and
Laura Pelosi and
Carmine Nicoletti and
Nadine Winn and
Laura Barberi and
Mario Molinaro and
Nadia Rosenthal and
Antonio Musar\`o Muscle expression of a local Igf-1
isoform protects motor neurons in an ALS
mouse model . . . . . . . . . . . . . . 193
Wei-Lih Lee and
Michelle A. Kaiser and
John A. Cooper The offloading model for dynein function 201
Félix Machín and
Jordi Torres-Rosell and
Adam Jarmuz and
Luis Aragón Spindle-independent
condensation-mediated segregation of
yeast ribosomal DNA in late anaphase . . 209
Fabian Oceguera-Yanez and
Kazuhiro Kimura and
Shingo Yasuda and
Chiharu Higashida and
Toshio Kitamura and
Yasushi Hiraoka and
Tokuko Haraguchi and
Shuh Narumiya Ect2 and MgcRacGAP regulate the
activation and function of Cdc42 in
mitosis . . . . . . . . . . . . . . . . 221
Ulrich Kubitscheck and
David Grünwald and
Andreas Hoekstra and
Daniel Rohleder and
Thorsten Kues and
Jan Peter Siebrasse and
Reiner Peters Nuclear transport of single molecules 233
Daniel R. Croft and
Mathew L. Coleman and
Shuixing Li and
David Robertson and
Teresa Sullivan and
Colin L. Stewart and
Michael F. Olson Actin-myosin--based contraction is
responsible for apoptotic nuclear
disintegration . . . . . . . . . . . . . 245
Andrei I. Pozniakovsky and
Dmitry A. Knorre and
Olga V. Markova and
Anthony A. Hyman and
Vladimir P. Skulachev and
Fedor F. Severin Role of mitochondria in the pheromone-
and amiodarone-induced programmed death
of yeast . . . . . . . . . . . . . . . . 257
Reinhart Heinrich and
Tom A. Rapoport Generation of nonidentical compartments
in vesicular transport systems . . . . . 271
Stella Y. Lee and
Jia-Shu Yang and
Wanjin Hong and
Richard T. Premont and
Victor W. Hsu ARFGAP1 plays a central role in coupling
COPI cargo sorting with vesicle
formation . . . . . . . . . . . . . . . 281
Edward B. Lee and
Bin Zhang and
Kangning Liu and
Eric A. Greenbaum and
Robert W. Doms and
John Q. Trojanowski and
Virginia M.-Y. Lee BACE overexpression alters the
subcellular processing of APP and
inhibits A$ \beta $ deposition in vivo 291
Doris Meder and
Anna Shevchenko and
Kai Simons and
Joachim Füllekrug Gp135\slash podocalyxin and NHERF-2
participate in the formation of a
preapical domain during polarization of
MDCK cells . . . . . . . . . . . . . . . 303
Adam C. Martin and
Xiao-Ping Xu and
Isabelle Rouiller and
Marko Kaksonen and
Yidi Sun and
Lisa Belmont and
Niels Volkmann and
Dorit Hanein and
Matthew Welch and
David G. Drubin Effects of Arp2 and Arp3
nucleotide-binding pocket mutations on
Arp2/3 complex function . . . . . . . . 315
Emily Osterweil and
David G. Wells and
Mark S. Mooseker A role for myosin VI in postsynaptic
structure and glutamate receptor
endocytosis . . . . . . . . . . . . . . 329
Nicole LeBrasseur No vacuolar reunion . . . . . . . . . . ??
Nicole LeBrasseur BiP chaperones ER entry . . . . . . . . ??
Nicole LeBrasseur Yeast warfare . . . . . . . . . . . . . ??
Nicole LeBrasseur Neurons born in new places . . . . . . . ??
Nicole LeBrasseur Ring around the wound . . . . . . . . . ??
William A. Wells Saving varicella from suicide . . . . . ??
William A. Wells Thinner tubes . . . . . . . . . . . . . ??
William A. Wells Pore before seal . . . . . . . . . . . . ??
William A. Wells Kinetochores hold on with a ring . . . . ??
William A. Wells Development is easy . . . . . . . . . . ??
William A. Wells Cilia get arms for bending . . . . . . . 350
Jochen Reiter and
Eva Herker and
Frank Madeo and
Manfred J. Schmitt Viral killer toxins induce
caspase-mediated apoptosis in yeast . . 353
Natasha Pashkova and
Natalie L. Catlett and
Jennifer L. Novak and
Guanming Wu and
Renne Lu and
Robert E. Cohen and
Lois S. Weisman Myosin V attachment to cargo requires
the tight association of two functional
subdomains . . . . . . . . . . . . . . . 359
Joost Gribnau and
Sandra Luikenhuis and
Konrad Hochedlinger and
Kim Monkhorst and
Rudolf Jaenisch X chromosome choice occurs independently
of asynchronous replication timing . . . 365
Kerstin Bystricky and
Thierry Laroche and
Griet van Houwe and
Marek Blaszczyk and
Susan M. Gasser Chromosome looping in yeast . . . . . . 375
Nathan N. Alder and
Ying Shen and
Jeffrey L. Brodsky and
Linda M. Hendershot and
Arthur E. Johnson The molecular mechanisms underlying
BiP-mediated gating of the Sec61
translocon of the endoplasmic reticulum 389
Tracy J. LaGrassa and
Christian Ungermann The vacuolar kinase Yck3 maintains
organelle fragmentation by regulating
the HOPS tethering complex . . . . . . . 401
Alexandre G. Dayer and
Kathryn M. Cleaver and
Thamara Abouantoun and
Heather A. Cameron New GABAergic interneurons in the adult
neocortex and striatum are generated
from different precursors . . . . . . . 415
Hél\`ene A. Benink and
William M. Bement Concentric zones of active RhoA and
Cdc42 around single cell wounds . . . . 429
Hideki Yamaguchi and
Mike Lorenz and
Stephan Kempiak and
Corina Sarmiento and
Salvatore Coniglio and
Marc Symons and
Jeffrey Segall and
Robert Eddy and
Hiroaki Miki and
Tadaomi Takenawa and
John Condeelis Molecular mechanisms of invadopodium
formation . . . . . . . . . . . . . . . 441
Rosa Gonzalez-Quevedo and
Marina Shoffer and
Lily Horng and
Anthony E. Oro Receptor tyrosine phosphatase-dependent
cytoskeletal remodeling by the
hedgehog-responsive gene MIM/BEG4 . . . 453
Matthew Kirkham and
Akikazu Fujita and
Rahul Chadda and
Susan J. Nixon and
Teymuras V. Kurzchalia and
Deepak K. Sharma and
Richard E. Pagano and
John F. Hancock and
Satyajit Mayor and
Robert G. Parton Ultrastructural identification of
uncoated caveolin-independent early
endocytic vehicles . . . . . . . . . . . 465
Eva-Maria Damm and
Lucas Pelkmans and
Jürgen Kartenbeck and
Anna Mezzacasa and
Teymuras Kurzchalia and
Ari Helenius Clathrin- and caveolin-$1$--independent
endocytosis . . . . . . . . . . . . . . 477
Valérie Laurent-Matha and
Sharon Maruani-Herrmann and
Christine Prébois and
Mélanie Beaujouin and
Murielle Glondu and
Agn\`es Noël and
Marie Luz Alvarez-Gonzalez and
Sylvia Blacher and
Peter Coopman and
Stephen Baghdiguian and
Christine Gilles and
Jadranka Loncarek and
Gilles Freiss and
Françoise Vignon and
Emmanuelle Liaudet-Coopman Catalytically inactive human cathepsin D
triggers fibroblast invasive growth . . 489
Ying Wei and
Ralf-Peter Czekay and
Liliane Robillard and
Matthias C. Kugler and
Feng Zhang and
Kevin K. Kim and
Jian-ping Xiong and
Martin J. Humphries and
Harold A. Chapman Regulation of $ \alpha $5$ \beta $1
integrin conformation and function by
urokinase receptor binding . . . . . . . 501
Rabiya S. Tuma Lamellae lead the way . . . . . . . . . ??
Rabiya S. Tuma A stalled fork stalls recombination . . ??
Rabiya S. Tuma Another job for $ \beta $-catenin . . . ??
Rabiya S. Tuma Working up to the last minute . . . . . ??
Rabiya S. Tuma Severing saves microtubules . . . . . . ??
Nicole LeBrasseur Blood pressure and fertility . . . . . . ??
Nicole LeBrasseur Calcium says stop . . . . . . . . . . . ??
Nicole LeBrasseur Ribosome does it all . . . . . . . . . . ??
Nicole LeBrasseur Lumen cues calcium release . . . . . . . ??
Nicole LeBrasseur Supersensitive phospholipid sensing . . ??
William A. Wells Heterochromatin is late . . . . . . . . ??
William A. Wells The nucleolar origin of rRNA . . . . . . ??
William A. Wells A pathway for secretion . . . . . . . . 525
Nicole LeBrasseur and
Kendall Powell Cells in D.C.: The American Society for
Cell Biology . . . . . . . . . . . . . . 526
Martin Howard and
Karsten Kruse Cellular organization by
self-organization . . . . . . . . . . . 533
Peter Meister and
Angela Taddei and
Laurence Vernis and
Mickaël Poidevin and
Susan M. Gasser and
Giuseppe Baldacci Temporal separation of replication and
recombination requires the intra--S
checkpoint . . . . . . . . . . . . . . . 537
Xavier Saelens and
Nele Festjens and
Eef Parthoens and
Isabel Vanoverberghe and
Michael Kalai and
Frank van Kuppeveld and
Peter Vandenabeele Protein synthesis persists during
necrotic cell death . . . . . . . . . . 545
Kayoko Maehara and
Kimi Yamakoshi and
Naoko Ohtani and
Yoshiaki Kubo and
Akiko Takahashi and
Seiji Arase and
Nic Jones and
Eiji Hara Reduction of total E2F/DP activity
induces senescence-like cell cycle
arrest in cancer cells lacking
functional pRB and p53 . . . . . . . . . 553
Jennifer Y. Zhang and
Shiying Tao and
Robin Kimmel and
Paul A. Khavari CDK4 regulation by TNFR1 and JNK is
required for NF-$ \kappa $B-mediated
epidermal growth control . . . . . . . . 561
Brian Stramer and
Will Wood and
Michael J. Galko and
Michael J. Redd and
Antonio Jacinto and
Susan M. Parkhurst and
Paul Martin Live imaging of wound inflammation in
\bionameDrosophila embryos reveals key
roles for small GTPases during in vivo
cell migration . . . . . . . . . . . . . 567
Mojgan Padash Barmchi and
Stephen Rogers and
Udo Häcker DRhoGEF2 regulates actin organization
and contractility in the
\bionameDrosophila blastoderm embryo . . 575
Kevin C. Slep and
Stephen L. Rogers and
Sarah L. Elliott and
Hiroyuki Ohkura and
Peter A. Kolodziej and
Ronald D. Vale Structural determinants for EB1-mediated
recruitment of APC and spectraplakins to
the microtubule plus end . . . . . . . . 587
Katia J. Evans and
Edgar R. Gomes and
Steven M. Reisenweber and
Gregg G. Gundersen and
Brett P. Lauring Linking axonal degeneration to
microtubule remodeling by
Spastin-mediated microtubule severing 599
Laura Berliocchi and
Eugenio Fava and
Marcel Leist and
Volker Horvat and
David Dinsdale and
David Read and
Pierluigi Nicotera Botulinum neurotoxin C initiates two
different programs for neurite
degeneration and neuronal apoptosis . . 607
Stephanie L. Gupton and
Karen L. Anderson and
Thomas P. Kole and
Robert S. Fischer and
Aaron Ponti and
Sarah E. Hitchcock-DeGregori and
Gaudenz Danuser and
Velia M. Fowler and
Denis Wirtz and
Dorit Hanein and
Clare M. Waterman-Storer Cell migration without a lamellipodium 619
Nancy Gavert and
Maralice Conacci-Sorrell and
Daniela Gast and
Annette Schneider and
Peter Altevogt and
Thomas Brabletz and
Avri Ben-Ze'ev L1, a novel target of $ \beta $-catenin
signaling, transforms cells and is
expressed at the invasive front of colon
cancers . . . . . . . . . . . . . . . . 633
Sarah M. Short and
Alexandrine Derrien and
Radha P. Narsimhan and
Jack Lawler and
Donald E. Ingber and
Bruce R. Zetter Inhibition of endothelial cell migration
by thrombospondin-1 type-1 repeats is
mediated by $ \beta_1 $ integrins . . . 643
Dongren Yang and
Jesse Bierman and
Yukie S. Tarumi and
Yong-Ping Zhong and
Reshma Rangwala and
Thomas M. Proctor and
Yuko Miyagoe-Suzuki and
Shin'ichi Takeda and
Jeffrey H. Miner and
Larry S. Sherman and
Bruce G. Gold and
Bruce L. Patton Coordinate control of axon
defasciculation and myelination by
laminin-2 and -8 . . . . . . . . . . . . 655
Nicole LeBrasseur Cooperative kinesin . . . . . . . . . . ??
Nicole LeBrasseur Crossovers break SC symmetry . . . . . . ??
Nicole LeBrasseur Myristoylation versus SRP . . . . . . . ??
Nicole LeBrasseur Bringing PIPs to root tips . . . . . . . ??
Nicole LeBrasseur Nerve damage surveillance . . . . . . . ??
William A. Wells Bugs get decrepit too . . . . . . . . . ??
William A. Wells Chemotaxis by local steering . . . . . . ??
William A. Wells No exit for Ca$^{2+}$ . . . . . . . . . ??
William A. Wells Diet affects DNA . . . . . . . . . . . . ??
William A. Wells Bacteria keep oxygen flowing . . . . . . ??
William A. Wells How to spot a satellite cell . . . . . . ??
William A. Wells Autophagy unveiled . . . . . . . . . . . ??
William A. Wells How vessels become leaky . . . . . . . . 677
Jaideep Mathur Conservation of boundary extension
mechanisms between plants and animals 679
Kentaro Nabeshima and
Anne M. Villeneuve and
Monica P. Colaiácovo Crossing over is coupled to late meiotic
prophase bivalent differentiation
through asymmetric disassembly of the SC 683
Etsuko Muto and
Hiroyuki Sakai and
Kuniyoshi Kaseda Long-range cooperative binding of
kinesin to a microtubule in the presence
of ATP . . . . . . . . . . . . . . . . . 691
Yan He and
Franto Francis and
Kenneth A. Myers and
Wenqian Yu and
Mark M. Black and
Peter W. Baas Role of cytoplasmic dynein in the axonal
transport of microtubules and
neurofilaments . . . . . . . . . . . . . 697
Kunyoo Shin and
Sam Straight and
Ben Margolis PATJ regulates tight junction formation
and polarity in mammalian epithelial
cells . . . . . . . . . . . . . . . . . 705
Sabrina La Terra and
Christopher N. English and
Polla Hergert and
Bruce F. McEwen and
Greenfield Sluder and
Alexey Khodjakov The de novo centriole assembly pathway
in HeLa cells . . . . . . . . . . . . . 713
Martina Klee and
Felipe X. Pimentel-Muiños Bcl-X$_L$ specifically activates Bak to
induce swelling and restructuring of the
endoplasmic reticulum . . . . . . . . . 723
Sara Colombo and
Renato Longhi and
Stefano Alcaro and
Francesco Ortuso and
Teresa Sprocati and
Adriano Flora and
Nica Borgese N-myristoylation determines dual
targeting of mammalian NADH-cytochrome
b(5) reductase to ER and mitochondrial
outer membranes by a mechanism of
kinetic partitioning . . . . . . . . . . 735
Sergey N. Zolov and
Vladimir V. Lupashin Cog3p depletion blocks vesicle-mediated
Golgi retrograde trafficking in HeLa
cells . . . . . . . . . . . . . . . . . 747
Tatiana Boukh-Viner and
Tong Guo and
Alex Alexandrian and
André Cerracchio and
Christopher Gregg and
Sandra Haile and
Robert Kyskan and
Svetlana Milijevic and
Daniel Oren and
Jonathan Solomon and
Vivianne Wong and
Jean-Marc Nicaud and
Richard A. Rachubinski and
Ann M. English and
Vladimir I. Titorenko Dynamic ergosterol- and ceramide-rich
domains in the peroxisomal membrane
serve as an organizing platform for
peroxisome fusion . . . . . . . . . . . 761
Valeria Cavalli and
Pekka Kujala and
Judith Klumperman and
Lawrence S. B. Goldstein Sunday Driver links axonal transport to
damage signaling . . . . . . . . . . . . 775
Sang Yoon Lee and
Sergey Voronov and
Kresimir Letinic and
Angus C. Nairn and
Gilbert Di Paolo and
Pietro De Camilli Regulation of the interaction between
PIPKI$ \gamma $ and talin by
proline-directed protein kinases . . . . 789
Patrick Vincent and
Michael Chua and
Fabien Nogue and
Ashley Fairbrother and
Hal Mekeel and
Yue Xu and
Nina Allen and
Tatiana N. Bibikova and
Simon Gilroy and
Vytas A. Bankaitis A Sec14p-nodulin domain
phosphatidylinositol transfer protein
polarizes membrane growth of Arabidopsis
thaliana root hairs . . . . . . . . . . 801
Stephen J. Pratt and
Holly Epple and
Michael Ward and
Yunfeng Feng and
Vania M. Braga and
Gregory D. Longmore The LIM protein Ajuba influences p130Cas
localization and Rac1 activity during
cell migration . . . . . . . . . . . . . 813
Susanne tom Dieck and
Wilko D. Altrock and
Michael M. Kessels and
Britta Qualmann and
Hanna Regus and
Dana Brauner and
Anna Fejtová and
Oliver Bracko and
Eckart D. Gundelfinger and
Johann H. Brandstätter Molecular dissection of the
photoreceptor ribbon synapse . . . . . . 825
Rabiya S. Tuma Sticking to the nuclear envelope . . . . ??
Rabiya S. Tuma Exocytosis in small steps . . . . . . . ??
Rabiya S. Tuma Beating under pressure . . . . . . . . . ??
Rabiya S. Tuma Raf-1 regulates migration . . . . . . . ??
Rabiya S. Tuma Decondensation at the fork . . . . . . . ??
Nicole LeBrasseur Weakness as a strength . . . . . . . . . ??
Nicole LeBrasseur Acyl cycles move Ras . . . . . . . . . . ??
Nicole LeBrasseur Two vesicle pools for neurons . . . . . ??
Nicole LeBrasseur The learning matrix . . . . . . . . . . ??
Nicole LeBrasseur Cells do not relive youth . . . . . . . ??
William A. Wells Microtubules get a name . . . . . . . . 852
William A. Wells There's DNA in those organelles . . . . 853
Rose E. Goodchild and
William T. Dauer The AAA+ protein torsinA interacts with
a conserved domain present in LAP1 and a
novel ER protein . . . . . . . . . . . . 855
Paolo Paganetti and
Verena Calanca and
Carmela Galli and
Muriel Stefani and
Maurizio Molinari $ \beta $-site specific intrabodies to
decrease and prevent generation of
Alzheimer's A$ \beta $ peptide . . . . . 863
Yaniré N. Andrade and
Jacqueline Fernandes and
Esther Vázquez and
José M. Fernández-Fernández and
Maite Arniges and
Trinidad M. Sánchez and
Manuel Villalón and
Miguel A. Valverde TRPV4 channel is involved in the
coupling of fluid viscosity changes to
epithelial ciliary activity . . . . . . 869
Mark G. Alexandrow and
Joyce L. Hamlin Chromatin decondensation in S-phase
involves recruitment of Cdk2 by Cdc45
and histone H1 phosphorylation . . . . . 875
Yewei Liu and
William R. Randall and
Martin F. Schneider Activity-dependent and -independent
nuclear fluxes of HDAC4 mediated by
different kinases in adult skeletal
muscle . . . . . . . . . . . . . . . . . 887
Katy Schmidt and
Thorsten Schinke and
Michael Haberland and
Matthias Priemel and
Arndt F. Schilling and
Cordula Mueldner and
Johannes M. Rueger and
Elisabeth Sock and
Michael Wegner and
Michael Amling The high mobility group transcription
factor Sox8 is a negative regulator of
osteoblast differentiation . . . . . . . 899
Liang Xie and
Randall S. Johnson and
Robert S. Freeman Inhibition of NGF deprivation--induced
death by low oxygen involves suppression
of BIM$_{EL}$ and activation of HIF-1 911
Eijiro Yamada and
Shuichi Okada and
Tsugumichi Saito and
Kihachi Ohshima and
Minoru Sato and
Takafumi Tsuchiya and
Yutaka Uehara and
Hiroyuki Shimizu and
Masatomo Mori Akt2 phosphorylates Synip to regulate
docking and fusion of GLUT4-containing
vesicles . . . . . . . . . . . . . . . . 921
David A. Richards and
Jihong Bai and
Edwin R. Chapman Two modes of exocytosis at hippocampal
synapses revealed by rate of FM1-43
efflux from individual vesicles . . . . 929
Yoshihiko Shimizu and
Dean Thumkeo and
Jeongsin Keel and
Toshimasa Ishizaki and
Hiroko Oshima and
Masanobu Oshima and
Yoichi Noda and
Fumio Matsumura and
Makoto M. Taketo and
Shuh Narumiya ROCK-I regulates closure of the eyelids
and ventral body wall by inducing
assembly of actomyosin bundles . . . . . 941
Karin Ehrenreiter and
Daniela Piazzolla and
Vanishree Velamoor and
Izabela Sobczak and
J. Victor Small and
Junji Takeda and
Thomas Leung and
Manuela Baccarini Raf-1 regulates Rho signaling and cell
migration . . . . . . . . . . . . . . . 955
Kelsie M. Bernot and
Chang-Hun Lee and
Pierre A. Coulombe A small surface hydrophobic stripe in
the coiled-coil domain of type I
keratins mediates tetramer stability . . 965
Tadayuki Yago and
Jianhua Wu and
C. Diana Wey and
Arkadiusz G. Klopocki and
Cheng Zhu and
Rodger P. McEver Correction . . . . . . . . . . . . . . . 975
Nicole LeBrasseur Restraining spindles in distress . . . . ??
Nicole LeBrasseur Systematic import . . . . . . . . . . . ??
Nicole LeBrasseur Binding a bent integrin . . . . . . . . ??
Nicole LeBrasseur FGF gets in your bones . . . . . . . . . ??
William A. Wells TB bug inhibits any which way . . . . . ??
William A. Wells Split motifs . . . . . . . . . . . . . . ??
William A. Wells PML goes to the centrosome . . . . . . . ??
William A. Wells Ready, set, wait . . . . . . . . . . . . ??
William A. Wells Mice with no fat carriers are skinny . . ??
William A. Wells A cell line that is under control . . . 988
William A. Wells Defining junctional complexes . . . . . 989
Mike Rossner The NIH policy on enhancing public
access to publications resulting from
NIH-funded research . . . . . . . . . . 991
Francis A. Barr and
Johannes Egerer Golgi positioning . . . . . . . . . . . 993
Jeff Bachant and
Shannon R. Jessen and
Sarah E. Kavanaugh and
Candida S. Fielding The yeast S phase checkpoint enables
replicating chromosomes to bi-orient and
restrain spindle extension during S
phase distress . . . . . . . . . . . . . 999
Eva Kiesler and
Manuela E. Hase and
David Brodin and
Neus Visa Hrp59, an hnRNP M protein in Chironomus
and \bionameDrosophila, binds to exonic
splicing enhancers and is required for
expression of a subset of mRNAs . . . . 1013
Gregory Riddick and
Ian G. Macara A systems analysis of importin-$ \alpha
$--$ \beta $ mediated nuclear protein
import . . . . . . . . . . . . . . . . . 1027
Akira Honda and
Omayma S. Al-Awar and
Jesse C. Hay and
Julie G. Donaldson Targeting of Arf-1 to the early Golgi by
membrin, an ER--Golgi SNARE . . . . . . 1039
Wei Liu and
Rainer Duden and
Robert D. Phair and
Jennifer Lippincott-Schwartz ArfGAP1 dynamics and its role in COPI
coat assembly on Golgi membranes of
living cells . . . . . . . . . . . . . . 1053
Alka Mansukhani and
Davide Ambrosetti and
Greg Holmes and
Lizbeth Cornivelli and
Claudio Basilico Sox2 induction by FGF and FGFR2
activating mutations inhibits Wnt
signaling and osteoblast differentiation 1065
Hans-Georg König and
Donat Kögel and
Abdelhaq Rami and
Jochen H. M. Prehn TGF-$ \beta $1 activates two distinct
type I receptors in neurons . . . . . . 1077
Frank Henkler and
Eva Behrle and
Kevin M. Dennehy and
Andreas Wicovsky and
Nathalie Peters and
Clemens Warnke and
Klaus Pfizenmaier and
Harald Wajant The extracellular domains of FasL and
Fas are sufficient for the formation of
supramolecular FasL--Fas clusters of
high stability . . . . . . . . . . . . . 1087
Paola Defilippi and
Arturo Rosso and
Patrizia Dentelli and
Cristina Calvi and
Giovanni Garbarino and
Guido Tarone and
Luigi Pegoraro and
Maria Felice Brizzi $ \beta $1 integrin and IL-3R
coordinately regulate STAT5 activation
and anchorage-dependent proliferation 1099
Brian D. Adair and
Jian-Ping Xiong and
Catherine Maddock and
Simon L. Goodman and
M. Amin Arnaout and
Mark Yeager Three-dimensional EM structure of the
ectodomain of integrin $ \alpha $V$
\beta $3 in a complex with fibronectin 1109
Rabiya S. Tuma Mapping the checkpoint . . . . . . . . . ??
Rabiya S. Tuma ECM controls flow-induced NF-$ \kappa $B ??
Rabiya S. Tuma Glycolipids anchor laminin . . . . . . . ??
Rabiya S. Tuma Boundary proteomics . . . . . . . . . . ??
Rabiya S. Tuma Signal for ER-associated degradation . . ??
Nicole LeBrasseur Muscle cells take heart . . . . . . . . ??
Nicole LeBrasseur Folding in a crowd . . . . . . . . . . . ??
Nicole LeBrasseur APC proteolysis not overdone . . . . . . ??
Nicole LeBrasseur Orienting early cleavage . . . . . . . . ??
Nicole LeBrasseur DPP shapes up wing cells . . . . . . . . ??
Kendall Powell Coated pits bring in the yolk . . . . . 18
Kendall Powell Sugars sprinkled onto proteins in the
Golgi . . . . . . . . . . . . . . . . . 19
Atsushi Tamura and
Shojiro Kikuchi and
Masaki Hata and
Tatsuya Katsuno and
Takeshi Matsui and
Hisayoshi Hayashi and
Yuichi Suzuki and
Tetsuo Noda and
Shoichiro Tsukita and
Sachiko Tsukita Achlorhydria by ezrin knockdown . . . . 21
Yang Luo and
Glenn L. Radice N-cadherin acts upstream of VE-cadherin
in controlling vascular morphogenesis 29
Alan J. Tackett and
David J. Dilworth and
Megan J. Davey and
Michael O'Donnell and
John D. Aitchison and
Michael P. Rout and
Brian T. Chait Proteomic and genomic characterization
of chromatin complexes at a boundary . . 35
Geert J. P. L. Kops and
Yumi Kim and
Beth A. A. Weaver and
Yinghui Mao and
Ian McLeod and
John R. Yates and
Mitsuo Tagaya and
Don W. Cleveland ZW10 links mitotic checkpoint signaling
to the structural kinetochore . . . . . 49
Jessica B. Casaletto and
Leta K. Nutt and
Qiju Wu and
Jonathan D. Moore and
Laurence D. Etkin and
Peter K. Jackson and
Tim Hunt and
Sally Kornbluth Inhibition of the anaphase-promoting
complex by the Xnf7 ubiquitin ligase . . 61
Eric D. Spear and
Davis T. W. Ng Single, context-specific glycans can
target misfolded glycoproteins for
ER-associated degradation . . . . . . . 73
Alberto Marcelo Díaz Añel and
Vivek Malhotra PKC$ \eta $ is required for $ \beta $1$
\gamma $2/$ \beta $3$ \gamma $2- and
PKD-mediated transport to the cell
surface and the organization of the
Golgi apparatus . . . . . . . . . . . . 83
Catherine Gondcaille and
Marianne Depreter and
Stéphane Fourcade and
Maria Rita Lecca and
Sabrina Leclercq and
Pascal G. P. Martin and
Thierry Pineau and
Françoise Cadepond and
Martine ElEtr and
Nathalie Bertrand and
Alain Beley and
Sandrine Duclos and
Dirk De Craemer and
Frank Roels and
Stéphane Savary and
Maurice Bugaut Phenylbutyrate up-regulates the
adrenoleukodystrophy-related gene as a
nonclassical peroxisome proliferator . . 93
Nathan C. Jones and
Kristina J. Tyner and
Lisa Nibarger and
Heather M. Stanley and
Dawn D. W. Cornelison and
Yuri V. Fedorov and
Bradley B. Olwin The p38$ \alpha $ /$ \beta $ MAPK
functions as a molecular switch to
activate the quiescent satellite cell 105
Radhakrishnan Narayanan and
Marilyn Leonard and
Byeong Doo Song and
Sandra L. Schmid and
Mani Ramaswami An internal GAP domain negatively
regulates presynaptic dynamin in vivo 117
Ying Gu and
Ying Fu and
Peter Dowd and
Shundai Li and
Vanessa Vernoud and
Simon Gilroy and
Zhenbiao Yang A Rho family GTPase controls actin
dynamics and tip growth via two
counteracting downstream pathways in
pollen tubes . . . . . . . . . . . . . . 127
Cameron C. Scott and
Wendy Dobson and
Roberto J. Botelho and
Natasha Coady-Osberg and
Philippe Chavrier and
David A. Knecht and
Colin Heath and
Philip Stahl and
Sergio Grinstein Phosphatidylinositol-4,5- bis phosphate
hydrolysis directs actin remodeling
during phagocytosis . . . . . . . . . . 139
Tamara Golub and
Pico Caroni PI(4,5)P$_2$-dependent microdomain
assemblies capture microtubules to
promote and control leading edge
motility . . . . . . . . . . . . . . . . 151
Elena Zaitseva and
Aditya Mittal and
Diane E. Griffin and
Leonid V. Chernomordik Class II fusion protein of alphaviruses
drives membrane fusion through the same
pathway as class I proteins . . . . . . 167
Shaohua Li and
Patricia Liquari and
Karen K. McKee and
David Harrison and
Raj Patel and
Sean Lee and
Peter D. Yurchenco Laminin--sulfatide binding initiates
basement membrane assembly and enables
receptor signaling in Schwann cells and
fibroblasts . . . . . . . . . . . . . . 179
A. Wayne Orr and
John M. Sanders and
Melissa Bevard and
Elizabeth Coleman and
Ian J. Sarembock and
Martin Alexander Schwartz The subendothelial extracellular matrix
modulates NF-$ \kappa $B activation by
flow . . . . . . . . . . . . . . . . . . 191
Nathan N. Alder and
Ying Shen and
Jeffrey L. Brodsky and
Linda M. Hendershot and
Arthur E. Johnson Correction . . . . . . . . . . . . . . . 203
Shuji Kotani and
Hirofumi Tanaka and
Hideyo Yasuda and
Kazuo Todokoro Retraction . . . . . . . . . . . . . . . 205
Nicole LeBrasseur Wnt + BMP = stem cell . . . . . . . . . ??
Nicole LeBrasseur Microtubules born on microtubules . . . ??
Nicole LeBrasseur Lattice supports single bilayer . . . . ??
Nicole LeBrasseur One SecY is enough . . . . . . . . . . . ??
Nicole LeBrasseur Selectivity for eIF4E . . . . . . . . . ??
William A. Wells Lipid-driven sorting and fission . . . . ??
William A. Wells Time encoding by ERKs . . . . . . . . . ??
William A. Wells Kept alive by a bacterial pull . . . . . ??
William A. Wells Division as modified migration . . . . . ??
William A. Wells Really outside signaling . . . . . . . . ??
Kendall Powell Excess secretory products fuse with
lysosomes . . . . . . . . . . . . . . . ??
Kendall Powell The first supper . . . . . . . . . . . . ??
Kendall Powell Were mitochondrial contractions driving
the cellular energy cycle? . . . . . . . 217
Kurt S. Cannon and
Eran Or and
William M. Clemons and
Yoko Shibata and
Tom A. Rapoport Disulfide bridge formation between SecY
and a translocating polypeptide
localizes the translocation pore to the
center of SecY . . . . . . . . . . . . . 219
Julien Dumont and
Muriel Umbhauer and
Pascale Rassinier and
André Hanauer and
Marie-Hél\`ene Verlhac p90Rsk is not involved in cytostatic
factor arrest in mouse oocytes . . . . . 227
Christopher A. Sontag and
James T. Staley and
Harold P. Erickson In vitro assembly and GTP hydrolysis by
bacterial tubulins BtubA and BtubB . . . 233
Pipsa Saharinen and
Katja Kerkelä and
Niklas Ekman and
Marie Marron and
Nicholas Brindle and
Gyun Min Lee and
Hellmut Augustin and
Gou Young Koh and
Kari Alitalo Multiple angiopoietin recombinant
proteins activate the Tie1 receptor
tyrosine kinase and promote its
interaction with Tie2 . . . . . . . . . 239
Biljana Culjkovic and
Ivan Topisirovic and
Lucy Skrabanek and
Melisa Ruiz-Gutierrez and
Katherine L. B. Borden eIF4E promotes nuclear export of cyclin
D1 mRNAs via an element in the 3'UTR . . 245
Y'vonne Albert and
Jennifer Whitehead and
Laurie Eldredge and
John Carter and
Xiaoguang Gao and
Warren G. Tourtellotte Transcriptional regulation of myotube
fate specification and intrafusal muscle
fiber morphogenesis . . . . . . . . . . 257
John Heuser Deep-etch EM reveals that the early
poxvirus envelope is a single membrane
bilayer stabilized by a geodetic
``honeycomb'' surface coat . . . . . . . 269
Daniela A. Sahlender and
Rhys C. Roberts and
Susan D. Arden and
Giulietta Spudich and
Marcus J. Taylor and
J. Paul Luzio and
John Kendrick-Jones and
Folma Buss Optineurin links myosin VI to the Golgi
complex and is involved in Golgi
organization and exocytosis . . . . . . 285
Marcel E. Janson and
Thanuja Gangi Setty and
Anne Paoletti and
P. T. Tran Efficient formation of bipolar
microtubule bundles requires
microtubule-bound $ \gamma $-tubulin
complexes . . . . . . . . . . . . . . . 297
Maurice Kléber and
Hye-Youn Lee and
Heiko Wurdak and
Johanna Buchstaller and
Martin M. Riccomagno and
Lars M. Ittner and
Ueli Suter and
Douglas J. Epstein and
Lukas Sommer Neural crest stem cell maintenance by
combinatorial Wnt and BMP signaling . . 309
Hitesh Patel and
Diane L. Barber A developmentally regulated Na--H
exchanger in \bionameDictyostelium
discoideum is necessary for cell
polarity during chemotaxis . . . . . . . 321
Wanli W. Smith and
Darrell D. Norton and
Myriam Gorospe and
Haibing Jiang and
Shino Nemoto and
Nikki J. Holbrook and
Toren Finkel and
John W. Kusiak Phosphorylation of p66Shc and forkhead
proteins mediates A$ \beta $ toxicity 331
Antonella Santuccione and
Vladimir Sytnyk and
Iryna Leshchyns'ka and
Melitta Schachner Prion protein recruits its neuronal
receptor NCAM to lipid rafts to activate
p59$^{\rm fyn}$ and to enhance neurite
outgrowth . . . . . . . . . . . . . . . 341
Masashi Kishi and
Terrance T. Kummer and
Stephen J. Eglen and
Joshua R. Sanes LL5$ \beta $ . . . . . . . . . . . . . . 355
Rabiya S. Tuma Integrins control migration style . . . ??
Rabiya S. Tuma Agrin drives synaptogenesis . . . . . . ??
Rabiya S. Tuma GLUT4 ready to go . . . . . . . . . . . ??
Rabiya S. Tuma Evidence for AMPAR association . . . . . ??
Rabiya S. Tuma Junctions tighten myelin sheaths . . . . ??
Nicole LeBrasseur Autoimmune TCR structure . . . . . . . . ??
Nicole LeBrasseur Quick stop for lymphocytes . . . . . . . ??
Nicole LeBrasseur Separating receptor and ligand . . . . . ??
Nicole LeBrasseur Spines reach out . . . . . . . . . . . . ??
Nicole LeBrasseur Motors take turns . . . . . . . . . . . ??
Laura Bonetta Endothelial tight junctions form the
blood--brain barrier . . . . . . . . . . 378
William A. Wells Defining gap junctions . . . . . . . . . 379
James W. Putney Capacitative calcium entry . . . . . . . 381
Ji-Long Chen and
Raymond V. Fucini and
Lynne Lacomis and
Hediye Erdjument-Bromage and
Paul Tempst and
Mark Stamnes Coatomer-bound Cdc42 regulates dynein
recruitment to COPI vesicles . . . . . . 383
Ayana T. Moore and
Kathleen E. Rankin and
George von Dassow and
Leticia Peris and
Michael Wagenbach and
Yulia Ovechkina and
Annie Andrieux and
Didier Job and
Linda Wordeman MCAK associates with the tips of
polymerizing microtubules . . . . . . . 391
Yuko Fukata and
Anastassios V. Tzingounis and
Jonathan C. Trinidad and
Masaki Fukata and
Alma L. Burlingame and
Roger A. Nicoll and
David S. Bredt Molecular constituents of neuronal AMPA
receptors . . . . . . . . . . . . . . . 399
William Walker and
Zi-Qiang Zhou and
Sara Ota and
Anthony Wynshaw-Boris and
Peter J. Hurlin Mnt--Max to Myc--Max complex switching
regulates cell cycle entry . . . . . . . 405
Christian Faul and
Stefan Hüttelmaier and
Jun Oh and
Virginie Hachet and
Robert H. Singer and
Peter Mundel Promotion of importin $ \alpha
$-mediated nuclear import by the
phosphorylation-dependent binding of
cargo protein to 14-3-3 . . . . . . . . 415
Masaaki Komatsu and
Satoshi Waguri and
Takashi Ueno and
Junichi Iwata and
Shigeo Murata and
Isei Tanida and
Junji Ezaki and
Noboru Mizushima and
Yoshinori Ohsumi and
Yasuo Uchiyama and
Eiki Kominami and
Keiji Tanaka and
Tomoki Chiba Impairment of starvation-induced and
constitutive autophagy in Atg7-deficient
mice . . . . . . . . . . . . . . . . . . 425
Jack Roos and
Paul J. DiGregorio and
Andriy V. Yeromin and
Kari Ohlsen and
Maria Lioudyno and
Shenyuan Zhang and
Olga Safrina and
J. Ashot Kozak and
Steven L. Wagner and
Michael D. Cahalan and
Gönül Veliçelebi and
Kenneth A. Stauderman STIM1, an essential and conserved
component of store-operated Ca$^{2+}$
channel function . . . . . . . . . . . . 435
Hsin-ya Yang and
Paul E. Mains and
Francis J. McNally Kinesin-1 mediates translocation of the
meiotic spindle to the oocyte cortex
through KCA-1, a novel cargo adapter . . 447
Hui Chen and
Daniel M. Cohen and
Dilshad M. Choudhury and
Noriyuki Kioka and
Susan W. Craig Spatial distribution and functional
significance of activated vinculin in
living cells . . . . . . . . . . . . . . 459
Mary M. LaLonde and
Hilde Janssens and
Erica Rosenbaum and
Seok-Yong Choi and
J. Peter Gergen and
Nansi J. Colley and
William S. Stark and
Michael A. Frohman Regulation of phototransduction
responsiveness and retinal degeneration
by a phospholipase D--generated
signaling lipid . . . . . . . . . . . . 471
Vladimir A. Lizunov and
Hideko Matsumoto and
Joshua Zimmerberg and
Samuel W. Cushman and
Vadim A. Frolov Insulin stimulates the halting,
tethering, and fusion of mobile GLUT4
vesicles in rat adipose cells . . . . . 481
Delphine Delacour and
Valérie Gouyer and
Jean-Pierre Zanetta and
Hervé Drobecq and
Emmanuelle Leteurtre and
Georges Grard and
Odile Moreau-Hannedouche and
Emmanuel Maes and
Alexandre Pons and
Sabine André and
André Le Bivic and
Hans Joachim Gabius and
Aki Manninen and
Kai Simons and
Guillemette Huet Galectin-4 and sulfatides in apical
membrane trafficking in enterocyte-like
cells . . . . . . . . . . . . . . . . . 491
Agn\`es O. Martin and
Gérard Alonso and
Nathalie C. Guérineau Agrin mediates a rapid switch from
electrical coupling to chemical
neurotransmission during synaptogenesis 503
Erik H. J. Danen and
Jacco van Rheenen and
Willeke Franken and
Stephan Huveneers and
Petra Sonneveld and
Kees Jalink and
Arnoud Sonnenberg Integrins control motile strategy
through a Rho--cofilin pathway . . . . . 515
Tatsuo Miyamoto and
Kazumasa Morita and
Daisuke Takemoto and
Kosei Takeuchi and
Yuka Kitano and
Tsuyoshi Miyakawa and
Kiyomi Nakayama and
Yasushi Okamura and
Hiroyuki Sasaki and
Yoshiki Miyachi and
Mikio Furuse and
Shoichiro Tsukita Tight junctions in Schwann cells of
peripheral myelinated axons . . . . . . 527
Alberto Marcelo Diaz Añel and
Vivek Malhotra Correction . . . . . . . . . . . . . . . 539
Sarah M. Short and
Alexandrine Derrien and
Radha P. Narsimhan and
Jack Lawler and
Donald E. Ingber and
Bruce R. Zetter Correction . . . . . . . . . . . . . . . 541
Nicole LeBrasseur Deacetylate to differentiate . . . . . . ??
Nicole LeBrasseur ER stress shapes muscle . . . . . . . . ??
Nicole LeBrasseur Cdk5 protects huntingtin . . . . . . . . ??
Nicole LeBrasseur Two VEGFs for big or branchy vessels . . ??
Nicole LeBrasseur Complexes to coordinate calcium . . . . ??
William A. Wells A fat ride . . . . . . . . . . . . . . . ??
William A. Wells Make your own network . . . . . . . . . ??
William A. Wells Walk this (and that) way . . . . . . . . ??
William A. Wells Getting ahead by staying still . . . . . ??
William A. Wells RNA in the machine . . . . . . . . . . . ??
William A. Wells The discovery of tubulin . . . . . . . . 552
Laura Bonetta Microtubules shape the cell . . . . . . ??
Laura Bonetta How to make a lysosome . . . . . . . . . ??
Keiko Nakanishi and
Tatsuhiko Sudo and
Nobuhiro Morishima Endoplasmic reticulum stress signaling
transmitted by ATF6 mediates apoptosis
during muscle development . . . . . . . 555
Dairin Kieran and
Majid Hafezparast and
Stephanie Bohnert and
James R. T. Dick and
Joanne Martin and
Giampietro Schiavo and
Elizabeth M. C. Fisher and
Linda Greensmith A mutation in dynein rescues axonal
transport defects and extends the life
span of ALS mice . . . . . . . . . . . . 561
Clare L. Bennett and
Erwin van Rijn and
Steffen Jung and
Kayo Inaba and
Ralph M. Steinman and
Martien L. Kapsenberg and
Björn E. Clausen Inducible ablation of mouse Langerhans
cells diminishes but fails to abrogate
contact hypersensitivity . . . . . . . . 569
Siming Shen and
Jiadong Li and
Patrizia Casaccia-Bonnefil Histone modifications affect timing of
oligodendrocyte progenitor
differentiation in the developing rat
brain . . . . . . . . . . . . . . . . . 577
Vionnie W. C. Yu and
Gourgen Ambartsoumian and
Lieve Verlinden and
Janet M. Moir and
Josée Prud'homme and
Claude Gauthier and
Peter J. Roughley and
René St-Arnaud FIAT represses ATF4-mediated
transcription to regulate bone mass in
transgenic mice . . . . . . . . . . . . 591
Wensheng Lin and
Heather P. Harding and
David Ron and
Brian Popko Endoplasmic reticulum stress modulates
the response of myelinating
oligodendrocytes to the immune cytokine
interferon-$ \gamma $ . . . . . . . . . 603
Christoph Jüschke and
Andrea Wächter and
Blanche Schwappach and
Matthias Seedorf SEC18 /NSF-independent, protein-sorting
pathway from the yeast cortical ER to
the plasma membrane . . . . . . . . . . 613
Ryan M. Drenan and
Craig A. Doupnik and
Maureen P. Boyle and
Louis J. Muglia and
James E. Huettner and
Maurine E. Linder and
Kendall J. Blumer Palmitoylation regulates plasma
membrane--nuclear shuttling of R7BP, a
novel membrane anchor for the RGS7
family . . . . . . . . . . . . . . . . . 623
Slobodan Beronja and
Patrick Laprise and
Ophelia Papoulas and
Milena Pellikka and
John Sisson and
Ulrich Tepass Essential function of \bionameDrosophila
Sec6 in apical exocytosis of epithelial
photoreceptor cells . . . . . . . . . . 635
Shouqing Luo and
Coralie Vacher and
Janet E. Davies and
David C. Rubinsztein Cdk5 phosphorylation of huntingtin
reduces its cleavage by caspases . . . . 647
Eun-Mi Hur and
Yong-Soo Park and
Yang Hoon Huh and
Seung Hyun Yoo and
Kyung-Chul Woo and
Bo-Hwa Choi and
Kyong-Tai Kim Junctional membrane inositol
1,4,5-trisphosphate receptor complex
coordinates sensitization of the silent
EGF-induced Ca$^{2+}$ signaling . . . . 657
Kerstin Reim and
Heike Wegmeyer and
Johann Helmut Brandstätter and
Mingshan Xue and
Christian Rosenmund and
Thomas Dresbach and
Kay Hofmann and
Nils Brose Structurally and functionally unique
complexins at retinal ribbon synapses 669
Sunyoung Lee and
Shahla M. Jilani and
Ganka V. Nikolova and
Darren Carpizo and
M. Luisa Iruela-Arispe Processing of VEGF--A by matrix
metalloproteinases regulates
bioavailability and vascular patterning
in tumors . . . . . . . . . . . . . . . 681
Rabiya S. Tuma Basal body timing . . . . . . . . . . . ??
Rabiya S. Tuma Interleukins drive the cell cycle . . . ??
Rabiya S. Tuma Regulated yeast death --- in colonies ??
Rabiya S. Tuma Holding on to peroxisomes . . . . . . . ??
Rabiya S. Tuma Sperm's quick calcium response . . . . . ??
Nicole LeBrasseur Does the Kai clock rotate? . . . . . . . ??
Nicole LeBrasseur Stiffening under pressure . . . . . . . ??
Nicole LeBrasseur Myosin reins in neurites . . . . . . . . ??
Nicole LeBrasseur Inequality made equal . . . . . . . . . ??
Nicole LeBrasseur Centromeric links in meiosis . . . . . . ??
Laura Bonetta Tension gets chromosomes oriented . . . ??
Laura Bonetta Not actin, not myosin, but intermediate ??
Laura Bonetta Seeing peroxisomes . . . . . . . . . . . 705
Lynne M. Quarmby and
Jeremy D. K. Parker Cilia and the cell cycle? . . . . . . . 707
Libu\vse Váchová and
Zdena Palková Physiological regulation of yeast cell
death in multicellular colonies is
triggered by ammonia . . . . . . . . . . 711
Hong-Kyung Kim and
Jeong-Gu Kang and
Shigehiko Yumura and
Charles J. Walsh and
Jin Won Cho and
JooHun Lee De novo formation of basal bodies in
Naegleria gruberi . . . . . . . . . . . 719
Christopher D. Wood and
Takuya Nishigaki and
Toshiaki Furuta and
Shoji A. Baba and
Alberto Darszon Real-time analysis of the role of
Ca$^{2+}$ in flagellar movement and
motility in single sea urchin sperm . . 725
Alessandro Brero and
Hariharan P. Easwaran and
Danny Nowak and
Ingrid Grunewald and
Thomas Cremer and
Heinrich Leonhardt and
M. Cristina Cardoso Methyl CpG--binding proteins induce
large-scale chromatin reorganization
during terminal differentiation . . . . 733
Patrice Vitali and
Eugenia Basyuk and
Elodie Le Meur and
Edouard Bertrand and
Françoise Muscatelli and
Jérôme Cavaillé and
Alexander Huttenhofer ADAR2-mediated editing of RNA substrates
in the nucleolus is inhibited by C/D
small nucleolar RNAs . . . . . . . . . . 745
Annette R. Khaled and
Dmitry V. Bulavin and
Christina Kittipatarin and
Wen Qing Li and
Michelle Alvarez and
Kyungjae Kim and
Howard A. Young and
Albert J. Fornace and
Scott K. Durum Cytokine-driven cell cycling is mediated
through Cdc25A . . . . . . . . . . . . . 755
Monica Fagarasanu and
Andrei Fagarasanu and
Yuen Yi C. Tam and
John D. Aitchison and
Richard A. Rachubinski Inp1p is a peroxisomal membrane protein
required for peroxisome inheritance in
\bionameSaccharomyces cerevisiae . . . . 765
Fang Lin and
Diane S. Sepich and
Songhai Chen and
Jacek Topczewski and
Chunyue Yin and
Lilianna Solnica-Krezel and
Heidi Hamm Essential roles of G$ \alpha_{12 / 13} $
signaling in distinct cell behaviors
driving zebrafish convergence and
extension gastrulation movements . . . . 777
Tania Maffucci and
Frank T. Cooke and
Fiona M. Foster and
Colin J. Traer and
Michael J. Fry and
Marco Falasca Class II phosphoinositide $3$-kinase
defines a novel signaling pathway in
cell migration . . . . . . . . . . . . . 789
Meryem Bektas and
Shawn G. Payne and
Hong Liu and
Sravan Goparaju and
Sheldon Milstien and
Sarah Spiegel A novel acylglycerol kinase that
produces lysophosphatidic acid modulates
cross talk with EGFR in prostate cancer
cells . . . . . . . . . . . . . . . . . 801
Shuo Luo and
Yu Chen and
Kwok-On Lai and
Juan Carlos Arévalo and
Stanley C. Froehner and
Marvin E. Adams and
Moses V. Chao and
Nancy Y. Ip $ \alpha $-Syntrophin regulates ARMS
localization at the neuromuscular
junction and enhances EphA4 signaling in
an ARMS-dependent manner . . . . . . . . 813
Nicole LeBrasseur ER domains . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Sorting the mRNA overflow . . . . . . . ??
Nicole LeBrasseur Cycles of muscle fusion . . . . . . . . ??
Nicole LeBrasseur Links that separate . . . . . . . . . . ??
Nicole LeBrasseur Tumors feed on collagen . . . . . . . . ??
Kara A. Nyberg Breaking down symmetry . . . . . . . . . ??
Kara A. Nyberg Weaker is better . . . . . . . . . . . . ??
Kara A. Nyberg Putting the pinch on cell division . . . ??
Kara A. Nyberg The death stops here . . . . . . . . . . ??
Kara A. Nyberg Making mature attachments . . . . . . . ??
Laura Bonetta Actin in locomotion . . . . . . . . . . 838
Laura Bonetta Actin in nonmuscle cells . . . . . . . . ??
Laura Bonetta Growth cones make proteins, too . . . . ??
Robert V. Skibbens Unzipped and loaded . . . . . . . . . . 841
Rudy L. Juliano and
Vidula R. Dixit and
Hyunmin Kang and
Tai Young Kim and
Yuko Miyamoto and
Dong Xu Epigenetic manipulation of gene
expression . . . . . . . . . . . . . . . 847
Thomas J. Maresca and
Benjamin S. Freedman and
Rebecca Heald Histone H1 is essential for mitotic
chromosome architecture and segregation
in \bionameXenopus laevis egg extracts 859
Nancy Kedersha and
Georg Stoecklin and
Maranatha Ayodele and
Patrick Yacono and
Jens Lykke-Andersen and
Marvin J. Fritzler and
Donalyn Scheuner and
Randal J. Kaufman and
David E. Golan and
Paul Anderson Stress granules and processing bodies
are dynamically linked sites of mRNP
remodeling . . . . . . . . . . . . . . . 871
Tomoshige Kino and
Anatoly Tiulpakov and
Takamasa Ichijo and
Ly Chheng and
Tohru Kozasa and
George P. Chrousos G protein $ \beta $ interacts with the
glucocorticoid receptor and suppresses
its transcriptional activity in the
nucleus . . . . . . . . . . . . . . . . 885
Cosima Luedeke and
Stéphanie Buvelot Frei and
Ivo Sbalzarini and
Heinz Schwarz and
Anne Spang and
Yves Barral Septin-dependent compartmentalization of
the endoplasmic reticulum during yeast
polarized growth . . . . . . . . . . . . 897
Sree Devi Menon and
Zalina Osman and
Kho Chenchill and
William Chia A positive feedback loop between
Dumbfounded and Rolling pebbles leads to
myotube enlargement in
\bionameDrosophila . . . . . . . . . . . 909
Keiichi Hishikawa and
Takeshi Marumo and
Shigeki Miura and
Asato Nakanishi and
Yumi Matsuzaki and
Katsunori Shibata and
Tomoko Ichiyanagi and
Hiroko Kohike and
Takuya Komori and
Ichiro Takahashi and
Osamu Takase and
Naohiko Imai and
Masahiro Yoshikawa and
Toshihiko Inowa and
Matsuhiko Hayashi and
Toshio Nakaki and
Hiromitsu Nakauchi and
Hideyuki Okano and
Toshiro Fujita Musculin\slash MyoR is expressed in
kidney side population cells and can
regulate their function . . . . . . . . 921
Torsten Wittmann and
Clare M. Waterman-Storer Spatial regulation of CLASP affinity for
microtubules by Rac1 and GSK3$ \beta $
in migrating epithelial cells . . . . . 929
Tang-Long Shen and
Ann Y.-J. Park and
Ana Alcaraz and
Xu Peng and
Ihnkyung Jang and
Pandelakis Koni and
Richard A. Flavell and
Hua Gu and
Jun-Lin Guan Conditional knockout of focal adhesion
kinase in endothelial cells reveals its
role in angiogenesis and vascular
development in late embryogenesis . . . 941
Bernhard Sommer and
Adrian Oprins and
Catherine Rabouille and
Sean Munro The exocyst component Sec5 is present on
endocytic vesicles in the oocyte of
\bionameDrosophila melanogaster . . . . 953
Samuel T. Hess and
Mukesh Kumar and
Anil Verma and
Jane Farrington and
Anne Kenworthy and
Joshua Zimmerberg Quantitative electron microscopy and
fluorescence spectroscopy of the
membrane distribution of influenza
hemagglutinin . . . . . . . . . . . . . 965
Alejandro C. Curino and
Lars H. Engelholm and
Susan S. Yamada and
Kenn Holmbeck and
Leif R. Lund and
Alfredo A. Molinolo and
Niels Behrendt and
Boye Schnack Nielsen and
Thomas H. Bugge Intracellular collagen degradation
mediated by uPARAP/Endo180 is a major
pathway of extracellular matrix turnover
during malignancy . . . . . . . . . . . 977
Guillaume Bompard and
Emmanuelle Caron Correction . . . . . . . . . . . . . . . 987
Rabiya S. Tuma RhoA controls furrow formation . . . . . ??
Rabiya S. Tuma A new mode of moving . . . . . . . . . . ??
Rabiya S. Tuma Sun and survival with Hif1$ \alpha $ . . ??
Rabiya S. Tuma Regulating the prostate . . . . . . . . ??
Rabiya S. Tuma The degranulation two-step . . . . . . . ??
Nicole LeBrasseur Dividing via miRNA . . . . . . . . . . . ??
Nicole LeBrasseur Infection in trans . . . . . . . . . . . ??
Nicole LeBrasseur Rec'd recombination . . . . . . . . . . ??
Nicole LeBrasseur Patterned by adhesion . . . . . . . . . ??
Nicole LeBrasseur Stability in numbers . . . . . . . . . . ??
Laura Bonetta Spectrin is peripheral . . . . . . . . . ??
Kendall Powell A macrophage mystery leads to dendritic
discovery . . . . . . . . . . . . . . . ??
Fumihiro Higashino and
Mariko Aoyagi and
Akiko Takahashi and
Masaho Ishino and
Masato Taoka and
Toshiaki Isobe and
Masanobu Kobayashi and
Yasunori Totsuka and
Takao Kohgo and
Masanobu Shindoh Adenovirus E4orf6 targets pp32/LANP to
control the fate of ARE-containing mRNAs
by perturbing the CRM1-dependent
mechanism . . . . . . . . . . . . . . . 15
Nicolas Barnich and
Jose E. Aguirre and
Hans-Christian Reinecker and
Ramnik Xavier and
Daniel K. Podolsky Membrane recruitment of NOD2 in
intestinal epithelial cells is essential
for nuclear factor--$ \kappa $B
activation in muramyl dipeptide
recognition . . . . . . . . . . . . . . 21
Edith N. G. Houben and
Raz Zarivach and
Bauke Oudega and
Joen Luirink Early encounters of a nascent membrane
protein . . . . . . . . . . . . . . . . 27
Jeffrey Lynch and
Lei Guo and
Pascal Gelebart and
Kaari Chilibeck and
Jian Xu and
Jeffery D. Molkentin and
Luis B. Agellon and
Marek Michalak Calreticulin signals upstream of
calcineurin and MEF2C in a critical
Ca$^{2+}$-dependent signaling cascade 37
Roser Busc\`a and
Edurne Berra and
Cédric Gaggioli and
Mehdi Khaled and
Karine Bille and
Barbara Marchetti and
Raphaël Thyss and
Giorgos Fitsialos and
Lionel Larrib\`ere and
Corine Bertolotto and
Thierry Virolle and
Pascal Barbry and
Jacques Pouysségur and
Gilles Ponzio and
Robert Ballotti Hypoxia-inducible factor 1$ \alpha $ is
a new target of
microphthalmia-associated transcription
factor (MITF) in melanoma cells . . . . 49
Jae J. Song and
Yong J. Lee Dissociation of Akt1 from its negative
regulator JIP1 is mediated through the
ASK1--MEK--JNK signal transduction
pathway during metabolic oxidative
stress . . . . . . . . . . . . . . . . . 61
Kenji Matsushita and
Craig N. Morrell and
Rebecca J. A. Mason and
Munekazu Yamakuchi and
Firdous A. Khanday and
Kaikobad Irani and
Charles J. Lowenstein Hydrogen peroxide regulation of
endothelial exocytosis by inhibition of
N-ethylmaleimide sensitive factor . . . 73
Sarah N. Salm and
Patricia E. Burger and
Sandra Coetzee and
Ken Goto and
David Moscatelli and
E. Lynette Wilson TGF-$ \beta $ maintains dormancy of
prostatic stem cells in the proximal
region of ducts . . . . . . . . . . . . 81
William M. Bement and
Hél\`ene A. Benink and
George von Dassow A microtubule-dependent zone of active
RhoA during cleavage plane specification 91
Gregory J. Pazour and
Nathan Agrin and
John Leszyk and
George B. Witman Proteomic analysis of a eukaryotic
cilium . . . . . . . . . . . . . . . . . 103
Keigo Nishida and
Satoru Yamasaki and
Yukitaka Ito and
Koki Kabu and
Kotaro Hattori and
Tohru Tezuka and
Hirofumi Nishizumi and
Daisuke Kitamura and
Ryo Goitsuka and
Raif S. Geha and
Tadashi Yamamoto and
Takeshi Yagi and
Toshio Hirano Fc$ \epsilon $RI-mediated mast cell
degranulation requires
calcium-independent
microtubule-dependent translocation of
granules to the plasma membrane . . . . 115
Bart Dermaut and
Koenraad K. Norga and
Artur Kania and
Patrik Verstreken and
Hongling Pan and
Yi Zhou and
Patrick Callaerts and
Hugo J. Bellen Aberrant lysosomal carbohydrate storage
accompanies endocytic defects and
neurodegeneration in \bionameDrosophila
benchwarmer . . . . . . . . . . . . . . 127
Andrew Smith and
Yolanda R. Carrasco and
Paula Stanley and
Nelly Kieffer and
Facundo D. Batista and
Nancy Hogg A talin-dependent LFA-1 focal zone is
formed by rapidly migrating T
lymphocytes . . . . . . . . . . . . . . 141
Rabiya S. Tuma Correction . . . . . . . . . . . . . . . 153
Rabiya S. Tuma Linking pore and pole . . . . . . . . . ??
Rabiya S. Tuma Extra exocytosis rescues polarity . . . ??
Rabiya S. Tuma Adaptor to nucleus . . . . . . . . . . . ??
Rabiya S. Tuma Repair orders . . . . . . . . . . . . . ??
Rabiya S. Tuma Viruses catch a wave . . . . . . . . . . ??
Kara A. Nyberg Selective clusters . . . . . . . . . . . ??
Kara A. Nyberg Axon size matters . . . . . . . . . . . ??
Kara A. Nyberg Sensing voltage for function . . . . . . ??
Kara A. Nyberg Fiber flex . . . . . . . . . . . . . . . ??
Kara A. Nyberg Smell's different . . . . . . . . . . . ??
Kendall Powell Curbside recycling at the synapse . . . 166
Kendall Powell Actin pushes in bizarre places . . . . . 167
Manuela Vecchi and
Pier Paolo Di Fiore It's HIP to be a hub . . . . . . . . . . 169
Shmuel Muallem Decoding Ca$^{2+}$ signals . . . . . . . 173
Joseph Lin and
Mark J. Miller and
Andrey S. Shaw The c--SMAC . . . . . . . . . . . . . . 177
Qing Liu and
Simon A. Walker and
Dingcheng Gao and
James A. Taylor and
Yan-Feng Dai and
Rebecca S. Arkell and
Martin D. Bootman and
H. Llewelyn Roderick and
Peter J. Cullen and
Peter J. Lockyer CAPRI and RASAL impose different modes
of information processing on Ras due to
contrasting temporal filtering of
Ca$^{2+}$ . . . . . . . . . . . . . . . 183
Ian G. Mills and
Luke Gaughan and
Craig Robson and
Theodora Ross and
Stuart McCracken and
John Kelly and
David E. Neal Huntingtin interacting protein 1
modulates the transcriptional activity
of nuclear hormone receptors . . . . . . 191
Simon Bekker-Jensen and
Claudia Lukas and
Fredrik Melander and
Jiri Bartek and
Jiri Lukas Dynamic assembly and sustained retention
of 53BP1 at the sites of DNA damage are
controlled by Mdc1/NFBD1 . . . . . . . . 201
Edgar Trelles-Sticken and
Caroline Adelfalk and
Josef Loidl and
Harry Scherthan Meiotic telomere clustering requires
actin for its formation and cohesin for
its resolution . . . . . . . . . . . . . 213
Mario Niepel and
Caterina Strambio-de-Castillia and
Joseph Fasolo and
Brian T. Chait and
Michael P. Rout The nuclear pore complex--associated
protein, Mlp2p, binds to the yeast
spindle pole body and promotes its
efficient assembly . . . . . . . . . . . 225
Erik E. Griffin and
Johannes Graumann and
David C. Chan The WD40 protein Caf4p is a component of
the mitochondrial fission machinery and
recruits Dnm1p to mitochondria . . . . . 237
Claudio G. Giraudo and
Chuan Hu and
Daoqi You and
Avram M. Slovic and
Eugene V. Mosharov and
David Sulzer and
Thomas J. Melia and
James E. Rothman SNAREs can promote complete fusion and
hemifusion as alternative outcomes . . . 249
J. Shawn Goodwin and
Kimberly R. Drake and
Carl Rogers and
Latasha Wright and
Jennifer Lippincott-Schwartz and
Mark R. Philips and
Anne K. Kenworthy Depalmitoylated Ras traffics to and from
the Golgi complex via a nonvesicular
pathway . . . . . . . . . . . . . . . . 261
Xiaoyu Zhang and
Puyue Wang and
Akanksha Gangar and
Jian Zhang and
Patrick Brennwald and
Daniel TerBush and
Wei Guo Lethal giant larvae proteins interact
with the exocyst complex and are
involved in polarized exocytosis . . . . 273
Margaret D. Myers and
Leonard L. Dragone and
Arthur Weiss Src-like adaptor protein down-regulates
T cell receptor (TCR)--CD3 expression by
targeting TCR$ \zeta $ for degradation 285
Jun Sunayama and
Fuminori Tsuruta and
Norihisa Masuyama and
Yukiko Gotoh JNK antagonizes Akt-mediated survival
signals by phosphorylating 14-3-3 . . . 295
Yingwei Mao and
Angel W.-M. Lee A novel role for Gab2 in bFGF-mediated
cell survival during retinoic
acid--induced neuronal differentiation 305
Maik J. Lehmann and
Nathan M. Sherer and
Carolyn B. Marks and
Marc Pypaert and
Walther Mothes Actin- and myosin-driven movement of
viruses along filopodia precedes their
entry into cells . . . . . . . . . . . . 317
Rabiya S. Tuma One ROCK is not like another . . . . . . ??
Rabiya S. Tuma NAD to the rescue . . . . . . . . . . . ??
Rabiya S. Tuma Ribosome cycling . . . . . . . . . . . . ??
Rabiya S. Tuma Eating Staph . . . . . . . . . . . . . . ??
Rabiya S. Tuma Two-step adhesion . . . . . . . . . . . ??
Nicole LeBrasseur Generous bacteria . . . . . . . . . . . ??
Nicole LeBrasseur MMPs rearrange DNA . . . . . . . . . . . ??
Nicole LeBrasseur Need an EGO to escape arrest . . . . . . ??
Nicole LeBrasseur The evolution of hubs . . . . . . . . . ??
Nicole LeBrasseur DNA damage lures T cells . . . . . . . . ??
Mitch Leslie Lost in translation . . . . . . . . . . 338
Mitch Leslie Powered by gel . . . . . . . . . . . . . ??
Mitch Leslie EGF is internalized and degraded . . . . ??
Jong-Soo Kim and
Tatiana B. Krasieva and
Hitoshi Kurumizaka and
David J. Chen and
A. Malcolm R. Taylor and
Kyoko Yokomori Independent and sequential recruitment
of NHEJ and HR factors to DNA damage
sites in mammalian cells . . . . . . . . 341
Jing Wang and
Qiwei Zhai and
Ying Chen and
Estelle Lin and
Wei Gu and
Michael W. McBurney and
Zhigang He A local mechanism mediates NAD-dependent
protection of axon degeneration . . . . 349
Dawit Kidane and
Peter L. Graumann Dynamic formation of RecA filaments at
DNA double strand break repair centers
in live cells . . . . . . . . . . . . . 357
Michael Hölzel and
Michaela Rohrmoser and
Martin Schlee and
Thomas Grimm and
Thomas Harasim and
Anastassia Malamoussi and
Anita Gruber-Eber and
Elisabeth Kremmer and
Wolfgang Hiddemann and
Georg W. Bornkamm and
Dirk Eick Mammalian WDR12 is a novel member of the
Pes1--Bop1 complex and is required for
ribosome biogenesis and cell
proliferation . . . . . . . . . . . . . 367
Boyi Gan and
Zara K. Melkoumian and
Xiaoyang Wu and
Kun-Liang Guan and
Jun-Lin Guan Identification of FIP200 interaction
with the TSC1--TSC2 complex and its role
in regulation of cell size control . . . 379
Iva Ivanovska and
J. Marie Hardwick Viruses activate a genetically conserved
cell death pathway in a unicellular
organism . . . . . . . . . . . . . . . . 391
Cagri G. Besirli and
Erwin F. Wagner and
Eugene M. Johnson The limited role of NH$_2$-terminal
c--Jun phosphorylation in neuronal
apoptosis . . . . . . . . . . . . . . . 401
Ichiro Nakano and
Andres A. Paucar and
Ruchi Bajpai and
Joseph D. Dougherty and
Amani Zewail and
Theresa K. Kelly and
Kevin J. Kim and
Jing Ou and
Matthias Groszer and
Tetsuya Imura and
William A. Freije and
Stanley F. Nelson and
Michael V. Sofroniew and
Hong Wu and
Xin Liu and
Alexey V. Terskikh and
Daniel H. Geschwind and
Harley I. Kornblum Maternal embryonic leucine zipper kinase
(MELK) regulates multipotent neural
progenitor proliferation . . . . . . . . 413
Marc Fivaz and
Tobias Meyer Reversible intracellular translocation
of KRas but not HRas in hippocampal
neurons regulated by Ca$^{2+}$
/calmodulin . . . . . . . . . . . . . . 429
Atsuko Yoneda and
Hinke A. B. Multhaupt and
John R. Couchman The Rho kinases I and II regulate
different aspects of myosin II activity 443
Ji Luo and
Seth J. Field and
Jennifer Y. Lee and
Jeffrey A. Engelman and
Lewis C. Cantley The p85 regulatory subunit of
phosphoinositide $3$-kinase
down-regulates IRS-1 signaling via the
formation of a sequestration complex . . 455
Tina M. Leisner and
Mingjuan Liu and
Zahara M. Jaffer and
Jonathan Chernoff and
Leslie V. Parise Essential role of CIB1 in regulating
PAK1 activation and cell migration . . . 465
Lynda M. Stuart and
Jiusheng Deng and
Jessica M. Silver and
Kazue Takahashi and
Anita A. Tseng and
Elizabeth J. Hennessy and
R. Alan B. Ezekowitz and
Kathryn J. Moore Response to Staphylococcus aureus
requires CD36-mediated phagocytosis
triggered by the COOH-terminal
cytoplasmic domain . . . . . . . . . . . 477
Céline Leyvraz and
Roch-Philippe Charles and
Isabelle Rubera and
Marjorie Guitard and
Samuel Rotman and
Bernadette Breiden and
Konrad Sandhoff and
Edith Hummler The epidermal barrier function is
dependent on the serine protease CAP1/
Prss8 . . . . . . . . . . . . . . . . . 487
Erik H. J. Danen and
Jacco van Rheenen and
Willeke Franken and
Stephan Huveneers and
Petra Sonneveld and
Kees Jalink and
Arnoud Sonnenberg Correction . . . . . . . . . . . . . . . 497
Nicole LeBrasseur Nonadhesion-based sorting . . . . . . . ??
Nicole LeBrasseur Replication complexes in neuronal
morphology . . . . . . . . . . . . . . . ??
Nicole LeBrasseur A hairy kinase . . . . . . . . . . . . . ??
Nicole LeBrasseur Exocyst finds way without Rho . . . . . ??
Nicole LeBrasseur Building glial microtubules . . . . . . ??
Rabiya S. Tuma Retrograde tRNAs . . . . . . . . . . . . ??
Rabiya S. Tuma Linking centrosomes and actin . . . . . ??
Rabiya S. Tuma Making ROS for apoptosis . . . . . . . . ??
Rabiya S. Tuma Dynein holds still . . . . . . . . . . . ??
Rabiya S. Tuma Cohesins and breaks in yeast . . . . . . ??
Kendall Powell The sticky business of discovering
cadherins . . . . . . . . . . . . . . . 514
Kendall Powell Contacting the matrix . . . . . . . . . ??
Kendall Powell Myosin powers cytokinesis . . . . . . . ??
Michael D. Ehlers Dendrite development . . . . . . . . . . 517
Otilia V. Vieira and
Paul Verkade and
Aki Manninen and
Kai Simons FAPP2 is involved in the transport of
apical cargo in polarized MDCK cells . . 521
Zhen Huang and
Keling Zang and
Louis F. Reichardt The origin recognition core complex
regulates dendrite and spine development
in postmitotic neurons . . . . . . . . . 527
Ilke M. Krouwels and
Karien Wiesmeijer and
Tsion E. Abraham and
Chris Molenaar and
Nico P. Verwoerd and
Hans J. Tanke and
Roeland W. Dirks A glue for heterochromatin maintenance 537
Flávio H. Beraldo and
Fabiana M. Almeida and
Aline M. da Silva and
Célia R. S. Garcia Cyclic AMP and calcium interplay as
second messengers in melatonin-dependent
regulation of Plasmodium falciparum cell
cycle . . . . . . . . . . . . . . . . . 551
Laura Alonso and
Hitoshi Okada and
Hilda Amalia Pasolli and
Andrew Wakeham and
Annick Itie You-Ten and
Tak W. Mak and
Elaine Fuchs Sgk3 links growth factor signaling to
maintenance of progenitor cells in the
hair follicle . . . . . . . . . . . . . 559
Özlem Yüce and
Alisa Piekny and
Michael Glotzer An ECT2--centralspindlin complex
regulates the localization and function
of RhoA . . . . . . . . . . . . . . . . 571
Olivier Roumanie and
Hao Wu and
Jeffrey N. Molk and
Guendalina Rossi and
Kerry Bloom and
Patrick Brennwald Rho GTPase regulation of exocytosis in
yeast is independent of GTP hydrolysis
and polarization of the exocyst complex 583
Eric Anderson and
Sandra Maday and
Jeff Sfakianos and
Michael Hull and
Bettina Winckler and
David Sheff and
Heike Fölsch and
Ira Mellman Transcytosis of NgCAM in epithelial
cells reflects differential signal
recognition on the endocytic and
secretory pathways . . . . . . . . . . . 595
Hye-Won Shin and
Mitsuko Hayashi and
Savvas Christoforidis and
Sandra Lacas-Gervais and
Sebastian Hoepfner and
Markus R. Wenk and
Jan Modregger and
Sandrine Uttenweiler-Joseph and
Matthias Wilm and
Arne Nystuen and
Wayne N. Frankel and
Michele Solimena and
Pietro De Camilli and
Marino Zerial An enzymatic cascade of Rab5 effectors
regulates phosphoinositide turnover in
the endocytic pathway . . . . . . . . . 607
Diane S. Lidke and
Keith A. Lidke and
Bernd Rieger and
Thomas M. Jovin and
Donna J. Arndt-Jovin Reaching out for signals . . . . . . . . 619
Winnie W. Y. Lui-Roberts and
Lucy M. Collinson and
Lindsay J. Hewlett and
Grégoire Michaux and
Daniel F. Cutler An AP-1/clathrin coat plays a novel and
essential role in forming the
Weibel--Palade bodies of endothelial
cells . . . . . . . . . . . . . . . . . 627
Vladimir Sirotkin and
Christopher C. Beltzner and
Jean-Baptiste Marchand and
Thomas D. Pollard Interactions of WASp, myosin--I, and
verprolin with Arp2/3 complex during
actin patch assembly in fission yeast 637
William Dentler Intraflagellar transport (IFT) during
assembly and disassembly of
Chlamydomonas flagella . . . . . . . . . 649
John Lee and
Michel Gravel and
Rulin Zhang and
Pierre Thibault and
Peter E. Braun Process outgrowth in oligodendrocytes is
mediated by CNP, a novel microtubule
assembly myelin protein . . . . . . . . 661
Wolfgang E. Reintsch and
Anette Habring-Mueller and
Renee W. Wang and
Anne Schohl and
François Fagotto $ \beta $-Catenin controls cell sorting
at the notochord--somite boundary
independently of cadherin-mediated
adhesion . . . . . . . . . . . . . . . . 675
Rabiya S. Tuma Hiding proteins in the nucleolus . . . . ??
Rabiya S. Tuma Immortal DNA . . . . . . . . . . . . . . ??
Rabiya S. Tuma A little Rac goes a long way . . . . . . ??
Rabiya S. Tuma Controlling cadherin . . . . . . . . . . ??
Rabiya S. Tuma Sticky interactions . . . . . . . . . . ??
Nicole LeBrasseur A view of primitive organelles . . . . . ??
Nicole LeBrasseur The early neurite gets the axon . . . . ??
Nicole LeBrasseur APP for injury repair . . . . . . . . . ??
Nicole LeBrasseur A new mRNA polymerase . . . . . . . . . ??
Nicole LeBrasseur Local power for synapses . . . . . . . . ??
Kendall Powell Microtubules as a gyroscope for cells on
the go . . . . . . . . . . . . . . . . . 700
Kendall Powell Basal lamina instructs innervation . . . ??
Kendall Powell Actin and microtubules interact via MAPs ??
Claudia Wellbrock and
Richard Marais Elevated expression of MITF counteracts
B--RAF--stimulated melanocyte and
melanoma cell proliferation . . . . . . 703
Oi Kwan Wong and
Guowei Fang Plx1 is the 3F3/2 kinase responsible for
targeting spindle checkpoint proteins to
kinetochores . . . . . . . . . . . . . . 709
Phillip Karpowicz and
Cindi Morshead and
Angela Kam and
Eric Jervis and
John Ramunas and
Vincent Cheng and
Derek van der Kooy Support for the immortal strand
hypothesis: neural stem cells partition
DNA asymmetrically in vitro . . . . . . 721
Karim Mekhail and
Mireille Khacho and
Amanda Carrigan and
Robert R. J. Hache and
Lakshman Gunaratnam and
Stephen Lee Regulation of ubiquitin ligase dynamics
by the nucleolus . . . . . . . . . . . . 733
Parker L. Andersen and
Honglin Zhou and
Landon Pastushok and
Trevor Moraes and
Sean McKenna and
Barry Ziola and
Michael J. Ellison and
Vishva M. Dixit and
Wei Xiao Distinct regulation of Ubc13 functions
by the two ubiquitin-conjugating enzyme
variants Mms2 and Uev1A . . . . . . . . 745
Misoon Park and
Daeseok Lee and
Gil-Je Lee and
Inhwan Hwang AtRMR1 functions as a cargo receptor for
protein trafficking to the protein
storage vacuole . . . . . . . . . . . . 757
Akiko Tagawa and
Anna Mezzacasa and
Arnold Hayer and
Andrea Longatti and
Lucas Pelkmans and
Ari Helenius Assembly and trafficking of caveolar
domains in the cell . . . . . . . . . . 769
Jan Lammerding and
Janet Hsiao and
P. Christian Schulze and
Serguei Kozlov and
Colin L. Stewart and
Richard T. Lee Abnormal nuclear shape and impaired
mechanotransduction in emerin-deficient
cells . . . . . . . . . . . . . . . . . 781
Roumen Pankov and
Yukinori Endo and
Sharona Even-Ram and
Masaru Araki and
Katherine Clark and
Edna Cukierman and
Kazue Matsumoto and
Kenneth M. Yamada A Rac switch regulates random versus
directionally persistent cell migration 793
Anne Pacquelet and
Pernille Ròrth Regulatory mechanisms required for
DE-cadherin function in cell migration
and other types of adhesion . . . . . . 803
Tony J. C. Harris and
Mark Peifer The positioning and segregation of
apical cues during epithelial polarity
establishment in \bionameDrosophila . . 813
Petra Muenzner and
Manfred Rohde and
Susanne Kneitz and
Christof R. Hauck CEACAM engagement by human pathogens
enhances cell adhesion and counteracts
bacteria-induced detachment of
epithelial cells . . . . . . . . . . . . 825
Elena Garcia Arias-Salgado and
Fawaz Haj and
Christophe Dubois and
Barry Moran and
Ana Kasirer-Friede and
Barbara C. Furie and
Bruce Furie and
Benjamin G. Neel and
Sanford J. Shattil PTP-1B is an essential positive
regulator of platelet integrin signaling 837
Nicole LeBrasseur LIS-less neurons fall behind . . . . . . ??
Nicole LeBrasseur Formin steps and slips . . . . . . . . . ??
Nicole LeBrasseur eIF2 activated in spots . . . . . . . . ??
Nicole LeBrasseur A Notch outlier . . . . . . . . . . . . ??
Nicole LeBrasseur An actin ruler . . . . . . . . . . . . . ??
William A. Wells Keeping RNA away from DNA . . . . . . . ??
William A. Wells An optical brain . . . . . . . . . . . . ??
William A. Wells Freedom not aggregation . . . . . . . . ??
William A. Wells Turning on by turning . . . . . . . . . ??
William A. Wells Getting nuclei moving . . . . . . . . . ??
Kendall Powell ``Porterplasm'' and the microtrabecular
lattice . . . . . . . . . . . . . . . . 864
Mitch Leslie The isolation of the nuclear lamina . . 865
Mary E. Hatten LIS-less neurons don't even make it to
the starting gate . . . . . . . . . . . 867
Yinghui Mao and
Arshad Desai and
Don W. Cleveland Microtubule capture by CENP--E silences
BubR1-dependent mitotic checkpoint
signaling . . . . . . . . . . . . . . . 873
Stephan Meier and
Walter Neupert and
Johannes M. Herrmann Proline residues of transmembrane
domains determine the sorting of inner
membrane proteins in mitochondria . . . 881
Tom Shemesh and
Takanori Otomo and
Michael K. Rosen and
Alexander D. Bershadsky and
Michael M. Kozlov A novel mechanism of actin filament
processive capping by formin . . . . . . 889
Sandrine Etienne-Manneville and
Jean-Baptiste Manneville and
Sarah Nicholls and
Michael A. Ferenczi and
Alan Hall Cdc42 and Par6-PKC$ \zeta $ regulate the
spatially localized association of Dlg1
and APC to control cell polarization . . 895
Philippe R. J. Bois and
Kamel Izeradjene and
Peter J. Houghton and
John L. Cleveland and
Janet A. Houghton and
Gerard C. Grosveld FOXO1a acts as a selective tumor
suppressor in alveolar rhabdomyosarcoma 903
Maria A. Ferraiuolo and
Sanjukta Basak and
Josee Dostie and
Elizabeth L. Murray and
Daniel R. Schoenberg and
Nahum Sonenberg A role for the eIF4E-binding protein
4E--T in P-body formation and mRNA decay 913
Susan G. Campbell and
Nathaniel P. Hoyle and
Mark P. Ashe Dynamic cycling of eIF2 through a large
eIF2B-containing cytoplasmic body . . . 925
Jin-Wu Tsai and
Yu Chen and
Arnold R. Kriegstein and
Richard B. Vallee LIS1 RNA interference blocks neural stem
cell division, morphogenesis, and
motility at multiple stages . . . . . . 935
Abigail S. McElhinny and
Catherine Schwach and
Melinda Valichnac and
Sarah Mount-Patrick and
Carol C. Gregorio Nebulin regulates the assembly and
lengths of the thin filaments in
striated muscle . . . . . . . . . . . . 947
Qian Cai and
Claudia Gerwin and
Zu-Hang Sheng Syntabulin-mediated anterograde
transport of mitochondria along neuronal
processes . . . . . . . . . . . . . . . 959
Patricia Szajner and
Andrea S. Weisberg and
Jacob Lebowitz and
John Heuser and
Bernard Moss External scaffold of spherical immature
poxvirus particles is made of protein
trimers, forming a honeycomb lattice . . 971
Ena Ladi and
James T. Nichols and
Weihong Ge and
Alison Miyamoto and
Christine Yao and
Liang-Tung Yang and
Jim Boulter and
Yi E. Sun and
Chris Kintner and
Gerry Weinmaster The divergent DSL ligand Dll3 does not
activate Notch signaling but cell
autonomously attenuates signaling
induced by other DSL ligands . . . . . . 983
Ilaria Cascone and
Lucia Napione and
Fabrizio Maniero and
Guido Serini and
Federico Bussolino Stable interaction between $ \alpha $5$
\beta $1 integrin and Tie2 tyrosine
kinase receptor regulates endothelial
cell response to Ang-1 . . . . . . . . . 993
Rabiya S. Tuma Just-right spirals . . . . . . . . . . . ??
Rabiya S. Tuma Fission and disease . . . . . . . . . . ??
Rabiya S. Tuma Calcium, direct from the source . . . . ??
Rabiya S. Tuma Signaling memory from cell shape . . . . ??
Rabiya S. Tuma Stabilizing the minus ends? . . . . . . ??
Kara A. Nyberg New bend on budding . . . . . . . . . . ??
Kara A. Nyberg Gradient upon gradient . . . . . . . . . ??
Kara A. Nyberg Totally tubular chitin . . . . . . . . . ??
Kara A. Nyberg Turning off flow . . . . . . . . . . . . ??
Kara A. Nyberg Tilted tubules . . . . . . . . . . . . . ??
Kendall Powell Viruses catch an endocytic ride into the
cell . . . . . . . . . . . . . . . . . . 1018
Kendall Powell What the cytoskeleton really looks like 1019
Elena Ingerman and
Edward M. Perkins and
Michael Marino and
Jason A. Mears and
J. Michael McCaffery and
Jenny E. Hinshaw and
Jodi Nunnari Dnm1 forms spirals that are structurally
tailored to fit mitochondria . . . . . . 1021
Alexander E. E. Mertens and
Tomasz P. Rygiel and
Cristina Olivo and
Rob van der Kammen and
John G. Collard The Rac activator Tiam1 controls tight
junction biogenesis in keratinocytes
through binding to and activation of the
Par polarity complex . . . . . . . . . . 1029
Teresa P. Barros and
Kazuhisa Kinoshita and
Anthony A. Hyman and
Jordan W. Raff Aurora A activates D--TACC--Msps
complexes exclusively at centrosomes to
stabilize centrosomal microtubules . . . 1039
Kazuhisa Kinoshita and
Tim L. Noetzel and
Laurence Pelletier and
Karl Mechtler and
David N. Drechsel and
Anne Schwager and
Mike Lee and
Jordan W. Raff and
Anthony A. Hyman Aurora A phosphorylation of TACC3/maskin
is required for centrosome-dependent
microtubule assembly in mitosis . . . . 1047
Isabel Peset and
Jeanette Seiler and
Teresa Sardon and
Luis A. Bejarano and
Sonja Rybina and
Isabelle Vernos Function and regulation of Maskin, a
TACC family protein, in microtubule
growth during mitosis . . . . . . . . . 1057
Axel Niemann and
Marcel Ruegg and
Veronica La Padula and
Angelo Schenone and
Ueli Suter Ganglioside-induced differentiation
associated protein 1 is a regulator of
the mitochondrial network . . . . . . . 1067
Muniswamy Madesh and
Brian J. Hawkins and
Tatyana Milovanova and
Cunnigaiper D. Bhanumathy and
Suresh K. Joseph and
Satish P. RamachandraRao and
Kumar Sharma and
Tomohiro Kurosaki and
Aron B. Fisher Selective role for superoxide in
InsP$_3$ receptor-mediated mitochondrial
dysfunction and endothelial apoptosis 1079
Jessica E. Smotrys and
Marissa J. Schoenfish and
Monica A. Stutz and
Maurine E. Linder The vacuolar DHHC--CRD protein Pfa3p is
a protein acyltransferase for Vac8p . . 1091
Sovan Sarkar and
R. Andres Floto and
Zdenek Berger and
Sara Imarisio and
Axelle Cordenier and
Matthieu Pasco and
Lynnette J. Cook and
David C. Rubinsztein Lithium induces autophagy by inhibiting
inositol monophosphatase . . . . . . . . 1101
Takeshi Baba and
Toshiaki Sakisaka and
Sumiko Mochida and
Yoshimi Takai PKA-catalyzed phosphorylation of tomosyn
and its implication in
Ca$^{2+}$-dependent exocytosis of
neurotransmitter . . . . . . . . . . . . 1113
Olav Olsen and
Kimberly A. Moore and
Masaki Fukata and
Toshinari Kazuta and
Jonathan C. Trinidad and
Fred W. Kauer and
Michel Streuli and
Hidemi Misawa and
Alma L. Burlingame and
Roger A. Nicoll and
David S. Bredt Neurotransmitter release regulated by a
MALS-liprin-$ \alpha $ presynaptic
complex . . . . . . . . . . . . . . . . 1127
Yuichi Tomita and
Keisuke Matsumura and
Yoshio Wakamatsu and
Yumi Matsuzaki and
Isao Shibuya and
Haruko Kawaguchi and
Masaki Ieda and
Sachiko Kanakubo and
Takuya Shimazaki and
Satoshi Ogawa and
Noriko Osumi and
Hideyuki Okano and
Keiichi Fukuda Cardiac neural crest cells contribute to
the dormant multipotent stem cell in the
mammalian heart . . . . . . . . . . . . 1135
Madeleine L. Craske and
Marc Fivaz and
Nizar N. Batada and
Tobias Meyer Spines and neurite branches function as
geometric attractors that enhance
protein kinase C action . . . . . . . . 1147
Noriko Ooashi and
Akira Futatsugi and
Fumie Yoshihara and
Katsuhiko Mikoshiba and
Hiroyuki Kamiguchi Cell adhesion molecules regulate
Ca$^{2+}$-mediated steering of growth
cones via cyclic AMP and ryanodine
receptor type 3 . . . . . . . . . . . . 1159
Phillip Karpowicz and
Cindi Morshead and
Angela Kam and
Eric Jervis and
John Ramunas and
Vincent Cheng and
Derek van der Kooy Correction . . . . . . . . . . . . . . . 1169
Christopher D. Wood and
Takuya Nishigaki and
Toshiaki Furuta and
Shoji A. Baba and
Alberto Darszon Correction . . . . . . . . . . . . . . . 1171
Nicole LeBrasseur Contrasts in neuronal aggregates . . . . ??
Nicole LeBrasseur Breaking cell bonds . . . . . . . . . . ??
Nicole LeBrasseur New route to A$ \beta $ . . . . . . . . ??
Nicole LeBrasseur ER for tiny calcium domains . . . . . . ??
Nicole LeBrasseur Docked to prevent secretion . . . . . . ??
William A. Wells Highly goes slowly . . . . . . . . . . . ??
William A. Wells Fate trafficking . . . . . . . . . . . . ??
William A. Wells Antiviral walls . . . . . . . . . . . . ??
William A. Wells Repairing for death . . . . . . . . . . ??
William A. Wells Mito immunity . . . . . . . . . . . . . ??
Kendall Powell Microtubules park parallel in the
half-spindle . . . . . . . . . . . . . . 12
Mitch Leslie Isolating SRP . . . . . . . . . . . . . 13
Noboru Mizushima A$ \beta $ generation in autophagic
vacuoles . . . . . . . . . . . . . . . . 15
Shingo Kose and
Maiko Furuta and
Makiko Koike and
Yoshihiro Yoneda and
Naoko Imamoto The 70-kD heat shock cognate protein
(hsc70) facilitates the nuclear export
of the import receptors . . . . . . . . 19
Susanne Bahe and
York-Dieter Stierhof and
Christopher J. Wilkinson and
Florian Leiss and
Erich A. Nigg Rootletin forms centriole-associated
filaments and functions in centrosome
cohesion . . . . . . . . . . . . . . . . 27
Arne Lindqvist and
Helena Källström and
Andreas Lundgren and
Emad Barsoum and
Christina Karlsson Rosenthal Cdc25B cooperates with Cdc25A to induce
mitosis but has a unique role in
activating cyclin B1--Cdk1 at the
centrosome . . . . . . . . . . . . . . . 35
Huw Parry and
Alex McDougall and
Michael Whitaker Microdomains bounded by endoplasmic
reticulum segregate cell cycle calcium
transients in syncytial
\bionameDrosophila embryos . . . . . . . 47
Tracie DeVries-Seimon and
Yankun Li and
Pin Mei Yao and
Elizabeth Stone and
Yibin Wang and
Roger J. Davis and
Richard Flavell and
Ira Tabas Cholesterol-induced macrophage apoptosis
requires ER stress pathways and
engagement of the type A scavenger
receptor . . . . . . . . . . . . . . . . 61
Gen Matsumoto and
Aleksandar Stojanovic and
Carina I. Holmberg and
Soojin Kim and
Richard I. Morimoto Structural properties and neuronal
toxicity of amyotrophic lateral
sclerosis-associated Cu/Zn superoxide
dismutase 1 aggregates . . . . . . . . . 75
W. Haung Yu and
Ana Maria Cuervo and
Asok Kumar and
Corrinne M. Peterhoff and
Stephen D. Schmidt and
Ju-Hyun Lee and
Panaiyur S. Mohan and
Marc Mercken and
Mark R. Farmery and
Lars O. Tjernberg and
Ying Jiang and
Karen Duff and
Yasuo Uchiyama and
Jan Näslund and
Paul M. Mathews and
Anne M. Cataldo and
Ralph A. Nixon Macroautophagy --- a novel $ \beta
$-amyloid peptide-generating pathway
activated in Alzheimer's disease . . . . 87
Hiroshi Gomi and
Shin Mizutani and
Kazuo Kasai and
Shigeyoshi Itohara and
Tetsuro Izumi Granuphilin molecularly docks insulin
granules to the fusion machinery . . . . 99
Maofu Liao and
Margaret Kielian Domain III from class II fusion proteins
functions as a dominant-negative
inhibitor of virus membrane fusion . . . 111
Katharina Gaus and
Elena Chklovskaia and
Barbara Fazekas de St.Groth and
Wendy Jessup and
Thomas Harder Condensation of the plasma membrane at
the site of T lymphocyte activation . . 121
Fanny S. Chang and
Gil-Soo Han and
George M. Carman and
Kendall J. Blumer A WASp-binding type II
phosphatidylinositol $4$-kinase required
for actin polymerization-driven endosome
motility . . . . . . . . . . . . . . . . 133
Irit Chorna-Ornan and
Vered Tzarfaty and
Galit Ankri-Eliahoo and
Tamar Joel-Almagor and
Nina E. Meyer and
Armin Huber and
François Payre and
Baruch Minke Light-regulated interaction of Dmoesin
with TRP and TRPL channels is required
for maintenance of photoreceptors . . . 143
Johan de Rooij and
Andre Kerstens and
Gaudenz Danuser and
Martin A. Schwartz and
Clare M. Waterman-Storer Integrin-dependent actomyosin
contraction regulates epithelial cell
scattering . . . . . . . . . . . . . . . 153
Tsutomu Fujito and
Wataru Ikeda and
Shigeki Kakunaga and
Yukiko Minami and
Mihoko Kajita and
Yasuhisa Sakamoto and
Morito Monden and
Yoshimi Takai Inhibition of cell movement and
proliferation by cell--cell
contact-induced interaction of Necl-5
with nectin-3 . . . . . . . . . . . . . 165
Maria A. Ferraiuolo and
Sanjukta Basak and
Josee Dostie and
Elizabeth L. Murray and
Daniel R. Schoenberg and
Nahum Sonenberg Correction . . . . . . . . . . . . . . . 175
Keigo Nishida and
Satoru Yamasaki and
Yukitaka Ito and
Koki Kabu and
Kotaro Hattori and
Tohru Tezuka and
Hirofumi Nishizumi and
Daisuke Kitamura and
Ryo Goitsuka and
Raif S. Geha and
Tadashi Yamamoto and
Takeshi Yagi and
Toshio Hirano Correction . . . . . . . . . . . . . . . 177
Rabiya S. Tuma A reversal of Tat . . . . . . . . . . . ??
Rabiya S. Tuma A novel export pathway . . . . . . . . . ??
Rabiya S. Tuma Asymmetry in cytokinesis . . . . . . . . ??
Rabiya S. Tuma Stretching and twisting . . . . . . . . ??
Rabiya S. Tuma Kinesin at both ends . . . . . . . . . . ??
Nicole LeBrasseur Secretion for cytokinesis . . . . . . . ??
Nicole LeBrasseur Polymerase with a protein template . . . ??
Nicole LeBrasseur Wnt for adhesion . . . . . . . . . . . . ??
Nicole LeBrasseur Presenting lipid antigens . . . . . . . ??
Nicole LeBrasseur Marks of death on nuclei . . . . . . . . ??
Mitch Leslie Roll-your-own endothelial tubes . . . . ??
Mitch Leslie A portrait of the nuclear pore complex ??
Mitch Leslie Tagging an organelle . . . . . . . . . . 195
Kevin T. Vaughan TIP maker and TIP marker; EB1 as a
master controller of microtubule plus
ends . . . . . . . . . . . . . . . . . . 197
Xufeng S. Wu and
Grace L. Tsan and
John A. Hammer Melanophilin and myosin Va track the
microtubule plus end on EB1 . . . . . . 201
Masaaki Yoshigi and
Laura M. Hoffman and
Christopher C. Jensen and
H. Joseph Yost and
Mary C. Beckerle Mechanical force mobilizes zyxin from
focal adhesions to actin filaments and
regulates cytoskeletal reinforcement . . 209
Hong Yan and
Jill McCane and
Thomas Toczylowski and
Chinyi Chen Analysis of the \bionameXenopus Werner
syndrome protein in DNA double-strand
break repair . . . . . . . . . . . . . . 217
Gohta Goshima and
François Nédélec and
Ronald D. Vale Mechanisms for focusing mitotic spindle
poles by minus end-directed motor
proteins . . . . . . . . . . . . . . . . 229
Anna V. Kateneva and
Anton A. Konovchenko and
Vincent Guacci and
Michael E. Dresser Recombination protein Tid1p controls
resolution of cohesin-dependent linkages
in meiosis in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 241
Leon Freudzon and
Rachael P. Norris and
Arthur R. Hand and
Shigeru Tanaka and
Yoshinaga Saeki and
Teresa L. Z. Jones and
Mark M. Rasenick and
Catherine H. Berlot and
Lisa M. Mehlmann and
Laurinda A. Jaffe Regulation of meiotic prophase arrest in
mouse oocytes by GPR3, a constitutive
activator of the G$_s$ G protein . . . . 255
Anjon Audhya and
Francie Hyndman and
Ian X. McLeod and
Amy S. Maddox and
John R. Yates and
Arshad Desai and
Karen Oegema A complex containing the Sm protein
CAR-1 and the RNA helicase CGH-1 is
required for embryonic cytokinesis in
\bionameCaenorhabditis elegans . . . . . 267
Alessandra Di Cola and
Colin Robinson Large-scale translocation reversal
within the thylakoid Tat system in vivo 281
Mary Anne Karren and
Emily M. Coonrod and
Teresa K. Anderson and
Janet M. Shaw The role of Fis1p--Mdv1p interactions in
mitochondrial fission complex assembly 291
Andrea Gerbino and
Warren C. Ruder and
Silvana Curci and
Tullio Pozzan and
Manuela Zaccolo and
Aldebaran M. Hofer Termination of cAMP signals by Ca$^{2+}$
and G$ \alpha_i$ via extracellular
Ca$^{2+}$ sensors . . . . . . . . . . . 303
Tatjana C. Jakobs and
Richard T. Libby and
Yixin Ben and
Simon W. M. John and
Richard H. Masland Retinal ganglion cell degeneration is
topological but not cell type specific
in DBA/2J mice . . . . . . . . . . . . . 313
Kathleen A. Ryan and
Sanjay W. Pimplikar Activation of GSK-3 and phosphorylation
of CRMP2 in transgenic mice expressing
APP intracellular domain . . . . . . . . 327
Guido Pante and
Jane Thompson and
Fabienne Lamballe and
Tomoko Iwata and
Ingvar Ferby and
Francis A. Barr and
Alun M. Davies and
Flavio Maina and
Rüdiger Klein Mitogen-inducible gene 6 is an
endogenous inhibitor of HGF/Met-induced
cell migration and neurite growth . . . 337
Michiru Nishita and
Chinatsu Tomizawa and
Masahiro Yamamoto and
Yuji Horita and
Kazumasa Ohashi and
Kensaku Mizuno Spatial and temporal regulation of
cofilin activity by LIM kinase and
Slingshot is critical for directional
cell migration . . . . . . . . . . . . . 349
Tomoyo Okada and
Miguel Lopez-Lago and
Filippo G. Giancotti Merlin\slash NF-2 mediates contact
inhibition of growth by suppressing
recruitment of Rac to the plasma
membrane . . . . . . . . . . . . . . . . 361
Claudia Seelenmeyer and
Sabine Wegehingel and
Ivo Tews and
Markus Künzler and
Markus Aebi and
Walter Nickel Cell surface counter receptors are
essential components of the
unconventional export machinery of
galectin-1 . . . . . . . . . . . . . . . 373
Caroline Cluzel and
Frédéric Saltel and
Jost Lussi and
Frédérique Paulhe and
Beat A. Imhof and
Bernhard Wehrle-Haller The mechanisms and dynamics of $ \alpha
$ v$ \beta $3 integrin clustering in
living cells . . . . . . . . . . . . . . 383
Torsten Wittmann and
Clare M. Waterman-Storer Correction . . . . . . . . . . . . . . . 393
Nicole LeBrasseur Transformed fusions . . . . . . . . . . ??
Nicole LeBrasseur Matrix of death . . . . . . . . . . . . ??
Nicole LeBrasseur Stuck on a channel . . . . . . . . . . . ??
Nicole LeBrasseur G proteins live in excess . . . . . . . ??
Nicole LeBrasseur Cadherin rules microvilli . . . . . . . ??
William A. Wells ClpX eats randomly . . . . . . . . . . . ??
William A. Wells Divided identities in the niche . . . . ??
William A. Wells From error to tetraploid . . . . . . . . ??
William A. Wells NO link to destruction . . . . . . . . . ??
William A. Wells Is it DNA or protein? . . . . . . . . . ??
Kendall Powell Yeast becomes a cell biologist . . . . . 408
Mitch Leslie More than one way to attach . . . . . . ??
Kendall Powell Dishing up bone formation . . . . . . . ??
K. Kevin Pfister and
Elizabeth M. C. Fisher and
Ian R. Gibbons and
Thomas S. Hays and
Erika L. F. Holzbaur and
J. Richard McIntosh and
Mary E. Porter and
Trina A. Schroer and
Kevin T. Vaughan and
George B. Witman and
Stephen M. King and
Richard B. Vallee Cytoplasmic dynein nomenclature . . . . 411
Derek Toomre Spying on IgE receptor signaling . . . . 415
Doron Rapaport How does the TOM complex mediate
insertion of precursor proteins into the
mitochondrial outer membrane? . . . . . 419
Kentaro Inoue and
Amy J. Baldwin and
Rebecca L. Shipman and
Kyoko Matsui and
Steven M. Theg and
Masaru Ohme-Takagi Complete maturation of the plastid
protein translocation channel requires a
type I signal peptidase . . . . . . . . 425
Tomoya Yamaguchi and
Hidemasa Goto and
Tomoya Yokoyama and
Herman Silljé and
Anja Hanisch and
Andreas Uldschmid and
Yasushi Takai and
Takashi Oguri and
Erich A. Nigg and
Masaki Inagaki Phosphorylation by Cdk1 induces
Plk1-mediated vimentin phosphorylation
during mitosis . . . . . . . . . . . . . 431
Chaozhong Zou and
Jun Li and
Yujie Bai and
William T. Gunning and
David E. Wazer and
Vimla Band and
Qingshen Gao Centrobin . . . . . . . . . . . . . . . 437
Nadine K. Kolas and
Anton Svetlanov and
Michelle L. Lenzi and
Frank P. Macaluso and
Steven M. Lipkin and
R. Michael Liskay and
John Greally and
Winfried Edelmann and
Paula E. Cohen Localization of MMR proteins on meiotic
chromosomes in mice indicates distinct
functions during prophase I . . . . . . 447
Burcu Hasdemir and
Daniel J. Fitzgerald and
Ian A. Prior and
Alexei V. Tepikin and
Robert D. Burgoyne Traffic of Kv4 K$^+$ channels mediated
by KChIP1 is via a novel post--ER
vesicular pathway . . . . . . . . . . . 459
Jeff Ishibashi and
Robert L. Perry and
Atsushi Asakura and
Michael A. Rudnicki MyoD induces myogenic differentiation
through cooperation of its NH$_2$- and
COOH-terminal regions . . . . . . . . . 471
Alessandra Sacco and
Regis Doyonnas and
Mark A. LaBarge and
Mark M. Hammer and
Peggy Kraft and
Helen M. Blau IGF-I increases bone marrow contribution
to adult skeletal muscle and enhances
the fusion of myelomonocytic precursors 483
Dominik M. Duelli and
Stephen Hearn and
Michael P. Myers and
Yuri Lazebnik A primate virus generates transformed
human cells by fusion . . . . . . . . . 493
Naciba Benlimame and
Qiang He and
Su Jie and
Dingzhang Xiao and
Ying Jie Xu and
Martin Loignon and
David D. Schlaepfer and
Moulay A. Alaoui-Jamali FAK signaling is critical for
ErbB-2/ErbB-3 receptor cooperation for
oncogenic transformation and invasion 505
Natalie Elia and
Shahar Frechter and
Yinon Gedi and
Baruch Minke and
Zvi Selinger Excess of G$ \beta_e $ over Gq$ \alpha_e
$ in vivo prevents dark, spontaneous
activity of \bionameDrosophila
photoreceptors . . . . . . . . . . . . . 517
Daniel R. Larson and
Julie A. Gosse and
David A. Holowka and
Barbara A. Baird and
Watt W. Webb Temporally resolved interactions between
antigen-stimulated IgE receptors and Lyn
kinase on living cells . . . . . . . . . 527
Andy Hudmon and
Howard Schulman and
James Kim and
Janet M. Maltez and
Richard W. Tsien and
Geoffrey S. Pitt CaMKII tethers to L-type Ca$^{2+}$
channels, establishing a local and
dedicated integrator of Ca$^{2+}$
signals for facilitation . . . . . . . . 537
Cecilia D'Alterio and
Dao D. D. Tran and
Maggie W. Y. Au Yeung and
Michael S. H. Hwang and
Michelle A. Li and
Claudia J. Arana and
Vikram K. Mulligan and
Mary Kubesh and
Praveer Sharma and
Maretta Chase and
Ulrich Tepass and
Dorothea Godt Drosophila melanogaster Cad99C, the
orthologue of human Usher cadherin
PCDH15, regulates the length of
microvilli . . . . . . . . . . . . . . . 549
Viktor Todorovicç and
Chih-Chiun Chen and
Nissim Hay and
Lester F. Lau The matrix protein CCN1 (CYR61) induces
apoptosis in fibroblasts . . . . . . . . 559
Rabiya S. Tuma There's something about the midline . . ??
Rabiya S. Tuma Counting spores . . . . . . . . . . . . ??
Rabiya S. Tuma Seeing muscle evolution . . . . . . . . ??
Rabiya S. Tuma Clipping coreceptors . . . . . . . . . . ??
Rabiya S. Tuma Nonubiquitous autophagy . . . . . . . . ??
Nicole LeBrasseur A Sisyphean helicase . . . . . . . . . . ??
Nicole LeBrasseur Actin adhesion controls bacterial
movement . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Telomeres avoid checkpoints . . . . . . ??
Nicole LeBrasseur Golgi relies on centrin . . . . . . . . ??
Nicole LeBrasseur Signaling with tortoise and hare . . . . ??
Kendall Powell Pursuing the middleman . . . . . . . . . 584
Kendall Powell Frog egg extracts can do a cell's work 585
Matthias Marti and
Jake Baum and
Melanie Rug and
Leann Tilley and
Alan F. Cowman Signal-mediated export of proteins from
the malaria parasite to the host
erythrocyte . . . . . . . . . . . . . . 587
C. Fiona Cullen and
Amy L. Brittle and
Takashi Ito and
Hiroyuki Ohkura The conserved kinase NHK-1 is essential
for mitotic progression and unifying
acentrosomal meiotic spindles in
\bionameDrosophila melanogaster . . . . 593
Geir Bjòrkòy and
Trond Lamark and
Andreas Brech and
Heidi Outzen and
Maria Perander and
Aud Òvervatn and
Harald Stenmark and
Terje Johansen p62/SQSTM1 forms protein aggregates
degraded by autophagy and has a
protective effect on huntingtin-induced
cell death . . . . . . . . . . . . . . . 603
Zoia Muresan and
Virgil Muresan Coordinated transport of phosphorylated
amyloid-$ \beta $ precursor protein and
c--Jun NH$_2$-terminal
kinase--interacting protein-1 . . . . . 615
Christof Taxis and
Philipp Keller and
Zaharoula Kavagiou and
Lars Juhl Jensen and
Julien Colombelli and
Peer Bork and
Ernst H. K. Stelzer and
Michael Knop Spore number control and breeding in
\bionameSaccharomyces cerevisiae . . . . 627
Sylvian Bauer and
Paul H. Patterson The cell cycle--apoptosis connection
revisited in the adult brain . . . . . . 641
Nisrine El Chami and
Fouziha Ikhlef and
Krisztian Kaszas and
Sadok Yakoub and
Eric Tabone and
Benazir Siddeek and
Stéphanie Cunha and
Claude Beaudoin and
Laurent Morel and
Mohamed Benahmed and
Daniel C. Régnier Androgen-dependent apoptosis in male
germ cells is regulated through the
proto-oncoprotein Cbl . . . . . . . . . 651
Wa Xian and
Kathryn L. Schwertfeger and
Tracy Vargo-Gogola and
Jeffrey M. Rosen Pleiotropic effects of FGFR1 on cell
proliferation, survival, and migration
in a $3$D mammary epithelial cell model 663
Hiroko Sano and
Andrew D. Renault and
Ruth Lehmann Control of lateral migration and germ
cell elimination by the
\bionameDrosophila melanogaster lipid
phosphate phosphatases Wunen and Wunen 2 675
Tao Wang and
Yuchen Jiao and
Craig Montell Dissecting independent channel and
scaffolding roles of the
\bionameDrosophila transient receptor
potential channel . . . . . . . . . . . 685
Valentina Di Biase and
Clara Franzini-Armstrong Evolution of skeletal type e--c coupling 695
Susanna C. Fagerholm and
Tiina J. Hilden and
Susanna M. Nurmi and
Carl G. Gahmberg Specific integrin $ \alpha $ and $ \beta
$ chain phosphorylations regulate LFA-1
activation through affinity-dependent
and -independent mechanisms . . . . . . 705
Matthew J. Naylor and
Na Li and
Julia Cheung and
Emma T. Lowe and
Elise Lambert and
Rebecca Marlow and
Pengbo Wang and
Franziska Schatzmann and
Timothy Wintermantel and
Günther Schüetz and
Alan R. Clarke and
Ulrich Mueller and
Nancy E. Hynes and
Charles H. Streuli Ablation of $ \beta $1 integrin in
mammary epithelium reveals a key role
for integrin in glandular morphogenesis
and differentiation . . . . . . . . . . 717
Kan Ding and
Martha Lopez-Burks and
José Antonio Sánchez-Duran and
Murray Korc and
Arthur D. Lander Growth factor--induced shedding of
syndecan-1 confers glypican-1 dependence
on mitogenic responses of cancer cells 729
Nicole LeBrasseur Centrosome-free basal MT organization ??
Nicole LeBrasseur Simple sensing in fibroblasts . . . . . ??
Nicole LeBrasseur The nesprin--IF connection . . . . . . . ??
Nicole LeBrasseur Out with the active $ \beta $-catenin ??
Nicole LeBrasseur Localized oxidation . . . . . . . . . . ??
William A. Wells Wiping the cellular slate clean . . . . ??
William A. Wells Difference drives division . . . . . . . ??
William A. Wells Squeezing dendritic necks . . . . . . . ??
William A. Wells Staying smart with age . . . . . . . . . ??
William A. Wells Catalytic dry run . . . . . . . . . . . ??
Kendall Powell Building a case for the chromosome
scaffold . . . . . . . . . . . . . . . . 758
Kendall Powell A big BiP on the radar screen . . . . . 759
Meghan E. Thorne and
Cara J. Gottardi Terminating Wnt signals . . . . . . . . 761
Michela Di Virgilio and
Jean Gautier Repair of double-strand breaks by
nonhomologous end joining in the absence
of Mre11 . . . . . . . . . . . . . . . . 765
Amethyst N. Gillis and
Scott Thomas and
Scott D. Hansen and
Kenneth B. Kaplan A novel role for the CBF3
kinetochore--scaffold complex in
regulating septin dynamics and
cytokinesis . . . . . . . . . . . . . . 773
Jolita Hendriksen and
Francois Fagotto and
Hella van der Velde and
Martijn van Schie and
Jasprien Noordermeer and
Maarten Fornerod RanBP3 enhances nuclear export of active
$ \beta $-catenin independently of CRM1 785
Kevin Wilhelmsen and
Sandy H. M. Litjens and
Ingrid Kuikman and
Ntambua Tshimbalanga and
Hans Janssen and
Iman van den Bout and
Karine Raymond and
Arnoud Sonnenberg Nesprin-3, a novel outer nuclear
membrane protein, associates with the
cytoskeletal linker protein plectin . . 799
Huidong Wang and
Anna Iacoangeli and
Daisy Lin and
Keith Williams and
Robert B. Denman and
Christopher U. T. Hellen and
Henri Tiedge Dendritic BC1 RNA in translational
control mechanisms . . . . . . . . . . . 811
Huaqing Cai and
Yueyi Zhang and
Marc Pypaert and
Lee Walker and
Susan Ferro-Novick Mutants in trs120 disrupt traffic from
the early endosome to the late Golgi . . 823
Feng-Xia Liang and
Maarten C. Bosland and
Hongying Huang and
Rok Romih and
Solange Baptiste and
Fang-Ming Deng and
Xue-Ru Wu and
Ellen Shapiro and
Tung-Tien Sun Cellular basis of urothelial squamous
metaplasia . . . . . . . . . . . . . . . 835
Amy Reilein and
Soichiro Yamada and
W. James Nelson Self-organization of an acentrosomal
microtubule network at the basal cortex
of polarized epithelial cells . . . . . 845
Giovanna Lalli and
Alan Hall Ral GTPases regulate neurite branching
through GAP-43 and the exocyst complex 857
Irene H. L. Hamelers and
Cristina Olivo and
Alexander E. E. Mertens and
D. Michiel Pegtel and
Rob A. van der Kammen and
Arnoud Sonnenberg and
John G. Collard The Rac activator Tiam1 is required for
$ \alpha $3$ \beta $1-mediated laminin-5
deposition, cell spreading, and cell
migration . . . . . . . . . . . . . . . 871
Ian C. Schneider and
Jason M. Haugh Quantitative elucidation of a distinct
spatial gradient-sensing mechanism in
fibroblasts . . . . . . . . . . . . . . 883
Ru Feng Wu and
You Cheng Xu and
Zhenyi Ma and
Fiemu E. Nwariaku and
George A. Sarosi and
Lance S. Terada Subcellular targeting of oxidants during
endothelial cell migration . . . . . . . 893
Rabiya S. Tuma Controlling division planes . . . . . . ??
Rabiya S. Tuma A gas pedal for replication? . . . . . . ??
Rabiya S. Tuma Moving in on desmosomes . . . . . . . . ??
Rabiya S. Tuma Anchoring under shear stress . . . . . . ??
Rabiya S. Tuma Regulating basal body replication . . . ??
Rabiya S. Tuma TCRs alive on the periphery . . . . . . ??
Rabiya S. Tuma Less p53 for life . . . . . . . . . . . ??
Rabiya S. Tuma G proteins find partners . . . . . . . . ??
Rabiya S. Tuma Fragile when condensed . . . . . . . . . ??
Rabiya S. Tuma History's influence on actin . . . . . . ??
Kendall Powell Sticking it out with tight junctions . . 916
Kendall Powell Microtubules turn over rapidly . . . . . 917
Anna Bielli and
Charles J. Haney and
Gavin Gabreski and
Simon C. Watkins and
Sergei I. Bannykh and
Meir Aridor Regulation of Sar1 NH$_2$ terminus by
GTP binding and hydrolysis promotes
membrane deformation to control COPII
vesicle fission . . . . . . . . . . . . 919
Malia B. Potts and
Allyson E. Vaughn and
Holly McDonough and
Cam Patterson and
Mohanish Deshmukh Reduced Apaf-1 levels in cardiomyocytes
engage strict regulation of apoptosis by
endogenous XIAP . . . . . . . . . . . . 925
Ikuo Nakamichi and
Diana M. Toivola and
Pavel Strnad and
Sara A. Michie and
Robert G. Oshima and
Hél\`ene Baribault and
M. Bishr Omary Keratin 8 overexpression promotes mouse
Mallory body formation . . . . . . . . . 931
Junichi Ikenouchi and
Mikio Furuse and
Kyoko Furuse and
Hiroyuki Sasaki and
Sachiko Tsukita and
Shoichiro Tsukita Tricellulin constitutes a novel barrier
at tricellular contacts of epithelial
cells . . . . . . . . . . . . . . . . . 939
Craig A. Leach and
W. Matthew Michael Ubiquitin\slash SUMO modification of
PCNA promotes replication fork
progression in \bionameXenopus laevis
egg extracts . . . . . . . . . . . . . . 947
David J. Dilworth and
Alan J. Tackett and
Richard S. Rogers and
Eugene C. Yi and
Rowan H. Christmas and
Jennifer J. Smith and
Andrew F. Siegel and
Brian T. Chait and
Richard W. Wozniak and
John D. Aitchison The mobile nucleoporin Nup2p and
chromatin-bound Prp20p function in
endogenous NPC-mediated transcriptional
control . . . . . . . . . . . . . . . . 955
Thomas Strahl and
Hiroko Hama and
Daryll B. DeWald and
Jeremy Thorner Yeast phosphatidylinositol $4$-kinase,
Pik1, has essential roles at the Golgi
and in the nucleus . . . . . . . . . . . 967
Christoph Reese and
Andreas Mayer Transition from hemifusion to pore
opening is rate limiting for vacuole
membrane fusion . . . . . . . . . . . . 981
Lucia Poggi and
Marta Vitorino and
Ichiro Masai and
William A. Harris Influences on neural lineage and mode of
division in the zebrafish retina in vivo 991
Ji-Yeon Shin and
Zhi-Hui Fang and
Zhao-Xue Yu and
Chuan-En Wang and
Shi-Hua Li and
Xiao-Jiang Li Expression of mutant huntingtin in glial
cells contributes to neuronal
excitotoxicity . . . . . . . . . . . . . 1001
Daniela Piazzolla and
Katrin Meissl and
Lucia Kucerova and
Cristina Rubiolo and
Manuela Baccarini Raf-1 sets the threshold of Fas
sensitivity by modulating Rok-$ \alpha $
signaling . . . . . . . . . . . . . . . 1013
Hanna Y. Irie and
Rachel V. Pearline and
Dorre Grueneberg and
Maximilian Hsia and
Preethi Ravichandran and
Nayantara Kothari and
Sridaran Natesan and
Joan S. Brugge Distinct roles of Akt1 and Akt2 in
regulating cell migration and
epithelial--mesenchymal transition . . . 1023
Yuhua Shang and
Che-Chia Tsao and
Martin A. Gorovsky Mutational analyses reveal a novel
function of the nucleotide-binding
domain of $ \gamma $-tubulin in the
regulation of basal body biogenesis . . 1035
Lisa M. Godsel and
Sherry N. Hsieh and
Evangeline V. Amargo and
Amanda E. Bass and
Lauren T. Pascoe-McGillicuddy and
Arthur C. Huen and
Meghan E. Thorne and
Claire A. Gaudry and
Jung K. Park and
Kyunghee Myung and
Robert D. Goldman and
Teng-Leong Chew and
Kathleen J. Green Desmoplakin assembly dynamics in four
dimensions . . . . . . . . . . . . . . . 1045
Yi Qin and
Christopher Capaldo and
Barry M. Gumbiner and
Ian G. Macara The mammalian Scribble polarity protein
regulates epithelial cell adhesion and
migration through E-cadherin . . . . . . 1061
Ronen Alon and
Sara W. Feigelson and
Eugenia Manevich and
David M. Rose and
Julia Schmitz and
Darryl R. Overby and
Eitan Winter and
Valentin Grabovsky and
Vera Shinder and
Benjamin D. Matthews and
Maya Sokolovsky-Eisenberg and
Donald E. Ingber and
Martin Benoit and
Mark H. Ginsberg $ \alpha_4 \beta_1 $-dependent adhesion
strengthening under mechanical strain is
regulated by paxillin association with
the $ \alpha_4$-cytoplasmic domain . . . 1073
Cecilia D'Alterio and
Dao D. D. Tran and
Maggie W. Y. Au Yeung and
Michael S. H. Hwang and
Michelle A. Li and
Claudia J. Arana and
Vikram K. Mulligan and
Mary Kubesh and
Praveer Sharma and
Maretta Chase and
Ulrich Tepass and
Dorothea Godt Correction . . . . . . . . . . . . . . . 1085
Nicole LeBrasseur Defaulty neurons . . . . . . . . . . . . ??
Nicole LeBrasseur Big bones in p53 mutants . . . . . . . . ??
Nicole LeBrasseur Xorbiting the spindle . . . . . . . . . ??
Nicole LeBrasseur Selective calcium blockade . . . . . . . ??
Nicole LeBrasseur Kar'ted to plus ends . . . . . . . . . . ??
William A. Wells Virtual adherens junctions . . . . . . . ??
William A. Wells Sending the advance party for metastases ??
William A. Wells Group effort from poliovirus . . . . . . ??
William A. Wells Remodeling replication . . . . . . . . . ??
William A. Wells Golgi directs dendritic traffic . . . . ??
Kendall Powell Filling in the gap . . . . . . . . . . . 6
Kendall Powell MAP 1C is a motor . . . . . . . . . . . 7
Alison J. North Seeing is believing? A beginners' guide
to practical pitfalls in image
acquisition . . . . . . . . . . . . . . 9
Eva Hannak and
Rebecca Heald Xorbit/CLASP links dynamic microtubules
to chromosomes in the \bionameXenopus
meiotic spindle . . . . . . . . . . . . 19
Jeffrey N. Molk and
E. D. Salmon and
Kerry Bloom Nuclear congression is driven by
cytoplasmic microtubule plus end
interactions in S. cerevisiae . . . . . 27
Melissa Crisp and
Qian Liu and
Kyle Roux and
J. B. Rattner and
Catherine Shanahan and
Brian Burke and
Phillip D. Stahl and
Didier Hodzic Coupling of the nucleus and cytoplasm:
Role of the LINC complex . . . . . . . . 41
Bianka L. Grosshans and
Anna Andreeva and
Akanksha Gangar and
Sherry Niessen and
John R. Yates and
Patrick Brennwald and
Peter Novick The yeast lgl family member Sro7p is an
effector of the secretory Rab GTPase
Sec4p . . . . . . . . . . . . . . . . . 55
Sébastien Léon and
Lan Zhang and
W. Hayes McDonald and
John Yates and
James M. Cregg and
Suresh Subramani Dynamics of the peroxisomal import cycle
of PpPex20p: Ubiquitin-dependent
localization and regulation . . . . . . 67
Simon R. Smukler and
Susan B. Runciman and
Shunbin Xu and
Derek van der Kooy Embryonic stem cells assume a primitive
neural stem cell fate in the absence of
extrinsic influences . . . . . . . . . . 79
Frédéric Relaix and
Didier Montarras and
Stéphane Zaffran and
Barbara Gayraud-Morel and
Didier Rocancourt and
Shahragim Tajbakhsh and
Ahmed Mansouri and
Ana Cumano and
Margaret Buckingham Pax3 and Pax7 have distinct and
overlapping functions in adult muscle
progenitor cells . . . . . . . . . . . . 91
Shihuan Kuang and
Sophie B. Chargé and
Patrick Seale and
Michael Huh and
Michael A. Rudnicki Distinct roles for Pax7 and Pax3 in
adult regenerative myogenesis . . . . . 103
Xueying Wang and
Hui-Yi Kua and
Yuanyu Hu and
Ke Guo and
Qi Zeng and
Qiang Wu and
Huck-Hui Ng and
Gerard Karsenty and
Benoit de Crombrugghe and
James Yeh and
Baojie Li p53 functions as a negative regulator of
osteoblastogenesis, osteoblast-dependent
osteoclastogenesis, and bone remodeling 115
Fei Zhong and
Michael C. Davis and
Karen S. McColl and
Clark W. Distelhorst Bcl-2 differentially regulates Ca$^{2+}$
signals according to the strength of T
cell receptor activation . . . . . . . . 127
Anneli Gebhardt and
Michaela Frye and
Steffi Herold and
Salvador Aznar Benitah and
Kristin Braun and
Birgit Samans and
Fiona M. Watt and
Hans-Peter Elsässer and
Martin Eilers Myc regulates keratinocyte adhesion and
differentiation via complex formation
with Miz1 . . . . . . . . . . . . . . . 139
Rickmer Braren and
Huiqing Hu and
Yung Hae Kim and
Hilary E. Beggs and
Louis F. Reichardt and
Rong Wang Endothelial FAK is essential for
vascular network stability, cell
survival, and lamellipodial formation 151
Jacques P. Zappulla and
Patrice Dubreuil and
Sabine Desbois and
Sébastien Létard and
Nadine Ben Hamouda and
Marc Daëron and
Georges Delsol and
Michel Arock and
Roland S. Liblau Mastocytosis in mice expressing human
Kit receptor with the activating
Asp816Val mutation . . . . . . . . . . . ??
Clifford C. Taggart and
Sally-Ann Cryan and
Sinead Weldon and
Aileen Gibbons and
Catherine M. Greene and
Emer Kelly and
Teck Boon Low and
Shane J. O'Neill and
Noel G. McElvaney Secretory leucoprotease inhibitor binds
to NF-$ \kappa $B binding sites in
monocytes and inhibits p65 binding . . . ??
Rabiya S. Tuma Repair at the nuclear periphery . . . . 164
Rabiya S. Tuma Stat3 stabilizes microtubules . . . . . ??
Rabiya S. Tuma Sometimes size does matter . . . . . . . 165
Rabiya S. Tuma NO induces myoblast fusion . . . . . . . ??
Rabiya S. Tuma Mobile genes . . . . . . . . . . . . . . ??
Kendall Powell Lipid raft idea is floated . . . . . . . 166
Mitch Leslie Making tendons . . . . . . . . . . . . . 167
Weiping Yuan and
Tina M. Leisner and
Andrew W. McFadden and
Zhengyan Wang and
Mark K. Larson and
Shantres Clark and
Christel Boudignon-Proudhon and
Stephen C.-T. Lam and
Leslie V. Parise CIB1 is an endogenous inhibitor of
agonist-induced integrin $ \alpha $IIb$
\beta $3 activation . . . . . . . . . . 169
Jill M. Brown and
Joanne Leach and
Joyce E. Reittie and
Ann Atzberger and
Jane Lee-Prudhoe and
William G. Wood and
Douglas R. Higgs and
Francisco J. Iborra and
Veronica J. Buckle Coregulated human globin genes are
frequently in spatial proximity when
active . . . . . . . . . . . . . . . . . 177
Pierre Therizols and
Cécile Fairhead and
Ghislain G. Cabal and
Auguste Genovesio and
Jean-Christophe Olivo-Marin and
Bernard Dujon and
Emmanuelle Fabre Telomere tethering at the nuclear
periphery is essential for efficient DNA
double strand break repair in
subtelomeric region . . . . . . . . . . 189
Stefan J. Marciniak and
Lidia Garcia-Bonilla and
Junjie Hu and
Heather P. Harding and
David Ron Activation-dependent substrate
recruitment by the eukaryotic
translation initiation factor 2 kinase
PERK . . . . . . . . . . . . . . . . . . 201
Ikjin Kim and
Jungmi Ahn and
Chang Liu and
Kaori Tanabe and
Jennifer Apodaca and
Tadashi Suzuki and
Hai Rao The Png1--Rad23 complex regulates
glycoprotein turnover . . . . . . . . . 211
Bernhard Goetze and
Fabian Tuebing and
Yunli Xie and
Mario M. Dorostkar and
Sabine Thomas and
Ulrich Pehl and
Stefan Boehm and
Paolo Macchi and
Michael A. Kiebler The brain-specific double-stranded
RNA-binding protein Staufen2 is required
for dendritic spine morphogenesis . . . 221
Addolorata Pisconti and
Silvia Brunelli and
Monica Di Padova and
Clara De Palma and
Daniela Deponti and
Silvia Baesso and
Vittorio Sartorelli and
Giulio Cossu and
Emilio Clementi Follistatin induction by nitric oxide
through cyclic GMP: a tightly regulated
signaling pathway that controls myoblast
fusion . . . . . . . . . . . . . . . . . 233
Dominic Chi Hiung Ng and
Bao Hong Lin and
Cheh Peng Lim and
Guochang Huang and
Tong Zhang and
Valeria Poli and
Xinmin Cao Stat3 regulates microtubules by
antagonizing the depolymerization
activity of stathmin . . . . . . . . . . 245
Jérôme M. Goffin and
Philippe Pittet and
Gabor Csucs and
Jost W. Lussi and
Jean-Jacques Meister and
Boris Hinz Focal adhesion size controls
tension-dependent recruitment of $
\alpha $-smooth muscle actin to stress
fibers . . . . . . . . . . . . . . . . . 259
Kazuya Tsujita and
Shiro Suetsugu and
Nobunari Sasaki and
Masahiro Furutani and
Tsukasa Oikawa and
Tadaomi Takenawa Coordination between the actin
cytoskeleton and membrane deformation by
a novel membrane tubulation domain of
PCH proteins is involved in endocytosis 269
Xue Han and
Meyer B. Jackson Structural transitions in the synaptic
SNARE complex during Ca$^{2+}$-triggered
exocytosis . . . . . . . . . . . . . . . 281
Jeffrey S. Van Komen and
Xiaoyang Bai and
Brenton L. Scott and
James A. McNew An intramolecular t--SNARE complex
functions in vivo without the syntaxin
NH$_2$-terminal regulatory domain . . . 295
Laurence Abrami and
Stephen H. Leppla and
F. Gisou van der Goot Receptor palmitoylation and
ubiquitination regulate anthrax toxin
endocytosis . . . . . . . . . . . . . . 309
Masatoshi Takeichi Shoichiro Tsukita: a life exploring the
molecular architecture of the tight
junction . . . . . . . . . . . . . . . . 321
Nicole LeBrasseur Motherly loss ends cell cycle . . . . . 324
Nicole LeBrasseur Dividing to their own beat . . . . . . . ??
Nicole LeBrasseur Newt insight into regeneration . . . . . 325
Nicole LeBrasseur mRNAs held back . . . . . . . . . . . . ??
Nicole LeBrasseur Coping strategies weaken cells . . . . . ??
Alla Katsnelson Hyperdynamic proteins keep stem cells on
their toes . . . . . . . . . . . . . . . 326
Alla Katsnelson Making HoxD waves . . . . . . . . . . . ??
Alla Katsnelson Two-speed cell specification . . . . . . 327
Alla Katsnelson E. coli squeezed into action . . . . . . ??
Alla Katsnelson Aging on the clock . . . . . . . . . . . ??
Mitch Leslie Centrosome choreography . . . . . . . . 328
Mitch Leslie Passenger proteins check in . . . . . . 329
John A. Cooper and
Scott A. Nelson Checkpoint control of mitotic exit ---
do budding yeast mind the GAP? . . . . . 331
Roberta Fraschini and
Claudio D'Ambrosio and
Marianna Venturetti and
Giovanna Lucchini and
Simonetta Piatti Disappearance of the budding yeast
Bub2--Bfa1 complex from the mother-bound
spindle pole contributes to mitotic exit 335
Amy S. Gladfelter and
A. Katrin Hungerbuehler and
Peter Philippsen Asynchronous nuclear division cycles in
multinucleated cells . . . . . . . . . . 347
Ulrike Gruneberg and
Rüdiger Neef and
Xiuling Li and
Eunice H. Y. Chan and
Ravindra B. Chalamalasetty and
Erich A. Nigg and
Francis A. Barr KIF14 and citron kinase act together to
promote efficient cytokinesis . . . . . 363
Ute Schmidt and
Karsten Richter and
Axel Bernhard Berger and
Peter Lichter In vivo BiFC analysis of Y14 and NXF1
mRNA export complexes: preferential
localization within and around SC35
domains . . . . . . . . . . . . . . . . 373
Yukako Oda and
Tetsuya Okada and
Hiderou Yoshida and
Randal J. Kaufman and
Kazuhiro Nagata and
Kazutoshi Mori Derlin-2 and Derlin-3 are regulated by
the mammalian unfolded protein response
and are required for ER-associated
degradation . . . . . . . . . . . . . . 383
James P. Bridges and
Yan Xu and
Cheng-Lun Na and
Hector R. Wong and
Timothy E. Weaver Adaptation and increased susceptibility
to infection associated with
constitutive expression of misfolded
SP--C . . . . . . . . . . . . . . . . . 395
Xuan Wang and
Diana Bolotin and
David H. Chu and
Lisa Polak and
Trevor Williams and
Elaine Fuchs AP-2$ \alpha $: a regulator of EGF
receptor signaling and proliferation in
skin epidermis . . . . . . . . . . . . . 409
Sangmyung Rhee and
Frederick Grinnell P21-activated kinase 1: convergence
point in PDGF- and LPA-stimulated
collagen matrix contraction by human
fibroblasts . . . . . . . . . . . . . . 423
Jamie I. Morrison and
Sara Lööf and
Pingping He and
András Simon Salamander limb regeneration involves
the activation of a multipotent skeletal
muscle satellite cell population . . . . 433
Christoph Maas and
Nadia Tagnaouti and
Sven Loebrich and
Bardo Behrend and
Corinna Lappe-Siefke and
Matthias Kneussel Neuronal cotransport of glycine receptor
and the scaffold protein gephyrin . . . 441
Vanessa Schubert and
Jorge Santos Da Silva and
Carlos G. Dotti Localized recruitment and activation of
RhoA underlies dendritic spine
morphology in a glutamate
receptor-dependent manner . . . . . . . 453
Xinghua Yin and
Rena C. Baek and
Daniel A. Kirschner and
Alan Peterson and
Yasuhisa Fujii and
Klaus-Armin Nave and
Wendy B. Macklin and
Bruce D. Trapp Evolution of a neuroprotective function
of central nervous system myelin . . . . 469
Rabiya S. Tuma Unspliced regulator . . . . . . . . . . 480
Rabiya S. Tuma Making $ \gamma $-tubulin ring . . . . . ??
Rabiya S. Tuma A slow death . . . . . . . . . . . . . . 481
Rabiya S. Tuma Linking Huntingtin to motility . . . . . ??
Rabiya S. Tuma Aneuploidy does not equal aging . . . . ??
Nicole LeBrasseur Spreading mitochondria . . . . . . . . . 482
Nicole LeBrasseur Monooriented in the middle . . . . . . . ??
Nicole LeBrasseur Specialized chaperones . . . . . . . . . 483
Nicole LeBrasseur XX meetings . . . . . . . . . . . . . . ??
Nicole LeBrasseur APC's order of business . . . . . . . . ??
Kendall Powell BFA sends proteins back . . . . . . . . 484
Mitch Leslie Cadherin as a tumor suppressor . . . . . 485
Mitch Leslie Active neuronal death . . . . . . . . . ??
Nicole LeBrasseur and
Alla Katsnelson Golden Gate Cells: The American Society
for Cell Biology San Francisco, CA
December 10--14, 2005 . . . . . . . . . 486
Wilma A. Hofmann and
Primal de Lanerolle Nuclear actin: to polymerize or not to
polymerize . . . . . . . . . . . . . . . 495
Qingyu Qin and
Ryoko Inatome and
Azusa Hotta and
Masaki Kojima and
Hirohei Yamamura and
Hirokazu Hirai and
Toshihiro Yoshizawa and
Hirofumi Tanaka and
Kiyoko Fukami and
Shigeru Yanagi A novel GTPase, CRAG, mediates
promyelocytic leukemia
protein--associated nuclear body
formation and degradation of expanded
polyglutamine protein . . . . . . . . . 497
Laurence Haren and
Marie-Hél\`ene Remy and
Ingrid Bazin and
Isabelle Callebaut and
Michel Wright and
Andreas Merdes NEDD1-dependent recruitment of the $
\gamma $-tubulin ring complex to the
centrosome is necessary for centriole
duplication and spindle assembly . . . . 505
Christel Vérollet and
Nathalie Colombié and
Thomas Daubon and
Henri-Marc Bourbon and
Michel Wright and
Brigitte Raynaud-Messina Drosophila melanogaster $ \gamma $-TuRC
is dispensable for targeting $ \gamma
$-tubulin to the centrosome and
microtubule nucleation . . . . . . . . . 517
Darren J. Baker and
Karthik B. Jeganathan and
Liviu Malureanu and
Carmen Perez-Terzic and
Andre Terzic and
Jan M. A. van Deursen Early aging--associated phenotypes in
Bub3/Rae1 haploinsufficient mice . . . . 529
Darin McDonald and
Gustavo Carrero and
Christi Andrin and
Gerda de Vries and
Michael J. Hendzel Nucleoplasmic $ \beta $-actin exists in
a dynamic equilibrium between
low-mobility polymeric species and
rapidly diffusing populations . . . . . 541
Ann E. Frazier and
Rebecca D. Taylor and
David U. Mick and
Bettina Warscheid and
Nadine Stoepel and
Helmut E. Meyer and
Michael T. Ryan and
Bernard Guiard and
Peter Rehling Mdm38 interacts with ribosomes and is a
component of the mitochondrial protein
export machinery . . . . . . . . . . . . 553
Hiderou Yoshida and
Masaya Oku and
Mie Suzuki and
Kazutoshi Mori pXBP1(U) encoded in XBP1 pre-mRNA
negatively regulates unfolded protein
response activator pXBP1(S) in mammalian
ER stress response . . . . . . . . . . . 565
Trent P. Munro and
Sunjong Kwon and
Bruce J. Schnapp and
Daniel St Johnston A repeated IMP-binding motif controls
oskar mRNA translation and anchoring
independently of \bionameDrosophila
melanogaster IMP . . . . . . . . . . . . 577
Masataka Hoshino and
Mei-ling Qi and
Natsue Yoshimura and
Tomoyuki Miyashita and
Kazuhiko Tagawa and
Yo-ichi Wada and
Yasushi Enokido and
Shigeki Marubuchi and
Phoebe Harjes and
Nobutaka Arai and
Kiyomitsu Oyanagi and
Giovanni Blandino and
Marius Sudol and
Tina Rich and
Ichiro Kanazawa and
Erich E. Wanker and
Minoru Saitoe and
Hitoshi Okazawa Transcriptional repression induces a
slowly progressive atypical neuronal
death associated with changes of YAP
isoforms and p73 . . . . . . . . . . . . 589
Arun Pal and
Fedor Severin and
Barbara Lommer and
Anna Shevchenko and
Marino Zerial Huntingtin-HAP40 complex is a novel Rab5
effector that regulates early endosome
motility and is up-regulated in
Huntington's disease . . . . . . . . . . 605
Jean-Cheng Kuo and
Won-Jing Wang and
Chung-Chen Yao and
Pei-Rung Wu and
Ruey-Hwa Chen The tumor suppressor DAPK inhibits cell
motility by blocking the
integrin-mediated polarity pathway . . . 619
Xufeng S. Wu and
Grace L. Tsan and
John A. Hammer Correction . . . . . . . . . . . . . . . 633
Huidong Wang and
Anna Iacoangeli and
Daisy Lin and
Keith Williams and
Robert B. Denman and
Christopher U. T. Hellen and
Henri Tiedge Correction . . . . . . . . . . . . . . . 635
Nicole LeBrasseur Tandem transcript translation . . . . . 638
Nicole LeBrasseur The Repo--Man bringeth . . . . . . . . . ??
Nicole LeBrasseur Who Pix up Rac1? . . . . . . . . . . . . 639
Nicole LeBrasseur Par-3 for the cofilin course . . . . . . ??
Nicole LeBrasseur Insulin pathway clears aggregates . . . ??
William A. Wells Sympathy for stem cells . . . . . . . . 640
William A. Wells Tortoise puts brake on hare . . . . . . ??
William A. Wells VWF springs into action . . . . . . . . 641
William A. Wells Trip to the pore . . . . . . . . . . . . ??
William A. Wells Metabolic waste smoothes consumption . . ??
Kendall Powell ECM signals ECM degradation . . . . . . 642
William A. Wells Microtubules get dynamic . . . . . . . . 643
Richard A. Kahn and
Jacqueline Cherfils and
Marek Elias and
Ruth C. Lovering and
Sean Munro and
Annette Schurmann Nomenclature for the human Arf family of
GTP-binding proteins: ARF, ARL, and SAR
proteins . . . . . . . . . . . . . . . . 645
Xin Xiang A +TIP for a smooth trip . . . . . . . . 651
Dileep Varma and
Denis L. Dujardin and
Stephanie A. Stehman and
Richard B. Vallee Role of the kinetochore/cell cycle
checkpoint protein ZW10 in interphase
cytoplasmic dynein function . . . . . . 655
James E. Evans and
Joshua J. Snow and
Amy L. Gunnarson and
Guangshuo Ou and
Henning Stahlberg and
Kent L. McDonald and
Jonathan M. Scholey Functional modulation of IFT kinesins
extends the sensory repertoire of
ciliated neurons in
\bionameCaenorhabditis elegans . . . . . 663
Xinyu Chen and
Ian G. Macara Par-3 mediates the inhibition of LIM
kinase 2 to regulate cofilin
phosphorylation and tight junction
assembly . . . . . . . . . . . . . . . . 671
Laura Trinkle-Mulcahy and
Jens Andersen and
Yun Wah Lam and
Greg Moorhead and
Matthias Mann and
Angus I. Lamond Repo-Man recruits PP1$ \gamma $ to
chromatin and is essential for cell
viability . . . . . . . . . . . . . . . 679
Jason E. Duex and
Fusheng Tang and
Lois S. Weisman The Vac14p--Fig4p complex acts
independently of Vac7p and couples
PI3,5P$_2$ synthesis and turnover . . . 693
Ishara Azmi and
Brian Davies and
Christian Dimaano and
Johanna Payne and
Debra Eckert and
Markus Babst and
David J. Katzmann Recycling of ESCRTs by the AAA--ATPase
Vps4 is regulated by a conserved VSL
region in Vta1 . . . . . . . . . . . . . 705
Ai Yamamoto and
M. Laura Cremona and
James E. Rothman Autophagy-mediated clearance of
huntingtin aggregates triggered by the
insulin-signaling pathway . . . . . . . 719
Jennifer R. Levy and
Charlotte J. Sumner and
Juliane P. Caviston and
Mariko K. Tokito and
Srikanth Ranganathan and
Lee A. Ligon and
Karen E. Wallace and
Bernadette H. LaMonte and
George G. Harmison and
Imke Puls and
Kenneth H. Fischbeck and
Erika L. F. Holzbaur A motor neuron disease--associated
mutation in p150$^{\rm Glued}$ perturbs
dynactin function and induces protein
aggregation . . . . . . . . . . . . . . 733
Lynne Chang and
Yaron Shav-Tal and
Tatjana Trcek and
Robert H. Singer and
Robert D. Goldman Assembling an intermediate filament
network by dynamic cotranslation . . . . 747
Jean Paul ten Klooster and
Zahara M. Jaffer and
Jonathan Chernoff and
Peter L. Hordijk Targeting and activation of Rac1 are
mediated by the exchange factor $ \beta
$-Pix . . . . . . . . . . . . . . . . . 759
Laura M. Hoffman and
Christopher C. Jensen and
Susanne Kloeker and
C.-L. Albert Wang and
Masaaki Yoshigi and
Mary C. Beckerle Genetic ablation of zyxin causes
Mena/VASP mislocalization, increased
motility, and deficits in actin
remodeling . . . . . . . . . . . . . . . 771
Rabiya S. Tuma DNA stays put . . . . . . . . . . . . . 784
Rabiya S. Tuma Knocking out malaria in one punch . . . ??
Rabiya S. Tuma Exosomes at the plasma membrane . . . . 785
Rabiya S. Tuma Neighbors control trafficking . . . . . ??
Rabiya S. Tuma Exit without separase . . . . . . . . . ??
Kendall Powell Anchored telomeres get longer . . . . . 786
Kendall Powell Killer K--Ras . . . . . . . . . . . . . ??
Kendall Powell Skating on MTs . . . . . . . . . . . . . 787
Kendall Powell Virus diverts checkpoint . . . . . . . . ??
Kendall Powell Hungry for better memory . . . . . . . . ??
Kendall Powell Chromosome snatching by lateral
microtubules . . . . . . . . . . . . . . 788
Mitch Leslie In vitro nuclear import . . . . . . . . 789
A. Gregory Matera Drosophila Cajal bodies: accessories not
included . . . . . . . . . . . . . . . . 791
Gerard P. Zambetti and
Edwin M. Horwitz and
Ernestina Schipani Skeletons in the p53 tumor suppressor
closet: genetic evidence that p53 blocks
bone differentiation and development . . 795
Tatiana Boiko and
Bettina Winckler Myelin under construction --- teamwork
required . . . . . . . . . . . . . . . . 799
Paul Anderson and
Nancy Kedersha RNA granules . . . . . . . . . . . . . . 803
Kathryn Mills and
Tasman Daish and
Kieran F. Harvey and
Cathie M. Pfleger and
Iswar K. Hariharan and
Sharad Kumar The \bionameDrosophila melanogaster
Apaf-1 homologue ARK is required for
most, but not all, programmed cell death 809
Firdous A. Khanday and
Lakshmi Santhanam and
Kenji Kasuno and
Tohru Yamamori and
Asma Naqvi and
Jeremy DeRicco and
Artem Bugayenko and
Ilwola Mattagajasingh and
Andrea Disanza and
Giorgio Scita and
Kaikobad Irani Sos-mediated activation of rac1 by
p66shc . . . . . . . . . . . . . . . . . 817
Michael J. Kruhlak and
Arkady Celeste and
Graham Dellaire and
Oscar Fernandez-Capetillo and
Waltraud G. Müller and
James G. McNally and
David P. Bazett-Jones and
André Nussenzweig Changes in chromatin structure and
mobility in living cells at sites of DNA
double-strand breaks . . . . . . . . . . 823
Kazuki Kumada and
Ryoji Yao and
Tokuichi Kawaguchi and
Mika Karasawa and
Yutaka Hoshikawa and
Koji Ichikawa and
Yoshinobu Sugitani and
Issei Imoto and
Johji Inazawa and
Minoru Sugawara and
Mitsuhiro Yanagida and
Tetsuo Noda The selective continued linkage of
centromeres from mitosis to interphase
in the absence of mammalian separase . . 835
Karin G. Wirth and
Gordana Wutz and
Nobuaki R. Kudo and
Chantal Desdouets and
Anders Zetterberg and
Shahryar Taghybeeglu and
Janina Seznec and
Germain M. Ducos and
Romeo Ricci and
Nicole Firnberg and
Jan-Michael Peters and
Kim Nasmyth Separase: a universal trigger for sister
chromatid disjunction but not chromosome
cycle progression . . . . . . . . . . . 847
Jessica D. Tytell and
Peter K. Sorger Analysis of kinesin motor function at
budding yeast kinetochores . . . . . . . 861
Ji-Long Liu and
Christine Murphy and
Michael Buszczak and
Sarah Clatterbuck and
Robyn Goodman and
Joseph G. Gall The \bionameDrosophila melanogaster
Cajal body . . . . . . . . . . . . . . . 875
Yoav D. Shaul and
Rony Seger ERK1c regulates Golgi fragmentation
during mitosis . . . . . . . . . . . . . 885
Brian M. Cooke and
Donna W. Buckingham and
Fiona K. Glenister and
Kate M. Fernandez and
Lawrence H. Bannister and
Matthias Marti and
Narla Mohandas and
Ross L. Coppel A Maurer's cleft-associated protein is
essential for expression of the major
malaria virulence antigen on the surface
of infected red blood cells . . . . . . 899
Christopher J. Lengner and
Heather A. Steinman and
James Gagnon and
Thomas W. Smith and
Janet E. Henderson and
Barbara E. Kream and
Gary S. Stein and
Jane B. Lian and
Stephen N. Jones Osteoblast differentiation and skeletal
development are regulated by Mdm2--p53
signaling . . . . . . . . . . . . . . . 909
Amy M. Booth and
Yi Fang and
Jonathan K. Fallon and
Jr-Ming Yang and
James E. K. Hildreth and
Stephen J. Gould Exosomes and HIV Gag bud from
endosome-like domains of the T cell
plasma membrane . . . . . . . . . . . . 923
Katarina Trajkovic and
Ajit Singh Dhaunchak and
José T. Goncalves and
Dirk Wenzel and
Anja Schneider and
Gertrude Bunt and
Klaus-Armin Nave and
Mikael Simons Neuron to glia signaling triggers myelin
membrane exocytosis from endosomal
storage sites . . . . . . . . . . . . . 937
James E. Evans and
Joshua J. Snow and
Amy L. Gunnarson and
Guangshuo Ou and
Henning Stahlberg and
Kent L. McDonald and
Jonathan M. Scholey Correction . . . . . . . . . . . . . . . 949
Pierre Therizols and
Cécile Fairhead and
Ghislain G. Cabal and
Auguste Genovesio and
Jean-Christophe Olivo-Marin and
Bernard Dujon and
Emmanuelle Fabre Correction . . . . . . . . . . . . . . . 951
Ji-Yeon Shin and
Zhi-Hui Fang and
Zhao-Xue Yu and
Chuan-En Wang and
Shi-Hua Li and
Xiao-Jiang Li Correction . . . . . . . . . . . . . . . 953
Nicole LeBrasseur Direct is correct . . . . . . . . . . . 956
Nicole LeBrasseur A MAP's stabilizing mechanism . . . . . ??
Nicole LeBrasseur Escaping a checkpoint . . . . . . . . . 957
Nicole LeBrasseur Serum keeps order in the wound . . . . . ??
Nicole LeBrasseur Neurons survive with NCS-1 . . . . . . . ??
William A. Wells Analogue brains . . . . . . . . . . . . 958
William A. Wells Curing TB with sunlight . . . . . . . . ??
William A. Wells Stepwise receptor activation . . . . . . 959
William A. Wells Nuclear actin filaments . . . . . . . . ??
William A. Wells Kinetochore to order . . . . . . . . . . ??
Mitch Leslie Skeleton crew . . . . . . . . . . . . . 960
Mitch Leslie Cyclin localization controls activity 961
Sebastian Schuck and
Kai Simons Controversy fuels trafficking of
GPI-anchored proteins . . . . . . . . . 963
Piergiorgio Percipalle and
Neus Visa Molecular functions of nuclear actin in
transcription . . . . . . . . . . . . . 967
Jonathan M. Lee and
Shoukat Dedhar and
Raghu Kalluri and
Erik W. Thompson The epithelial--mesenchymal transition:
new insights in signaling, development,
and disease . . . . . . . . . . . . . . 973
Chika Katagiri and
Jotaro Nakanishi and
Kuniko Kadoya and
Toshihiko Hibino Serpin squamous cell carcinoma antigen
inhibits UV-induced apoptosis via
suppression of c--JUN NH$_2$-terminal
kinase . . . . . . . . . . . . . . . . . 983
Mary L. Preuss and
Aaron J. Schmitz and
Julie M. Thole and
Heather K. S. Bonner and
Marisa S. Otegui and
Erik Nielsen A role for the RabA4b effector protein
PI-4K$ \beta $1 in polarized expansion
of root hair cells in Arabidopsis
thaliana . . . . . . . . . . . . . . . . 991
Antonia H. Holway and
Seung-Hwan Kim and
Adriana La Volpe and
W. Matthew Michael Checkpoint silencing during the DNA
damage response in
\bionameCaenorhabditis elegans embryos 999
Jawdat Al-Bassam and
Mark van Breugel and
Stephen C. Harrison and
Anthony Hyman Stu2p binds tubulin and undergoes an
open-to-closed conformational change . . 1009
Simona Paladino and
Thomas Pocard and
Maria Agata Catino and
Chiara Zurzolo GPI-anchored proteins are directly
targeted to the apical surface in fully
polarized MDCK cells . . . . . . . . . . 1023
Wei Hua and
David Sheff and
Derek Toomre and
Ira Mellman Vectorial insertion of apical and
basolateral membrane proteins in
polarized epithelial cells revealed by
quantitative $3$D live cell imaging . . 1035
Jae-Hyuck Shim and
Changchun Xiao and
Matthew S. Hayden and
Ki-Young Lee and
E. Sergio Trombetta and
Marc Pypaert and
Atsuki Nara and
Tamotsu Yoshimori and
Bettina Wilm and
Hediye Erdjument-Bromage and
Paul Tempst and
Brigid L. M. Hogan and
Ira Mellman and
Sankar Ghosh CHMP5 is essential for late endosome
function and down-regulation of receptor
signaling during mouse embryogenesis . . 1045
Miguel A. Sanjuan and
Navin Rao and
Kuei-Tai A. Lai and
Yin Gu and
Siquan Sun and
Anja Fuchs and
Wai-Ping Fung-Leung and
Marco Colonna and
Lars Karlsson CpG-induced tyrosine phosphorylation
occurs via a TLR9-independent mechanism
and is required for cytokine secretion 1057
Agn\`es Wiedemann and
Jayesh C. Patel and
Jenson Lim and
Andy Tsun and
Yvette van Kooyk and
Emmanuelle Caron Two distinct cytoplasmic regions of the
$ \beta_2 $ integrin chain regulate RhoA
function during phagocytosis . . . . . . 1069
Tomoe Y. Nakamura and
Andreas Jeromin and
George Smith and
Hideaki Kurushima and
Hitoshi Koga and
Yusaku Nakabeppu and
Shigeo Wakabayashi and
Junichi Nabekura Novel role of neuronal Ca$^{2+}$
sensor-1 as a survival factor
up-regulated in injured neurons . . . . 1081
Balaji Bandyopadhyay and
Jianhua Fan and
Shengxi Guan and
Yong Li and
Mei Chen and
David T. Woodley and
Wei Li A ``traffic control'' role for TGF$
\beta $3: orchestrating dermal and
epidermal cell motility during wound
healing . . . . . . . . . . . . . . . . 1093
Rabiya S. Tuma Lamins for differentiation . . . . . . . 2
Rabiya S. Tuma An eye on cone outer segments . . . . . ??
Rabiya S. Tuma Ubiquitin tug--O--war . . . . . . . . . 3
Rabiya S. Tuma Endosome signaling . . . . . . . . . . . ??
Rabiya S. Tuma Unscrambling secretion . . . . . . . . . ??
Nicole LeBrasseur The shape of things to ingest . . . . . 4
Nicole LeBrasseur A new function for mitochondria . . . . ??
Nicole LeBrasseur Kinesin switch in neurites . . . . . . . 5
Nicole LeBrasseur Hedgehog makes giant brains . . . . . . ??
Mitch Leslie The Hunting of the snRNP . . . . . . . . 6
Mitch Leslie ECM determines fate . . . . . . . . . . ??
Kendall Powell The kinetochore uncoiled . . . . . . . . 7
Susan L. Kline and
Iain M. Cheeseman and
Tetsuya Hori and
Tatsuo Fukagawa and
Arshad Desai The human Mis12 complex is required for
kinetochore assembly and proper
chromosome segregation . . . . . . . . . 9
Nico P. Dantuma and
Tom A. M. Groothuis and
Florian A. Salomons and
Jacques Neefjes A dynamic ubiquitin equilibrium couples
proteasomal activity to chromatin
remodeling . . . . . . . . . . . . . . . 19
Takamune T. Saito and
Daisuke Okuzaki and
Hiroshi Nojima Mcp5, a meiotic cell cortex protein, is
required for nuclear movement mediated
by dynein and microtubules in fission
yeast . . . . . . . . . . . . . . . . . 27
Tina Gill and
Jason Aulds and
Mark E. Schmitt A specialized processing body that is
temporally and asymmetrically regulated
during the cell cycle in
\bionameSaccharomyces cerevisiae . . . . 35
Katsuhiko Hata and
Masashi Fujitani and
Yuichi Yasuda and
Hideo Doya and
Tomoko Saito and
Satoru Yamagishi and
Bernhard K. Mueller and
Toshihide Yamashita RGMa inhibition promotes axonal growth
and recovery after spinal cord injury 47
Rafal Farjo and
Jeff S. Skaggs and
Barbara A. Nagel and
Alexander B. Quiambao and
Zack A. Nash and
Steven J. Fliesler and
Muna I. Naash Retention of function without normal
disc morphogenesis occurs in cone but
not rod photoreceptors . . . . . . . . . 59
Usha Acharya and
Michael Beth Edwards and
Ramon A. Jorquera and
Hugo Silva and
Kunio Nagashima and
Pedro Labarca and
Jairaj K. Acharya Drosophila melanogaster Scramblases
modulate synaptic transmission . . . . . 69
Daniela Dorner and
Sylvia Vlcek and
Nicole Foeger and
Andreas Gajewski and
Christian Makolm and
Josef Gotzmann and
Christopher J. Hutchison and
Roland Foisner Lamina-associated polypeptide 2$ \alpha
$ regulates cell cycle progression and
differentiation via the
retinoblastoma--E2F pathway . . . . . . 83
Elaine S. Seto and
Hugo J. Bellen Internalization is required for proper
Wingless signaling in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 95
Sumana Raychaudhuri and
Young Jun Im and
James H. Hurley and
William A. Prinz Nonvesicular sterol movement from plasma
membrane to ER requires
oxysterol-binding protein--related
proteins and phosphoinositides . . . . . 107
Konrad Krzewski and
Xi Chen and
Jordan S. Orange and
Jack L. Strominger Formation of a WIP-, WASp-, actin-, and
myosin IIA--containing multiprotein
complex in activated NK cells and its
alteration by KIR inhibitory signaling 121
Nigel J. Waterhouse and
Vivien R. Sutton and
Karin A. Sedelies and
Annette Ciccone and
Misty Jenkins and
Stephen J. Turner and
Phillip I. Bird and
Joseph A. Trapani Cytotoxic T lymphocyte--induced killing
in the absence of granzymes A and B is
unique and distinct from both apoptosis
and perforin-dependent lysis . . . . . . 133
Nicole LeBrasseur Spill and kill . . . . . . . . . . . . . 146
Nicole LeBrasseur Flux without sliding . . . . . . . . . . ??
Nicole LeBrasseur Repair road map . . . . . . . . . . . . 147
Nicole LeBrasseur To each nucleus its own ER . . . . . . . ??
William A. Wells The physics of chaperones . . . . . . . 148
William A. Wells Outdoor decision-making . . . . . . . . ??
William A. Wells Immune to weight loss . . . . . . . . . 149
William A. Wells Mixed-up DNA . . . . . . . . . . . . . . ??
William A. Wells Stressful betrayal . . . . . . . . . . . ??
Mitch Leslie Dying on cue . . . . . . . . . . . . . . 150
Mitch Leslie Integrin signal transduction . . . . . . ??
Mitch Leslie Hold on for dear life . . . . . . . . . 151
Kendall Powell An unattached kinetochore screams
``Wait!'' . . . . . . . . . . . . . . . 152
Hongtao Yu Structural activation of Mad2 in the
mitotic spindle checkpoint: the
two-state Mad2 model versus the Mad2
template model . . . . . . . . . . . . . 153
Carolyn J. Decker and
Roy Parker CAR-1 and Trailer hitch: driving mRNP
granule function at the ER? . . . . . . 159
Mohamed Lamkanfi and
Wim Declercq and
Tom Vanden Berghe and
Peter Vandenabeele Caspases leave the beaten track:
caspase-mediated activation of NF-$
\kappa $B . . . . . . . . . . . . . . . 165
Lisa A. Cameron and
Ge Yang and
Daniela Cimini and
Julie C. Canman and
Olga Kisurina-Evgenieva and
Alexey Khodjakov and
Gaudenz Danuser and
E. D. Salmon Kinesin $5$--independent poleward flux
of kinetochore microtubules in PtK1
cells . . . . . . . . . . . . . . . . . 173
Shan Yan and
Howard D. Lindsay and
W. Matthew Michael Direct requirement for Xmus101 in
ATR-mediated phosphorylation of Claspin
bound Chk1 during checkpoint signaling 181
Rüdiger Rudolf and
Paulo J. Magalhães and
Tullio Pozzan Direct in vivo monitoring of
sarcoplasmic reticulum Ca$^{2+}$ and
cytosolic cAMP dynamics in mouse
skeletal muscle . . . . . . . . . . . . 187
Simon Bekker-Jensen and
Claudia Lukas and
Risa Kitagawa and
Fredrik Melander and
Michael B. Kastan and
Jiri Bartek and
Jiri Lukas Spatial organization of the mammalian
genome surveillance machinery in
response to DNA strand breaks . . . . . 195
Xavier Darzacq and
Nupur Kittur and
Sujayita Roy and
Yaron Shav-Tal and
Robert H. Singer and
U. Thomas Meier Stepwise RNP assembly at the site of
H/ACA RNA transcription in human cells 207
David Frescas and
Manos Mavrakis and
Holger Lorenz and
Robert DeLotto and
Jennifer Lippincott-Schwartz The secretory membrane system in the
\bionameDrosophila syncytial blastoderm
embryo exists as functionally
compartmentalized units around
individual nuclei . . . . . . . . . . . 219
Marta Artal-Sanz and
Chrysanthi Samara and
Popi Syntichaki and
Nektarios Tavernarakis Lysosomal biogenesis and function is
critical for necrotic cell death in
\bionameCaenorhabditis elegans . . . . . 231
Malika Ahras and
Grant P. Otto and
Sharon A. Tooze Synaptotagmin IV is necessary for the
maturation of secretory granules in PC12
cells . . . . . . . . . . . . . . . . . 241
Mahalakshmi Nair and
Andy Teng and
Virginia Bilanchone and
Anshu Agrawal and
Baoan Li and
Xing Dai Ovol1 regulates the growth arrest of
embryonic epidermal progenitor cells and
represses c-myc transcription . . . . . 253
Tatsiana Tararuk and
Nina Östman and
Wenrui Li and
Benny Björkblom and
Artur Padzik and
Justyna Zdrojewska and
Vesa Hongisto and
Thomas Herdegen and
Witold Konopka and
Michael J. Courtney and
Eleanor T. Coffey JNK1 phosphorylation of SCG10 determines
microtubule dynamics and axodendritic
length . . . . . . . . . . . . . . . . . 265
Sheng-Li Cai and
Andrew R. Tee and
John D. Short and
Judith M. Bergeron and
Jinhee Kim and
Jianjun Shen and
Ruifeng Guo and
Charles L. Johnson and
Kaoru Kiguchi and
Cheryl Lyn Walker Activity of TSC2 is inhibited by
AKT-mediated phosphorylation and
membrane partitioning . . . . . . . . . 279
Pedro F. Esteban and
Hye-Young Yoon and
Jodi Becker and
Susan G. Dorsey and
Paola Caprari and
Mary Ellen Palko and
Vincenzo Coppola and
H. Uri Saragovi and
Paul A. Randazzo and
Lino Tessarollo A kinase-deficient TrkC receptor isoform
activates Arf6--Rac1 signaling through
the scaffold protein tamalin . . . . . . 291
Olga Sukocheva and
Carol Wadham and
Andrew Holmes and
Nathaniel Albanese and
Emily Verrier and
Feng Feng and
Alex Bernal and
Claudia K. Derian and
Axel Ullrich and
Mathew A. Vadas and
Pu Xia Estrogen transactivates EGFR via the
sphingosine $1$-phosphate receptor
Edg-3: the role of sphingosine kinase-1 301
Balaji Bandyopadhyay and
Jianhua Fan and
Shengxi Guan and
Yong Li and
Mei Chen and
David T. Woodley and
Wei Li Correction . . . . . . . . . . . . . . . 311
Rabiya S. Tuma Stress fibers from two sources . . . . . 314
Rabiya S. Tuma An axonal winch . . . . . . . . . . . . ??
Rabiya S. Tuma In-and-out signaling . . . . . . . . . . 315
Rabiya S. Tuma Assembling pores . . . . . . . . . . . . ??
Rabiya S. Tuma One cell, two chemotaxis systems . . . . ??
Nicole LeBrasseur Don't cut too soon . . . . . . . . . . . 316
Nicole LeBrasseur Putting mitosis in reverse . . . . . . . ??
Nicole LeBrasseur Neuronal corridors . . . . . . . . . . . 317
Nicole LeBrasseur Migrating interphase DNA . . . . . . . . ??
Nicole LeBrasseur Two ways for insertion . . . . . . . . . ??
Victor Fok and
Kyle Friend and
Joan A. Steitz Epstein-Barr virus noncoding RNAs are
confined to the nucleus, whereas their
partner, the human La protein, undergoes
nucleocytoplasmic shuttling . . . . . . 319
Boqian Wu and
Kim Ottow and
Peter Poulsen and
Richard F. Gaber and
Eva Albers and
Morten C. Kielland-Brandt Competitive intra- and extracellular
nutrient sensing by the transporter
homologue Ssy1p . . . . . . . . . . . . 327
Mariko Moriyama and
Masatake Osawa and
Siu-Shan Mak and
Toshiyuki Ohtsuka and
Norio Yamamoto and
Hua Han and
Véronique Delmas and
Ryoichiro Kageyama and
Friedrich Beermann and
Lionel Larue and
Shin-Ichi Nishikawa Notch signaling via Hes1 transcription
factor maintains survival of
melanoblasts and melanocyte stem cells 333
Reinhard Windoffer and
Anne Kölsch and
Stefan Wöll and
Rudolf E. Leube Focal adhesions are hotspots for keratin
filament precursor formation . . . . . . 341
Alice Lebreton and
Cosmin Saveanu and
Laurence Decourty and
Jean-Christophe Rain and
Alain Jacquier and
Micheline Fromont-Racine A functional network involved in the
recycling of nucleocytoplasmic pre-60S
factors . . . . . . . . . . . . . . . . 349
Alexis S. Madrid and
Joel Mancuso and
W. Zacheus Cande and
Karsten Weis The role of the integral membrane
nucleoporins Ndc1p and Pom152p in
nuclear pore complex assembly and
function . . . . . . . . . . . . . . . . 361
Kyle E. Miller and
Michael P. Sheetz Direct evidence for coherent low
velocity axonal transport of
mitochondria . . . . . . . . . . . . . . 373
Pirta Hotulainen and
Pekka Lappalainen Stress fibers are generated by two
distinct actin assembly mechanisms in
motile cells . . . . . . . . . . . . . . 383
Weigang Wang and
Ghassan Mouneimne and
Mazen Sidani and
Jeffrey Wyckoff and
Xiaoming Chen and
Anastasia Makris and
Sumanta Goswami and
Anne R. Bresnick and
John S. Condeelis The activity status of cofilin is
directly related to invasion,
intravasation, and metastasis of mammary
tumors . . . . . . . . . . . . . . . . . 395
Will Wood and
Celia Faria and
Antonio Jacinto Distinct mechanisms regulate hemocyte
chemotaxis during development and wound
healing in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 405
Rong Hou and
Liming Liu and
Syed Anees and
Shungo Hiroyasu and
Nicholas E. S. Sibinga The Fat1 cadherin integrates vascular
smooth muscle cell growth and migration
signals . . . . . . . . . . . . . . . . 417
Wendy F. Liu and
Celeste M. Nelson and
Dana M. Pirone and
Christopher S. Chen E-cadherin engagement stimulates
proliferation via Rac1 . . . . . . . . . 431
Elliott J. Hagedorn and
Jennifer L. Bayraktar and
Vasundhara R. Kandachar and
Ting Bai and
Dane M. Englert and
Henry C. Chang Drosophila melanogaster auxilin
regulates the internalization of Delta
to control activity of the Notch
signaling pathway . . . . . . . . . . . 443
Nicole LeBrasseur Hoarding bug . . . . . . . . . . . . . . 454
Nicole LeBrasseur DNA recruits nuclear envelope . . . . . ??
Nicole LeBrasseur Acetylate to kill or save . . . . . . . 455
Nicole LeBrasseur Milton for motile mitochondria . . . . . ??
Nicole LeBrasseur Titinless mice . . . . . . . . . . . . . ??
William A. Wells Lysosomes for lunch . . . . . . . . . . 456
William A. Wells Twisting endocytosis . . . . . . . . . . ??
William A. Wells Tracks for cellulose . . . . . . . . . . 457
William A. Wells Flow makes vein . . . . . . . . . . . . ??
William A. Wells Lamins as youth elixir . . . . . . . . . ??
Sarah E. Rice and
Vladimir I. Gelfand Paradigm lost: milton connects kinesin
heavy chain to miro on mitochondria . . 459
Susan M. Millard and
Stephen A. Wood Riding the DUBway: regulation of protein
trafficking by deubiquitylating enzymes 463
Sebastian Ulbert and
Melpomeni Platani and
Stephanie Boue and
Iain W. Mattaj Direct membrane protein--DNA
interactions required early in nuclear
envelope assembly . . . . . . . . . . . 469
Fabrizia Stavru and
Gitte Nautrup-Pedersen and
Volker C. Cordes and
Dirk Görlich Nuclear pore complex assembly and
maintenance in POM121- and
gp210-deficient cells . . . . . . . . . 477
Hong Wang and
Christer Höög Structural damage to meiotic chromosomes
impairs DNA recombination and checkpoint
control in mammalian oocytes . . . . . . 485
Fang Yang and
Rabindranath De La Fuente and
N. Adrian Leu and
Claudia Baumann and
K. John McLaughlin and
P. Jeremy Wang Mouse SYCP2 is required for synaptonemal
complex assembly and chromosomal
synapsis during male meiosis . . . . . . 497
Fabrizia Stavru and
Bastian B. Hülsmann and
Anne Spang and
Enno Hartmann and
Volker C. Cordes and
Dirk Görlich NDC1: a crucial membrane-integral
nucleoporin of metazoan nuclear pore
complexes . . . . . . . . . . . . . . . 509
Peter K. Kim and
Robert T. Mullen and
Uwe Schumann and
Jennifer Lippincott-Schwartz The origin and maintenance of mammalian
peroxisomes involves a de novo
PEX16-dependent pathway from the ER . . 521
Chad D. Knights and
Jason Catania and
Simone Di Giovanni and
Selen Muratoglu and
Ricardo Perez and
Amber Swartzbeck and
Andrew A. Quong and
Xiaojing Zhang and
Terry Beerman and
Richard G. Pestell and
Maria Laura Avantaggiati Distinct p53 acetylation cassettes
differentially influence gene-expression
patterns and cell fate . . . . . . . . . 533
Elizabeth E. Glater and
Laura J. Megeath and
R. Steven Stowers and
Thomas L. Schwarz Axonal transport of mitochondria
requires milton to recruit kinesin heavy
chain and is light chain independent . . 545
Stefanie Weinert and
Nora Bergmann and
Xiuju Luo and
Bettina Erdmann and
Michael Gotthardt M line--deficient titin causes cardiac
lethality through impaired maturation of
the sarcomere . . . . . . . . . . . . . 559
Shiro Suetsugu and
Shusaku Kurisu and
Tsukasa Oikawa and
Daisuke Yamazaki and
Atsushi Oda and
Tadaomi Takenawa Optimization of WAVE2 complex--induced
actin polymerization by membrane-bound
IRSp53, PIP$_3$, and Rac . . . . . . . . 571
Anjana Nayal and
Donna J. Webb and
Claire M. Brown and
Erik M. Schaefer and
Miguel Vicente-Manzanares and
Alan Rick Horwitz Paxillin phosphorylation at Ser273
localizes a GIT1--PIX--PAK complex and
regulates adhesion and protrusion
dynamics . . . . . . . . . . . . . . . . 587
Izumi Oinuma and
Hironori Katoh and
Manabu Negishi Semaphorin 4D/Plexin--B1-mediated R--Ras
GAP activity inhibits cell migration by
regulating $ \beta_1 $ integrin activity 601
Christopher Foote and
Steven F. Nothwehr The clathrin adaptor complex 1 directly
binds to a sorting signal in Ste13p to
reduce the rate of its trafficking to
the late endosome of yeast . . . . . . . 615
Nicolas Doulet and
Emmanuel Donnadieu and
Marie-Pierre Laran-Chich and
Florence Niedergang and
Xavier Nassif and
Pierre Olivier Couraud and
Sandrine Bourdoulous Neisseria meningitidis infection of
human endothelial cells interferes with
leukocyte transmigration by preventing
the formation of endothelial docking
structures . . . . . . . . . . . . . . . 627
Rabiya S. Tuma Reinforced microtubules . . . . . . . . 640
Rabiya S. Tuma An unused license to fire . . . . . . . ??
Rabiya S. Tuma Tunneling through cells . . . . . . . . 641
Rabiya S. Tuma Rab proteins move integrins . . . . . . ??
Rabiya S. Tuma It takes two to regulate . . . . . . . . ??
Alla Katsnelson B cells spread to affinity . . . . . . . 642
Alla Katsnelson Cell clusters follow the leaders . . . . ??
Alla Katsnelson Time out for neurons . . . . . . . . . . 643
Alla Katsnelson Genome punctuation . . . . . . . . . . . ??
Alla Katsnelson ES cells clean house . . . . . . . . . . ??
Mafalda Escobar-Henriques and
Benedikt Westermann and
Thomas Langer Regulation of mitochondrial fusion by
the F-box protein Mdm30 involves
proteasome-independent turnover of Fzo1 645
Hiromi Sesaki and
Cory D. Dunn and
Miho Iijima and
Kelly A. Shepard and
Michael P. Yaffe and
Carolyn E. Machamer and
Robert E. Jensen Ups1p, a conserved intermembrane space
protein, regulates mitochondrial shape
and alternative topogenesis of Mgm1p . . 651
Jeffrey D. Kearns and
Soumen Basak and
Shannon L. Werner and
Christine S. Huang and
Alexander Hoffmann I$ \kappa $B$ \epsilon $ provides
negative feedback to control NF-$ \kappa
$B oscillations, signaling dynamics, and
inflammatory gene expression . . . . . . 659
Yoshitaka Nakamori and
Masahiro Emoto and
Naofumi Fukuda and
Akihiko Taguchi and
Shigeru Okuya and
Michiko Tajiri and
Makoto Miyagishi and
Kazunari Taira and
Yoshinao Wada and
Yukio Tanizawa Myosin motor Myo1c and its receptor
NEMO/IKK-$ \gamma $ promote TNF-$ \alpha
$-induced serine$^{307}$ phosphorylation
of IRS-1 . . . . . . . . . . . . . . . . 665
Anna M. Woodward and
Thomas Göhler and
M. Gloria Luciani and
Maren Oehlmann and
Xinquan Ge and
Anton Gartner and
Dean A. Jackson and
J. Julian Blow Excess Mcm2--7 license dormant origins
of replication that can be used under
conditions of replicative stress . . . . 673
Lori L. O'Brien and
Christiane Wiese TPX2 is required for postmitotic nuclear
assembly in cell-free \bionameXenopus
laevis egg extracts . . . . . . . . . . 685
Mirta Boban and
Arezou Zargari and
Claes Andréasson and
Stijn Heessen and
Johan Thyberg and
Per O. Ljungdahl Asi1 is an inner nuclear membrane
protein that restricts promoter access
of two latent transcription factors . . 695
Shun-ichi Yamashita and
Masahide Oku and
Yuko Wasada and
Yoshitaka Ano and
Yasuyoshi Sakai PI4P-signaling pathway for the synthesis
of a nascent membrane structure in
selective autophagy . . . . . . . . . . 709
Derk Binns and
Tom Januszewski and
Yue Chen and
Justin Hill and
Vladislav S. Markin and
Yingming Zhao and
Christopher Gilpin and
Kent D. Chapman and
Richard G. W. Anderson and
Joel M. Goodman An intimate collaboration between
peroxisomes and lipid bodies . . . . . . 719
Clifford P. Brangwynne and
Frederick C. MacKintosh and
Sanjay Kumar and
Nicholas A. Geisse and
Jennifer Talbot and
L. Mahadevan and
Kevin K. Parker and
Donald E. Ingber and
David A. Weitz Microtubules can bear enhanced
compressive loads in living cells
because of lateral reinforcement . . . . 733
Ken-ichi Wakabayashi and
Stephen M. King Modulation of Chlamydomonas reinhardtii
flagellar motility by redox poise . . . 743
Toru Matsu-ura and
Takayuki Michikawa and
Takafumi Inoue and
Atsushi Miyawaki and
Manabu Yoshida and
Katsuhiko Mikoshiba Cytosolic inositol 1,4,5-trisphosphate
dynamics during intracellular calcium
oscillations in living cells . . . . . . 755
Teijo Pellinen and
Antti Arjonen and
Karoliina Vuoriluoto and
Katja Kallio and
Jack A. M. Fransen and
Johanna Ivaska Small GTPase Rab21 regulates cell
adhesion and controls endosomal traffic
of $ \beta $1-integrins . . . . . . . . 767
Nasreen Akhtar and
Charles H. Streuli Rac1 links integrin-mediated adhesion to
the control of lactational
differentiation in mammary epithelia . . 781
Sascha Nydegger and
Sandhya Khurana and
Dimitry N. Krementsov and
Michelangelo Foti and
Markus Thali Mapping of tetraspanin-enriched
microdomains that can function as
gateways for HIV-1 . . . . . . . . . . . 795
Laurent Boyer and
Anne Doye and
Monica Rolando and
Gilles Flatau and
Patrick Munro and
Pierre Gounon and
René Clément and
Céline Pulcini and
Michel R. Popoff and
Amel Mettouchi and
Luce Landraud and
Olivier Dussurget and
Emmanuel Lemichez Induction of transient macroapertures in
endothelial cells through RhoA
inhibition by Staphylococcus aureus
factors . . . . . . . . . . . . . . . . 809
Tatsiana Tararuk and
Nina Östman and
Wenrui Li and
Benny Björkblom and
Artur Padzik and
Justyna Zdrojewska and
Vesa Hongisto and
Thomas Herdegen and
Witold Konopka and
Michael J. Courtney and
Eleanor T. Coffey Correction 173, p. 265 . . . . . . . . . 821
William A. Wells Pilings in a lipid sea . . . . . . . . . 824
William A. Wells SPB building blocks . . . . . . . . . . ??
William A. Wells Muscular measuring stick . . . . . . . . 825
William A. Wells Transcriptional glue . . . . . . . . . . ??
William A. Wells Biased spindle formation . . . . . . . . ??
Nicole LeBrasseur Disorder for variety . . . . . . . . . . 826
Nicole LeBrasseur Cage folding . . . . . . . . . . . . . . ??
Nicole LeBrasseur Genes pulse with activity . . . . . . . 827
Nicole LeBrasseur Virus squeezed shut . . . . . . . . . . ??
Nicole LeBrasseur Signaling from keratins . . . . . . . . ??
Andrew Wilde ``HURP on'' we're off to the
kinetochore! . . . . . . . . . . . . . . 829
Gerben Vader and
René H. Medema and
Susanne M. A. Lens The chromosomal passenger complex:
guiding Aurora--B through mitosis . . . 833
Zakaria A. Almsherqi and
Sepp D. Kohlwein and
Yuru Deng Cubic membranes: a legend beyond the
Flatland* of cell membrane organization 839
Xie Tang and
Ye Jin and
W. Zacheus Cande Bqt2p is essential for initiating
telomere clustering upon pheromone
sensing in fission yeast . . . . . . . . 845
Michele L. Forster and
Kelsey Sivick and
Young-nam Park and
Peter Arvan and
Wayne I. Lencer and
Billy Tsai Protein disulfide isomerase-like
proteins play opposing roles during
retrotranslocation . . . . . . . . . . . 853
Tomasz J. Proszynski and
Robin Klemm and
Michel Bagnat and
Katharina Gaus and
Kai Simons Plasma membrane polarization during
mating in yeast cells . . . . . . . . . 861
Sam Li and
Alan M. Sandercock and
Paul Conduit and
Carol V. Robinson and
Roger L. Williams and
John V. Kilmartin Structural role of Sfi1p--centrin
filaments in budding yeast spindle pole
body duplication . . . . . . . . . . . . 867
Jim Wong and
Guowei Fang HURP controls spindle dynamics to
promote proper interkinetochore tension
and efficient kinetochore capture . . . 879
Felix Machín and
Jordi Torres-Rosell and
Giacomo De Piccoli and
Jesús A. Carballo and
Rita S. Cha and
Adam Jarmuz and
Luis Aragón Transcription of ribosomal genes can
cause nondisjunction . . . . . . . . . . 893
Marie-Louise Bang and
Xiaodong Li and
Ryan Littlefield and
Shannon Bremner and
Andrea Thor and
Kirk U. Knowlton and
Richard L. Lieber and
Ju Chen Nebulin-deficient mice exhibit shorter
thin filament lengths and reduced
contractile function in skeletal muscle 905
Dikran Aivazian and
Ramon L. Serrano and
Suzanne Pfeffer TIP47 is a key effector for Rab9
localization . . . . . . . . . . . . . . 917
Lindsay N. Carpp and
Leonora F. Ciufo and
Scott G. Shanks and
Alan Boyd and
Nia J. Bryant The Sec1p/Munc18 protein Vps45p binds
its cognate SNARE proteins via two
distinct modes . . . . . . . . . . . . . 927
Nikunj Sharma and
Seng Hui Low and
Saurav Misra and
Bhattaram Pallavi and
Thomas Weimbs Apical targeting of syntaxin 3 is
essential for epithelial cell polarity 937
Samuel Liégeois and
Alexandre Benedetto and
Jean-Marie Garnier and
Yannick Schwab and
Michel Labouesse The V0-ATPase mediates apical secretion
of exosomes containing Hedgehog-related
proteins in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 949
Krista M. Hennig and
Julien Colombani and
Thomas P. Neufeld TOR coordinates bulk and targeted
endocytosis in the \bionameDrosophila
melanogaster fat body to regulate cell
growth . . . . . . . . . . . . . . . . . 963
Guangwei Min and
Huaibin Wang and
Tung-Tien Sun and
Xiang-Peng Kong Structural basis for tetraspanin
functions as revealed by the cryo--EM
structure of uroplakin complexes at 6-Å
resolution . . . . . . . . . . . . . . . 975
Sara K. Olson and
Joseph R. Bishop and
John R. Yates and
Karen Oegema and
Jeffrey D. Esko Identification of novel chondroitin
proteoglycans in \bionameCaenorhabditis
elegans: embryonic cell division depends
on CPG-1 and CPG-2 . . . . . . . . . . . 985
Rabiya S. Tuma Chromatin zigzags . . . . . . . . . . . 2
Rabiya S. Tuma Opposites attract . . . . . . . . . . . ??
Rabiya S. Tuma Soaking up stress . . . . . . . . . . . 3
Rabiya S. Tuma Death by Cdc6 . . . . . . . . . . . . . ??
Rabiya S. Tuma Microclustered signaling . . . . . . . . ??
Nicole LeBrasseur Sights on cone geometry . . . . . . . . 4
Nicole LeBrasseur Alien sensing by GC content . . . . . . ??
Nicole LeBrasseur Entropy guards pore . . . . . . . . . . 5
Nicole LeBrasseur Phosphate give and take . . . . . . . . ??
Nicole LeBrasseur Axon's vesicles in excess . . . . . . . ??
Gerard M. J. Beaudoin Con-nectin axons and dendrites . . . . . 7
Vladimir I. Titorenko and
Robert T. Mullen Peroxisome biogenesis: the peroxisomal
endomembrane system and the role of the
ER . . . . . . . . . . . . . . . . . . . 11
Karen K. Y. Lam and
Michael Davey and
Beimeng Sun and
Amy F. Roth and
Nicholas G. Davis and
Elizabeth Conibear Palmitoylation by the DHHC protein Pfa4
regulates the ER exit of Chs3 . . . . . 19
Lindsay S. Shopland and
Christopher R. Lynch and
Kevin A. Peterson and
Kathleen Thornton and
Nick Kepper and
Johann von Hase and
Stefan Stein and
Sarah Vincent and
Kelly R. Molloy and
Gregor Kreth and
Christoph Cremer and
Carol J. Bult and
Timothy P. O'Brien Folding and organization of a contiguous
chromosome region according to the gene
distribution pattern in primary genomic
sequence . . . . . . . . . . . . . . . . 27
Luigi Nezi and
Giulia Rancati and
Anna De Antoni and
Sebastiano Pasqualato and
Simonetta Piatti and
Andrea Musacchio Accumulation of Mad2--Cdc20 complex
during spindle checkpoint activation
requires binding of open and closed
conformers of Mad2 in
\bionameSaccharomyces cerevisiae . . . . 39
Yusong Guo and
Adam D. Linstedt COPII--Golgi protein interactions
regulate COPII coat assembly and Golgi
size . . . . . . . . . . . . . . . . . . 53
Alexandre Janer and
Elodie Martin and
Marie-Paule Muriel and
Morwena Latouche and
Hiroto Fujigasaki and
Merle Ruberg and
Alexis Brice and
Yvon Trottier and
Annie Sittler PML clastosomes prevent nuclear
accumulation of mutant ataxin-7 and
other polyglutamine proteins . . . . . . 65
Hyungshin Yim and
In Sun Hwang and
Joon-Seok Choi and
Kwang-Hoon Chun and
Ying Hua Jin and
Young-Mi Ham and
Kwang Youl Lee and
Seung Ki Lee Cleavage of Cdc6 by caspase-3 promotes
ATM/ATR kinase-mediated apoptosis of
HeLa cells . . . . . . . . . . . . . . . 77
Chris Allen and
Sabrina Büttner and
Anthony D. Aragon and
Jason A. Thomas and
Osorio Meirelles and
Jason E. Jaetao and
Don Benn and
Stephanie W. Ruby and
Marten Veenhuis and
Frank Madeo and
Margaret Werner-Washburne Isolation of quiescent and nonquiescent
cells from yeast stationary-phase
cultures . . . . . . . . . . . . . . . . 89
Lisa M. Hoffman and
Kamal Garcha and
Konstantina Karamboulas and
Matthew F. Cowan and
Linsay M. Drysdale and
William A. Horton and
T. Michael Underhill BMP action in skeletogenesis involves
attenuation of retinoid signaling . . . 101
Nam-On Ku and
M. Bishr Omary A disease- and phosphorylation-related
nonmechanical function for keratin 8 . . 115
Azlina Ahmad-Annuar and
Lorenza Ciani and
Iordanis Simeonidis and
Judit Herreros and
Naila Ben Fredj and
Silvana B. Rosso and
Anita Hall and
Stephen Brickley and
Patricia C. Salinas Signaling across the synapse: a role for
Wnt and Dishevelled in presynaptic
assembly and neurotransmitter release 127
Hideru Togashi and
Jun Miyoshi and
Tomoyuki Honda and
Toshiaki Sakisaka and
Yoshimi Takai and
Masatoshi Takeichi Interneurite affinity is regulated by
heterophilic nectin interactions in
concert with the cadherin machinery . . 141
Bebhinn Treanor and
Peter M. P. Lanigan and
Sunil Kumar and
Chris Dunsby and
Ian Munro and
Egidijus Auksorius and
Fiona J. Culley and
Marco A. Purbhoo and
David Phillips and
Mark A. A. Neil and
Deborah N. Burshtyn and
Paul M. W. French and
Daniel M. Davis Microclusters of inhibitory killer
immunoglobulin-like receptor signaling
at natural killer cell immunological
synapses . . . . . . . . . . . . . . . . 153
Rabiya S. Tuma Homing therapy . . . . . . . . . . . . . 164
Rabiya S. Tuma Scattering synaptic vesicles . . . . . . ??
Rabiya S. Tuma Actin senses self-incompatibility . . . 165
Rabiya S. Tuma Funky FAK proliferation . . . . . . . . ??
Rabiya S. Tuma Linking secretion and cell cycle . . . . ??
William A. Wells How HIV-1 lost control . . . . . . . . . 166
William A. Wells Slow escape from mitosis . . . . . . . . ??
William A. Wells Flexible tumor metabolism . . . . . . . 167
William A. Wells Seeing tube formation . . . . . . . . . ??
William A. Wells Mixed kinetochore fiber . . . . . . . . ??
Jürgen Schweizer and
Paul E. Bowden and
Pierre A. Coulombe and
Lutz Langbein and
E. Birgitte Lane and
Thomas M. Magin and
Lois Maltais and
M. Bishr Omary and
David A. D. Parry and
Michael A. Rogers and
Mathew W. Wright New consensus nomenclature for mammalian
keratins . . . . . . . . . . . . . . . . 169
Sylvie Thuault and
Ulrich Valcourt and
Maj Petersen and
Guidalberto Manfioletti and
Carl-Henrik Heldin and
Aristidis Moustakas Transforming growth factor-$ \beta $
employs HMGA2 to elicit
epithelial--mesenchymal transition . . . 175
Rong Wu and
Prim B. Singh and
David M. Gilbert Uncoupling global and fine-tuning
replication timing determinants for
mouse pericentric heterochromatin . . . 185
Michael Blank and
Yaniv Lerenthal and
Leonid Mittelman and
Yosef Shiloh Condensin I recruitment and uneven
chromatin condensation precede mitotic
cell death in response to DNA damage . . 195
Gang Zhang and
Rohini Kashimshetty and
Kwee Eng Ng and
Heng Buck Tan and
Foong May Yeong Exit from mitosis triggers Chs2p
transport from the endoplasmic reticulum
to mother--daughter neck via the
secretory pathway in budding yeast . . . 207
Steven G. Thomas and
Shanjin Huang and
Shutian Li and
Christopher J. Staiger and
Vernonica E. Franklin-Tong Actin depolymerization is sufficient to
induce programmed cell death in
self-incompatible pollen . . . . . . . . 221
Beatriz G. Galvez and
Maurilio Sampaolesi and
Silvia Brunelli and
Diego Covarello and
Manuela Gavina and
Barbara Rossi and
Gabriela Constantin and
Yvan Torrente and
Giulio Cossu Complete repair of dystrophic skeletal
muscle by mesoangioblasts with enhanced
migration ability . . . . . . . . . . . 231
Yosuke Nagata and
Terence A. Partridge and
Ryoichi Matsuda and
Peter S. Zammit Entry of muscle satellite cells into the
cell cycle requires sphingolipid
signaling . . . . . . . . . . . . . . . 245
Elaine F. Corbett-Nelson and
David Mason and
John G. Marshall and
Yves Collette and
Sergio Grinstein Signaling-dependent immobilization of
acylated proteins in the inner monolayer
of the plasma membrane . . . . . . . . . 255
Nick De Regge and
Hans J. Nauwynck and
Kristin Geenen and
Claude Krummenacher and
Gary H. Cohen and
Roselyn J. Eisenberg and
Thomas C. Mettenleiter and
Herman W. Favoreel $ \alpha $-Herpesvirus glycoprotein D
interaction with sensory neurons
triggers formation of varicosities that
serve as virus exit sites . . . . . . . 267
Dana M. Pirone and
Wendy F. Liu and
Sami Alom Ruiz and
Lin Gao and
Srivatsan Raghavan and
Christopher A. Lemmon and
Lewis H. Romer and
Christopher S. Chen An inhibitory role for FAK in regulating
proliferation: a link between limited
adhesion and RhoA--ROCK signaling . . . 277
Shernaz X. Bamji and
Beatriz Rico and
Nikole Kimes and
Louis F. Reichardt BDNF mobilizes synaptic vesicles and
enhances synapse formation by disrupting
cadherin--$ \beta $-catenin interactions 289
Xuejun Chen and
Barry M. Gumbiner Paraxial protocadherin mediates cell
sorting and tissue morphogenesis by
regulating C-cadherin adhesion activity 301
Soo Jin Chun and
Matthew N. Rasband and
Richard L. Sidman and
Amyn A. Habib and
Timothy Vartanian Correction 163, p. 397 . . . . . . . . . 315
Rabiya S. Tuma Sitting in --- not through --- a
membrane . . . . . . . . . . . . . . . . 318
Rabiya S. Tuma Cell front supports the back . . . . . . ??
Rabiya S. Tuma Mannose receptor regulates motility . . 319
Rabiya S. Tuma Early transcription . . . . . . . . . . ??
Rabiya S. Tuma Contractile ring formation . . . . . . . ??
Ruth Williams Salmonella sneaks past security . . . . 320
Ruth Williams Transforming antibiotic treatment . . . ??
Ruth Williams Nucleotides: saviors of the cell . . . . 321
Ruth Williams Positioning proteasomes . . . . . . . . ??
Ruth Williams The fragility factor . . . . . . . . . . ??
Johan Kreuger and
Dorothe Spillmann and
Jin-ping Li and
Ulf Lindahl Interactions between heparan sulfate and
proteins: the concept of specificity . . 323
Maria Elena Torres-Padilla and
Magdalena Zernicka-Goetz Role of TIF1$ \alpha $ as a modulator of
embryonic transcription in the mouse
zygote . . . . . . . . . . . . . . . . . 329
Troy Camarata and
Benjamin Bimber and
Andre Kulisz and
Teng-Leong Chew and
Jennifer Yeung and
Hans-Georg Simon LMP4 regulates Tbx5 protein subcellular
localization and activity . . . . . . . 339
Mary D. Schneider and
Nima Najand and
Sana Chaker and
Justin M. Pare and
Julie Haskins and
Sarah C. Hughes and
Tom C. Hobman and
John Locke and
Andrew J. Simmonds Gawky is a component of cytoplasmic mRNA
processing bodies required for early
\bionameDrosophila development . . . . . 349
Sidney Yu and
Ayano Satoh and
Marc Pypaert and
Karl Mullen and
Jesse C. Hay and
Susan Ferro-Novick mBet3p is required for homotypic COPII
vesicle tethering in mammalian cells . . 359
Carlos Fernández-Hernando and
Masaki Fukata and
Pascal N. Bernatchez and
Yuko Fukata and
Michelle I. Lin and
David S. Bredt and
William C. Sessa Identification of Golgi-localized acyl
transferases that palmitoylate and
regulate endothelial nitric oxide
synthase . . . . . . . . . . . . . . . . 369
Steven M. Claypool and
J. Michael McCaffery and
Carla M. Koehler Mitochondrial mislocalization and
altered assembly of a cluster of Barth
syndrome mutant tafazzins . . . . . . . 379
Jian-Qiu Wu and
Vladimir Sirotkin and
David R. Kovar and
Matthew Lord and
Christopher C. Beltzner and
Jeffrey R. Kuhn and
Thomas D. Pollard Assembly of the cytokinetic contractile
ring from a broad band of nodes in
fission yeast . . . . . . . . . . . . . 391
Katie M. Jansen and
Grace K. Pavlath Mannose receptor regulates myoblast
motility and muscle growth . . . . . . . 403
Dong Yan and
Li Guo and
Yizheng Wang Requirement of dendritic Akt degradation
by the ubiquitin--proteasome system for
neuronal polarity . . . . . . . . . . . 415
Kaori Horiguchi and
Toshihiko Hanada and
Yasuhisa Fukui and
Athar H. Chishti Transport of PIP$_3$ by GAKIN, a
kinesin-3 family protein, regulates
neuronal cell polarity . . . . . . . . . 425
Alexandra Van Keymeulen and
Kit Wong and
Zachary A. Knight and
Cedric Govaerts and
Klaus M. Hahn and
Kevan M. Shokat and
Henry R. Bourne To stabilize neutrophil polarity, PIP3
and Cdc42 augment RhoA activity at the
back as well as signals at the front . . 437
Norio Takizawa and
Tara C. Smith and
Thomas Nebl and
Jessica L. Crowley and
Stephen J. Palmieri and
Lawrence M. Lifshitz and
Anka G. Ehrhardt and
Laura M. Hoffman and
Mary C. Beckerle and
Elizabeth J. Luna Supervillin modulation of focal
adhesions involving TRIP6/ZRP-1 . . . . 447
Katrin Deinhardt and
Otto Berninghausen and
Hugh J. Willison and
Colin R. Hopkins and
Giampietro Schiavo Tetanus toxin is internalized by a
sequential clathrin-dependent mechanism
initiated within lipid microdomains and
independent of epsin1 . . . . . . . . . 459
Nicole LeBrasseur PKC decodes Ca$^{2+}$ . . . . . . . . . 474
Nicole LeBrasseur Integrins for mitosis . . . . . . . . . ??
Nicole LeBrasseur Cohesin loops DNA . . . . . . . . . . . 475
Nicole LeBrasseur Cadherin stops receptor endocytosis . . ??
William A. Wells How chronic stress exacerbates cancer 476
William A. Wells Charged signaling . . . . . . . . . . . ??
William A. Wells Electric healing . . . . . . . . . . . . 477
William A. Wells Relaxing after damage . . . . . . . . . ??
William A. Wells Making a single centrosome . . . . . . . ??
Nicole LeBrasseur The Nuclear Family: Functional
Organization of the Cell Nucleus Prague,
Czech Republic, May 5--8, 2006 . . . . . 478
Yu-li Wang and
Klaus M. Hahn and
Robert F. Murphy and
Alan F. Horwitz From imaging to understanding: Frontiers
in Live Cell Imaging, Bethesda, MD,
April 19--21, 2006 . . . . . . . . . . . 481
Chris Janetopoulos and
Peter Devreotes Phosphoinositide signaling plays a key
role in cytokinesis . . . . . . . . . . 485
Carlos G. Reverte and
Angela Benware and
Christopher W. Jones and
Susan E. LaFlamme Perturbing integrin function inhibits
microtubule growth from centrosomes,
spindle assembly, and cytokinesis . . . 491
Da-Qiao Ding and
Nobuko Sakurai and
Yuki Katou and
Takehiko Itoh and
Katsuhiko Shirahige and
Tokuko Haraguchi and
Yasushi Hiraoka Meiotic cohesins modulate chromosome
compaction during meiotic prophase in
fission yeast . . . . . . . . . . . . . 499
Julian Pardo and
Christin Urban and
Eva M. Galvez and
Paul G. Ekert and
Uwe Müller and
June Kwon-Chung and
Mario Lobigs and
Arno Müllbacher and
Reinhard Wallich and
Christoph Borner and
Markus M. Simon The mitochondrial protein Bak is pivotal
for gliotoxin-induced apoptosis and a
critical host factor of Aspergillus
fumigatus virulence in mice . . . . . . 509
Gregor Reither and
Michael Schaefer and
Peter Lipp PKC$ \alpha $: a versatile key for
decoding the cellular calcium toolkit 521
Fabien Vanden Abeele and
Gabriel Bidaux and
Dmitri Gordienko and
Benjamin Beck and
Yuri V. Panchin and
Ancha V. Baranova and
Dmitry V. Ivanov and
Roman Skryma and
Natalia Prevarskaya Functional implications of calcium
permeability of the channel formed by
pannexin 1 . . . . . . . . . . . . . . . 535
Andreas W. Jehle and
Shyra J. Gardai and
Suzhao Li and
Patrick Linsel-Nitschke and
Konosuke Morimoto and
William J. Janssen and
R. William Vandivier and
Nan Wang and
Steven Greenberg and
Benjamin M. Dale and
Chunbo Qin and
Peter M. Henson and
Alan R. Tall ATP-binding cassette transporter A7
enhances phagocytosis of apoptotic cells
and associated ERK signaling in
macrophages . . . . . . . . . . . . . . 547
Selma Osmanagic-Myers and
Martin Gregor and
Gernot Walko and
Gerald Burgstaller and
Siegfried Reipert and
Gerhard Wiche Plectin-controlled keratin
cytoarchitecture affects MAP kinases
involved in cellular stress response and
migration . . . . . . . . . . . . . . . 557
Anni Hienola and
Sarka Tumova and
Evgeny Kulesskiy and
Heikki Rauvala N-syndecan deficiency impairs neural
migration in brain . . . . . . . . . . . 569
Sander H. Diks and
Robert J. Bink and
Sandra van de Water and
Jos Joore and
Carina van Rooijen and
Fons J. Verbeek and
Jeroen den Hertog and
Maikel P. Peppelenbosch and
Danica Zivkovic The novel gene asb11: a regulator of the
size of the neural progenitor
compartment . . . . . . . . . . . . . . 581
Maria Grazia Lampugnani and
Fabrizio Orsenigo and
Maria Cristina Gagliani and
Carlo Tacchetti and
Elisabetta Dejana Vascular endothelial cadherin controls
VEGFR-2 internalization and signaling
from intracellular compartments . . . . 593
Beatriz G. Galvez and
Maurilio Sampaolesi and
Silvia Brunelli and
Diego Covarello and
Manuela Gavina and
Barbara Rossi and
Gabriela Costantin and
Yvan Torrente and
Giulio Cossu Correction 174, p. 231 . . . . . . . . . 605
Rabiya S. Tuma miRNAs halt cell cycle . . . . . . . . . 608
Rabiya S. Tuma Formin localization . . . . . . . . . . ??
Rabiya S. Tuma Aged muscle lacks sparks . . . . . . . . 609
Rabiya S. Tuma Activating Rac . . . . . . . . . . . . . ??
Rabiya S. Tuma Ordered adhesions . . . . . . . . . . . ??
William A. Wells Malaria undercover . . . . . . . . . . . 610
William A. Wells Smell genes must wander . . . . . . . . ??
William A. Wells Segregation by entropy . . . . . . . . . 611
William A. Wells Killers aid a pregnancy . . . . . . . . ??
William A. Wells Automatic cell topology . . . . . . . . ??
Werner Melzer When sparks get old . . . . . . . . . . 613
Lance S. Terada Specificity in reactive oxidant
signaling: think globally, act locally 615
Vlastimil Srsen and
Nicole Gnadt and
Alexander Dammermann and
Andreas Merdes Inhibition of centrosome protein
assembly leads to p53-dependent exit
from the cell cycle . . . . . . . . . . 625
Yasushi Tamura and
Yoshihiro Harada and
Koji Yamano and
Kazuaki Watanabe and
Daigo Ishikawa and
Chié Ohshima and
Shuh-ichi Nishikawa and
Hayashi Yamamoto and
Toshiya Endo Identification of Tam41 maintaining
integrity of the TIM23 protein
translocator complex in mitochondria . . 631
Noah Weisleder and
Marco Brotto and
Shinji Komazaki and
Zui Pan and
Xiaoli Zhao and
Thomas Nosek and
Jerome Parness and
Hiroshi Takeshima and
Jianjie Ma Muscle aging is associated with
compromised Ca$^{2+}$ spark signaling
and segregated intracellular Ca$^{2+}$
release . . . . . . . . . . . . . . . . 639
Yuya Kunisaki and
Akihiko Nishikimi and
Yoshihiko Tanaka and
Ryosuke Takii and
Mayuko Noda and
Ayumi Inayoshi and
Ken-ichi Watanabe and
Fumiyuki Sanematsu and
Takehiko Sasazuki and
Takehiko Sasaki and
Yoshinori Fukui DOCK2 is a Rac activator that regulates
motility and polarity during neutrophil
chemotaxis . . . . . . . . . . . . . . . 647
Ben Montpetit and
Tony R. Hazbun and
Stanley Fields and
Philip Hieter Sumoylation of the budding yeast
kinetochore protein Ndc10 is required
for Ndc10 spindle localization and
regulation of anaphase spindle
elongation . . . . . . . . . . . . . . . 653
Sue L. Jaspersen and
Adriana E. Martin and
Galina Glazko and
Thomas H. Giddings and
Garry Morgan and
Arcady Mushegian and
Mark Winey The Sad1-UNC-84 homology domain in Mps3
interacts with Mps2 to connect the
spindle pole body with the nuclear
envelope . . . . . . . . . . . . . . . . 665
Hak Kyun Kim and
Yong Sun Lee and
Umasundari Sivaprasad and
Ankit Malhotra and
Anindya Dutta Muscle-specific microRNA miR-206
promotes muscle differentiation . . . . 677
Jiahu Wang and
Ningning Wang and
Jinling Xie and
Staci C. Walton and
Robert L. McKown and
Ronald W. Raab and
Peisong Ma and
Shannon L. Beck and
George L. Coffman and
Isa M. Hussaini and
Gordon W. Laurie Restricted epithelial proliferation by
lacritin via PKC$ \alpha $-dependent
NFAT and mTOR pathways . . . . . . . . . 689
Abhinav Seth and
Chinatsu Otomo and
Michael K. Rosen Autoinhibition regulates cellular
localization and actin assembly activity
of the diaphanous-related formins FRL$
\alpha $ and mDia1 . . . . . . . . . . . 701
Sandra Angelini and
Diana Boy and
Emile Schiltz and
Hans-Georg Koch Membrane binding of the bacterial signal
recognition particle receptor involves
two distinct binding sites . . . . . . . 715
Katharina Gaus and
Soazig Le Lay and
Nagaraj Balasubramanian and
Martin A. Schwartz Integrin-mediated adhesion regulates
membrane order . . . . . . . . . . . . . 725
Nicole LeBrasseur STIMulating Ca$^{2+}$ influx . . . . . . 736
Nicole LeBrasseur Cell cycle regulators kick out
centrosomes . . . . . . . . . . . . . . ??
Nicole LeBrasseur Hidden particles . . . . . . . . . . . . 737
Nicole LeBrasseur Sizing up actin fences . . . . . . . . . ??
Nicole LeBrasseur Stealing histones . . . . . . . . . . . ??
Ruth Williams Handy tool for high-resolution
microscopy . . . . . . . . . . . . . . . 738
Ruth Williams An open or closed case for HMGA . . . . 739
Ruth Williams Microtubule munching . . . . . . . . . . ??
Ruth Williams Live long and cancer-free . . . . . . . ??
William A. Wells Unpleasant surprises: how the
Introduction has wandered into the
Discussion . . . . . . . . . . . . . . . 741
Mitch Leslie The action behind the words: embryonic
stem cell research marches on . . . . . 743
Harmit S. Malik A hitchhiker's guide to survival finally
makes CENs . . . . . . . . . . . . . . . 747
Dae Young Kim and
Richard Roy Cell cycle regulators control centrosome
elimination during oogenesis in
\bionameCaenorhabditis elegans . . . . . 751
Boyan K. Garvalov and
Beno\^\it Zuber and
Cédric Bouchet-Marquis and
Mikhail Kudryashev and
Manuela Gruska and
Martin Beck and
Andrew Leis and
Friedrich Frischknecht and
Frank Bradke and
Wolfgang Baumeister and
Jacques Dubochet and
Marek Cyrklaff Luminal particles within cellular
microtubules . . . . . . . . . . . . . . 759
Marcus Prass and
Ken Jacobson and
Alex Mogilner and
Manfred Radmacher Direct measurement of the lamellipodial
protrusive force in a migrating cell . . 767
Keisuke Kamimura and
Takashi Koyama and
Hiroko Habuchi and
Ryu Ueda and
Masayuki Masu and
Koji Kimata and
Hiroshi Nakato Specific and flexible roles of heparan
sulfate modifications in
\bionameDrosophila FGF signaling . . . . 773
Sujata Hajra and
Santanu Kumar Ghosh and
Makkuni Jayaram The centromere-specific histone variant
Cse4p (CENP--A) is essential for
functional chromatin architecture at the
yeast 2-$ \mu $ m circle partitioning
locus and promotes equal plasmid
segregation . . . . . . . . . . . . . . 779
Suzanne Madgwick and
David V. Hansen and
Mark Levasseur and
Peter K. Jackson and
Keith T. Jones Mouse Emi2 is required to enter meiosis
II by reestablishing cyclin B1 during
interkinesis . . . . . . . . . . . . . . 791
Minnie M. Wu and
JoAnn Buchanan and
Riina M. Luik and
Richard S. Lewis Ca$^{2+}$ store depletion causes STIM1
to accumulate in ER regions closely
associated with the plasma membrane . . 803
Riina M. Luik and
Minnie M. Wu and
JoAnn Buchanan and
Richard S. Lewis The elementary unit of store-operated
Ca$^{2+}$ entry: local activation of
CRAC channels by STIM1 at ER--plasma
membrane junctions . . . . . . . . . . . 815
Jin-A Lee and
Sue-Hyun Lee and
Changhoon Lee and
Deok-Jin Chang and
Yong Lee and
Hyoung Kim and
Ye-Hwang Cheang and
Hyoung-Gon Ko and
Yong-Seok Lee and
Heejung Jun and
Dusan Bartsch and
Eric R. Kandel and
Bong-Kiun Kaang PKA-activated ApAF-ApC/EBP heterodimer
is a key downstream effector of ApCREB
and is necessary and sufficient for the
consolidation of long-term facilitation 827
Leticia Peris and
Manuel Thery and
Julien Fauré and
Yasmina Saoudi and
Laurence Lafanech\`ere and
John K. Chilton and
Phillip Gordon-Weeks and
Niels Galjart and
Michel Bornens and
Linda Wordeman and
Juergen Wehland and
Annie Andrieux and
Didier Job Tubulin tyrosination is a major factor
affecting the recruitment of CAP--Gly
proteins at microtubule plus ends . . . 839
Nobuhiro Morone and
Takahiro Fujiwara and
Kotono Murase and
Rinshi S. Kasai and
Hiroshi Ike and
Shigeki Yuasa and
Jiro Usukura and
Akihiro Kusumi Three-dimensional reconstruction of the
membrane skeleton at the plasma membrane
interface by electron tomography . . . . 851
Danijela Vignjevic and
Shin-ichiro Kojima and
Yvonne Aratyn and
Oana Danciu and
Tatyana Svitkina and
Gary G. Borisy Role of fascin in filopodial protrusion 863
Lawrence E. Goldfinger and
Celeste Ptak and
Erin D. Jeffery and
Jeffrey Shabanowitz and
Donald F. Hunt and
Mark H. Ginsberg RLIP76 (RalBP1) is an R--Ras effector
that mediates adhesion-dependent Rac
activation and cell migration . . . . . 877
Aleksandra Czuchra and
Hannelore Meyer and
Kyle R. Legate and
Cord Brakebusch and
Reinhard Fässler Genetic analysis of $ \beta $1 integrin
``activation motifs'' in mice . . . . . 889
William A. Wells Correction 174, p. 477 . . . . . . . . . 901
Yu-li Wang and
Klaus M. Hahn and
Robert F. Murphy and
Alan F. Horwitz Correction 174, p. 481 . . . . . . . . . 903
Rabiya S. Tuma Cooperative motors . . . . . . . . . . . 906
Rabiya S. Tuma There's a catch . . . . . . . . . . . . ??
Rabiya S. Tuma Spaced just right . . . . . . . . . . . 907
Rabiya S. Tuma Speeding nuclear import . . . . . . . . ??
Rabiya S. Tuma Trimming ERAD . . . . . . . . . . . . . ??
Nicole LeBrasseur A transcriptional black hole . . . . . . 908
Nicole LeBrasseur Malignancy from cooperation . . . . . . ??
Nicole LeBrasseur A myosin for RNA Pol II . . . . . . . . 909
Nicole LeBrasseur T cells told to keep rolling . . . . . . ??
Nicole LeBrasseur Stomata fight infection . . . . . . . . ??
Wendy Thomas For catch bonds, it all hinges on the
interdomain region . . . . . . . . . . . 911
György Csordás and
Christian Renken and
Péter Várnai and
Ludivine Walter and
David Weaver and
Karolyn F. Buttle and
Tamás Balla and
Carmen A. Mannella and
György Hajnóczky Structural and functional features and
significance of the physical linkage
between ER and mitochondria . . . . . . 915
Esteban A. Roberts and
Jennifer Chua and
George B. Kyei and
Vojo Deretic Higher order Rab programming in
phagolysosome biogenesis . . . . . . . . 923
Miki Imanishi and
Nicholas F. Endres and
Arne Gennerich and
Ronald D. Vale Autoinhibition regulates the motility of
the \bionameC. elegans intraflagellar
transport motor OSM-3 . . . . . . . . . 931
Debaditya Mukhopadhyay and
Ferhan Ayaydin and
Nagamalleswari Kolli and
Shyh-Han Tan and
Tadashi Anan and
Ai Kametaka and
Yoshiaki Azuma and
Keith D. Wilkinson and
Mary Dasso SUSP1 antagonizes formation of highly
SUMO2/$3$-conjugated species . . . . . . 939
Weidong Yang and
Siegfried M. Musser Nuclear import time and transport
efficiency depend on importin $ \beta $
concentration . . . . . . . . . . . . . 951
Qiuyan Wang and
Lianyun Li and
Yihong Ye Regulation of retrotranslocation by
p97-associated deubiquitinating enzyme
ataxin-3 . . . . . . . . . . . . . . . . 963
Chao-Wen Wang and
Susan Hamamoto and
Lelio Orci and
Randy Schekman Exomer: a coat complex for transport of
select membrane proteins from the
trans-Golgi network to the plasma
membrane in yeast . . . . . . . . . . . 973
Delphine Poncet and
Anne-Laure Pauleau and
Gyorgy Szabadkai and
Angelo Vozza and
Sebastian R. Scholz and
Morgane Le Bras and
Jean-Jacques Bri\`ere and
Abdelali Jalil and
Ronan Le Moigne and
Catherine Brenner and
Gabriele Hahn and
Ilka Wittig and
Hermann Schägger and
Christophe Lemaire and
Katiuscia Bianchi and
Sylvie Souqu\`ere and
Gerard Pierron and
Pierre Rustin and
Victor S. Goldmacher and
Rosario Rizzuto and
Ferdinando Palmieri and
Guido Kroemer Cytopathic effects of the
cytomegalovirus-encoded apoptosis
inhibitory protein vMIA . . . . . . . . 985
Cecilia Czibener and
Nathan M. Sherer and
Steven M. Becker and
Marc Pypaert and
Enfu Hui and
Edwin R. Chapman and
Walther Mothes and
Norma W. Andrews Ca$^{2+}$ and synaptotagmin
VII-dependent delivery of lysosomal
membrane to nascent phagosomes . . . . . 997
Christian Clement and
Vaibhav Tiwari and
Perry M. Scanlan and
Tibor Valyi-Nagy and
Beatrice Y. J. T. Yue and
Deepak Shukla A novel role for phagocytosis-like
uptake in herpes simplex virus entry . . 1009
Rebecca A. O'Donnell and
Fiona Hackett and
Steven A. Howell and
Moritz Treeck and
Nicole Struck and
Zita Krnajski and
Chrislaine Withers-Martinez and
Tim W. Gilberger and
Michael J. Blackman Intramembrane proteolysis mediates
shedding of a key adhesin during
erythrocyte invasion by the malaria
parasite . . . . . . . . . . . . . . . . 1023
Xiaoyu Pan and
Guangshuo Ou and
Gul Civelekoglu-Scholey and
Oliver E. Blacque and
Nicholas F. Endres and
Li Tao and
Alex Mogilner and
Michel R. Leroux and
Ronald D. Vale and
Jonathan M. Scholey Mechanism of transport of IFT particles
in \bionameC. elegans cilia by the
concerted action of kinesin--II and
OSM-3 motors . . . . . . . . . . . . . . 1035
Saumen Pal and
Jing Wu and
Justin K. Murray and
Samuel H. Gellman and
Michele A. Wozniak and
Patricia J. Keely and
Meghan E. Boyer and
Timothy M. Gomez and
Sean M. Hasso and
John F. Fallon and
Emery H. Bresnick An antiangiogenic
neurokinin--B/thromboxane A2 regulatory
axis . . . . . . . . . . . . . . . . . . 1047
Lingfang Zeng and
Qingzhong Xiao and
Andriana Margariti and
Zhongyi Zhang and
Anna Zampetaki and
Seema Patel and
Maurizio C. Capogrossi and
Yanhua Hu and
Qingbo Xu HDAC3 is crucial in shear- and
VEGF-induced stem cell differentiation
toward endothelial cells . . . . . . . . 1059
Vladimir Sytnyk and
Iryna Leshchyns'ka and
Alexander G. Nikonenko and
Melitta Schachner NCAM promotes assembly and
activity-dependent remodeling of the
postsynaptic signaling complex . . . . . 1071
Masahiro Yanagisawa and
Panos Z. Anastasiadis p120 catenin is essential for
mesenchymal cadherin-mediated regulation
of cell motility and invasiveness . . . 1087
Peisong Ma and
Shannon L. Beck and
Ronald W. Raab and
Robert L. McKown and
George L. Coffman and
Atsushi Utani and
William J. Chirico and
Alan C. Rapraeger and
Gordon W. Laurie Heparanase deglycanation of syndecan-1
is required for binding of the
epithelial-restricted prosecretory
mitogen lacritin . . . . . . . . . . . . 1097
Jizhong Lou and
Tadayuki Yago and
Arkadiusz G. Klopocki and
Padmaja Mehta and
Wei Chen and
Veronika I. Zarnitsyna and
Nicolai V. Bovin and
Cheng Zhu and
Rodger P. McEver Flow-enhanced adhesion regulated by a
selectin interdomain hinge . . . . . . . 1107
Mitch Leslie A protein long shot . . . . . . . . . . 2
Mitch Leslie Not so close . . . . . . . . . . . . . . ??
Mitch Leslie Brief encounter . . . . . . . . . . . . 3
Mitch Leslie Division of labor . . . . . . . . . . . ??
Mitch Leslie Ring around the tubule . . . . . . . . . ??
William A. Wells Computing direction . . . . . . . . . . 4
William A. Wells The liver that caveolin built . . . . . ??
William A. Wells Tether before synapse . . . . . . . . . 5
William A. Wells Fixing the hole . . . . . . . . . . . . ??
William A. Wells Keeping valves clear . . . . . . . . . . ??
William A. Wells Full of sound and fury, but signifying
something: XVI International AIDS
Conference, Toronto, Canada, August
13--18, 2006 . . . . . . . . . . . . . . 6
Baoying Huang and
Tim C. Huffaker Dynamic microtubules are essential for
efficient chromosome capture and
biorientation in S. cerevisiae . . . . . 17
Dongyan Tan and
Ana B. Asenjo and
Vito Mennella and
David J. Sharp and
Hernando Sosa Kinesin-13s form rings around
microtubules . . . . . . . . . . . . . . 25
Norman Sachs and
Maaike Kreft and
Marius A. van den Bergh Weerman and
Andy J. Beynon and
Theo A. Peters and
Jan J. Weening and
Arnoud Sonnenberg Kidney failure in mice lacking the
tetraspanin CD151 . . . . . . . . . . . 33
Song-Tao Liu and
Jerome B. Rattner and
Sandra A. Jablonski and
Tim J. Yen Mapping the assembly pathways that
specify formation of the trilaminar
kinetochore plates in human cells . . . 41
Graham Dellaire and
Reagan W. Ching and
Kashif Ahmed and
Farid Jalali and
Kenneth C. K. Tse and
Robert G. Bristow and
David P. Bazett-Jones Promyelocytic leukemia nuclear bodies
behave as DNA damage sensors whose
response to DNA double-strand breaks is
regulated by NBS1 and the kinases ATM,
Chk2, and ATR . . . . . . . . . . . . . 55
Alexis J. Rodriguez and
Shailesh M. Shenoy and
Robert H. Singer and
John Condeelis Visualization of mRNA translation in
living cells . . . . . . . . . . . . . . 67
Miriam I. Rosenberg and
Sara A. Georges and
Amy Asawachaicharn and
Erwin Analau and
Stephen J. Tapscott MyoD inhibits Fstl1 and Utrn expression
by inducing transcription of miR-206 . . 77
Mara Fornaro and
Peter M. Burch and
Wentian Yang and
Lei Zhang and
Claire E. Hamilton and
Jung H. Kim and
Benjamin G. Neel and
Anton M. Bennett SHP-2 activates signaling of the nuclear
factor of activated T cells to promote
skeletal muscle growth . . . . . . . . . 87
Natasha Y. Frank and
Alvin T. Kho and
Tobias Schatton and
George F. Murphy and
Michael J. Molloy and
Qian Zhan and
Marco F. Ramoni and
Markus H. Frank and
Isaac S. Kohane and
Emanuela Gussoni Regulation of myogenic progenitor
proliferation in human fetal skeletal
muscle by BMP4 and its antagonist
Gremlin . . . . . . . . . . . . . . . . 99
Gaoxiang Ge and
Daniel S. Greenspan BMP1 controls TGF$ \beta $1 activation
via cleavage of latent TGF$ \beta
$-binding protein . . . . . . . . . . . 111
Boyi Gan and
Xu Peng and
Tamas Nagy and
Ana Alcaraz and
Hua Gu and
Jun-Lin Guan Role of FIP200 in cardiac and liver
development and its regulation of TNF$
\alpha $ and TSC--mTOR signaling
pathways . . . . . . . . . . . . . . . . 121
Tetsuhisa Otani and
Tetsuo Ichii and
Shinya Aono and
Masatoshi Takeichi Cdc42 GEF Tuba regulates the junctional
configuration of simple epithelial cells 135
Michinori Toriyama and
Tadayuki Shimada and
Ki Bum Kim and
Mari Mitsuba and
Eiko Nomura and
Kazuhiro Katsuta and
Yuichi Sakumura and
Peter Roepstorff and
Naoyuki Inagaki Shootin1: a protein involved in the
organization of an asymmetric signal for
neuronal polarization . . . . . . . . . 147
Sandrine Willaime-Morawek and
Raewyn M. Seaberg and
Claudia Batista and
Etienne Labbé and
Liliana Attisano and
Jessica A. Gorski and
Kevin R. Jones and
Angela Kam and
Cindi M. Morshead and
Derek van der Kooy Embryonic cortical neural stem cells
migrate ventrally and persist as
postnatal striatal stem cells . . . . . 159
Yun Chen and
William R. Thelin and
Bing Yang and
Sharon L. Milgram and
Ken Jacobson Transient anchorage of cross-linked
glycosyl-phosphatidylinositol--anchored
proteins depends on cholesterol, Src
family kinases, caveolin, and
phosphoinositides . . . . . . . . . . . 169
W. Brian Saunders and
Brenda L. Bohnsack and
Jennifer B. Faske and
Nicholas J. Anthis and
Kayla J. Bayless and
Karen K. Hirschi and
George E. Davis Coregulation of vascular tube
stabilization by endothelial cell TIMP-2
and pericyte TIMP-3 . . . . . . . . . . 179
Mitch Leslie Taking a Toll on neurons . . . . . . . . 194
Mitch Leslie Endosomes bring up the rear . . . . . . ??
Mitch Leslie Getting the embryo into shape . . . . . 195
Mitch Leslie Membrane backtracking . . . . . . . . . ??
Mitch Leslie Melanin's backups . . . . . . . . . . . ??
William A. Wells Rosettes for elongation . . . . . . . . 196
William A. Wells Lipid microscopy . . . . . . . . . . . . ??
William A. Wells Innate tumorigenesis . . . . . . . . . . 197
William A. Wells Mopping up chemokines . . . . . . . . . ??
William A. Wells Spinning septins . . . . . . . . . . . . ??
Michael S. Marks Darkness descends with two Rabs . . . . 199
Leonid V. Chernomordik and
Joshua Zimmerberg and
Michael M. Kozlov Membranes of the world unite! . . . . . 201
Yinghua Ma and
Jianxue Li and
Isaac Chiu and
Yawen Wang and
Jacob A. Sloane and
Jining Lü and
Bela Kosaras and
Richard L. Sidman and
Joseph J. Volpe and
Timothy Vartanian Toll-like receptor 8 functions as a
negative regulator of neurite outgrowth
and inducer of neuronal apoptosis . . . 209
Daniel Hesselson and
Judith Kimble Growth control by EGF repeats of the
\bionameC. elegans Fibulin-1C isoform 217
Sudit S. Mukhopadhyay and
Kathryn S. Leung and
M. John Hicks and
Philip J. Hastings and
Hagop Youssoufian and
Sharon E. Plon Defective mitochondrial peroxiredoxin-3
results in sensitivity to oxidative
stress in Fanconi anemia . . . . . . . . 225
Frank Vogel and
Carsten Bornhövd and
Walter Neupert and
Andreas S. Reichert Dynamic subcompartmentalization of the
mitochondrial inner membrane . . . . . . 237
Ming Li and
Danny J. Schnell Reconstitution of protein targeting to
the inner envelope membrane of
chloroplasts . . . . . . . . . . . . . . 249
Britta Mueller and
Brendan N. Lilley and
Hidde L. Ploegh SEL1L, the homologue of yeast Hrd3p, is
involved in protein dislocation from the
mammalian ER . . . . . . . . . . . . . . 261
Christina Wasmeier and
Maryse Romao and
Lynn Plowright and
Dorothy C. Bennett and
Graça Raposo and
Miguel C. Seabra Rab38 and Rab32 control post-Golgi
trafficking of melanogenic enzymes . . . 271
Jacquelyn Gerhart and
Justin Elder and
Christine Neely and
Jared Schure and
Tage Kvist and
Karen Knudsen and
Mindy George-Weinstein MyoD-positive epiblast cells regulate
skeletal muscle differentiation in the
embryo . . . . . . . . . . . . . . . . . 283
Balázs Szö\Hor and
Jude Wilson and
Helen McElhinney and
Lydia Tabernero and
Keith R. Matthews Protein tyrosine phosphatase Tb PTP1: a
molecular switch controlling life cycle
differentiation in trypanosomes . . . . 293
Sarah C. Hughes and
Richard G. Fehon Phosphorylation and activity of the
tumor suppressor Merlin and the ERM
protein Moesin are coordinately
regulated by the Slik kinase . . . . . . 305
William M. Brieher and
Hao Yuan Kueh and
Bryan A. Ballif and
Timothy J. Mitchison Rapid actin monomer--insensitive
depolymerization of \bionameListeria
actin comet tails by cofilin, coronin,
and Aip1 . . . . . . . . . . . . . . . . 315
Amlan Das and
Christine Base and
Srilakshmi Dhulipala and
Ronald R. Dubreuil Spectrin functions upstream of ankyrin
in a spectrin cytoskeleton assembly
pathway . . . . . . . . . . . . . . . . 325
Justin Sturge and
Dirk Wienke and
Clare M. Isacke Endosomes generate localized
Rho--ROCK--MLC2-based contractile
signals via Endo180 to promote adhesion
disassembly . . . . . . . . . . . . . . 337
Eileen Puklin-Faucher and
Mu Gao and
Klaus Schulten and
Viola Vogel How the headpiece hinge angle is opened:
new insights into the dynamics of
integrin activation . . . . . . . . . . 349
Beatriz G. Galvez and
Maurilio Sampaolesi and
Silvia Brunelli and
Diego Covarello and
Manuela Gavina and
Barbara Rossi and
Gabriela Constantin and
Yvan Torrente and
Giulio Cossu Correction 174, p. 231 . . . . . . . . . 361
Nicole LeBrasseur Lipids be gone . . . . . . . . . . . . . 364
Nicole LeBrasseur eIF4E exports proliferation mRNAs . . . ??
Nicole LeBrasseur Histone exchange program . . . . . . . . 365
Nicole LeBrasseur An integrin's gut instincts . . . . . . ??
Nicole LeBrasseur Cortex construction . . . . . . . . . . ??
Ruth Williams Centrosomes deliver the death blow . . . 366
Ruth Williams Cosmc converter . . . . . . . . . . . . ??
Ruth Williams tRNA transport to the nucleus . . . . . 367
Ruth Williams Ubp6 delays destruction . . . . . . . . ??
Ruth Williams Point of no return for senescence . . . ??
Kendra S. Burbank and
Aaron C. Groen and
Zachary E. Perlman and
Daniel S. Fisher and
Timothy J. Mitchison A new method reveals microtubule minus
ends throughout the meiotic spindle . . 369
Peter Varnai and
Baskaran Thyagarajan and
Tibor Rohacs and
Tamas Balla Rapidly inducible changes in
phosphatidylinositol 4,5-bisphosphate
levels influence multiple regulatory
functions of the lipid in intact living
cells . . . . . . . . . . . . . . . . . 377
Giichi Takaesu and
Jong-Sun Kang and
Gyu-Un Bae and
Min-Jeong Yi and
Clement M. Lee and
E. Premkumar Reddy and
Robert S. Krauss Activation of p38$ \alpha $ /$ \beta $
MAPK in myogenesis via binding of the
scaffold protein JLP to the cell surface
protein Cdo . . . . . . . . . . . . . . 383
Hiroshi Kimura and
Nanako Takizawa and
Eric Allemand and
Tetsuya Hori and
Francisco J. Iborra and
Naohito Nozaki and
Michiko Muraki and
Masatoshi Hagiwara and
Adrian R. Krainer and
Tatsuo Fukagawa and
Katsuya Okawa A novel histone exchange factor, protein
phosphatase 2C$ \gamma $, mediates the
exchange and dephosphorylation of
H2A--H2B . . . . . . . . . . . . . . . . 389
Mario Cioce and
Séverine Boulon and
A. Gregory Matera and
Angus I. Lamond UV-induced fragmentation of Cajal bodies 401
Biljana Culjkovic and
Ivan Topisirovic and
Lucy Skrabanek and
Melisa Ruiz-Gutierrez and
Katherine L. B. Borden eIF4E is a central node of an RNA
regulon that governs cellular
proliferation . . . . . . . . . . . . . 415
Ilham A. Muslimov and
Anna Iacoangeli and
Jürgen Brosius and
Henri Tiedge Spatial codes in dendritic BC1 RNA . . . 427
Anna Terrin and
Giulietta Di Benedetto and
Vanessa Pertegato and
York-Fong Cheung and
George Baillie and
Martin J. Lynch and
Nicola Elvassore and
Anke Prinz and
Friedrich W. Herberg and
Miles D. Houslay and
Manuela Zaccolo PGE$_1$ stimulation of HEK293 cells
generates multiple contiguous domains
with different [cAMP]: role of
compartmentalized phosphodiesterases . . 441
Jayesh C. Patel and
Jorge E. Galán Differential activation and function of
Rho GTPases during
\bionameSalmonella-host cell
interactions . . . . . . . . . . . . . . 453
Tina Izard and
Guy Tran Van Nhieu and
Philippe R. J. Bois Shigella applies molecular mimicry to
subvert vinculin and invade host cells 465
Guillaume T. Charras and
Chi-Kuo Hu and
Margaret Coughlin and
Timothy J. Mitchison Reassembly of contractile actin cortex
in cell blebs . . . . . . . . . . . . . 477
Jan Pielage and
Richard D. Fetter and
Graeme W. Davis A postsynaptic Spectrin scaffold defines
active zone size, spacing, and efficacy
at the \bionameDrosophila neuromuscular
junction . . . . . . . . . . . . . . . . 491
Robert G. Jones and
Xiufen Li and
Phillip D. Gray and
Jinqiu Kuang and
Frederic Clayton and
Wade S. Samowitz and
Blair B. Madison and
Deborah L. Gumucio and
Scott K. Kuwada Conditional deletion of $ \beta $1
integrins in the intestinal epithelium
causes a loss of Hedgehog expression,
intestinal hyperplasia, and early
postnatal lethality . . . . . . . . . . 505
Mitch Leslie Togetherness, molecular style . . . . . 516
Mitch Leslie Karyopherins play the field . . . . . . ??
Mitch Leslie Untangling a deadly conspiracy . . . . . 517
Mitch Leslie Lining up microtubules . . . . . . . . . ??
Mitch Leslie Molecular mothballs for RNA . . . . . . ??
Nicole LeBrasseur Spitz on growth control . . . . . . . . 518
Nicole LeBrasseur Fight infection with oxidation . . . . . ??
Nicole LeBrasseur A minus end checkpoint . . . . . . . . . 519
Nicole LeBrasseur Yeast's primitive urea . . . . . . . . . ??
Nicole LeBrasseur Myosin's need for speed . . . . . . . . ??
Sabrina Büttner and
Tobias Eisenberg and
Eva Herker and
Didac Carmona-Gutierrez and
Guido Kroemer and
Frank Madeo Why yeast cells can undergo apoptosis:
death in times of peace, love, and war 521
Nadine Stöhr and
Marcell Lederer and
Claudia Reinke and
Sylke Meyer and
Mechthild Hatzfeld and
Robert H. Singer and
Stefan Hüttelmaier ZBP1 regulates mRNA stability during
cellular stress . . . . . . . . . . . . 527
Gavin Chapman and
Lining Liu and
Cecilia Sahlgren and
Camilla Dahlqvist and
Urban Lendahl High levels of Notch signaling
down-regulate Numb and Numblike . . . . 535
Michelle E. King and
Ho-Man Kan and
Peter W. Baas and
Alev Erisir and
Charles G. Glabe and
George S. Bloom Tau-dependent microtubule disassembly
initiated by prefibrillar $ \beta
$-amyloid . . . . . . . . . . . . . . . 541
Bernhard Schermer and
Cristina Ghenoiu and
Malte Bartram and
Roman Ulrich Müller and
Fruzsina Kotsis and
Martin Höhne and
Wolfgang Kühn and
Manuela Rapka and
Roland Nitschke and
Hanswalter Zentgraf and
Manfred Fliegauf and
Heymut Omran and
Gerd Walz and
Thomas Benzing The von Hippel--Lindau tumor suppressor
protein controls ciliogenesis by
orienting microtubule growth . . . . . . 547
Michiru Nishita and
Sa Kan Yoo and
Akira Nomachi and
Shuichi Kani and
Nagako Sougawa and
Yasutaka Ohta and
Shinji Takada and
Akira Kikuchi and
Yasuhiro Minami Filopodia formation mediated by receptor
tyrosine kinase Ror2 is required for
Wnt5a-induced cell migration . . . . . . 555
Mizuho Fukunaga-Kalabis and
Gabriela Martinez and
Zhao-Jun Liu and
Jiri Kalabis and
Paul Mrass and
Wolfgang Weninger and
Sue M. Firth and
Nathalie Planque and
Bernard Perbal and
Meenhard Herlyn CCN3 controls $3$D spatial localization
of melanocytes in the human skin through
DDR1 . . . . . . . . . . . . . . . . . . 563
Georg H. H. Borner and
Michael Harbour and
Svenja Hester and
Kathryn S. Lilley and
Margaret S. Robinson Comparative proteomics of
clathrin-coated vesicles . . . . . . . . 571
Benjamin L. Timney and
Jaclyn Tetenbaum-Novatt and
Diana S. Agate and
Rosemary Williams and
Wenzhu Zhang and
Brian T. Chait and
Michael P. Rout Simple kinetic relationships and
nonspecific competition govern nuclear
import rates in vivo . . . . . . . . . . 579
Francesca Demarchi and
Cosetta Bertoli and
Tamara Copetti and
Isei Tanida and
Claudio Brancolini and
Eeva-Liisa Eskelinen and
Claudio Schneider Calpain is required for macroautophagy
in mammalian cells . . . . . . . . . . . 595
Lun Song and
Jingxia Li and
Dongyun Zhang and
Zheng-gang Liu and
Jianping Ye and
Qimin Zhan and
Han-Ming Shen and
Matt Whiteman and
Chuanshu Huang IKK$ \beta $ programs to turn on the
GADD45$ \alpha $-MKK4-JNK apoptotic
cascade specifically via p50 NF-$ \kappa
$B in arsenite response . . . . . . . . 607
Dion Kaiserman and
Catherina H. Bird and
Jiuru Sun and
Antony Matthews and
Kheng Ung and
James C. Whisstock and
Philip E. Thompson and
Joseph A. Trapani and
Phillip I. Bird The major human and mouse granzymes are
structurally and functionally divergent 619
Youngshil Pak and
Wioletta K. Glowacka and
M. Christine Bruce and
Nam Pham and
Daniela Rotin Transport of LAPTM5 to lysosomes
requires association with the ubiquitin
ligase Nedd4, but not LAPTM5
ubiquitination . . . . . . . . . . . . . 631
Thomas B. Nicholson and
Clifford P. Stanners Specific inhibition of GPI-anchored
protein function by homing and
self-association of specific GPI anchors 647
Cristina de Guzman Strong and
Philip W. Wertz and
Chenwei Wang and
Fan Yang and
Paul S. Meltzer and
Thomas Andl and
Sarah E. Millar and
I-Cheng Ho and
Sung-Yun Pai and
Julia A. Segre Lipid defect underlies selective skin
barrier impairment of an
epidermal-specific deletion of Gata-3 661
Saumen Pal and
Jing Wu and
Justin K. Murray and
Samuel H. Gellman and
Michele A. Wozniak and
Patricia J. Keely and
Meghan E. Boyer and
Timothy M. Gomez and
Sean M. Hasso and
John F. Fallon and
Emery H. Bresnick Correction 174, p. 1047 . . . . . . . . 671
Ruth Williams Correction 175, p. 367a . . . . . . . . 673
Nicole LeBrasseur BRCA1 in replication . . . . . . . . . . 676
Nicole LeBrasseur Peroxide detection system . . . . . . . ??
Nicole LeBrasseur Promoting ESCRT--I narcissism . . . . . 677
Nicole LeBrasseur Do-it-yourself insertion . . . . . . . . ??
Nicole LeBrasseur Damage stops bud growth . . . . . . . . ??
William A. Wells Gellular transport . . . . . . . . . . . 678
William A. Wells Fever brings in the lymphocytes . . . . ??
William A. Wells Synaptic vesicle structure . . . . . . . 679
William A. Wells Lymphocyte tracks . . . . . . . . . . . ??
William A. Wells Moving cells link membrane and actin . . ??
Davide Marenduzzo and
Kieran Finan and
Peter R. Cook The depletion attraction: an
underappreciated force driving cellular
organization . . . . . . . . . . . . . . 681
Ewa Paluch and
Jasper van der Gucht and
Cécile Sykes Cracking up: symmetry breaking in
cellular systems . . . . . . . . . . . . 687
Gayle J. Pageau and
Jeanne B. Lawrence BRCA1 foci in normal S-phase nuclei are
linked to interphase centromeres and
replication of pericentric
heterochromatin . . . . . . . . . . . . 693
Akira Motegi and
Raman Sood and
Helen Moinova and
Sanford D. Markowitz and
Pu Paul Liu and
Kyungjae Myung Human SHPRH suppresses genomic
instability through proliferating cell
nuclear antigen polyubiquitination . . . 703
Ann L. Wozniak and
Xinmin Wang and
Emily S. Stieren and
Shelby G. Scarbrough and
Cornelis J. Elferink and
Darren Boehning Requirement of biphasic calcium release
from the endoplasmic reticulum for
Fas-mediated apoptosis . . . . . . . . . 709
Daniel P. Nickerson and
Matthew West and
Greg Odorizzi Did2 coordinates Vps4-mediated
dissociation of ESCRT--III from
endosomes . . . . . . . . . . . . . . . 715
Jens Waschke and
Volker Spindler and
Paola Bruggeman and
Detlef Zillikens and
Gudula Schmidt and
Detlev Drenckhahn Inhibition of Rho A activity causes
pemphigus skin blistering . . . . . . . 721
Jorrit M. Enserink and
Marcus B. Smolka and
Huilin Zhou and
Richard D. Kolodner Checkpoint proteins control
morphogenetic events during DNA
replication stress in
\bionameSaccharomyces cerevisiae . . . . 729
Marcus B. Smolka and
Sheng-hong Chen and
Paul S. Maddox and
Jorrit M. Enserink and
Claudio P. Albuquerque and
Xiao X. Wei and
Arshad Desai and
Richard D. Kolodner and
Huilin Zhou An FHA domain-mediated protein
interaction network of Rad53 reveals its
role in polarized cell growth . . . . . 743
Jaclyn M. Jansen and
Margaret F. Barry and
Charles K. Yoo and
Eric L. Weiss Phosphoregulation of Cbk1 is critical
for RAM network control of transcription
and morphogenesis . . . . . . . . . . . 755
Silvia Brambillasca and
Monica Yabal and
Marja Makarow and
Nica Borgese Unassisted translocation of large
polypeptide domains across phospholipid
bilayers . . . . . . . . . . . . . . . . 767
Timothy J. Phalen and
Kelly Weirather and
Paula B. Deming and
Vikas Anathy and
Alan K. Howe and
Albert van der Vliet and
Thomas J. Jönsson and
Leslie B. Poole and
Nicholas H. Heintz Oxidation state governs structural
transitions in peroxiredoxin II that
correlate with cell cycle arrest and
recovery . . . . . . . . . . . . . . . . 779
Sabine Witzel and
Vitaly Zimyanin and
Filipa Carreira-Barbosa and
Masazumi Tada and
Carl-Philipp Heisenberg Wnt11 controls cell contact persistence
by local accumulation of Frizzled 7 at
the plasma membrane . . . . . . . . . . 791
Abraham Hanono and
Damien Garbett and
David Reczek and
David N. Chambers and
Anthony Bretscher EPI64 regulates microvillar subdomains
and structure . . . . . . . . . . . . . 803
Tony Chu and
Ji Sun and
Suraj Saksena and
Scott D. Emr New component of ESCRT--I regulates
endosomal sorting complex assembly . . . 815
Alexander Amerik and
Nazia Sindhi and
Mark Hochstrasser A conserved late endosome--targeting
signal required for Doa4
deubiquitylating enzyme function . . . . 825
James E. Evans and
Joshua J. Snow and
Amy L. Gunnarson and
Guangshuo Ou and
Henning Stahlberg and
Kent L. McDonald and
Jonathan M. Scholey Correction 172, p. 663 . . . . . . . . . 837
William A. Wells Essential adaptor . . . . . . . . . . . 840
William A. Wells Surviving on low energy . . . . . . . . ??
William A. Wells Dynamic uncapping . . . . . . . . . . . 841
William A. Wells Making an autophagosome . . . . . . . . ??
William A. Wells Rac controls nuclear entry . . . . . . . ??
Nicole LeBrasseur Spines slow dendrite diffusion . . . . . 842
Nicole LeBrasseur Wnt polarity relay . . . . . . . . . . . ??
Nicole LeBrasseur Pro and Gly for elasticity . . . . . . . 843
Nicole LeBrasseur An H1 to relax chromatin? . . . . . . . ??
Nicole LeBrasseur Partitioning endosomes . . . . . . . . . ??
Jonathan L. Coloff and
Jeffrey C. Rathmell Metabolic regulation of Akt: roles
reversed . . . . . . . . . . . . . . . . 845
Antonina Roll-Mecak and
Ronald D. Vale Making more microtubules by severing: a
common theme of noncentrosomal
microtubule arrays? . . . . . . . . . . 849
Rachel K. Miller and
Hiroshi Qadota and
Megan L. Landsverk and
Kristina B. Mercer and
Henry F. Epstein and
Guy M. Benian UNC-98 links an integrin-associated
complex to thick filaments in
\bionameCaenorhabditis elegans muscle 853
David Teis and
Nicole Taub and
Robert Kurzbauer and
Diana Hilber and
Mariana E. de Araujo and
Miriam Erlacher and
Martin Offterdinger and
Andreas Villunger and
Stephan Geley and
Georg Bohn and
Christoph Klein and
Michael W. Hess and
Lukas A. Huber p14--MP1-MEK1 signaling regulates
endosomal traffic and cellular
proliferation during tissue homeostasis 861
Ryo Funayama and
Motoki Saito and
Hiroko Tanobe and
Fuyuki Ishikawa Loss of linker histone H1 in cellular
senescence . . . . . . . . . . . . . . . 869
Karen McNally and
Anjon Audhya and
Karen Oegema and
Francis J. McNally Katanin controls mitotic and meiotic
spindle length . . . . . . . . . . . . . 881
Ming-Lun Chou and
Chiung-Chih Chu and
Lih-Jen Chen and
Mitsuru Akita and
Hsou-min Li Stimulation of transit-peptide release
and ATP hydrolysis by a cochaperone
during protein import into chloroplasts 893
György Szabadkai and
Katiuscia Bianchi and
Péter Várnai and
Diego De Stefani and
Mariusz R. Wieckowski and
Dario Cavagna and
Anikó I. Nagy and
Tamás Balla and
Rosario Rizzuto Chaperone-mediated coupling of
endoplasmic reticulum and mitochondrial
Ca$^{2+}$ channels . . . . . . . . . . . 901
Hél\`ene Pelicano and
Rui-hua Xu and
Min Du and
Li Feng and
Ryohei Sasaki and
Jennifer S. Carew and
Yumin Hu and
Latha Ramdas and
Limei Hu and
Michael J. Keating and
Wei Zhang and
William Plunkett and
Peng Huang Mitochondrial respiration defects in
cancer cells cause activation of Akt
survival pathway through a
redox-mediated mechanism . . . . . . . . 913
Congcong He and
Hui Song and
Tomohiro Yorimitsu and
Iryna Monastyrska and
Wei-Lien Yen and
Julie E. Legakis and
Daniel J. Klionsky Recruitment of Atg9 to the
preautophagosomal structure by Atg11 is
essential for selective autophagy in
budding yeast . . . . . . . . . . . . . 925
Toshiyuki Kawashima and
Ying Chun Bao and
Yasushi Nomura and
Yuseok Moon and
Yukio Tonozuka and
Yukinori Minoshima and
Tomonori Hatori and
Akiho Tsuchiya and
Mari Kiyono and
Tetsuya Nosaka and
Hideaki Nakajima and
David A. Williams and
Toshio Kitamura Rac1 and a GTPase-activating protein,
MgcRacGAP, are required for nuclear
translocation of STAT transcription
factors . . . . . . . . . . . . . . . . 937
Takushi Miyoshi and
Takahiro Tsuji and
Chiharu Higashida and
Maud Hertzog and
Akiko Fujita and
Shuh Narumiya and
Giorgio Scita and
Naoki Watanabe Actin turnover-dependent fast
dissociation of capping protein in the
dendritic nucleation actin network:
evidence of frequent filament severing 947
Thomas M. Huckaba and
Thomas Lipkin and
Liza A. Pon Roles of type II myosin and a
tropomyosin isoform in retrograde actin
flow in budding yeast . . . . . . . . . 957
Hideki Chiba and
Naoyuki Sakai and
Masaki Murata and
Makoto Osanai and
Takafumi Ninomiya and
Takashi Kojima and
Norimasa Sawada The nuclear receptor hepatocyte nuclear
factor 4$ \alpha $ acts as a morphogen
to induce the formation of microvilli 971
Alexander H. Licht and
Oliver T. Pein and
Lore Florin and
Bettina Hartenstein and
Hendrik Reuter and
Bernd Arnold and
Peter Lichter and
Peter Angel and
Marina Schorpp-Kistner JunB is required for endothelial cell
morphogenesis by regulating core-binding
factor $ \beta $ . . . . . . . . . . . . 981
Andrea Bertotti and
Paolo M. Comoglio and
Livio Trusolino $ \beta $4 integrin activates a
Shp2--Src signaling pathway that
sustains HGF-induced
anchorage-independent growth . . . . . . 993
Christine E. Wong and
Christian Paratore and
María T. Dours-Zimmermann and
Ariane Rochat and
Thomas Pietri and
Ueli Suter and
Dieter R. Zimmermann and
Sylvie Dufour and
Jean Paul Thiery and
Dies Meijer and
Friedrich Beermann and
Yann Barrandon and
Lukas Sommer Neural crest--derived cells with stem
cell features can be traced back to
multiple lineages in the adult skin . . 1005
Cornelia Tolg and
Sara R. Hamilton and
Kerry-Ann Nakrieko and
Fatemeh Kooshesh and
Paul Walton and
James B. McCarthy and
Mina J. Bissell and
Eva A. Turley Rhamm$^{- / -}$ fibroblasts are
defective in CD44-mediated ERK1,2
motogenic signaling, leading to
defective skin wound repair . . . . . . 1017
Hyun-Soo Je and
Feng Yang and
Jiangzheng Zhou and
Bai Lu Neurotrophin 3 induces structural and
functional modification of synapses
through distinct molecular mechanisms 1029
Daniel P. Nickerson and
Matthew West and
Greg Odorizzi Correction 175, p. 715 . . . . . . . . . 1043
Nicole LeBrasseur Partners in kinesin activation . . . . . 2
Nicole LeBrasseur PKA steers growth cones . . . . . . . . ??
Nicole LeBrasseur A dual need for myosin in wounds . . . . 3
Nicole LeBrasseur Syt-12 for spontaneous release . . . . . ??
Hema Bashyam Dying cells make a joint . . . . . . . . 4
Hema Bashyam Stretchable force sensors . . . . . . . ??
Hema Bashyam Shrinking spines . . . . . . . . . . . . 5
Hema Bashyam Skin-based immunity . . . . . . . . . . ??
Hema Bashyam Self-eating ERs . . . . . . . . . . . . ??
David D. Hackney Jump-starting kinesin . . . . . . . . . 7
T. Lynne Blasius and
Dawen Cai and
Gloria T. Jih and
Christopher P. Toret and
Kristen J. Verhey Two binding partners cooperate to
activate the molecular motor Kinesin-1 11
Katherine E. Sleeman and
Howard Kendrick and
David Robertson and
Clare M. Isacke and
Alan Ashworth and
Matthew J. Smalley Dissociation of estrogen receptor
expression and in vivo stem cell
activity in the mammary gland . . . . . 19
Masako Tamada and
Tomas D. Perez and
W. James Nelson and
Michael P. Sheetz Two distinct modes of myosin assembly
and dynamics during epithelial wound
closure . . . . . . . . . . . . . . . . 27
Erik Sahai and
Raquel Garcia-Medina and
Jacques Pouysségur and
Emmanuel Vial Smurf1 regulates tumor cell plasticity
and motility through degradation of RhoA
leading to localized inhibition of
contractility . . . . . . . . . . . . . 35
Yi-Chun Liao and
Lizhen Si and
Ralph W. deVere White and
Su Hao Lo The phosphotyrosine-independent
interaction of DLC-1 and the SH2 domain
of cten regulates focal adhesion
localization and growth suppression
activity of DLC-1 . . . . . . . . . . . 43
Dawen Cai and
Adam D. Hoppe and
Joel A. Swanson and
Kristen J. Verhey Kinesin-1 structural organization and
conformational changes revealed by FRET
stoichiometry in live cells . . . . . . 51
Petros Marangos and
Emmy W. Verschuren and
Ruby Chen and
Peter K. Jackson and
John Carroll Prophase I arrest and progression to
metaphase I in mouse oocytes are
controlled by Emi1-dependent regulation
of APC$^{\rm Cdh1}$ . . . . . . . . . . 65
Shukry J. Habib and
Thomas Waizenegger and
Agathe Niewienda and
Stefan A. Paschen and
Walter Neupert and
Doron Rapaport The N-terminal domain of Tob55 has a
receptor-like function in the biogenesis
of mitochondrial $ \beta $-barrel
proteins . . . . . . . . . . . . . . . . 77
Anna Zagórska and
Eulalia Pozo-Guisado and
Jérôme Boudeau and
Alberto C. Vitari and
Fatema H. Rafiqi and
Jacob Thastrup and
Maria Deak and
David G. Campbell and
Nick A. Morrice and
Alan R. Prescott and
Dario R. Alessi Regulation of activity and localization
of the WNK1 protein kinase by
hyperosmotic stress . . . . . . . . . . 89
Jianzhong Han and
Liang Han and
Priyanka Tiwari and
Zhexing Wen and
James Q. Zheng Spatial targeting of type II protein
kinase A to filopodia mediates the
regulation of growth cone guidance by
cAMP . . . . . . . . . . . . . . . . . . 101
Anton Maximov and
Ok-Ho Shin and
Xinran Liu and
Thomas C. Südhof Synaptotagmin-12, a synaptic vesicle
phosphoprotein that modulates
spontaneous neurotransmitter release . . 113
Frédéric Relaix and
Didier Montarras and
Stéphane Zaffran and
Barbara Gayraud-Morel and
Didier Rocancourt and
Shahragim Tajbakhsh and
Ahmed Mansouri and
Ana Cumano and
Margaret Buckingham Correction 172, p. 91 . . . . . . . . . 125
Mitch Leslie Casting NETs for microbes . . . . . . . 128
Mitch Leslie Helping cells achieve oneness . . . . . ??
Mitch Leslie Meting out mitochondria . . . . . . . . 129
Mitch Leslie Thrown for a D-loop . . . . . . . . . . ??
Mitch Leslie Cycling on without centrosomes . . . . . ??
Mike Rossner Hwang case review committee misses the
mark . . . . . . . . . . . . . . . . . . 131
David Landeira and
Miguel Navarro Nuclear repositioning of the VSG
promoter during developmental silencing
in Trypanosoma brucei . . . . . . . . . 133
Jiuya He and
Chih-Chieh Mao and
Aurelio Reyes and
Hiroshi Sembongi and
Miriam Di Re and
Caroline Granycome and
Andrew B. Clippingdale and
Ian M. Fearnley and
Michael Harbour and
Alan J. Robinson and
Stefanie Reichelt and
Johannes N. Spelbrink and
John E. Walker and
Ian J. Holt The AAA$^+$ protein ATAD3 has
displacement loop binding properties and
is involved in mitochondrial nucleoid
organization . . . . . . . . . . . . . . 141
Terry Lechler and
Elaine Fuchs Desmoplakin: an unexpected regulator of
microtubule organization in the
epidermis . . . . . . . . . . . . . . . 147
Ayako Sakaguchi and
Ruth Steward Aberrant monomethylation of histone H4
lysine 20 activates the DNA damage
checkpoint in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 155
Vanja Pekovic and
Jens Harborth and
Jos L. V. Broers and
Frans C. S. Ramaekers and
Baziel van Engelen and
Martin Lammens and
Thomas von Zglinicki and
Roland Foisner and
Chris Hutchison and
Ewa Markiewicz Nucleoplasmic LAP2$ \alpha $-lamin A
complexes are required to maintain a
proliferative state in human fibroblasts 163
Yumi Uetake and
Jadranka Lon\vcarek and
Joshua J. Nordberg and
Christopher N. English and
Sabrina La Terra and
Alexey Khodjakov and
Greenfield Sluder Cell cycle progression and de novo
centriole assembly after centrosomal
removal in untransformed human cells . . 173
Dina Dikovskaya and
David Schiffmann and
Ian P. Newton and
Abigail Oakley and
Karin Kroboth and
Owen Sansom and
Thomas J. Jamieson and
Valerie Meniel and
Alan Clarke and
Inke S. Näthke Loss of APC induces polyploidy as a
result of a combination of defects in
mitosis and apoptosis . . . . . . . . . 183
Luis J. García-Rodríguez and
Anna Card Gay and
Liza A. Pon Puf3p, a Pumilio family RNA binding
protein, localizes to mitochondria and
regulates mitochondrial biogenesis and
motility in budding yeast . . . . . . . 197
Maxwell G. Heiman and
Alex Engel and
Peter Walter The Golgi-resident protease Kex2 acts in
conjunction with Prm1 to facilitate cell
fusion during yeast mating . . . . . . . 209
Elena Cibrián-Uhalte and
Adam Langenbacher and
Xiaodong Shu and
Jau-Nian Chen and
Salim Abdelilah-Seyfried Involvement of zebrafish Na$^+$ ,K$^+$
ATPase in myocardial cell junction
maintenance . . . . . . . . . . . . . . 223
Tobias A. Fuchs and
Ulrike Abed and
Christian Goosmann and
Robert Hurwitz and
Ilka Schulze and
Volker Wahn and
Yvette Weinrauch and
Volker Brinkmann and
Arturo Zychlinsky Novel cell death program leads to
neutrophil extracellular traps . . . . . 231
Mitch Leslie Nervous breakdown . . . . . . . . . . . 244
Mitch Leslie Caught in the middle . . . . . . . . . . ??
Mitch Leslie Liberating TGF$ \beta $ . . . . . . . . 245
Mitch Leslie How kinases dodge trouble . . . . . . . ??
Mitch Leslie Stem cell side show . . . . . . . . . . ??
Ruth Williams Proteasomes on ES cell patrol . . . . . 246
Ruth Williams Stabilizing the microtubule scaffold . . ??
Ruth Williams Transient silencing made permanent . . . 247
Ruth Williams Pom1p prevents a spreading middle . . . ??
Ruth Williams Clustering creates a spindle . . . . . . ??
Jennifer Greaves and
Luke H. Chamberlain Palmitoylation-dependent protein sorting 249
Rudy Behnia and
Francis A. Barr and
John J. Flanagan and
Charles Barlowe and
Sean Munro The yeast orthologue of GRASP65 forms a
complex with a coiled-coil protein that
contributes to ER to Golgi traffic . . . 255
Adam C. Smith and
Won Do Heo and
Virginie Braun and
Xiuju Jiang and
Chloe Macrae and
James E. Casanova and
Marci A. Scidmore and
Sergio Grinstein and
Tobias Meyer and
John H. Brumell A network of Rab GTPases controls
phagosome maturation and is modulated by
Salmonella enterica serovar Typhimurium 263
Marc Hammarlund and
Erik M. Jorgensen and
Michael J. Bastiani Axons break in animals lacking $ \beta
$-spectrin . . . . . . . . . . . . . . . 269
Matthew Grove and
Noboru H. Komiyama and
Klaus-Armin Nave and
Seth G. Grant and
Diane L. Sherman and
Peter J. Brophy FAK is required for axonal sorting by
Schwann cells . . . . . . . . . . . . . 277
Jérôme Govin and
Emmanuelle Escoffier and
Sophie Rousseaux and
Lauriane Kuhn and
Myriam Ferro and
Julien Thévenon and
Raffaella Catena and
Irwin Davidson and
Jérôme Garin and
Saadi Khochbin and
Cécile Caron Pericentric heterochromatin
reprogramming by new histone variants
during mouse spermiogenesis . . . . . . 283
Julien Dumont and
Sebastian Petri and
Franz Pellegrin and
Marie-Emilie Terret and
Markus T. Bohnsack and
Pascale Rassinier and
Virginie Georget and
Petr Kalab and
Oliver J. Gruss and
Marie-Hél\`ene Verlhac A centriole- and RanGTP-independent
spindle assembly pathway in meiosis I of
vertebrate oocytes . . . . . . . . . . . 295
Nobuyuki Shimohata and
Shushi Nagamori and
Yoshinori Akiyama and
H. Ronald Kaback and
Koreaki Ito SecY alterations that impair membrane
protein folding and generate a membrane
stress . . . . . . . . . . . . . . . . . 307
Atin K. Mandal and
Paul Lee and
Jennifer A. Chen and
Nadinath Nillegoda and
Alana Heller and
Susan DiStasio and
Handy Oen and
Jacob Victor and
Devi M. Nair and
Jeffrey L. Brodsky and
Avrom J. Caplan Cdc37 has distinct roles in protein
kinase quality control that protect
nascent chains from degradation and
promote posttranslational maturation . . 319
Tomomi Oyama and
Toshio Nagai and
Hiroshi Wada and
Atsuhiko Thomas Naito and
Katsuhisa Matsuura and
Koji Iwanaga and
Toshinao Takahashi and
Motohiro Goto and
Yoko Mikami and
Noritaka Yasuda and
Hiroshi Akazawa and
Akiyoshi Uezumi and
Shin'ichi Takeda and
Issei Komuro Cardiac side population cells have a
potential to migrate and differentiate
into cardiomyocytes in vitro and in vivo 329
Kun Ling and
Shawn F. Bairstow and
Chateen Carbonara and
Dmitry A. Turbin and
David G. Huntsman and
Richard A. Anderson Type I$ \gamma $ phosphatidylinositol
phosphate kinase modulates adherens
junction and E-cadherin trafficking via
a direct interaction with $ \mu $1B
adaptin . . . . . . . . . . . . . . . . 343
Shazia S. Chaudhry and
Stuart A. Cain and
Amanda Morgan and
Sarah L. Dallas and
C. Adrian Shuttleworth and
Cay M. Kielty Fibrillin-1 regulates the
bioavailability of TGF$ \beta $1 . . . . 355
Dina Dikovskaya and
David Schiffmann and
Ian P. Newton and
Abigail Oakley and
Karin Kroboth and
Owen Sansom and
Thomas J. Jamieson and
Valerie Meniel and
Alan Clarke and
Inke S. Näthke Correction 176, p. 183 . . . . . . . . . 369
Nicole LeBrasseur Endocytosis pulls Notch apart . . . . . 372
Nicole LeBrasseur Pinched off membrane . . . . . . . . . . ??
Nicole LeBrasseur Vesicles fall for traps . . . . . . . . 373
Nicole LeBrasseur Pro-diversity mitofusins . . . . . . . . ??
Nicole LeBrasseur Hydin flips flagella . . . . . . . . . . ??
Mitch Leslie Coddling cancer . . . . . . . . . . . . 374
Mitch Leslie Chromosomes can't let go . . . . . . . . ??
Mitch Leslie RECQ1's double duty . . . . . . . . . . 375
Mitch Leslie Keeping sisters close . . . . . . . . . ??
Mitch Leslie Why are cells so tense? . . . . . . . . ??
William A. Wells The returning tide . . . . . . . . . . . 376
Elizabeth F. Smith Hydin seek: finding a function in
ciliary motility . . . . . . . . . . . . 403
Scott A. Detmer and
David C. Chan Complementation between mouse Mfn1 and
Mfn2 protects mitochondrial fusion
defects caused by CMT2A disease
mutations . . . . . . . . . . . . . . . 405
Edwina Naik and
Ewa M. Michalak and
Andreas Villunger and
Jerry M. Adams and
Andreas Strasser Ultraviolet radiation triggers apoptosis
of fibroblasts and skin keratinocytes
mainly via the BH3-only protein Noxa . . 415
Vivien R. Sutton and
Nigel J. Waterhouse and
Kylie A. Browne and
Karin Sedelies and
Annette Ciccone and
Desiree Anthony and
Aulikki Koskinen and
Arno Mullbacher and
Joseph A. Trapani Residual active granzyme B in cathepsin
C--null lymphocytes is sufficient for
perforin-dependent target cell apoptosis 425
Sean P. Cullen and
Colin Adrain and
Alexander U. Lüthi and
Patrick J. Duriez and
Seamus J. Martin Human and murine granzyme B exhibit
divergent substrate preferences . . . . 435
James T. Nichols and
Alison Miyamoto and
Samantha L. Olsen and
Brendan D'Souza and
Christine Yao and
Gerry Weinmaster DSL ligand endocytosis physically
dissociates Notch1 heterodimers before
activating proteolysis can occur . . . . 445
Marie Johansson and
Nuno Rocha and
Wilbert Zwart and
Ingrid Jordens and
Lennert Janssen and
Coenraad Kuijl and
Vesa M. Olkkonen and
Jacques Neefjes Activation of endosomal dynein motors by
stepwise assembly of
Rab7--RILP--p150$^{\rm Glued}$, ORP1L,
and the receptor $ \beta $ lll spectrin 459
Karl-Ferdinand Lechtreck and
George B. Witman Chlamydomonas reinhardtii hydin is a
central pair protein required for
flagellar motility . . . . . . . . . . . 473
Véronique Dubreuil and
Anne-Marie Marzesco and
Denis Corbeil and
Wieland B. Huttner and
Michaela Wilsch-Bräuninger Midbody and primary cilium of neural
progenitors release extracellular
membrane particles enriched in the stem
cell marker prominin-1 . . . . . . . . . 483
Hadas Erez and
Guy Malkinson and
Masha Prager-Khoutorsky and
Chris I. De Zeeuw and
Casper C. Hoogenraad and
Micha E. Spira Formation of microtubule-based traps
controls the sorting and concentration
of vesicles to restricted sites of
regenerating neurons after axotomy . . . 497
Yang Yang and
Yasuhiro Ogawa and
Kristian L. Hedstrom and
Matthew N. Rasband $ \beta $IV spectrin is recruited to
axon initial segments and nodes of
Ranvier by ankyrinG . . . . . . . . . . 509
Olga G. Shcherbakova and
Carl M. Hurt and
Yang Xiang and
Mark L. Dell'Acqua and
Qi Zhang and
Richard W. Tsien and
Brian K. Kobilka Organization of $ \beta $-adrenoceptor
signaling compartments by sympathetic
innervation of cardiac myocytes . . . . 521
Devashish Kothapalli and
Liang Zhao and
Elizabeth A. Hawthorne and
Yan Cheng and
Eric Lee and
Ellen Puré and
Richard K. Assoian Hyaluronan and CD44 antagonize
mitogen-dependent cyclin D1 expression
in mesenchymal cells . . . . . . . . . . 535
Masako Tamada and
Tomas D. Perez and
W. James Nelson and
Michael P. Sheetz Two distinct modes of myosin assembly
and dynamics during epithelial wound
closure . . . . . . . . . . . . . . . . 545
Ruth Williams Vascular permeability: the flow factor 548
Ruth Williams Early and late recombination roadblocks ??
Ruth Williams Dynactin drives dynein without
microtubule binding . . . . . . . . . . 549
Ruth Williams Stalling secretase assembly . . . . . . ??
Ruth Williams Glycosylation PERKs . . . . . . . . . . ??
William A. Wells How to make less webby webs . . . . . . 550
William A. Wells Evolving folding . . . . . . . . . . . . ??
William A. Wells Chemokine blockade . . . . . . . . . . . 551
William A. Wells Pass the cycloheximide . . . . . . . . . ??
William A. Wells Motoring to a signaling check-up . . . . ??
William A. Wells and
Nicole LeBrasseur Cells in the Sun: The American Society
for Cell Biology, San Diego, CA,
December 9--13, 2006 . . . . . . . . . . 552
Johannes M. Herrmann and
Roman Köhl Catch me if you can! Oxidative protein
trapping in the intermembrane space of
mitochondria . . . . . . . . . . . . . . 559
Fabio Spada and
Andrea Haemmer and
David Kuch and
Ulrich Rothbauer and
Lothar Schermelleh and
Elisabeth Kremmer and
Thomas Carell and
Gernot Längst and
Heinrich Leonhardt DNMT1 but not its interaction with the
replication machinery is required for
maintenance of DNA methylation in human
cells . . . . . . . . . . . . . . . . . 565
Miguel Vicente-Manzanares and
Jessica Zareno and
Leanna Whitmore and
Colin K. Choi and
Alan F. Horwitz Regulation of protrusion, adhesion
dynamics, and polarity by myosins IIA
and IIB in migrating cells . . . . . . . 573
Sergey Kuznetsov and
Manuela Pellegrini and
Kristy Shuda and
Oscar Fernandez-Capetillo and
Yilun Liu and
Betty K. Martin and
Sandra Burkett and
Eileen Southon and
Debananda Pati and
Lino Tessarollo and
Stephen C. West and
Peter J. Donovan and
Andre Nussenzweig and
Shyam K. Sharan RAD51C deficiency in mice results in
early prophase I arrest in males and
sister chromatid separation at metaphase
II in females . . . . . . . . . . . . . 581
Ashraf Malhas and
Chiu Fan Lee and
Rebecca Sanders and
Nigel J. Saunders and
David J. Vaux Defects in lamin B1 expression or
processing affect interphase chromosome
position and gene expression . . . . . . 593
Jie Shang and
Ningguo Gao and
Randal J. Kaufman and
David Ron and
Heather P. Harding and
Mark A. Lehrman Translation attenuation by PERK balances
ER glycoprotein synthesis with
lipid-linked oligosaccharide flux . . . 605
Jhansi Kota and
C. Fredrik Gilstring and
Per O. Ljungdahl Membrane chaperone Shr3 assists in
folding amino acid permeases preventing
precocious ERAD . . . . . . . . . . . . 617
Dragana Spasic and
Tim Raemaekers and
Katleen Dillen and
Ilse Declerck and
Veerle Baert and
Lutgarde Serneels and
Joachim Füllekrug and
Wim Annaert Rer1p competes with APH-1 for binding to
nicastrin and regulates $ \gamma
$-secretase complex assembly in the
early secretory pathway . . . . . . . . 629
Hwajin Kim and
Shuo-Chien Ling and
Gregory C. Rogers and
Comert Kural and
Paul R. Selvin and
Stephen L. Rogers and
Vladimir I. Gelfand Microtubule binding by dynactin is
required for microtubule organization
but not cargo transport . . . . . . . . 641
Yuqing Hou and
Hongmin Qin and
John A. Follit and
Gregory J. Pazour and
Joel L. Rosenbaum and
George B. Witman Functional analysis of an individual IFT
protein: IFT46 is required for transport
of outer dynein arms into flagella . . . 653
Markus Schober and
Srikala Raghavan and
Maria Nikolova and
Lisa Polak and
H. Amalia Pasolli and
Hilary E. Beggs and
Louis F. Reichardt and
Elaine Fuchs Focal adhesion kinase modulates tension
signaling to control actin and focal
adhesion dynamics . . . . . . . . . . . 667
Andreas von Knethen and
Mathias Soller and
Nico Tzieply and
Andreas Weigert and
Axel M. Johann and
Carla Jennewein and
Roman Köhl and
Bernhard Brüne PPAR$ \gamma $1 attenuates cytosol to
membrane translocation of PKC$ \alpha $
to desensitize monocytes/macrophages . . 681
Hideki Niimi and
Katerina Pardali and
Michael Vanlandewijck and
Carl-Henrik Heldin and
Aristidis Moustakas Notch signaling is necessary for
epithelial growth arrest by TGF-$ \beta
$ . . . . . . . . . . . . . . . . . . . 695
Chunxi Ge and
Guozhi Xiao and
Di Jiang and
Renny T. Franceschi Critical role of the extracellular
signal-regulated kinase-MAPK pathway in
osteoblast differentiation and skeletal
development . . . . . . . . . . . . . . 709
A. Wayne Orr and
Rebecca Stockton and
Michael B. Simmers and
John M. Sanders and
Ian J. Sarembock and
Brett R. Blackman and
Martin Alexander Schwartz Matrix-specific p21-activated kinase
activation regulates vascular
permeability in atherogenesis . . . . . 719
Mitch Leslie A simple reentry into the cell cycle . . 730
Mitch Leslie How CENP--A reaches the centromere . . . ??
Mitch Leslie A sloppy checkpoint . . . . . . . . . . 731
Mitch Leslie Muscle first in neurodegenerative
disease? . . . . . . . . . . . . . . . . ??
Mitch Leslie Die another way . . . . . . . . . . . . ??
Nicole LeBrasseur Stress stunts organ growth . . . . . . . 732
Nicole LeBrasseur Death by default . . . . . . . . . . . . ??
Nicole LeBrasseur Sticky fingers for migration . . . . . . 733
Nicole LeBrasseur Myosin paces on microtubules . . . . . . ??
Nicole LeBrasseur Viruses infect filopodia . . . . . . . . ??
Christopher W. Carroll and
Aaron F. Straight Centromeric chromatin gets loaded . . . 735
Carl S. Thummel To die or not to die --- a role for Fork
head . . . . . . . . . . . . . . . . . . 737
Ewelina Bolcun-Filas and
Yael Costa and
Robert Speed and
Mary Taggart and
Ricardo Benavente and
Dirk G. De Rooij and
Howard J. Cooke SYCE2 is required for synaptonemal
complex assembly, double strand break
repair, and homologous recombination . . 741
Dorothee Deckbar and
Julie Birraux and
Andrea Krempler and
Leopoldine Tchouandong and
Andrea Beucher and
Sarah Walker and
Tom Stiff and
Penny Jeggo and
Markus Löbrich Chromosome breakage after G2 checkpoint
release . . . . . . . . . . . . . . . . 749
Paul S. Maddox and
Francie Hyndman and
Joost Monen and
Karen Oegema and
Arshad Desai Functional genomics identifies a Myb
domain--containing protein family
required for assembly of CENP--A
chromatin . . . . . . . . . . . . . . . 757
Katherine S. Brown and
Michael D. Blower and
Thomas J. Maresca and
Timothy C. Grammer and
Richard M. Harland and
Rebecca Heald Xenopus tropicalis egg extracts provide
insight into scaling of the mitotic
spindle . . . . . . . . . . . . . . . . 765
Bing He and
Fengong Xi and
Jian Zhang and
Daniel TerBush and
Xiaoyu Zhang and
Wei Guo Exo70p mediates the secretion of
specific exocytic vesicles at early
stages of the cell cycle for polarized
cell growth . . . . . . . . . . . . . . 771
Junichi Ikenouchi and
Kazuaki Umeda and
Sachiko Tsukita and
Mikio Furuse and
Shoichiro Tsukita Requirement of ZO-1 for the formation of
belt-like adherens junctions during
epithelial cell polarization . . . . . . 779
Zhiwei Yang and
Zhenyu Mu and
Branka Dabovic and
Vladimir Jurukovski and
Dawen Yu and
Joanne Sung and
Xiaozhong Xiong and
John S. Munger Absence of integrin-mediated TGF$ \beta
$1 activation in vivo recapitulates the
phenotype of TGF$ \beta $1-null mice . . 787
Lars E. T. Jansen and
Ben E. Black and
Daniel R. Foltz and
Don W. Cleveland Propagation of centromeric chromatin
requires exit from mitosis . . . . . . . 795
Deborah Pajalunga and
Alessia Mazzola and
Anna Maria Salzano and
Maria Grazia Biferi and
Gabriele De Luca and
Marco Crescenzi Critical requirement for cell cycle
inhibitors in sustaining
nonproliferative states . . . . . . . . 807
Lai-Wa Tam and
Nedra F. Wilson and
Paul A. Lefebvre A CDK-related kinase regulates the
length and assembly of flagella in
Chlamydomonas . . . . . . . . . . . . . 819
T. K. Rajendra and
Graydon B. Gonsalvez and
Michael P. Walker and
Karl B. Shpargel and
Helen K. Salz and
A. Gregory Matera A \bionameDrosophila melanogaster model
of spinal muscular atrophy reveals a
function for SMN in striated muscle . . 831
Chike Cao and
Yanling Liu and
Michael Lehmann Fork head controls the timing and tissue
selectivity of steroid-induced
developmental cell death . . . . . . . . 843
Hiroshi Ueda and
Ryousuke Fujita and
Akira Yoshida and
Hayato Matsunaga and
Mutsumi Ueda Identification of prothymosin-$ \alpha
$1, the necrosis--apoptosis switch
molecule in cortical neuronal cultures 853
Audrey Gérard and
Alexander E. E. Mertens and
Rob A. van der Kammen and
John G. Collard The Par polarity complex regulates Rap1-
and chemokine-induced T cell
polarization . . . . . . . . . . . . . . 863
Wei Zou and
Hideki Kitaura and
Jennifer Reeve and
Fanxin Long and
Victor L. J. Tybulewicz and
Sanford J. Shattil and
Mark H. Ginsberg and
F. Patrick Ross and
Steven L. Teitelbaum Syk, c--Src, the $ \alpha $ v$ \beta $3
integrin, and ITAM immunoreceptors, in
concert, regulate osteoclastic bone
resorption . . . . . . . . . . . . . . . 877
Ruth Williams Myosin mobilizes MHC . . . . . . . . . . 890
Ruth Williams Bending membrane to form filopodia . . . ??
Ruth Williams Fibulin-5 for youthful skin . . . . . . 891
Ruth Williams Macrophages boost hair growth . . . . . ??
Ruth Williams Spastin pulls tubulin out of shape . . . ??
William A. Wells Clonal diversity by asymmetry . . . . . 892
William A. Wells Destroying the messenger . . . . . . . . 893
William A. Wells Migrating toward adhesion . . . . . . . ??
William A. Wells Big mammals have big (or slow) cells . . ??
Raman Deep Singh and
Eileen L. Holicky and
Zhi-jie Cheng and
Seong-Youl Kim and
Christine L. Wheatley and
David L. Marks and
Robert Bittman and
Richard E. Pagano Inhibition of caveolar uptake, SV40
infection, and $ \beta $1-integrin
signaling by a nonnatural
glycosphingolipid stereoisomer . . . . . 895
Nao Osaka and
Takumi Takahashi and
Shiori Murakami and
Atsushi Matsuzawa and
Takuya Noguchi and
Takeshi Fujiwara and
Hiroyuki Aburatani and
Keiji Moriyama and
Kohsuke Takeda and
Hidenori Ichijo ASK1-dependent recruitment and
activation of macrophages induce hair
growth in skin wounds . . . . . . . . . 903
Hong-Guo Yu and
Douglas Koshland The Aurora kinase Ipl1 maintains the
centromeric localization of PP2A to
protect cohesin during meiosis . . . . . 911
Yekaterina Boyarchuk and
Adrian Salic and
Mary Dasso and
Alexei Arnaoutov Bub1 is essential for assembly of the
functional inner centromere . . . . . . 919
Maria Paola Paronetto and
Tilman Achsel and
Autumn Massiello and
Charles E. Chalfant and
Claudio Sette The RNA-binding protein Sam68 modulates
the alternative splicing of Bcl-x . . . 929
Sangil Lee and
Lynn Cooley Jagunal is required for reorganizing the
endoplasmic reticulum during
\bionameDrosophila oogenesis . . . . . . 941
Pieta K. Mattila and
Anette Pykäläinen and
Juha Saarikangas and
Ville O. Paavilainen and
Helena Vihinen and
Eija Jokitalo and
Pekka Lappalainen Missing-in-metastasis and IRSp53 deform
PI(4,5)P$_2$-rich membranes by an
inverse BAR domain-like mechanism . . . 953
Günther A. Rezniczek and
Patryk Konieczny and
Branislav Nikolic and
Siegfried Reipert and
Doris Schneller and
Christina Abrahamsberg and
Kay E. Davies and
Steve J. Winder and
Gerhard Wiche Plectin 1f scaffolding at the sarcolemma
of dystrophic (mdx) muscle fibers
through multiple interactions with $
\beta $-dystroglycan . . . . . . . . . . 965
Sarina Meinen and
Patrizia Barzaghi and
Shuo Lin and
Hanns Lochmüller and
Markus A. Ruegg Linker molecules between laminins and
dystroglycan ameliorate laminin-$ \alpha
$2--deficient muscular dystrophy at all
disease stages . . . . . . . . . . . . . 979
Susan Roehl White and
Katia J. Evans and
Jeffrey Lary and
James L. Cole and
Brett Lauring Recognition of C-terminal amino acids in
tubulin by pore loops in Spastin is
important for microtubule severing . . . 995
Fulvia Vascotto and
Danielle Lankar and
Gabrielle Faure-André and
Pablo Vargas and
Jheimmy Diaz and
Delphine Le Roux and
Maria-Isabel Yuseff and
Jean-Baptiste Sibarita and
Marianne Boes and
Graça Raposo and
Evelyne Mougneau and
Nicolas Glaichenhaus and
Christian Bonnerot and
Bénédicte Manoury and
Ana-Maria Lennon-Duménil The actin-based motor protein myosin II
regulates MHC class II trafficking and
BCR-driven antigen presentation . . . . 1007
Taeck J. Jeon and
Dai-Jen Lee and
Sylvain Merlot and
Gerald Weeks and
Richard A. Firtel Rap1 controls cell adhesion and cell
motility through the regulation of
myosin II . . . . . . . . . . . . . . . 1021
Luca Primo and
Laura di Blasio and
Cristina Roca and
Sara Droetto and
Roberto Piva and
Brian Schaffhausen and
Federico Bussolino Essential role of PDK1 in regulating
endothelial cell migration . . . . . . . 1035
Kageaki Kuribayashi and
Kiminori Nakamura and
Maki Tanaka and
Tsutomu Sato and
Junji Kato and
Katsunori Sasaki and
Rishu Takimoto and
Katsuhisa Kogawa and
Takeshi Terui and
Tetsuji Takayama and
Takayuki Onuma and
Takuya Matsunaga and
Yoshiro Niitsu Essential role of protein kinase C $
\zeta $ in transducing a motility signal
induced by superoxide and a chemotactic
peptide, fMLP . . . . . . . . . . . . . 1049
Maretoshi Hirai and
Tetsuya Ohbayashi and
Masahito Horiguchi and
Katsuya Okawa and
Akari Hagiwara and
Kenneth R. Chien and
Toru Kita and
Tomoyuki Nakamura Fibulin-5\slash DANCE has an elastogenic
organizer activity that is abrogated by
proteolytic cleavage in vivo . . . . . . 1061
Miguel Vicente-Manzanares and
Jessica Zareno and
Leanna Whitmore and
Colin K. Choi and
Alan F. Horwitz Regulation of protrusion, adhesion
dynamics, and polarity by myosins IIA
and IIB in migrating cells . . . . . . . 1073
Nicole LeBrasseur Females' regenerating advantage . . . . 2
Nicole LeBrasseur Notch remodels junctions . . . . . . . . ??
Nicole LeBrasseur Centriolar inequality . . . . . . . . . 3
Nicole LeBrasseur Bug redecorates membrane . . . . . . . . ??
Nicole LeBrasseur A myosin for basolateral sorting . . . . ??
Ruth Williams Hey, I'm still replicating! . . . . . . 4
Ruth Williams Methylate to memorize . . . . . . . . . ??
Ruth Williams Self-eating embryos . . . . . . . . . . 5
Ruth Williams Langerhans cells limit HIV invasion . . ??
Ruth Williams Tanning with p53 . . . . . . . . . . . . ??
Geoff Cumming and
Fiona Fidler and
David L. Vaux Error bars in experimental biology . . . 7
Nasser M. Rusan and
Mark Peifer A role for a novel centrosome cycle in
asymmetric cell division . . . . . . . . 13
Arlinet Kierbel and
Ama Gassama-Diagne and
Claudia Rocha and
Lilliana Radoshevich and
Joan Olson and
Keith Mostov and
Joanne Engel Pseudomonas aeruginosa exploits a
PIP3-dependent pathway to transform
apical into basolateral membrane . . . . 21
Daniel J. Kelleher and
Sulagna Banerjee and
Anthony J. Cura and
John Samuelson and
Reid Gilmore Dolichol-linked oligosaccharide
selection by the
oligosaccharyltransferase in protist and
fungal organisms . . . . . . . . . . . . 29
Taras Makhnevych and
Christopher Ptak and
C. Patrick Lusk and
John D. Aitchison and
Richard W. Wozniak The role of karyopherins in the
regulated sumoylation of septins . . . . 39
Shmuel Tuvia and
Daniel Taglicht and
Omri Erez and
Iris Alroy and
Iris Alchanati and
Vivian Bicoviski and
Mally Dori-Bachash and
Danny Ben-Avraham and
Yuval Reiss The ubiquitin E3 ligase POSH regulates
calcium homeostasis through spatial
control of Herp . . . . . . . . . . . . 51
Martin E. van Royen and
Sónia M. Cunha and
Maartje C. Brink and
Karin A. Mattern and
Alex L. Nigg and
Hendrikus J. Dubbink and
Pernette J. Verschure and
Jan Trapman and
Adriaan B. Houtsmuller Compartmentalization of androgen
receptor protein--protein interactions
in living cells . . . . . . . . . . . . 63
Bridget M. Deasy and
Aiping Lu and
Jessica C. Tebbets and
Joseph M. Feduska and
Rebecca C. Schugar and
Jonathan B. Pollett and
Bin Sun and
Kenneth L. Urish and
Burhan M. Gharaibeh and
Baohong Cao and
Robert T. Rubin and
Johnny Huard A role for cell sex in stem
cell-mediated skeletal muscle
regeneration: female cells have higher
muscle regeneration efficiency . . . . . 73
René Villadsen and
Agla J. Fridriksdottir and
Lone Rònnov-Jessen and
Thorarinn Gudjonsson and
Fritz Rank and
Mark A. LaBarge and
Mina J. Bissell and
Ole W. Petersen Evidence for a stem cell hierarchy in
the adult human breast . . . . . . . . . 87
Josephine Sui-Yan Au and
Claudia Puri and
Gudrun Ihrke and
John Kendrick-Jones and
Folma Buss Myosin VI is required for sorting of
AP-1B-dependent cargo to the basolateral
domain in polarized MDCK cells . . . . . 103
Todd I. Strochlic and
Thanuja Gangi Setty and
Anand Sitaram and
Christopher G. Burd Grd19\slash Snx3p functions as a
cargo-specific adapter for
retromer-dependent endocytic recycling 115
Ignacio Torrecilla and
Elizabeth J. Spragg and
Benoit Poulin and
Phillip J. McWilliams and
Sharad C. Mistry and
Andree Blaukat and
Andrew B. Tobin Phosphorylation and regulation of a G
protein--coupled receptor by protein
kinase CK2 . . . . . . . . . . . . . . . 127
Muriel Grammont Adherens junction remodeling by the
Notch pathway in \bionameDrosophila
melanogaster oogenesis . . . . . . . . . 139
Jolanta Chmielowiec and
Malgorzata Borowiak and
Markus Morkel and
Theresia Stradal and
Barbara Munz and
Sabine Werner and
Jürgen Wehland and
Carmen Birchmeier and
Walter Birchmeier c-Met is essential for wound healing in
the skin . . . . . . . . . . . . . . . . 151
Viktor Wixler and
Stephanie Hirner and
Judith M. Müller and
Lucia Gullotti and
Carola Will and
Jutta Kirfel and
Thomas Günther and
Holm Schneider and
Anja Bosserhoff and
Hubert Schorle and
Jung Park and
Roland Schüle and
Reinhard Buettner Deficiency in the LIM-only protein Fhl2
impairs skin wound healing . . . . . . . 163
Nikolas Epp and
Gerhard Fürstenberger and
Karsten Müller and
Silvia de Juanes and
Michael Leitges and
Ingrid Hausser and
Florian Thieme and
Gerhard Liebisch and
Gerd Schmitz and
Peter Krieg 12R-lipoxygenase deficiency disrupts
epidermal barrier function . . . . . . . 173
Ruth Williams The macrophage home of HIV . . . . . . . 184
Ruth Williams Recruitment but no repair . . . . . . . ??
Ruth Williams PIP$_2$ in endocytosis . . . . . . . . . 185
Ruth Williams How ERK5 prompts proliferation . . . . . ??
Ruth Williams The critical chaperone balance . . . . . ??
Nicole LeBrasseur Mirror symmetry in division . . . . . . 186
Nicole LeBrasseur Platelets' preset lifespan . . . . . . . ??
Nicole LeBrasseur Early replication for short telomeres 187
Nicole LeBrasseur The pore slides open . . . . . . . . . . ??
Nicole LeBrasseur Plant hormone is human cytokine . . . . ??
William A. Wells Michael Rape: the biology of destruction 188
Jimmy D. Dikeakos and
Timothy L. Reudelhuber Sending proteins to dense core secretory
granules: still a lot to sort out . . . 191
Harald W. Platta and
Fouzi El Magraoui and
Daniel Schlee and
Silke Grunau and
Wolfgang Girzalsky and
Ralf Erdmann Ubiquitination of the peroxisomal import
receptor Pex5p is required for its
recycling . . . . . . . . . . . . . . . 197
Megan L. Landsverk and
Shumin Li and
Alex H. Hutagalung and
Ayaz Najafov and
Thorsten Hoppe and
José M. Barral and
Henry F. Epstein The UNC-45 chaperone mediates sarcomere
assembly through myosin degradation in
\bionameCaenorhabditis elegans . . . . . 205
Thomas B. Nicholson and
Clifford P. Stanners Identification of a novel functional
specificity signal within the GPI anchor
signal sequence of carcinoembryonic
antigen . . . . . . . . . . . . . . . . 211
Naoya Uematsu and
Eric Weterings and
Ken-ichi Yano and
Keiko Morotomi-Yano and
Burkhard Jakob and
Gisela Taucher-Scholz and
Pierre-Olivier Mari and
Dik C. van Gent and
Benjamin P. C. Chen and
David J. Chen Autophosphorylation of DNA--PK$_{CS}$
regulates its dynamics at DNA
double-strand breaks . . . . . . . . . . 219
Dong Zhang and
Gregory C. Rogers and
Daniel W. Buster and
David J. Sharp Three microtubule severing enzymes
contribute to the ``Pacman-flux''
machinery that moves chromosomes . . . . 231
Toshiyuki Oda and
Nobutaka Hirokawa and
Masahide Kikkawa Three-dimensional structures of the
flagellar dynein--microtubule complex by
cryoelectron microscopy . . . . . . . . 243
Kelly Cude and
Yupeng Wang and
Hyun-Jung Choi and
Shih-Ling Hsuan and
Honglai Zhang and
Cun-Yu Wang and
Zhengui Xia Regulation of the G2--M cell cycle
progression by the ERK5-NF$ \kappa $B
signaling pathway . . . . . . . . . . . 253
Melanie M. Brinkmann and
Eric Spooner and
Kasper Hoebe and
Bruce Beutler and
Hidde L. Ploegh and
You-Me Kim The interaction between the ER membrane
protein UNC93B and TLR3, 7, and 9 is
crucial for TLR signaling . . . . . . . 265
Rachel T. Uren and
Grant Dewson and
Lin Chen and
Stephanie C. Coyne and
David C. S. Huang and
Jerry M. Adams and
Ruth M. Kluck Mitochondrial permeabilization relies on
BH3 ligands engaging multiple
prosurvival Bcl-2 relatives, not Bak . . 277
Tong Guo and
Christopher Gregg and
Tatiana Boukh-Viner and
Pavlo Kyryakov and
Alexander Goldberg and
Simon Bourque and
Farhana Banu and
Sandra Haile and
Svetlana Milijevic and
Karen Hung Yeung San and
Jonathan Solomon and
Vivianne Wong and
Vladimir I. Titorenko A signal from inside the peroxisome
initiates its division by promoting the
remodeling of the peroxisomal membrane 289
Tao Wang and
Yuchen Jiao and
Craig Montell Dissection of the pathway required for
generation of vitamin A and for
\bionameDrosophila phototransduction . . 305
S. Clare Chung and
Andre Limnander and
Tomohiro Kurosaki and
Arthur Weiss and
Juan I. Korenbrot Coupling Ca$^{2+}$ store release to
Icrac channel activation in B
lymphocytes requires the activity of Lyn
and Syk kinases . . . . . . . . . . . . 317
Magdalena Deneka and
Annegret Pelchen-Matthews and
Rahel Byland and
Ezequiel Ruiz-Mateos and
Mark Marsh In macrophages, HIV-1 assembles into an
intracellular plasma membrane domain
containing the tetraspanins CD81, CD9,
and CD53 . . . . . . . . . . . . . . . . 329
Nils C. Gauthier and
Pascale Monzo and
Teresa Gonzalez and
Anne Doye and
Amanda Oldani and
Pierre Gounon and
Vittorio Ricci and
Mireille Cormont and
Patrice Boquet Early endosomes associated with dynamic
F-actin structures are required for late
trafficking of H. pylori VacA toxin . . 343
Yidi Sun and
Susheela Carroll and
Marko Kaksonen and
Junko Y. Toshima and
David G. Drubin PtdIns(4,5)P$_2$ turnover is required
for multiple stages during clathrin- and
actin-dependent endocytic
internalization . . . . . . . . . . . . 355
Mitch Leslie Emi1 ensures timely mitosis . . . . . . 370
Mitch Leslie Hungry cells forget which way is up . . ??
Mitch Leslie The up side of a gas shortage . . . . . 371
Mitch Leslie Breaking actin to rebuild it . . . . . . ??
Mitch Leslie When VEGF strays . . . . . . . . . . . . ??
Nicole LeBrasseur Motility from self-antigens . . . . . . 372
Nicole LeBrasseur Linking division and growth . . . . . . ??
Nicole LeBrasseur Glycan growth switch . . . . . . . . . . 373
Nicole LeBrasseur Immunity raises cholesterol . . . . . . ??
Nicole LeBrasseur Cell fate depends on Golgi . . . . . . . ??
William A. Wells Gero Miesenböck: instructing the nervous
system . . . . . . . . . . . . . . . . . 374
Charles V. Sindelar and
Kenneth H. Downing The beginning of kinesin's
force-generating cycle visualized at 9-Å
resolution . . . . . . . . . . . . . . . 377
Vincent Mirouse and
Lance L. Swick and
Nevzat Kazgan and
Daniel St Johnston and
Jay E. Brenman LKB1 and AMPK maintain epithelial cell
polarity under energetic stress . . . . 387
Karthik Venkatesh and
Onanong Chivatakarn and
Shey-Shing Sheu and
Roman J. Giger Molecular dissection of the
myelin-associated glycoprotein receptor
complex reveals cell type--specific
mechanisms for neurite outgrowth
inhibition . . . . . . . . . . . . . . . 393
Nick Gilbert and
Inga Thomson and
Shelagh Boyle and
James Allan and
Bernard Ramsahoye and
Wendy A. Bickmore DNA methylation affects nuclear
organization, histone modifications, and
linker histone binding but not chromatin
compaction . . . . . . . . . . . . . . . 401
Haomin Huang and
Jie Feng and
Jakub Famulski and
Jerome B. Rattner and
Song Tao Liu and
Gary D. Kao and
Ruth Muschel and
Gordon K. T. Chan and
Tim J. Yen Tripin\slash hSgo2 recruits MCAK to the
inner centromere to correct defective
kinetochore attachments . . . . . . . . 413
Barbara Di Fiore and
Jonathon Pines Emi1 is needed to couple DNA replication
with mitosis but does not regulate
activation of the mitotic APC/C . . . . 425
Sylwia Wasiak and
Rodolfo Zunino and
Heidi M. McBride Bax\slash Bak promote sumoylation of
DRP1 and its stable association with
mitochondria during apoptotic cell death 439
Sylvain Provot and
Dawn Zinyk and
Yasemin Gunes and
Richa Kathri and
Quynh Le and
Henry M. Kronenberg and
Randall S. Johnson and
Michael T. Longaker and
Amato J. Giaccia and
Ernestina Schipani Hif-1$ \alpha $ regulates
differentiation of limb bud mesenchyme
and joint development . . . . . . . . . 451
Tai Kiuchi and
Kazumasa Ohashi and
Souichi Kurita and
Kensaku Mizuno Cofilin promotes stimulus-induced
lamellipodium formation by generating an
abundant supply of actin monomers . . . 465
Ian C. Fields and
Elina Shteyn and
Marc Pypaert and
Véronique Proux-Gillardeaux and
Richard S. Kang and
Thierry Galli and
Heike Fölsch v-SNARE cellubrevin is required for
basolateral sorting of AP-1B-dependent
cargo in polarized epithelial cells . . 477
Stephen G. Ball and
C. Adrian Shuttleworth and
Cay M. Kielty Vascular endothelial growth factor can
signal through platelet-derived growth
factor receptors . . . . . . . . . . . . 489
Katrin Lorenz and
Carsten Grashoff and
Robert Torka and
Takao Sakai and
Lutz Langbein and
Wilhelm Bloch and
Monique Aumailley and
Reinhard Fässler Integrin-linked kinase is required for
epidermal and hair follicle
morphogenesis . . . . . . . . . . . . . 501
Dominic P. White and
Patrick T. Caswell and
Jim C. Norman $ \alpha $ v$ \beta $3 and $ \alpha $5$
\beta $1 integrin recycling pathways
dictate downstream Rho kinase signaling
to regulate persistent cell migration 515
Mark D. Bass and
Kirsty A. Roach and
Mark R. Morgan and
Zohreh Mostafavi-Pour and
Tobias Schoen and
Takashi Muramatsu and
Ulrike Mayer and
Christoph Ballestrem and
Joachim P. Spatz and
Martin J. Humphries Syndecan-4-dependent Rac1 regulation
determines directional migration in
response to the extracellular matrix . . 527
Mark M. Fuster and
Lianchun Wang and
Janice Castagnola and
Lyudmila Sikora and
Krisanavane Reddi and
Phillip H. A. Lee and
Katherine A. Radek and
Manuela Schuksz and
Joseph R. Bishop and
Richard L. Gallo and
P. Sriramarao and
Jeffrey D. Esko Genetic alteration of endothelial
heparan sulfate selectively inhibits
tumor angiogenesis . . . . . . . . . . . 539
Yael Eshed and
Konstantin Feinberg and
David J. Carey and
Elior Peles Secreted gliomedin is a perinodal matrix
component of peripheral nerves . . . . . 551
Philippe R. J. Bois and
Kamel Izeradjene and
Peter J. Houghton and
John L. Cleveland and
Janet A. Houghton and
Gerard C. Grosveld FOXO1a acts as a selective tumor
suppressor in alveolar rhabdomyosarcoma 563
Kendall Powell STALLing for signaling . . . . . . . . . 566
Kendall Powell Bim plays apoptosis offense . . . . . . ??
Kendall Powell Chemotaxis in reverse . . . . . . . . . 567
Kendall Powell Zinc messenger . . . . . . . . . . . . . ??
Kendall Powell Motoring microvillar membrane . . . . . ??
Alla Katsnelson MicroRNAs with macro effects . . . . . . 568
Alla Katsnelson Membrane recycling for mitosis . . . . . ??
Alla Katsnelson Two ways to condense . . . . . . . . . . 569
Alla Katsnelson Checkpoint yin and yang . . . . . . . . ??
Alla Katsnelson Limiting layer diffusion . . . . . . . . ??
William A. Wells Ira Mellman: from endosomes to industry 570
Tim Krüger and
Hanswalter Zentgraf and
Ulrich Scheer Intranucleolar sites of ribosome
biogenesis defined by the localization
of early binding ribosomal proteins . . 573
Ineke Keizer-Gunnink and
Arjan Kortholt and
Peter J. M. Van Haastert Chemoattractants and chemorepellents act
by inducing opposite polarity in
phospholipase C and PI3-kinase signaling 579
Fajian Hou and
Chih-Wen Chu and
Xiangduo Kong and
Kyoko Yokomori and
Hui Zou The acetyltransferase activity of San
stabilizes the mitotic cohesin at the
centromeres in a shugoshin-independent
manner . . . . . . . . . . . . . . . . . 587
Elena Chiroli and
Valentina Rossio and
Giovanna Lucchini and
Simonetta Piatti The budding yeast PP2A$^{\rm Cdc55}$
protein phosphatase prevents the onset
of anaphase in response to morphogenetic
defects . . . . . . . . . . . . . . . . 599
Xiaoli Wang and
Roger A. Herr and
Wei-Jen Chua and
Lonnie Lybarger and
Emmanuel J. H. J. Wiertz and
Ted H. Hansen Ubiquitination of serine, threonine, or
lysine residues on the cytoplasmic tail
can induce ERAD of MHC--I by viral E3
ligase mK3 . . . . . . . . . . . . . . . 613
Arnim Weber and
Stefan A. Paschen and
Klaus Heger and
Florian Wilfling and
Tobias Frankenberg and
Heike Bauerschmitt and
Barbara M. Seiffert and
Susanne Kirschnek and
Hermann Wagner and
Georg Häcker Bim$_S$-induced apoptosis requires
mitochondrial localization but not
interaction with anti-apoptotic Bcl-2
proteins . . . . . . . . . . . . . . . . 625
Satoru Yamasaki and
Kumiko Sakata-Sogawa and
Aiko Hasegawa and
Tomoyuki Suzuki and
Koki Kabu and
Emi Sato and
Tomohiro Kurosaki and
Susumu Yamashita and
Makio Tokunaga and
Keigo Nishida and
Toshio Hirano Zinc is a novel intracellular second
messenger . . . . . . . . . . . . . . . 637
Hong Sun and
Li Li and
Cécile Vercherat and
Neriman Tuba Gulbagci and
Sujata Acharjee and
Jiali Li and
Teng-Kai Chung and
Tin Htwe Thin and
Reshma Taneja Stra13 regulates satellite cell
activation by antagonizing Notch
signaling . . . . . . . . . . . . . . . 647
Bingbing X. Li and
Akiko K. Satoh and
Donald F. Ready Myosin V, Rab11, and dRip11 direct
apical secretion and cellular
morphogenesis in developing
\bionameDrosophila photoreceptors . . . 659
Russell E. McConnell and
Matthew J. Tyska Myosin-1a powers the sliding of apical
membrane along microvillar actin bundles 671
Araceli Grande-García and
Asier Echarri and
Johan de Rooij and
Nazilla B. Alderson and
Clare M. Waterman-Storer and
José M. Valdivielso and
Miguel A. del Pozo Caveolin-1 regulates cell polarization
and directional migration through Src
kinase and Rho GTPases . . . . . . . . . 683
Mica Ohara-Imaizumi and
Tomonori Fujiwara and
Yoko Nakamichi and
Tadashi Okamura and
Yoshihiro Akimoto and
Junko Kawai and
Satsuki Matsushima and
Hayato Kawakami and
Takashi Watanabe and
Kimio Akagawa and
Shinya Nagamatsu Imaging analysis reveals mechanistic
differences between first- and
second-phase insulin exocytosis . . . . 695
Ana-Maria Gaboreanu and
Ronald Hrstka and
Wenbo Xu and
Michael Shy and
John Kamholz and
Jack Lilien and
Janne Balsamo Myelin protein zero/P0 phosphorylation
and function require an adaptor protein
linking it to RACK1 and PKC$ \alpha $ 707
Kenichi G. N. Suzuki and
Takahiro K. Fujiwara and
Fumiyuki Sanematsu and
Ryota Iino and
Michael Edidin and
Akihiro Kusumi GPI-anchored receptor clusters
transiently recruit Lyn and G$ \alpha $
for temporary cluster immobilization and
Lyn activation: single-molecule tracking
study 1 . . . . . . . . . . . . . . . . 717
Kenichi G. N. Suzuki and
Takahiro K. Fujiwara and
Michael Edidin and
Akihiro Kusumi Dynamic recruitment of phospholipase C$
\gamma $ at transiently immobilized
GPI-anchored receptor clusters induces
IP$_3$ --Ca$^{2+}$ signaling:
single-molecule tracking study 2 . . . . 731
Mitch Leslie uPAR's signaling two step . . . . . . . 744
Mitch Leslie Merlin casts spell on proliferation
protein . . . . . . . . . . . . . . . . ??
Mitch Leslie Coilin to the centromere's rescue . . . 745
Mitch Leslie Closing the connexin connection . . . . ??
Mitch Leslie To build a node . . . . . . . . . . . . ??
Ruth Williams Actin's stable cable . . . . . . . . . . 746
Ruth Williams Positioning X for inactivity . . . . . . ??
Ruth Williams Cilia signaling . . . . . . . . . . . . 747
Ruth Williams The exosome exchange . . . . . . . . . . ??
Ruth Williams Peptides prompt prions . . . . . . . . . ??
Ruth Williams Scott Fraser: live action embryology . . 748
Lars Jakobsson and
Johan Kreuger and
Lena Claesson-Welsh Building blood vessels --- stem cell
models in vascular biology . . . . . . . 751
Eric Morency and
Mirna Sabra and
Frédéric Catez and
Pascale Texier and
Patrick Lomonte A novel cell response triggered by
interphase centromere structural
instability . . . . . . . . . . . . . . 757
Hugo C. Olguin and
Zhihong Yang and
Stephen J. Tapscott and
Bradley B. Olwin Reciprocal inhibition between Pax7 and
muscle regulatory factors modulates
myogenic cell fate determination . . . . 769
Takashi Yokoyama and
Kazunori Takano and
Akira Yoshida and
Fumiko Katada and
Peng Sun and
Tadaomi Takenawa and
Toshiwo Andoh and
Takeshi Endo DA-Raf1, a competent intrinsic
dominant-negative antagonist of the
Ras--ERK pathway, is required for
myogenic differentiation . . . . . . . . 781
Stefan Wöll and
Reinhard Windoffer and
Rudolf E. Leube p38 MAPK-dependent shaping of the
keratin cytoskeleton in cultured cells 795
Peter J. M. van Haastert and
Ineke Keizer-Gunnink and
Arjan Kortholt Essential role of PI3-kinase and
phospholipase A2 in
\bionameDictyostelium discoideum
chemotaxis . . . . . . . . . . . . . . . 809
Kazuhiro Aoki and
Takeshi Nakamura and
Takanari Inoue and
Tobias Meyer and
Michiyuki Matsuda An essential role for the
SHIP2-dependent negative feedback loop
in neuritogenesis of nerve growth
factor--stimulated PC12 cells . . . . . 817
Yi-Ling Lin and
Ya-Ting Lei and
Chen-Jei Hong and
Yi-Ping Hsueh Syndecan-2 induces filopodia and
dendritic spine formation via the
neurofibromin-PKA-Ena/VASP pathway . . . 829
Florence Besse and
Sara Mertel and
Robert J. Kittel and
Carolin Wichmann and
Tobias M. Rasse and
Stephan J. Sigrist and
Anne Ephrussi The Ig cell adhesion molecule Basigin
controls compartmentalization and
vesicle release at \bionameDrosophila
melanogaster synapses . . . . . . . . . 843
Yulia Dzhashiashvili and
Yanqing Zhang and
Jolanta Galinska and
Isabel Lam and
Martin Grumet and
James L. Salzer Nodes of Ranvier and axon initial
segments are ankyrin G-dependent domains
that assemble by distinct mechanisms . . 857
Shawdee Eshghi and
Mariette G. Vogelezang and
Richard O. Hynes and
Linda G. Griffith and
Harvey F. Lodish $ \alpha_4 \beta_1 $ integrin and
erythropoietin mediate temporally
distinct steps in erythropoiesis:
integrins in red cell development . . . 871
Leonie van Zeijl and
Bas Ponsioen and
Ben N. G. Giepmans and
Aafke Ariaens and
Friso R. Postma and
Péter Várnai and
Tamas Balla and
Nullin Divecha and
Kees Jalink and
Wouter H. Moolenaar Regulation of connexin43 gap junctional
communication by phosphatidylinositol
4,5-bisphosphate . . . . . . . . . . . . 881
Marcello Curto and
Banumathi K. Cole and
Dominique Lallemand and
Ching-Hui Liu and
Andrea I. McClatchey Contact-dependent inhibition of EGFR
signaling by Nf2/Merlin . . . . . . . . 893
Breann L. Wolfe and
Adriano Marchese and
JoAnn Trejo Ubiquitination differentially regulates
clathrin-dependent internalization of
protease-activated receptor-1 . . . . . 905
Stephan Nickell and
Paul S.-H. Park and
Wolfgang Baumeister and
Krzysztof Palczewski Three-dimensional architecture of murine
rod outer segments determined by
cryoelectron tomography . . . . . . . . 917
Chris D. Madsen and
Gian Maria Sarra Ferraris and
Annapaola Andolfo and
Orla Cunningham and
Nicolai Sidenius uPAR-induced cell adhesion and
migration: vitronectin provides the key 927
Kendall Powell Motoring microvillar membrane . . . . . 941
Nicole LeBrasseur Scarred by a death receptor . . . . . . 944
Nicole LeBrasseur Catastrophe gradient drives anaphase B ??
Nicole LeBrasseur The UPR for cytokinesis . . . . . . . . 945
Nicole LeBrasseur Hypoxic reaction to reactive oxygen . . ??
Nicole LeBrasseur Dynein's spindly trip . . . . . . . . . ??
Ruth Williams Mother puts organelles in their place 946
Ruth Williams Imaging individual transcription factors ??
Ruth Williams Curves are attractive . . . . . . . . . 947
Ruth Williams Steps to STIMulation . . . . . . . . . . ??
Ruth Williams New neurons' fleeting flexibility . . . ??
Ruth Williams Oliver Rando: Taking chromatin analysis
to the genomic scale . . . . . . . . . . 948
Mike Rossner and
Ira Mellman How the rich get richer . . . . . . . . 951
Jonah R. Chan Myelination: all about Rac `n' roll . . 953
Waltraud G. Müller and
Dietmar Rieder and
Tatiana S. Karpova and
Sam John and
Zlatko Trajanoski and
James G. McNally Organization of chromatin and histone
modifications at a transcription site 957
Amila Suraweera and
Olivier J. Becherel and
Philip Chen and
Natalie Rundle and
Rick Woods and
Jun Nakamura and
Magtouf Gatei and
Chiara Criscuolo and
Alessandro Filla and
Luciana Chessa and
Markus Fußer and
Bernd Epe and
Nuri Gueven and
Martin F. Lavin Senataxin, defective in ataxia
oculomotor apraxia type 2, is involved
in the defense against oxidative DNA
damage . . . . . . . . . . . . . . . . . 969
Anton Khmelinskii and
Clare Lawrence and
Johanna Roostalu and
Elmar Schiebel Cdc14-regulated midzone assembly
controls anaphase B . . . . . . . . . . 981
Dhanya K. Cheerambathur and
Gul Civelekoglu-Scholey and
Ingrid Brust-Mascher and
Patrizia Sommi and
Alex Mogilner and
Jonathan M. Scholey Quantitative analysis of an anaphase B
switch: predicted role for a microtubule
catastrophe gradient . . . . . . . . . . 995
Eric R. Griffis and
Nico Stuurman and
Ronald D. Vale Spindly, a novel protein essential for
silencing the spindle assembly
checkpoint, recruits dynein to the
kinetochore . . . . . . . . . . . . . . 1005
Alicia A. Bicknell and
Anna Babour and
Christine M. Federovitch and
Maho Niwa A novel role in cytokinesis reveals a
housekeeping function for the unfolded
protein response . . . . . . . . . . . . 1017
Eric L. Bell and
Tatyana A. Klimova and
James Eisenbart and
Carlos T. Moraes and
Michael P. Murphy and
G. R. Scott Budinger and
Navdeep S. Chandel The Q$_o$ site of the mitochondrial
complex III is required for the
transduction of hypoxic signaling via
reactive oxygen species production . . . 1029
Vanessa Barbaro and
Anna Testa and
Enzo Di Iorio and
Fulvio Mavilio and
Graziella Pellegrini and
Michele De Luca C\slash EBP$ \delta $ regulates cell
cycle and self-renewal of human limbal
stem cells . . . . . . . . . . . . . . . 1037
Yves Benninger and
Tina Thurnherr and
Jorge A. Pereira and
Sven Krause and
Xunwei Wu and
Anna Chrostek-Grashoff and
Dominik Herzog and
Klaus-Armin Nave and
Robin J. M. Franklin and
Dies Meijer and
Cord Brakebusch and
Ueli Suter and
João B. Relvas Essential and distinct roles for cdc42
and rac1 in the regulation of Schwann
cell biology during peripheral nervous
system development . . . . . . . . . . . 1051
Alessandro Nodari and
Desirée Zambroni and
Angelo Quattrini and
Felipe A. Court and
Alessandra D'Urso and
Alessandra Recchia and
Victor L. J. Tybulewicz and
Lawrence Wrabetz and
M. Laura Feltri $ \beta $1 integrin activates Rac1 in
Schwann cells to generate radial
lamellae during axonal sorting and
myelination . . . . . . . . . . . . . . 1063
Zhonghua Lu and
Hyun-Soo Je and
Paul Young and
Jimmy Gross and
Bai Lu and
Guoping Feng Regulation of synaptic growth and
maturation by a synapse-associated E3
ubiquitin ligase at the neuromuscular
junction . . . . . . . . . . . . . . . . 1077
Todd R. Flower and
Cheryl Clark-Dixon and
Cheynita Metoyer and
Hui Yang and
Runhua Shi and
Zhaojie Zhang and
Stephan N. Witt YGR198w (YPP1) targets A30P $ \alpha
$-synuclein to the vacuole for
degradation . . . . . . . . . . . . . . 1091
Anna Spagnoli and
Lynda O'Rear and
Ronald L. Chandler and
Froilan Granero-Molto and
Douglas P. Mortlock and
Agnieszka E. Gorska and
Jared A. Weis and
Lara Longobardi and
Anna Chytil and
Kimberly Shimer and
Harold L. Moses TGF-$ \beta $ signaling is essential for
joint morphogenesis . . . . . . . . . . 1105
Benjamin D. Sachs and
George S. Baillie and
Julianne R. McCall and
Melissa A. Passino and
Christian Schachtrup and
Derek A. Wallace and
Allan J. Dunlop and
Kirsty F. MacKenzie and
Enno Klussmann and
Martin J. Lynch and
Shoana L. Sikorski and
Tal Nuriel and
Igor Tsigelny and
Jin Zhang and
Miles D. Houslay and
Moses V. Chao and
Katerina Akassoglou p75 neurotrophin receptor regulates
tissue fibrosis through inhibition of
plasminogen activation via a
PDE4/cAMP\slash PKA pathway . . . . . . 1119
Evelyn Fuchs and
Alexander K. Haas and
Robert A. Spooner and
Shin-ichiro Yoshimura and
J. Michael Lord and
Francis A. Barr Specific Rab GTPase-activating proteins
define the Shiga toxin and epidermal
growth factor uptake pathways . . . . . 1133
Mitch Leslie Go forth or multiply . . . . . . . . . . 2
Mitch Leslie Death comes for the salivary gland . . . ??
Mitch Leslie Mitochondria on the MARCH . . . . . . . 3
Mitch Leslie No way to treat a tumor . . . . . . . . ??
Mitch Leslie p53 hits the brakes . . . . . . . . . . ??
Ruth Williams Tumor cells go with the flow . . . . . . 4
Ruth Williams Could rejuvenating neurons protect
against Parkinson's? . . . . . . . . . . ??
Ruth Williams Death-defying tactics . . . . . . . . . 5
Ruth Williams DIX dynamics . . . . . . . . . . . . . . ??
Ruth Williams Golgi lands new role . . . . . . . . . . ??
Nicole LeBrasseur Rebecca Worthylake: The flooding of
science . . . . . . . . . . . . . . . . 6
Vivek Tripathi and
Tirunelvely Nagarjuna and
Sagar Sengupta BLM helicase-dependent and --independent
roles of 53BP1 during replication
stress-mediated homologous recombination 9
Tim Fugmann and
Angelika Hausser and
Patrik Schöffler and
Simone Schmid and
Klaus Pfizenmaier and
Monilola A. Olayioye Regulation of secretory transport by
protein kinase D-mediated
phosphorylation of the ceramide transfer
protein . . . . . . . . . . . . . . . . 15
Gilles Gadea and
Marion de Toledo and
Christelle Anguille and
Pierre Roux Loss of p53 promotes
RhoA--ROCK-dependent cell migration and
invasion in $3$D matrices . . . . . . . 23
Eszter K. Vladar and
Tim Stearns Molecular characterization of centriole
assembly in ciliated epithelial cells 31
Anjon Audhya and
Arshad Desai and
Karen Oegema A role for Rab5 in structuring the
endoplasmic reticulum . . . . . . . . . 43
Anthony P. Manderson and
Jason G. Kay and
Luke A. Hammond and
Darren L. Brown and
Jennifer L. Stow Subcompartments of the macrophage
recycling endosome direct the
differential secretion of IL-6 and TNF$
\alpha $ . . . . . . . . . . . . . . . . 57
Mariusz Karbowski and
Albert Neutzner and
Richard J. Youle The mitochondrial E3 ubiquitin ligase
MARCH5 is required for Drp1 dependent
mitochondrial division . . . . . . . . . 71
Viravuth P. Yin and
Carl S. Thummel and
Arash Bashirullah Down-regulation of inhibitor of
apoptosis levels provides competence for
steroid-triggered cell death . . . . . . 85
Mariia Yuneva and
Nicola Zamboni and
Peter Oefner and
Ravi Sachidanandam and
Yuri Lazebnik Deficiency in glutamine but not glucose
induces MYC-dependent apoptosis in human
cells . . . . . . . . . . . . . . . . . 93
Zhexing Wen and
Liang Han and
James R. Bamburg and
Sangwoo Shim and
Guo-li Ming and
James Q. Zheng BMP gradients steer nerve growth cones
by a balancing act of LIM kinase and
Slingshot phosphatase on ADF/cofilin . . 107
Lihua Zheng and
Hwa-Jin Baek and
Gerard Karsenty and
Monica J. Justice Filamin B represses chondrocyte
hypertrophy in a Runx2/Smad3-dependent
manner . . . . . . . . . . . . . . . . . 121
Jacqueline L. Vanderluit and
Crystal A. Wylie and
Kelly A. McClellan and
Noel Ghanem and
Andre Fortin and
Steve Callaghan and
Jason G. MacLaurin and
David S. Park and
Ruth S. Slack The Retinoblastoma family member p107
regulates the rate of progenitor
commitment to a neuronal fate . . . . . 129
Xuehua Xu and
Martin Meier-Schellersheim and
Jianshe Yan and
Tian Jin Locally controlled inhibitory mechanisms
are involved in eukaryotic GPCR-mediated
chemosensing . . . . . . . . . . . . . . 141
Irwan T. Makagiansar and
Scott Williams and
Tomas Mustelin and
William B. Stallcup Differential phosphorylation of NG2
proteoglycan by ERK and PKC$ \alpha $
helps balance cell proliferation and
migration . . . . . . . . . . . . . . . 155
Seiichiro Takahashi and
Michael Leiss and
Markus Moser and
Tomoo Ohashi and
Tomoe Kitao and
Dominik Heckmann and
Alexander Pfeifer and
Horst Kessler and
Junichi Takagi and
Harold P. Erickson and
Reinhard Fässler The RGD motif in fibronectin is
essential for development but
dispensable for fibril assembly . . . . 167
Mitch Leslie Polarizing power of touch . . . . . . . 180
Mitch Leslie Kinetochores take alternative
transportation . . . . . . . . . . . . . ??
Mitch Leslie Caspase-free mitotic death . . . . . . . 181
Mitch Leslie Putting Dia1 in its place . . . . . . . ??
Mitch Leslie Self-starting slime mold . . . . . . . . ??
Ruth Williams Actin, the great orchestrator . . . . . 182
Ruth Williams Podosomes push through . . . . . . . . . ??
Ruth Williams Microbots deliver the goods . . . . . . 183
Ruth Williams Eat to compete . . . . . . . . . . . . . ??
Ruth Williams Migrating neurons keep their limbs
tucked in . . . . . . . . . . . . . . . ??
Atsuo T. Sasaki and
Chris Janetopoulos and
Susan Lee and
Pascale G. Charest and
Kosuke Takeda and
Lauren W. Sundheimer and
Ruedi Meili and
Peter N. Devreotes and
Richard A. Firtel G protein-independent Ras/PI3K/F-actin
circuit regulates basic cell motility 185
Dominique T. Brandt and
Sabrina Marion and
Gareth Griffiths and
Takashi Watanabe and
Kozo Kaibuchi and
Robert Grosse Dia1 and IQGAP1 interact in cell
migration and phagocytic cup formation 193
Azeddine Atfi and
Emmanuelle Dumont and
Frédéric Colland and
Dominique Bonnier and
Annie L'Helgoualc'h and
Céline Prunier and
Nathalie Ferrand and
Bruno Clément and
Ulla M. Wewer and
Nathalie Théret The disintegrin and metalloproteinase
ADAM12 contributes to TGF-$ \beta $
signaling through interaction with the
type II receptor . . . . . . . . . . . . 201
Jung-Ae Kim and
Michael Kruhlak and
Farokh Dotiwala and
André Nussenzweig and
James E. Haber Heterochromatin is refractory to $
\gamma $-H2AX modification in yeast and
mammals . . . . . . . . . . . . . . . . 209
Martin Leeb and
Anton Wutz Ring1B is crucial for the regulation of
developmental control genes and PRC1
proteins but not X inactivation in
embryonic cells . . . . . . . . . . . . 219
Shaogang Sun and
Yujie Tang and
Xiwen Lou and
Lianhui Zhu and
Kai Yang and
Bianhong Zhang and
Hexin Shi and
Chen Wang UXT is a novel and essential cofactor in
the NF-$ \kappa $B transcriptional
enhanceosome . . . . . . . . . . . . . . 231
Hyeseon Cho and
John H. Kehrl Localization of G$_{i \alpha }$ proteins
in the centrosomes and at the midbody:
implication for their role in cell
division . . . . . . . . . . . . . . . . 245
Helfrid Hochegger and
Donniphat Dejsuphong and
Eiichiro Sonoda and
Alihossein Saberi and
Eeson Rajendra and
Jane Kirk and
Tim Hunt and
Shunichi Takeda An essential role for Cdk1 in S phase
control is revealed via chemical
genetics in vertebrate cells . . . . . . 257
Kozo Tanaka and
Etsushi Kitamura and
Yoko Kitamura and
Tomoyuki U. Tanaka Molecular mechanisms of
microtubule-dependent kinetochore
transport toward spindle poles . . . . . 269
Yohei Niikura and
Amruta Dixit and
Ray Scott and
Guy Perkins and
Katsumi Kitagawa BUB1 mediation of caspase-independent
mitotic death determines cell fate . . . 283
Yue Sun and
Kun Ling and
Matthew P. Wagoner and
Richard A. Anderson Type I$ \gamma $ phosphatidylinositol
phosphate kinase is required for
EGF-stimulated directional cell
migration . . . . . . . . . . . . . . . 297
Tong-Wey Koh and
Viktor I. Korolchuk and
Yogesh P. Wairkar and
Wei Jiao and
Emma Evergren and
Hongling Pan and
Yi Zhou and
Koen J. T. Venken and
Oleg Shupliakov and
Iain M. Robinson and
Cahir J. O'Kane and
Hugo J. Bellen Eps15 and Dap160 control synaptic
vesicle membrane retrieval and synapse
development . . . . . . . . . . . . . . 309
Lene N. Nejsum and
W. James Nelson A molecular mechanism directly linking
E-cadherin adhesion to initiation of
epithelial cell surface polarity . . . . 323
Mitch Leslie Caching killer carbs . . . . . . . . . . 338
Mitch Leslie Splitting the difference on peroxisomes ??
Mitch Leslie Small cancer cells don't stray . . . . . 339
Mitch Leslie Separate and unequal Deltas . . . . . . ??
Nicole LeBrasseur Howard Hang: Posttranslational
pathogenesis . . . . . . . . . . . . . . 340
Tom Cech and
Jack Dixon and
Avice Meehan and
Josie Briggs and
Carl Rhodes A reply from HHMI . . . . . . . . . . . 343
Kerstin H. Thein and
Julia Kleylein-Sohn and
Erich A. Nigg and
Ulrike Gruneberg Astrin is required for the maintenance
of sister chromatid cohesion and
centrosome integrity . . . . . . . . . . 345
Karni Schlessinger and
Edward J. McManus and
Alan Hall Cdc42 and noncanonical Wnt signal
transduction pathways cooperate to
promote cell polarity . . . . . . . . . 355
Shin-ichiro Yoshimura and
Johannes Egerer and
Evelyn Fuchs and
Alexander K. Haas and
Francis A. Barr Functional dissection of Rab GTPases
involved in primary cilium formation . . 363
Jamie M. Keck and
Matthew K. Summers and
Donato Tedesco and
Susanna Ekholm-Reed and
Li-Chiou Chuang and
Peter K. Jackson and
Steven I. Reed Cyclin E overexpression impairs
progression through mitosis by
inhibiting APC$^{\rm Cdh1}$ . . . . . . 371
Shuling Fan and
Vanessa Fogg and
Qian Wang and
Xiao-Wei Chen and
Chia-Jen Liu and
Ben Margolis A novel Crumbs3 isoform regulates cell
division and ciliogenesis via importin $
\beta $ interactions . . . . . . . . . . 387
Alison M. Motley and
Ewald H. Hettema Yeast peroxisomes multiply by growth and
division . . . . . . . . . . . . . . . . 399
Jun Fang and
Joseph A. Brzostowski and
Stephen Ou and
Nilgun Isik and
Vinod Nair and
Tian Jin A vesicle surface tyrosine kinase
regulates phagosome maturation . . . . . 411
Robin D. Lester and
Minji Jo and
Valérie Montel and
Shinako Takimoto and
Steven L. Gonias uPAR induces epithelial--mesenchymal
transition in hypoxic breast cancer
cells . . . . . . . . . . . . . . . . . 425
Samy Lamouille and
Rik Derynck Cell size and invasion in TGF-$ \beta
$-induced epithelial to mesenchymal
transition is regulated by activation of
the mTOR pathway . . . . . . . . . . . . 437
Jian Li and
Peter J. Peters and
Ming Bai and
Jun Dai and
Erik Bos and
Tomas Kirchhausen and
Konstantin V. Kandror and
Victor W. Hsu An ACAP1-containing clathrin coat
complex for endocytic recycling . . . . 453
Insa Geffers and
Katrin Serth and
Gavin Chapman and
Robert Jaekel and
Karin Schuster-Gossler and
Ralf Cordes and
Duncan B. Sparrow and
Elisabeth Kremmer and
Sally L. Dunwoodie and
Thomas Klein and
Achim Gossler Divergent functions and distinct
localization of the Notch ligands DLL1
and DLL3 in vivo . . . . . . . . . . . . 465
Matthew S. Gentry and
Robert H. Dowen and
Carolyn A. Worby and
Seema Mattoo and
Joseph R. Ecker and
Jack E. Dixon The phosphatase laforin crosses
evolutionary boundaries and links
carbohydrate metabolism to neuronal
disease . . . . . . . . . . . . . . . . 477
Mian Xie and
Xiang Li and
Jing Han and
Daniel L. Vogt and
Silke Wittemann and
Melanie D. Mark and
Stefan Herlitze Facilitation versus depression in
cultured hippocampal neurons determined
by targeting of Ca$^{2+}$ channel Ca$_v$
$ \beta_4$ versus Ca$_v$ $ \beta_2$
subunits to synaptic terminals . . . . . 489
Marta Rosário and
Renate Franke and
Christien Bednarski and
Walter Birchmeier The neurite outgrowth multiadaptor
RhoGAP, NOMA--GAP, regulates neurite
extension through SHP2 and Cdc42 . . . . 503
Soichiro Yamada and
W. James Nelson Localized zones of Rho and Rac
activities drive initiation and
expansion of epithelial cell--cell
adhesion . . . . . . . . . . . . . . . . 517
Madhavi P. Maddugoda and
Matthew S. Crampton and
Annette M. Shewan and
Alpha S. Yap Myosin VI and vinculin cooperate during
the morphogenesis of cadherin cell--cell
contacts in mammalian epithelial cells 529
Ruth Williams Multifunctional BAF-1 . . . . . . . . . ??
Ruth Williams Cellular career decisions start early ??
Ruth Williams Cellular suicide pact . . . . . . . . . ??
Ruth Williams SCAPER speeds and slows the cell cycle ??
Ruth Williams Dendritic spines cut loose to mature . . ??
Kendall Powell A bouquet for meiotic spindle . . . . . ??
Kendall Powell Cells' precise pattern readout . . . . . ??
Kendall Powell SINEs create boundaries . . . . . . . . ??
Kendall Powell Fluid for a single lumen . . . . . . . . ??
Kendall Powell Collective guidance wisdom . . . . . . . ??
Nicole LeBrasseur Terry Lechler: The cytoskeleton is skin
deep . . . . . . . . . . . . . . . . . . 546
Claire Q. F. Wang and
C. Yan Cheng A seamless trespass: germ cell migration
across the seminiferous epithelium
during spermatogenesis . . . . . . . . . 549
Nafiseh Sabri and
Peggy Roth and
Nikos Xylourgidis and
Fatemeh Sadeghifar and
Jeremy Adler and
Christos Samakovlis Distinct functions of the
\bionameDrosophila Nup153 and Nup214 FG
domains in nuclear protein transport . . 557
Nichole Link and
Po Chen and
Wan-Jin Lu and
Kristi Pogue and
Amy Chuong and
Miguel Mata and
Joshua Checketts and
John M. Abrams A collective form of cell death requires
homeodomain interacting protein kinase 567
Carl U. Bialucha and
Emma C. Ferber and
Franck Pichaud and
Sew Y. Peak-Chew and
Yasuyuki Fujita p32 is a novel mammalian Lgl binding
protein that enhances the activity of
protein kinase C$ \zeta $ and regulates
cell polarity . . . . . . . . . . . . . 575
Stephanie A. Stehman and
Yu Chen and
Richard J. McKenney and
Richard B. Vallee NudE and NudEL are required for mitotic
progression and are involved in dynein
recruitment to kinetochores . . . . . . 583
Petra Mühlhäusser and
Ulrike Kutay An in vitro nuclear disassembly system
reveals a role for the RanGTPase system
and microtubule-dependent steps in
nuclear envelope breakdown . . . . . . . 595
Shu-ou Shan and
Sowmya Chandrasekar and
Peter Walter Conformational changes in the GTPase
modules of the signal reception particle
and its receptor drive initiation of
protein translocation . . . . . . . . . 611
William Y. Tsang and
Leyu Wang and
Zhihong Chen and
Irma Sánchez and
Brian David Dynlacht SCAPER, a novel cyclin A--interacting
protein that regulates cell cycle
progression . . . . . . . . . . . . . . 621
Pauline Bastide and
Charbel Darido and
Julie Pannequin and
Ralf Kist and
Sylvie Robine and
Christiane Marty-Double and
Frédéric Bibeau and
Gerd Scherer and
Dominique Joubert and
Frédéric Hollande and
Philippe Blache and
Philippe Jay Sox9 regulates cell proliferation and is
required for Paneth cell differentiation
in the intestinal epithelium . . . . . . 635
Jacquelyn Gerhart and
Christine Neely and
Justin Elder and
Jessica Pfautz and
Jordanna Perlman and
Luis Narciso and
Kersti K. Linask and
Karen Knudsen and
Mindy George-Weinstein Cells that express MyoD mRNA in the
epiblast are stably committed to the
skeletal muscle lineage . . . . . . . . 649
Ayelet Margalit and
Esther Neufeld and
Naomi Feinstein and
Katherine L. Wilson and
Benjamin Podbilewicz and
Yosef Gruenbaum Barrier to autointegration factor blocks
premature cell fusion and maintains
adult muscle integrity in \bionameC.
elegans . . . . . . . . . . . . . . . . 661
Dmitry E. Shvartsman and
John C. Donaldson and
Begoña Diaz and
Orit Gutman and
G. Steven Martin and
Yoav I. Henis Src kinase activity and SH2 domain
regulate the dynamics of Src association
with lipid and protein targets . . . . . 675
Li Tian and
Michael Stefanidakis and
Lin Ning and
Philippe Van Lint and
Henrietta Nyman-Huttunen and
Claude Libert and
Shigeyoshi Itohara and
Masayoshi Mishina and
Heikki Rauvala and
Carl G. Gahmberg Activation of NMDA receptors promotes
dendritic spine development through
MMP-mediated ICAM-5 cleavage . . . . . . 687
Chloé C. Féral and
Andries Zijlstra and
Eugene Tkachenko and
Gerald Prager and
Margaret L. Gardel and
Marina Slepak and
Mark H. Ginsberg CD98hc (SLC3A2) participates in
fibronectin matrix assembly by mediating
integrin signaling . . . . . . . . . . . 701
Alla Katsnelson Two ways to condense . . . . . . . . . . 713
Mitch Leslie Fighting Alzheimer's by defusing a death
receptor . . . . . . . . . . . . . . . . ??
Mitch Leslie The long and short of mitochondrial
fusion . . . . . . . . . . . . . . . . . ??
Mitch Leslie AIS neurofascin'd to matrix . . . . . . ??
Mitch Leslie Centering the centriole . . . . . . . . ??
Mitch Leslie To make a nuclear pore, just relax . . . ??
Ruth Williams W. Zacheus Cande: Evolutionary biologist
in cell biologist's clothing . . . . . . 718
Julie R. Perlin and
William S. Talbot Putting the glue in glia: Necls mediate
Schwann cell--axon adhesion . . . . . . 721
Eliana P. Lucas and
Jordan W. Raff Maintaining the proper connection
between the centrioles and the
pericentriolar matrix requires
\bionameDrosophila Centrosomin . . . . . 725
Graydon B. Gonsalvez and
Liping Tian and
Jason K. Ospina and
François-Michel Boisvert and
Angus I. Lamond and
A. Gregory Matera Two distinct arginine methyltransferases
are required for biogenesis of Sm-class
ribonucleoproteins . . . . . . . . . . . 733
Yuval Yung and
Janice L. Walker and
James M. Roberts and
Richard K. Assoian A Skp2 autoinduction loop and
restriction point control . . . . . . . 741
Zhiyin Song and
Hsiuchen Chen and
Maja Fiket and
Christiane Alexander and
David C. Chan OPA1 processing controls mitochondrial
fusion and is regulated by mRNA
splicing, membrane potential, and Yme1L 749
Lorena Griparic and
Takayuki Kanazawa and
Alexander M. van der Bliek Regulation of the mitochondrial
dynamin-like protein Opa1 by proteolytic
cleavage . . . . . . . . . . . . . . . . 757
Tomoko Kamasaki and
Masako Osumi and
Issei Mabuchi Three-dimensional arrangement of F-actin
in the contractile ring of fission yeast 765
Jiayin Zhang and
Sana Ahmad and
Yinghui Mao BubR1 and APC/EB1 cooperate to maintain
metaphase chromosome alignment . . . . . 773
Qian Liu and
Nelly Pante and
Tom Misteli and
Mohamed Elsagga and
Melissa Crisp and
Didier Hodzic and
Brian Burke and
Kyle J. Roux Functional association of Sun1 with
nuclear pore complexes . . . . . . . . . 785
John J. Scarcelli and
Christine A. Hodge and
Charles N. Cole The yeast integral membrane protein
Apq12 potentially links membrane
dynamics to assembly of nuclear pore
complexes . . . . . . . . . . . . . . . 799
Alaron Lewis and
Rachael Felberbaum and
Mark Hochstrasser A nuclear envelope protein linking
nuclear pore basket assembly, SUMO
protease regulation, and mRNA
surveillance . . . . . . . . . . . . . . 813
Ping He and
Zhenyu Zhong and
Kristina Lindholm and
Lilian Berning and
Wendy Lee and
Cynthia Lemere and
Matthias Staufenbiel and
Rena Li and
Yong Shen Deletion of tumor necrosis factor death
receptor inhibits amyloid $ \beta $
generation and prevents learning and
memory deficits in Alzheimer's mice . . 829
Shu Hisata and
Toshiaki Sakisaka and
Takeshi Baba and
Tomohiro Yamada and
Kazuhiro Aoki and
Michiyuki Matsuda and
Yoshimi Takai Rap1-PDZ-GEF1 interacts with a
neurotrophin receptor at late endosomes,
leading to sustained activation of Rap1
and ERK and neurite outgrowth . . . . . 843
Patrice Maurel and
Steven Einheber and
Jolanta Galinska and
Pratik Thaker and
Isabel Lam and
Marina B. Rubin and
Steven S. Scherer and
Yoshinuri Murakami and
David H. Gutmann and
James L. Salzer Nectin-like proteins mediate
axon--Schwann cell interactions along
the internode and are essential for
myelination . . . . . . . . . . . . . . 861
Kristian L. Hedstrom and
Xiaorong Xu and
Yasuhiro Ogawa and
Renato Frischknecht and
Constanze I. Seidenbecher and
Peter Shrager and
Matthew N. Rasband Neurofascin assembles a specialized
extracellular matrix at the axon initial
segment . . . . . . . . . . . . . . . . 875
Antonia H. Holway and
Seung-Hwan Kim and
Adriana La Volpe and
W. Matthew Michael Checkpoint silencing during the DNA
damage response in
\bionameCaenorhabditis elegans embryos 887
Nicole LeBrasseur Growth factors attract mRNAs . . . . . . ??
Nicole LeBrasseur Kinesin-5 reins in axon branching . . . ??
Nicole LeBrasseur Katanin cuts some, spares others . . . . ??
Nicole LeBrasseur Emerin hooks centrosome to nucleus . . . ??
Nicole LeBrasseur Pyk2 for perfect bones . . . . . . . . . ??
Mitch Leslie Wnt makes stem cells act their age . . . ??
Mitch Leslie For cdks, one is enough . . . . . . . . ??
Mitch Leslie Fusing without breaking . . . . . . . . ??
Mitch Leslie Apoptosis promoters spur cell division ??
Mitch Leslie The price of excess DNA . . . . . . . . ??
Ruth Williams Jidong Liu: Probing P-bodies for the
secrets of silencing . . . . . . . . . . 894
Georgia Salpingidou and
Andrei Smertenko and
Irena Hausmanowa-Petrucewicz and
Patrick J. Hussey and
Chris J. Hutchison A novel role for the nuclear membrane
protein emerin in association of the
centrosome to the outer nuclear membrane 897
Chandra L. Kilburn and
Chad G. Pearson and
Edwin P. Romijn and
Janet B. Meehl and
Thomas H. Giddings and
Brady P. Culver and
John R. Yates and
Mark Winey New \bionameTetrahymena basal body
protein components identify basal body
domain structure . . . . . . . . . . . . 905
Vincent van den Boom and
Susanne M. Kooistra and
Marije Boesjes and
Bart Geverts and
Adriaan B. Houtsmuller and
Koshiro Monzen and
Issei Komuro and
Jeroen Essers and
Loes J. Drenth-Diephuis and
Bart J. L. Eggen UTF1 is a chromatin-associated protein
involved in ES cell differentiation . . 913
Roberta Benetti and
Susana Gonzalo and
Isabel Jaco and
Gunnar Schotta and
Peter Klatt and
Thomas Jenuwein and
María A. Blasco Suv4-20h deficiency results in telomere
elongation and derepression of telomere
recombination . . . . . . . . . . . . . 925
Snehal Bhikhu Patel and
Natalya Novikova and
Michel Bellini Splicing-independent recruitment of
spliceosomal small nuclear RNPs to
nascent RNA polymerase II transcripts 937
Kelly P. Smith and
Meg Byron and
Carol Johnson and
Yigong Xing and
Jeanne B. Lawrence Defining early steps in mRNA transport:
mutant mRNA in myotonic dystrophy type I
is blocked at entry into SC-35 domains 951
Dianna E. Willis and
Erna A. van Niekerk and
Yukio Sasaki and
Mariano Mesngon and
Tanuja T. Merianda and
Gervan G. Williams and
Marvin Kendall and
Deanna S. Smith and
Gary J. Bassell and
Jeffery L. Twiss Extracellular stimuli specifically
regulate localized levels of individual
neuronal mRNAs . . . . . . . . . . . . . 965
Lan Xu and
Xiaohao Yao and
Xiaochu Chen and
Peiyuan Lu and
Biliang Zhang and
Y. Tony Ip Msk is required for nuclear import of
TGF-$ \beta $ /BMP-activated Smads . . . 981
Lei Xiong and
Fei Kou and
Ying Yang and
Jiarui Wu A novel role for IGF-1R in p53-mediated
apoptosis through translational
modulation of the p53-Mdm2 feedback loop 995
Qingyang Gu and
G. Tim Bowden and
Daniel Normolle and
Yi Sun SAG\slash ROC2 E3 ligase regulates skin
carcinogenesis by stage-dependent
targeting of c--Jun/AP1 and I$ \kappa
$B-$ \alpha $ /NF-$ \kappa $B . . . . . 1009
James A. Olzmann and
Lian Li and
Maksim V. Chudaev and
Jue Chen and
Francisco A. Perez and
Richard D. Palmiter and
Lih-Shen Chin Parkin-mediated K63-linked
polyubiquitination targets misfolded
DJ-1 to aggresomes via binding to HDAC6 1025
M\`onica Suelves and
Berta Vidal and
Antonio L. Serrano and
Marc Tjwa and
Josep Roma and
Roser López-Alemany and
Aernout Luttun and
María Martínez de Lagrán and
Maria \`Angels Díaz and
Merc\`e Jardí and
Manuel Roig and
Mara Dierssen and
Mieke Dewerchin and
Peter Carmeliet and
Pura Muñoz-Cánoves uPA deficiency exacerbates muscular
dystrophy in MDX mice . . . . . . . . . 1039
Hava Gil-Henn and
Olivier Destaing and
Natalie A. Sims and
Kazuhiro Aoki and
Neil Alles and
Lynn Neff and
Archana Sanjay and
Angela Bruzzaniti and
Pietro De Camilli and
Roland Baron and
Joseph Schlessinger Defective microtubule-dependent podosome
organization in osteoclasts leads to
increased bone density in Pyk2$^{- / -}$
mice . . . . . . . . . . . . . . . . . . 1053
Neeraj Sharma and
Jessica Bryant and
Dorota Wloga and
Rachel Donaldson and
Richard C. Davis and
Maria Jerka-Dziadosz and
Jacek Gaertig Katanin regulates dynamics of
microtubules and biogenesis of motile
cilia . . . . . . . . . . . . . . . . . 1065
Kenneth A. Myers and
Peter W. Baas Kinesin-5 regulates the growth of the
axon by acting as a brake on its
microtubule array . . . . . . . . . . . 1081
Mitch Leslie Starting a tumor off wrong . . . . . . . ??
Mitch Leslie Myosins pull together to move cargo . . ??
Mitch Leslie Pol II piece makes and breaks mRNA . . . ??
Mitch Leslie RhoG welcomes leukocytes . . . . . . . . ??
Mitch Leslie Going their own way in the NPC . . . . . ??
Nicole LeBrasseur Golgi helps shape dendrites . . . . . . ??
Nicole LeBrasseur Independent membrane protein clustering ??
Nicole LeBrasseur Mitochondria move to immune synapse . . ??
Nicole LeBrasseur Stick with gap junctions . . . . . . . . ??
Ruth Williams Konrad Hochedlinger: The new kid of
nuclear reprogramming . . . . . . . . . 1098
Matilde Murga and
Isabel Jaco and
Yuhong Fan and
Rebeca Soria and
Barbara Martinez-Pastor and
Myriam Cuadrado and
Seung-Min Yang and
Maria A. Blasco and
Arthur I. Skoultchi and
Oscar Fernandez-Capetillo Global chromatin compaction limits the
strength of the DNA damage response . . 1101
Christine M. Caldwell and
Rebecca A. Green and
Kenneth B. Kaplan APC mutations lead to cytokinetic
failures in vitro and tetraploid
genotypes in Min mice . . . . . . . . . 1109
Laura J. Terry and
Susan R. Wente Nuclear mRNA export requires specific FG
nucleoporins for translocation through
the nuclear pore complex . . . . . . . . 1121
Rona Lotan and
Vicky Goler-Baron and
Lea Duek and
Gal Haimovich and
Mordechai Choder The Rpb7p subunit of yeast RNA
polymerase II plays roles in the two
major cytoplasmic mRNA decay mechanisms 1133
Sébastien Durand and
Nicolas Cougot and
Florence Mahuteau-Betzer and
Chi-Hung Nguyen and
David S. Grierson and
Edouard Bertrand and
Jamal Tazi and
Fabrice Lejeune Inhibition of nonsense-mediated mRNA
decay (NMD) by a new chemical molecule
reveals the dynamic of NMD factors in
P-bodies . . . . . . . . . . . . . . . . 1145
David K. Hwang and
Steven M. Claypool and
Danielle Leuenberger and
Heather L. Tienson and
Carla M. Koehler Tim54p connects inner membrane assembly
and proteolytic pathways in the
mitochondrion . . . . . . . . . . . . . 1161
Morgan B. Goulding and
Julie C. Canman and
Eric N. Senning and
Andrew H. Marcus and
Bruce Bowerman Control of nuclear centration in the
\bionameC. elegans zygote by
receptor-independent G$ \alpha $
signaling and myosin II . . . . . . . . 1177
Brian D. Dunn and
Takeshi Sakamoto and
Myoung-Soon S. Hong and
James R. Sellers and
Peter A. Takizawa Myo4p is a monomeric myosin with
motility uniquely adapted to transport
mRNA . . . . . . . . . . . . . . . . . . 1193
Patricia T. Yam and
Cyrus A. Wilson and
Lin Ji and
Benedict Hebert and
Erin L. Barnhart and
Natalie A. Dye and
Paul W. Wiseman and
Gaudenz Danuser and
Julie A. Theriot Actin--myosin network reorganization
breaks symmetry at the cell rear to
spontaneously initiate polarized cell
motility . . . . . . . . . . . . . . . . 1207
Leila Wyatt and
Carol Wadham and
Lesley A. Crocker and
Michael Lardelli and
Yeesim Khew-Goodall The protein tyrosine phosphatase Pez
regulates TGF$ \beta $,
epithelial--mesenchymal transition, and
organ development . . . . . . . . . . . 1223
Sophie Zisman and
Karen Marom and
Oshri Avraham and
Lilah Rinsky-Halivni and
Uri Gai and
Gilit Kligun and
Vered Tzarfaty-Majar and
Tatsuo Suzuki and
Avihu Klar Proteolysis and membrane capture of
F-spondin generates combinatorial
guidance cues from a single molecule . . 1237
Voytek Okreglak and
David G. Drubin Cofilin recruitment and function during
actin-mediated endocytosis dictated by
actin nucleotide state . . . . . . . . . 1251
Neal M. Alto and
Andrew W. Weflen and
Matthew J. Rardin and
Defne Yarar and
Cheri S. Lazar and
Raffi Tonikian and
Antonius Koller and
Susan S. Taylor and
Charles Boone and
Sachdev S. Sidhu and
Sandra L. Schmid and
Gail A. Hecht and
Jack E. Dixon The type III effector EspF coordinates
membrane trafficking by the
spatiotemporal activation of two
eukaryotic signaling pathways . . . . . 1265
Jaap D. van Buul and
Michael J. Allingham and
Thomas Samson and
Julia Meller and
Etienne Boulter and
Rafael García-Mata and
Keith Burridge RhoG regulates endothelial apical cup
assembly downstream from ICAM1
engagement and is involved in leukocyte
trans-endothelial migration . . . . . . 1279
Caroline Bourgin and
Keith K. Murai and
Melanie Richter and
Elena B. Pasquale The EphA4 receptor regulates dendritic
spine remodeling by affecting $ \beta
$1-integrin signaling pathways . . . . . 1295
Anjon Audhya and
Arshad Desai and
Karen Oegema A role for Rab5 in structuring the
endoplasmic reticulum . . . . . . . . . 1309
Ruth Williams Tension testing in adherent cells . . . ??
Ruth Williams mRNAs sit out the stress in EGP bodies ??
Ruth Williams Nucleator or not? . . . . . . . . . . . ??
Ruth Williams Calcium channels SMA . . . . . . . . . . ??
Ruth Williams How Ire1 senses stress . . . . . . . . . ??
Nicole LeBrasseur MHC and antigen in exosomes . . . . . . ??
Nicole LeBrasseur Proteins on the edge of stability . . . ??
Nicole LeBrasseur Special skin cells get pigments . . . . ??
Nicole LeBrasseur Nervous blood cells . . . . . . . . . . ??
Nicole LeBrasseur Apoptosis prevents osteoporosis . . . . ??
Ruth Williams Roger Tsien: Bringing color to cell
biology . . . . . . . . . . . . . . . . 6
Emma Hill JCB content automatically deposited in
PubMed Central (PMC) . . . . . . . . . . 9
Tim P. Levine A lipid transfer protein that transfers
lipid . . . . . . . . . . . . . . . . . 11
Claudia Couwenbergs and
Jean-Claude Labbé and
Morgan Goulding and
Thomas Marty and
Bruce Bowerman and
Monica Gotta Heterotrimeric G protein signaling
functions with dynein to promote spindle
positioning in \bionameC. elegans . . . 15
Zhenyi Ma and
David P. Myers and
Ru Feng Wu and
Fiemu E. Nwariaku and
Lance S. Terada p66$^{\rm Shc}$ mediates anoikis through
RhoA . . . . . . . . . . . . . . . . . . 23
Roberta Palumbo and
Beatriz G. Galvez and
Tobias Pusterla and
Francesco De Marchis and
Giulio Cossu and
Kenneth B. Marcu and
Marco E. Bianchi Cells migrating to sites of tissue
damage in response to the danger signal
HMGB1 require NF-$ \kappa $B activation 33
Seung-Hwan Kim and
Antonia H. Holway and
Suzanne Wolff and
Andrew Dillin and
W. Matthew Michael SMK-1\slash PPH-4.1-mediated silencing
of the CHK-1 response to DNA damage in
early \bionameC. elegans embryos . . . . 41
Makoto Otsuki and
Masayuki Seki and
Eri Inoue and
Akari Yoshimura and
Genta Kato and
Saki Yamanouchi and
Yoh-ichi Kawabe and
Shusuke Tada and
Akira Shinohara and
Jun-ichiro Komura and
Tetsuya Ono and
Shunichi Takeda and
Yutaka Ishii and
Takemi Enomoto Functional interactions between BLM and
XRCC3 in the cell . . . . . . . . . . . 53
Nathaniel P. Hoyle and
Lydia M. Castelli and
Susan G. Campbell and
Leah E. A. Holmes and
Mark P. Ashe Stress-dependent relocalization of
translationally primed mRNPs to
cytoplasmic granules that are
kinetically and spatially distinct from
P-bodies . . . . . . . . . . . . . . . . 65
Yukio Kimata and
Yuki Ishiwata-Kimata and
Tatsuhiko Ito and
Aiko Hirata and
Tomohide Suzuki and
Daisuke Oikawa and
Masato Takeuchi and
Kenji Kohno Two regulatory steps of ER-stress sensor
Ire1 involving its cluster formation and
interaction with unfolded proteins . . . 75
Umesh K. Bageshwar and
Siegfried M. Musser Two electrical potential-dependent steps
are required for transport by the
\bionameEscherichia coli Tat machinery 87
David Halter and
Sylvia Neumann and
Suzanne M. van Dijk and
Jasja Wolthoorn and
Ann M. de Mazi\`ere and
Otilia V. Vieira and
Peter Mattjus and
Judith Klumperman and
Gerrit van Meer and
Hein Sprong Pre- and post-Golgi translocation of
glucosylceramide in glycosphingolipid
synthesis . . . . . . . . . . . . . . . 101
Margot E. Quinlan and
Susanne Hilgert and
Anaid Bedrossian and
R. Dyche Mullins and
Eugen Kerkhoff Regulatory interactions between two
actin nucleators, Spire and Cappuccino 117
Luguo Sun and
Kewei Ma and
Haixia Wang and
Fang Xiao and
Yan Gao and
Wei Zhang and
Kepeng Wang and
Xiang Gao and
Nancy Ip and
Zhenguo Wu JAK1--STAT1--STAT3, a key pathway
promoting proliferation and preventing
premature differentiation of myoblasts 129
Sibylle Jablonka and
Marcus Beck and
Barbara Dorothea Lechner and
Christine Mayer and
Michael Sendtner Defective Ca$^{2+}$ channel clustering
in axon terminals disturbs excitability
in motoneurons in spinal muscular
atrophy . . . . . . . . . . . . . . . . 139
Olav Olsen and
Lars Funke and
Jia-fu Long and
Masaki Fukata and
Toshinari Kazuta and
Jonathan C. Trinidad and
Kimberly A. Moore and
Hidemi Misawa and
Paul A. Welling and
Alma L. Burlingame and
Mingjie Zhang and
David S. Bredt Renal defects associated with improper
polarization of the CRB and DLG polarity
complexes in MALS-3 knockout mice . . . 151
M\`onica Suelves and
Berta Vidal and
Antonio L. Serrano and
Marc Tjwa and
Josep Roma and
Roser López-Alemany and
Aernout Luttun and
María Martínez de Lagrán and
\`Angels Díaz-Ramos and
Merc\`e Jardí and
Manuel Roig and
Mara Dierssen and
Mieke Dewerchin and
Peter Carmeliet and
Pura Muñoz-Cánoves uPA deficiency exacerbates muscular
dystrophy in MDX mice . . . . . . . . . 165
Chandra L. Kilburn and
Chad G. Pearson and
Edwin P. Romijn and
Janet B. Meehl and
Thomas H. Giddings and
Brady P. Culver and
John R. Yates and
Mark Winey New \bionameTetrahymena basal body
protein components identify basal body
domain structure . . . . . . . . . . . . 167
Mitch Leslie A chromatin twist to silencing choice ??
Mitch Leslie A receptor with divided loyalties . . . ??
Mitch Leslie RNA polymerase on the clock . . . . . . ??
Mitch Leslie Filopodia motor ahead . . . . . . . . . ??
Mitch Leslie New mRNA modification? . . . . . . . . . ??
Richard Robinson Red blood cells have a killer touch . . ??
Richard Robinson Enzyme may link inflammation to new cell
fate . . . . . . . . . . . . . . . . . . ??
Richard Robinson Forward walk with a random twist . . . . ??
Richard Robinson Hand it to the nucleolus . . . . . . . . ??
Richard Robinson Nucleus runs ahead of centrosome . . . . ??
Nicole LeBrasseur Junying Yuan: Changing avenues without
losing focus . . . . . . . . . . . . . . 174
Mike Rossner Bending the Truth with a PRISM . . . . . 177
Duane A. Compton Chromosome orientation . . . . . . . . . 179
Eric Weterings and
David J. Chen DNA-dependent protein kinase in
nonhomologous end joining: a lock with
multiple keys? . . . . . . . . . . . . . 183
Iain M. Porter and
Sarah E. McClelland and
Guennadi A. Khoudoli and
Christopher J. Hunter and
Jens S. Andersen and
Andrew D. McAinsh and
J. Julian Blow and
Jason R. Swedlow Bod1, a novel kinetochore protein
required for chromosome biorientation 187
Noélia Custódio and
Maria Vivo and
Michael Antoniou and
Maria Carmo-Fonseca Splicing- and cleavage-independent
requirement of RNA polymerase II CTD for
mRNA release from the transcription site 199
Kai Michelsen and
Volker Schmid and
Jutta Metz and
Katja Heusser and
Urban Liebel and
Torsten Schwede and
Anne Spang and
Blanche Schwappach Novel cargo-binding site in the $ \beta
$ and $ \delta $ subunits of coatomer 209
Hanh T. Nguyen and
Francesca Voza and
Nader Ezzeddine and
Manfred Frasch Drosophila mind bomb2 is required for
maintaining muscle integrity and
survival . . . . . . . . . . . . . . . . 219
Hiroshi Tokuo and
Katsuhide Mabuchi and
Mitsuo Ikebe The motor activity of myosin--X promotes
actin fiber convergence at the cell
periphery to initiate filopodia
formation . . . . . . . . . . . . . . . 229
Chun Xiang Sun and
Marco A. O. Magalhães and
Michael Glogauer Rac1 and Rac2 differentially regulate
actin free barbed end formation
downstream of the fMLP receptor . . . . 239
Angela Glading and
Jaewon Han and
Rebecca A. Stockton and
Mark H. Ginsberg KRIT-1\slash CCM1 is a Rap1 effector
that regulates endothelial cell--cell
junctions . . . . . . . . . . . . . . . 247
Karthik Jeganathan and
Liviu Malureanu and
Darren J. Baker and
Susan C. Abraham and
Jan M. van Deursen Bub1 mediates cell death in response to
chromosome missegregation and acts to
suppress spontaneous tumorigenesis . . . 255
Mary Kate Alexander and
Susanna Mlynarczyk-Evans and
Morgan Royce-Tolland and
Alex Plocik and
Sundeep Kalantry and
Terry Magnuson and
Barbara Panning Differences between homologous alleles
of olfactory receptor genes require the
Polycomb Group protein Eed . . . . . . . 269
Irene Siegl-Cachedenier and
Ignacio Flores and
Peter Klatt and
Maria A. Blasco Telomerase reverses epidermal hair
follicle stem cell defects and loss of
long-term survival associated with
critically short telomeres . . . . . . . 277
Stéphanie Boireau and
Paolo Maiuri and
Eugenia Basyuk and
Manuel de la Mata and
Anna Knezevich and
Bérang\`ere Pradet-Balade and
Volker Bäcker and
Alberto Kornblihtt and
Alessandro Marcello and
Edouard Bertrand The transcriptional cycle of HIV-1 in
real-time and live cells . . . . . . . . 291
Daniela Deponti and
Stéphanie François and
Silvia Baesso and
Clara Sciorati and
Anna Innocenzi and
Vania Broccoli and
Françoise Muscatelli and
Raffaella Meneveri and
Emilio Clementi and
Giulio Cossu and
Silvia Brunelli Necdin mediates skeletal muscle
regeneration by promoting myoblast
survival and differentiation . . . . . . 305
Susanne Graser and
York-Dieter Stierhof and
Sébastien B. Lavoie and
Oliver S. Gassner and
Stefan Lamla and
Mikael Le Clech and
Erich A. Nigg Cep164, a novel centriole appendage
protein required for primary cilium
formation . . . . . . . . . . . . . . . 321
Hannes Schmidt and
Agne Stonkute and
René Jüttner and
Susanne Schäffer and
Jens Buttgereit and
Robert Feil and
Franz Hofmann and
Fritz G. Rathjen The receptor guanylyl cyclase Npr2 is
essential for sensory axon bifurcation
within the spinal cord . . . . . . . . . 331
Patrick Lajoie and
Emily A. Partridge and
Ginette Guay and
Jacky G. Goetz and
Judy Pawling and
Annick Lagana and
Bharat Joshi and
James W. Dennis and
Ivan R. Nabi Plasma membrane domain organization
regulates EGFR signaling in tumor cells 341
Jiayin Zhang and
Sana Ahmad and
Yinghui Mao BubR1 and APC/EB1 cooperate to maintain
metaphase chromosome alignment . . . . . 357
Ruth Williams Clean up or go crazy . . . . . . . . . . ??
Ruth Williams Putting ER in its place . . . . . . . . ??
Ruth Williams A polarity/proton loop . . . . . . . . . ??
Ruth Williams Constructing P-bodies . . . . . . . . . ??
Ruth Williams Heart hormone release . . . . . . . . . ??
Caitlin Sedwick Imaging the immune response . . . . . . ??
Caitlin Sedwick Tumors' accomplices in invasion . . . . ??
Caitlin Sedwick Structure of the meiotic spindle . . . . ??
Caitlin Sedwick Localized mRNA is the norm . . . . . . . ??
Caitlin Sedwick Cholesterol and Alzheimer's . . . . . . ??
Nicole LeBrasseur Hidde Ploegh: Immunologist, journeyman 364
Fumio Motegi and
Geraldine Seydoux Revisiting the role of microtubules in
\bionameC. elegans polarity . . . . . . 367
Christopher C. Glembotski Getting a G--RRP on regulated exocytosis
in the heart . . . . . . . . . . . . . . 371
Dominique Vercammen and
Wim Declercq and
Peter Vandenabeele and
Frank Van Breusegem Are metacaspases caspases? . . . . . . . 375
Matthew T. Cabeen and
Christine Jacobs-Wagner Skin and bones: the bacterial
cytoskeleton, cell wall, and cell
morphogenesis . . . . . . . . . . . . . 381
Karl Bihlmaier and
Nikola Mesecke and
Nadia Terziyska and
Melanie Bien and
Kai Hell and
Johannes M. Herrmann The disulfide relay system of
mitochondria is connected to the
respiratory chain . . . . . . . . . . . 389
Miao-Chih Tsai and
Julie Ahringer Microtubules are involved in
anterior-posterior axis formation in
\bionameC. elegans embryos . . . . . . . 397
Christian Frantz and
Anastasios Karydis and
Perihan Nalbant and
Klaus M. Hahn and
Diane L. Barber Positive feedback between Cdc42 activity
and H$^+$ efflux by the Na--H exchanger
NHE1 for polarity of migrating cells . . 403
Junjie Lu and
David M. Gilbert Proliferation-dependent and cell
cycle--regulated transcription of mouse
pericentric heterochromatin . . . . . . 411
Hiromi Maekawa and
Claire Priest and
Johannes Lechner and
Gislene Pereira and
Elmar Schiebel The yeast centrosome translates the
positional information of the anaphase
spindle into a cell cycle signal . . . . 423
Carolyn J. Decker and
Daniela Teixeira and
Roy Parker Edc3p and a glutamine/asparagine-rich
domain of Lsm4p function in processing
body assembly in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 437
Sebastian Petri and
Matthias Grimmler and
Sabine Over and
Utz Fischer and
Oliver J. Gruss Dephosphorylation of survival motor
neurons (SMN) by PPM1G/PP2C$ \gamma $
governs Cajal body localization and
stability of the SMN complex . . . . . . 451
Christopher J. R. Loewen and
Barry P. Young and
Shabnam Tavassoli and
Timothy P. Levine Inheritance of cortical ER in yeast is
required for normal septin organization 467
Maria Filimonenko and
Susanne Stuffers and
Camilla Raiborg and
Ai Yamamoto and
Lene Maleròd and
Elizabeth M. C. Fisher and
Adrian Isaacs and
Andreas Brech and
Harald Stenmark and
Anne Simonsen Functional multivesicular bodies are
required for autophagic clearance of
protein aggregates associated with
neurodegenerative disease . . . . . . . 485
Kaiyao Huang and
Dennis R. Diener and
Aaron Mitchell and
Gregory J. Pazour and
George B. Witman and
Joel L. Rosenbaum Function and dynamics of PKD2 in
Chlamydomonas reinhardtii flagella . . . 501
Erin E. Dymek and
Elizabeth F. Smith A conserved CaM- and radial
spoke--associated complex mediates
regulation of flagellar dynein activity 515
Igor I. Rybkin and
Mi-Sung Kim and
Svetlana Bezprozvannaya and
Xiaoxia Qi and
James A. Richardson and
Craig F. Plato and
Joseph A. Hill and
Rhonda Bassel-Duby and
Eric N. Olson Regulation of atrial natriuretic peptide
secretion by a novel Ras-like protein 527
Jinhong Huang and
Asako Furuya and
Teiichi Furuichi Very-KIND, a KIND domain--containing
RasGEF, controls dendrite growth by
linking Ras small GTPases and MAP2 . . . 539
Panagiotis Flevaris and
Aleksandra Stojanovic and
Haixia Gong and
Athar Chishti and
Emily Welch and
Xiaoping Du A molecular switch that controls cell
spreading and retraction . . . . . . . . 553
Mitch Leslie Sizing the nucleus just right . . . . . ??
Mitch Leslie Healing skin from within . . . . . . . . ??
Mitch Leslie Fusion in three easy steps . . . . . . . ??
Mitch Leslie When cargos jump tracks . . . . . . . . ??
Mitch Leslie Cancer cells straighten out . . . . . . ??
Nicole LeBrasseur Actin mesh hinders microtubules . . . . ??
Nicole LeBrasseur Promoters enter plant--pathogen fray . . ??
Nicole LeBrasseur Turning motor into anchor . . . . . . . ??
Nicole LeBrasseur Protein shields for dehydration . . . . ??
Nicole LeBrasseur New nucleator for actin . . . . . . . . ??
Caitlin Sedwick Elizabeth Miller: Sleuthing the details
of the secretory pathway . . . . . . . . 572
Roger D. Sloboda and
Joel L. Rosenbaum Making sense of cilia and flagella . . . 575
Michael D. Huber and
Larry Gerace The size-wise nucleus: nuclear volume
control in eukaryotes . . . . . . . . . 583
Stephan Kutik and
Bernard Guiard and
Helmut E. Meyer and
Nils Wiedemann and
Nikolaus Pfanner Cooperation of translocase complexes in
mitochondrial protein import . . . . . . 585
Frank R. Neumann and
Paul Nurse Nuclear size control in fission yeast 593
Emilie Montembault and
Stéphanie Dutertre and
Claude Prigent and
Régis Giet PRP4 is a spindle assembly checkpoint
protein required for MPS1, MAD1, and
MAD2 localization to the kinetochores 601
Oi Kwan Wong and
Guowei Fang Cdk1 phosphorylation of BubR1 controls
spindle checkpoint arrest and
Plk1-mediated formation of the 3F3/2
epitope . . . . . . . . . . . . . . . . 611
Caroline H. Yi and
Dodzie K. Sogah and
Michael Boyce and
Alexei Degterev and
Dana E. Christofferson and
Junying Yuan A genome-wide RNAi screen reveals
multiple regulators of caspase
activation . . . . . . . . . . . . . . . 619
Anna V. Shnyrova and
Juan Ayllon and
Ilya I. Mikhalyov and
Enrique Villar and
Joshua Zimmerberg and
Vadim A. Frolov Vesicle formation by self-assembly of
membrane-bound matrix proteins into a
fluidlike budding domain . . . . . . . . 627
Boris M. Slepchenko and
Irina Semenova and
Ilya Zaliapin and
Vladimir Rodionov Switching of membrane organelles between
cytoskeletal transport systems is
determined by regulation of the
microtubule-based transport . . . . . . 635
Enbo Liu and
Alan Yueh-Luen Lee and
Takuya Chiba and
Erin Olson and
Peiqing Sun and
Xiaohua Wu The ATR-mediated S phase checkpoint
prevents rereplication in mammalian
cells when licensing control is
disrupted . . . . . . . . . . . . . . . 643
Patricia Melloy and
Shu Shen and
Erin White and
J. Richard McIntosh and
Mark D. Rose Nuclear fusion during yeast mating
occurs by a three-step pathway . . . . . 659
Dimitrios A. Skoufias and
Rose-Laure Indorato and
Françoise Lacroix and
Andreas Panopoulos and
Robert L. Margolis Mitosis persists in the absence of Cdk1
activity when proteolysis or protein
phosphatase activity is suppressed . . . 671
Debabrata Patra and
Xiaoyun Xing and
Sherri Davies and
Jennifer Bryan and
Carl Franz and
Ernst B. Hunziker and
Linda J. Sandell Site-1 protease is essential for
endochondral bone formation in mice . . 687
Bernhard Gillissen and
Frank Essmann and
Philipp G. Hemmati and
Antje Richter and
Anja Richter and
Ilker Öztop and
Govindaswamy Chinnadurai and
Bernd Dörken and
Peter T. Daniel Mcl-1 determines the Bax dependency of
Nbk/Bik-induced apoptosis . . . . . . . 701
Tania Habib and
Heon Park and
Mark Tsang and
Ignacio Moreno de Alborán and
Andrea Nicks and
Leslie Wilson and
Paul S. Knoepfler and
Sarah Andrews and
David J. Rawlings and
Robert N. Eisenman and
Brian M. Iritani Myc stimulates B lymphocyte
differentiation and amplifies calcium
signaling . . . . . . . . . . . . . . . 717
Tal Ilani and
Chand Khanna and
Ming Zhou and
Timothy D. Veenstra and
Anthony Bretscher Immune synapse formation requires ZAP-70
recruitment by ezrin and CD43 removal by
moesin . . . . . . . . . . . . . . . . . 733
Angelika Kümin and
Matthias Schäfer and
Nikolas Epp and
Philippe Bugnon and
Christiane Born-Berclaz and
Annette Oxenius and
Anke Klippel and
Wilhelm Bloch and
Sabine Werner Peroxiredoxin 6 is required for blood
vessel integrity in wounded skin . . . . 747
Craig Furman and
Alisha L. Sieminski and
Adam V. Kwiatkowski and
Douglas A. Rubinson and
Eliza Vasile and
Roderick T. Bronson and
Reinhard Fässler and
Frank B. Gertler Ena\slash VASP is required for
endothelial barrier function in vivo . . 761
Mazen Sidani and
Deborah Wessels and
Ghassan Mouneimne and
Mousumi Ghosh and
Sumanta Goswami and
Corina Sarmiento and
Weigang Wang and
Spencer Kuhl and
Mirvat El-Sibai and
Jonathan M. Backer and
Robert Eddy and
David Soll and
John Condeelis Cofilin determines the migration
behavior and turning frequency of
metastatic cancer cells . . . . . . . . 777
Petra Baumgärtner and
Margarethe Geiger and
Susanne Zieseniss and
Julia Malleier and
James A. Huntington and
Karin Hochrainer and
Edith Bielek and
Mechthild Stoeckelhuber and
Kirsten Lauber and
Dag Scherfeld and
Petra Schwille and
Katja Wäldele and
Klaus Beyer and
Bernd Engelmann Phosphatidylethanolamine critically
supports internalization of
cell-penetrating protein C inhibitor . . 793
Nicole LeBrasseur Apoptotic inaccessibility with maturity ??
Nicole LeBrasseur ParM pushes plasmids apart . . . . . . . ??
Nicole LeBrasseur Chromosomes leave envelope for karyosome ??
Nicole LeBrasseur Peptidase frees receptors in endosomes ??
Nicole LeBrasseur Slow-moving Alzheimer's . . . . . . . . ??
Mitch Leslie Embryonic telomeres go long . . . . . . ??
Mitch Leslie Unique tasks for ribosomal paralogues ??
Mitch Leslie Blinded by old macrophages . . . . . . . ??
Mitch Leslie RNA polymerase caught loitering . . . . ??
Mitch Leslie Time to split . . . . . . . . . . . . . ??
Caitlin Sedwick Stefan Westermann: a close look at
kinetochore function . . . . . . . . . . 810
Jakob Mòller-Jensen and
Kenn Gerdes Plasmid segregation: spatial awareness
at the molecular level . . . . . . . . . 813
Oscar M. Lancaster and
C. Fiona Cullen and
Hiroyuki Ohkura NHK-1 phosphorylates BAF to allow
karyosome formation in the
\bionameDrosophila oocyte nucleus . . . 817
Kevin M. Wright and
Michelle I. Smith and
Lila Farrag and
Mohanish Deshmukh Chromatin modification of Apaf-1
restricts the apoptotic pathway in
mature neurons . . . . . . . . . . . . . 825
Taeck J. Jeon and
Dai-Jen Lee and
Susan Lee and
Gerald Weeks and
Richard A. Firtel Regulation of Rap1 activity by RapGAP1
controls cell adhesion at the front of
chemotaxing cells . . . . . . . . . . . 833
Jennifer M. Bupp and
Adriana E. Martin and
Elizabeth S. Stensrud and
Sue L. Jaspersen Telomere anchoring at the nuclear
periphery requires the budding yeast
Sad1-UNC-84 domain protein Mps3 . . . . 845
Martina Stagno D'Alcontres and
Aaron Mendez-Bermudez and
Jennifer L. Foxon and
Nicola J. Royle and
Paolo Salomoni Lack of TRF2 in ALT cells causes
PML-dependent p53 activation and loss of
telomeric DNA . . . . . . . . . . . . . 855
Linda Wordeman and
Michael Wagenbach and
George von Dassow MCAK facilitates chromosome movement by
promoting kinetochore microtubule
turnover . . . . . . . . . . . . . . . . 869
Diana Stojanovski and
Bernard Guiard and
Vera Kozjak-Pavlovic and
Nikolaus Pfanner and
Chris Meisinger Alternative function for the
mitochondrial SAM complex in biogenesis
of $ \alpha $-helical TOM proteins . . . 881
Maija Puhka and
Helena Vihinen and
Merja Joensuu and
Eija Jokitalo Endoplasmic reticulum remains continuous
and undergoes sheet-to-tubule
transformation during cell division in
mammalian cells . . . . . . . . . . . . 895
Chet E. Holterman and
Fabien Le Grand and
Shihuan Kuang and
Patrick Seale and
Michael A. Rudnicki Megf10 regulates the progression of the
satellite cell myogenic program . . . . 911
Nikhil deSouza and
Jie Cui and
Miroslav Dura and
Thomas V. McDonald and
Andrew R. Marks A function for tyrosine phosphorylation
of type 1 inositol 1,4,5-trisphosphate
receptor in lymphocyte activation . . . 923
K. G. Suresh Kumar and
Hervé Barriere and
Christopher J. Carbone and
Jianghuai Liu and
Gayathri Swaminathan and
Ping Xu and
Ying Li and
Darren P. Baker and
Junmin Peng and
Gergely L. Lukacs and
Serge Y. Fuchs Site-specific ubiquitination exposes a
linear motif to promote interferon-$
\alpha $ receptor endocytosis . . . . . 935
Jinoh Kim and
Bertrand Kleizen and
Regina Choy and
Gopal Thinakaran and
Sangram S. Sisodia and
Randy W. Schekman Biogenesis of $ \gamma $-secretase early
in the secretory pathway . . . . . . . . 951
Ankur H. Shah and
Nicholas L. Cianciola and
Jeffrey L. Mills and
Frank D. Sönnichsen and
Cathleen Carlin Adenovirus RID$ \alpha $ regulates
endosome maturation by mimicking
GTP--Rab7 . . . . . . . . . . . . . . . 965
Benjamin E. Padilla and
Graeme S. Cottrell and
Dirk Roosterman and
Stella Pikios and
Laurent Muller and
Martin Steinhoff and
Nigel W. Bunnett Endothelin-converting enzyme-1 regulates
endosomal sorting of calcitonin
receptor-like receptor and $ \beta
$-arrestins . . . . . . . . . . . . . . 981
Leontine L. Galante and
Jean E. Schwarzbauer Requirements for sulfate transport and
the diastrophic dysplasia sulfate
transporter in fibronectin matrix
assembly . . . . . . . . . . . . . . . . 999
Fumihiko Nakamura and
Teresia M. Osborn and
Christopher A. Hartemink and
John H. Hartwig and
Thomas P. Stossel Structural basis of filamin A functions 1011
Tsuyoshi Morita and
Taira Mayanagi and
Kenji Sobue Dual roles of myocardin-related
transcription factors in
epithelial--mesenchymal transition via
slug induction and actin remodeling . . 1027
Jonathan D. Humphries and
Pengbo Wang and
Charles Streuli and
Benny Geiger and
Martin J. Humphries and
Christoph Ballestrem Vinculin controls focal adhesion
formation by direct interactions with
talin and actin . . . . . . . . . . . . 1043
Christopher S. Campbell and
R. Dyche Mullins In vivo visualization of type II plasmid
segregation: bacterial actin filaments
pushing plasmids . . . . . . . . . . . . 1059
Valeria R. Caiolfa and
Moreno Zamai and
Gabriele Malengo and
Annapaola Andolfo and
Chris D. Madsen and
Jason Sutin and
Michelle A. Digman and
Enrico Gratton and
Francesco Blasi and
Nicolai Sidenius Monomer--dimer dynamics and distribution
of GPI-anchored uPAR are determined by
cell surface protein assemblies . . . . 1067
Mitch Leslie A lean and mean VEGF for cancer cells ??
Mitch Leslie Microglia to the rescue . . . . . . . . ??
Mitch Leslie Hey, DNA, get over here . . . . . . . . ??
Mitch Leslie For long, lush cilia, try Par3 . . . . . ??
Mitch Leslie Making room for muscle . . . . . . . . . ??
Richard Robinson Minor spliceosome, major surprise: it's
cytoplasmic . . . . . . . . . . . . . . ??
Richard Robinson A chewing proteasome is stabilized . . . ??
Richard Robinson Misfolding in muscle when neuron
misfires . . . . . . . . . . . . . . . . ??
Richard Robinson Myosin remains strong as muscle
contracts . . . . . . . . . . . . . . . ??
Ruth Williams Gilbert Weidinger: Regeneration
researcher . . . . . . . . . . . . . . . 1088
Mike Rossner and
Heather Van Epps and
Emma Hill Show me the data . . . . . . . . . . . . 1091
Maria Carmo-Fonseca How genes find their way inside the cell
nucleus . . . . . . . . . . . . . . . . 1093
Miroslav Dundr and
Jason K. Ospina and
Myong-Hee Sung and
Sam John and
Madhvi Upender and
Thomas Ried and
Gordon L. Hager and
A. Gregory Matera Actin-dependent intranuclear
repositioning of an active gene locus in
vivo . . . . . . . . . . . . . . . . . . 1095
Savraj S. Grewal and
Justin R. Evans and
Bruce A. Edgar Drosophila TIF--IA is required for
ribosome synthesis and cell growth and
is regulated by the TOR pathway . . . . 1105
Nils Wiedemann and
Martin van der Laan and
Dana P. Hutu and
Peter Rehling and
Nikolaus Pfanner Sorting switch of mitochondrial
presequence translocase involves
coupling of motor module to respiratory
chain . . . . . . . . . . . . . . . . . 1115
Carine Bossard and
Damien Bresson and
Roman S. Polishchuk and
Vivek Malhotra Dimeric PKD regulates membrane fission
to form transport carriers at the TGN 1123
Jeff Sfakianos and
Akashi Togawa and
Sandra Maday and
Mike Hull and
Marc Pypaert and
Lloyd Cantley and
Derek Toomre and
Ira Mellman Par3 functions in the biogenesis of the
primary cilium in polarized epithelial
cells . . . . . . . . . . . . . . . . . 1133
Kit Wong and
Alexandra Van Keymeulen and
Henry R. Bourne PDZRhoGEF and myosin II localize RhoA
activity to the back of polarizing
neutrophil-like cells . . . . . . . . . 1141
Kumiko Oishi and
Hideyuki Okano and
Hitoshi Sawa RMD-1, a novel microtubule-associated
protein, functions in chromosome
segregation in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 1149
Jennifer Q. Kwong and
Matthew S. Henning and
Anatoly A. Starkov and
Giovanni Manfredi The mitochondrial respiratory chain is a
modulator of apoptosis . . . . . . . . . 1163
Anna Shestakova and
Elena Suvorova and
Oleksandra Pavliv and
Galimat Khaidakova and
Vladimir Lupashin Interaction of the conserved oligomeric
Golgi complex with t--SNARE
Syntaxin5a/Sed5 enhances intra-Golgi
SNARE complex stability . . . . . . . . 1179
Irina Raykhel and
Heli Alanen and
Kirsi Salo and
Jaana Jurvansuu and
Van Dat Nguyen and
Maria Latva-Ranta and
Lloyd Ruddock A molecular specificity code for the
three mammalian KDEL receptors . . . . . 1193
Enrique Lara-Pezzi and
Nadine Winn and
Angelika Paul and
Karl McCullagh and
Esfir Slominsky and
Maria Paola Santini and
Foteini Mourkioti and
Padmini Sarathchandra and
Satsuki Fukushima and
Ken Suzuki and
Nadia Rosenthal A naturally occurring calcineurin
variant inhibits FoxO activity and
enhances skeletal muscle regeneration 1205
Jihong Kang and
Serge Rivest MyD88-deficient bone marrow cells
accelerate onset and reduce survival in
a mouse model of amyotrophic lateral
sclerosis . . . . . . . . . . . . . . . 1219
Beata Jablonska and
Adan Aguirre and
Renaud Vandenbosch and
Shibeshih Belachew and
Cyril Berthet and
Philipp Kaldis and
Vittorio Gallo Cdk2 is critical for proliferation and
self-renewal of neural progenitor cells
in the adult subventricular zone . . . . 1231
Jacco van Rheenen and
Xiaoyan Song and
Wies van Roosmalen and
Michael Cammer and
Xiaoming Chen and
Vera DesMarais and
Shu-Chin Yip and
Jonathan M. Backer and
Robert J. Eddy and
John S. Condeelis EGF-induced PIP$_2$ hydrolysis releases
and activates cofilin locally in
carcinoma cells . . . . . . . . . . . . 1247
Pierre Mineur and
Alain C. Colige and
Christophe. F. Deroanne and
Johanne Dubail and
Frédéric Kesteloot and
Yvette Habraken and
Agn\`es Noël and
Stefan Vöö and
Johannes Waltenberger and
Charles M. Lapi\`ere and
Betty V. Nusgens and
Charles A. Lambert Newly identified biologically active and
proteolysis-resistant VEGF--A isoform
VEGF111 is induced by genotoxic agents 1261
Katherine A. Owen and
Fiona J. Pixley and
Keena S. Thomas and
Miguel Vicente-Manzanares and
Brianne J. Ray and
Alan F. Horwitz and
J. Thomas Parsons and
Hilary E. Beggs and
E. Richard Stanley and
Amy H. Bouton Regulation of lamellipodial persistence,
adhesion turnover, and motility in
macrophages by focal adhesion kinase . . 1275
Hiroshi Kohsaka and
Etsuko Takasu and
Akinao Nose In vivo induction of postsynaptic
molecular assembly by the cell adhesion
molecule Fasciclin2 . . . . . . . . . . 1289
Joell L. Solan and
Lucrecia Marquez-Rosado and
Paul L. Sorgen and
Perry J. Thornton and
Philip R. Gafken and
Paul D. Lampe Phosphorylation at S365 is a gatekeeper
event that changes the structure of Cx43
and prevents down-regulation by PKC . . 1301
Pierre-Jean Wipff and
Daniel B. Rifkin and
Jean-Jacques Meister and
Boris Hinz Myofibroblast contraction activates
latent TGF-$ \beta $1 from the
extracellular matrix . . . . . . . . . . 1311
Nicole LeBrasseur Acrobatic flexibility of the translocon ??
Nicole LeBrasseur To bud where no bud has gone before . . ??
Nicole LeBrasseur Motility without invasion . . . . . . . ??
Nicole LeBrasseur Translation turns on dendritic cells . . ??
Richard Robinson Cells within cells (within cells) . . . ??
Richard Robinson The NPC, in detail . . . . . . . . . . . ??
Richard Robinson tRNA's Los is a gain after damage . . . ??
Richard Robinson Building the immunological bull's eye ??
Richard Robinson Lipid + Alzheimer's plaque = problem . . ??
Ruth Williams Anthony Hyman: From unlikely scientist
to Royal Society Fellow . . . . . . . . 1330
William R. Skach The expanding role of the ER translocon
in membrane protein folding . . . . . . 1333
Stine Jòrgensen and
Ingegerd Elvers and
Morten Beck Trelle and
Tobias Menzel and
Morten Eskildsen and
Ole Nòrregaard Jensen and
Thomas Helleday and
Kristian Helin and
Claus Storgaard Sòrensen The histone methyltransferase SET8 is
required for S-phase progression . . . . 1337
Akatsuki Kimura and
Shuichi Onami Local cortical pulling-force repression
switches centrosomal centration and
posterior displacement in \bionameC.
elegans . . . . . . . . . . . . . . . . 1347
Hidenori Otera and
Yohsuke Taira and
Chika Horie and
Yurina Suzuki and
Hiroyuki Suzuki and
Kiyoko Setoguchi and
Hiroki Kato and
Toshihiko Oka and
Katsuyoshi Mihara A novel insertion pathway of
mitochondrial outer membrane proteins
with multiple transmembrane segments . . 1355
Michael D. Blower and
Elma Feric and
Karsten Weis and
Rebecca Heald Genome-wide analysis demonstrates
conserved localization of messenger RNAs
to mitotic microtubules . . . . . . . . 1365
Zongtian Tong and
Xiang-Dong Gao and
Audrey S. Howell and
Indrani Bose and
Daniel J. Lew and
Erfei Bi Adjacent positioning of cellular
structures enabled by a Cdc42
GTPase-activating protein-mediated zone
of inhibition . . . . . . . . . . . . . 1375
Berndt Müller and
Jane Blackburn and
Carmen Feijoo and
Xiujie Zhao and
Carl Smythe DNA-activated protein kinase functions
in a newly observed S phase checkpoint
that links histone mRNA abundance with
DNA replication . . . . . . . . . . . . 1385
Alexandre Blais and
Chris J. C. van Oevelen and
Raphaël Margueron and
Diego Acosta-Alvear and
Brian David Dynlacht Retinoblastoma tumor suppressor
protein-dependent methylation of histone
H3 lysine 27 is associated with
irreversible cell cycle exit . . . . . . 1399
Mathieu Tardat and
Rabih Murr and
Zdenko Herceg and
Claude Sardet and
Eric Julien PR-Set7-dependent lysine methylation
ensures genome replication and stability
through S phase . . . . . . . . . . . . 1413
Hugues Lelouard and
Enrico K. Schmidt and
Voahirana Camosseto and
Giovanna Clavarino and
Maurizio Ceppi and
Hsiang-Ting Hsu and
Philippe Pierre Regulation of translation is required
for dendritic cell function and survival
during activation . . . . . . . . . . . 1427
Yuichiro Kida and
Fumiko Morimoto and
Masao Sakaguchi Two translocating hydrophilic segments
of a nascent chain span the ER membrane
during multispanning protein topogenesis 1441
Stephen W. G. Tait and
Evert de Vries and
Chiel Maas and
Anna M. Keller and
Clive S. D'Santos and
Jannie Borst Apoptosis induction by Bid requires
unconventional ubiquitination and
degradation of its N-terminal fragment 1453
Paulo S. Ribeiro and
Erina Kuranaga and
Tencho Tenev and
François Leulier and
Masayuki Miura and
Pascal Meier DIAP2 functions as a mechanism-based
regulator of drICE that contributes to
the caspase activity threshold in living
cells . . . . . . . . . . . . . . . . . 1467
Tomoko Ohyama and
Patrik Verstreken and
Cindy V. Ly and
Tanja Rosenmund and
Akhila Rajan and
An-Chi Tien and
Claire Haueter and
Karen L. Schulze and
Hugo J. Bellen Huntingtin-interacting protein 14, a
palmitoyl transferase required for
exocytosis and targeting of CSP to
synaptic vesicles . . . . . . . . . . . 1481
Nadja Jung and
Martin Wienisch and
Mingyu Gu and
James B. Rand and
Sebastian L. Müller and
Gerd Krause and
Erik M. Jorgensen and
Jürgen Klingauf and
Volker Haucke Molecular basis of synaptic vesicle
cargo recognition by the endocytic
sorting adaptor stonin 2 . . . . . . . . 1497
Min Dong and
William H. Tepp and
Huisheng Liu and
Eric A. Johnson and
Edwin R. Chapman Mechanism of botulinum neurotoxin B and
G entry into hippocampal neurons . . . . 1511
Gareth R. Howell and
Richard T. Libby and
Tatjana C. Jakobs and
Richard S. Smith and
F. Campbell Phalan and
Joseph W. Barter and
Jessica M. Barbay and
Jeffrey K. Marchant and
Nagaraju Mahesh and
Vittorio Porciatti and
Alan V. Whitmore and
Richard H. Masland and
Simon W. M. John Axons of retinal ganglion cells are
insulted in the optic nerve early in
DBA/2J glaucoma . . . . . . . . . . . . 1523
Rosa Ana Lacalle and
Rosa M. Peregil and
Juan Pablo Albar and
Ernesto Merino and
Carlos Martínez-A and
Isabel Mérida and
Santos Mañes Type I phosphatidylinositol
$4$-phosphate $5$-kinase controls
neutrophil polarity and directional
movement . . . . . . . . . . . . . . . . 1539
Gray W. Pearson and
Tony Hunter Real-time imaging reveals that
noninvasive mammary epithelial acini can
contain motile cells . . . . . . . . . . 1555
Xinchun Pi and
Rongqin Ren and
Russell Kelley and
Chunlian Zhang and
Martin Moser and
Aparna B. Bohil and
Melinda DiVito and
Richard E. Cheney and
Cam Patterson Sequential roles for myosin--X in
BMP6-dependent filopodial extension,
migration, and activation of BMP
receptors . . . . . . . . . . . . . . . 1569
Klodiana Jani and
Frieder Schöck Zasp is required for the assembly of
functional integrin adhesion sites . . . 1583
Lisa M. Sevilla and
Rachida Nachat and
Karen R. Groot and
John F. Klement and
Jouni Uitto and
Philippe Djian and
Arto Määttä and
Fiona M. Watt Mice deficient in involucrin,
envoplakin, and periplakin have a
defective epidermal barrier . . . . . . 1599
Diana Stojanovski and
Bernard Guiard and
Vera Kozjak-Pavlovic and
Nikolaus Pfanner and
Chris Meisinger Alternative function for the
mitochondrial SAM complex in biogenesis
of $ \alpha $-helical TOM proteins . . . 1613
Mitch Leslie Backtracking on FAK . . . . . . . . . . ??
Mitch Leslie Traffic control in the ER . . . . . . . ??
Mitch Leslie Putting channels in their place . . . . ??
Mitch Leslie Genetic feng shui for cancer cells? . . ??
Mitch Leslie Tuning up mitochondria for angiogenesis ??
Caitlin Sedwick Gia Voeltz: Shaping ideas about ER shape 4
Marta Miaczynska and
Harald Stenmark Mechanisms and functions of endocytosis 7
Vann Bennett and
Jane Healy Being there: cellular targeting of
voltage-gated sodium channels in the
heart . . . . . . . . . . . . . . . . . 13
Wallace F. Marshall The cell biological basis of ciliary
disease . . . . . . . . . . . . . . . . 17
Jonathan M. Scholey Intraflagellar transport motors in
cilia: moving along the cell's antenna 23
Zhouhua Li and
Liwei Wang and
Thomas S. Hays and
Yu Cai Dynein-mediated apical localization of
crumbs transcripts is required for
Crumbs activity in epithelial polarity 31
Karen J. Meaburn and
Tom Misteli Locus-specific and activity-independent
gene repositioning during early
tumorigenesis . . . . . . . . . . . . . 39
R. Ileng Kumaran and
David L. Spector A genetic locus targeted to the nuclear
periphery in living cells maintains its
transcriptional competence . . . . . . . 51
Federica Madia and
Cristina Gattazzo and
Min Wei and
Paola Fabrizio and
William C. Burhans and
Martin Weinberger and
Abdoulaye Galbani and
Jesse R. Smith and
Christopher Nguyen and
Selina Huey and
Lucio Comai and
Valter D. Longo Longevity mutation in SCH9 prevents
recombination errors and premature
genomic instability in a Werner/Bloom
model system . . . . . . . . . . . . . . 67
Ivana Novak and
Hong Wang and
Ekaterina Revenkova and
Rolf Jessberger and
Harry Scherthan and
Christer Höög Cohesin Smc1$ \beta $ determines meiotic
chromatin axis loop organization . . . . 83
Melissa K. Gardner and
Julian Haase and
Karthikeyan Mythreye and
Jeffrey N. Molk and
MaryBeth Anderson and
Ajit P. Joglekar and
Eileen T. O'Toole and
Mark Winey and
E. D. Salmon and
David J. Odde and
Kerry Bloom The microtubule-based motor Kar3 and
plus end--binding protein Bim1 provide
structural support for the anaphase
spindle . . . . . . . . . . . . . . . . 91
Michael Schleicher and
Benjamin R. Shepherd and
Yajaira Suarez and
Carlos Fernandez-Hernando and
Jun Yu and
Yong Pan and
Lisette M. Acevedo and
Gerald S. Shadel and
William C. Sessa Prohibitin-1 maintains the angiogenic
capacity of endothelial cells by
regulating mitochondrial function and
senescence . . . . . . . . . . . . . . . 101
Rachid Mazroui and
Sergio Di Marco and
Eveline Clair and
Christopher von Roretz and
Scott A. Tenenbaum and
Jack D. Keene and
Maya Saleh and
Imed-Eddine Gallouzi Caspase-mediated cleavage of HuR in the
cytoplasm contributes to pp32/PHAP--I
regulation of apoptosis . . . . . . . . 113
Hisao Nagaya and
Taku Tamura and
Arisa Higa-Nishiyama and
Koji Ohashi and
Mayumi Takeuchi and
Hitoshi Hashimoto and
Kiyotaka Hatsuzawa and
Masataka Kinjo and
Tatsuya Okada and
Ikuo Wada Regulated motion of glycoproteins
revealed by direct visualization of a
single cargo in the endoplasmic
reticulum . . . . . . . . . . . . . . . 129
Xiaoyu Zhang and
Kelly Orlando and
Bing He and
Fengong Xi and
Jian Zhang and
Allison Zajac and
Wei Guo Membrane association and functional
regulation of Sec3 by phospholipids and
Cdc42 . . . . . . . . . . . . . . . . . 145
Ian G. Ganley and
Eric Espinosa and
Suzanne R. Pfeffer A syntaxin 10-SNARE complex
distinguishes two distinct transport
routes from endosomes to the trans-Golgi
in human cells . . . . . . . . . . . . . 159
John S. Lowe and
Oleg Palygin and
Naina Bhasin and
Thomas J. Hund and
Penelope A. Boyden and
Erwin Shibata and
Mark E. Anderson and
Peter J. Mohler Voltage-gated Na$_v$ channel targeting
in the heart requires an
ankyrin--G-dependent cellular pathway 173
Yangmi Lim and
Ssang-Taek Lim and
Alok Tomar and
Margaret Gardel and
Joie A. Bernard-Trifilo and
Xiao Lei Chen and
Sean A. Uryu and
Rafaela Canete-Soler and
Jinbin Zhai and
Hong Lin and
William W. Schlaepfer and
Perihan Nalbant and
Gary Bokoch and
Dusko Ilic and
Clare Waterman-Storer and
David D. Schlaepfer PyK2 and FAK connections to p190Rho
guanine nucleotide exchange factor
regulate RhoA activity, focal adhesion
formation, and cell motility . . . . . . 187
Peter M. Benz and
Constanze Blume and
Jan Moebius and
Chris Oschatz and
Kai Schuh and
Albert Sickmann and
Ulrich Walter and
Stephan M. Feller and
Thomas Renné Cytoskeleton assembly at endothelial
cell--cell contacts is regulated by $
\alpha $II--spectrin--VASP complexes . . 205
Chunyue Yin and
Maria Kiskowski and
Philippe-Alexandre Pouille and
Emmanuel Farge and
Lilianna Solnica-Krezel Cooperation of polarized cell
intercalations drives convergence and
extension of presomitic mesoderm during
zebrafish gastrulation . . . . . . . . . 221
Xuelin Wang and
Wei Zhang and
Thomas Cheever and
Valentin Schwarz and
Karla Opperman and
Harald Hutter and
Deanna Koepp and
Lihsia Chen The \bionameC. elegans L1CAM homologue
LAD-2 functions as a coreceptor in
MAB-20/Sema2-mediated axon guidance . . 233
Nicole LeBrasseur Septins clear high speed tracks . . . . ??
Nicole LeBrasseur ESCRT rings around the membrane . . . . ??
Nicole LeBrasseur ICAP for sensing matrix density . . . . ??
Nicole LeBrasseur Spokes coordinate flagella . . . . . . . ??
Richard Robinson Histone chaperone regulates replication ??
Richard Robinson Simple forces, complex shapes . . . . . ??
Richard Robinson Learn more when your neighbors do . . . ??
Richard Robinson Organelles in parallel . . . . . . . . . ??
Richard Robinson H$^+$, the tiniest transmitter . . . . . ??
Nicole LeBrasseur Alan Aderem: From molecules to megabytes 252
Mike Rossner and
Heather Van Epps and
Emma Hill Irreproducible results: a response to
Thomson Scientific . . . . . . . . . . . 254
Haifan Lin Cell biology of stem cells: an enigma of
asymmetry and self-renewal . . . . . . . 257
Yukiko M. Yamashita and
Margaret T. Fuller Asymmetric centrosome behavior and the
mechanisms of stem cell division . . . . 261
William Chia and
W. Gregory Somers and
Hongyan Wang Drosophila neuroblast asymmetric
divisions: cell cycle regulators,
asymmetric protein localization, and
tumorigenesis . . . . . . . . . . . . . 267
Elaine Fuchs Skin stem cells: rising to the surface 273
Gilles R. X. Hickson and
Patrick H. O'Farrell Rho-dependent control of anillin
behavior during cytokinesis . . . . . . 285
Elias T. Spiliotis and
Stephen J. Hunt and
Qicong Hu and
Makoto Kinoshita and
W. James Nelson Epithelial polarity requires septin
coupling of vesicle transport to
polyglutamylated microtubules . . . . . 295
Livia Maria Pirzio and
Pietro Pichierri and
Margherita Bignami and
Annapaola Franchitto Werner syndrome helicase activity is
essential in maintaining fragile site
stability . . . . . . . . . . . . . . . 305
Kieran Ritchie and
Claudia Seah and
Jana Moulin and
Christian Isaac and
Frederick Dick and
Nathalie G. Bérubé Loss of ATRX leads to chromosome
cohesion and congression defects . . . . 315
Fangfang Liu and
Seng Kah Ng and
Yanfen Lu and
Wilson Low and
Julian Lai and
Gregory Jedd Making two organelles from one: Woronin
body biogenesis by peroxisomal protein
sorting . . . . . . . . . . . . . . . . 325
Erinna F. Lee and
Peter E. Czabotar and
Mark F. van Delft and
Ewa M. Michalak and
Michelle J. Boyle and
Simon N. Willis and
Hamsa Puthalakath and
Philippe Bouillet and
Peter M. Colman and
David C. S. Huang and
W. Douglas Fairlie A novel BH3 ligand that selectively
targets Mcl-1 reveals that apoptosis can
proceed without Mcl-1 degradation . . . 341
Paolo M. Mangahas and
Xiaomeng Yu and
Kenneth G. Miller and
Zheng Zhou The small GTPase Rab2 functions in the
removal of apoptotic cells in
\bionameCaenorhabditis elegans . . . . . 357
Dumaine Williams and
Jeffrey E. Pessin Mapping of R--SNARE function at distinct
intracellular GLUT4 trafficking steps in
adipocytes . . . . . . . . . . . . . . . 375
Phyllis I. Hanson and
Robyn Roth and
Yuan Lin and
John E. Heuser Plasma membrane deformation by circular
arrays of ESCRT--III protein filaments 389
Chun Yang and
Heather A. Owen and
Pinfen Yang Dimeric heat shock protein 40 binds
radial spokes for generating coupled
power strokes and recovery strokes of 9
+ 2 flagella . . . . . . . . . . . . . . 403
Janine Prange-Kiel and
Hubertus Jarry and
Michael Schoen and
Patrick Kohlmann and
Christina Lohse and
Lepu Zhou and
Gabriele M. Rune Gonadotropin-releasing hormone regulates
spine density via its regulatory role in
hippocampal estrogen synthesis . . . . . 417
Angélique Millon-Frémillon and
Daniel Bouvard and
Alexei Grichine and
Sandra Manet-Dupé and
Marc R. Block and
Corinne Albiges-Rizo Cell adaptive response to extracellular
matrix density is controlled by
ICAP-1-dependent $ \beta_1 $-integrin
affinity . . . . . . . . . . . . . . . . 427
Mitch Leslie Stuck on the membrane . . . . . . . . . ??
Mitch Leslie Proteins gang up on HIV . . . . . . . . ??
Mitch Leslie Supersized lipid droplets . . . . . . . ??
Mitch Leslie When cilia lose the beat . . . . . . . . ??
Mitch Leslie Helping an axon go long . . . . . . . . ??
Nicole LeBrasseur DNA spring in your spindle . . . . . . . ??
Nicole LeBrasseur Nanotubes spread HIV . . . . . . . . . . ??
Nicole LeBrasseur Cleaning the kidney's filter . . . . . . ??
Nicole LeBrasseur Transcription factor translated in axons ??
Ruth Williams Jernej Ule: an RNA runaway success . . . 448
Geertrui Denecker and
Petra Ovaere and
Peter Vandenabeele and
Wim Declercq Caspase-14 reveals its secrets . . . . . 451
Jianwei Zou and
Mark A. Hallen and
Christine D. Yankel and
Sharyn A. Endow A microtubule-destabilizing kinesin
motor regulates spindle length and
anchoring in oocytes . . . . . . . . . . 459
Intaek Lee and
Balraj Doray and
Jennifer Govero and
Stuart Kornfeld Binding of cargo sorting signals to AP-1
enhances its association with ADP
ribosylation factor 1--GTP . . . . . . . 467
Weihua Fei and
Guanghou Shui and
Bruno Gaeta and
Ximing Du and
Lars Kuerschner and
Peng Li and
Andrew J. Brown and
Markus R. Wenk and
Robert G. Parton and
Hongyuan Yang Fld1p, a functional homologue of human
seipin, regulates the size of lipid
droplets in yeast . . . . . . . . . . . 473
Marc Hammarlund and
Shigeki Watanabe and
Kim Schuske and
Erik M. Jorgensen CAPS and syntaxin dock dense core
vesicles to the plasma membrane in
neurons . . . . . . . . . . . . . . . . 483
Kiyoshi Tahara and
Masatoshi Takagi and
Miho Ohsugi and
Takefumi Sone and
Fumiko Nishiumi and
Kazuhiro Maeshima and
Yasuomi Horiuchi and
Noriko Tokai-Nishizumi and
Fumio Imamoto and
Tadashi Yamamoto and
Shingo Kose and
Naoko Imamoto Importin-$ \beta $ and the small
guanosine triphosphatase Ran mediate
chromosome loading of the human
chromokinesin Kid . . . . . . . . . . . 493
Jakub K. Famulski and
Larissa Vos and
Xuejun Sun and
Gordon Chan Stable hZW10 kinetochore residency,
mediated by hZwint-1 interaction, is
essential for the mitotic checkpoint . . 507
Shan Gao and
Maria Grazia Giansanti and
Graham J. Buttrick and
Sharada Ramasubramanyan and
Adam Auton and
Maurizio Gatti and
James G. Wakefield Australin: a chromosomal passenger
protein required specifically for
\bionameDrosophila melanogaster male
meiosis . . . . . . . . . . . . . . . . 521
Graham J. Buttrick and
Luke M. A. Beaumont and
Jessica Leitch and
Christopher Yau and
Julian R. Hughes and
James G. Wakefield Akt regulates centrosome migration and
spindle orientation in the early
\bionameDrosophila melanogaster embryo 537
Edward M. Campbell and
Omar Perez and
Jenny L. Anderson and
Thomas J. Hope Visualization of a
proteasome-independent intermediate
during restriction of HIV-1 by rhesus
TRIM5$ \alpha $ . . . . . . . . . . . . 549
Rongmin Zhao and
Yoshito Kakihara and
Anna Gribun and
Jennifer Huen and
Guocheng Yang and
May Khanna and
Michael Costanzo and
Renée L. Brost and
Charles Boone and
Timothy R. Hughes and
Christopher M. Yip and
Walid A. Houry Molecular chaperone Hsp90 stabilizes
Pih1/Nop17 to maintain R2TP complex
activity that regulates snoRNA
accumulation . . . . . . . . . . . . . . 563
Séverine Boulon and
Nathalie Marmier-Gourrier and
Béreng\`ere Pradet-Balade and
Laurence Wurth and
Céline Verheggen and
Beáta E. Jády and
Benjamin Rothé and
Christina Pescia and
Marie-Cécile Robert and
Tamás Kiss and
Barbara Bardoni and
Alain Krol and
Christiane Branlant and
Christine Allmang and
Edouard Bertrand and
Bruno Charpentier The Hsp90 chaperone controls the
biogenesis of L7Ae RNPs through
conserved machinery . . . . . . . . . . 579
Daniela D'Andrea and
Giovanna L. Liguori and
J. Ann Le Good and
Enza Lonardo and
Olov Andersson and
Daniel B. Constam and
Maria G. Persico and
Gabriella Minchiotti Cripto promotes A--P axis specification
independently of its stimulatory effect
on Nodal autoinduction . . . . . . . . . 597
Raz Ben-Yair and
Chaya Kalcheim Notch and bone morphogenetic protein
differentially act on dermomyotome cells
to generate endothelium, smooth, and
striated muscle . . . . . . . . . . . . 607
Harald Witte and
Dorothee Neukirchen and
Frank Bradke Microtubule stabilization specifies
initial neuronal polarization . . . . . 619
Karl-Ferdinand Lechtreck and
Philippe Delmotte and
Michael L. Robinson and
Michael J. Sanderson and
George B. Witman Mutations in Hydin impair ciliary
motility in mice . . . . . . . . . . . . 633
Irina Raykhel and
Heli Alanen and
Kirsi Salo and
Jaana Jurvansuu and
Van Dat Nguyen and
Maria Latva-Ranta and
Lloyd Ruddock A molecular specificity code for the
three mammalian KDEL receptors . . . . . 645
Nicole LeBrasseur Trafficking from cell surface to nuclear
envelope . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Quick hops on and off plus ends . . . . ??
Nicole LeBrasseur An adhesion kinase on centrosomes . . . ??
Nicole LeBrasseur Losing odd chromosomes . . . . . . . . . ??
Nicole LeBrasseur Matching traffic and growth . . . . . . ??
Richard Robinson Embryos need Mom's nucleolus . . . . . . ??
Richard Robinson T cells count and then decide . . . . . ??
Richard Robinson Reach out and gRab something . . . . . . ??
Richard Robinson Self-assembly of the cell wall . . . . . ??
Richard Robinson Kinesin's parts pull together . . . . . ??
Ruth Williams Brian Chait: Master of mass spectrometry 652
Nicole LeBrasseur and
Ruth Williams Capital Cells: The American Society for
Cell Biology, Washington, D.C., December
1--5, 2007 . . . . . . . . . . . . . . . 654
Karen W. Yuen and
Arshad Desai The wages of CIN . . . . . . . . . . . . 661
Sarah L. Thompson and
Duane A. Compton Examining the link between chromosomal
instability and aneuploidy in human
cells . . . . . . . . . . . . . . . . . 665
Fang Yang and
Sigrid Eckardt and
N. Adrian Leu and
K. John McLaughlin and
Peijing Jeremy Wang Mouse TEX15 is essential for DNA
double-strand break repair and
chromosomal synapsis during male meiosis 673
Andrew B. Fielding and
Iveta Dobreva and
Paul C. McDonald and
Leonard J. Foster and
Shoukat Dedhar Integrin-linked kinase localizes to the
centrosome and regulates mitotic spindle
organization . . . . . . . . . . . . . . 681
Kieran F. Harvey and
Jaakko Mattila and
Avi Sofer and
F. Christian Bennett and
Matthew R. Ramsey and
Leif W. Ellisen and
Oscar Puig and
Iswar K. Hariharan FOXO-regulated transcription restricts
overgrowth of Tsc mutant organs . . . . 691
Min Chen and
Lena Singer and
Andrea Scharf and
Anna von Mikecz Nuclear polyglutamine-containing protein
aggregates as active proteolytic centers 697
Beat Nyfeler and
Veronika Reiterer and
Markus W. Wendeler and
Eduard Stefan and
Bin Zhang and
Stephen W. Michnick and
Hans-Peter Hauri Identification of ERGIC-53 as an
intracellular transport receptor of $
\alpha_1 $-antitrypsin . . . . . . . . . 705
Auxiliadora Aguilera-Romero and
Joanna Kaminska and
Anne Spang and
Howard Riezman and
Manuel Muñiz The yeast p24 complex is required for
the formation of COPI retrograde
transport vesicles from the Golgi
apparatus . . . . . . . . . . . . . . . 713
Liwei Wang and
Zhouhua Li and
Yu Cai The JAK/STAT pathway positively
regulates DPP signaling in the
\bionameDrosophila germline stem cell
niche . . . . . . . . . . . . . . . . . 721
Katharina A. Dragestein and
Wiggert A. van Cappellen and
Jeffrey van Haren and
George D. Tsibidis and
Anna Akhmanova and
Tobias A. Knoch and
Frank Grosveld and
Niels Galjart Dynamic behavior of GFP--CLIP--170
reveals fast protein turnover on
microtubule plus ends . . . . . . . . . 729
Sébastien Carreno and
Ilektra Kouranti and
Edith Szafer Glusman and
Margaret T. Fuller and
Arnaud Echard and
François Payre Moesin and its activating kinase Slik
are required for cortical stability and
microtubule organization in mitotic
cells . . . . . . . . . . . . . . . . . 739
Douwe M. Veltman and
Ineke Keizer-Gunnik and
Peter J. M. Van Haastert Four key signaling pathways mediating
chemotaxis in \bionameDictyostelium
discoideum . . . . . . . . . . . . . . . 747
Thomas Vaccari and
Han Lu and
Ritu Kanwar and
Mark E. Fortini and
David Bilder Endosomal entry regulates Notch receptor
activation in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 755
Miki Hieda and
Mayumi Isokane and
Michiko Koizumi and
Chiduru Higashi and
Taro Tachibana and
Masachika Shudou and
Tomohiko Taguchi and
Yohki Hieda and
Shigeki Higashiyama Membrane-anchored growth factor,
HB--EGF, on the cell surface targeted to
the inner nuclear membrane . . . . . . . 763
Alexander Dammermann and
Paul S. Maddox and
Arshad Desai and
Karen Oegema SAS-4 is recruited to a dynamic
structure in newly forming centrioles
that is stabilized by the $ \gamma
$-tubulin-mediated addition of
centriolar microtubules . . . . . . . . 771
Nadine Bakkar and
Jingxin Wang and
Katherine J. Ladner and
Huating Wang and
Jason M. Dahlman and
Micheal Carathers and
Swarnali Acharyya and
Michael A. Rudnicki and
Andrew D. Hollenbach and
Denis C. Guttridge IKK\slash NF-$ \kappa $B regulates
skeletal myogenesis via a signaling
switch to inhibit differentiation and
promote mitochondrial biogenesis . . . . 787
Anastasia Blagoveshchenskaya and
Fei Ying Cheong and
Holger M. Rohde and
Greta Glover and
Andreas Knödler and
Teresa Nicolson and
Guido Boehmelt and
Peter Mayinger Integration of Golgi trafficking and
growth factor signaling by the lipid
phosphatase SAC1 . . . . . . . . . . . . 803
Hui Jin and
J. Michael McCaffery and
Eric Grote Ergosterol promotes pheromone signaling
and plasma membrane fusion in mating
yeast . . . . . . . . . . . . . . . . . 813
Chan Choo Yap and
Dolora Wisco and
Pekka Kujala and
Zofia M. Lasiecka and
Johanna T. Cannon and
Michael C. Chang and
Harald Hirling and
Judith Klumperman and
Bettina Winckler The somatodendritic endosomal regulator
NEEP21 facilitates axonal targeting of
L1/NgCAM . . . . . . . . . . . . . . . . 827
Berndt Müller and
Jane Blackburn and
Carmen Feijoo and
Xiujie Zhao and
Carl Smythe DNA-activated protein kinase functions
in a newly observed S phase checkpoint
that links histone mRNA abundance with
DNA replication . . . . . . . . . . . . 843
Mitch Leslie How to escape from a macrophage . . . . ??
Mitch Leslie Making the wrong connections in epilepsy ??
Mitch Leslie Origins of mitotic inequality . . . . . ??
Mitch Leslie Cells' puncture repair kit . . . . . . . ??
Mitch Leslie SIRT2 stops cells . . . . . . . . . . . ??
Nicole LeBrasseur Plasma membrane in Golgi costume . . . . ??
Nicole LeBrasseur Rb turns up mitochondria . . . . . . . . ??
Nicole LeBrasseur Sopping up chemokine . . . . . . . . . . ??
Nicole LeBrasseur Variety in leading edge actin . . . . . ??
Ruth Williams Jennifer Zallen: Decoding the
developmental dance . . . . . . . . . . 850
Liang Cai and
James E. Bear Peering deeply inside the branch . . . . 853
Elisa Dultz and
Esther Zanin and
Claudia Wurzenberger and
Marion Braun and
Gwénaël Rabut and
Lucia Sironi and
Jan Ellenberg Systematic kinetic analysis of mitotic
dis- and reassembly of the nuclear pore
in living cells . . . . . . . . . . . . 857
Hideki Yokoyama and
Oliver J. Gruss and
Sofia Rybina and
Ma\"\iwen Caudron and
Malgorzata Schelder and
Matthias Wilm and
Iain W. Mattaj and
Eric Karsenti Cdk11 is a RanGTP-dependent microtubule
stabilization factor that regulates
spindle assembly rate . . . . . . . . . 867
David M. Rivers and
Sergio Moreno and
Mary Abraham and
Julie Ahringer PAR proteins direct asymmetry of the
cell cycle regulators Polo-like kinase
and Cdc25 . . . . . . . . . . . . . . . 877
Isabelle Rouiller and
Xiao-Ping Xu and
Kurt J. Amann and
Coumaran Egile and
Stephan Nickell and
Daniela Nicastro and
Rong Li and
Thomas D. Pollard and
Niels Volkmann and
Dorit Hanein The structural basis of actin filament
branching by the Arp2/3 complex . . . . 887
Enko N. Kiprilov and
Aashir Awan and
Romain Desprat and
Michelle Velho and
Christian A. Clement and
Anne Grete Byskov and
Claus Y. Andersen and
Peter Satir and
Eric E. Bouhassira and
Sòren T. Christensen and
Rhoda Elison Hirsch Human embryonic stem cells in culture
possess primary cilia with hedgehog
signaling machinery . . . . . . . . . . 897
Vincent Idone and
Christina Tam and
John W. Goss and
Derek Toomre and
Marc Pypaert and
Norma W. Andrews Repair of injured plasma membrane by
rapid Ca$^{2+}$-dependent endocytosis 905
Ruwin Pandithage and
Richard Lilischkis and
Kai Harting and
Alexandra Wolf and
Britta Jedamzik and
Juliane Lüscher-Firzlaff and
Jörg Vervoorts and
Edwin Lasonder and
Elisabeth Kremmer and
Bernd Knöll and
Bernhard Lüscher The regulation of SIRT2 function by
cyclin-dependent kinases affects cell
motility . . . . . . . . . . . . . . . . 915
Gayatri Pal and
Maria T. Z. Paraz and
Douglas R. Kellogg Regulation of Mih1/Cdc25 by protein
phosphatase 2A and casein kinase 1 . . . 931
Gergana Galabova-Kovacs and
Federica Catalanotti and
Dana Matzen and
Gloria X. Reyes and
Jürgen Zezula and
Ruth Herbst and
Alcino Silva and
Ingrid Walter and
Manuela Baccarini Essential role of B--Raf in
oligodendrocyte maturation and
myelination during postnatal central
nervous system development . . . . . . . 947
Christa L. Cortesio and
Keefe T. Chan and
Benjamin J. Perrin and
Nicholas O. Burton and
Sheng Zhang and
Zhong-Yin Zhang and
Anna Huttenlocher Calpain 2 and PTP1B function in a novel
pathway with Src to regulate invadopodia
dynamics and breast cancer cell invasion 957
Andrew R. Jauregui and
Ken C. Q. Nguyen and
David H. Hall and
Maureen M. Barr The \bionameCaenorhabditis elegans
nephrocystins act as global modifiers of
cilium structure . . . . . . . . . . . . 973
Richard K. Tsai and
Dennis E. Discher Inhibition of ``self'' engulfment
through deactivation of myosin--II at
the phagocytic synapse between human
cells . . . . . . . . . . . . . . . . . 989
Kostandin V. Pajcini and
Jason H. Pomerantz and
Ozan Alkan and
Regis Doyonnas and
Helen M. Blau Myoblasts and macrophages share
molecular components that contribute to
cell--cell fusion . . . . . . . . . . . 1005
Grzegorz M. Wilczynski and
Filip A. Konopacki and
Ewa Wilczek and
Zofia Lasiecka and
Adam Gorlewicz and
Piotr Michaluk and
Marcin Wawrzyniak and
Monika Malinowska and
Pawel Okulski and
Lukasz R. Kolodziej and
Witold Konopka and
Kamila Duniec and
Barbara Mioduszewska and
Evgeni Nikolaev and
Agnieszka Walczak and
Dorota Owczarek and
Dariusz C. Gorecki and
Werner Zuschratter and
Ole Petter Ottersen and
Leszek Kaczmarek Important role of matrix
metalloproteinase 9 in epileptogenesis 1021
Hao-Ven Wang and
Ling-Wei Chang and
Klara Brixius and
Sara A. Wickström and
Eloi Montanez and
Ingo Thievessen and
Martin Schwander and
Ulrich Müller and
Wilhelm Bloch and
Ulrike Mayer and
Reinhard Fässler Integrin-linked kinase stabilizes
myotendinous junctions and protects
muscle from stress-induced damage . . . 1037
Nicole LeBrasseur Lamellipodia fight back formin . . . . . ??
Nicole LeBrasseur Myosin chaperones: from A to Z and back ??
Nicole LeBrasseur The SR finds the translocon . . . . . . ??
Nicole LeBrasseur Early origins sound S phase alarm . . . ??
Richard Robinson GABA fine-tunes the glycine receptor . . ??
Richard Robinson To fold, first unfold . . . . . . . . . ??
Richard Robinson New exit: caspase-1 for secretion . . . ??
Richard Robinson How the ER gets its shape . . . . . . . ??
Richard Robinson Lipid is new Star in nuclear regulation ??
Ruth Williams Elizabeth Blackburn: Because science is
worth it . . . . . . . . . . . . . . . . 1056
Marko Kaksonen Taking apart the endocytic machinery . . 1059
Thoru Pederson As functional nuclear actin comes into
view, is it globular, filamentous, or
both? . . . . . . . . . . . . . . . . . 1061
Ioannis P. Nezis and
Anne Simonsen and
Antonia P. Sagona and
Kim Finley and
Sébastien Gaumer and
Didier Contamine and
Tor Erik Rusten and
Harald Stenmark and
Andreas Brech Ref(2)P, the \bionameDrosophila
melanogaster homologue of mammalian p62,
is required for the formation of protein
aggregates in adult brain . . . . . . . 1065
Julie M. Caldwell and
Yinhuai Chen and
Kaila L. Schollaert and
James F. Theis and
George F. Babcock and
Carol S. Newlon and
Yolanda Sanchez Orchestration of the S-phase and DNA
damage checkpoint pathways by
replication forks from early origins . . 1073
Xiao-qing Gan and
Ji-yong Wang and
Ying Xi and
Zhi-li Wu and
Yi-ping Li and
Lin Li Nuclear Dvl, c--Jun, $ \beta $-catenin,
and TCF form a complex leading to
stabiLization of $ \beta $--catenin--TCF
interaction . . . . . . . . . . . . . . 1087
Peter Hemmerich and
Stefanie Weidtkamp-Peters and
Christian Hoischen and
Lars Schmiedeberg and
Indri Erliandri and
Stephan Diekmann Dynamics of inner kinetochore assembly
and maintenance in living cells . . . . 1101
Norihiko Nakazawa and
Takahiro Nakamura and
Aya Kokubu and
Masahiro Ebe and
Koji Nagao and
Mitsuhiro Yanagida Dissection of the essential steps for
condensin accumulation at kinetochores
and rDNAs during fission yeast mitosis 1115
Kazuhito Toyo-oka and
Daisuke Mori and
Yoshihisa Yano and
Masayuki Shiota and
Hiroshi Iwao and
Hidemasa Goto and
Masaki Inagaki and
Noriko Hiraiwa and
Masami Muramatsu and
Anthony Wynshaw-Boris and
Atsushi Yoshiki and
Shinji Hirotsune Protein phosphatase 4 catalytic subunit
regulates Cdk1 activity and microtubule
organization via NDEL1 dephosphorylation 1133
Ying Jiang and
Zhiliang Cheng and
Elisabet C. Mandon and
Reid Gilmore An interaction between the SRP receptor
and the translocon is critical during
cotranslational protein translocation 1149
Christelle Etard and
Urmas Roostalu and
Uwe Strähle Shuttling of the chaperones Unc45b and
Hsp90a between the A band and the Z line
of the myofibril . . . . . . . . . . . . 1163
Jianjun Wang and
Chuan-En Wang and
Adam Orr and
Suzanne Tydlacka and
Shi-Hua Li and
Xiao-Jiang Li Impaired ubiquitin--proteasome system
activity in the synapses of Huntington's
disease mice . . . . . . . . . . . . . . 1177
Ruth I. Johnson and
Midori J. Seppa and
Ross L. Cagan The \bionameDrosophila CD2AP/CIN85
orthologue Cindr regulates junctions and
cytoskeleton dynamics during tissue
patterning . . . . . . . . . . . . . . . 1191
Ingrid Roxrud and
Camilla Raiborg and
Nina Marie Pedersen and
Espen Stang and
Harald Stenmark An endosomally localized isoform of
Eps15 interacts with Hrs to mediate
degradation of epidermal growth factor
receptor . . . . . . . . . . . . . . . . 1205
Fatima-Zahra Idrissi and
Helga Grötsch and
Isabel M. Fernández-Golbano and
Cristina Presciatto-Baschong and
Howard Riezman and
María-Isabel Geli Distinct acto/myosin--I structures
associate with endocytic profiles at the
plasma membrane . . . . . . . . . . . . 1219
Maria Nemethova and
Sonja Auinger and
J. Victor Small Building the actin cytoskeleton:
filopodia contribute to the construction
of contractile bundles in the lamella 1233
Corina Sarmiento and
Weigang Wang and
Athanassios Dovas and
Hideki Yamaguchi and
Mazen Sidani and
Mirvat El-Sibai and
Vera DesMarais and
Holly A. Holman and
Susan Kitchen and
Jonathan M. Backer and
Art Alberts and
John Condeelis WASP family members and formin proteins
coordinate regulation of cell
protrusions in carcinoma cells . . . . . 1245
Jacky G. Goetz and
Bharat Joshi and
Patrick Lajoie and
Scott S. Strugnell and
Trevor Scudamore and
Liliana D. Kojic and
Ivan R. Nabi Concerted regulation of focal adhesion
dynamics by galectin-3 and
tyrosine-phosphorylated caveolin-1 . . . 1261
Yasushi Shintani and
Yuri Fukumoto and
Nina Chaika and
Robert Svoboda and
Margaret J. Wheelock and
Keith R. Johnson Collagen I-mediated up-regulation of
N-cadherin requires cooperative signals
from integrins and discoidin domain
receptor 1 . . . . . . . . . . . . . . . 1277
Mitch Leslie Stem cell slowdown . . . . . . . . . . . ??
Mitch Leslie Career change for a mitotic protein . . ??
Mitch Leslie Neurons on life support . . . . . . . . ??
Mitch Leslie Hauling tail . . . . . . . . . . . . . . ??
Mitch Leslie Short proteins got no reason to leave ??
Nicole LeBrasseur Spine actin for memory . . . . . . . . . ??
Nicole LeBrasseur Motor tug-of-war is productive . . . . . ??
Nicole LeBrasseur Stem cells sport longest telomeres . . . ??
Nicole LeBrasseur Enzyme shapes mitochondria . . . . . . . ??
Nicole LeBrasseur Myosin and kinesin collaborate . . . . . ??
Ruth Williams Richard Gardner: Nuclear garbologist . . 6
Eran Meshorer and
Yosef Gruenbaum Gone with the Wnt/Notch: stem cells in
laminopathies, progeria, and aging . . . 9
Rajeshwari R. Valiathan and
Lois S. Weisman Pushing for answers: is myosin V
directly involved in moving
mitochondria? . . . . . . . . . . . . . 15
Léa Trichet and
Cécile Sykes and
Julie Plastino Relaxing the actin cytoskeleton for
adhesion and movement with Ena/VASP . . 19
Jesús Espada and
Ignacio Varela and
Ignacio Flores and
Alejandro P. Ugalde and
Juan Cadiñanos and
Alberto M. Pendás and
Colin L. Stewart and
Karl Tryggvason and
María A. Blasco and
José M. P. Freije and
Carlos López-Otín Nuclear envelope defects cause stem cell
dysfunction in premature-aging mice . . 27
Philip Van Damme and
Annelies Van Hoecke and
Diether Lambrechts and
Peter Vanacker and
Elke Bogaert and
John van Swieten and
Peter Carmeliet and
Ludo Van Den Bosch and
Wim Robberecht Progranulin functions as a neurotrophic
factor to regulate neurite outgrowth and
enhance neuronal survival . . . . . . . 37
Sara M. Weis and
Ssang-Taek Lim and
Kimberly M. Lutu-Fuga and
Leo A. Barnes and
Xiao Lei Chen and
Joachim R. Göthert and
Tang-Long Shen and
Jun-Lin Guan and
David D. Schlaepfer and
David A. Cheresh Compensatory role for Pyk2 during
angiogenesis in adult mice lacking
endothelial cell FAK . . . . . . . . . . 43
Biljana Culjkovic and
Keith Tan and
Slobodanka Orolicki and
Abdellatif Amri and
Sylvain Meloche and
Katherine L. B. Borden The eIF4E RNA regulon promotes the Akt
signaling pathway . . . . . . . . . . . 51
Akiko Seki and
Judith A. Coppinger and
Haining Du and
Chang-Young Jang and
John R. Yates and
Guowei Fang Plk1- and $ \beta $-TrCP-dependent
degradation of Bora controls mitotic
progression . . . . . . . . . . . . . . 65
Dawn M. Clifford and
Benjamin A. Wolfe and
Rachel H. Roberts-Galbraith and
W. Hayes McDonald and
John R. Yates and
Kathleen L. Gould The Clp1/Cdc14 phosphatase contributes
to the robustness of cytokinesis by
association with anillin-related Mid1 79
Hiroyuki Nakajima and
Shigenobu Yonemura and
Masayuki Murata and
Nobuhiro Nakamura and
Helen Piwnica-Worms and
Eisuke Nishida Myt1 protein kinase is essential for
Golgi and ER assembly during mitotic
exit . . . . . . . . . . . . . . . . . . 89
Paolo Ronchi and
Sara Colombo and
Maura Francolini and
Nica Borgese Transmembrane domain-dependent
partitioning of membrane proteins within
the endoplasmic reticulum . . . . . . . 105
Katrin Altmann and
Martina Frank and
Daniel Neumann and
Stefan Jakobs and
Benedikt Westermann The class V myosin motor protein, Myo2,
plays a major role in mitochondrial
motility in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 119
Kyoko Kawasaki and
Tetsuro Watabe and
Hitoshi Sase and
Masanori Hirashima and
Hiroshi Koide and
Yasuyuki Morishita and
Keiko Yuki and
Toshikuni Sasaoka and
Toshio Suda and
Motoya Katsuki and
Kohei Miyazono and
Keiji Miyazawa Ras signaling directs endothelial
specification of VEGFR2$^+$ vascular
progenitor cells . . . . . . . . . . . . 131
Jacqueline Fernandes and
Ivan M. Lorenzo and
Yaniré N. Andrade and
Anna Garcia-Elias and
Selma A. Serra and
José M. Fernández-Fernández and
Miguel A. Valverde IP$_3$ sensitizes TRPV4 channel to the
mechano- and osmotransducing messenger
5'-6'-epoxyeicosatrienoic acid . . . . . 143
Cindy V. Ly and
Chi-Kuang Yao and
Patrik Verstreken and
Tomoko Ohyama and
Hugo J. Bellen straightjacket is required for the
synaptic stabilization of cacophony, a
voltage-gated calcium channel $ \alpha_1
$ subunit . . . . . . . . . . . . . . . 157
Junjie Lu and
David M. Gilbert Proliferation-dependent and cell
cycle--regulated transcription of mouse
pericentric heterochromatin . . . . . . 171
Nicole LeBrasseur Polarizing for furrows . . . . . . . . . ??
Nicole LeBrasseur Lamins position PCNA . . . . . . . . . . ??
Nicole LeBrasseur Phosphorylation for break repair . . . . ??
Nicole LeBrasseur An eIF for proliferation . . . . . . . . ??
Richard Robinson Embryos experience tension . . . . . . . ??
Richard Robinson Transcribing ``silent'' DNA resilences
it . . . . . . . . . . . . . . . . . . . ??
Richard Robinson Pack loose, grow long . . . . . . . . . ??
Richard Robinson MukBs cooperate to loop DNA . . . . . . ??
Richard Robinson Motors bring genes together . . . . . . ??
Ruth Williams Sir John Gurdon: Godfather of cloning 178
Brian Seed and
Ramnik Xavier Spinophilin and the immune synapse . . . 181
Michael P. Rout The peroxisome: a production in four
acts . . . . . . . . . . . . . . . . . . 185
Christopher von Roretz and
Imed-Eddine Gallouzi Decoding ARE-mediated decay: is microRNA
part of the equation? . . . . . . . . . 189
Chi-Kuo Hu and
Margaret Coughlin and
Christine M. Field and
Timothy J. Mitchison Cell polarization during monopolar
cytokinesis . . . . . . . . . . . . . . 195
Ona Bloom and
Julia J. Unternaehrer and
Aimin Jiang and
Jeong-Sook Shin and
Lélia Delamarre and
Patrick Allen and
Ira Mellman Spinophilin participates in information
transfer at immunological synapses . . . 203
Fredrik Melander and
Simon Bekker-Jensen and
Jacob Falck and
Jiri Bartek and
Niels Mailand and
Jiri Lukas Phosphorylation of SDT repeats in the
MDC1 N terminus triggers retention of
NBS1 at the DNA damage--modified
chromatin . . . . . . . . . . . . . . . 213
Christoph Spycher and
Edward S. Miller and
Kelly Townsend and
Lucijana Pavic and
Nicholas A. Morrice and
Pavel Janscak and
Grant S. Stewart and
Manuel Stucki Constitutive phosphorylation of MDC1
physically links the MRE11--RAD50--NBS1
complex to damaged chromatin . . . . . . 227
Michael J. Emanuele and
Weijie Lan and
Miri Jwa and
Stephanie A. Miller and
Clarence S. M. Chan and
P. Todd Stukenberg Aurora B kinase and protein phosphatase
1 have opposing roles in modulating
kinetochore assembly . . . . . . . . . . 241
Chang-Young Jang and
Jim Wong and
Judith A. Coppinger and
Akiko Seki and
John R. Yates and
Guowei Fang DDA3 recruits microtubule depolymerase
Kif2a to spindle poles and controls
spindle dynamics and mitotic chromosome
movement . . . . . . . . . . . . . . . . 255
Dale K. Shumaker and
Liliana Solimando and
Kaushik Sengupta and
Takeshi Shimi and
Stephen A. Adam and
Antje Grunwald and
Sergei V. Strelkov and
Ueli Aebi and
M. Cristina Cardoso and
Robert D. Goldman The highly conserved nuclear lamin
Ig-fold binds to PCNA: its role in DNA
replication . . . . . . . . . . . . . . 269
Ramsey A. Saleem and
Barbara Knoblach and
Fred D. Mast and
Jennifer J. Smith and
John Boyle and
C. Melissa Dobson and
Rose Long-O'Donnell and
Richard A. Rachubinski and
John D. Aitchison Genome-wide analysis of signaling
networks regulating fatty acid--induced
gene expression and organelle biogenesis 281
Francisco Ramírez-Valle and
Steve Braunstein and
Jiri Zavadil and
Silvia C. Formenti and
Robert J. Schneider eIF4GI links nutrient sensing by mTOR to
cell proliferation and inhibition of
autophagy . . . . . . . . . . . . . . . 293
Bradley R. Pearse and
Luke Gabriel and
Ning Wang and
Daniel N. Hebert A cell-based reglucosylation assay
demonstrates the role of GT1 in the
quality control of a maturing
glycoprotein . . . . . . . . . . . . . . 309
Juying Li and
Helen L. Yin and
Junying Yuan Flightless-I regulates proinflammatory
caspases by selectively modulating
intracellular localization and caspase
activity . . . . . . . . . . . . . . . . 321
Youssef H. Zeidan and
Russell W. Jenkins and
Yusuf A. Hannun Remodeling of cellular cytoskeleton by
the acid sphingomyelinase/ceramide
pathway . . . . . . . . . . . . . . . . 335
Junji Yamauchi and
Yuki Miyamoto and
Jonah R. Chan and
Akito Tanoue ErbB2 directly activates the exchange
factor Dock7 to promote Schwann cell
migration . . . . . . . . . . . . . . . 351
Anjali K. Nath and
Rachel M. Brown and
Michael Michaud and
M. Rocio Sierra-Honigmann and
Michael Snyder and
Joseph A. Madri Leptin affects endocardial cushion
formation by modulating EMT and
migration via Akt signaling cascades . . 367
Jason J. Zoeller and
Angela McQuillan and
John Whitelock and
Shiu-Ying Ho and
Renato V. Iozzo A central function for perlecan in
skeletal muscle and cardiovascular
development . . . . . . . . . . . . . . 381
Shawdee Eshghi and
Mariette G. Vogelezang and
Richard O. Hynes and
Linda G. Griffith and
Harvey F. Lodish $ \alpha $4$ \beta $1 integrin and
erythropoietin mediate temporally
distinct steps in erythropoiesis:
integrins in red cell development . . . 395
Mitch Leslie Prions show their good side . . . . . . ??
Mitch Leslie When cells make a meal of themselves . . ??
Mitch Leslie Rac1 takes a trip . . . . . . . . . . . ??
Mitch Leslie Tag team at the telomeres . . . . . . . ??
Mitch Leslie CENP-E goes fishing for microtubules . . ??
Nicole LeBrasseur Shuffling of neuronal receptors . . . . ??
Nicole LeBrasseur Hungry cells eat ribosomes . . . . . . . ??
Nicole LeBrasseur Pseudokinase is active after all . . . . ??
Nicole LeBrasseur Channel changes customers . . . . . . . ??
Nicole LeBrasseur mTOR sends T cells on their way . . . . ??
Caitlin Sedwick Lloyd Trotman: Of mice and men, cancer,
and PTEN . . . . . . . . . . . . . . . . 402
Emma Hill and
Mike Rossner You wrote it; you own it! . . . . . . . 405
Andrew D. Steele All quiet on the neuronal front: NMDA
receptor inhibition by prion protein . . 407
Yumi Kim and
John E. Heuser and
Clare M. Waterman and
Don W. Cleveland CENP-E combines a slow, processive motor
and a flexible coiled coil to produce an
essential motile kinetochore tether . . 411
Gohta Goshima and
Mirjam Mayer and
Nan Zhang and
Nico Stuurman and
Ronald D. Vale Augmin: a protein complex required for
centrosome-independent microtubule
generation within the spindle . . . . . 421
Christopher L. de Graffenried and
Helen H. Ho and
Graham Warren Polo-like kinase is required for Golgi
and bilobe biogenesis in Trypanosoma
brucei . . . . . . . . . . . . . . . . . 431
Yan-Qing Ma and
Jun Qin and
Chuanyue Wu and
Edward F. Plow Kindlin-2 (Mig-2): a co-activator of $
\beta_3 $ integrins . . . . . . . . . . 439
Sahn-ho Kim and
Albert R. Davalos and
Seok-Jin Heo and
Francis Rodier and
Ying Zou and
Christian Beausejour and
Patrick Kaminker and
Steven M. Yannone and
Judith Campisi Telomere dysfunction and cell survival:
roles for distinct TIN2-containing
complexes . . . . . . . . . . . . . . . 447
Yueting Shang and
Tadashi Yoshida and
Brad A. Amendt and
James F. Martin and
Gary K. Owens Pitx2 is functionally important in the
early stages of vascular smooth muscle
cell differentiation . . . . . . . . . . 461
Jun Wu and
Hyekyung P. Cho and
David B. Rhee and
Dabney K. Johnson and
John Dunlap and
Yie Liu and
Yisong Wang Cdc14B depletion leads to centriole
amplification, and its overexpression
prevents unscheduled centriole
duplication . . . . . . . . . . . . . . 475
David Michaelson and
Wasif Abidi and
Daniele Guardavaccaro and
Mo Zhou and
Ian Ahearn and
Michele Pagano and
Mark R. Philips Rac1 accumulates in the nucleus during
the G2 phase of the cell cycle and
promotes cell division . . . . . . . . . 485
Taichi Hara and
Akito Takamura and
Chieko Kishi and
Shun-ichiro Iemura and
Tohru Natsume and
Jun-Lin Guan and
Noboru Mizushima FIP200, a ULK-interacting protein, is
required for autophagosome formation in
mammalian cells . . . . . . . . . . . . 497
Melissa L. Hancock and
Sarah E. Canetta and
Lorna W. Role and
David A. Talmage Presynaptic Type III Neuregulin1-ErbB
signaling targets $ \alpha $7 nicotinic
acetylcholine receptors to axons . . . . 511
Francesca Bartolini and
James B. Moseley and
Jan Schmoranzer and
Lynne Cassimeris and
Bruce L. Goode and
Gregg G. Gundersen The formin mDia2 stabilizes microtubules
independently of its actin nucleation
activity . . . . . . . . . . . . . . . . 523
Naoto Kakinuma and
Badal Chandra Roy and
Yun Zhu and
Yong Wang and
Ryoiti Kiyama Kank regulates RhoA-dependent formation
of actin stress fibers and cell
migration via 14-3-3 in PI3K--Akt
signaling . . . . . . . . . . . . . . . 537
Houman Khosravani and
Yunfeng Zhang and
Shigeki Tsutsui and
Shahid Hameed and
Christophe Altier and
Jawed Hamid and
Lina Chen and
Michelle Villemaire and
Zenobia Ali and
Frank R. Jirik and
Gerald W. Zamponi Prion protein attenuates excitotoxicity
by inhibiting NMDA receptors . . . . . . 551
Mitch Leslie Turning back the clock for Schwann cells ??
Mitch Leslie Tight junctions loosen up . . . . . . . ??
Mitch Leslie Cutting the cord . . . . . . . . . . . . ??
Mitch Leslie Ribosomes rebuffed . . . . . . . . . . . ??
Mitch Leslie RNA polymerase doesn't make deliveries ??
Richard Robinson Tumor cells share oncogenic receptors ??
Richard Robinson Too long for translocation? . . . . . . ??
Richard Robinson Signaling specifically from the endosome ??
Richard Robinson Quick flip = one-way proton trip . . . . ??
Richard Robinson Take a big gulp of pox . . . . . . . . . ??
Ruth Williams Tony Hunter: Kinase king . . . . . . . . 572
James L. Salzer Switching myelination on and off . . . . 575
Robin White and
Constantin Gonsior and
Eva-Maria Krämer-Albers and
Nadine Stöhr and
Stefan Hüttelmaier and
Jacqueline Trotter Activation of oligodendroglial Fyn
kinase enhances translation of mRNAs
transported in hnRNP A2-dependent RNA
granules . . . . . . . . . . . . . . . . 579
Ajit P. Joglekar and
David Bouck and
Ken Finley and
Xingkun Liu and
Yakun Wan and
Judith Berman and
Xiangwei He and
E. D. Salmon and
Kerry S. Bloom Molecular architecture of the
kinetochore-microtubule attachment site
is conserved between point and regional
centromeres . . . . . . . . . . . . . . 587
Thomas M. Durcan and
Elizabeth S. Halpin and
Trisha Rao and
Nicholas S. Collins and
Emily K. Tribble and
Jessica E. Hornick and
Edward H. Hinchcliffe Tektin 2 is required for central spindle
microtubule organization and the
completion of cytokinesis . . . . . . . 595
Amanda E. Bass-Zubek and
Ryan P. Hobbs and
Evangeline V. Amargo and
Nicholas J. Garcia and
Sherry N. Hsieh and
Xinyu Chen and
James K. Wahl and
Mitchell F. Denning and
Kathleen J. Green Plakophilin 2: a critical scaffold for
PKC$ \alpha $ that regulates
intercellular junction assembly . . . . 605
Meng Xu and
Peter R. Cook Similar active genes cluster in
specialized transcription factories . . 615
David B. Parkinson and
Ambily Bhaskaran and
Peter Arthur-Farraj and
Luke A. Noon and
Ashwin Woodhoo and
Alison C. Lloyd and
M. Laura Feltri and
Lawrence Wrabetz and
Axel Behrens and
Rhona Mirsky and
Kristján R. Jessen c-Jun is a negative regulator of
myelination . . . . . . . . . . . . . . 625
Hironori Kawahara and
Takao Imai and
Hiroaki Imataka and
Masafumi Tsujimoto and
Ken Matsumoto and
Hideyuki Okano Neural RNA-binding protein Musashi1
inhibits translation initiation by
competing with eIF4G for PABP . . . . . 639
Gábor Juhász and
Jahda H. Hill and
Ying Yan and
Miklós Sass and
Eric H. Baehrecke and
Jonathan M. Backer and
Thomas P. Neufeld The class III PI(3)K Vps34 promotes
autophagy and endocytosis but not TOR
signaling in \bionameDrosophila . . . . 655
Patryk Konieczny and
Peter Fuchs and
Siegfried Reipert and
Wolfram S. Kunz and
Anikó Zeöld and
Irmgard Fischer and
Denise Paulin and
Rolf Schröder and
Gerhard Wiche Myofiber integrity depends on desmin
network targeting to Z-disks and
costameres via distinct plectin isoforms 667
Le Shen and
Christopher R. Weber and
Jerrold R. Turner The tight junction protein complex
undergoes rapid and continuous molecular
remodeling at steady state . . . . . . . 683
Joanna Mathis Paterson and
Casey A. Ydenberg and
Mark D. Rose Dynamic localization of yeast Fus2p to
an expanding ring at the cell fusion
junction during mating . . . . . . . . . 697
Mitch Leslie Huntington's disease protein extends its
reach . . . . . . . . . . . . . . . . . ??
Mitch Leslie Slow synapses in schizophrenia? . . . . ??
Mitch Leslie Dieting yeast clean house . . . . . . . ??
Mitch Leslie Actin hitches a ride to the cleavage
furrow . . . . . . . . . . . . . . . . . ??
Mitch Leslie Synapse crowd control . . . . . . . . . ??
Richard Robinson rDNA silencing saves starving cells . . ??
Richard Robinson Four proteins, two new cells . . . . . . ??
Richard Robinson Sweeter tumors with EGFR . . . . . . . . ??
Richard Robinson Abundance of ITAM prevents autoimmunity ??
Richard Robinson Robo keeps axons moving . . . . . . . . ??
Ruth Williams Yasushi Saka: Stirring a melting pot of
math and morphogens . . . . . . . . . . 716
Nasser M. Rusan and
Mark Peifer Original CIN: reviewing roles for APC in
chromosome instability . . . . . . . . . 719
Katherine Minter-Dykhouse and
Irene Ward and
Michael S. Y. Huen and
Junjie Chen and
Zhenkun Lou Distinct versus overlapping functions of
MDC1 and 53BP1 in DNA damage response
and tumorigenesis . . . . . . . . . . . 727
Damien Laporte and
Bénédicte Salin and
Bertrand Daignan-Fornier and
Isabelle Sagot Reversible cytoplasmic localization of
the proteasome in quiescent yeast cells 737
Subhanjan Mondal and
Deenadayalan Bakthavatsalam and
Paul Steimle and
Berthold Gassen and
Francisco Rivero and
Angelika A. Noegel Linking Ras to myosin function: RasGEF
Q, a \bionameDictyostelium exchange
factor for RasB, affects myosin II
functions . . . . . . . . . . . . . . . 747
Panagiota Panagopoulou and
Constantinos H. Davos and
Derek J. Milner and
Emily Varela and
JoAnn Cameron and
Douglas L. Mann and
Yassemi Capetanaki Desmin mediates TNF-$ \alpha $-induced
aggregate formation and intercalated
disk reorganization in heart failure . . 761
Roger Albertson and
Jian Cao and
Tao-shih Hsieh and
William Sullivan Vesicles and actin are targeted to the
cleavage furrow via furrow microtubules
and the central spindle . . . . . . . . 777
Xiao-Wei Chen and
Ya-Qin Feng and
Chan-Juan Hao and
Xiao-Li Guo and
Xin He and
Zhi-Yong Zhou and
Ning Guo and
Hong-Ping Huang and
Wei Xiong and
Hui Zheng and
Pan-Li Zuo and
Claire Xi Zhang and
Wei Li and
Zhuan Zhou DTNBP1, a schizophrenia susceptibility
gene, affects kinetics of transmitter
release . . . . . . . . . . . . . . . . 791
Chuan-En Wang and
Hui Zhou and
John R. McGuire and
Vincenzo Cerullo and
Brendan Lee and
Shi-Hua Li and
Xiao-Jiang Li Suppression of neuropil aggregates and
neurological symptoms by an
intracellular antibody implicates the
cytoplasmic toxicity of mutant
huntingtin . . . . . . . . . . . . . . . 803
Tadayuki Shimada and
Michinori Toriyama and
Kaori Uemura and
Hiroyuki Kamiguchi and
Tadao Sugiura and
Naoki Watanabe and
Naoyuki Inagaki Shootin1 interacts with actin retrograde
flow and L1-CAM to promote axon
outgrowth . . . . . . . . . . . . . . . 817
Sergio Leal-Ortiz and
Clarissa L. Waites and
Ryan Terry-Lorenzo and
Pedro Zamorano and
Eckart D. Gundelfinger and
Craig C. Garner Piccolo modulation of Synapsin1a
dynamics regulates synaptic vesicle
exocytosis . . . . . . . . . . . . . . . 831
Nicholas C. Kappas and
Gefei Zeng and
John C. Chappell and
Joseph B. Kearney and
Surovi Hazarika and
Kimberly G. Kallianos and
Cam Patterson and
Brian H. Annex and
Victoria L. Bautch The VEGF receptor Flt-1 spatially
modulates Flk-1 signaling and blood
vessel branching . . . . . . . . . . . . 847
Nattapon Panupinthu and
Joseph T. Rogers and
Lin Zhao and
Luis Pastor Solano-Flores and
Fred Possmayer and
Stephen M. Sims and
S. Jeffrey Dixon P2X7 receptors on osteoblasts couple to
production of lysophosphatidic acid: a
signaling axis promoting osteogenesis 859
Richard Robinson Complementary receptors control RhoA . . ??
Richard Robinson Centromeres cross over, a lot . . . . . ??
Richard Robinson The mitochondrial connection . . . . . . ??
Richard Robinson A better way to see splicing partners ??
Richard Robinson Partner up to invade . . . . . . . . . . ??
Caitlin Sedwick Alison Frand: Breaking out new ideas on
molting . . . . . . . . . . . . . . . . 876
Oliver T. Fackler and
Robert Grosse Cell motility through plasma membrane
blebbing . . . . . . . . . . . . . . . . 879
Isabel Jaco and
Andrés Canela and
Elsa Vera and
Maria A. Blasco Centromere mitotic recombination in
mammalian cells . . . . . . . . . . . . 885
Anthony Tighe and
Oliver Staples and
Stephen Taylor Mps1 kinase activity restrains anaphase
during an unperturbed mitosis and
targets Mad2 to kinetochores . . . . . . 893
Lilli Winter and
Christina Abrahamsberg and
Gerhard Wiche Plectin isoform 1b mediates
mitochondrion--intermediate filament
network linkage and controls organelle
shape . . . . . . . . . . . . . . . . . 903
Jonathan E. Grim and
Michael P. Gustafson and
Roli K. Hirata and
Amanda C. Hagar and
Jherek Swanger and
Markus Welcker and
Harry C. Hwang and
Johan Ericsson and
David W. Russell and
Bruce E. Clurman Isoform- and cell cycle-dependent
substrate degradation by the Fbw7
ubiquitin ligase . . . . . . . . . . . . 913
Jonathan D. Ellis and
David Ll\`eres and
Marco Denegri and
Angus I. Lamond and
Javier F. Cáceres Spatial mapping of splicing factor
complexes involved in exon and intron
definition . . . . . . . . . . . . . . . 921
Dieter Kressler and
Daniela Roser and
Brigitte Pertschy and
Ed Hurt The AAA ATPase Rix7 powers progression
of ribosome biogenesis by stripping Nsa1
from pre-60S particles . . . . . . . . . 935
Yong Tian and
Caroline Pate and
Alberto Andreolotti and
Limin Wang and
Elaine Tuomanen and
Kelli Boyd and
Enrique Claro and
Suzanne Jackowski Cytokine secretion requires
phosphatidylcholine synthesis . . . . . 945
Xueni Li and
Mei Huang and
Huiling Zheng and
Yinyin Wang and
Fangli Ren and
Yu Shang and
Yonggong Zhai and
David M. Irwin and
Yuguang Shi and
Di Chen and
Zhijie Chang CHIP promotes Runx2 degradation and
negatively regulates osteoblast
differentiation . . . . . . . . . . . . 959
Runxiang Qiu and
Xiuyun Wang and
Alice Davy and
Chen Wu and
Kiyohito Murai and
Heying Zhang and
John G. Flanagan and
Philippe Soriano and
Qiang Lu Regulation of neural progenitor cell
state by ephrin--B . . . . . . . . . . . 973
Mika Sakurai-Yageta and
Chiara Recchi and
Gaëlle Le Dez and
Jean-Baptiste Sibarita and
Laurent Daviet and
Jacques Camonis and
Crislyn D'Souza-Schorey and
Philippe Chavrier The interaction of IQGAP1 with the
exocyst complex is required for tumor
cell invasion downstream of Cdc42 and
RhoA . . . . . . . . . . . . . . . . . . 985
Hsiao-Hui Lee and
Zee-Fen Chang Regulation of RhoA-dependent ROCKII
activation by Shp2 . . . . . . . . . . . 999
Mark D. Bass and
Mark R. Morgan and
Kirsty A. Roach and
Jeffrey Settleman and
Andrew B. Goryachev and
Martin J. Humphries p190RhoGAP is the convergence point of
adhesion signals from $ \alpha_5 \beta_1
$ integrin and syndecan-4 . . . . . . . 1013
Junghoon Ha and
Kevin W.-H. Lo and
Kenneth R. Myers and
Tiffany M. Carr and
Michael K. Humsi and
Bareza A. Rasoul and
Rosalind A. Segal and
K. Kevin Pfister A neuron-specific cytoplasmic dynein
isoform preferentially transports TrkB
signaling endosomes . . . . . . . . . . 1027
Mitch Leslie Cellular self-eating promotes
pancreatitis . . . . . . . . . . . . . . ??
Mitch Leslie Alzheimer's protein controls calcium's
ins and outs . . . . . . . . . . . . . . ??
Mitch Leslie How cells make local calls . . . . . . . ??
Mitch Leslie Mitochondrial DNA stays home . . . . . . ??
Mitch Leslie Daughter cells share duties . . . . . . ??
Ruth Williams Paul Mischel: All about brains . . . . . 1044
John W. Goss and
Derek K. Toomre Both daughter cells traffic and
exocytose membrane at the cleavage
furrow during mammalian cytokinesis . . 1047
Rajini Mudhasani and
Zhiqing Zhu and
Gyorgy Hutvagner and
Christine M. Eischen and
Stephen Lyle and
Lisa L. Hall and
Jeanne B. Lawrence and
Anthony N. Imbalzano and
Stephen N. Jones Loss of miRNA biogenesis induces
p19$^{\rm Arf}$-p53 signaling and
senescence in primary cells . . . . . . 1055
Daisuke Hashimoto and
Masaki Ohmuraya and
Masahiko Hirota and
Akitsugu Yamamoto and
Koichi Suyama and
Satoshi Ida and
Yuushi Okumura and
Etsuhisa Takahashi and
Hiroshi Kido and
Kimi Araki and
Hideo Baba and
Noboru Mizushima and
Ken-ichi Yamamura Involvement of autophagy in trypsinogen
activation within the pancreatic acinar
cells . . . . . . . . . . . . . . . . . 1065
Nadia Vadaie and
Heather Dionne and
Darowan S. Akajagbor and
Seth R. Nickerson and
Damian J. Krysan and
Paul J. Cullen Cleavage of the signaling mucin Msb2 by
the aspartyl protease Yps1 is required
for MAPK activation in yeast . . . . . . 1073
Soma Banerjee and
Stephanie Smith and
Ji-Hyun Oum and
Hung-Jiun Liaw and
Ji-Young Hwang and
Nilabja Sikdar and
Akira Motegi and
Sang Eun Lee and
Kyungjae Myung Mph1p promotes gross chromosomal
rearrangement through partial inhibition
of homologous recombination . . . . . . 1083
Daniel C. Scott and
Randy Schekman Role of Sec61p in the ER-associated
degradation of short-lived transmembrane
proteins . . . . . . . . . . . . . . . . 1095
Kim N. Green and
Angelo Demuro and
Yama Akbari and
Brian D. Hitt and
Ian F. Smith and
Ian Parker and
Frank M. LaFerla SERCA pump activity is physiologically
regulated by presenilin and regulates
amyloid $ \beta $ production . . . . . . 1107
Robert W. Gilkerson and
Eric A. Schon and
Evelyn Hernandez and
Mercy M. Davidson Mitochondrial nucleoids maintain genetic
autonomy but allow for functional
complementation . . . . . . . . . . . . 1117
Kai Chen and
Michael T. Kirber and
Hui Xiao and
Yu Yang and
John F. Keaney Regulation of ROS signal transduction by
NADPH oxidase 4 localization . . . . . . 1129
Feng-Qian Li and
Adaobi Mofunanya and
Kimberley Harris and
Ken-Ichi Takemaru Chibby cooperates with 14-3-3 to
regulate $ \beta $-catenin subcellular
distribution and signaling activity . . 1141
Yong Jik Lee and
Amy Szumlanski and
Erik Nielsen and
Zhenbiao Yang Rho-GTPase-dependent filamentous actin
dynamics coordinate vesicle targeting
and exocytosis during tip growth . . . . 1155
Barbara Zonta and
Steven Tait and
Shona Melrose and
Heather Anderson and
Sheila Harroch and
Jennifer Higginson and
Diane L. Sherman and
Peter J. Brophy Glial and neuronal isoforms of
Neurofascin have distinct roles in the
assembly of nodes of Ranvier in the
central nervous system . . . . . . . . . 1169
Sudha Kumari and
Virginia Borroni and
Ashutosh Chaudhry and
Baron Chanda and
Ramiro Massol and
Satyajit Mayor and
Francisco J. Barrantes Nicotinic acetylcholine receptor is
internalized via a Rac-dependent,
dynamin-independent endocytic pathway 1179
Mark Schramp and
Olivia Ying and
Tai Young Kim and
G. Steven Martin ERK5 promotes Src-induced podosome
formation by limiting Rho activation . . 1195
Naohide Watanabe and
Laurent Bodin and
Manjula Pandey and
Matthias Krause and
Shaun Coughlin and
Vassiliki A. Boussiotis and
Mark H. Ginsberg and
Sanford J. Shattil Mechanisms and consequences of
agonist-induced talin recruitment to
platelet integrin $ \alpha $IIb$ \beta
$3 . . . . . . . . . . . . . . . . . . . 1211
Richard Robinson Atherosclerosis Needs Shc . . . . . . . ??
Richard Robinson Sumo Keeps Lamin a in Place . . . . . . ??
Richard Robinson Pegging Mitochondrial Position . . . . . ??
Richard Robinson Nucleophosmin Mutation Is Double Trouble ??
Richard Robinson Actin and Myosin in the Mitotic Spindle ??
Caitlin Sedwick Amy Kiger: Abuzz on cell biology . . . . 4
Pier Paolo Di Fiore Playing both sides: nucleophosmin
between tumor suppression and
oncogenesis . . . . . . . . . . . . . . 7
Jacopo Meldolesi Inhibition of adipogenesis: a new job
for the ER Ca$^{2+}$ pool . . . . . . . 11
Jonathan D. Ashwell TWEAKing death . . . . . . . . . . . . . 15
Paola Bonetti and
Teresa Davoli and
Cristina Sironi and
Bruno Amati and
Pier Giuseppe Pelicci and
Emanuela Colombo Nucleophosmin and its AML-associated
mutant regulate c--Myc turnover through
Fbw7$ \gamma $ . . . . . . . . . . . . . 19
Shengjiang Tan and
Ekaterina Lyulcheva and
Jon Dean and
Daimark Bennett Mars promotes dTACC dephosphorylation on
mitotic spindles to ensure spindle
stability . . . . . . . . . . . . . . . 27
Yu-Qian Zhang and
Kevin D. Sarge Sumoylation regulates lamin A function
and is lost in lamin A mutants
associated with familial
cardiomyopathies . . . . . . . . . . . . 35
Stéphane Chiron and
Alyona Bobkova and
Haowen Zhou and
Michael P. Yaffe CLASP regulates mitochondrial
distribution in
\bionameSchizosaccharomyces pombe . . . 41
Ville O. Paavilainen and
Esko Oksanen and
Adrian Goldman and
Pekka Lappalainen Structure of the actin-depolymerizing
factor homology domain in complex with
actin . . . . . . . . . . . . . . . . . 51
Jan M. Pawlicki and
Joan A. Steitz Primary microRNA transcript retention at
sites of transcription leads to enhanced
microRNA production . . . . . . . . . . 61
Sarah Woolner and
Lori L. O'Brien and
Christiane Wiese and
William M. Bement Myosin-10 and actin filaments are
essential for mitotic spindle function 77
Dinghai Zheng and
Nader Ezzeddine and
Chyi-Ying A. Chen and
Wenmiao Zhu and
Xiangwei He and
Ann-Bin Shyu Deadenylation is prerequisite for P-body
formation and mRNA decay in mammalian
cells . . . . . . . . . . . . . . . . . 89
Eva Szabo and
Yuanyuan Qiu and
Shairaz Baksh and
Marek Michalak and
Michal Opas Calreticulin inhibits commitment to
adipocyte differentiation . . . . . . . 103
Stefan A. Paschen and
Jan G. Christian and
Juliane Vier and
Franziska Schmidt and
Axel Walch and
David M. Ojcius and
Georg Häcker Cytopathicity of \bionameChlamydia is
largely reproduced by expression of a
single chlamydial protease . . . . . . . 117
Jiefei Geng and
Misuzu Baba and
Usha Nair and
Daniel J. Klionsky Quantitative analysis of
autophagy-related protein stoichiometry
by fluorescence microscopy . . . . . . . 129
Hsu-Wen Chao and
Chen-Jei Hong and
Tzyy-Nan Huang and
Yi-Ling Lin and
Yi-Ping Hsueh SUMOylation of the MAGUK protein CASK
regulates dendritic spinogenesis . . . . 141
Tsukasa Oikawa and
Toshiki Itoh and
Tadaomi Takenawa Sequential signals toward podosome
formation in NIH-src cells . . . . . . . 157
James E. Vince and
Diep Chau and
Bernard Callus and
W. Wei-Lynn Wong and
Christine J. Hawkins and
Pascal Schneider and
Mark McKinlay and
Christopher A. Benetatos and
Stephen M. Condon and
Srinivas K. Chunduru and
George Yeoh and
Robert Brink and
David L. Vaux and
John Silke TWEAK-FN14 signaling induces lysosomal
degradation of a cIAP1--TRAF2 complex to
sensitize tumor cells to TNF$ \alpha $ 171
Yunhao Liu and
Daniel Timothy Sweet and
Mohamad Irani-Tehrani and
Nobuyo Maeda and
Ellie Tzima Shc coordinates signals from
intercellular junctions and integrins to
regulate flow-induced inflammation . . . 185
Dominique Kranz and
Christoph Dohmesen and
Matthias Dobbelstein BRCA1 and Tip60 determine the cellular
response to ultraviolet irradiation
through distinct pathways . . . . . . . 197
Mitch Leslie Untying Tube Formation . . . . . . . . . ??
Mitch Leslie Driven to the Brink by a G Protein . . . ??
Mitch Leslie New Spin on Spindle Size . . . . . . . . ??
Mitch Leslie Helping Cells Lose Their Inhibitions . . ??
Mitch Leslie Bad Breaks Don'T Doom Meiotic Cells . . ??
Caitlin Sedwick Jussi Taipale: For the love of data . . 218
Iiro Taneli Helenius and
Greg J. Beitel The first ``Slit'' is the deepest: the
secret to a hollow heart . . . . . . . . 221
Ramanujan S. Hegde and
Sang-Wook Kang The concept of translocational
regulation . . . . . . . . . . . . . . . 225
Kai-Fu Tang and
Hong Ren and
Jia Cao and
Gui-Li Zeng and
Jing Xie and
Min Chen and
Lu Wang and
Cai-Xia He Decreased Dicer expression elicits DNA
damage and up-regulation of MICA and
MICB . . . . . . . . . . . . . . . . . . 233
Edgardo Santiago-Martínez and
Nadine H. Soplop and
Rajesh Patel and
Sunita G. Kramer Repulsion by Slit and Roundabout
prevents Shotgun/E-cadherin-mediated
cell adhesion during \bionameDrosophila
heart tube lumen formation . . . . . . . 241
Caroline Medioni and
Martine Astier and
Monika Zmojdzian and
Krzysztof Jagla and
Michel Sémériva Genetic control of cell morphogenesis
during \bionameDrosophila melanogaster
cardiac tube formation . . . . . . . . . 249
Shantha K. Mahadevaiah and
Déborah Bourc'his and
Dirk G. de Rooij and
Timothy H. Bestor and
James M. A. Turner and
Paul S. Burgoyne Extensive meiotic asynapsis in mice
antagonises meiotic silencing of
unsynapsed chromatin and consequently
disrupts meiotic sex chromosome
inactivation . . . . . . . . . . . . . . 263
Ayumu Yamamoto and
Kenji Kitamura and
Daisuke Hihara and
Yukinobu Hirose and
Satoshi Katsuyama and
Yasushi Hiraoka Spindle checkpoint activation at meiosis
I advances anaphase II onset via
meiosis-specific APC/C regulation . . . 277
Alexander W. Bird and
Anthony A. Hyman Building a spindle of the correct length
in human cells requires the interaction
between TPX2 and Aurora A . . . . . . . 289
Jian Cao and
Roger Albertson and
Blake Riggs and
Christine M. Field and
William Sullivan Nuf, a Rab11 effector, maintains
cytokinetic furrow integrity by
promoting local actin polymerization . . 301
Kyle Niessen and
YangXin Fu and
Linda Chang and
Pamela A. Hoodless and
Deborah McFadden and
Aly Karsan Slug is a direct Notch target required
for initiation of cardiac cushion
cellularization . . . . . . . . . . . . 315
Maria Lombardi and
Gabriella Castoria and
Antimo Migliaccio and
Maria Vittoria Barone and
Rosina Di Stasio and
Alessandra Ciociola and
Daniela Bottero and
Hiroshi Yamaguchi and
Ettore Appella and
Ferdinando Auricchio Hormone-dependent nuclear export of
estradiol receptor and DNA synthesis in
breast cancer cells . . . . . . . . . . 327
Hao Yuan Kueh and
Guillaume T. Charras and
Timothy J. Mitchison and
William M. Brieher Actin disassembly by cofilin, coronin,
and Aip1 occurs in bursts and is
inhibited by barbed-end cappers . . . . 341
Declan J. James and
Chuenchanok Khodthong and
Judith A. Kowalchyk and
Thomas F. J. Martin Phosphatidylinositol 4,5-bisphosphate
regulates SNARE-dependent membrane
fusion . . . . . . . . . . . . . . . . . 355
Hae Won Sohn and
Pavel Tolar and
Susan K. Pierce Membrane heterogeneities in the
formation of B cell receptor--Lyn kinase
microclusters and the immune synapse . . 367
Pradipta Ghosh and
Mikel Garcia-Marcos and
Scott J. Bornheimer and
Marilyn G. Farquhar Activation of G$ \alpha $ i3 triggers
cell migration via regulation of GIV . . 381
Shinsuke Nakao and
Anna Platek and
Shinji Hirano and
Masatoshi Takeichi Contact-dependent promotion of cell
migration by the OL--protocadherin--Nap1
interaction . . . . . . . . . . . . . . 395
Richard Robinson TRPV4 shows TRPP2 the moves . . . . . . ??
Richard Robinson Two microtubules means one-way movement ??
Richard Robinson Aquaporin clears its own path . . . . . ??
Richard Robinson Mitochondria split with a calcium hit ??
Richard Robinson Egg P bodies protect maternal mRNA . . . ??
Ruth Williams Ari Helenius: viruses under surveillance 414
Michio Tomishige Activation of mitotic kinesin by
microtubule bundling . . . . . . . . . . 417
Lukas C. Kapitein and
Benjamin H. Kwok and
Joshua S. Weinger and
Christoph F. Schmidt and
Tarun M. Kapoor and
Erwin J. G. Peterman Microtubule cross-linking triggers the
directional motility of kinesin-5 . . . 421
Dhanya K. Cheerambathur and
Ingrid Brust-Mascher and
Gul Civelekoglu-Scholey and
Jonathan M. Scholey Dynamic partitioning of mitotic
kinesin-5 cross-linkers between
microtubule-bound and freely diffusing
states . . . . . . . . . . . . . . . . . 429
Michael Köttgen and
Björn Buchholz and
Miguel A. Garcia-Gonzalez and
Fruzsina Kotsis and
Xiao Fu and
Mara Doerken and
Christopher Boehlke and
Daniel Steffl and
Robert Tauber and
Tomasz Wegierski and
Roland Nitschke and
Makoto Suzuki and
Albrecht Kramer-Zucker and
Gregory G. Germino and
Terry Watnick and
Jean Prenen and
Bernd Nilius and
E. Wolfgang Kuehn and
Gerd Walz TRPP2 and TRPV4 form a polymodal sensory
channel complex . . . . . . . . . . . . 437
Toru Sasaki and
Edyta Marcon and
Tracy McQuire and
Yoichi Arai and
Peter B. Moens and
Hitoshi Okada Bat3 deficiency accelerates the
degradation of Hsp70-2/HspA2 during
spermatogenesis . . . . . . . . . . . . 449
Damian Medici and
Mohammed S. Razzaque and
Stephelynn DeLuca and
Trent L. Rector and
Bo Hou and
Kihwa Kang and
Regina Goetz and
Moosa Mohammadi and
Makoto Kuro-o and
Bjorn R. Olsen and
Beate Lanske FGF-$ 23 $--Klotho signaling stimulates
proliferation and prevents vitamin
D--induced apoptosis . . . . . . . . . . 459
Lisa Postow and
Cristina Ghenoiu and
Eileen M. Woo and
Andrew N. Krutchinsky and
Brian T. Chait and
Hironori Funabiki Ku80 removal from DNA through double
strand break--induced ubiquitylation . . 467
Dimitrios Cakouros and
Kathryn Mills and
Donna Denton and
Alicia Paterson and
Tasman Daish and
Sharad Kumar dLKR\slash SDH regulates
hormone-mediated histone arginine
methylation and transcription of cell
death genes . . . . . . . . . . . . . . 481
Jong-Sun Kang and
Gyu-Un Bae and
Min-Jeong Yi and
Youn-Joo Yang and
Ji-Eun Oh and
Giichi Takaesu and
Yi Ting Zhou and
Boon Chuan Low and
Robert S. Krauss A Cdo--Bnip--2--Cdc42 signaling pathway
regulates p38$ \alpha $ /$ \beta $ MAPK
activity and myogenic differentiation 497
Zuoren Yu and
Chenguang Wang and
Min Wang and
Zhiping Li and
Mathew C. Casimiro and
Manran Liu and
Kongming Wu and
James Whittle and
Xiaoming Ju and
Terry Hyslop and
Peter McCue and
Richard G. Pestell A cyclin D1/microRNA 17/20 regulatory
feedback loop in control of breast
cancer cell proliferation . . . . . . . 509
Claire Jacob and
Henrik Grabner and
Suzana Atanasoski and
Ueli Suter Expression and localization of Ski
determine cell type--specific TGF$ \beta
$ signaling effects on the cell cycle 519
Tongzhong Ju and
Rajindra P. Aryal and
Caleb J. Stowell and
Richard D. Cummings Regulation of protein O-glycosylation by
the endoplasmic reticulum--localized
molecular chaperone Cosmc . . . . . . . 531
Peter R. Boag and
Arzu Atalay and
Stacey Robida and
Valerie Reinke and
T. Keith Blackwell Protection of specific maternal
messenger RNAs by the P body protein
CGH-1 (Dhh1/RCK) during
\bionameCaenorhabditis elegans oogenesis 543
Scott L. Noble and
Brittany L. Allen and
Lai Kuan Goh and
Kristen Nordick and
Thomas C. Evans Maternal mRNAs are regulated by diverse
P body--related mRNP granules during
early \bionameCaenorhabditis elegans
development . . . . . . . . . . . . . . 559
Xiao-Jian Han and
Yun-Fei Lu and
Shun-Ai Li and
Taku Kaitsuka and
Yasufumi Sato and
Kazuhito Tomizawa and
Angus C. Nairn and
Kohji Takei and
Hideki Matsui and
Masayuki Matsushita CaM kinase I$ \alpha $-induced
phosphorylation of Drp1 regulates
mitochondrial morphology . . . . . . . . 573
Yumi Noda and
Saburo Horikawa and
Eiichiro Kanda and
Maho Yamashita and
Hu Meng and
Kayoko Eto and
Yuhua Li and
Michio Kuwahara and
Keiji Hirai and
Changi Pack and
Masataka Kinjo and
Shigeo Okabe and
Sei Sasaki Reciprocal interaction with G-actin and
tropomyosin is essential for aquaporin-2
trafficking . . . . . . . . . . . . . . 587
Laurence Veracini and
Valérie Simon and
Véronique Richard and
Burkhart Schraven and
Vaclav Horejsi and
Serge Roche and
Christine Benistant The Csk-binding protein PAG regulates
PDGF-induced Src mitogenic signaling via
GM1 . . . . . . . . . . . . . . . . . . 603
Mitch Leslie Stem cells stand up for themselves . . . ??
Mitch Leslie Feeling the pull . . . . . . . . . . . . ??
Mitch Leslie Young proteins cut down in their prime ??
Mitch Leslie How a cell puts itself on the menu . . . ??
Mitch Leslie Arp2\slash 3 phosphorylation kickstarts
cells . . . . . . . . . . . . . . . . . ??
Caitlin Sedwick Eran Meshorer: getting a chromatin
perspective . . . . . . . . . . . . . . 618
Anne Simonsen and
Harald Stenmark Self-eating from an ER-associated cup 621
Daniela A. Brito and
Zhenye Yang and
Conly L. Rieder Microtubules do not promote mitotic
slippage when the spindle assembly
checkpoint cannot be satisfied . . . . . 623
Ge Yang and
Lisa A. Cameron and
Paul S. Maddox and
Edward D. Salmon and
Gaudenz Danuser Regional variation of microtubule flux
reveals microtubule organization in the
metaphase meiotic spindle . . . . . . . 631
James Uniacke and
William Zerges Stress induces the assembly of RNA
granules in the chloroplast of
Chlamydomonas reinhardtii . . . . . . . 641
Lawrence L. LeClaire and
Martin Baumgartner and
Janet H. Iwasa and
R. Dyche Mullins and
Diane L. Barber Phosphorylation of the Arp2/3 complex is
necessary to nucleate actin filaments 647
Marcin Kowanetz and
Peter Lönn and
Michael Vanlandewijck and
Katarzyna Kowanetz and
Carl-Henrik Heldin and
Aristidis Moustakas TGF$ \beta $ induces SIK to negatively
regulate type I receptor kinase
signaling . . . . . . . . . . . . . . . 655
Balasubrahmanyam Medicherla and
Alfred L. Goldberg Heat shock and oxygen radicals stimulate
ubiquitin-dependent degradation mainly
of newly synthesized proteins . . . . . 663
Sungmin Song and
Huikyong Lee and
Tae-In Kam and
Mei Ling Tai and
Joo-Yong Lee and
Jee-Yeon Noh and
Sang Mi Shim and
Soo Jung Seo and
Young-Yun Kong and
Toshiyuki Nakagawa and
Chul-Woong Chung and
Deog-Young Choi and
Hammou Oubrahim and
Yong-Keun Jung E2-25K\slash Hip-2 regulates caspase-12
in ER stress-mediated A$ \beta $
neurotoxicity . . . . . . . . . . . . . 675
Elizabeth L. Axe and
Simon A. Walker and
Maria Manifava and
Priya Chandra and
H. Llewelyn Roderick and
Anja Habermann and
Gareth Griffiths and
Nicholas T. Ktistakis Autophagosome formation from membrane
compartments enriched in
phosphatidylinositol $3$-phosphate and
dynamically connected to the endoplasmic
reticulum . . . . . . . . . . . . . . . 685
Yang Cao and
Heesun Cheong and
Hui Song and
Daniel J. Klionsky In vivo reconstitution of autophagy in
\bionameSaccharomyces cerevisiae . . . . 703
Marianne Uteng and
Christian Hentrich and
Kota Miura and
Peter Bieling and
Thomas Surrey Poleward transport of Eg5 by
dynein--dynactin in \bionameXenopus
laevis egg extract spindles . . . . . . 715
Manojkumar Valiyaveettil and
Amber A. Bentley and
Priya Gursahaney and
Rajaa Hussien and
Ritu Chakravarti and
Nina Kureishy and
Soren Prag and
Josephine C. Adams Novel role of the muskelin--RanBP9
complex as a nucleocytoplasmic mediator
of cell morphology regulation . . . . . 727
Gustavo V. Mallo and
Marianela Espina and
Adam C. Smith and
Mauricio R. Terebiznik and
Ainel Alemán and
B. Brett Finlay and
Lucia E. Rameh and
Sergio Grinstein and
John H. Brumell SopB promotes phosphatidylinositol
$3$-phosphate formation on Salmonella
vacuoles by recruiting Rab5 and Vps34 741
Yi-Jen Chiu and
Elena McBeath and
Keigi Fujiwara Mechanotransduction in an extracted cell
model: Fyn drives stretch- and
flow-elicited PECAM-1 phosphorylation 753
Cedric Espenel and
Emmanuel Margeat and
Patrice Dosset and
Cécile Arduise and
Christian Le Grimellec and
Catherine A. Royer and
Claude Boucheix and
Eric Rubinstein and
Pierre-Emmanuel Milhiet Single-molecule analysis of CD9 dynamics
and partitioning reveals multiple modes
of interaction in the tetraspanin web 765
Harvey W. Smith and
Pierfrancesco Marra and
Christopher J. Marshall uPAR promotes formation of the
p130Cas--Crk complex to activate Rac
through DOCK180 . . . . . . . . . . . . 777
Timothy A. Springer and
Jianghai Zhu and
Tsan Xiao Structural basis for distinctive
recognition of fibrinogen $ \gamma $C
peptide by the platelet integrin $
\alpha_{IIb} $ $ \beta_3 $ . . . . . . . 791
Alana M. O'Reilly and
Hsiu-Hsiang Lee and
Michael A. Simon Integrins control the positioning and
proliferation of follicle stem cells in
the \bionameDrosophila ovary . . . . . . 801
Richard Robinson and
Ruth Williams Kick out the reticulons to close the
envelope . . . . . . . . . . . . . . . . ??
Richard Robinson and
Ruth Williams Better binding with a flick of the tail ??
Richard Robinson and
Ruth Williams Vesicles roar, and don't collapse . . . ??
Richard Robinson and
Ruth Williams A weak signaler gets in close . . . . . ??
Richard Robinson and
Ruth Williams SRC1, central to the nuclear periphery ??
Ruth Williams Bruce Alberts: Education, education,
education . . . . . . . . . . . . . . . 820
Marisa P. McShane and
Marino Zerial Survival of the weakest: signaling aided
by endosomes . . . . . . . . . . . . . . 823
Yi Hao and
Ian G. Macara Regulation of chromatin binding by a
conformational switch in the tail of the
Ran exchange factor RCC1 . . . . . . . . 827
Blaine Bisel and
Yanzhuang Wang and
Jen-Hsuan Wei and
Yi Xiang and
Danming Tang and
Miguel Miron-Mendoza and
Shin-ichiro Yoshimura and
Nobuhiro Nakamura and
Joachim Seemann ERK regulates Golgi and centrosome
orientation towards the leading edge
through GRASP65 . . . . . . . . . . . . 837
Rita L. Nokes and
Ian C. Fields and
Ruth N. Collins and
Heike Fölsch Rab13 regulates membrane trafficking
between TGN and recycling endosomes in
polarized epithelial cells . . . . . . . 845
Stéphanie Kermorgant and
Peter J. Parker Receptor trafficking controls weak
signal delivery: a strategy used by
c--Met for STAT3 nuclear accumulation 855
Yu Ding and
Ying Xi and
Ting Chen and
Ji-yong Wang and
Dong-lei Tao and
Zhi-Li Wu and
Yi-ping Li and
Chen Li and
Rong Zeng and
Lin Li Caprin-2 enhances canonical Wnt
signaling through regulating LRP5/6
phosphorylation . . . . . . . . . . . . 865
Ethel Queralt and
Frank Uhlmann Separase cooperates with Zds1 and Zds2
to activate Cdc14 phosphatase in early
anaphase . . . . . . . . . . . . . . . . 873
Jianjun Sun and
Laila Smith and
Alexander Armento and
Wu-Min Deng Regulation of the endocycle/gene
amplification switch by Notch and
ecdysone signaling . . . . . . . . . . . 885
Stefanie E. Grund and
Tamás Fischer and
Ghislain G. Cabal and
Oreto Antúnez and
José E. Pérez-Ortín and
Ed Hurt The inner nuclear membrane protein Src1
associates with subtelomeric genes and
alters their regulated gene expression 897
Daniel J. Anderson and
Martin W. Hetzer Reshaping of the endoplasmic reticulum
limits the rate for nuclear envelope
formation . . . . . . . . . . . . . . . 911
Mikhail Bogdanov and
Jun Xie and
Phil Heacock and
William Dowhan To flip or not to flip: lipid--protein
charge interactions are a determinant of
final membrane protein topology . . . . 925
Steven M. Claypool and
Yavuz Oktay and
Pinmanee Boontheung and
Joseph A. Loo and
Carla M. Koehler Cardiolipin defines the interactome of
the major ADP/ATP carrier protein of the
mitochondrial inner membrane . . . . . . 937
Noa B. Martín-Cófreces and
Javier Robles-Valero and
J. Román Cabrero and
María Mittelbrunn and
Mónica Gordón-Alonso and
Ching-Hwa Sung and
Balbino Alarcón and
Jesús Vázquez and
Francisco Sánchez-Madrid MTOC translocation modulates IS
formation and controls sustained T cell
signaling . . . . . . . . . . . . . . . 951
David A. Dansereau and
Paul Lasko RanBPM regulates cell shape,
arrangement, and capacity of the female
germline stem cell niche in
\bionameDrosophila melanogaster . . . . 963
Hongxia Ren and
Ping Yin and
Cunming Duan IGFBP-5 regulates muscle cell
differentiation by binding to IGF--II
and switching on the IGF--II
auto-regulation loop . . . . . . . . . . 979
Michele A. West and
Alan R. Prescott and
Kui Ming Chan and
Zhongjun Zhou and
Stefan Rose-John and
Jürgen Scheller and
Colin Watts TLR ligand--induced podosome disassembly
in dendritic cells is ADAM17 dependent 993
Jaroslaw Kasprowicz and
Sabine Kuenen and
Katarzyna Miskiewicz and
Ron L. P. Habets and
Liesbet Smitz and
Patrik Verstreken Inactivation of clathrin heavy chain
inhibits synaptic recycling but allows
bulk membrane uptake . . . . . . . . . . 1007
Artur Llobet and
Minnie Wu and
Leon Lagnado The mouth of a dense-core vesicle opens
and closes in a concerted action
regulated by calcium and amphiphysin . . 1017
Mitch Leslie Timing the breakdown . . . . . . . . . . ??
Mitch Leslie Rab(ble) rouser . . . . . . . . . . . . ??
Mitch Leslie Rules of gene attraction . . . . . . . . ??
Mitch Leslie Laminin reaches across the synapse . . . ??
Mitch Leslie Pumping up caveolae . . . . . . . . . . ??
Ruth Williams Kris DeMali: Fixed on cell adhesion . . 1032
Jeanne B. Lawrence and
Christine M. Clemson Gene associations: true romance or
chance meeting in a nuclear
neighborhood? . . . . . . . . . . . . . 1035
Richard A. Kahn and
Elspeth Bruford and
Hiroki Inoue and
John M. Logsdon and
Zhongzhen Nie and
Richard T. Premont and
Paul A. Randazzo and
Masanobu Satake and
Anne B. Theibert and
Maria L. Zapp and
Dan Cassel Consensus nomenclature for the human
ArfGAP domain-containing proteins . . . 1039
Dileep Varma and
Pascale Monzo and
Stephanie A. Stehman and
Richard B. Vallee Direct role of dynein motor in stable
kinetochore-microtubule attachment,
orientation, and alignment . . . . . . . 1045
Elizabeth M. Wilson-Kubalek and
Iain M. Cheeseman and
Craig Yoshioka and
Arshad Desai and
Ronald A. Milligan Orientation and structure of the Ndc80
complex on the microtubule lattice . . . 1055
Sachin Hebbar and
Mariano T. Mesngon and
Aimee M. Guillotte and
Bhavim Desai and
Ramses Ayala and
Deanna S. Smith Lis1 and Ndel1 influence the timing of
nuclear envelope breakdown in neural
stem cells . . . . . . . . . . . . . . . 1063
Gun-Hwa Kim and
Jung-Hyun Her and
Jin-Kwan Han Ryk cooperates with Frizzled 7 to
promote Wnt11-mediated endocytosis and
is essential for \bionameXenopus laevis
convergent extension movements . . . . . 1073
Jill M. Brown and
Joanne Green and
Ricardo Pires das Neves and
Helen A. C. Wallace and
Andrew J. H. Smith and
Jim Hughes and
Nicki Gray and
Steve Taylor and
William G. Wood and
Douglas R. Higgs and
Francisco J. Iborra and
Veronica J. Buckle Association between active genes occurs
at nuclear speckles and is modulated by
chromatin environment . . . . . . . . . 1083
Miri Jwa and
Jae-hyun Kim and
Clarence S. M. Chan Regulation of Sli15/INCENP, kinetochore,
and Cdc14 phosphatase functions by the
ribosome biogenesis protein Utp7 . . . . 1099
An-Chi Tien and
Akhila Rajan and
Karen L. Schulze and
Hyung Don Ryoo and
Melih Acar and
Hermann Steller and
Hugo J. Bellen Ero1L, a thiol oxidase, is required for
Notch signaling through cysteine bridge
formation of the Lin12-Notch repeats in
\bionameDrosophila melanogaster . . . . 1113
Ying-Chen Claire Hou and
Suganthi Chittaranjan and
Sharon González Barbosa and
Kimberly McCall and
Sharon M. Gorski Effector caspase Dcp-1 and IAP protein
Bruce regulate starvation-induced
autophagy during \bionameDrosophila
melanogaster oogenesis . . . . . . . . . 1127
Christopher L. Brett and
Rachael L. Plemel and
Braden T. Lobingier and
Marissa Vignali and
Stanley Fields and
Alexey J. Merz Efficient termination of vacuolar Rab
GTPase signaling requires coordinated
action by a GAP and a protein kinase . . 1141
Ting Cai and
Haojie Wang and
Yiliang Chen and
Lijun Liu and
William T. Gunning and
Luis Eduardo M. Quintas and
Zi-Jian Xie Regulation of caveolin-1 membrane
trafficking by the Na/K--ATPase . . . . 1153
Haibo Wang and
Ambika Tewari and
Steven Einheber and
James L. Salzer and
Carmen V. Melendez-Vasquez Myosin II has distinct functions in PNS
and CNS myelin sheath formation . . . . 1171
Vsevolod Bodrikov and
Vladimir Sytnyk and
Iryna Leshchyns'ka and
Jeroen den Hertog and
Melitta Schachner NCAM induces CaMKII$ \alpha $-mediated
RPTP$ \alpha $ phosphorylation to
enhance its catalytic activity and
neurite outgrowth . . . . . . . . . . . 1185
Hiroshi Nishimune and
Gregorio Valdez and
George Jarad and
Casey L. Moulson and
Ulrich Müller and
Jeffrey H. Miner and
Joshua R. Sanes Laminins promote postsynaptic maturation
by an autocrine mechanism at the
neuromuscular junction . . . . . . . . . 1201
Mariko Hirano and
Shigeru Hashimoto and
Shigenobu Yonemura and
Hisataka Sabe and
Shinichi Aizawa EPB41L5 functions to
post-transcriptionally regulate cadherin
and integrin during
epithelial--mesenchymal transition . . . 1217
Jeffrey C. Nolz and
Lucas P. Nacusi and
Colin M. Segovis and
Ricardo B. Medeiros and
Jason S. Mitchell and
Yoji Shimizu and
Daniel D. Billadeau The WAVE2 complex regulates T cell
receptor signaling to integrins via Abl-
and CrkL--C3G-mediated activation of
Rap1 . . . . . . . . . . . . . . . . . . 1231
Richard Robinson No waiting at the nuclear pore complex ??
Richard Robinson No stretch for spindle assembly
checkpoint . . . . . . . . . . . . . . . ??
Richard Robinson Autophagy inhibitors deliver a knock-out
blow . . . . . . . . . . . . . . . . . . ??
Richard Robinson Tre1 says when, and where, to go . . . . ??
Richard Robinson Random, fast, and out of control . . . . ??
Ruth Williams Tae Hoon Kim: Knows his boundaries . . . 4
Beatrice Maria Filippi and
Dario R. Alessi Novel role for the LKB1 pathway in
controlling monocarboxylate fuel
transporters . . . . . . . . . . . . . . 7
Cholsoon Jang and
Gina Lee and
Jongkyeong Chung LKB1 induces apical trafficking of
Silnoon, a monocarboxylate transporter,
in \bionameDrosophila melanogaster . . . 11
Masahiko Sugimoto and
Akihito Inoko and
Takashi Shiromizu and
Masanori Nakayama and
Peng Zou and
Shigenobu Yonemura and
Yuko Hayashi and
Ichiro Izawa and
Mikio Sasoh and
Yukitaka Uji and
Kozo Kaibuchi and
Tohru Kiyono and
Masaki Inagaki The keratin-binding protein Albatross
regulates polarization of epithelial
cells . . . . . . . . . . . . . . . . . 19
Christopher B. O'Connell and
Jadranka Lon\vcarek and
Polla Hergert and
Antonis Kourtidis and
Douglas S. Conklin and
Alexey Khodjakov The spindle assembly checkpoint is
satisfied in the absence of
interkinetochore tension during mitosis
with unreplicated genomes . . . . . . . 29
Xuan Wang and
H. Amalia Pasolli and
Trevor Williams and
Elaine Fuchs AP-2 factors act in concert with Notch
to orchestrate terminal differentiation
in skin epidermis . . . . . . . . . . . 37
Kristopher J. Stanya and
Yu Liu and
Anthony R. Means and
Hung-Ying Kao Cdk2 and Pin1 negatively regulate the
transcriptional corepressor SMRT . . . . 49
Anne Royou and
Derek McCusker and
Douglas R. Kellogg and
William Sullivan Grapes(Chk1) prevents nuclear CDK1
activation by delaying cyclin B nuclear
accumulation . . . . . . . . . . . . . . 63
Thomas Dange and
David Grünwald and
Antje Grünwald and
Reiner Peters and
Ulrich Kubitscheck Autonomy and robustness of translocation
through the nuclear pore complex: a
single-molecule study . . . . . . . . . 77
Fei Wang and
Birgit Agne and
Felix Kessler and
Danny J. Schnell The role of GTP binding and hydrolysis
at the atToc159 preprotein receptor
during protein import into chloroplasts 87
Michael Degtyarev and
Ann De Mazi\`ere and
Christine Orr and
Jie Lin and
Brian B. Lee and
Janet Y. Tien and
Wei W. Prior and
Suzanne van Dijk and
Hong Wu and
Daniel C. Gray and
David P. Davis and
Howard M. Stern and
Lesley J. Murray and
Klaus P. Hoeflich and
Judith Klumperman and
Lori S. Friedman and
Kui Lin Akt inhibition promotes autophagy and
sensitizes PTEN-null tumors to
lysosomotropic agents . . . . . . . . . 101
Chiara Collesi and
Lorena Zentilin and
Gianfranco Sinagra and
Mauro Giacca Notch1 signaling stimulates
proliferation of immature cardiomyocytes 117
Víctor M. Campa and
Raquel Gutiérrez-Lanza and
Fabio Cerignoli and
Ramón Díaz-Trelles and
Brandon Nelson and
Toshiya Tsuji and
Maria Barcova and
Wei Jiang and
Mark Mercola Notch activates cell cycle reentry and
progression in quiescent cardiomyocytes 129
Patrick T. Caswell and
May Chan and
Andrew J. Lindsay and
Mary W. McCaffrey and
David Boettiger and
Jim C. Norman Rab-coupling protein coordinates
recycling of $ \alpha $5$ \beta $1
integrin and EGFR1 to promote cell
migration in $3$D microenvironments . . 143
Prabhat S. Kunwar and
Hiroko Sano and
Andrew D. Renault and
Vitor Barbosa and
Naoyuki Fuse and
Ruth Lehmann Tre1 GPCR initiates germ cell
transepithelial migration by regulating
\bionameDrosophila melanogaster
E-cadherin . . . . . . . . . . . . . . . 157
Artur Llobet and
Minnie Wu and
Leon Lagnado The mouth of a dense-core vesicle opens
and closes in a concerted action
regulated by calcium and amphiphysin . . 169
Ruth Williams Flavivirus reveals its access code . . . ??
Ruth Williams IP blacklist . . . . . . . . . . . . . . ??
Ruth Williams APC ain't always necessary for axons . . ??
Ruth Williams Astrocyte's clean up job . . . . . . . . ??
Ruth Williams Microdomain switching is a bad move for
APP . . . . . . . . . . . . . . . . . . ??
Caitlin Sedwick Qing Zhong: Scoring a slam dunk on the
autophagy court . . . . . . . . . . . . 174
Stephen C. Harrison The pH sensor for flavivirus membrane
fusion . . . . . . . . . . . . . . . . . 177
Alex Engel and
Peter Walter Membrane lysis during biological
membrane fusion: collateral damage by
misregulated fusion machines . . . . . . 181
Takaharu G. Yamamoto and
Sonoko Watanabe and
Anthony Essex and
Risa Kitagawa SPDL-1 functions as a kinetochore
receptor for MDF-1 in
\bionameCaenorhabditis elegans . . . . . 187
Diana Stojanovski and
Dusanka Milenkovic and
Judith M. Müller and
Kipros Gabriel and
Agnes Schulze-Specking and
Michael J. Baker and
Michael T. Ryan and
Bernard Guiard and
Nikolaus Pfanner and
Agnieszka Chacinska Mitochondrial protein import: precursor
oxidation in a ternary complex with
disulfide carrier and sulfhydryl oxidase 195
Nasser M. Rusan and
Kathryn Akong and
Mark Peifer Putting the model to the test: are APC
proteins essential for neuronal
polarity, axon outgrowth, and axon
targeting? . . . . . . . . . . . . . . . 203
Matteo Bergami and
Spartaco Santi and
Elena Formaggio and
Cinzia Cagnoli and
Claudia Verderio and
Robert Blum and
Benedikt Berninger and
Michela Matteoli and
Marco Canossa Uptake and recycling of pro--BDNF for
transmitter-induced secretion by
cortical astrocytes . . . . . . . . . . 213
Laura Trinkle-Mulcahy and
Séverine Boulon and
Yun Wah Lam and
Roby Urcia and
François-Michel Boisvert and
Franck Vandermoere and
Nick A. Morrice and
Sam Swift and
Ulrich Rothbauer and
Heinrich Leonhardt and
Angus Lamond Identifying specific protein interaction
partners using quantitative mass
spectrometry and bead proteomes . . . . 223
Annapaola Franchitto and
Livia Maria Pirzio and
Ennio Prosperi and
Orazio Sapora and
Margherita Bignami and
Pietro Pichierri Replication fork stalling in
WRN-deficient cells is overcome by
prompt activation of a MUS81-dependent
pathway . . . . . . . . . . . . . . . . 241
Haiyang Li and
Adayabalam S. Balajee and
Tao Su and
Bo Cen and
Tom K. Hei and
I. Bernard Weinstein The HINT1 tumor suppressor regulates
both $ \gamma $-H2AX and ATM in response
to DNA damage . . . . . . . . . . . . . 253
Evan C. Osmundson and
Dipankar Ray and
Finola E. Moore and
Qingshen Gao and
Gerald H. Thomsen and
Hiroaki Kiyokawa The HECT E3 ligase Smurf2 is required
for Mad2-dependent spindle assembly
checkpoint . . . . . . . . . . . . . . . 267
Zuojun Yue and
Ana Carvalho and
Zhenjie Xu and
Xuemei Yuan and
Stefano Cardinale and
Susana Ribeiro and
Fan Lai and
Hiromi Ogawa and
Elisabet Gudmundsdottir and
Reto Gassmann and
Ciaran G. Morrison and
Sandrine Ruchaud and
William C. Earnshaw Deconstructing Survivin: comprehensive
genetic analysis of Survivin function by
conditional knockout in a vertebrate
cell line . . . . . . . . . . . . . . . 279
Stephen C. Tovey and
Skarlatos G. Dedos and
Emily J. A. Taylor and
Jarrod E. Church and
Colin W. Taylor Selective coupling of type 6 adenylyl
cyclase with type 2 IP$_3$ receptors
mediates direct sensitization of IP$_3$
receptors by cAMP . . . . . . . . . . . 297
Noveera T. Ahmed and
Chunlei Gao and
Ben F. Lucker and
Douglas G. Cole and
David R. Mitchell ODA16 aids axonemal outer row dynein
assembly through an interaction with the
intraflagellar transport machinery . . . 313
Toshiaki Sakisaka and
Yasunori Yamamoto and
Sumiko Mochida and
Michiko Nakamura and
Kouki Nishikawa and
Hiroyoshi Ishizaki and
Miki Okamoto-Tanaka and
Jun Miyoshi and
Yoshinori Fujiyoshi and
Toshiya Manabe and
Yoshimi Takai Dual inhibition of SNARE complex
formation by tomosyn ensures controlled
neurotransmitter release . . . . . . . . 323
Takashi Sakurai and
Kumi Kaneko and
Misako Okuno and
Koji Wada and
Taku Kashiyama and
Hideaki Shimizu and
Takumi Akagi and
Tsutomu Hashikawa and
Nobuyuki Nukina Membrane microdomain switching: a
regulatory mechanism of amyloid
precursor protein processing . . . . . . 339
Richard Fritz and
Karin Stiasny and
Franz X. Heinz Identification of specific histidines as
pH sensors in flavivirus membrane fusion 353
Ira Mellman George E. Palade, Cell Biology and The
JCB . . . . . . . . . . . . . . . . . . 365
Richard Robinson No direction? Join the crowd . . . . . . ??
Richard Robinson Sarcospan, a little protein for a big
problem . . . . . . . . . . . . . . . . ??
Richard Robinson BBB building . . . . . . . . . . . . . . ??
Richard Robinson If you build it, leukocytes will come
(in) . . . . . . . . . . . . . . . . . . ??
Richard Robinson Microtubule failure assists cleavage
success . . . . . . . . . . . . . . . . ??
Mike Rossner Heather Joseph: Getting the message
across . . . . . . . . . . . . . . . . . 368
Paul Polakis Formation of the blood--brain barrier:
Wnt signaling seals the deal . . . . . . 371
Klaus Ley and
Hong Zhang Dances with leukocytes: how
tetraspanin-enriched microdomains
assemble to form endothelial adhesive
platforms . . . . . . . . . . . . . . . 375
Julie A. Jonassen and
Jovenal San Agustin and
John A. Follit and
Gregory J. Pazour Deletion of IFT20 in the mouse kidney
causes misorientation of the mitotic
spindle and cystic kidney disease . . . 377
Jennifer M. Leonard and
Hong Ye and
Cynthia Wetmore and
Larry M. Karnitz Sonic Hedgehog signaling impairs
ionizing radiation--induced checkpoint
activation and induces genomic
instability . . . . . . . . . . . . . . 385
Ravid Shechter and
Ayal Ronen and
Asya Rolls and
Anat London and
Sharon Bakalash and
Michael J. Young and
Michal Schwartz Toll-like receptor 4 restricts retinal
progenitor cell proliferation . . . . . 393
Kossay Zaoui and
Stéphane Honoré and
Daniel Isnardon and
Diane Braguer and
Ali Badache Memo-RhoA-mDia1 signaling controls
microtubules, the actin network, and
adhesion site formation in migrating
cells . . . . . . . . . . . . . . . . . 401
Stefan Liebner and
Monica Corada and
Thorsten Bangsow and
Jane Babbage and
Andrea Taddei and
Cathrin J. Czupalla and
Marco Reis and
Angelina Felici and
Hartwig Wolburg and
Marcus Fruttiger and
Makoto M. Taketo and
Harald von Melchner and
Karl Heinz Plate and
Holger Gerhardt and
Elisabetta Dejana Wnt\slash $ \beta $-catenin signaling
controls development of the blood--brain
barrier . . . . . . . . . . . . . . . . 409
Angela K. Peter and
Jamie L. Marshall and
Rachelle H. Crosbie Sarcospan reduces dystrophic pathology:
stabilization of the
utrophin--glycoprotein complex . . . . . 419
Yohannes A. Mebratu and
Burton F. Dickey and
Chris Evans and
Yohannes Tesfaigzi The BH3-only protein Bik/Blk/Nbk
inhibits nuclear translocation of
activated ERK1/2 to mediate IFN$ \gamma
$-induced cell death . . . . . . . . . . 429
J. Ross Buchan and
Denise Muhlrad and
Roy Parker P bodies promote stress granule assembly
in \bionameSaccharomyces cerevisiae . . 441
Victoria E. Foe and
George von Dassow Stable and dynamic microtubules
coordinately shape the myosin activation
zone during cytokinetic furrow formation 457
Garrett M. Odell and
Victoria E. Foe An agent-based model contrasts opposite
effects of dynamic and stable
microtubules on cleavage furrow
positioning . . . . . . . . . . . . . . 471
Sheila A. Baker and
Mohammad Haeri and
Peter Yoo and
Sidney M. Gospe and
Nikolai P. Skiba and
Barry E. Knox and
Vadim Y. Arshavsky The outer segment serves as a default
destination for the trafficking of
membrane proteins in photoreceptors . . 485
Sophia Semerdjieva and
Barry Shortt and
Emma Maxwell and
Sukhdeep Singh and
Paul Fonarev and
Jonathan Hansen and
Giampietro Schiavo and
Barth D. Grant and
Elizabeth Smythe Coordinated regulation of AP2 uncoating
from clathrin-coated vesicles by rab5
and hRME-6 . . . . . . . . . . . . . . . 499
Raul Rojas and
Thijs van Vlijmen and
Gonzalo A. Mardones and
Yogikala Prabhu and
Adriana L. Rojas and
Shabaz Mohammed and
Albert J. R. Heck and
Graça Raposo and
Peter van der Sluijs and
Juan S. Bonifacino Regulation of retromer recruitment to
endosomes by sequential action of Rab5
and Rab7 . . . . . . . . . . . . . . . . 513
Olga Barreiro and
Moreno Zamai and
María Yáñez-Mó and
Emilio Tejera and
Pedro López-Romero and
Peter N. Monk and
Enrico Gratton and
Valeria R. Caiolfa and
Francisco Sánchez-Madrid Endothelial adhesion receptors are
recruited to adherent leukocytes by
inclusion in preformed tetraspanin
nanoplatforms . . . . . . . . . . . . . 527
Miguel Vicente-Manzanares and
Margaret A. Koach and
Leanna Whitmore and
Marcelo L. Lamers and
Alan F. Horwitz Segregation and activation of myosin IIB
creates a rear in migrating cells . . . 543
Paolo Giacobini and
Andrea Messina and
Francesca Morello and
Nicoletta Ferraris and
Simona Corso and
Junia Penachioni and
Silvia Giordano and
Luca Tamagnone and
Aldo Fasolo Semaphorin $4$D regulates gonadotropin
hormone-releasing hormone-1 neuronal
migration through PlexinB1--Met complex 555
Mitch Leslie Cdc42 turns the spindle . . . . . . . . ??
Mitch Leslie A get-together for caspases . . . . . . ??
Mitch Leslie Axons lose their identity . . . . . . . ??
Mitch Leslie Uniting to save cancer cells . . . . . . ??
Mitch Leslie DNA healer . . . . . . . . . . . . . . . ??
Caitlin Sedwick Rebecca Heald: Passionate about cycles 570
Mike Rossner A false sense of security . . . . . . . 573
Terry Lechler Limiting lumens: a new role for Cdc42 575
Luca Scorrano Caspase-8 goes cardiolipin: a new
platform to provide mitochondria with
microdomains of apoptotic signals? . . . 579
Clifford P. Brangwynne and
Gijsje H. Koenderink and
Frederick C. MacKintosh and
David A. Weitz Cytoplasmic diffusion: molecular motors
mix it up . . . . . . . . . . . . . . . 583
Chawon Yun and
Yonggang Wang and
Debaditya Mukhopadhyay and
Peter Backlund and
Nagamalleswari Kolli and
Alfred Yergey and
Keith D. Wilkinson and
Mary Dasso Nucleolar protein B23/nucleophosmin
regulates the vertebrate SUMO pathway
through SENP3 and SENP5 proteases . . . 589
Rebecca Aucott and
Jörn Bullwinkel and
Yang Yu and
Wei Shi and
Mustafa Billur and
Jeremy P. Brown and
Ursula Menzel and
Dimitris Kioussis and
Guozheng Wang and
Ingrid Reisert and
Jörg Weimer and
Raj K. Pandita and
Girdhar G. Sharma and
Tej K. Pandita and
Reinald Fundele and
Prim B. Singh HP1-$ \beta $ is required for
development of the cerebral neocortex
and neuromuscular junctions . . . . . . 597
Rita Sinka and
Alison K. Gillingham and
Vangelis Kondylis and
Sean Munro Golgi coiled-coil proteins contain
multiple binding sites for Rab family G
proteins . . . . . . . . . . . . . . . . 607
Michael Wagenbach and
Sarah Domnitz and
Linda Wordeman and
Jeremy Cooper A kinesin-13 mutant catalytically
depolymerizes microtubules in ADP . . . 617
Aron B. Jaffe and
Noriko Kaji and
Joanne Durgan and
Alan Hall Cdc42 controls spindle orientation to
position the apical surface during
epithelial morphogenesis . . . . . . . . 625
Kristian L. Hedstrom and
Yasuhiro Ogawa and
Matthew N. Rasband AnkyrinG is required for maintenance of
the axon initial segment and neuronal
polarity . . . . . . . . . . . . . . . . 635
Shin-ichiro Hiraga and
Sotirios Botsios and
Anne D. Donaldson Histone H3 lysine 56 acetylation by
Rtt109 is crucial for chromosome
positioning . . . . . . . . . . . . . . 641
José María González and
Ana Navarro-Puche and
Berta Casar and
Piero Crespo and
Vicente Andrés Fast regulation of AP-1 activity through
interaction of lamin A/C, ERK1/2, and
c--Fos at the nuclear envelope . . . . . 653
Haomin Huang and
James Hittle and
Francesca Zappacosta and
Roland S. Annan and
Avram Hershko and
Timothy J. Yen Phosphorylation sites in BubR1 that
regulate kinetochore attachment,
tension, and mitotic exit . . . . . . . 667
Francois Gonzalvez and
Zachary T. Schug and
Riekelt H. Houtkooper and
Elaine D. MacKenzie and
David G. Brooks and
Ronald J. A. Wanders and
Patrice X. Petit and
Frédéric M. Vaz and
Eyal Gottlieb Cardiolipin provides an essential
activating platform for caspase-8 on
mitochondria . . . . . . . . . . . . . . 681
Paloma Ordóñez-Morán and
María Jesús Larriba and
Héctor G. Pálmer and
Ruth A. Valero and
Antonio Barbáchano and
Mireia Duñach and
Antonio García de Herreros and
Carlos Villalobos and
María Teresa Berciano and
Miguel Lafarga and
Alberto Muñoz RhoA--ROCK and p38MAPK--MSK1 mediate
vitamin D effects on gene expression,
phenotype, and Wnt pathway in colon
cancer cells . . . . . . . . . . . . . . 697
XiaoDong Huang and
Diana Wu and
Hua Jin and
Dwayne Stupack and
Jean Y. J. Wang Induction of cell retraction by the
combined actions of Abl--CrkII and
Rho--ROCK1 signaling . . . . . . . . . . 711
Carolin Weimer and
Rainer Beck and
Priska Eckert and
Ingeborg Reckmann and
Jörg Moelleken and
Britta Brügger and
Felix Wieland Differential roles of ArfGAP1, ArfGAP2,
and ArfGAP3 in COPI trafficking . . . . 725
Edwin Soto and
Masahiro Yanagisawa and
Laura A. Marlow and
John A. Copland and
Edith A. Perez and
Panos Z. Anastasiadis p120 catenin induces opposing effects on
tumor cell growth depending on
E-cadherin expression . . . . . . . . . 737
Caitlin Sedwick Claudin 11 stops the leaks . . . . . . . ??
Caitlin Sedwick Parkin cleans house . . . . . . . . . . ??
Caitlin Sedwick \bionameDictyostelium cells lay a
breadcrumb trail . . . . . . . . . . . . ??
Caitlin Sedwick Cofilin activity is a total coincidence ??
Caitlin Sedwick Dynein gives the ``all clear'' . . . . . ??
Ruth Williams Brett Lindenbach: Deconstructing and
reconstructing hepatitis C . . . . . . . 754
Heidi M. McBride Parkin mitochondria in the autophagosome 757
John J. Skinner and
Stacey Wood and
James Shorter and
S. Walter Englander and
Ben E. Black The Mad2 partial unfolding model:
regulating mitosis through Mad2
conformational switching . . . . . . . . 761
Oliver Mortusewicz and
Wera Roth and
Na Li and
M. Cristina Cardoso and
Michael Meisterernst and
Heinrich Leonhardt Recruitment of RNA polymerase II
cofactor PC4 to DNA damage sites . . . . 769
Jeremy A. Daniel and
Manuela Pellegrini and
Ji-Hoon Lee and
Tanya T. Paull and
Lionel Feigenbaum and
André Nussenzweig Multiple autophosphorylation sites are
dispensable for murine ATM activation in
vivo . . . . . . . . . . . . . . . . . . 777
Tsui-Han Loo and
Mohan Balasubramanian \bionameSchizosaccharomyces pombe
Pak-related protein, Pak1p/Orb2p,
phosphorylates myosin regulatory light
chain to inhibit cytokinesis . . . . . . 785
Derek Narendra and
Atsushi Tanaka and
Der-Fen Suen and
Richard J. Youle Parkin is recruited selectively to
impaired mitochondria and promotes their
autophagy . . . . . . . . . . . . . . . 795
Sylvia Erhardt and
Barbara G. Mellone and
Craig M. Betts and
Weiguo Zhang and
Gary H. Karpen and
Aaron F. Straight Genome-wide analysis reveals a cell
cycle-dependent mechanism controlling
centromere propagation . . . . . . . . . 805
Jacqueline Whyte and
Jason R. Bader and
Sinji B. F. Tauhata and
Maurice Raycroft and
Jessica Hornick and
K. Kevin Pfister and
William S. Lane and
Gordon K. Chan and
Edward H. Hinchcliffe and
Patricia S. Vaughan and
Kevin T. Vaughan Phosphorylation regulates targeting of
cytoplasmic dynein to kinetochores
during mitosis . . . . . . . . . . . . . 819
Hui Zhu and
Judith A. Coppinger and
Chang-Young Jang and
John R. Yates and
Guowei Fang FAM29A promotes microtubule
amplification via recruitment of the
NEDD1-$ \gamma $-tubulin complex to the
mitotic spindle . . . . . . . . . . . . 835
Damian G. Wheeler and
Curtis F. Barrett and
Rachel D. Groth and
Parsa Safa and
Richard W. Tsien CaMKII locally encodes L-type channel
activity to signal to nuclear CREB in
excitation--transcription coupling . . . 849
Christian Frantz and
Gabriela Barreiro and
Laura Dominguez and
Xiaoming Chen and
Robert Eddy and
John Condeelis and
Mark J. S. Kelly and
Matthew P. Jacobson and
Diane L. Barber Cofilin is a pH sensor for actin free
barbed end formation: role of
phosphoinositide binding . . . . . . . . 865
Mingyu Gu and
Kim Schuske and
Shigeki Watanabe and
Qiang Liu and
Paul Baum and
Gian Garriga and
Erik M. Jorgensen $ \mu $2 adaptin facilitates but is not
essential for synaptic vesicle recycling
in \bionameCaenorhabditis elegans . . . 881
Seung-Hye Lee and
I.-Feng Peng and
Yu Gie Ng and
Masahiro Yanagisawa and
Shernaz X. Bamji and
Lisa P. Elia and
Janne Balsamo and
Jack Lilien and
Panos Z. Anastasiadis and
Erik M. Ullian and
Louis F. Reichardt Synapses are regulated by the
cytoplasmic tyrosine kinase Fer in a
pathway mediated by p120catenin, Fer,
SHP-2, and $ \beta $-catenin . . . . . . 893
Jerome Devaux and
Alexander Gow Tight junctions potentiate the
insulative properties of small CNS
myelinated axons . . . . . . . . . . . . 909
Khanh Huy Bui and
Hitoshi Sakakibara and
Tandis Movassagh and
Kazuhiro Oiwa and
Takashi Ishikawa Molecular architecture of inner dynein
arms in situ in Chlamydomonas
reinhardtii flagella . . . . . . . . . . 923
Alexei Poliakov and
Maria L. Cotrina and
Andrea Pasini and
David G. Wilkinson Regulation of EphB2 activation and cell
repulsion by feedback control of the
MAPK pathway . . . . . . . . . . . . . . 933
Paul W. Kriebel and
Valarie A. Barr and
Erin C. Rericha and
Guofeng Zhang and
Carole A. Parent Collective cell migration requires
vesicular trafficking for
chemoattractant delivery at the trailing
edge . . . . . . . . . . . . . . . . . . 949
Ruth Williams Multiple axons and actions with PSD-95 ??
Ruth Williams Junction protein goes on the road . . . ??
Ruth Williams CK2: channel controller . . . . . . . . ??
Ruth Williams The actin flow paradox . . . . . . . . . ??
Ben Short FHL1 adds some muscle . . . . . . . . . ??
Ruth Williams Andrea Ladd: Getting to the heart of
alternative splicing control . . . . . . 966
Emma Hill Announcing the JCB DataViewer, a
browser-based application for viewing
original image files . . . . . . . . . . 969
Mara C. Duncan and
Mark Peifer Regulating polarity by directing
traffic: Cdc42 prevents adherens
junctions from Crumblin' aPart . . . . . 971
Matthew N. Rasband Na$^+$ channels get anchored \ldots with
a little help . . . . . . . . . . . . . 975
Yinyi Huang and
Hongyan Yan and
Mohan K. Balasubramanian Assembly of normal actomyosin rings in
the absence of Mid1p and cortical nodes
in fission yeast . . . . . . . . . . . . 979
Wen-Hui Lien and
Vladimir I. Gelfand and
Valeri Vasioukhin $ \alpha $--E-catenin binds to dynamitin
and regulates dynactin-mediated
intracellular traffic . . . . . . . . . 989
Margaret L. Gardel and
Benedikt Sabass and
Lin Ji and
Gaudenz Danuser and
Ulrich S. Schwarz and
Clare M. Waterman Traction stress in focal adhesions
correlates biphasically with actin
retrograde flow speed . . . . . . . . . 999
Simone Reber and
Sabine Over and
Iva Kronja and
Oliver J. Gruss CaM kinase II initiates meiotic spindle
depolymerization independently of APC/C
activation . . . . . . . . . . . . . . . 1007
Nenggang Zhang and
Sergey G. Kuznetsov and
Shyam K. Sharan and
Kaiyi Li and
Pulivarthi H. Rao and
Debananda Pati A handcuff model for the cohesin complex 1019
Belinda S. Cowling and
Meagan J. McGrath and
Mai-Anh Nguyen and
Denny L. Cottle and
Anthony J. Kee and
Susan Brown and
Joachim Schessl and
Yaqun Zou and
Josephine Joya and
Carsten G. Bönnemann and
Edna C. Hardeman and
Christina A. Mitchell Identification of FHL1 as a regulator of
skeletal muscle mass: implications for
human myopathy . . . . . . . . . . . . . 1033
Sergio Casas-Tinto and
Melisa Gomez-Velazquez and
Begoña Granadino and
Pedro Fernandez-Funez FoxK mediates TGF-$ \beta $ signalling
during midgut differentiation in flies 1049
Dan Baird and
Chris Stefan and
Anjon Audhya and
Sabine Weys and
Scott D. Emr Assembly of the PtdIns $4$-kinase Stt4
complex at the plasma membrane requires
Ypp1 and Efr3 . . . . . . . . . . . . . 1061
Guido Grossmann and
Jan Malinsky and
Wiebke Stahlschmidt and
Martin Loibl and
Ina Weig-Meckl and
Wolf B. Frommer and
Miroslava Opekarová and
Widmar Tanner Plasma membrane microdomains regulate
turnover of transport proteins in yeast 1075
Hui-Ju Yang and
Hideki Nakanishi and
Song Liu and
James A. McNew and
Aaron M. Neiman Binding interactions control SNARE
specificity in vivo . . . . . . . . . . 1089
Aline Bréchet and
Marie-Pierre Fache and
Anna Brachet and
Géraldine Ferracci and
Agnés Baude and
Marie Irondelle and
Sandrine Pereira and
Christophe Leterrier and
Bénédicte Dargent Protein kinase CK2 contributes to the
organization of sodium channels in
axonal membranes by regulating their
interactions with ankyrin G . . . . . . 1101
Irina Nikonenko and
Bernadett Boda and
Sylvain Steen and
Graham Knott and
Egbert Welker and
Dominique Muller PSD-95 promotes synaptogenesis and
multiinnervated spine formation through
nitric oxide signaling . . . . . . . . . 1115
Kathryn P. Harris and
Ulrich Tepass Cdc42 and Par proteins stabilize dynamic
adherens junctions in the
\bionameDrosophila neuroectoderm through
regulation of apical endocytosis . . . . 1129
Weiyi Feng and
N. Patrick McCabe and
Ganapati H. Mahabeleshwar and
Payaningal R. Somanath and
David R. Phillips and
Tatiana V. Byzova The angiogenic response is dictated by $
\beta_3 $ integrin on bone
marrow--derived cells . . . . . . . . . 1145
Anny-Claude Luissint and
Pierre G. Lutz and
David A. Calderwood and
Pierre-Olivier Couraud and
Sandrine Bourdoulous JAM-L-mediated leukocyte adhesion to
endothelial cells is regulated in cis by
$ \alpha $4$ \beta $1 integrin
activation . . . . . . . . . . . . . . . 1159
Jiefei Geng and
Misuzu Baba and
Usha Nair and
Daniel J. Klionsky Quantitative analysis of
autophagy-related protein stoichiometry
by fluorescence microscopy . . . . . . . 1175
Mitch Leslie Cardio(lipin) workout beefs up
mitochondrial imports . . . . . . . . . ??
Mitch Leslie DNA, just chill . . . . . . . . . . . . ??
Mitch Leslie Leptin's long-distance call to the
pancreas . . . . . . . . . . . . . . . . ??
Mitch Leslie Matrix fragments trigger fatal
excitement . . . . . . . . . . . . . . . ??
Mitch Leslie Slow down, enzymes at work . . . . . . . ??
Caitlin Sedwick Kai Simons: Membrane master . . . . . . 1180
Torsten Wittmann EBs clip CLIPs to growing microtubule
ends . . . . . . . . . . . . . . . . . . 1183
Mattias Belting and
Anders Wittrup Nanotubes, exosomes, and nucleic
acid--binding peptides provide novel
mechanisms of intercellular
communication in eukaryotic cells:
implications in health and disease . . . 1187
Owen J. Marshall and
Alan T. Marshall and
K. H. Andy Choo Three-dimensional localization of
CENP--A suggests a complex higher order
structure of centromeric chromatin . . . 1193
Kazuto Sugimura and
Shin-ichiro Takebayashi and
Hiroshi Taguchi and
Shunichi Takeda and
Katsuzumi Okumura PARP-1 ensures regulation of replication
fork progression by homologous
recombination on damaged DNA . . . . . . 1203
Stephan Kutik and
Michael Rissler and
Xue Li Guan and
Bernard Guiard and
Guanghou Shui and
Natalia Gebert and
Philip N. Heacock and
Peter Rehling and
William Dowhan and
Markus R. Wenk and
Nikolaus Pfanner and
Nils Wiedemann The translocator maintenance protein
Tam41 is required for mitochondrial
cardiolipin biosynthesis . . . . . . . . 1213
Peter Bieling and
Stefanie Kandels-Lewis and
Ivo A. Telley and
Juliette van Dijk and
Carsten Janke and
Thomas Surrey CLIP-170 tracks growing microtubule ends
by dynamically recognizing composite
EB1/tubulin-binding sites . . . . . . . 1223
Eiichi Hinoi and
Nan Gao and
Dae Young Jung and
Vijay Yadav and
Tatsuya Yoshizawa and
Martin G. Myers and
Streamson C. Chua and
Jason K. Kim and
Klaus H. Kaestner and
Gerard Karsenty The sympathetic tone mediates leptin's
inhibition of insulin secretion by
modulating osteocalcin bioactivity . . . 1235
Motoshi Nagao and
Kenneth Campbell and
Kevin Burns and
Chia-Yi Kuan and
Andreas Trumpp and
Masato Nakafuku Coordinated control of self-renewal and
differentiation of neural stem cells by
Myc and the p19$^{\rm ARF}$-p53 pathway 1243
Elaine Sanij and
Gretchen Poortinga and
Kerith Sharkey and
Sandy Hung and
Timothy P. Holloway and
Jaclyn Quin and
Elysia Robb and
Lee H. Wong and
Walter G. Thomas and
Victor Stefanovsky and
Tom Moss and
Lawrence Rothblum and
Katherine M. Hannan and
Grant A. McArthur and
Richard B. Pearson and
Ross D. Hannan UBF levels determine the number of
active ribosomal RNA genes in mammals 1259
Takashi Matsuzaki and
Yukio Fujiki The peroxisomal membrane protein import
receptor Pex3p is directly transported
to peroxisomes by a novel Pex19p- and
Pex16p-dependent pathway . . . . . . . . 1275
Elodie Lewkowicz and
Floriane Herit and
Christophe Le Clainche and
Pierre Bourdoncle and
Franck Perez and
Florence Niedergang The microtubule-binding protein CLIP-170
coordinates mDia1 and actin
reorganization during CR3-mediated
phagocytosis . . . . . . . . . . . . . . 1287
Zu-Lin Chen and
Huaxu Yu and
Wei-Ming Yu and
Robert Pawlak and
Sidney Strickland Proteolytic fragments of laminin promote
excitotoxic neurodegeneration by
up-regulation of the KA1 subunit of the
kainate receptor . . . . . . . . . . . . 1299
Mitch Leslie Uniting to save cancer cells . . . . . . 1315
Mike Rossner A false sense of security . . . . . . . 1317
Caitlin Sedwick Lamin A/C deficiency is unnerving . . . ??
Caitlin Sedwick It takes two to party with chromatin . . ??
Caitlin Sedwick Htm1p: getting a ``sugar-handle'' on
misfolded proteins . . . . . . . . . . . ??
Caitlin Sedwick Lamin B locks up Oct-1 . . . . . . . . . ??
Caitlin Sedwick CERT loss puts the brakes on growth . . ??
Liz Savage Vivek Malhotra: Gaga for the Golgi . . . 4
Ira Mellman By the scientists, for the scientists 7
Tom Misteli The changing world of modern cell
biology . . . . . . . . . . . . . . . . 11
Helene Faustrup and
Simon Bekker-Jensen and
Jiri Bartek and
Jiri Lukas and
Niels Mailand USP7 counteracts SCF$^{\beta {\rm
TrCP}}$--- but not APC$^{\rm
Cdh1}$-mediated proteolysis of Claspin 13
Robert J. Scott and
Lucas V. Cairo and
David W. Van de Vosse and
Richard W. Wozniak The nuclear export factor Xpo1p targets
Mad1p to kinetochores in yeast . . . . . 21
Alexandre Méjat and
Valérie Decostre and
Juan Li and
Laure Renou and
Akanchha Kesari and
Daniel Hanta\"\i and
Colin L. Stewart and
Xiao Xiao and
Eric Hoffman and
Gis\`ele Bonne and
Tom Misteli Lamin A/C-mediated neuromuscular
junction defects in Emery--Dreifuss
muscular dystrophy . . . . . . . . . . . 31
Ashraf N. Malhas and
Chiu Fan Lee and
David J. Vaux Lamin B1 controls oxidative stress
responses via Oct-1 . . . . . . . . . . 45
Ren Xu and
Celeste M. Nelson and
John L. Muschler and
Mandana Veiseh and
Barbara K. Vonderhaar and
Mina J. Bissell Sustained activation of STAT5 is
essential for chromatin remodeling and
maintenance of mammary-specific function 57
Xin Zhang and
Irina Neganova and
Stefan Przyborski and
Chunbo Yang and
Michael Cooke and
Stuart P. Atkinson and
George Anyfantis and
Stefan Fenyk and
W. Nicol Keith and
Stacey F. Hoare and
Owen Hughes and
Tom Strachan and
Miodrag Stojkovic and
Philip W. Hinds and
Lyle Armstrong and
Majlinda Lako A role for NANOG in G1 to S transition
in human embryonic stem cells through
direct binding of CDK6 and CDC25A . . . 67
Vinicio A. de Jesus Perez and
Tero-Pekka Alastalo and
Jenny C. Wu and
Jeffrey D. Axelrod and
John P. Cooke and
Manuel Amieva and
Marlene Rabinovitch Bone morphogenetic protein 2 induces
pulmonary angiogenesis via Wnt-$ \beta
$-catenin and Wnt--RhoA--Rac1 pathways 83
Dana S. Wall and
Alan J. Mears and
Brian McNeill and
Chantal Mazerolle and
Sherry Thurig and
Yaping Wang and
Ryoichiro Kageyama and
Valerie A. Wallace Progenitor cell proliferation in the
retina is dependent on Notch-independent
Sonic hedgehog/Hes1 activity . . . . . . 101
Rachel H. Roberts-Galbraith and
Jun-Song Chen and
Jianqiu Wang and
Kathleen L. Gould The SH3 domains of two PCH family
members cooperate in assembly of the
\bionameSchizosaccharomyces pombe
contractile ring . . . . . . . . . . . . 113
Yasushi Tamura and
Yoshihiro Harada and
Takuya Shiota and
Koji Yamano and
Kazuaki Watanabe and
Mihoko Yokota and
Hayashi Yamamoto and
Hiromi Sesaki and
Toshiya Endo Tim23--Tim50 pair coordinates functions
of translocators and motor proteins in
mitochondrial protein import . . . . . . 129
Xin Wang and
Raghavendra Pralhada Rao and
Teresa Kosakowska-Cholody and
M. Athar Masood and
Eileen Southon and
Helin Zhang and
Cyril Berthet and
Kunio Nagashim and
Timothy K. Veenstra and
Lino Tessarollo and
Usha Acharya and
Jairaj K. Acharya Mitochondrial degeneration and not
apoptosis is the primary cause of
embryonic lethality in ceramide transfer
protein mutant mice . . . . . . . . . . 143
Simone Clerc and
Christian Hirsch and
Daniela Maria Oggier and
Paola Deprez and
Claude Jakob and
Thomas Sommer and
Markus Aebi Htm1 protein generates the N-glycan
signal for glycoprotein degradation in
the endoplasmic reticulum . . . . . . . 159
Anita Johswich and
Benjamin Kraft and
Manfred Wuhrer and
Monika Berger and
André M. Deelder and
Cornelis H. Hokke and
Rita Gerardy-Schahn and
Hans Bakker Golgi targeting of \bionameDrosophila
melanogaster $ \beta $4GalNAcTB requires
a DHHC protein family--related protein
as a pilot . . . . . . . . . . . . . . . 173
Mitch Leslie Membrane proteins stick around . . . . . ??
Mitch Leslie Birth control for centrioles . . . . . . ??
Mitch Leslie Apoptotic cells let down their guard . . ??
Mitch Leslie Unfolding chromatin nets . . . . . . . . ??
Caitlin Sedwick Jodi Nunnari: Keeping an eye on
mitochondrial inheritance . . . . . . . 188
Aimee deCathelineau and
Ben Short and
Ruth Williams The American Society for Cell Biology,
48th Annual Meeting San Francisco, CA,
December 13--17, 2008 . . . . . . . . . 190
Sharon Dewitt and
Richard L. Darley and
Maurice B. Hallett Translocation or just location?
Pseudopodia affect fluorescent signals 197
Yanming Wang and
Ming Li and
Sonja Stadler and
Sarah Correll and
Pingxin Li and
Danchen Wang and
Ryo Hayama and
Lauriebeth Leonelli and
Hyunsil Han and
Sergei A. Grigoryev and
C. David Allis and
Scott A. Coonrod Histone hypercitrullination mediates
chromatin decondensation and neutrophil
extracellular trap formation . . . . . . 205
Elsa-Noah N'Diaye and
Catherine S. Branda and
Steven S. Branda and
Lisette Nevarez and
Marco Colonna and
Clifford Lowell and
Jessica A. Hamerman and
William E. Seaman TREM-2 (triggering receptor expressed on
myeloid cells 2) is a phagocytic
receptor for bacteria . . . . . . . . . 215
Gregory C. Rogers and
Nasser M. Rusan and
David M. Roberts and
Mark Peifer and
Stephen L. Rogers The SCF$^{\rm Slimb}$ ubiquitin ligase
regulates Plk4/Sak levels to block
centriole reduplication . . . . . . . . 225
Vikas Anathy and
Scott W. Aesif and
Amy S. Guala and
Marije Havermans and
Niki L. Reynaert and
Ye-Shih Ho and
Ralph C. Budd and
Yvonne M. W. Janssen-Heininger Redox amplification of apoptosis by
caspase-dependent cleavage of
glutaredoxin 1 and S-glutathionylation
of Fas . . . . . . . . . . . . . . . . . 241
Badal Chandra Roy and
Naoto Kakinuma and
Ryoiti Kiyama Kank attenuates actin remodeling by
preventing interaction between IRSp53
and Rac1 . . . . . . . . . . . . . . . . 253
Christopher J. Staiger and
Michael B. Sheahan and
Parul Khurana and
Xia Wang and
David W. McCurdy and
Laurent Blanchoin Actin filament dynamics are dominated by
rapid growth and severing activity in
the Arabidopsis cortical array . . . . . 269
Yuntao S. Mao and
Masaki Yamaga and
Xiaohui Zhu and
Yongjie Wei and
Hui-Qiao Sun and
Jing Wang and
Mia Yun and
Yanfeng Wang and
Gilbert Di Paolo and
Michael Bennett and
Ira Mellman and
Charles S. Abrams and
Pietro De Camilli and
Christopher Y. Lu and
Helen L. Yin Essential and unique roles of PIP5K-$
\gamma $ and -$ \alpha $ in Fc$ \gamma $
receptor-mediated phagocytosis . . . . . 281
Gerald R. V. Hammond and
Yirong Sim and
Leon Lagnado and
Robin F. Irvine Reversible binding and rapid diffusion
of proteins in complex with inositol
lipids serves to coordinate free
movement with spatial information . . . 297
Young Kim and
Matthias C. Kugler and
Ying Wei and
Kevin K. Kim and
Xiaopeng Li and
Alexis N. Brumwell and
Harold A. Chapman Integrin $ \alpha $3$ \beta $1-dependent
$ \beta $-catenin phosphorylation links
epithelial Smad signaling to cell
contacts . . . . . . . . . . . . . . . . 309
Masamichi Yamamoto and
Hideyuki Beppu and
Katsuyoshi Takaoka and
Chikara Meno and
En Li and
Kohei Miyazono and
Hiroshi Hamada Antagonism between Smad1 and Smad2
signaling determines the site of distal
visceral endoderm formation in the mouse
embryo . . . . . . . . . . . . . . . . . 323
Motoshi Nagao and
Kenneth Campbell and
Kevin Burns and
Chia-Yi Kuan and
Andreas Trumpp and
Masato Nakafuku Coordinated control of self-renewal and
differentiation of neural stem cells by
Myc and the p19$^{\rm ARF}$-p53 pathway 335
Ben Short mRNP transport starts in the nucleus . . ??
Ben Short Cell cycle keeps Fus2p in check before
yeast mate . . . . . . . . . . . . . . . ??
Ben Short Mitotic spindle ties the Golgi ribbon ??
Ben Short Fibroblasts invade at a snail's pace . . ??
Ben Short Christian Ungermann: Taking apart
vacuole fusion . . . . . . . . . . . . . 340
Ronald D. Vale and
Karen Dell The biological sciences in India . . . . 342
Bruce F. McEwen and
Yimin Dong Releasing the spindle assembly
checkpoint without tension . . . . . . . 355
Simonetta Ausoni and
Saverio Sartore From fish to amphibians to mammals: in
search of novel strategies to optimize
cardiac regeneration . . . . . . . . . . 357
Alberto Toso and
Jennifer R. Winter and
Ainslie J. Garrod and
Ana C. Amaro and
Patrick Meraldi and
Andrew D. McAinsh Kinetochore-generated pushing forces
separate centrosomes during bipolar
spindle assembly . . . . . . . . . . . . 365
Thomas J. Maresca and
Edward D. Salmon Intrakinetochore stretch is associated
with changes in kinetochore
phosphorylation and spindle assembly
checkpoint activity . . . . . . . . . . 373
Kazuhiko S. K. Uchida and
Kentaro Takagaki and
Kazuki Kumada and
Youko Hirayama and
Tetsuo Noda and
Toru Hirota Kinetochore stretching inactivates the
spindle assembly checkpoint . . . . . . 383
Jen-Hsuan Wei and
Joachim Seemann The mitotic spindle mediates inheritance
of the Golgi ribbon structure . . . . . 391
R. Grant Rowe and
Xiao-Yan Li and
Yuexian Hu and
Thomas L. Saunders and
Ismo Virtanen and
Antonio Garcia de Herreros and
Karl-Friedrich Becker and
Signe Ingvarsen and
Lars H. Engelholm and
Guido T. Bommer and
Eric R. Fearon and
Stephen J. Weiss Mesenchymal cells reactivate Snail1
expression to drive three-dimensional
invasion programs . . . . . . . . . . . 399
Casey A. Ydenberg and
Mark D. Rose Antagonistic regulation of Fus2p nuclear
localization by pheromone signaling and
the cell cycle . . . . . . . . . . . . . 409
Alessandra di Penta and
Valentina Mercaldo and
Fulvio Florenzano and
Sebastian Munck and
M. Teresa Ciotti and
Francesca Zalfa and
Delio Mercanti and
Marco Molinari and
Claudia Bagni and
Tilmann Achsel Dendritic LSm1/CBP80-mRNPs mark the
early steps of transport commitment and
translational control . . . . . . . . . 423
Michael R. Dohn and
Meredith V. Brown and
Albert B. Reynolds An essential role for p120-catenin in
Src- and Rac1-mediated
anchorage-independent cell growth . . . 437
Jian-Jiang Hao and
Yin Liu and
Michael Kruhlak and
Karen E. Debell and
Barbara L. Rellahan and
Stephen Shaw Phospholipase C-mediated hydrolysis of
PIP2 releases ERM proteins from
lymphocyte membrane . . . . . . . . . . 451
Ruth Williams How Wld$^S$ neuroprotects . . . . . . . ??
Ruth Williams $1$D is like $3$D, but $2$D isn't . . . ??
Ruth Williams Portioning up PIE-1 . . . . . . . . . . ??
Ruth Williams Tankyrase: a new breed of telomere
security guard . . . . . . . . . . . . . ??
Ben Short Bmper sticker sends Bmp to lysosomes . . ??
Ben Short Valerie Horsley: Getting under the skin 466
Vishal M. Gohil and
Miriam L. Greenberg Mitochondrial membrane biogenesis:
phospholipids and proteins go hand in
hand . . . . . . . . . . . . . . . . . . 469
Brian R. Daniels and
Edward M. Perkins and
Terrence M. Dobrowsky and
Sean X. Sun and
Denis Wirtz Asymmetric enrichment of PIE-1 in the
\bionameCaenorhabditis elegans zygote
mediated by binary counterdiffusion . . 473
Andrew D. Doyle and
Francis W. Wang and
Kazue Matsumoto and
Kenneth M. Yamada One-dimensional topography underlies
three-dimensional fibrillar cell
migration . . . . . . . . . . . . . . . 481
Laura Conforti and
Anna Wilbrey and
Giacomo Morreale and
Lucie Janeckova and
Bogdan Beirowski and
Robert Adalbert and
Francesca Mazzola and
Michele Di Stefano and
Robert Hartley and
Elisabetta Babetto and
Trevor Smith and
Jonathan Gilley and
Richard A. Billington and
Armando A. Genazzani and
Richard R. Ribchester and
Giulio Magni and
Michael Coleman Wld$^S$ protein requires Nmnat activity
and a short N-terminal sequence to
protect axons in mice . . . . . . . . . 491
Michelle A. Avery and
Amy E. Sheehan and
Kimberly S. Kerr and
Jing Wang and
Marc R. Freeman Wld$^S$ requires Nmnat1 enzymatic
activity and N16--VCP interactions to
suppress Wallerian degeneration . . . . 501
Susan J. Hsiao and
Susan Smith Sister telomeres rendered dysfunctional
by persistent cohesion are fused by NHEJ 515
Dane A. Mohl and
Michael J. Huddleston and
Therese S. Collingwood and
Roland S. Annan and
Raymond J. Deshaies Dbf2--Mob1 drives relocalization of
protein phosphatase Cdc14 to the
cytoplasm during exit from mitosis . . . 527
Toshihide Mizoguchi and
Akinori Muto and
Nobuyuki Udagawa and
Atsushi Arai and
Teruhito Yamashita and
Akihiro Hosoya and
Tadashi Ninomiya and
Hiroaki Nakamura and
Yohei Yamamoto and
Saya Kinugawa and
Midori Nakamura and
Yuko Nakamichi and
Yasuhiro Kobayashi and
Sakae Nagasawa and
Kimimitsu Oda and
Hirofumi Tanaka and
Mitsuo Tagaya and
Josef M. Penninger and
Michio Ito and
Naoyuki Takahashi Identification of cell cycle--arrested
quiescent osteoclast precursors in vivo 541
Petra Björk and
ShaoBo Jin and
Jian Zhao and
Om Prakash Singh and
Jan-Olov Persson and
Ulf Hellman and
Lars Wieslander Specific combinations of SR proteins
associate with single pre-messenger RNAs
in vivo and contribute different
functions . . . . . . . . . . . . . . . 555
Suzanne Hoppins and
Jennifer Horner and
Cheng Song and
J. Michael McCaffery and
Jodi Nunnari Mitochondrial outer and inner membrane
fusion requires a modified carrier
protein . . . . . . . . . . . . . . . . 569
Christof Osman and
Mathias Haag and
Christoph Potting and
Jonathan Rodenfels and
Phat Vinh Dip and
Felix T. Wieland and
Britta Brügger and
Benedikt Westermann and
Thomas Langer The genetic interactome of prohibitins:
coordinated control of cardiolipin and
phosphatidylethanolamine by conserved
regulators in mitochondria . . . . . . . 583
Rusty Kelley and
Rongqin Ren and
Xinchun Pi and
Yaxu Wu and
Isabel Moreno and
Monte Willis and
Martin Moser and
Malcolm Ross and
Monika Podkowa and
Liliana Attisano and
Cam Patterson A concentration-dependent endocytic trap
and sink mechanism converts Bmper from
an activator to an inhibitor of Bmp
signaling . . . . . . . . . . . . . . . 597
Xinchun Pi and
Rongqin Ren and
Russell Kelley and
Chunlian Zhang and
Martin Moser and
Aparna B. Bohil and
Melinda DiVito and
Richard E. Cheney and
Cam Patterson Sequential roles for myosin--X in
BMP6-dependent filopodial extension,
migration, and activation of BMP
receptors . . . . . . . . . . . . . . . 611
Seung-Hwan Kim and
Antonia H. Holway and
Suzanne Wolff and
Andrew Dillin and
W. Matthew Michael SMK-1\slash PPH-4.1-mediated silencing
of the CHK-1 response to DNA damage in
early \bionameC. elegans embryos . . . . 613
Mitch Leslie Spindle's hidden collaborator exposed ??
Mitch Leslie Nuclear pore synthesis on a roll . . . . ??
Mitch Leslie Mitochondrial growth spurt . . . . . . . ??
Mitch Leslie Lipid rafts get connected . . . . . . . ??
Mitch Leslie Turn back, wayward axon . . . . . . . . ??
Liz Savage Bryan Krantz: From folding to unfolding
proteins . . . . . . . . . . . . . . . . 618
An-Chi Tien and
Akhila Rajan and
Hugo J. Bellen A Notch updated . . . . . . . . . . . . 621
Elinor R. Foster and
Jessica A. Downs Methylation of H3 K4 and K79 is not
strictly dependent on H2B K123
ubiquitylation . . . . . . . . . . . . . 631
Mark L. McCleland and
Jeffrey A. Farrell and
Patrick H. O'Farrell Influence of cyclin type and dose on
mitotic entry and progression in the
early \bionameDrosophila embryo . . . . 639
Mariana Lince-Faria and
Stefano Maffini and
Bernard Orr and
Yun Ding and
Cláudia Florindo and
Claudio E. Sunkel and
Álvaro Tavares and
Jòrgen Johansen and
Kristen M. Johansen and
Helder Maiato Spatiotemporal control of mitosis by the
conserved spindle matrix protein Megator 647
T. Renee Dawson and
Michelle D. Lazarus and
Martin W. Hetzer and
Susan R. Wente ER membrane--bending proteins are
necessary for de novo nuclear pore
formation . . . . . . . . . . . . . . . 659
Alain D. Silk and
Andrew J. Holland and
Don W. Cleveland Requirements for NuMA in maintenance and
establishment of mammalian spindle poles 677
Yulia Komarova and
Christian O. De Groot and
Ilya Grigoriev and
Susana Montenegro Gouveia and
E. Laura Munteanu and
Joseph M. Schober and
Srinivas Honnappa and
Rubén M. Buey and
Casper C. Hoogenraad and
Marileen Dogterom and
Gary G. Borisy and
Michel O. Steinmetz and
Anna Akhmanova Mammalian end binding proteins control
persistent microtubule growth . . . . . 691
Sarah B. Berman and
Ying-bei Chen and
Bing Qi and
J. Michael McCaffery and
Edmund B. Rucker and
Sandra Goebbels and
Klaus-Armin Nave and
Beth A. Arnold and
Elizabeth A. Jonas and
Fernando J. Pineda and
J. Marie Hardwick Bcl-x$_L$ increases mitochondrial
fission, fusion, and biomass in neurons 707
Ruth Rollason and
Viktor Korolchuk and
Clare Hamilton and
Mark Jepson and
George Banting A CD317/tetherin--RICH2 complex plays a
critical role in the organization of the
subapical actin cytoskeleton in
polarized epithelial cells . . . . . . . 721
Katsuhiko Hata and
Kozo Kaibuchi and
Shinobu Inagaki and
Toshihide Yamashita Unc5B associates with LARG to mediate
the action of repulsive guidance
molecule . . . . . . . . . . . . . . . . 737
Ferenc Deák and
Yi Xu and
Wen-Pin Chang and
Irina Dulubova and
Mikhail Khvotchev and
Xinran Liu and
Thomas C. Südhof and
Josep Rizo Munc18-1 binding to the neuronal SNARE
complex controls synaptic vesicle
priming . . . . . . . . . . . . . . . . 751
Ben Short KRas takes a different route . . . . . . ??
Ben Short Lipid droplets lead a Spartin existence ??
Ben Short GSK3$ \beta $ loosens the CLASP on
microtubules . . . . . . . . . . . . . . ??
Ben Short Time (and PPAR$ \beta $ /$ \delta $)
heals all wounds . . . . . . . . . . . . 767
Caitlin Sedwick Marko Kaksonen: Tracking the inner
secrets of endocytosis . . . . . . . . . 768
Thoru Pederson and
Robert Y. L. Tsai In search of nonribosomal nucleolar
protein function and regulation . . . . 771
Ana M. Meireles and
Katherine H. Fisher and
Nathalie Colombié and
James G. Wakefield and
Hiroyuki Ohkura Wac: a new Augmin subunit required for
chromosome alignment but not for
acentrosomal microtubule assembly in
female meiosis . . . . . . . . . . . . . 777
Yongjun Zhang and
Yizeng Tu and
Jianping Zhao and
Ka Chen and
Chuanyue Wu Reversion-induced LIM interaction with
Src reveals a novel Src inactivation
cycle . . . . . . . . . . . . . . . . . 785
Shan Yan and
W. Matthew Michael TopBP1 and DNA polymerase-$ \alpha $
directly recruit the 9-1-1 complex to
stalled DNA replication forks . . . . . 793
Xiaolin Liu and
Sizhou Huang and
Jun Ma and
Chun Li and
Yaoguang Zhang and
Lingfei Luo NF-$ \kappa $B and Snail1a coordinate
the cell cycle with gastrulation . . . . 805
Han Chung Chong and
Ming Jie Tan and
Virginie Philippe and
Siew Hwey Tan and
Chek Kun Tan and
Chee Wai Ku and
Yan Yih Goh and
Walter Wahli and
Liliane Michalik and
Nguan Soon Tan Regulation of epithelial--mesenchymal
IL-1 signaling by PPAR$ \beta $ /$
\delta $ is essential for skin
homeostasis and wound healing . . . . . 817
Marius Boulos Faza and
Stefan Kemmler and
Sonia Jimeno and
Cristina González-Aguilera and
Andrés Aguilera and
Ed Hurt and
Vikram Govind Panse Sem1 is a functional component of the
nuclear pore complex--associated
messenger RNA export machinery . . . . . 833
Rina Glozman and
Tsukasa Okiyoneda and
Cory M. Mulvihill and
James M. Rini and
Herve Barriere and
Gergely L. Lukacs N-glycans are direct determinants of
CFTR folding and stability in secretory
and endocytic membrane traffic . . . . . 847
Albert Lu and
Francesc Tebar and
Blanca Alvarez-Moya and
Cristina López-Alcalá and
Maria Calvo and
Carlos Enrich and
Neus Agell and
Takeshi Nakamura and
Michiyuki Matsuda and
Oriol Bachs A clathrin-dependent pathway leads to
KRas signaling on late endosomes en
route to lysosomes . . . . . . . . . . . 863
Scott W. Eastman and
Mina Yassaee and
Paul D. Bieniasz A role for ubiquitin ligases and
Spartin/SPG20 in lipid droplet turnover 881
Praveen Kumar and
Karen S. Lyle and
Sarah Gierke and
Alexandre Matov and
Gaudenz Danuser and
Torsten Wittmann GSK3$ \beta $ phosphorylation modulates
CLASP--microtubule association and
lamella microtubule attachment . . . . . 895
Fang Lin and
Songhai Chen and
Diane S. Sepich and
Jennifer Ray Panizzi and
Sherry G. Clendenon and
James A. Marrs and
Heidi E. Hamm and
Lilianna Solnica-Krezel G$ \alpha_{12 \slash 13} $ regulate
epiboly by inhibiting E-cadherin
activity and modulating the actin
cytoskeleton . . . . . . . . . . . . . . 909
Daniele Catalucci and
Deng-Hong Zhang and
Jaime DeSantiago and
Franck Aimond and
Guillaume Barbara and
Jean Chemin and
Désiré Bonci and
Eckard Picht and
Francesca Rusconi and
Nancy D. Dalton and
Kirk L. Peterson and
Sylvain Richard and
Donald M. Bers and
Joan Heller Brown and
Gianluigi Condorelli Akt regulates L-type Ca$^{2+}$ channel
activity by modulating Ca$_v$ $ \alpha
$1 protein stability . . . . . . . . . . 923
Ruth Williams Brain building . . . . . . . . . . . . . ??
Ruth Williams Speedy versus sluggish cells . . . . . . ??
Ruth Williams What do kidneys and embryonic fish skin
have in common? . . . . . . . . . . . . ??
Ruth Williams Blood, stress, and tiRNAs . . . . . . . 3
Caitlin Sedwick Suzanne Pfeffer: Sorting through
membrane trafficking . . . . . . . . . . 4
Farideh Sabeh and
Ryoko Shimizu-Hirota and
Stephen J. Weiss Protease-dependent versus -independent
cancer cell invasion programs:
three-dimensional amoeboid movement
revisited . . . . . . . . . . . . . . . 11
James G. McNally Transcription, chromatin condensation,
and gene migration . . . . . . . . . . . 7
Christoffel Dinant and
Martijn S. Luijsterburg and
Thomas Höfer and
Gesa von Bornstaedt and
Wim Vermeulen and
Adriaan B. Houtsmuller and
Roel van Driel Assembly of multiprotein complexes that
control genome function . . . . . . . . 21
Cristina Gontan and
Thomas Güttler and
Erik Engelen and
Jeroen Demmers and
Maarten Fornerod and
Frank G. Grosveld and
Dick Tibboel and
Dirk Görlich and
Raymond A. Poot and
Robbert J. Rottier Exportin 4 mediates a novel nuclear
import pathway for Sox family
transcription factors . . . . . . . . . 27
Satoshi Yamasaki and
Pavel Ivanov and
Guo-fu Hu and
Paul Anderson Angiogenin cleaves tRNA and promotes
stress-induced translational repression 35
Debrah M. Thompson and
Roy Parker The RNase Rny1p cleaves tRNAs and
promotes cell death during oxidative
stress in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 43
Anke M. Mulder and
Alex Glavis-Bloom and
Carolyn A. Moores and
Michael Wagenbach and
Bridget Carragher and
Linda Wordeman and
Ronald A. Milligan A new model for binding of kinesin 13 to
curved microtubule protofilaments . . . 51
Blue B. Lake and
Sergei Y. Sokol Strabismus regulates asymmetric cell
divisions and cell fate determination in
the mouse brain . . . . . . . . . . . . 59
Guizhong Liu and
Sapna Vijayakumar and
Luca Grumolato and
Randy Arroyave and
HuiFang Qiao and
Gal Akiri and
Stuart A. Aaronson Canonical Wnts function as potent
regulators of osteogenesis by human
mesenchymal stem cells . . . . . . . . . 67
Guangshuo Ou and
Ronald D. Vale Molecular signatures of cell migration
in \bionameC. elegans Q neuroblasts . . 77
Yan Hu and
Igor Kireev and
Matt Plutz and
Nazanin Ashourian and
Andrew S. Belmont Large-scale chromatin structure of
inducible genes: transcription on a
condensed, linear template . . . . . . . 87
Juliette Azimzadeh and
Polla Hergert and
Annie Delouvée and
Ursula Euteneuer and
Etienne Formstecher and
Alexey Khodjakov and
Michel Bornens hPOC5 is a centrin-binding protein
required for assembly of full-length
centrioles . . . . . . . . . . . . . . . 101
Alex S. Flynt and
Elizabeth J. Thatcher and
Kristopher Burkewitz and
Nan Li and
Yinzi Liu and
James G. Patton miR-8 microRNAs regulate the response to
osmotic stress in zebrafish embryos . . 115
Padinjat Raghu and
Elise Coessens and
Maria Manifava and
Plamen Georgiev and
Trevor Pettitt and
Eleanor Wood and
Isaac Garcia-Murillas and
Hanneke Okkenhaug and
Deepti Trivedi and
Qifeng Zhang and
Azam Razzaq and
Ola Zaid and
Michael Wakelam and
Cahir J. O'Kane and
Nicholas Ktistakis Rhabdomere biogenesis in
\bionameDrosophila photoreceptors is
acutely sensitive to phosphatidic acid
levels . . . . . . . . . . . . . . . . . 129
Jorge A. Pereira and
Yves Benninger and
Reto Baumann and
Ana Filipa Gonçalves and
Murat Özçelik and
Tina Thurnherr and
Nicolas Tricaud and
Dies Meijer and
Reinhard Fässler and
Ueli Suter and
João B. Relvas Integrin-linked kinase is required for
radial sorting of axons and Schwann cell
remyelination in the peripheral nervous
system . . . . . . . . . . . . . . . . . 147
Linda Schneider and
Christian-Martin Stock and
Peter Dieterich and
Bo Hammer Jensen and
Lotte Bang Pedersen and
Peter Satir and
Albrecht Schwab and
Sòren Tvorup Christensen and
Stine Falsig Pedersen The Na$^+$ /H$^+$ exchanger NHE1 is
required for directional migration
stimulated via PDGFR-$ \alpha $ in the
primary cilium . . . . . . . . . . . . . 163
Mitch Leslie SIRT1 takes down tumors . . . . . . . . ??
Mitch Leslie Autophagosomes meet before they eat . . ??
Mitch Leslie When cancer cells can't let go . . . . . ??
Mitch Leslie A plasmid goes motoring . . . . . . . . 179
Caitlin Sedwick Peter Friedl: Painting a picture of
cancer immunology . . . . . . . . . . . 180
Emma Hill and
Aimee deCathelineau and
Tom Misteli New science --- new ways to communicate
it . . . . . . . . . . . . . . . . . . . 183
James H. Hurley and
Xuefeng Ren The circuitry of cargo flux in the ESCRT
pathway . . . . . . . . . . . . . . . . 185
Anthony Letai Puma strikes Bax . . . . . . . . . . . . 189
Arne Lindqvist and
Verónica Rodríguez-Bravo and
René H. Medema The decision to enter mitosis: feedback
and redundancy in the mitotic entry
network . . . . . . . . . . . . . . . . 193
Jian Yuan and
Katherine Minter-Dykhouse and
Zhenkun Lou A c--Myc--SIRT1 feedback loop regulates
cell growth and transformation . . . . . 203
S. Brookhart Shields and
Andrea J. Oestreich and
Stanley Winistorfer and
Doris Nguyen and
Johanna A. Payne and
David J. Katzmann and
Robert Piper ESCRT ubiquitin-binding domains function
cooperatively during MVB cargo sorting 213
Vera A. Voronina and
Ken-Ichi Takemaru and
Piper Treuting and
Damon Love and
Barbara R. Grubb and
Adeline M. Hajjar and
Allison Adams and
Feng-Qian Li and
Randall T. Moon Inactivation of Chibby affects function
of motile airway cilia . . . . . . . . . 225
Maria Paola Paronetto and
Valeria Messina and
Enrica Bianchi and
Marco Barchi and
Gillian Vogel and
Costanzo Moretti and
Fioretta Palombi and
Mario Stefanini and
Raffaele Geremia and
Stéphane Richard and
Claudio Sette Sam68 regulates translation of target
mRNAs in male germ cells, necessary for
mouse spermatogenesis . . . . . . . . . 235
Hong Cui and
Santanu K. Ghosh and
Makkuni Jayaram The selfish yeast plasmid uses the
nuclear motor Kip1p but not Cin8p for
its localization and equal segregation 251
Jessica A. Hurt and
Robert A. Obar and
Bo Zhai and
Natalie G. Farny and
Steven P. Gygi and
Pamela A. Silver A conserved CCCH-type zinc finger
protein regulates mRNA nuclear
adenylation and export . . . . . . . . . 265
Tristan Gallenne and
Fabien Gautier and
Lisa Oliver and
Eric Hervouet and
Belinda Noël and
John A. Hickman and
Olivier Geneste and
Pierre-François Cartron and
François M. Vallette and
Stephen Manon and
Philippe Juin Bax activation by the BH3-only protein
Puma promotes cell dependence on
antiapoptotic Bcl-2 family members . . . 279
Claudia Manzl and
Gerhard Krumschnabel and
Florian Bock and
Benedicte Sohm and
Verena Labi and
Florian Baumgartner and
Emmanuelle Logette and
Jürg Tschopp and
Andreas Villunger Caspase-2 activation in the absence of
PIDDosome formation . . . . . . . . . . 291
Minoo Razi and
Edmond Y. W. Chan and
Sharon A. Tooze Early endosomes and endosomal coatomer
are required for autophagy . . . . . . . 305
Pirta Hotulainen and
Olaya Llano and
Sergei Smirnov and
Kimmo Tanhuanpää and
Jan Faix and
Claudio Rivera and
Pekka Lappalainen Defining mechanisms of actin
polymerization and depolymerization
during dendritic spine morphogenesis . . 323
Anna Fejtova and
Daria Davydova and
Ferdinand Bischof and
Vesna Lazarevic and
Wilko D. Altrock and
Stefano Romorini and
Cornelia Schöne and
Werner Zuschratter and
Michael R. Kreutz and
Craig C. Garner and
Noam E. Ziv and
Eckart D. Gundelfinger Dynein light chain regulates axonal
trafficking and synaptic levels of
Bassoon . . . . . . . . . . . . . . . . 341
Keefe T. Chan and
Christa L. Cortesio and
Anna Huttenlocher FAK alters invadopodia and focal
adhesion composition and dynamics to
regulate breast cancer invasion . . . . 357
Ruth Williams Centromere stabilizer . . . . . . . . . ??
Ruth Williams Ubiquitin traffic signals . . . . . . . ??
Ruth Williams How T cells shape their signals . . . . ??
Ruth Williams Drainage developers . . . . . . . . . . 373
Ben Short Mina Bissell: Context is everything . . 374
Michael Rexach Piecing together nuclear pore complex
assembly during interphase . . . . . . . 377
Patrick Lajoie and
Jacky G. Goetz and
James W. Dennis and
Ivan R. Nabi Lattices, rafts, and scaffolds: domain
regulation of receptor signaling at the
plasma membrane . . . . . . . . . . . . 381
Dirk Flemming and
Phillip Sarges and
Philipp Stelter and
Andrea Hellwig and
Bettina Böttcher and
Ed Hurt Two structurally distinct domains of the
nucleoporin Nup170 cooperate to tether a
subset of nucleoporins to nuclear pores 387
Marinela Perpelescu and
Naohito Nozaki and
Chikashi Obuse and
Hua Yang and
Kinya Yoda Active establishment of centromeric
CENP--A chromatin by RSF complex . . . . 397
Phillip A. Dumesic and
Florence A. Scholl and
Deborah I. Barragan and
Paul A. Khavari Erk1/2 MAP kinases are required for
epidermal G2/M progression . . . . . . . 409
Jorrit M. Enserink and
Hans Hombauer and
Meng-Er Huang and
Richard D. Kolodner Cdc28\slash Cdk1 positively and
negatively affects genome stability in
S. cerevisiae . . . . . . . . . . . . . 423
Camilla Norrmén and
Konstantin I. Ivanov and
Jianpin Cheng and
Nadine Zangger and
Mauro Delorenzi and
Muriel Jaquet and
Naoyuki Miura and
Pauli Puolakkainen and
Valerie Horsley and
Junhao Hu and
Hellmut G. Augustin and
Seppo Ylä-Herttuala and
Kari Alitalo and
Tatiana V. Petrova FOXC2 controls formation and maturation
of lymphatic collecting vessels through
cooperation with NFATc1 . . . . . . . . 439
Tadashi Makio and
Leslie H. Stanton and
Cheng-Chao Lin and
David S. Goldfarb and
Karsten Weis and
Richard W. Wozniak The nucleoporins Nup170p and Nup157p are
essential for nuclear pore complex
assembly . . . . . . . . . . . . . . . . 459
Evgeny Onischenko and
Leslie H. Stanton and
Alexis S. Madrid and
Thomas Kieselbach and
Karsten Weis Role of the Ndc1 interaction network in
yeast nuclear pore complex assembly and
maintenance . . . . . . . . . . . . . . 475
Elsa Lauwers and
Christophe Jacob and
Bruno André K63-linked ubiquitin chains as a
specific signal for protein sorting into
the multivesicular body pathway . . . . 493
Stefanie Lapetina and
Christopher C. Mader and
Kazuya Machida and
Bruce J. Mayer and
Anthony J. Koleske Arg interacts with cortactin to promote
adhesion-dependent cell edge protrusion 503
Yoshihisa Kaizuka and
Adam D. Douglass and
Santosh Vardhana and
Michael L. Dustin and
Ronald D. Vale The coreceptor CD2 uses plasma membrane
microdomains to transduce signals in T
cells . . . . . . . . . . . . . . . . . 521
Matthew L. Schwartz and
Alexey J. Merz Capture and release of partially zipped
trans--SNARE complexes on intact
organelles . . . . . . . . . . . . . . . 535
Eiji Inoue and
Maki Deguchi-Tawarada and
Aki Togawa and
Chiyuki Matsui and
Kohei Arita and
Sayaka Katahira-Tayama and
Toshitaka Sato and
Emiko Yamauchi and
Yoshiya Oda and
Yoshimi Takai Synaptic activity prompts $ \gamma
$-secretase-mediated cleavage of EphA4
and dendritic spine formation . . . . . 551
Ben Short Apratoxin chaperones EGFR to its
destruction . . . . . . . . . . . . . . ??
Ben Short BDNF sends mixed signals . . . . . . . . ??
Ben Short Decorin has Met a new receptor . . . . . ??
Ben Short Lipid rafts inflate at the trans--Golgi 567
Ben Short David Sherwood: Invasive procedures . . 568
Mike Rossner A challenge to Goliath . . . . . . . . . 571
Alexander R. Ball and
Kyoko Yokomori Revisiting the role of heterochromatin
protein 1 in DNA repair . . . . . . . . 573
Martijn S. Luijsterburg and
Christoffel Dinant and
Hannes Lans and
Jan Stap and
Elzbieta Wiernasz and
Saskia Lagerwerf and
Daniël O. Warmerdam and
Michael Lindh and
Maartje C. Brink and
Jurek W. Dobrucki and
Jacob A. Aten and
Maria I. Fousteri and
Gert Jansen and
Nico P. Dantuma and
Wim Vermeulen and
Leon H. F. Mullenders and
Adriaan B. Houtsmuller and
Pernette J. Verschure and
Roel van Driel Heterochromatin protein 1 is recruited
to various types of DNA damage . . . . . 577
Sophie Badie and
Chunyan Liao and
Maria Thanasoula and
Paul Barber and
Mark A. Hill and
Madalena Tarsounas RAD51C facilitates checkpoint signaling
by promoting CHK2 phosphorylation . . . 587
Robin W. Klemm and
Christer S. Ejsing and
Michal A. Surma and
Hermann-Josef Kaiser and
Mathias J. Gerl and
Julio L. Sampaio and
Quentin de Robillard and
Charles Ferguson and
Tomasz J. Proszynski and
Andrej Shevchenko and
Kai Simons Segregation of sphingolipids and sterols
during formation of secretory vesicles
at the trans-Golgi network . . . . . . . 601
Akos Szakmary and
Mary Reedy and
Hongying Qi and
Haifan Lin The Yb protein defines a novel organelle
and regulates male germline stem cell
self-renewal in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 613
Shensi Shen and
Pengtao Zhang and
Martin A. Lovchik and
Ying Li and
Liuya Tang and
Zhimin Chen and
Rong Zeng and
Dawei Ma and
Junying Yuan and
Qiang Yu Cyclodepsipeptide toxin promotes the
degradation of Hsp90 client proteins
through chaperone-mediated autophagy . . 629
Anna V. Bulankina and
Anke Deggerich and
Dirk Wenzel and
Kudzai Mutenda and
Julia G. Wittmann and
Markus G. Rudolph and
Koert N. J. Burger and
Stefan Höning TIP47 functions in the biogenesis of
lipid droplets . . . . . . . . . . . . . 641
Mark Winderlich and
Linda Keller and
Giuseppe Cagna and
Andre Broermann and
Olena Kamenyeva and
Friedemann Kiefer and
Urban Deutsch and
Astrid F. Nottebaum and
Dietmar Vestweber VE-PTP controls blood vessel development
by balancing Tie-2 activity . . . . . . 657
Salit Tzaban and
Ramiro H. Massol and
Elizabeth Yen and
Wendy Hamman and
Scott R. Frank and
Lynne A. Lapierre and
Steen H. Hansen and
James R. Goldenring and
Richard S. Blumberg and
Wayne I. Lencer The recycling and transcytotic pathways
for IgG transport by FcRn are distinct
and display an inherent polarity . . . . 673
Julie Karr and
Vasia Vagin and
Kaiyun Chen and
Subhashree Ganesan and
Oxana Olenkina and
Vladimir Gvozdev and
David E. Featherstone Regulation of glutamate receptor subunit
availability by microRNAs . . . . . . . 685
Joana Câmara and
Zhen Wang and
Cristina Nunes-Fonseca and
Hana C. Friedman and
Matthew Grove and
Diane L. Sherman and
Noboru H. Komiyama and
Seth G. Grant and
Peter J. Brophy and
Alan Peterson and
Charles ffrench-Constant Integrin-mediated axoglial interactions
initiate myelination in the central
nervous system . . . . . . . . . . . . . 699
Carlos Merino and
Jay Penney and
Miranda González and
Kazuya Tsurudome and
Myriam Moujahidine and
Michael B. O'Connor and
Esther M. Verheyen and
Pejmun Haghighi Nemo kinase interacts with Mad to
coordinate synaptic growth at the
\bionameDrosophila neuromuscular
junction . . . . . . . . . . . . . . . . 713
Feng Yang and
Hyun-Soo Je and
Yuanyuan Ji and
Guhan Nagappan and
Barbara Hempstead and
Bai Lu Pro-BDNF-induced synaptic depression and
retraction at developing neuromuscular
synapses . . . . . . . . . . . . . . . . 727
Silvia Goldoni and
Ashley Humphries and
Alexander Nyström and
Sampurna Sattar and
Rick T. Owens and
David J. McQuillan and
Keith Ireton and
Renato V. Iozzo Decorin is a novel antagonistic ligand
of the Met receptor . . . . . . . . . . 743
Ruth Williams Pygo2 opens chromatin and cycles cells ??
Ruth Williams Heart saves muscle . . . . . . . . . . . ??
Ruth Williams Dynamics of staying put . . . . . . . . ??
Ruth Williams Following the fat trail to death . . . . 757
Ruth Williams Hyung Don Ryoo: a healthy career in
cellular death . . . . . . . . . . . . . 758
Valerie Horsley Epigenetics, Wnt signaling, and stem
cells: the Pygo2 connection . . . . . . 761
Arthur E. Johnson The structural and functional coupling
of two molecular machines, the ribosome
and the translocon . . . . . . . . . . . 765
Gülsen Çolako\uglu and
Anthony Brown Intermediate filaments exchange subunits
along their length and elongate by
end-to-end annealing . . . . . . . . . . 769
Isabelle Dupin and
Emeline Camand and
Sandrine Etienne-Manneville Classical cadherins control nucleus and
centrosome position and cell polarity 779
Melanie A. McGill and
R. F. Andrew McKinley and
Tony J. C. Harris Independent cadherin--catenin and
Bazooka clusters interact to assemble
adherens junctions . . . . . . . . . . . 787
Wei-Qin Jiang and
Ze-Huai Zhong and
Akira Nguyen and
Jeremy D. Henson and
Christian D. Toouli and
Antony W. Braithwaite and
Roger R. Reddel Induction of alternative lengthening of
telomeres-associated PML bodies by
p53/p21 requires HP1 proteins . . . . . 797
Bingnan Gu and
Peng Sun and
Yuanyang Yuan and
Ricardo C. Moraes and
Aihua Li and
Andy Teng and
Anshu Agrawal and
Catherine Rhéaume and
Virginia Bilanchone and
Jacqueline M. Veltmaat and
Ken-Ichi Takemaru and
Sarah Millar and
Eva Y.-H. P. Lee and
Michael T. Lewis and
Boan Li and
Xing Dai Pygo2 expands mammary progenitor cells
by facilitating histone H3 K4
methylation . . . . . . . . . . . . . . 811
Qubo Zhu and
Lingjun Meng and
Joseph K. Hsu and
Tao Lin and
Jun Teishima and
Robert Y. L. Tsai GNL3L stabilizes the TRF1 complex and
promotes mitotic transition . . . . . . 827
Christiane Klebig and
Dirk Korinth and
Patrick Meraldi Bub1 regulates chromosome segregation in
a kinetochore-independent manner . . . . 841
Ying Wai Chan and
Luca L. Fava and
Andreas Uldschmid and
Michael H. A. Schmitz and
Daniel W. Gerlich and
Erich A. Nigg and
Anna Santamaria Mitotic control of
kinetochore-associated dynein and
spindle orientation by human Spindly . . 859
Victor A. Tallada and
Kenji Tanaka and
Mitsuhiro Yanagida and
Iain M. Hagan The S. pombe mitotic regulator Cut12
promotes spindle pole body activation
and integration into the nuclear
envelope . . . . . . . . . . . . . . . . 875
Martin R. Pool A trans-membrane segment inside the
ribosome exit tunnel triggers RAMP4
recruitment to the Sec61p translocase 889
Kristen J. Nowak and
Gianina Ravenscroft and
Connie Jackaman and
Aleksandra Filipovska and
Stefan M. Davies and
Esther M. Lim and
Sarah E. Squire and
Allyson C. Potter and
Elizabeth Baker and
Sophie Clément and
Caroline A. Sewry and
Victoria Fabian and
Kelly Crawford and
James L. Lessard and
Lisa M. Griffiths and
John M. Papadimitriou and
Yun Shen and
Grant Morahan and
Anthony J. Bakker and
Kay E. Davies and
Nigel G. Laing Rescue of skeletal muscle $ \alpha
$-actin--null mice by cardiac (fetal) $
\alpha $-actin . . . . . . . . . . . . . 903
Tony Yeung and
Bryan Heit and
Jean-Francois Dubuisson and
Gregory D. Fairn and
Basil Chiu and
Robert Inman and
Andras Kapus and
Michele Swanson and
Sergio Grinstein Contribution of phosphatidylserine to
membrane surface charge and protein
targeting during phagosome maturation 917
Mitch Leslie The downside of microtubule stability ??
Mitch Leslie CD44's nuclear road trip . . . . . . . . ??
Mitch Leslie How a membrane gets the bends . . . . . ??
Mitch Leslie Muscle atrophy through thick but not
thin . . . . . . . . . . . . . . . . . . 931
Ben Short Lucas Pelkmans: Taking it from the top 932
Beth A. A. Weaver and
Don W. Cleveland The role of aneuploidy in promoting and
suppressing tumors . . . . . . . . . . . 935
Kenji Tanabe and
Kohji Takei Dynamic instability of microtubules
requires dynamin 2 and is impaired in a
Charcot--Marie--Tooth mutant . . . . . . 939
Jia-Lin Lee and
Mei-Jung Wang and
Jeou-Yuan Chen Acetylation and activation of STAT3
mediated by nuclear translocation of
CD44 . . . . . . . . . . . . . . . . . . 949
Takashi Ishiuchi and
Kazuyo Misaki and
Shigenobu Yonemura and
Masatoshi Takeichi and
Takuji Tanoue Mammalian Fat and Dachsous cadherins
regulate apical membrane organization in
the embryonic cerebral cortex . . . . . 959
Rebecca C. Burgess and
Michael Lisby and
Veronika Altmannova and
Lumir Krejci and
Patrick Sung and
Rodney Rothstein Localization of recombination proteins
and Srs2 reveals anti-recombinase
function in vivo . . . . . . . . . . . . 969
Min Li and
Xiao Fang and
Zhubo Wei and
J. Philippe York and
Pumin Zhang Loss of spindle assembly
checkpoint-mediated inhibition of Cdc20
promotes tumorigenesis in mice . . . . . 983
Ryuichi Nishihama and
Jennifer H. Schreiter and
Masayuki Onishi and
Elizabeth A. Vallen and
Julia Hanna and
Katarina Moravcevic and
Margaret F. Lippincott and
Haesun Han and
Mark A. Lemmon and
John R. Pringle and
Erfei Bi Role of Inn1 and its interactions with
Hof1 and Cyk3 in promoting cleavage
furrow and septum formation in S.
cerevisiae . . . . . . . . . . . . . . . 995
Ana M. Vacaru and
Fikadu G. Tafesse and
Philipp Ternes and
Vangelis Kondylis and
Martin Hermansson and
Jos F. H. M. Brouwers and
Pentti Somerharju and
Catherine Rabouille and
Joost C. M. Holthuis Sphingomyelin synthase-related protein
SMSr controls ceramide homeostasis in
the ER . . . . . . . . . . . . . . . . . 1013
Yasushi Tamura and
Toshiya Endo and
Miho Iijima and
Hiromi Sesaki Ups1p and Ups2p antagonistically
regulate cardiolipin metabolism in
mitochondria . . . . . . . . . . . . . . 1029
Regina Rabl and
Vincent Soubannier and
Roland Scholz and
Frank Vogel and
Nadine Mendl and
Andreja Vasiljev-Neumeyer and
Christian Körner and
Ravi Jagasia and
Thomas Keil and
Wolfgang Baumeister and
Marek Cyrklaff and
Walter Neupert and
Andreas S. Reichert Formation of cristae and crista
junctions in mitochondria depends on
antagonism between Fcj1 and Su e /g . . 1047
Yan Li and
Seung Lim and
David Hoffman and
Pontus Aspenstrom and
Howard J. Federoff and
David A. Rempe HUMMR, a hypoxia- and HIF-1$ \alpha
$-inducible protein, alters
mitochondrial distribution and transport 1065
Shenhav Cohen and
Jeffrey J. Brault and
Steven P. Gygi and
David J. Glass and
David M. Valenzuela and
Carlos Gartner and
Esther Latres and
Alfred L. Goldberg During muscle atrophy, thick, but not
thin, filament components are degraded
by MuRF1-dependent ubiquitylation . . . 1083
Helen E. Burston and
Lymarie Maldonado-Báez and
Michael Davey and
Benjamen Montpetit and
Cayetana Schluter and
Beverly Wendland and
Elizabeth Conibear Regulators of yeast endocytosis
identified by systematic quantitative
analysis . . . . . . . . . . . . . . . . 1097
Stephen J. Warner and
Gregory D. Longmore Distinct functions for Rho1 in
maintaining adherens junctions and
apical tension in remodeling epithelia 1111
Houman Khosravani and
Yunfeng Zhang and
Shigeki Tsutsui and
Shahid Hameed and
Christophe Altier and
Jawed Hamid and
Lina Chen and
Michelle Villemaire and
Zenobia Ali and
Frank R. Jirik and
Gerald W. Zamponi Prion protein attenuates excitotoxicity
by inhibiting NMDA receptors . . . . . . 1127
Ben Short Bringing stability to microtubules . . . ??
Ben Short Desmoglein directs differentiation . . . ??
Ben Short Fibronectin is a good catch for integrin ??
Ben Short Microvilli give gut vesicles the
brush-off . . . . . . . . . . . . . . . 1131
Ruth Williams Antonio Giraldez: At the tip of the
microRNA iceberg . . . . . . . . . . . . 1132
Jennifer C. Waters Accuracy and precision in quantitative
fluorescence microscopy . . . . . . . . 1135
Alexandra Tibelius and
Joachim Marhold and
Hanswalter Zentgraf and
Christoph E. Heilig and
Heidemarie Neitzel and
Bernard Ducommun and
Anita Rauch and
Anthony D. Ho and
Jiri Bartek and
Alwin Krämer Microcephalin and pericentrin regulate
mitotic entry via centrosome-associated
Chk1 . . . . . . . . . . . . . . . . . . 1149
Leticia Peris and
Michael Wagenbach and
Laurence Lafanech\`ere and
Jacques Brocard and
Ayana T. Moore and
Frank Kozielski and
Didier Job and
Linda Wordeman and
Annie Andrieux Motor-dependent microtubule disassembly
driven by tubulin tyrosination . . . . . 1159
Ivo Zemp and
Thomas Wild and
Marie-Françoise O'Donohue and
Franziska Wandrey and
Barbara Widmann and
Pierre-Emmanuel Gleizes and
Ulrike Kutay Distinct cytoplasmic maturation steps of
40S ribosomal subunit precursors require
hRio2 . . . . . . . . . . . . . . . . . 1167
Prajal H. Patel and
Mauro Costa-Mattioli and
Karen L. Schulze and
Hugo J. Bellen The \bionameDrosophila deoxyhypusine
hydroxylase homologue nero and its
target eIF5A are required for cell
growth and the regulation of autophagy 1181
Denis Saint-Marcoux and
Francis-André Wollman and
Catherine de Vitry Biogenesis of cytochrome b$_6$ in
photosynthetic membranes . . . . . . . . 1195
Nuno Rocha and
Coenraad Kuijl and
Rik van der Kant and
Lennert Janssen and
Diane Houben and
Hans Janssen and
Wilbert Zwart and
Jacques Neefjes Cholesterol sensor ORP1L contacts the ER
protein VAP to control
Rab7--RILP--p150$^{\rm Glued}$ and late
endosome positioning . . . . . . . . . . 1209
Florian Fröhlich and
Karen Moreira and
Pablo S. Aguilar and
Nina C. Hubner and
Matthias Mann and
Peter Walter and
Tobias C. Walther A genome-wide screen for genes affecting
eisosomes reveals Nce102 function in
sphingolipid signaling . . . . . . . . . 1227
Spiro Getsios and
Cory L. Simpson and
Shin-ichiro Kojima and
Robert Harmon and
Linda J. Sheu and
Rachel L. Dusek and
Mona Cornwell and
Kathleen J. Green Desmoglein $1$-dependent suppression of
EGFR signaling promotes epidermal
differentiation and morphogenesis . . . 1243
Michele Bastiani and
Libin Liu and
Michelle M. Hill and
Mark P. Jedrychowski and
Susan J. Nixon and
Harriet P. Lo and
Daniel Abankwa and
Robert Luetterforst and
Manuel Fernandez-Rojo and
Michael R. Breen and
Steven P. Gygi and
Jorgen Vinten and
Piers J. Walser and
Kathryn N. North and
John F. Hancock and
Paul F. Pilch and
Robert G. Parton MURC\slash Cavin-4 and cavin family
members form tissue-specific caveolar
complexes . . . . . . . . . . . . . . . 1259
Fang Kong and
Andrés J. García and
A. Paul Mould and
Martin J. Humphries and
Cheng Zhu Demonstration of catch bonds between an
integrin and its ligand . . . . . . . . 1275
Russell E. McConnell and
James N. Higginbotham and
David A. Shifrin and
David L. Tabb and
Robert J. Coffey and
Matthew J. Tyska The enterocyte microvillus is a
vesicle-generating organelle . . . . . . 1285
Mitch Leslie Building memories with actin . . . . . . ??
Mitch Leslie Brain-repairing cells follow trail of
GABA . . . . . . . . . . . . . . . . . . ??
Mitch Leslie Calcium channel roundup . . . . . . . . ??
Mitch Leslie For chromosomes, equality means
segregation . . . . . . . . . . . . . . 3
Ben Short Marian Walhout: Transcriptional mapmaker 4
Matthew B. Dalva Neuronal activity moves protein
palmitoylation into the synapse . . . . 7
Irina Matos and
António J. Pereira and
Mariana Lince-Faria and
Lisa A. Cameron and
Edward D. Salmon and
Helder Maiato Synchronizing chromosome segregation by
flux-dependent force equalization at
kinetochores . . . . . . . . . . . . . . 11
Shobbir Hussain and
Sandra Blanco Benavente and
Elisabete Nascimento and
Ilaria Dragoni and
Agata Kurowski and
Astrid Gillich and
Peter Humphreys and
Michaela Frye The nucleolar RNA methyltransferase Misu
(NSun2) is required for mitotic spindle
stability . . . . . . . . . . . . . . . 27
Debrup Sengupta and
Steven Truschel and
Collin Bachert and
Adam D. Linstedt Organelle tethering by a homotypic PDZ
interaction underlies formation of the
Golgi membrane network . . . . . . . . . 41
Jessica K. Sawyer and
Nathan J. Harris and
Kevin C. Slep and
Ulrike Gaul and
Mark Peifer The \bionameDrosophila afadin homologue
Canoe regulates linkage of the actin
cytoskeleton to adherens junctions
during apical constriction . . . . . . . 57
Arye Elfenbein and
John M. Rhodes and
Julia Meller and
Martin A. Schwartz and
Michiyuki Matsuda and
Michael Simons Suppression of RhoG activity is mediated
by a syndecan 4--synectin--RhoGDI1
complex and is reversed by PKC$ \alpha $
in a Rac1 activation pathway . . . . . . 75
Christopher S. Rex and
Lulu Y. Chen and
Anupam Sharma and
Jihua Liu and
Alex H. Babayan and
Christine M. Gall and
Gary Lynch Different Rho GTPase-dependent signaling
pathways initiate sequential steps in
the consolidation of long-term
potentiation . . . . . . . . . . . . . . 85
Anjali Teckchandani and
Natalie Toida and
Jake Goodchild and
Christine Henderson and
Julian Watts and
Bernd Wollscheid and
Jonathan A. Cooper Quantitative proteomics identifies a
Dab2/integrin module regulating cell
migration . . . . . . . . . . . . . . . 99
Xiao-ping Tong and
Xiang-yao Li and
Bing Zhou and
Wanhua Shen and
Zhi-jun Zhang and
Tian-le Xu and
Shumin Duan Ca$^{2+}$ signaling evoked by activation
of Na$^+$ channels and Na$^+$ /Ca$^{2+}$
exchangers is required for GABA-induced
NG2 cell migration . . . . . . . . . . . 113
Wernher Fouquet and
David Owald and
Carolin Wichmann and
Sara Mertel and
Harald Depner and
Marcus Dyba and
Stefan Hallermann and
Robert J. Kittel and
Stefan Eimer and
Stephan J. Sigrist Maturation of active zone assembly by
\bionameDrosophila Bruchpilot . . . . . 129
Jun Noritake and
Yuko Fukata and
Tsuyoshi Iwanaga and
Naoki Hosomi and
Ryouhei Tsutsumi and
Naoto Matsuda and
Hideki Tani and
Hiroko Iwanari and
Yasuhiro Mochizuki and
Tatsuhiko Kodama and
Yoshiharu Matsuura and
David S. Bredt and
Takao Hamakubo and
Masaki Fukata Mobile DHHC palmitoylating enzyme
mediates activity-sensitive synaptic
targeting of PSD-95 . . . . . . . . . . 147
Min Li and
Xiao Fang and
Zhubo Wei and
J. Philippe York and
Pumin Zhang Loss of spindle assembly
checkpoint-mediated inhibition of Cdc20
promotes tumorigenesis in mice . . . . . 161
Mitch Leslie Preventing the nuclear envelope from
getting on a roll . . . . . . . . . . . ??
Mitch Leslie Calcium's route to freedom . . . . . . . ??
Mitch Leslie Killing the $ \beta $-catenin messenger ??
Nicole LeBrasseur HIV uses autophagy for its own means . . 165
Ben Short Matt Gibson: The blueprints of tissue
architecture . . . . . . . . . . . . . . 166
Vytas A. Bankaitis The Cirque du Soleil of Golgi membrane
dynamics . . . . . . . . . . . . . . . . 169
Miho Amano and
Aussie Suzuki and
Tetsuya Hori and
Chelsea Backer and
Katsuya Okawa and
Iain M. Cheeseman and
Tatsuo Fukagawa The CENP--S complex is essential for the
stable assembly of outer kinetochore
structure . . . . . . . . . . . . . . . 173
Daniel J. Anderson and
Jesse D. Vargas and
Joshua P. Hsiao and
Martin W. Hetzer Recruitment of functionally distinct
membrane proteins to chromatin mediates
nuclear envelope formation in vivo . . . 183
Wilma A. Hofmann and
Alessandro Arduini and
Samantha M. Nicol and
Carlos J. Camacho and
James L. Lessard and
Frances V. Fuller-Pace and
Primal de Lanerolle SUMOylation of nuclear actin . . . . . . 193
Eugen Brailoiu and
Dev Churamani and
Xinjiang Cai and
Michael G. Schrlau and
G. Cristina Brailoiu and
Xin Gao and
Robert Hooper and
Michael J. Boulware and
Nae J. Dun and
Jonathan S. Marchant and
Sandip Patel Essential requirement for two-pore
channel 1 in NAADP-mediated calcium
signaling . . . . . . . . . . . . . . . 201
John A. Schmidt and
William J. Brown Lysophosphatidic acid acyltransferase 3
regulates Golgi complex structure and
function . . . . . . . . . . . . . . . . 211
Meghan T. Maher and
Annette S. Flozak and
Adam M. Stocker and
Anjen Chenn and
Cara J. Gottardi Activity of the $ \beta $-catenin
phosphodestruction complex at cell--cell
contacts is enhanced by cadherin-based
adhesion . . . . . . . . . . . . . . . . 219
Kang Zhou and
Melissa M. Rolls and
David H. Hall and
Christian J. Malone and
Wendy Hanna-Rose A ZYG-12--dynein interaction at the
nuclear envelope defines cytoskeletal
architecture in the \bionameC. elegans
gonad . . . . . . . . . . . . . . . . . 229
David Landeira and
Jean-Mathieu Bart and
Daria Van Tyne and
Miguel Navarro Cohesin regulates VSG monoallelic
expression in trypanosomes . . . . . . . 243
George B. Kyei and
Christina Dinkins and
Alexander S. Davis and
Esteban Roberts and
Sudha B. Singh and
Chunsheng Dong and
Li Wu and
Eiki Kominami and
Takashi Ueno and
Akitsugu Yamamoto and
Maurizio Federico and
Antonito Panganiban and
Isabelle Vergne and
Vojo Deretic Autophagy pathway intersects with HIV-1
biosynthesis and regulates viral yields
in macrophages . . . . . . . . . . . . . 255
Glen A. Farr and
Michael Hull and
Ira Mellman and
Michael J. Caplan Membrane proteins follow multiple
pathways to the basolateral cell surface
in polarized epithelial cells . . . . . 269
Ramila S. Patel-King and
Stephen M. King An outer arm dynein light chain acts in
a conformational switch for flagellar
motility . . . . . . . . . . . . . . . . 283
Jingxia Li and
Haobin Chen and
Moon-Shong Tang and
Xianglin Shi and
Shantu Amin and
Dhimant Desai and
Max Costa and
Chuanshu Huang PI-3K and Akt are mediators of AP-1
induction by 5-MCDE in mouse epidermal
Cl41 cells . . . . . . . . . . . . . . . 297
Mitch Leslie Both routes to cell death necessary . . ??
Mitch Leslie Dystrophin makes a new connection . . . ??
Mitch Leslie Chlamydomonas does the lopsided wave . . ??
Mitch Leslie From gene manager to traffic cop . . . . 301
Ruth Williams Marc Freeman: Fishing for the function
of fly glia . . . . . . . . . . . . . . 302
Ben Short Cell biologists expand their networks 305
John A. Latham and
Sharon Y. R. Dent The H2BK123Rgument . . . . . . . . . . . 313
Ronen Zaidel-Bar Evolution of complexity in the integrin
adhesome . . . . . . . . . . . . . . . . 317
Julie Hollien and
Jonathan H. Lin and
Han Li and
Nicole Stevens and
Peter Walter and
Jonathan S. Weissman Regulated Ire1-dependent decay of
messenger RNAs in mammalian cells . . . 323
Ai Khim Lim and
Liheng Tao and
Toshie Kai piRNAs mediate posttranscriptional
retroelement silencing and localization
to pi-bodies in the \bionameDrosophila
germline . . . . . . . . . . . . . . . . 333
Zhuojin Xu and
Qiang Gong and
Bin Xia and
Benjamin Groves and
Marc Zimmermann and
Chris Mugler and
Dezhi Mu and
Brian Matsumoto and
Matthew Seaman and
Dzwokai Ma A role of histone H3 lysine 4
methyltransferase components in
endosomal trafficking . . . . . . . . . 343
Delphine Mérino and
Maybelline Giam and
Peter D. Hughes and
Owen M. Siggs and
Klaus Heger and
Lorraine A. O'Reilly and
Jerry M. Adams and
Andreas Strasser and
Erinna F. Lee and
Walter D. Fairlie and
Philippe Bouillet The role of BH3-only protein Bim extends
beyond inhibiting Bcl-2-like prosurvival
proteins . . . . . . . . . . . . . . . . 355
Kurt W. Prins and
Jill L. Humston and
Amisha Mehta and
Victoria Tate and
Evelyn Ralston and
James M. Ervasti Dystrophin is a microtubule-associated
protein . . . . . . . . . . . . . . . . 363
Shima Nakanishi and
Jung Shin Lee and
Kathryn E. Gardner and
Jennifer M. Gardner and
Yoh-hei Takahashi and
Mahesh B. Chandrasekharan and
Zu-Wen Sun and
Mary Ann Osley and
Brian D. Strahl and
Sue L. Jaspersen and
Ali Shilatifard Histone H2BK123 monoubiquitination is
the critical determinant for H3K4 and
H3K79 trimethylation by COMPASS and Dot1 371
Tomasz Zimniak and
Katharina Stengl and
Karl Mechtler and
Stefan Westermann Phosphoregulation of the budding yeast
EB1 homologue Bim1p by Aurora/Ipl1p . . 379
Kimi Yamakoshi and
Akiko Takahashi and
Fumiko Hirota and
Rika Nakayama and
Naozumi Ishimaru and
Yoshiaki Kubo and
David J. Mann and
Masako Ohmura and
Atsushi Hirao and
Hideyuki Saya and
Seiji Arase and
Yoshio Hayashi and
Kazuki Nakao and
Mitsuru Matsumoto and
Naoko Ohtani and
Eiji Hara Real-time in vivo imaging of p16$^{\rm
Ink4a}$ reveals cross talk with p53 . . 393
Chang-Hun Lee and
Pierre A. Coulombe Self-organization of keratin
intermediate filaments into cross-linked
networks . . . . . . . . . . . . . . . . 409
Sabina E. Winograd-Katz and
Shalev Itzkovitz and
Zvi Kam and
Benjamin Geiger Multiparametric analysis of focal
adhesion formation by RNAi-mediated gene
knockdown . . . . . . . . . . . . . . . 423
Khanh Huy Bui and
Hitoshi Sakakibara and
Tandis Movassagh and
Kazuhiro Oiwa and
Takashi Ishikawa Asymmetry of inner dynein arms and
inter-doublet links in Chlamydomonas
flagella . . . . . . . . . . . . . . . . 437
Kalliopi Pilichou and
Carol Ann Remme and
Cristina Basso and
Maria E. Campian and
Stefania Rizzo and
Phil Barnett and
Brendon P. Scicluna and
Barbara Bauce and
Maurice J. B. van den Hoff and
Jacques M. T. de Bakker and
Hanno L. Tan and
Marialuisa Valente and
Andrea Nava and
Arthur A. M. Wilde and
Antoon F. M. Moorman and
Gaetano Thiene and
Connie R. Bezzina Myocyte necrosis underlies progressive
myocardial dystrophy in mouse dsg2
-related arrhythmogenic right
ventricular cardiomyopathy . . . . . . . ??
Ben Short Peroxisome inheritance at the right time
and place . . . . . . . . . . . . . . . ??
Ben Short Myosin drives bladder movements . . . . ??
Eun Choi Ubiquitin drives cilia shortening . . . ??
Ben Short Aurora B answers an XIST-ential question 449
Ben Short Alexander Meissner: Learning the
reprogramming code . . . . . . . . . . . 450
Emma Hill and
Ruth Williams Super-coil me: Sizing up centromeric
nucleosomes . . . . . . . . . . . . . . 453
Ben Nichols Endocytosis of lipid-anchored proteins:
excluding GEECs from the crowd . . . . . 457
David Razafsky and
Didier Hodzic Bringing KASH under the SUN: the many
faces of nucleo-cytoskeletal connections 461
Zhonghua Liu and
Yixian Zheng A requirement for epsin in mitotic
membrane and spindle organization . . . 473
Vito Mennella and
Dong-Yan Tan and
Daniel W. Buster and
Ana B. Asenjo and
Uttama Rath and
Ao Ma and
Hernando J. Sosa and
David J. Sharp Motor domain phosphorylation and
regulation of the \bionameDrosophila
kinesin 13, KLP10A . . . . . . . . . . . 481
Lisa L. Hall and
Meg Byron and
Gayle Pageau and
Jeanne B. Lawrence AURKB-mediated effects on chromatin
regulate binding versus release of XIST
RNA to the inactive chromosome . . . . . 491
Federica Madia and
Min Wei and
Valerie Yuan and
Jia Hu and
Cristina Gattazzo and
Phuong Pham and
Myron F. Goodman and
Valter D. Longo Oncogene homologue Sch9 promotes
age-dependent mutations by a superoxide
and Rev1/Pol$ \zeta $-dependent
mechanism . . . . . . . . . . . . . . . 509
Stéphane G. Rolland and
Yun Lu and
Charles N. David and
Barbara Conradt The BCL-2-like protein CED-9 of
\bionameC. elegans promotes
FZO-1/Mfn1,2- and EAT-3/Opa1-dependent
mitochondrial fusion . . . . . . . . . . 525
Andrei Fagarasanu and
Fred D. Mast and
Barbara Knoblach and
Yui Jin and
Matthew J. Brunner and
Michael R. Logan and
J. N. Mark Glover and
Gary A. Eitzen and
John D. Aitchison and
Lois S. Weisman and
Richard A. Rachubinski Myosin-driven peroxisome partitioning in
S. cerevisiae . . . . . . . . . . . . . 541
Goeh Jung and
Margaret A. Titus and
John A. Hammer The \bionameDictyostelium type V myosin
MyoJ is responsible for the cortical
association and motility of contractile
vacuole membranes . . . . . . . . . . . 555
Matthew Oser and
Hideki Yamaguchi and
Christopher C. Mader and
J. J. Bravo-Cordero and
Marianela Arias and
Xiaoming Chen and
Vera DesMarais and
Jacco van Rheenen and
Anthony J. Koleske and
John Condeelis Cortactin regulates cofilin and N--WASp
activities to control the stages of
invadopodium assembly and maturation . . 571
Jian-Ping Xiong and
Bhuvaneshwari Mahalingham and
Jose Luis Alonso and
Laura Ann Borrelli and
Xianliang Rui and
Saurabh Anand and
Bradley T. Hyman and
Thomas Rysiok and
Dirk Müller-Pompalla and
Simon L. Goodman and
M. Amin Arnaout Crystal structure of the complete
integrin $ \alpha $V$ \beta $3
ectodomain plus an $ \alpha $ /$ \beta $
transmembrane fragment . . . . . . . . . 589
Kaiyao Huang and
Dennis R. Diener and
Joel L. Rosenbaum The ubiquitin conjugation system is
involved in the disassembly of cilia and
flagella . . . . . . . . . . . . . . . . 601
Pinkesh Bhagatji and
Rania Leventis and
Jonathan Comeau and
Mohammad Refaei and
John R. Silvius Steric and not structure-specific
factors dictate the endocytic mechanism
of glycosylphosphatidylinositol-anchored
proteins . . . . . . . . . . . . . . . . 615
Kumiko Oishi and
Hideyuki Okano and
Hitoshi Sawa RMD-1, a novel microtubule-associated
protein, functions in chromosome
segregation in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 629
Mitch Leslie Cytomegalovirus sticks it to MHC . . . . ??
Mitch Leslie Putting the squeeze on apoptotic cells ??
Mitch Leslie Stopping sister synapses . . . . . . . . ??
Mitch Leslie Managing the breakup . . . . . . . . . . 633
Nicole LeBrasseur Louis Reichardt: the long climb to
science's summits . . . . . . . . . . . 634
Charles S. Bond and
Archa H. Fox Paraspeckles: nuclear bodies built on
long noncoding RNA . . . . . . . . . . . 637
Karin M. Gilljam and
Emadoldin Feyzi and
Per A. Aas and
Mirta M. L. Sousa and
Rebekka Müller and
Cathrine B. Vågbò and
Tara C. Catterall and
Nina B. Liabakk and
Geir Slupphaug and
Finn Drablòs and
Hans E. Krokan and
Marit Otterlei Identification of a novel, widespread,
and functionally important PCNA-binding
motif . . . . . . . . . . . . . . . . . 645
Kasper Fugger and
Martin Mistrik and
Jannie Rendtlew Danielsen and
Christoffel Dinant and
Jacob Falck and
Jiri Bartek and
Jiri Lukas and
Niels Mailand Human Fbh1 helicase contributes to
genome maintenance via pro- and
anti-recombinase activities . . . . . . 655
Sonia Stefanovic and
Nesrine Abboud and
Stéphanie Désilets and
David Nury and
Chad Cowan and
Michel Pucéat Interplay of Oct4 with Sox2 and Sox17: a
molecular switch from stem cell
pluripotency to specifying a cardiac
fate . . . . . . . . . . . . . . . . . . 665
Zhenye Yang and
Alison E. Kenny and
Daniela A. Brito and
Conly L. Rieder Cells satisfy the mitotic checkpoint in
Taxol, and do so faster in
concentrations that stabilize syntelic
attachments . . . . . . . . . . . . . . 675
Helen R. Stagg and
Mair Thomas and
Dick van den Boomen and
Emmanuel J. H. J. Wiertz and
Harry A. Drabkin and
Robert M. Gemmill and
Paul J. Lehner The TRC8 E3 ligase ubiquitinates MHC
class I molecules before dislocation
from the ER . . . . . . . . . . . . . . 685
Gloria Slattum and
Karen M. McGee and
Jody Rosenblatt P115 RhoGEF and microtubules decide the
direction apoptotic cells extrude from
an epithelium . . . . . . . . . . . . . 693
Tao Wang and
Uyen Lao and
Bruce A. Edgar TOR-mediated autophagy regulates cell
death in \bionameDrosophila
neurodegenerative disease . . . . . . . 703
Hui Jin and
Vincent Guacci and
Hong-Guo Yu Pds5 is required for homologue pairing
and inhibits synapsis of sister
chromatids during yeast meiosis . . . . 713
Ronald D. Vale and
James A. Spudich and
Eric R. Griffis Dynamics of myosin, microtubules, and
Kinesin-6 at the cortex during
cytokinesis in \bionameDrosophila S2
cells . . . . . . . . . . . . . . . . . 727
Juan Carlos García-Cortés and
Dannel McCollum Proper timing of cytokinesis is
regulated by \bionameSchizosaccharomyces
pombe Etd1 . . . . . . . . . . . . . . . 739
Chau H. Nguyen and
Hong Ming and
Peishen Zhao and
Lynne Hugendubler and
Robert Gros and
Scot R. Kimball and
Peter Chidiac Translational control by RGS2 . . . . . 755
Ben Short How ER stress gives cells the CHOP . . . ??
Ben Short The long and short of mitochondrial
fusion . . . . . . . . . . . . . . . . . ??
Ben Short Cell packing comes under the lens . . . ??
Ben Short Rab2 directs a stop-loss program . . . . 769
Ben Short Iain Cheeseman: a strong attachment to
kinetochores . . . . . . . . . . . . . . 770
Anne Simonsen and
Sharon A. Tooze Coordination of membrane events during
autophagy by multiple class III
PI3-kinase complexes . . . . . . . . . . 773
Gang Li and
Marco Mongillo and
King-Tung Chin and
Heather Harding and
David Ron and
Andrew R. Marks and
Ira Tabas Role of ERO1-$ \alpha $-mediated
stimulation of inositol
1,4,5-triphosphate receptor activity in
endoplasmic reticulum stress--induced
apoptosis . . . . . . . . . . . . . . . 783
Rachel M. DeVay and
Lenin Dominguez-Ramirez and
Laura L. Lackner and
Suzanne Hoppins and
Henning Stahlberg and
Jodi Nunnari Coassembly of Mgm1 isoforms requires
cardiolipin and mediates mitochondrial
inner membrane fusion . . . . . . . . . 793
Junko Wakabayashi and
Zhongyan Zhang and
Nobunao Wakabayashi and
Yasushi Tamura and
Masahiro Fukaya and
Thomas W. Kensler and
Miho Iijima and
Hiromi Sesaki The dynamin-related GTPase Drp1 is
required for embryonic and brain
development in mice . . . . . . . . . . 805
Avanti Gokhale and
Maureen Wirschell and
Winfield S. Sale Regulation of dynein-driven microtubule
sliding by the axonemal protein kinase
CK1 in Chlamydomonas flagella . . . . . 817
Peter R. Cook and
Davide Marenduzzo Entropic organization of interphase
chromosomes . . . . . . . . . . . . . . 825
Jurgen A. Marteijn and
Simon Bekker-Jensen and
Niels Mailand and
Hannes Lans and
Petra Schwertman and
Audrey M. Gourdin and
Nico P. Dantuma and
Jiri Lukas and
Wim Vermeulen Nucleotide excision repair--induced H2A
ubiquitination is dependent on MDC1 and
RNF8 and reveals a universal DNA damage
response . . . . . . . . . . . . . . . . 835
Kai-Yin Lo and
Zhihua Li and
Feng Wang and
Edward M. Marcotte and
Arlen W. Johnson Ribosome stalk assembly requires the
dual-specificity phosphatase Yvh1 for
the exchange of Mrt4 with P0 . . . . . . 849
Stefan Kemmler and
Laura Occhipinti and
Maria Veisu and
Vikram Govind Panse Yvh1 is required for a late maturation
step in the 60S biogenesis pathway . . . 863
Stacey L. Edwards and
Nicole K. Charlie and
Janet E. Richmond and
Jan Hegermann and
Stefan Eimer and
Kenneth G. Miller Impaired dense core vesicle maturation
in \bionameCaenorhabditis elegans
mutants lacking Rab2 . . . . . . . . . . 881
Marija Sumakovic and
Jan Hegermann and
Ling Luo and
Steven J. Husson and
Katrin Schwarze and
Christian Olendrowitz and
Liliane Schoofs and
Janet Richmond and
Stefan Eimer UNC-108\slash RAB-2 and its effector
RIC-19 are involved in dense core
vesicle maturation in
\bionameCaenorhabditis elegans . . . . . 897
Roberta B. Nowak and
Robert S. Fischer and
Rebecca K. Zoltoski and
Jerome R. Kuszak and
Velia M. Fowler Tropomodulin1 is required for membrane
skeleton organization and hexagonal
geometry of fiber cells in the mouse
lens . . . . . . . . . . . . . . . . . . 915
Daniel J. Anderson and
Jesse D. Vargas and
Joshua P. Hsiao and
Martin W. Hetzer Recruitment of functionally distinct
membrane proteins to chromatin mediates
nuclear envelope formation in vivo . . . 929
Ben Short A MUG shot of spindle assembly . . . . . ??
Ben Short Autophagy balances a Highwire act in
synapse development . . . . . . . . . . ??
Ben Short Merkel cells bear the touch of epidermis ??
Mitch Leslie Myosins pull together --- separately . . 3
Kendall Powell Irina Conboy: Making the old feel young
again . . . . . . . . . . . . . . . . . 4
Mark L. McCleland and
Antony W. Shermoen and
Patrick H. O'Farrell DNA replication times the cell cycle and
contributes to the mid-blastula
transition in \bionameDrosophila embryos 7
Kevin D. Smith and
Michael A. Fu and
Eric J. Brown Tim--Tipin dysfunction creates an
indispensible reliance on the ATR--Chk1
pathway for continued DNA synthesis . . 15
Jeffrey R. Skaar and
Derek J. Richard and
Anita Saraf and
Alfredo Toschi and
Emma Bolderson and
Laurence Florens and
Michael P. Washburn and
Kum Kum Khanna and
Michele Pagano INTS3 controls the hSSB1-mediated DNA
damage response . . . . . . . . . . . . 25
Wei Li and
Leah R. DeBella and
Tugba Guven-Ozkan and
Rueyling Lin and
Lesilee S. Rose An eIF4E-binding protein regulates
katanin protein levels in \bionameC.
elegans embryos . . . . . . . . . . . . 33
Christopher B. O'Connell and
Jadranka Lon\vcarek and
Petr Kaláb and
Alexey Khodjakov Relative contributions of chromatin and
kinetochores to mitotic spindle assembly 43
Sivaraj Sivaramakrishnan and
James A. Spudich Coupled myosin VI motors facilitate
unidirectional movement on an F-actin
network . . . . . . . . . . . . . . . . 53
Mohamed Lamkanfi and
James L. Mueller and
Alberto C. Vitari and
Shahram Misaghi and
Anna Fedorova and
Kurt Deshayes and
Wyne P. Lee and
Hal M. Hoffman and
Vishva M. Dixit Glyburide inhibits the Cryopyrin/Nalp3
inflammasome . . . . . . . . . . . . . . 61
Wei Shen and
Barry Ganetzky Autophagy promotes synapse development
in \bionameDrosophila . . . . . . . . . 71
Benjamin D. Engel and
William B. Ludington and
Wallace F. Marshall Intraflagellar transport particle size
scales inversely with flagellar length:
revisiting the balance-point length
control model . . . . . . . . . . . . . 81
Alexandra Van Keymeulen and
Guilhem Mascre and
Khalil Kass Youseff and
Itamar Harel and
Cindy Michaux and
Natalie De Geest and
Caroline Szpalski and
Younes Achouri and
Wilhelm Bloch and
Bassem A. Hassan and
Cédric Blanpain Epidermal progenitors give rise to
Merkel cells during embryonic
development and adult homeostasis . . . 91
Catherine M. Massaro and
Jan Pielage and
Graeme W. Davis Molecular mechanisms that enhance
synapse stability despite persistent
disruption of the
spectrin/ankyrin/microtubule
cytoskeleton . . . . . . . . . . . . . . 101
Stephen J. Warner and
Gregory D. Longmore Cdc42 antagonizes Rho1 activity at
adherens junctions to limit epithelial
cell apical tension . . . . . . . . . . 119
Gaia Pigino and
Stefan Geimer and
Salvatore Lanzavecchia and
Eugenio Paccagnini and
Francesca Cantele and
Dennis R. Diener and
Joel L. Rosenbaum and
Pietro Lupetti Electron-tomographic analysis of
intraflagellar transport particle trains
in situ . . . . . . . . . . . . . . . . 135
Kendall Powell Walking a fine caspase line . . . . . . ??
Kendall Powell Securing the next generation's
peroxisomes . . . . . . . . . . . . . . ??
Kendall Powell PIKfyve promotes neuron
self-preservation . . . . . . . . . . . ??
Ben Short The different ties that bind . . . . . . 151
Caitlin Sedwick Senthil Muthuswamy: a new road map for
cancer . . . . . . . . . . . . . . . . . 152
Tom Misteli JCB meeting: Cell Biology of Disease . . 155
Juliane C. Kellner and
Pierre A. Coulombe Keratins and protein synthesis: the plot
thickens . . . . . . . . . . . . . . . . 157
Aparna Lakkaraju and
Jose Maria Carvajal-Gonzalez and
Enrique Rodriguez-Boulan It takes two to tango to the melanosome 161
Silvia Canudas and
Susan Smith Differential regulation of telomere and
centromere cohesion by the Scc3
homologues SA1 and SA2, respectively, in
human cells . . . . . . . . . . . . . . 165
Preethi Vijayaraj and
Cornelia Kröger and
Ursula Reuter and
Reinhard Windoffer and
Rudolf E. Leube and
Thomas M. Magin Keratins regulate protein biosynthesis
through localization of GLUT1 and -3
upstream of AMP kinase and Raptor . . . 175
Caroline Adelfalk and
Johannes Janschek and
Ekaterina Revenkova and
Cornelia Blei and
Bodo Liebe and
Eva Göb and
Manfred Alsheimer and
Ricardo Benavente and
Esther de Boer and
Ivana Novak and
Christer Höög and
Harry Scherthan and
Rolf Jessberger Cohesin SMC1$ \beta $ protects telomeres
in meiocytes . . . . . . . . . . . . . . 185
Precious J. Lim and
Rebecca Danner and
Jing Liang and
Howard Doong and
Christine Harman and
Deepa Srinivasan and
Cara Rothenberg and
Hongmin Wang and
Yihong Ye and
Shengyun Fang and
Mervyn J. Monteiro Ubiquilin and p97/VCP bind erasin,
forming a complex involved in ERAD . . . 201
Akiko Koto and
Erina Kuranaga and
Masayuki Miura Temporal regulation of
\bionameDrosophila IAP1 determines
caspase functions in sensory organ
development . . . . . . . . . . . . . . 219
Jinlan Chang and
Fred D. Mast and
Andrei Fagarasanu and
Dorian A. Rachubinski and
Gary A. Eitzen and
Joel B. Dacks and
Richard A. Rachubinski Pex3 peroxisome biogenesis proteins
function in peroxisome inheritance as
class V myosin receptors . . . . . . . . 233
Cédric Delevoye and
Ilse Hurbain and
Dani\`ele Tenza and
Jean-Baptiste Sibarita and
Stéphanie Uzan-Gafsou and
Hiroshi Ohno and
Willie J. C. Geerts and
Arie J. Verkleij and
Jean Salamero and
Michael S. Marks and
Graça Raposo AP-1 and KIF13A coordinate endosomal
sorting and positioning during
melanosome biogenesis . . . . . . . . . 247
Faraz K. Mardakheh and
Mona Yekezare and
Laura M. Machesky and
John K. Heath Spred2 interaction with the late
endosomal protein NBR1 down-regulates
fibroblast growth factor receptor
signaling . . . . . . . . . . . . . . . 265
Fuminori Tsuruta and
Eric M. Green and
Matthieu Rousset and
Ricardo E. Dolmetsch PIKfyve regulates Ca$_V$ 1.2 degradation
and prevents excitotoxic cell death . . 279
Cynthia F. Barber and
Ramon A. Jorquera and
Jan E. Melom and
J. Troy Littleton Postsynaptic regulation of synaptic
plasticity by synaptotagmin 4 requires
both C2 domains . . . . . . . . . . . . 295
Ben Short $ \gamma $-TuRC gives microtubules pause
for thought . . . . . . . . . . . . . . ??
Ben Short Raf-1 sheds then spreads its inhibitions ??
Ben Short Chemosensitivity depends on the
dependency . . . . . . . . . . . . . . . ??
Ben Short Not the average view of adipogenesis . . 315
Nicole LeBrasseur Irving Weissman: Working for
regenerative medicine . . . . . . . . . 316
Troy E. Messick and
Roger A. Greenberg The ubiquitin landscape at DNA
double-strand breaks . . . . . . . . . . 319
Ana\"\is Bouissou and
Christel Vérollet and
Aureliana Sousa and
Paula Sampaio and
Michel Wright and
Claudio E. Sunkel and
Andreas Merdes and
Brigitte Raynaud-Messina $ \gamma $-Tubulin ring complexes
regulate microtubule plus end dynamics 327
Théodora Niault and
Izabela Sobczak and
Katrin Meissl and
Gregory Weitsman and
Daniela Piazzolla and
Gabriele Maurer and
Florian Kern and
Karin Ehrenreiter and
Matthias Hamerl and
Ismail Moarefi and
Thomas Leung and
Oliviero Carugo and
Tony Ng and
Manuela Baccarini From autoinhibition to inhibition in
trans: the Raf-1 regulatory domain
inhibits Rok-$ \alpha $ kinase activity 335
Kazuhide Watanabe and
Tadahiro Nagaoka and
Joseph M. Lee and
Caterina Bianco and
Monica Gonzales and
Nadia P. Castro and
Maria Cristina Rangel and
Kei Sakamoto and
Youping Sun and
Robert Callahan and
David S. Salomon Enhancement of Notch receptor maturation
and signaling sensitivity by Cripto-1 343
Naomi R. Stevens and
Jeroen Dobbelaere and
Alan Wainman and
Fanni Gergely and
Jordan W. Raff Ana3 is a conserved protein required for
the structural integrity of centrioles
and basal bodies . . . . . . . . . . . . 355
Ljiljana Milenkovic and
Matthew P. Scott and
Rajat Rohatgi Lateral transport of Smoothened from the
plasma membrane to the membrane of the
cilium . . . . . . . . . . . . . . . . . 365
Lit-Hsin Loo and
Hai-Jui Lin and
Dinesh K. Singh and
Kathleen M. Lyons and
Steven J. Altschuler and
Lani F. Wu Heterogeneity in the physiological
states and pharmacological responses of
differentiating 3T3-L1 preadipocytes . . 375
Sara B. C. Buonomo and
Yipin Wu and
David Ferguson and
Titia de Lange Mammalian Rif1 contributes to
replication stress survival and
homology-directed repair . . . . . . . . 385
Thibault Courtheoux and
Guillaume Gay and
Yannick Gachet and
Sylvie Tournier Ase1\slash Prc1-dependent spindle
elongation corrects merotely during
anaphase in fission yeast . . . . . . . 399
Yuji Chikashige and
Miho Yamane and
Kasumi Okamasa and
Chihiro Tsutsumi and
Tomoko Kojidani and
Mamiko Sato and
Tokuko Haraguchi and
Yasushi Hiraoka Membrane proteins Bqt3 and -4 anchor
telomeres to the nuclear envelope to
ensure chromosomal bouquet formation . . 413
Joslyn K. Brunelle and
Jeremy Ryan and
Derek Yecies and
Joseph T. Opferman and
Anthony Letai MCL-$1$-dependent leukemia cells are
more sensitive to chemotherapy than
BCL-2-dependent counterparts . . . . . . 429
Ben Short Cohesin pathway makes the necessary
arrangements . . . . . . . . . . . . . . ??
Ben Short Germ cells decide for themselves . . . . ??
Ben Short Sizing up the ER stress response . . . . ??
Ben Short Adhering to the message . . . . . . . . 445
Caitlin Sedwick Michael Buszczak: Tracking the big game
in stem cell identity . . . . . . . . . 446
Scott Emr and
Benjamin S. Glick and
Adam D. Linstedt and
Jennifer Lippincott-Schwartz and
Alberto Luini and
Vivek Malhotra and
Brad J. Marsh and
Akihiko Nakano and
Suzanne R. Pfeffer and
Catherine Rabouille and
James E. Rothman and
Graham Warren and
Felix T. Wieland Journeys through the Golgi --- taking
stock in a new era . . . . . . . . . . . 449
Scarlett Gard and
William Light and
Bo Xiong and
Tania Bose and
Adrian J. McNairn and
Bethany Harris and
Brian Fleharty and
Chris Seidel and
Jason H. Brickner and
Jennifer L. Gerton Cohesinopathy mutations disrupt the
subnuclear organization of chromatin . . 455
Joanne M. Munck and
Alison M. Motley and
James M. Nuttall and
Ewald H. Hettema A dual function for Pex3p in peroxisome
formation and inheritance . . . . . . . 463
Yoshiki Hayashi and
Satoru Kobayashi and
Hiroshi Nakato Drosophila glypicans regulate the
germline stem cell niche . . . . . . . . 473
David Ll\`eres and
John James and
Sam Swift and
David G. Norman and
Angus I. Lamond Quantitative analysis of chromatin
compaction in living cells using
FLIM--FRET . . . . . . . . . . . . . . . 481
Marco Geymonat and
Adonis Spanos and
Geoffroy de Bettignies and
Steven G. Sedgwick Lte1 contributes to Bfa1 localization
rather than stimulating nucleotide
exchange by Tem1 . . . . . . . . . . . . 497
Zhuoru Wu and
Katherine Luby-Phelps and
Abhijit Bugde and
Laura A. Molyneux and
Bray Denard and
Wen-Hong Li and
Gürol M. Süel and
David L. Garbers Capacity for stochastic self-renewal and
differentiation in mammalian
spermatogonial stem cells . . . . . . . 513
Sebastian Schuck and
William A. Prinz and
Kurt S. Thorn and
Christiane Voss and
Peter Walter Membrane expansion alleviates
endoplasmic reticulum stress
independently of the unfolded protein
response . . . . . . . . . . . . . . . . 525
Nicholas L. Cianciola and
Cathleen R. Carlin Adenovirus RID-$ \alpha $ activates an
autonomous cholesterol regulatory
mechanism that rescues defects linked to
Niemann--Pick disease type C . . . . . . 537
Esther Klaile and
Olga Vorontsova and
Kristmundur Sigmundsson and
Mario M. Müller and
Bernhard B. Singer and
Lars-Göran Öfverstedt and
Stina Svensson and
Ulf Skoglund and
Björn Öbrink The CEACAM1 N-terminal Ig domain
mediates cis- and trans-binding and is
essential for allosteric rearrangements
of CEACAM1 microclusters . . . . . . . . 553
Mario M. Müller and
Esther Klaile and
Olga Vorontsova and
Bernhard B. Singer and
Björn Öbrink Homophilic adhesion and CEACAM1-S
regulate dimerization of CEACAM1-L and
recruitment of SHP-2 and c--Src . . . . 569
Mitch Leslie Aki1 helps centrioles stay tight . . . . ??
Mitch Leslie No copying allowed . . . . . . . . . . . ??
Mitch Leslie Rules of phagocytic attraction . . . . . ??
Mitch Leslie Focal adhesions come unstuck . . . . . . 585
Caitlin Sedwick Frauke Melchior: How SUMO wrestles other
proteins . . . . . . . . . . . . . . . . 586
Karmella A. Haynes and
Pamela A. Silver Eukaryotic systems broaden the scope of
synthetic biology . . . . . . . . . . . 589
Zohra Rahmani and
Mary E. Gagou and
Christophe Lefebvre and
Doruk Emre and
Roger E. Karess Separating the spindle, checkpoint, and
timer functions of BubR1 . . . . . . . . 597
Akito Nakamura and
Hiroyuki Arai and
Naoya Fujita Centrosomal Aki1 and cohesin function in
separase-regulated centriole
disengagement . . . . . . . . . . . . . 607
Raphaël Demonchy and
Thierry Blisnick and
Caroline Deprez and
Géraldine Toutirais and
Céline Loussert and
William Marande and
Philippe Grellier and
Philippe Bastin and
Linda Kohl Kinesin 9 family members perform
separate functions in the trypanosome
flagellum . . . . . . . . . . . . . . . 615
Zeqiang Guan and
Christina M. Hughes and
Settapong Kosiyatrakul and
Paolo Norio and
Ranjan Sen and
Steven Fiering and
C. David Allis and
Eric E. Bouhassira and
Carl L. Schildkraut Decreased replication origin activity in
temporal transition regions . . . . . . 623
Zhenjie Xu and
Hiromi Ogawa and
Paola Vagnarelli and
Jan H. Bergmann and
Damien F. Hudson and
Sandrine Ruchaud and
Tatsuo Fukagawa and
William C. Earnshaw and
Kumiko Samejima INCENP-aurora B interactions modulate
kinase activity and chromosome passenger
complex localization . . . . . . . . . . 637
Xiaoli Wang and
Roger A. Herr and
Martijn Rabelink and
Rob C. Hoeben and
Emmanuel J. H. J. Wiertz and
Ted H. Hansen Ube2j2 ubiquitinates hydroxylated amino
acids on ER-associated degradation
substrates . . . . . . . . . . . . . . . 655
Nadia Rucci and
Anna Rufo and
Marina Alamanou and
Mattia Capulli and
Andrea Del Fattore and
Emma Åhrman and
Daria Capece and
Valeria Iansante and
Francesca Zazzeroni and
Edoardo Alesse and
Dick Heinegård and
Anna Teti The glycosaminoglycan-binding domain of
PRELP acts as a cell type--specific NF-$
\kappa $B inhibitor that impairs
osteoclastogenesis . . . . . . . . . . . 669
Ellen Bellon and
Frank P. Luyten and
Przemko Tylzanowski $ \delta $-EF1 is a negative regulator
of Ihh in the developing growth plate 685
Gregory D. Fairn and
Koji Ogata and
Roberto J. Botelho and
Philip D. Stahl and
Richard A. Anderson and
Pietro De Camilli and
Tobias Meyer and
Shoshana Wodak and
Sergio Grinstein An electrostatic switch displaces
phosphatidylinositol phosphate kinases
from the membrane during phagocytosis 701
Frédéric Saltel and
Eva Mortier and
Vesa P. Hytönen and
Marie-Claude Jacquier and
Pascale Zimmermann and
Viola Vogel and
Wei Liu and
Bernhard Wehrle-Haller New PI(4,5)P$_2$- and membrane proximal
integrin--binding motifs in the talin
head control $ \beta $3-integrin
clustering . . . . . . . . . . . . . . . 715
Ellen J. Ezratty and
Claire Bertaux and
Eugene E. Marcantonio and
Gregg G. Gundersen Clathrin mediates integrin endocytosis
for focal adhesion disassembly in
migrating cells . . . . . . . . . . . . 733
Scarlett Gard and
William Light and
Bo Xiong and
Tania Bose and
Adrian J. McNairn and
Bethany Harris and
Brian Fleharty and
Chris Seidel and
Jason H. Brickner and
Jennifer L. Gerton Cohesinopathy mutations disrupt the
subnuclear organization of chromatin . . 749
Ben Short Genes make their position clear . . . . ??
Ben Short VCP takes out the trash . . . . . . . . ??
Ben Short Membranes enter transfer negotiations ??
Aimee deCathelineau Sculpting the dynein regulatory complex 753
Caitlin Sedwick Tarun Kapoor: In the right position to
study chromosomes . . . . . . . . . . . 754
Julie C. Canman Cytokinetic astralogy . . . . . . . . . 757
Hristelina Ilieva and
Magdalini Polymenidou and
Don W. Cleveland Non-cell autonomous toxicity in
neurodegenerative disorders: ALS and
beyond . . . . . . . . . . . . . . . . . 761
Antonio Cerqueira and
David Santamaría and
Bárbara Martínez-Pastor and
Miriam Cuadrado and
Oscar Fernández-Capetillo and
Mariano Barbacid Overall Cdk activity modulates the DNA
damage response in mammalian cells . . . 773
Yoko Hayashi-Takanaka and
Kazuo Yamagata and
Naohito Nozaki and
Hiroshi Kimura Visualizing histone modifications in
living cells: spatiotemporal dynamics of
H3 phosphorylation during interphase . . 781
Sarah Maerki and
Michael H. Olma and
Titu Staubli and
Patrick Steigemann and
Daniel W. Gerlich and
Manfredo Quadroni and
Izabela Sumara and
Matthias Peter The Cul3--KLHL21 E3 ubiquitin ligase
targets Aurora B to midzone microtubules
in anaphase and is required for
cytokinesis . . . . . . . . . . . . . . 791
Karen J. Meaburn and
Prabhakar R. Gudla and
Sameena Khan and
Stephen J. Lockett and
Tom Misteli Disease-specific gene repositioning in
breast cancer . . . . . . . . . . . . . 801
Hideki Yokoyama and
Sofia Rybina and
Rachel Santarella-Mellwig and
Iain W. Mattaj and
Eric Karsenti ISWI is a RanGTP-dependent MAP required
for chromosome segregation . . . . . . . 813
George von Dassow and
Koen J. C. Verbrugghe and
Ann L. Miller and
Jenny R. Sider and
William M. Bement Action at a distance during cytokinesis 831
Gordon Polevoy and
Ho-Chun Wei and
Raymond Wong and
Zsofia Szentpetery and
Yeun Ju Kim and
Philip Goldbach and
Sarah K. Steinbach and
Tamas Balla and
Julie A. Brill Dual roles for the \bionameDrosophila PI
$4$-kinase Four wheel drive in
localizing Rab11 during cytokinesis . . 847
Valérie Risson and
Laetitia Mazelin and
Mila Roceri and
Hervé Sanchez and
Vincent Moncollin and
Claudine Corneloup and
Hél\`ene Richard-Bulteau and
Alban Vignaud and
Dominique Baas and
Aurélia Defour and
Damien Freyssenet and
Jean-François Tanti and
Yannick Le-Marchand-Brustel and
Bernard Ferrier and
Agn\`es Conjard-Duplany and
Klaas Romanino and
Stéphanie Bauché and
Daniel Hanta\"\i and
Matthias Mueller and
Sara C. Kozma and
George Thomas and
Markus A. Rüegg and
Arnaud Ferry and
Mario Pende and
Xavier Bigard and
Nathalie Koulmann and
Laurent Schaeffer and
Yann-Gaël Gangloff Muscle inactivation of mTOR causes
metabolic and dystrophin defects leading
to severe myopathy . . . . . . . . . . . 859
Jeong-Sun Ju and
Rodrigo A. Fuentealba and
Sara E. Miller and
Erin Jackson and
David Piwnica-Worms and
Robert H. Baloh and
Conrad C. Weihl Valosin-containing protein (VCP) is
required for autophagy and is disrupted
in VCP disease . . . . . . . . . . . . . 875
Timothy A. Schulz and
Mal-Gi Choi and
Sumana Raychaudhuri and
Jason A. Mears and
Rodolfo Ghirlando and
Jenny E. Hinshaw and
William A. Prinz Lipid-regulated sterol transfer between
closely apposed membranes by
oxysterol-binding protein homologues . . 889
Chad G. Pearson and
Daniel P. S. Osborn and
Thomas H. Giddings and
Philip L. Beales and
Mark Winey Basal body stability and ciliogenesis
requires the conserved component Poc1 905
Thomas Heuser and
Milen Raytchev and
Jeremy Krell and
Mary E. Porter and
Daniela Nicastro The dynein regulatory complex is the
nexin link and a major regulatory node
in cilia and flagella . . . . . . . . . 921
Ben Short Opposing motors take the strain . . . . ??
Ben Short IKK cuts both ways in Huntington's
disease . . . . . . . . . . . . . . . . ??
Ben Short BBS proteins run an export business . . ??
Ben Short Mitochondrial proteases strike the right
balance . . . . . . . . . . . . . . . . 937
Ben Short Elaine Fuchs: a love for science that's
more than skin deep . . . . . . . . . . 938
Andrew B. Lassar The p38 MAPK family, a pushmi-pullyu of
skeletal muscle differentiation . . . . 941
Vicente Andrés and
José M. González Role of A-type lamins in signaling,
transcription, and chromatin
organization . . . . . . . . . . . . . . 945
Brian Head and
Lorena Griparic and
Mandana Amiri and
Shilpa Gandre-Babbe and
Alexander M. van der Bliek Inducible proteolytic inactivation of
OPA1 mediated by the OMA1 protease in
mammalian cells . . . . . . . . . . . . 959
Christopher S. Wood and
Karl R. Schmitz and
Nicholas J. Bessman and
Thanuja Gangi Setty and
Kathryn M. Ferguson and
Christopher G. Burd PtdIns4 P recognition by Vps74/GOLPH3
links PtdIns $4$-kinase signaling to
retrograde Golgi trafficking . . . . . . 967
Sairei So and
Anthony J. Davis and
David J. Chen Autophosphorylation at serine 1981
stabilizes ATM at DNA damage sites . . . 977
Mark A. Gillespie and
Fabien Le Grand and
Anthony Scim\`e and
Shihuan Kuang and
Julia von Maltzahn and
Vanessa Seale and
Ana Cuenda and
Jeffrey A. Ranish and
Michael A. Rudnicki p38-$ \gamma $-dependent gene silencing
restricts entry into the myogenic
differentiation program . . . . . . . . 991
Dionisia P. Sideris and
Nikos Petrakis and
Nitsa Katrakili and
Despina Mikropoulou and
Angelo Gallo and
Simone Ciofi-Baffoni and
Lucia Banci and
Ivano Bertini and
Kostas Tokatlidis A novel intermembrane space--targeting
signal docks cysteines onto Mia40 during
mitochondrial oxidative folding . . . . 1007
Sarah Ehses and
Ines Raschke and
Giuseppe Mancuso and
Andrea Bernacchia and
Stefan Geimer and
Daniel Tondera and
Jean-Claude Martinou and
Benedikt Westermann and
Elena I. Rugarli and
Thomas Langer Regulation of OPA1 processing and
mitochondrial fusion by m -AAA protease
isoenzymes and OMA1 . . . . . . . . . . 1023
Peter Geserick and
Mike Hupe and
Maryline Moulin and
W. Wei-Lynn Wong and
Maria Feoktistova and
Beate Kellert and
Harald Gollnick and
John Silke and
Martin Leverkus Cellular IAPs inhibit a cryptic
CD95-induced cell death by limiting RIP1
kinase recruitment . . . . . . . . . . . 1037
Julia von Blume and
Juan M. Duran and
Elena Forlanelli and
Anne-Marie Alleaume and
Mikhail Egorov and
Roman Polishchuk and
Henrik Molina and
Vivek Malhotra Actin remodeling by ADF/cofilin is
required for cargo sorting at the
trans-Golgi network . . . . . . . . . . 1055
Shabeen Ally and
Adam G. Larson and
Kari Barlan and
Sarah E. Rice and
Vladimir I. Gelfand Opposite-polarity motors activate one
another to trigger cargo transport in
live cells . . . . . . . . . . . . . . . 1071
Leslie Michels Thompson and
Charity T. Aiken and
Linda S. Kaltenbach and
Namita Agrawal and
Katalin Illes and
Ali Khoshnan and
Marta Martinez-Vincente and
Montserrat Arrasate and
Jacqueline Gire O'Rourke and
Hasan Khashwji and
Tamas Lukacsovich and
Ya-Zhen Zhu and
Alice L. Lau and
Ashish Massey and
Michael R. Hayden and
Scott O. Zeitlin and
Steven Finkbeiner and
Kim N. Green and
Frank M. LaFerla and
Gillian Bates and
Lan Huang and
Paul H. Patterson and
Donald C. Lo and
Ana Maria Cuervo and
J. Lawrence Marsh and
Joan S. Steffan IKK phosphorylates Huntingtin and
targets it for degradation by the
proteasome and lysosome . . . . . . . . 1083
Chiara Francavilla and
Paola Cattaneo and
Vladimir Berezin and
Elisabeth Bock and
Diletta Ami and
Ario de Marco and
Gerhard Christofori and
Ugo Cavallaro The binding of NCAM to FGFR1 induces a
specific cellular response mediated by
receptor trafficking . . . . . . . . . . 1101
Karl-Ferdinand Lechtreck and
Eric C. Johnson and
Tsuyoshi Sakai and
Deborah Cochran and
Bryan A. Ballif and
John Rush and
Gregory J. Pazour and
Mitsuo Ikebe and
George B. Witman The Chlamydomonas reinhardtii BBSome is
an IFT cargo required for export of
specific signaling proteins from
flagella . . . . . . . . . . . . . . . . 1117
Patricia Melloy and
Shu Shen and
Erin White and
J. Richard McIntosh and
Mark D. Rose Correction: Nuclear fusion during yeast
mating occurs by a three-step pathway 3883
Chiara Francavilla and
Paola Cattaneo and
Vladimir Berezin and
Elisabeth Bock and
Diletta Ami and
Ario de Marco and
Gerhard Christofori and
Ugo Cavallaro Correction: The binding of NCAM to FGFR1
induces a specific cellular response
mediated by receptor trafficking . . . . 1422
Tsutomu Fujito and
Wataru Ikeda and
Shigeki Kakunaga and
Yukiko Minami and
Mihoko Kajita and
Yasuhisa Sakamoto and
Morito Monden and
Yoshimi Takai Correction: Inhibition of cell movement
and proliferation by cell--cell
contact-induced interaction of Necl-5
with nectin-3 . . . . . . . . . . . . . ??
Sebastian Schuck and
William A. Prinz and
Kurt S. Thorn and
Christiane Voss and
Peter Walter Correction: Membrane expansion
alleviates endoplasmic reticulum stress
independently of the unfolded protein
response . . . . . . . . . . . . . . . . ??