Last update:
Sat Aug 31 12:16:16 MDT 2024
Ben Short New function for an old master . . . . . ??
Ben Short Segregating out UbcH10's role in
tumorigenesis . . . . . . . . . . . . . ??
Ben Short Synaptic vesicles are well connected . . ??
Ben Short The integrin reconstruction act . . . . 3
Kendall Powell Pier Paolo Di Fiore: Plumbing the depths
of endocytosis . . . . . . . . . . . . . 4
Ramsey A. Saleem and
John D. Aitchison Systems cell biology of the mitotic
spindle . . . . . . . . . . . . . . . . 7
Peter Friedl and
Katarina Wolf Plasticity of cell migration: a
multiscale tuning model . . . . . . . . 11
John A. Follit and
Lixia Li and
Yvonne Vucica and
Gregory J. Pazour The cytoplasmic tail of fibrocystin
contains a ciliary targeting sequence 21
Andrew M. Hudson and
Lynn Cooley Drosophila Kelch functions with Cullin-3
to organize the ring canal actin
cytoskeleton . . . . . . . . . . . . . . 29
Keman Zhang and
Jingfeng Sha and
Marian L. Harter Activation of Cdc6 by MyoD is associated
with the expansion of quiescent myogenic
satellite cells . . . . . . . . . . . . 39
Gul Civelekoglu-Scholey and
Li Tao and
Ingrid Brust-Mascher and
Roy Wollman and
Jonathan M. Scholey Prometaphase spindle maintenance by an
antagonistic motor-dependent force
balance made robust by a disassembling
lamin--B envelope . . . . . . . . . . . 49
Franco J. Vizeacoumar and
Nydia van Dyk and
Frederick S. Vizeacoumar and
Vincent Cheung and
Jingjing Li and
Yaroslav Sydorskyy and
Nicolle Case and
Zhijian Li and
Alessandro Datti and
Corey Nislow and
Brian Raught and
Zhaolei Zhang and
Brendan Frey and
Kerry Bloom and
Charles Boone and
Brenda J. Andrews Integrating high-throughput genetic
interaction mapping and high-content
screening to explore yeast spindle
morphogenesis . . . . . . . . . . . . . 69
Janine H. van Ree and
Karthik B. Jeganathan and
Liviu Malureanu and
Jan M. van Deursen Overexpression of the E2
ubiquitin--conjugating enzyme UbcH10
causes chromosome missegregation and
tumor formation . . . . . . . . . . . . 83
Wei-Lien Yen and
Takahiro Shintani and
Usha Nair and
Yang Cao and
Brian C. Richardson and
Zhijian Li and
Frederick M. Hughson and
Misuzu Baba and
Daniel J. Klionsky The conserved oligomeric Golgi complex
is involved in double-membrane vesicle
formation during autophagy . . . . . . . 101
Yunling Xu and
Li Yuan and
Judy Mak and
Luc Pardanaud and
Maresa Caunt and
Ian Kasman and
Bruno Larrivée and
Raquel del Toro and
Steven Suchting and
Alexander Medvinsky and
Jillian Silva and
Jian Yang and
Jean-Léon Thomas and
Alexander W. Koch and
Kari Alitalo and
Anne Eichmann and
Anil Bagri Neuropilin-2 mediates VEGF--C--induced
lymphatic sprouting together with VEGFR3 115
Christopher Esk and
Chih-Ying Chen and
Ludger Johannes and
Frances M. Brodsky The clathrin heavy chain isoform CHC22
functions in a novel endosomal sorting
step . . . . . . . . . . . . . . . . . . 131
Rubén Fernández-Busnadiego and
Beno\^\it Zuber and
Ulrike Elisabeth Maurer and
Marek Cyrklaff and
Wolfgang Baumeister and
Vladan Lu\vci\'c Quantitative analysis of the native
presynaptic cytomatrix by cryoelectron
tomography . . . . . . . . . . . . . . . 145
Feng Ye and
Guiqing Hu and
Dianne Taylor and
Boris Ratnikov and
Andrey A. Bobkov and
Mark A. McLean and
Stephen G. Sligar and
Kenneth A. Taylor and
Mark H. Ginsberg Recreation of the terminal events in
physiological integrin activation . . . 157
Mitch Leslie Cdks set the replication schedule . . . ??
Mitch Leslie Misfolded proteins go their separate
ways . . . . . . . . . . . . . . . . . . ??
Mitch Leslie FYCO1 gets autophagy on track . . . . . ??
Mitch Leslie An enzyme with self-control . . . . . . 177
Ben Short Kenneth Yamada: Exploring the paths of
cell migration . . . . . . . . . . . . . 178
Benedicte Delaval and
Stephen J. Doxsey Pericentrin in cellular function and
disease . . . . . . . . . . . . . . . . 181
Andrew J. Holland and
Weijie Lan and
Sherry Niessen and
Heather Hoover and
Don W. Cleveland Polo-like kinase 4 kinase activity
limits centrosome overduplication by
autoregulating its own stability . . . . 191
Jeong Su Oh and
Seung Jin Han and
Marco Conti Wee1B, Myt1, and Cdc25 function in
distinct compartments of the mouse
oocyte to control meiotic resumption . . 199
Alexander M. Thomson and
Peter J. Gillespie and
J. Julian Blow Replication factory activation can be
decoupled from the replication timing
program by modulating Cdk levels . . . . 209
Riccardo Bernasconi and
Carmela Galli and
Verena Calanca and
Toshihiro Nakajima and
Maurizio Molinari Stringent requirement for HRD1, SEL1L,
and OS-9/XTP3-B for disposal of
ERAD--L$_S$ substrates . . . . . . . . . 223
Yi Xiang and
Yanzhuang Wang GRASP55 and GRASP65 play complementary
and essential roles in Golgi cisternal
stacking . . . . . . . . . . . . . . . . 237
Serhiy Pankiv and
Endalkachew A. Alemu and
Andreas Brech and
Jack-Ansgar Bruun and
Trond Lamark and
Aud Òvervatn and
Geir Bjòrkòy and
Terje Johansen FYCO1 is a Rab7 effector that binds to
LC3 and PI3P to mediate microtubule plus
end--directed vesicle transport . . . . 253
Armela Joset and
Dana A. Dodd and
Simon Halegoua and
Martin E. Schwab Pincher-generated Nogo--A endosomes
mediate growth cone collapse and
retrograde signaling . . . . . . . . . . 271
Maxime F. Fournier and
Roger Sauser and
Davide Ambrosi and
Jean-Jacques Meister and
Alexander B. Verkhovsky Force transmission in migrating cells 287
Ben Short EGF takes dual control of mRNA . . . . . ??
Ben Short A SOLO performance in meiotic cohesion ??
Ben Short Identifying the prime suspects in
vesicle release . . . . . . . . . . . . ??
Ben Short p53 hides a multitude of CIN . . . . . . 301
Nicole LeBrasseur Wolf Reik: Inheritance beyond DNA . . . 302
S. Y. Christin Chong and
Jonah R. Chan Tapping into the glial reservoir: cells
committed to remaining uncommitted . . . 305
Naomi R. Stevens and
Jeroen Dobbelaere and
Kathrin Brunk and
Anna Franz and
Jordan W. Raff Drosophila Ana2 is a conserved centriole
duplication factor . . . . . . . . . . . 313
Nien-Pei Tsai and
Ya-Lun Lin and
Yao-Chen Tsui and
Li-Na Wei Dual action of epidermal growth factor:
extracellular signal-stimulated
nuclear--cytoplasmic export and
coordinated translation of selected
messenger RNA . . . . . . . . . . . . . 325
Rihui Yan and
Sharon E. Thomas and
Jui-He Tsai and
Yukihiro Yamada and
Bruce D. McKee SOLO: a meiotic protein required for
centromere cohesion, coorientation, and
SMC1 localization in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 335
Cornelia König and
Hiromi Maekawa and
Elmar Schiebel Mutual regulation of cyclin-dependent
kinase and the mitotic exit network . . 351
Sarah L. Thompson and
Duane A. Compton Proliferation of aneuploid human cells
is limited by a p53-dependent mechanism 369
András Masszi and
Pam Speight and
Emmanuel Charbonney and
Monika Lodyga and
Hiroyasu Nakano and
Katalin Szászi and
András Kapus Fate-determining mechanisms in
epithelial--myofibroblast transition:
major inhibitory role for Smad3 . . . . 383
Alexander M. Walter and
Katrin Wiederhold and
Dieter Bruns and
Dirk Fasshauer and
Jakob B. Sòrensen Synaptobrevin N-terminally bound to
syntaxin--SNAP--25 defines the primed
vesicle state in regulated exocytosis 401
Arun Anantharam and
Bibiana Onoa and
Robert H. Edwards and
Ronald W. Holz and
Daniel Axelrod Localized topological changes of the
plasma membrane upon exocytosis
visualized by polarized TIRFM . . . . . 415
Atsushi Tamada and
Satoshi Kawase and
Fujio Murakami and
Hiroyuki Kamiguchi Autonomous right-screw rotation of
growth cone filopodia drives neurite
turning . . . . . . . . . . . . . . . . 429
Sairei So and
Anthony J. Davis and
David J. Chen Autophosphorylation at serine 1981
stabilizes ATM at DNA damage sites . . . 443
Ben Short Plakophilin 1 is found in translation ??
Ben Short p53 strands cell cycle on archipelago ??
Ben Short Unpacking condensins' function in ES
cells . . . . . . . . . . . . . . . . . ??
Ben Short Glycosphingolipids keep signaling in
top--Notch condition . . . . . . . . . . 447
Caitlin Sedwick Graham Warren: Gaining ground on the
Golgi . . . . . . . . . . . . . . . . . 448
Suzanne R. Pfeffer Unconventional secretion by
autophagosome exocytosis . . . . . . . . 451
Christian Conrad and
Daniel W. Gerlich Automated microscopy for high-content
RNAi screening . . . . . . . . . . . . . 453
Annika Wolf and
Malgorzata Krause-Gruszczynska and
Olaf Birkenmeier and
Antje Ostareck-Lederer and
Stefan Hüttelmaier and
Mechthild Hatzfeld Plakophilin 1 stimulates translation by
promoting eIF4A1 activity . . . . . . . 463
Sudip Mandal and
William A. Freije and
Preeta Guptan and
Utpal Banerjee Metabolic control of G1--S transition:
cyclin E degradation by p53-induced
activation of the ubiquitin--proteasome
system . . . . . . . . . . . . . . . . . 473
Jesse C. Gatlin and
Alexandre Matov and
Gaudenz Danuser and
Timothy J. Mitchison and
Edward D. Salmon Directly probing the mechanical
properties of the spindle and its matrix 481
Thomas G. Fazzio and
Barbara Panning Condensin complexes regulate mitotic
progression and interphase chromatin
structure in embryonic stem cells . . . 491
Sebastian Deeg and
Mathias Gralle and
Kamila Sroka and
Mathias Bähr and
Fred Silvester Wouters and
Pawel Kermer BAG1 restores formation of functional
DJ-1 L166P dimers and DJ-1 chaperone
activity . . . . . . . . . . . . . . . . 505
Neena S. Rane and
Oishee Chakrabarti and
Lionel Feigenbaum and
Ramanujan S. Hegde Signal sequence insufficiency
contributes to neurodegeneration caused
by transmembrane prion protein . . . . . 515
Juan M. Duran and
Christophe Anjard and
Chris Stefan and
William F. Loomis and
Vivek Malhotra Unconventional secretion of Acb1 is
mediated by autophagosomes . . . . . . . 527
Ravi Manjithaya and
Christophe Anjard and
William F. Loomis and
Suresh Subramani Unconventional secretion of Pichia
pastoris Acb1 is dependent on GRASP
protein, peroxisomal functions, and
autophagosome formation . . . . . . . . 537
Mirkka Koivusalo and
Christopher Welch and
Hisayoshi Hayashi and
Cameron C. Scott and
Moshe Kim and
Todd Alexander and
Nicolas Touret and
Klaus M. Hahn and
Sergio Grinstein Amiloride inhibits macropinocytosis by
lowering submembranous pH and preventing
Rac1 and Cdc42 signaling . . . . . . . . 547
David Owald and
Wernher Fouquet and
Manuela Schmidt and
Carolin Wichmann and
Sara Mertel and
Harald Depner and
Frauke Christiansen and
Christina Zube and
Christine Quentin and
Jorg Körner and
Henning Urlaub and
Karl Mechtler and
Stephan J. Sigrist A Syd-1 homologue regulates pre- and
postsynaptic maturation in
\bionameDrosophila . . . . . . . . . . . 565
Sophie Hamel and
Jacques Fantini and
François Schweisguth Notch ligand activity is modulated by
glycosphingolipid membrane composition
in \bionameDrosophila melanogaster . . . 581
Tom T. Chen and
Alfonso Luque and
Sunyoung Lee and
Sean M. Anderson and
Tatiana Segura and
M. Luisa Iruela-Arispe Anchorage of VEGF to the extracellular
matrix conveys differential signaling
responses to endothelial cells . . . . . 595
Zhenjie Xu and
Hiromi Ogawa and
Paola Vagnarelli and
Jan H. Bergmann and
Damien F. Hudson and
Sandrine Ruchaud and
Tatsuo Fukagawa and
William C. Earnshaw and
Kumiko Samejima INCENP-aurora B interactions modulate
kinase activity and chromosome passenger
complex localization . . . . . . . . . . 611
Mitch Leslie Tangled DNA tightens chromosomes . . . . ??
Mitch Leslie SENP6 cuts SUMOs down to size . . . . . ??
Mitch Leslie Neighbors limit cell renovations . . . . ??
Mitch Leslie Centrosomes remember which way is up . . 615
Caitlin Sedwick Isabelle Vernos: Motoring around the
mitotic spindle . . . . . . . . . . . . 616
Tom Misteli New editorial board members 2010 . . . . 619
Christine Sütterlin and
Antonino Colanzi The Golgi and the centrosome: building a
functional partnership . . . . . . . . . 621
Halfdan Beck and
Viola Nähse and
Marie Sofie Yoo Larsen and
Petra Groth and
Trevor Clancy and
Michael Lees and
Mette Jòrgensen and
Thomas Helleday and
Randi G. Syljuåsen and
Claus Storgaard Sòrensen Regulators of cyclin-dependent kinases
are crucial for maintaining genome
integrity in S phase . . . . . . . . . . 629
Carolyn J. McNees and
Agueda M. Tejera and
Paula Martínez and
Matilde Murga and
Francisca Mulero and
Oscar Fernandez-Capetillo and
Maria A. Blasco ATR suppresses telomere fragility and
recombination but is dispensable for
elongation of short telomeres by
telomerase . . . . . . . . . . . . . . . 639
Ryo Kawamura and
Lisa H. Pope and
Morten O. Christensen and
Mingxuan Sun and
Ksenia Terekhova and
Fritz Boege and
Christian Mielke and
Anni H. Andersen and
John F. Marko Mitotic chromosomes are constrained by
topoisomerase II--sensitive DNA
entanglements . . . . . . . . . . . . . 653
Khuloud Jaqaman and
Emma M. King and
Ana C. Amaro and
Jennifer R. Winter and
Jonas F. Dorn and
Hunter L. Elliott and
Nunu Mchedlishvili and
Sarah E. McClelland and
Iain M. Porter and
Markus Posch and
Alberto Toso and
Gaudenz Danuser and
Andrew D. McAinsh and
Patrick Meraldi and
Jason R. Swedlow Kinetochore alignment within the
metaphase plate is regulated by
centromere stiffness and microtubule
depolymerases . . . . . . . . . . . . . 665
Debaditya Mukhopadhyay and
Alexei Arnaoutov and
Mary Dasso The SUMO protease SENP6 is essential for
inner kinetochore assembly . . . . . . . 681
Jens Januschke and
Cayetano Gonzalez The interphase microtubule aster is a
determinant of asymmetric division
orientation in \bionameDrosophila
neuroblasts . . . . . . . . . . . . . . 693
Kazue Kanehara and
Wei Xie and
Davis T. W. Ng Modularity of the Hrd1 ERAD complex
underlies its diverse client range . . . 707
Sungsu Kim and
Yogesh P. Wairkar and
Richard W. Daniels and
Aaron DiAntonio The novel endosomal membrane protein Ema
interacts with the class C Vps--HOPS
complex to promote endosomal maturation 717
Adam C. Martin and
Michael Gelbart and
Rodrigo Fernandez-Gonzalez and
Matthias Kaschube and
Eric F. Wieschaus Integration of contractile forces during
tissue invagination . . . . . . . . . . 735
Ben Short A team of rivals at the kinetochore . . ??
Ben Short Disuse TWEAKs muscle loss . . . . . . . ??
Ben Short Arf and Miz1 cause cells to lose their
grip . . . . . . . . . . . . . . . . . . ??
Ben Short Actin oligomers hit the assembly line 753
Caitlin Sedwick Doug Hilton: At home with blood cell
biology . . . . . . . . . . . . . . . . 754
Carolyn S. Sevier New insights into oxidative folding . . 757
Erkki Ruoslahti and
Sangeeta N. Bhatia and
Michael J. Sailor Targeting of drugs and nanoparticles to
tumors . . . . . . . . . . . . . . . . . 759
Voytek Okreglak and
David G. Drubin Loss of Aip1 reveals a role in
maintaining the actin monomer pool and
an in vivo oligomer assembly pathway . . 769
J. Kim Holloway and
Meisha A. Morelli and
Peter L. Borst and
Paula E. Cohen Mammalian BLM helicase is critical for
integrating multiple pathways of meiotic
recombination . . . . . . . . . . . . . 779
Tomomi Kiyomitsu and
Osamu Iwasaki and
Chikashi Obuse and
Mitsuhiro Yanagida Inner centromere formation requires
hMis14, a trident kinetochore protein
that specifically recruits HP1 to human
chromosomes . . . . . . . . . . . . . . 791
Dan Liu and
Mathijs Vleugel and
Chelsea B. Backer and
Tetsuya Hori and
Tatsuo Fukagawa and
Iain M. Cheeseman and
Michael A. Lampson Regulated targeting of protein
phosphatase 1 to the outer kinetochore
by KNL1 opposes Aurora B kinase . . . . 809
Ester Zito and
King-Tung Chin and
Jaime Blais and
Heather P. Harding and
David Ron ERO1-$ \beta $, a pancreas-specific
disulfide oxidase, promotes insulin
biogenesis and glucose homeostasis . . . 821
Ashwani Mittal and
Shephali Bhatnagar and
Akhilesh Kumar and
Estelle Lach-Trifilieff and
Sandrine Wauters and
Hong Li and
Denys Y. Makonchuk and
David J. Glass and
Ashok Kumar The TWEAK--Fn14 system is a critical
regulator of denervation-induced
skeletal muscle atrophy in mice . . . . 833
Bernhard Gillissen and
Jana Wendt and
Antje Richter and
Anja Richter and
Annika Müer and
Tim Overkamp and
Nina Gebhardt and
Robert Preissner and
Claus Belka and
Bernd Dörken and
Peter T. Daniel Endogenous Bak inhibitors Mcl-1 and
Bcl-x$_L$: differential impact on TRAIL
resistance in Bax-deficient carcinoma 851
Robert J. Cain and
Bart Vanhaesebroeck and
Anne J. Ridley The PI3K p110$ \alpha $ isoform
regulates endothelial adherens junctions
via Pyk2 and Rac1 . . . . . . . . . . . 863
Ana M. Pasapera and
Ian C. Schneider and
Erin Rericha and
David D. Schlaepfer and
Clare M. Waterman Myosin II activity regulates vinculin
recruitment to focal adhesions through
FAK-mediated paxillin phosphorylation 877
Janet A. Askari and
Christopher J. Tynan and
Stephen E. D. Webb and
Marisa L. Martin-Fernandez and
Christoph Ballestrem and
Martin J. Humphries Focal adhesions are sites of integrin
extension . . . . . . . . . . . . . . . 891
Barbara Herkert and
Anne Dwertmann and
Steffi Herold and
Mona Abed and
Jean-Francois Naud and
Florian Finkernagel and
Gregory S. Harms and
Amir Orian and
Michael Wanzel and
Martin Eilers The Arf tumor suppressor protein
inhibits Miz1 to suppress cell adhesion
and induce apoptosis . . . . . . . . . . 905
Marcel Mettlen and
Dinah Loerke and
Defne Yarar and
Gaudenz Danuser and
Sandra L. Schmid Cargo- and adaptor-specific mechanisms
regulate clathrin-mediated endocytosis 919
Jingxuan Yang and
Michael Meyer and
Anna-Katharina Müller and
Friederike Böhm and
Richard Grose and
Tina Dauwalder and
Francois Verrey and
Manfred Kopf and
Juha Partanen and
Wilhelm Bloch and
David M. Ornitz and
Sabine Werner Fibroblast growth factor receptors 1 and
2 in keratinocytes control the epidermal
barrier and cutaneous homeostasis . . . 935
Sebiha Cevik and
Yuji Hori and
Oktay I. Kaplan and
Katarzyna Kida and
Tiina Toivenon and
Christian Foley-Fisher and
David Cottell and
Toshiaki Katada and
Kenji Kontani and
Oliver E. Blacque Joubert syndrome Arl13b functions at
ciliary membranes and stabilizes protein
transport in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 953
David D. Sabatini Philip Siekevitz: Bridging biochemistry
and cell biology . . . . . . . . . . . . 3
Mitch Leslie Smooth muscle cells put their best
podosome forward . . . . . . . . . . . . ??
Mitch Leslie Ataxia's double hit . . . . . . . . . . ??
Mitch Leslie IFT proteins go off the rails . . . . . ??
Mitch Leslie Endocytosis takes occludin for a ride 7
Ben Short Daniel Klionsky: a full plate for
autophagy . . . . . . . . . . . . . . . 8
Katrin Karbstein Chaperoning ribosome assembly . . . . . 11
Manuela Quintavalle and
Leonardo Elia and
Gianluigi Condorelli and
Sara A. Courtneidge MicroRNA control of podosome formation
in vascular smooth muscle cells in vivo
and in vitro . . . . . . . . . . . . . . 13
Alexis R. Barr and
John V. Kilmartin and
Fanni Gergely CDK5RAP2 functions in centrosome to
spindle pole attachment and DNA damage
response . . . . . . . . . . . . . . . . 23
Yasuhiro Araki and
Linda Gombos and
Suellen P. S. Migueleti and
Lavanya Sivashanmugam and
Claude Antony and
Elmar Schiebel N-terminal regions of Mps1 kinase
determine functional bifurcation . . . . 41
Ansgar Koplin and
Steffen Preissler and
Yulia Ilina and
Miriam Koch and
Annika Scior and
Marc Erhardt and
Elke Deuerling A dual function for chaperones SSB--RAC
and the NAC nascent
polypeptide--associated complex on
ribosomes . . . . . . . . . . . . . . . 57
Véronique Alban\`ese and
Stefanie Reissmann and
Judith Frydman A ribosome-anchored chaperone network
that facilitates eukaryotic ribosome
biogenesis . . . . . . . . . . . . . . . 69
Caoimhín G. Concannon and
Liam P. Tuffy and
Petronela Weisová and
Helena P. Bonner and
David Dávila and
Caroline Bonner and
Marc C. Devocelle and
Andreas Strasser and
Manus W. Ward and
Jochen H. M. Prehn AMP kinase-mediated activation of the
BH3-only protein Bim couples energy
depletion to stress-induced apoptosis 83
David S. Gokhin and
Raymond A. Lewis and
Caroline R. McKeown and
Roberta B. Nowak and
Nancy E. Kim and
Ryan S. Littlefield and
Richard L. Lieber and
Velia M. Fowler Tropomodulin isoforms regulate thin
filament pointed-end capping and
skeletal muscle physiology . . . . . . . 95
Amanda M. Marchiando and
Le Shen and
W. Vallen Graham and
Christopher R. Weber and
Brad T. Schwarz and
Jotham R. Austin and
David R. Raleigh and
Yanfang Guan and
Alastair J. M. Watson and
Marshall H. Montrose and
Jerrold R. Turner Caveolin-1-dependent occludin
endocytosis is required for TNF-induced
tight junction regulation in vivo . . . 111
Keith E. Szulwach and
Xuekun Li and
Richard D. Smrt and
Yujing Li and
Yuping Luo and
Li Lin and
Nicholas J. Santistevan and
Wendi Li and
Xinyu Zhao and
Peng Jin Cross talk between microRNA and
epigenetic regulation in adult
neurogenesis . . . . . . . . . . . . . . 127
Damaris N. Lorenzo and
Min-gang Li and
Sarah E. Mische and
Karen R. Armbrust and
Laura P. W. Ranum and
Thomas S. Hays Spectrin mutations that cause
spinocerebellar ataxia type 5 impair
axonal transport and induce
neurodegeneration in \bionameDrosophila 143
Jun Kohyama and
Tsukasa Sanosaka and
Akinori Tokunaga and
Eriko Takatsuka and
Keita Tsujimura and
Hideyuki Okano and
Kinichi Nakashima BMP-induced REST regulates the
establishment and maintenance of
astrocytic identity . . . . . . . . . . 159
Tina Sedmak and
Uwe Wolfrum Intraflagellar transport molecules in
ciliary and nonciliary cells of the
retina . . . . . . . . . . . . . . . . . 171
Sebiha Cevik and
Yuji Hori and
Oktay I. Kaplan and
Katarzyna Kida and
Tiina Toivenon and
Christian Foley-Fisher and
David Cottell and
Toshiaki Katada and
Kenji Kontani and
Oliver E. Blacque Joubert syndrome Arl13b functions at
ciliary membranes and stabilizes protein
transport in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 187
Ben Short Rab35 drives exosome secretion . . . . . ??
Ben Short Epithelial cells on death Rho . . . . . ??
Ben Short MIM gives cells a sense of direction . . ??
Ben Short Deciding what to eat . . . . . . . . . . 191
Caitlin Sedwick Laurie Glimcher: Merging cell biology
and immune function . . . . . . . . . . 192
Mike Rossner New style, same substance . . . . . . . 195
Arne Lindqvist Cyclin B--Cdk1 activates its own pump to
get into the nucleus . . . . . . . . . . 197
Tania Bose and
Jennifer L. Gerton Cohesinopathies, gene expression, and
chromatin organization . . . . . . . . . 201
Noriyuki Matsuda and
Shigeto Sato and
Kahori Shiba and
Kei Okatsu and
Keiko Saisho and
Clement A. Gautier and
Yu-shin Sou and
Shinji Saiki and
Sumihiro Kawajiri and
Fumiaki Sato and
Mayumi Kimura and
Masaaki Komatsu and
Nobutaka Hattori and
Keiji Tanaka PINK1 stabilized by mitochondrial
depolarization recruits Parkin to
damaged mitochondria and activates
latent Parkin for mitophagy . . . . . . 211
Chieh Hsu and
Yuichi Morohashi and
Shin-ichiro Yoshimura and
Natalia Manrique-Hoyos and
SangYong Jung and
Marcel A. Lauterbach and
Mostafa Bakhti and
Mads Grònborg and
Wiebke Möbius and
JeongSeop Rhee and
Francis A. Barr and
Mikael Simons Regulation of exosome secretion by Rab35
and its GTPase-activating proteins
TBC1D10A--C . . . . . . . . . . . . . . 223
Christopher Van and
Shan Yan and
W. Matthew Michael and
Shou Waga and
Karlene A. Cimprich Continued primer synthesis at stalled
replication forks contributes to
checkpoint activation . . . . . . . . . 233
Olivier Gavet and
Jonathon Pines Activation of cyclin B1--Cdk1
synchronizes events in the nucleus and
the cytoplasm at mitosis . . . . . . . . 247
Alexander E. Davies and
Kenneth B. Kaplan Hsp90--Sgt1 and Skp1 target human Mis12
complexes to ensure efficient formation
of kinetochore--microtubule binding
sites . . . . . . . . . . . . . . . . . 261
Zhen Zheng and
Huabin Zhu and
Qingwen Wan and
Jing Liu and
Zhuoni Xiao and
David P. Siderovski and
Quansheng Du LGN regulates mitotic spindle
orientation during epithelial
morphogenesis . . . . . . . . . . . . . 275
Gabrielle Haas and
Joerg E. Braun and
Cátia Igreja and
Felix Tritschler and
Tadashi Nishihara and
Elisa Izaurralde HPat provides a link between
deadenylation and decapping in metazoa 289
Ravi Manjithaya and
Shveta Jain and
Jean-Claude Farré and
Suresh Subramani A yeast MAPK cascade regulates pexophagy
but not other autophagy pathways . . . . 303
Amanda L. Neisch and
Olga Speck and
Beth Stronach and
Richard G. Fehon Rho1 regulates apoptosis via activation
of the JNK signaling pathway at the
plasma membrane . . . . . . . . . . . . 311
Kohei Yamamizu and
Taichi Matsunaga and
Hideki Uosaki and
Hiroyuki Fukushima and
Shiori Katayama and
Mina Hiraoka-Kanie and
Kohnosuke Mitani and
Jun K. Yamashita Convergence of Notch and $ \beta
$-catenin signaling induces arterial
fate in vascular progenitors . . . . . . 325
Jacqueline M. Benjamin and
Adam V. Kwiatkowski and
Changsong Yang and
Farida Korobova and
Sabine Pokutta and
Tatyana Svitkina and
William I. Weis and
W. James Nelson $ \alpha $E-catenin regulates actin
dynamics independently of
cadherin-mediated cell--cell adhesion 339
Gabriel A. Quinones and
Janet Jin and
Anthony E. Oro I-BAR protein antagonism of endocytosis
mediates directional sensing during
guided cell migration . . . . . . . . . 353
Daniel C. Worth and
Kairbaan Hodivala-Dilke and
Stephen D. Robinson and
Samantha J. King and
Penny E. Morton and
Frank B. Gertler and
Martin J. Humphries and
Maddy Parsons $ \alpha $ v$ \beta $3 integrin
spatially regulates VASP and RIAM to
control adhesion dynamics and migration 369
Mirkka Koivusalo and
Christopher Welch and
Hisayoshi Hayashi and
Cameron C. Scott and
Moshe Kim and
Todd Alexander and
Nicolas Touret and
Klaus M. Hahn and
Sergio Grinstein Amiloride inhibits macropinocytosis by
lowering submembranous pH and preventing
Rac1 and Cdc42 signaling . . . . . . . . 385
Mitch Leslie Unfaithful proteins no problem for DNA
repair . . . . . . . . . . . . . . . . . ??
Mitch Leslie Skeleton key for metastasis . . . . . . ??
Mitch Leslie RALT doubles down on EGFR . . . . . . . ??
Mitch Leslie Peter Pan bone cells undermine skeleton 389
Ben Short Christine Jacobs--Wagner: Drawing the
bacterial organizational chart . . . . . 390
Mike Rossner Updating realistic access . . . . . . . 393
Jyothi Arikkath N-cadherin: stabilizing synapses . . . . 397
Gillian M. Griffiths and
Andy Tsun and
Jane C. Stinchcombe The immunological synapse: a focal point
for endocytosis and exocytosis . . . . . 399
Yupeng Zheng and
Sam John and
James J. Pesavento and
Jennifer R. Schultz-Norton and
R. Louis Schiltz and
Sonjoon Baek and
Ann M. Nardulli and
Gordon L. Hager and
Neil L. Kelleher and
Craig A. Mizzen Histone H1 phosphorylation is associated
with transcription by RNA polymerases I
and II . . . . . . . . . . . . . . . . . 407
Li Chen and
Annalisa Mupo and
Tuong Huynh and
Sara Cioffi and
Matthew Woods and
Chengliu Jin and
Wallace McKeehan and
LuAnn Thompson-Snipes and
Antonio Baldini and
Elizabeth Illingworth Tbx1 regulates Vegfr3 and is required
for lymphatic vessel development . . . . 417
Yasushi Enokido and
Takuya Tamura and
Hikaru Ito and
Anup Arumughan and
Akihiko Komuro and
Hiroki Shiwaku and
Masaki Sone and
Raphaele Foulle and
Hirohide Sawada and
Hiroshi Ishiguro and
Tetsuya Ono and
Miho Murata and
Ichiro Kanazawa and
Nikolai Tomilin and
Kazuhiko Tagawa and
Erich E. Wanker and
Hitoshi Okazawa Mutant huntingtin impairs Ku70-mediated
DNA repair . . . . . . . . . . . . . . . 425
Martijn S. Luijsterburg and
Gesa von Bornstaedt and
Audrey M. Gourdin and
Antonio Z. Politi and
Martijn J. Moné and
Daniël O. Warmerdam and
Joachim Goedhart and
Wim Vermeulen and
Roel van Driel and
Thomas Höfer Stochastic and reversible assembly of a
multiprotein DNA repair complex ensures
accurate target site recognition and
efficient repair . . . . . . . . . . . . 445
Christian Hentrich and
Thomas Surrey Microtubule organization by the
antagonistic mitotic motors kinesin-5
and kinesin-14 . . . . . . . . . . . . . 465
Lori E. Krueger and
Jui-Ching Wu and
Meng-Fu Bryan Tsou and
Lesilee S. Rose LET-99 inhibits lateral posterior
pulling forces during asymmetric spindle
elongation in \bionameC. elegans embryos 481
Alexander Heuck and
Ingrid Fetka and
Daniel N. Brewer and
Daniela Hüls and
Mary Munson and
Ralf-Peter Jansen and
Dierk Niessing The structure of the Myo4p globular tail
and its function in ASH1 mRNA
localization . . . . . . . . . . . . . . 497
Michael L. Sohaskey and
Yebin Jiang and
Jenny J. Zhao and
Andreas Mohr and
Frank Roemer and
Richard M. Harland Osteopotentia regulates osteoblast
maturation, bone formation, and skeletal
integrity in mice . . . . . . . . . . . 511
Christelle Etard and
Urmas Roostalu and
Uwe Strähle Lack of Apobec2-related proteins causes
a dystrophic muscle phenotype in
zebrafish embryos . . . . . . . . . . . 527
Marie Schoumacher and
Robert D. Goldman and
Daniel Louvard and
Danijela M. Vignjevic Actin, microtubules, and vimentin
intermediate filaments cooperate for
elongation of invadopodia . . . . . . . 541
Yuri Frosi and
Sergio Anastasi and
Costanza Ballar\`o and
Giulia Varsano and
Loriana Castellani and
Elena Maspero and
Simona Polo and
Stefano Alem\`a and
Oreste Segatto A two-tiered mechanism of EGFR
inhibition by RALT/MIG6 via kinase
suppression and receptor degradation . . 557
Supachoke Mangmool and
Arun K. Shukla and
Howard A. Rockman $ \beta $-Arrestin-dependent activation
of Ca$^{2+}$ /calmodulin kinase II after
$ \beta_1$ --adrenergic receptor
stimulation . . . . . . . . . . . . . . 573
Pablo Mendez and
Mathias De Roo and
Lorenzo Poglia and
Paul Klauser and
Dominique Muller N-cadherin mediates plasticity-induced
long-term spine stabilization . . . . . 589
Christen G. DiPetrillo and
Elizabeth F. Smith Pcdp1 is a central apparatus protein
that binds Ca$^{2+}$-calmodulin and
regulates ciliary motility . . . . . . . 601
Ben Short Cdc14 in good repair . . . . . . . . . . ??
Ben Short Parkin restrictions for damaged
mitochondria . . . . . . . . . . . . . . ??
Ben Short A turning point for macrophages . . . . ??
Ben Short Kinetochores hang on for the ride . . . 615
Caitlin Sedwick Andy Dillin: Using aging research to
probe biology . . . . . . . . . . . . . 616
Pirta Hotulainen and
Casper C. Hoogenraad Actin in dendritic spines: connecting
dynamics to function . . . . . . . . . . 619
Annamaria Mocciaro and
Eli Berdougo and
Kang Zeng and
Elizabeth Black and
Paola Vagnarelli and
William Earnshaw and
David Gillespie and
Prasad Jallepalli and
Elmar Schiebel Vertebrate cells genetically deficient
for Cdc14A or Cdc14B retain DNA damage
checkpoint proficiency but are impaired
in DNA repair . . . . . . . . . . . . . 631
Fabienne Lampert and
Peter Hornung and
Stefan Westermann The Dam1 complex confers microtubule
plus end--tracking activity to the Ndc80
kinetochore complex . . . . . . . . . . 641
Pierre Romé and
Emilie Montembault and
Nathalie Franck and
Aude Pascal and
David M. Glover and
Régis Giet Aurora A contributes to p150$^{\rm
glued}$ phosphorylation and function
during mitosis . . . . . . . . . . . . . 651
Yi Qin and
Walter H. Meisen and
Yi Hao and
Ian G. Macara Tuba, a Cdc42 GEF, is required for
polarized spindle orientation during
epithelial cyst formation . . . . . . . 661
Joo-Yong Lee and
Yoshito Nagano and
J. Paul Taylor and
Kah Leong Lim and
Tso-Pang Yao Disease-causing mutations in Parkin
impair mitochondrial ubiquitination,
aggregation, and HDAC6-dependent
mitophagy . . . . . . . . . . . . . . . 671
Brian Stramer and
Severina Moreira and
Tom Millard and
Iwan Evans and
Chieh-Yin Huang and
Ola Sabet and
Martin Milner and
Graham Dunn and
Paul Martin and
Will Wood Clasp-mediated microtubule bundling
regulates persistent motility and
contact repulsion in \bionameDrosophila
macrophages in vivo . . . . . . . . . . 681
Yo Sugawara and
Takuhiro Matsumura and
Yuki Takegahara and
Yingji Jin and
Yoshikazu Tsukasaki and
Masatoshi Takeichi and
Yukako Fujinaga Botulinum hemagglutinin disrupts the
intercellular epithelial barrier by
directly binding E-cadherin . . . . . . 691
Markus Finzsch and
Silke Schreiner and
Tatjana Kichko and
Peter Reeh and
Ernst R. Tamm and
Michael R. Bösl and
Dies Meijer and
Michael Wegner Sox10 is required for Schwann cell
identity and progression beyond the
immature Schwann cell stage . . . . . . 701
Jerry F. Tien and
Neil T. Umbreit and
Daniel R. Gestaut and
Andrew D. Franck and
Jeremy Cooper and
Linda Wordeman and
Tamir Gonen and
Charles L. Asbury and
Trisha N. Davis Cooperation of the Dam1 and Ndc80
kinetochore complexes enhances
microtubule coupling and is regulated by
aurora B . . . . . . . . . . . . . . . . 713
Alejo E. Rodriguez-Fraticelli and
Silvia Vergarajauregui and
Dennis J. Eastburn and
Anirban Datta and
Miguel A. Alonso and
Keith Mostov and
Fernando Martín-Belmonte The Cdc42 GEF Intersectin 2 controls
mitotic spindle orientation to form the
lumen during epithelial morphogenesis 725
Nina C. Hubner and
Alexander W. Bird and
Jürgen Cox and
Bianca Splettstoesser and
Peter Bandilla and
Ina Poser and
Anthony Hyman and
Matthias Mann Quantitative proteomics combined with
BAC TransgeneOmics reveals in vivo
protein interactions . . . . . . . . . . 739
Sunglan Chung and
Peter A. Takizawa Multiple Myo4 motors enhance ASH1 mRNA
transport in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 755
Ester Zito and
King-Tung Chin and
Jaime Blais and
Heather P. Harding and
David Ron ERO1-$ \beta $, a pancreas-specific
disulfide oxidase, promotes insulin
biogenesis and glucose homeostasis . . . 769
Ben Short Stress management for mRNAs . . . . . . ??
Ben Short The story of O-glycosylation . . . . . . ??
Ben Short Nebulin doesn't measure up . . . . . . . ??
Ben Short The acid test of v--ATPase function . . 773
Caitlin Sedwick Inke Näthke: The ABCs of APC . . . . . . 774
Melissa Linkert and
Curtis T. Rueden and
Chris Allan and
Jean-Marie Burel and
Will Moore and
Andrew Patterson and
Brian Loranger and
Josh Moore and
Carlos Neves and
Donald MacDonald and
Aleksandra Tarkowska and
Caitlin Sticco and
Emma Hill and
Mike Rossner and
Kevin W. Eliceiri and
Jason R. Swedlow Metadata matters: access to image data
in the real world . . . . . . . . . . . 777
D. Thomas Rutkowski and
Ramanujan S. Hegde Regulation of basal cellular physiology
by the homeostatic unfolded protein
response . . . . . . . . . . . . . . . . 783
Anne Chadrin and
Barbara Hess and
Mabel San Roman and
Xavier Gatti and
Bérang\`ere Lombard and
Damarys Loew and
Yves Barral and
Benoit Palancade and
Valérie Doye Pom33, a novel transmembrane nucleoporin
required for proper nuclear pore complex
distribution . . . . . . . . . . . . . . 795
Je-Hyun Yoon and
Eui-Ju Choi and
Roy Parker Dcp2 phosphorylation by Ste20 modulates
stress granule assembly and mRNA decay
in \bionameSaccharomyces cerevisiae . . 813
Bradley R. Pearse and
Taku Tamura and
Johan C. Sunryd and
Gregory A. Grabowski and
Randal J. Kaufman and
Daniel N. Hebert The role of UDP--Glc: glycoprotein
glucosyltransferase 1 in the maturation
of an obligate substrate prosaposin . . 829
David J. Gill and
Joanne Chia and
Jamie Senewiratne and
Frederic Bard Regulation of O-glycosylation through
Golgi--to--ER relocation of initiation
enzymes . . . . . . . . . . . . . . . . 843
Christopher T. Pappas and
Paul A. Krieg and
Carol C. Gregorio Nebulin regulates actin filament lengths
by a stabilization mechanism . . . . . . 859
Lai Kuan Goh and
Fangtian Huang and
Woong Kim and
Steven Gygi and
Alexander Sorkin Multiple mechanisms collectively
regulate clathrin-mediated endocytosis
of the epidermal growth factor receptor 871
W. Ryan Williamson and
Dong Wang and
Adam S. Haberman and
P. Robin Hiesinger A dual function of V0-ATPase a1 provides
an endolysosomal degradation mechanism
in \bionameDrosophila melanogaster
photoreceptors . . . . . . . . . . . . . 885
Azusa Hotta and
Tomomi Kawakatsu and
Tomoya Nakatani and
Toshitaka Sato and
Chiyuki Matsui and
Taiko Sukezane and
Tsuyoshi Akagi and
Tomoko Hamaji and
Ilya Grigoriev and
Anna Akhmanova and
Yoshimi Takai and
Yuko Mimori-Kiyosue Laminin-based cell adhesion anchors
microtubule plus ends to the epithelial
cell basal cortex through LL5$ \alpha $
/$ \beta $ . . . . . . . . . . . . . . . 901
Ben Short Polyglutamylation makes the cut . . . . ??
Ben Short Deconstructing FAK function . . . . . . ??
Ben Short Acid sphingomyelinase deals the seal . . ??
Ben Short In search of lost timing . . . . . . . . 921
Caitlin Sedwick Joan Brugge: Running rings around cancer 922
Tatsuya Saitoh and
Shizuo Akira Regulation of innate immune responses by
autophagy-related proteins . . . . . . . 925
Katherine Johnston and
Ajit Joglekar and
Tetsuya Hori and
Aussie Suzuki and
Tatsuo Fukagawa and
E. D. Salmon Vertebrate kinetochore protein
architecture: protein copy number . . . 937
Benjamin Lacroix and
Juliette van Dijk and
Nicholas D. Gold and
Julien Guizetti and
Gudrun Aldrian-Herrada and
Krzysztof Rogowski and
Daniel W. Gerlich and
Carsten Janke Tubulin polyglutamylation stimulates
spastin-mediated microtubule severing 945
Xiaofeng Zhao and
Xu Peng and
Shaogang Sun and
Ann Y. J. Park and
Jun-Lin Guan Role of kinase-independent and
-dependent functions of FAK in
endothelial cell survival and barrier
function during embryonic development 955
Junjie Lu and
Feng Li and
Christopher S. Murphy and
Michael W. Davidson and
David M. Gilbert G2 phase chromatin lacks determinants of
replication timing . . . . . . . . . . . 967
Laura A. Buttitta and
Alexia J. Katzaroff and
Bruce A. Edgar A robust cell cycle control mechanism
limits E2F-induced proliferation of
terminally differentiated cells in vivo 981
Hesso Farhan and
Markus W. Wendeler and
Sandra Mitrovic and
Eugenio Fava and
Yael Silberberg and
Roded Sharan and
Marino Zerial and
Hans-Peter Hauri MAPK signaling to the early secretory
pathway revealed by kinase/phosphatase
functional screening . . . . . . . . . . 997
Jennetta W. Hammond and
T. Lynne Blasius and
Virupakshi Soppina and
Dawen Cai and
Kristen J. Verhey Autoinhibition of the kinesin-2 motor
KIF17 via dual intramolecular mechanisms 1013
Christina Tam and
Vincent Idone and
Cecilia Devlin and
Maria Cecilia Fernandes and
Andrew Flannery and
Xingxuan He and
Edward Schuchman and
Ira Tabas and
Norma W. Andrews Exocytosis of acid sphingomyelinase by
wounded cells promotes endocytosis and
plasma membrane repair . . . . . . . . . 1027
Yujie Li and
Qing Wei and
Yuxia Zhang and
Kun Ling and
Jinghua Hu The small GTPases ARL-13 and ARL-3
coordinate intraflagellar transport and
ciliogenesis . . . . . . . . . . . . . . 1039
Mitch Leslie Clathrin teams up to strengthen the
spindle . . . . . . . . . . . . . . . . ??
Mitch Leslie Secret passage to the inner nuclear
membrane . . . . . . . . . . . . . . . . ??
Mitch Leslie Lysosomes don't accentuate the negative ??
Mitch Leslie APC: More than a beta (catenin) blocker 1055
Ben Short Sean Morrison: a root and branch
approach to stem cells . . . . . . . . . 1056
Michael R. Elliott and
Kodi S. Ravichandran Clearance of apoptotic cells:
implications in health and disease . . . 1059
Marlene Oeffinger Joining the interface: a site for Nmd3
association on 60S ribosome subunits . . 1071
Michael Smutny and
Alpha S. Yap Neighborly relations: cadherins and
mechanotransduction . . . . . . . . . . 1075
Jayati Sengupta and
Cyril Bussiere and
Jesper Pallesen and
Matthew West and
Arlen W. Johnson and
Joachim Frank Characterization of the nuclear export
adaptor protein Nmd3 in association with
the 60S ribosomal subunit . . . . . . . 1079
Kyoko Okada and
Francesca Bartolini and
Alexandra M. Deaconescu and
James B. Moseley and
Zvonimir Dogic and
Nikolaus Grigorieff and
Gregg G. Gundersen and
Bruce L. Goode Adenomatous polyposis coli protein
nucleates actin assembly and synergizes
with the formin mDia1 . . . . . . . . . 1087
Chiou-Hong Lin and
Chi-Kuo Hu and
Hsiu-Ming Shih Clathrin heavy chain mediates TACC3
targeting to mitotic spindles to ensure
spindle stability . . . . . . . . . . . 1097
Quint le Duc and
Quanming Shi and
Iris Blonk and
Arnoud Sonnenberg and
Ning Wang and
Deborah Leckband and
Johan de Rooij Vinculin potentiates E-cadherin
mechanosensing and is recruited to
actin-anchored sites within adherens
junctions in a myosin II-dependent
manner . . . . . . . . . . . . . . . . . 1107
Masaoki Kohzaki and
Kana Nishihara and
Kouji Hirota and
Eiichiro Sonoda and
Michio Yoshimura and
Shigeo Ekino and
John E. Butler and
Masami Watanabe and
Thanos D. Halazonetis and
Shunichi Takeda DNA polymerases $ \nu $ and $ \theta $
are required for efficient
immunoglobulin V gene diversification in
chicken . . . . . . . . . . . . . . . . 1117
Gandhi Theerthagiri and
Nathalie Eisenhardt and
Heinz Schwarz and
Wolfram Antonin The nucleoporin Nup188 controls passage
of membrane proteins across the nuclear
pore complex . . . . . . . . . . . . . . 1129
Christopher W. Carroll and
Kirstin J. Milks and
Aaron F. Straight Dual recognition of CENP--A nucleosomes
is required for centromere assembly . . 1143
Yuting Sun and
Yejing Ge and
Jenny Drnevich and
Yong Zhao and
Mark Band and
Jie Chen Mammalian target of rapamycin regulates
miRNA-1 and follistatin in skeletal
myogenesis . . . . . . . . . . . . . . . 1157
Benjamin E. Steinberg and
Kassidy K. Huynh and
Alexandre Brodovitch and
Sabrina Jabs and
Tobias Stauber and
Thomas J. Jentsch and
Sergio Grinstein A cation counterflux supports lysosomal
acidification . . . . . . . . . . . . . 1171
Seung-Hwan Kim and
Antonia H. Holway and
Suzanne Wolff and
Andrew Dillin and
W. Matthew Michael SMK-1/PPH-4.1-mediated silencing of the
CHK-1 response to DNA damage in early
\bionameC. elegans embryos . . . . . . . 1187
Ben Short Long asters rock the spindle . . . . . . ??
Ben Short SPSB2 sets NO limits . . . . . . . . . . ??
Ben Short PIH proteins give dynein arms a hand . . ??
Ben Short Sar1 bends membranes into shape . . . . 3
Caitlin Sedwick David Pellman: Grasping the geometry of
cancer . . . . . . . . . . . . . . . . . 4
Priya Prakash Budde and
Tom Misteli Cell biology beyond the cell . . . . . . 7
Martin Schwander and
Bechara Kachar and
Ulrich Müller The cell biology of hearing . . . . . . 9
Weijie Lan and
Don W. Cleveland A chemical tool box defines mitotic and
interphase roles for Mps1 kinase . . . . 21
Laura Hewitt and
Anthony Tighe and
Stefano Santaguida and
Anne M. White and
Clifford D. Jones and
Andrea Musacchio and
Stephen Green and
Stephen S. Taylor Sustained Mps1 activity is required in
mitosis to recruit O--Mad2 to the
Mad1--C--Mad2 core complex . . . . . . . 25
Kathleen E. Rankin and
Linda Wordeman Long astral microtubules uncouple
mitotic spindles from the cytokinetic
furrow . . . . . . . . . . . . . . . . . 35
Marie E. Bechler and
Anne M. Doody and
Esther Racoosin and
Lin Lin and
Kelvin H. Lee and
William J. Brown The phospholipase complex PAFAH Ib
regulates the functional organization of
the Golgi complex . . . . . . . . . . . 45
Jingshi Shen and
Shailendra S. Rathore and
Lavan Khandan and
James E. Rothman SNARE bundle and syntaxin N-peptide
constitute a minimal complement for
Munc18-1 activation of membrane fusion 55
Ryosuke Yamamoto and
Masafumi Hirono and
Ritsu Kamiya Discrete PIH proteins function in the
cytoplasmic preassembly of different
subsets of axonemal dyneins . . . . . . 65
Stefano Santaguida and
Anthony Tighe and
Anna Morena D'Alise and
Stephen S. Taylor and
Andrea Musacchio Dissecting the role of MPS1 in
chromosome biorientation and the spindle
checkpoint through the small molecule
inhibitor reversine . . . . . . . . . . 73
John Maciejowski and
Kelly A. George and
Marie-Emilie Terret and
Chao Zhang and
Kevan M. Shokat and
Prasad V. Jallepalli Mps1 directs the assembly of Cdc20
inhibitory complexes during interphase
and mitosis to control M phase timing
and spindle checkpoint signaling . . . . 89
Poonam R. Molli and
Da-Qiang Li and
Rozita Bagheri-Yarmand and
Suresh B. Pakala and
Hiroshi Katayama and
Subrata Sen and
Jyoti Iyer and
Jonathan Chernoff and
Ming-Ying Tsai and
Sujit S. Nair and
Rakesh Kumar Arpc1b, a centrosomal protein, is both
an activator and substrate of Aurora A 101
Kimberly R. Long and
Yasunori Yamamoto and
Adam L. Baker and
Simon C. Watkins and
Carolyn B. Coyne and
James F. Conway and
Meir Aridor Sar1 assembly regulates membrane
constriction and ER export . . . . . . . 115
Zhihe Kuang and
Rowena S. Lewis and
Joan M. Curtis and
Yifan Zhan and
Bernadette M. Saunders and
Jeffrey J. Babon and
Tatiana B. Kolesnik and
Andrew Low and
Seth L. Masters and
Tracy A. Willson and
Lukasz Kedzierski and
Shenggen Yao and
Emanuela Handman and
Raymond S. Norton and
Sandra E. Nicholson The SPRY domain--containing SOCS box
protein SPSB2 targets iNOS for
proteasomal degradation . . . . . . . . 129
Adrian Mehlitz and
Sebastian Banhart and
André P. Mäurer and
Alexis Kaushansky and
Andrew G. Gordus and
Julia Zielecki and
Gavin MacBeath and
Thomas F. Meyer Tarp regulates early
\bionameChlamydia-induced host cell
survival through interactions with the
human adaptor protein SHC1 . . . . . . . 143
Mitch Leslie Virus takes the actin express . . . . . ??
Mitch Leslie Mitosis first, DNA repair later . . . . ??
Mitch Leslie Ins and outs of Cdc14 . . . . . . . . . ??
Mitch Leslie Repetitive but not redundant . . . . . . 161
Caitlin Sedwick Sandra Schmid: Collaring endocytosis . . 162
Lothar Schermelleh and
Rainer Heintzmann and
Heinrich Leonhardt A guide to super-resolution fluorescence
microscopy . . . . . . . . . . . . . . . 165
Emily A. Bassett and
Stacey Wood and
Kevan J. Salimian and
Sandya Ajith and
Daniel R. Foltz and
Ben E. Black Epigenetic centromere specification
directs aurora B accumulation but is
insufficient to efficiently correct
mitotic errors . . . . . . . . . . . . . 177
Taro Ohkawa and
Loy E. Volkman and
Matthew D. Welch Actin-based motility drives baculovirus
transit to the nucleus and cell surface 187
Simona Giunta and
Rimma Belotserkovskaya and
Stephen P. Jackson DNA damage signaling in response to
double-strand breaks during mitosis . . 197
Romilde Manzoni and
Francesca Montani and
Clara Visintin and
Fabrice Caudron and
Andrea Ciliberto and
Rosella Visintin Oscillations in Cdc14 release and
sequestration reveal a circuit
underlying mitotic exit . . . . . . . . 209
Shigeko Kawai-Noma and
Chan-Gi Pack and
Tomoko Kojidani and
Haruhiko Asakawa and
Yasushi Hiraoka and
Masataka Kinjo and
Tokuko Haraguchi and
Hideki Taguchi and
Aiko Hirata In vivo evidence for the fibrillar
structures of Sup35 prions in yeast
cells . . . . . . . . . . . . . . . . . 223
Huaqing Cai and
Satarupa Das and
Yoichiro Kamimura and
Yu Long and
Carole A. Parent and
Peter N. Devreotes Ras-mediated activation of the
TORC2--PKB pathway is critical for
chemotaxis . . . . . . . . . . . . . . . 233
Wei-Ting Chao and
Alexes C. Daquinag and
Felicity Ashcroft and
Jeannette Kunz Type I PIPK-$ \alpha $ regulates
directed cell migration by modulating
Rac1 plasma membrane targeting and
activation . . . . . . . . . . . . . . . 247
Shengda Lin and
Lisa M. Baye and
Trudi A. Westfall and
Diane C. Slusarski Wnt5b--Ryk pathway provides directional
signals to regulate gastrulation
movement . . . . . . . . . . . . . . . . 263
Ben Short $ \gamma $-Tubulin keeps the cell
cycling . . . . . . . . . . . . . . . . ??
Ben Short Acetylated microtubules let the ER slide ??
Ben Short Syndecan-3 adds a Notch to its belt . . ??
Ben Short FLIPping the kill switch . . . . . . . . 281
Ben Short Yukiko Goda: Memories are made of this 282
Nirupa Chaudhari and
Stephen D. Roper The cell biology of taste . . . . . . . 285
Naihan Xu and
Nadia Hegarat and
Elizabeth J. Black and
Mary T. Scott and
Helfrid Hochegger and
David A. Gillespie Akt\slash PKB suppresses DNA damage
processing and checkpoint activation in
late G2 . . . . . . . . . . . . . . . . 297
Fubito Nakatsu and
Rushika M. Perera and
Louise Lucast and
Roberto Zoncu and
Jan Domin and
Frank B. Gertler and
Derek Toomre and
Pietro De Camilli The inositol $5$-phosphatase SHIP2
regulates endocytic clathrin-coated pit
dynamics . . . . . . . . . . . . . . . . 307
Tania Nayak and
Heather Edgerton-Morgan and
Tetsuya Horio and
Yi Xiong and
Colin P. De Souza and
Stephen A. Osmani and
Berl R. Oakley $ \gamma $-Tubulin regulates the
anaphase-promoting complex/cyclosome
during interphase . . . . . . . . . . . 317
Yan Shan Ong and
Bor Luen Tang and
Li Shen Loo and
Wanjin Hong p125A exists as part of the mammalian
Sec13/Sec31 COPII subcomplex to
facilitate ER--Golgi transport . . . . . 331
James R. R. Whittle and
Thomas U. Schwartz Structure of the Sec13--Sec16 edge
element, a template for assembly of the
COPII vesicle coat . . . . . . . . . . . 347
Jonathan R. Friedman and
Brant M. Webster and
David N. Mastronarde and
Kristen J. Verhey and
Gia K. Voeltz ER sliding dynamics and
ER--mitochondrial contacts occur on
acetylated microtubules . . . . . . . . 363
Nicolai Fricker and
Joel Beaudouin and
Petra Richter and
Roland Eils and
Peter H. Krammer and
Inna N. Lavrik Model-based dissection of CD95 signaling
dynamics reveals both a pro- and
antiapoptotic role of c--FLIP$_L$ . . . 377
Brian J. Hawkins and
Krishna M. Irrinki and
Karthik Mallilankaraman and
Yu-Chin Lien and
Youjun Wang and
Cunnigaiper D. Bhanumathy and
Ramasamy Subbiah and
Michael F. Ritchie and
Jonathan Soboloff and
Yoshihiro Baba and
Tomohiro Kurosaki and
Suresh K. Joseph and
Donald L. Gill and
Muniswamy Madesh S-glutathionylation activates STIM1 and
alters mitochondrial homeostasis . . . . 391
Michaella Velichkova and
Joe Juan and
Pavan Kadandale and
Steve Jean and
Inês Ribeiro and
Vignesh Raman and
Chris Stefan and
Amy A. Kiger Drosophila Mtm and class II PI3K
coregulate a PI(3)P pool with cortical
and endolysosomal functions . . . . . . 407
Addolorata Pisconti and
D. D. W. Cornelison and
Hugo C. Olguín and
Tiffany L. Antwine and
Bradley B. Olwin Syndecan-3 and Notch cooperate in
regulating adult myogenesis . . . . . . 427
Fanny Jaulin and
Geri Kreitzer KIF17 stabilizes microtubules and
contributes to epithelial morphogenesis
by acting at MT plus ends with EB1 and
APC . . . . . . . . . . . . . . . . . . 443
Nao Hiramoto-Yamaki and
Shingo Takeuchi and
Shuhei Ueda and
Kohei Harada and
Satoshi Fujimoto and
Manabu Negishi and
Hironori Katoh Ephexin4 and EphA2 mediate cell
migration through a RhoG-dependent
mechanism . . . . . . . . . . . . . . . 461
Wei-Ting Chao and
Alexes C. Daquinag and
Felicity Ashcroft and
Jeannette Kunz Type I PIPK-$ \alpha $ regulates
directed cell migration by modulating
Rac1 plasma membrane targeting and
activation . . . . . . . . . . . . . . . 479
Ben Short The cytoplasm gets some new threads . . ??
Ben Short Myosin II contracts out GTPase
activation . . . . . . . . . . . . . . . ??
Ben Short Migrating cells CLIC into gear . . . . . ??
Ben Short Casting the autophagy net . . . . . . . 483
Ben Short Martin Hetzer: Taking the nuclear
membrane beyond the barrier . . . . . . 484
Hai Dang Nguyen and
Anja-Katrin Bielinsky HDM2 ERKs PCNA . . . . . . . . . . . . . 487
Tobias C. Walther and
Matthias Mann Mass spectrometry-based proteomics in
cell biology . . . . . . . . . . . . . . 491
Barbara Di Fiore and
Jonathon Pines How cyclin A destruction escapes the
spindle assembly checkpoint . . . . . . 501
Kohichi Matsunaga and
Eiji Morita and
Tatsuya Saitoh and
Shizuo Akira and
Nicholas T. Ktistakis and
Tetsuro Izumi and
Takeshi Noda and
Tamotsu Yoshimori Autophagy requires endoplasmic reticulum
targeting of the PI3-kinase complex via
Atg14L . . . . . . . . . . . . . . . . . 511
Ioannis P. Nezis and
Bhupendra V. Shravage and
Antonia P. Sagona and
Trond Lamark and
Geir Bjòrkòy and
Terje Johansen and
Tor Erik Rusten and
Andreas Brech and
Eric H. Baehrecke and
Harald Stenmark Autophagic degradation of dBruce
controls DNA fragmentation in nurse
cells during late \bionameDrosophila
melanogaster oogenesis . . . . . . . . . 523
Salvatore J. Cherra and
Scott M. Kulich and
Guy Uechi and
Manimalha Balasubramani and
John Mountzouris and
Billy W. Day and
Charleen T. Chu Regulation of the autophagy protein LC3
by phosphorylation . . . . . . . . . . . 533
Chalongrat Noree and
Brian K. Sato and
Risa M. Broyer and
James E. Wilhelm Identification of novel filament-forming
proteins in \bionameSaccharomyces
cerevisiae and \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 541
Sarah J. Heasman and
Leo M. Carlin and
Susan Cox and
Tony Ng and
Anne J. Ridley Coordinated RhoA signaling at the
leading edge and uropod is required for
T cell transendothelial migration . . . 553
Benjamin E. L. Lauffer and
Cristina Melero and
Paul Temkin and
Cai Lei and
Wanjin Hong and
Tanja Kortemme and
Mark von Zastrow SNX27 mediates PDZ-directed sorting from
endosomes to the plasma membrane . . . . 565
Angela L. Groehler and
Deborah A. Lannigan A chromatin-bound kinase, ERK8, protects
genomic integrity by inhibiting
HDM2-mediated degradation of the DNA
clamp PCNA . . . . . . . . . . . . . . . 575
Wouter van Zon and
Janneke Ogink and
Bas ter Riet and
René H. Medema and
Hein te Riele and
Rob M. F. Wolthuis The APC/C recruits cyclin B1--Cdk1--Cks
in prometaphase before D box recognition
to control mitotic exit . . . . . . . . 587
Tatsuya Suzuki and
Hiroto Izumi and
Mutsuhito Ohno Cajal body surveillance of U snRNA
export complex assembly . . . . . . . . 603
Julio O. Ortiz and
Florian Brandt and
Valério R. F. Matias and
Lau Sennels and
Juri Rappsilber and
Sjors H. W. Scheres and
Matthias Eibauer and
F. Ulrich Hartl and
Wolfgang Baumeister Structure of hibernating ribosomes
studied by cryoelectron tomography in
vitro and in situ . . . . . . . . . . . 613
Vinh Q. Lam and
David Akopian and
Michael Rome and
Doug Henningsen and
Shu-ou Shan Lipid activation of the signal
recognition particle receptor provides
spatial coordination of protein
targeting . . . . . . . . . . . . . . . 623
Ryosuke Minami and
Atsuko Hayakawa and
Hiroki Kagawa and
Yuko Yanagi and
Hideyoshi Yokosawa and
Hiroyuki Kawahara BAG-6 is essential for selective
elimination of defective proteasomal
substrates . . . . . . . . . . . . . . . 637
Anthony Scim\`e and
Vahab D. Soleimani and
C. Florian Bentzinger and
Mark A. Gillespie and
Fabien Le Grand and
Guillaume Grenier and
Lisa Bevilacqua and
Mary-Ellen Harper and
Michael A. Rudnicki Oxidative status of muscle is determined
by p107 regulation of PGC-1$ \alpha $ 651
Chan-Soo Lee and
Chang-Ki Choi and
Eun-Young Shin and
Martin Alexander Schwartz and
Eung-Gook Kim Myosin II directly binds and inhibits
Dbl family guanine nucleotide exchange
factors: a possible link to Rho family
GTPases . . . . . . . . . . . . . . . . 663
Mark T. Howes and
Matthew Kirkham and
James Riches and
Katia Cortese and
Piers J. Walser and
Fiona Simpson and
Michelle M. Hill and
Alun Jones and
Richard Lundmark and
Margaret R. Lindsay and
Delia J. Hernandez-Deviez and
Gordana Hadzic and
Adam McCluskey and
Rumasia Bashir and
Libin Liu and
Paul Pilch and
Harvey McMahon and
Phillip J. Robinson and
John F. Hancock and
Satyajit Mayor and
Robert G. Parton Clathrin-independent carriers form a
high capacity endocytic sorting system
at the leading edge of migrating cells 675
Fei Liu and
Justin D. Mih and
Barry S. Shea and
Alvin T. Kho and
Asma S. Sharif and
Andrew M. Tager and
Daniel J. Tschumperlin Feedback amplification of fibrosis
through matrix stiffening and COX-2
suppression . . . . . . . . . . . . . . 693
Mitch Leslie Unwrapping new histones . . . . . . . . ??
Mitch Leslie Go on, satellite cells, be all that you
can be . . . . . . . . . . . . . . . . . ??
Mitch Leslie With HMGB1's help, cells dine in . . . . ??
Mitch Leslie Sweet recipe for cellular closeness . . 709
Ben Short Mónica Bettencourt--Dias: Centered on
centrioles . . . . . . . . . . . . . . . 710
Heymut Omran NPHP proteins: gatekeepers of the
ciliary compartment . . . . . . . . . . 715
Peter M. Douglas and
Andrew Dillin Protein homeostasis and aging in
neurodegeneration . . . . . . . . . . . 719
Dorthe Helena Larsen and
Catherine Poinsignon and
Thorkell Gudjonsson and
Christoffel Dinant and
Mark R. Payne and
Flurina J. Hari and
Jannie M. Rendtlew Danielsen and
Patrice Menard and
Jette Christensen Sand and
Manuel Stucki and
Claudia Lukas and
Jiri Bartek and
Jens S. Andersen and
Jiri Lukas The chromatin-remodeling factor CHD4
coordinates signaling and repair after
DNA damage . . . . . . . . . . . . . . . 731
Godelieve Smeenk and
Wouter W. Wiegant and
Hans Vrolijk and
Aldo P. Solari and
Albert Pastink and
Haico van Attikum The NuRD chromatin--remodeling complex
regulates signaling and repair of DNA
damage . . . . . . . . . . . . . . . . . 741
Michael P. Krahn and
Johanna Bückers and
Lars Kastrup and
Andreas Wodarz Formation of a Bazooka--Stardust complex
is essential for plasma membrane
polarity in epithelia . . . . . . . . . 751
Paul Sinclair and
Qian Bian and
Matt Plutz and
Edith Heard and
Andrew S. Belmont Dynamic plasticity of large-scale
chromatin structure revealed by
self-assembly of engineered chromosome
regions . . . . . . . . . . . . . . . . 761
Sonja M. Wiedemann and
Silke N. Mildner and
Clemens Bönisch and
Lars Israel and
Andreas Maiser and
Sarah Matheisl and
Tobias Straub and
Rainer Merkl and
Heinrich Leonhardt and
Elisabeth Kremmer and
Lothar Schermelleh and
Sandra B. Hake Identification and characterization of
two novel primate-specific histone H3
variants, H3.X and H3.Y . . . . . . . . 777
Samriddha Ray and
Kazunori Kume and
Sneha Gupta and
Wanzhong Ge and
Mohan Balasubramanian and
Dai Hirata and
Dannel McCollum The mitosis-to-interphase transition is
coordinated by cross talk between the
SIN and MOR pathways in
\bionameSchizosaccharomyces pombe . . . 793
Guillaume Bompard and
Gabriel Rabeharivelo and
Marie Frank and
Julien Cau and
Claude Delsert and
Nathalie Morin Subgroup II PAK-mediated phosphorylation
regulates Ran activity during mitosis 807
Daniel P. Maskell and
Xiao-Wen Hu and
Martin R. Singleton Molecular architecture and assembly of
the yeast kinetochore MIND complex . . . 823
Arsen Petrovic and
Sebastiano Pasqualato and
Prakash Dube and
Veronica Krenn and
Stefano Santaguida and
Davide Cittaro and
Silvia Monzani and
Lucia Massimiliano and
Jenny Keller and
Aldo Tarricone and
Alessio Maiolica and
Holger Stark and
Andrea Musacchio The MIS12 complex is a protein
interaction hub for outer kinetochore
assembly . . . . . . . . . . . . . . . . 835
Marie-Françoise O'Donohue and
Valérie Choesmel and
Marl\`ene Faubladier and
Gwennaële Fichant and
Pierre-Emmanuel Gleizes Functional dichotomy of ribosomal
proteins during the synthesis of
mammalian 40S ribosomal subunits . . . . 853
Jian-Fu Chen and
Yazhong Tao and
Juan Li and
Zhongliang Deng and
Zhen Yan and
Xiao Xiao and
Da-Zhi Wang microRNA-1 and microRNA-206 regulate
skeletal muscle satellite cell
proliferation and differentiation by
repressing Pax7 . . . . . . . . . . . . 867
Daolin Tang and
Rui Kang and
Kristen M. Livesey and
Chun-Wei Cheh and
Adam Farkas and
Patricia Loughran and
George Hoppe and
Marco E. Bianchi and
Kevin J. Tracey and
Herbert J. Zeh and
Michael T. Lotze Endogenous HMGB1 regulates autophagy . . 881
Hung-Hsiang Huang and
Pamela Stanley A testis-specific regulator of complex
and hybrid N-glycan synthesis . . . . . 893
Jamil Kanaani and
Julia Kolibachuk and
Hugo Martinez and
Steinunn Baekkeskov Two distinct mechanisms target GAD67 to
vesicular pathways and presynaptic
clusters . . . . . . . . . . . . . . . . 911
Branch Craige and
Che-Chia Tsao and
Dennis R. Diener and
Yuqing Hou and
Karl-Ferdinand Lechtreck and
Joel L. Rosenbaum and
George B. Witman CEP290 tethers flagellar transition zone
microtubules to the membrane and
regulates flagellar protein content . . 927
Michaella Velichkova and
Joe Juan and
Pavan Kadandale and
Steve Jean and
Inês Ribeiro and
Vignesh Raman and
Chris Stefan and
Amy A. Kiger Drosophila Mtm and class II PI3K
coregulate a PI(3)P pool with cortical
and endolysosomal functions . . . . . . 941
Mitch Leslie Elm1 sparks the SPOC . . . . . . . . . . ??
Ben Short Autophagy membranes held in reserve . . ??
Ben Short $ \alpha $-Synuclein leaves autophagy
feeling compromised . . . . . . . . . . ??
Ben Short $ \beta $-Catenin gets an honorable
discharge . . . . . . . . . . . . . . . 945
Caitlin Sedwick Noboru Mizushima: All about autophagy 946
Daniel B. Rifkin and
Vesna Todorovic Bone matrix to growth factors: location,
location, location . . . . . . . . . . . 949
Ching-Hwa Sung and
Jen-Zen Chuang The cell biology of vision . . . . . . . 953
Roswitha Krick and
Sebastian Bremer and
Evelyn Welter and
Petra Schlotterhose and
Yvonne Muehe and
Eeva-Liisa Eskelinen and
Michael Thumm Cdc48\slash p97 and Shp1/p47 regulate
autophagosome biogenesis in concert with
ubiquitin-like Atg8 . . . . . . . . . . 965
Ayse Koca Caydasi and
Bahtiyar Kurtulmus and
Maria I. L. Orrico and
Astrid Hofmann and
Bashar Ibrahim and
Gislene Pereira Elm1 kinase activates the spindle
position checkpoint kinase Kin4 . . . . 975
Claudio R. Thoma and
Alexandre Matov and
Katrin L. Gutbrodt and
Christian R. Hoerner and
Zlatko Smole and
Wilhelm Krek and
Gaudenz Danuser Quantitative image analysis identifies
pVHL as a key regulator of microtubule
dynamic instability . . . . . . . . . . 991
Muriel Mari and
Janice Griffith and
Ester Rieter and
Lakshmi Krishnappa and
Daniel J. Klionsky and
Fulvio Reggiori An Atg9-containing compartment that
functions in the early steps of
autophagosome biogenesis . . . . . . . . 1005
Ashley R. Winslow and
Chien-Wen Chen and
Silvia Corrochano and
Abraham Acevedo-Arozena and
David E. Gordon and
Andrew A. Peden and
Maike Lichtenberg and
Fiona M. Menzies and
Brinda Ravikumar and
Sara Imarisio and
Steve Brown and
Cahir J. O'Kane and
David C. Rubinsztein $ \alpha $-Synuclein impairs
macroautophagy: implications for
Parkinson's disease . . . . . . . . . . 1023
Cristinel Sandu and
Hyung Don Ryoo and
Hermann Steller Drosophila IAP antagonists form
multimeric complexes to promote cell
death . . . . . . . . . . . . . . . . . 1039
Pei Ching Low and
Ryo Misaki and
Kate Schroder and
Amanda C. Stanley and
Matthew J. Sweet and
Rohan D. Teasdale and
Bart Vanhaesebroeck and
Frédéric A. Meunier and
Tomohiko Taguchi and
Jennifer L. Stow Phosphoinositide $3$-kinase $ \delta $
regulates membrane fission of Golgi
carriers for selective cytokine
secretion . . . . . . . . . . . . . . . 1053
Yuanyuan Liu and
Claudia Schirra and
Ludwig Edelmann and
Ulf Matti and
JeongSeop Rhee and
Detlef Hof and
Dieter Bruns and
Nils Brose and
Heiko Rieger and
David R. Stevens and
Jens Rettig Two distinct secretory vesicle--priming
steps in adrenal chromaffin cells . . . 1067
Arthit Chairoungdua and
Danielle L. Smith and
Pierre Pochard and
Michael Hull and
Michael J. Caplan Exosome release of $ \beta $-catenin: a
novel mechanism that antagonizes Wnt
signaling . . . . . . . . . . . . . . . 1079
Aline Bozec and
Latifa Bakiri and
Maria Jimenez and
Thorsten Schinke and
Michael Amling and
Erwin F. Wagner Fra-2\slash AP-1 controls bone formation
by regulating osteoblast differentiation
and collagen production . . . . . . . . 1093
Harikiran Nistala and
Sui Lee-Arteaga and
Silvia Smaldone and
Gabriella Siciliano and
Luca Carta and
Robert N. Ono and
Gerhard Sengle and
Emilio Arteaga-Solis and
Regis Levasseur and
Patricia Ducy and
Lynn Y. Sakai and
Gerard Karsenty and
Francesco Ramirez Fibrillin-1 and -2 differentially
modulate endogenous TGF-$ \beta $ and
BMP bioavailability during bone
formation . . . . . . . . . . . . . . . 1107
Mitch Leslie Ras makes a pit stop . . . . . . . . . . ??
Mitch Leslie CLIP catches enzymes in the act . . . . ??
Mitch Leslie How a virus enters without breaking . . ??
Mitch Leslie Not all nuclear pores created equal . . 3
Caitlin Sedwick Bettina Winckler: Neuronal polarity on
her mind . . . . . . . . . . . . . . . . 4
Patricia Ducy and
Gerard Karsenty The two faces of serotonin in bone
biology . . . . . . . . . . . . . . . . 7
Elisa Dultz and
Jan Ellenberg Live imaging of single nuclear pores
reveals unique assembly kinetics and
mechanism in interphase . . . . . . . . 15
Ryo Misaki and
Miki Morimatsu and
Takefumi Uemura and
Satoshi Waguri and
Eiji Miyoshi and
Naoyuki Taniguchi and
Michiyuki Matsuda and
Tomohiko Taguchi Palmitoylated Ras proteins traffic
through recycling endosomes to the
plasma membrane during exocytosis . . . 23
Ye Xu and
Yingli Sun and
Xiaofeng Jiang and
Marina K. Ayrapetov and
Patryk Moskwa and
Shenghong Yang and
David M. Weinstock and
Brendan D. Price The p400 ATPase regulates nucleosome
stability and chromatin ubiquitination
during DNA repair . . . . . . . . . . . 31
Ismail Hassan Ismail and
Christi Andrin and
Darin McDonald and
Michael J. Hendzel BMI1-mediated histone ubiquitylation
promotes DNA double-strand break repair 45
Markus Posch and
Guennadi A. Khoudoli and
Sam Swift and
Emma M. King and
Jennifer G. DeLuca and
Jason R. Swedlow Sds22 regulates aurora B activity and
microtubule--kinetochore interactions at
mitosis . . . . . . . . . . . . . . . . 61
Martina Huranová and
Ivan Ivani and
Ale\vs Benda and
Ina Poser and
Yehuda Brody and
Martin Hof and
Yaron Shav-Tal and
Karla M. Neugebauer and
David Stan\vek The differential interaction of snRNPs
with pre-mRNA reveals splicing kinetics
in living cells . . . . . . . . . . . . 75
Cristina Valacca and
Serena Bonomi and
Emanuele Buratti and
Simona Pedrotti and
Francisco Ernesto Baralle and
Claudio Sette and
Claudia Ghigna and
Giuseppe Biamonti Sam68 regulates EMT through alternative
splicing--activated nonsense-mediated
mRNA decay of the SF2/ASF proto-oncogene 87
Anna Raffaello and
Giulia Milan and
Eva Masiero and
Silvia Carnio and
Donghoon Lee and
Gerolamo Lanfranchi and
Alfred Lewis Goldberg and
Marco Sandri JunB transcription factor maintains
skeletal muscle mass and promotes
hypertrophy . . . . . . . . . . . . . . 101
Heidi N. Fridolfsson and
Daniel A. Starr Kinesin-1 and dynein at the nuclear
envelope mediate the bidirectional
migrations of nuclei . . . . . . . . . . 115
Daniel Mesnard and
Daniel B. Constam Imaging proprotein convertase activities
and their regulation in the implanting
mouse blastocyst . . . . . . . . . . . . 129
David U. Mick and
Milena Vukotic and
Heike Piechura and
Helmut E. Meyer and
Bettina Warscheid and
Markus Deckers and
Peter Rehling Coa3 and Cox14 are essential for
negative feedback regulation of COX1
translation in mitochondria . . . . . . 141
Sabrina Di Bartolomeo and
Marco Corazzari and
Francesca Nazio and
Serafina Oliverio and
Gaia Lisi and
Manuela Antonioli and
Vittoria Pagliarini and
Silvia Matteoni and
Claudia Fuoco and
Luigi Giunta and
Marcello D'Amelio and
Roberta Nardacci and
Alessandra Romagnoli and
Mauro Piacentini and
Francesco Cecconi and
Gian Maria Fimia The dynamic interaction of AMBRA1 with
the dynein motor complex regulates
mammalian autophagy . . . . . . . . . . 155
Rebecca W. Scott and
Steven Hooper and
Diane Crighton and
Ang Li and
Ireen König and
June Munro and
Elisabeth Trivier and
Grant Wickman and
Pierre Morin and
Daniel R. Croft and
John Dawson and
Laura Machesky and
Kurt I. Anderson and
Erik A. Sahai and
Michael F. Olson LIM kinases are required for invasive
path generation by tumor and
tumor-associated stromal cells . . . . . 169
Colin P. Johnson and
Edwin R. Chapman Otoferlin is a calcium sensor that
directly regulates SNARE-mediated
membrane fusion . . . . . . . . . . . . 187
Sonia Libersou and
Aurélie A. V. Albertini and
Malika Ouldali and
Virginie Maury and
Christine Maheu and
Hél\`ene Raux and
Felix de Haas and
Stéphane Roche and
Yves Gaudin and
Jean Lepault Distinct structural rearrangements of
the VSV glycoprotein drive membrane
fusion . . . . . . . . . . . . . . . . . 199
Xin Xiong and
Xin Wang and
Ronny Ewanek and
Pavan Bhat and
Aaron DiAntonio and
Catherine A. Collins Protein turnover of the Wallenda/DLK
kinase regulates a retrograde response
to axonal injury . . . . . . . . . . . . 211
Ben Short Augmin-ting the central spindle . . . . ??
Ben Short Rab GEFs emerge from their DENN . . . . ??
Ben Short Gli inhibitor pricked by Hedgehog . . . ??
Ben Short A little Cdc20 goes a long way . . . . . 227
Caitlin Sedwick Jiahuai Han: Aflame on inflammation and
p38 . . . . . . . . . . . . . . . . . . 228
Aimee deCathelineau and
Elizabeth H. Williams and
Tom Misteli and
Mike Rossner Friends, colleagues, authors, lend us
your data . . . . . . . . . . . . . . . 231
Jagesh V. Shah Cells in tight spaces: the role of cell
shape in cell function . . . . . . . . . 233
Ellen A. Lumpkin and
Kara L. Marshall and
Aislyn M. Nelson The cell biology of touch . . . . . . . 237
Liyi Geng and
Catherine J. Huntoon and
Larry M. Karnitz RAD18-mediated ubiquitination of PCNA
activates the Fanconi anemia DNA repair
network . . . . . . . . . . . . . . . . 249
Ryota Uehara and
Gohta Goshima Functional central spindle assembly
requires de novo microtubule generation
in the interchromosomal region during
anaphase . . . . . . . . . . . . . . . . 259
Jens C. Schmidt and
Tomomi Kiyomitsu and
Tetsuya Hori and
Chelsea B. Backer and
Tatsuo Fukagawa and
Iain M. Cheeseman Aurora B kinase controls the targeting
of the Astrin--SKAP complex to
bioriented kinetochores . . . . . . . . 269
Nannette Jelluma and
Tobias B. Dansen and
Tale Sliedrecht and
Nicholas P. Kwiatkowski and
Geert J. P. L. Kops Release of Mps1 from kinetochores is
crucial for timely anaphase onset . . . 281
Giovanni Ciavarra and
Eldad Zacksenhaus Rescue of myogenic defects in
Rb-deficient cells by inhibition of
autophagy or by hypoxia-induced
glycolytic shift . . . . . . . . . . . . 291
Amandine Pitaval and
Qingzong Tseng and
Michel Bornens and
Manuel Théry Cell shape and contractility regulate
ciliogenesis in cell cycle--arrested
cells . . . . . . . . . . . . . . . . . 303
Liviu Malureanu and
Karthik B. Jeganathan and
Fang Jin and
Darren J. Baker and
Janine H. van Ree and
Oliver Gullon and
Zheyan Chen and
John R. Henley and
Jan M. van Deursen Cdc20 hypomorphic mice fail to
counteract de novo synthesis of cyclin
B1 in mitosis . . . . . . . . . . . . . 313
Moe R. Mahjoub and
Zhigang Xie and
Tim Stearns Cep120 is asymmetrically localized to
the daughter centriole and is essential
for centriole assembly . . . . . . . . . 331
Hiroyuki Hirai and
Mayank Verma and
Shuichi Watanabe and
Christopher Tastad and
Yoko Asakura and
Atsushi Asakura MyoD regulates apoptosis of myoblasts
through microRNA-mediated
down-regulation of Pax3 . . . . . . . . 347
Shin-ichiro Yoshimura and
Andreas Gerondopoulos and
Andrea Linford and
Daniel J. Rigden and
Francis A. Barr Family-wide characterization of the DENN
domain Rab GDP--GTP exchange factors . . 367
Anna Brachet and
Christophe Leterrier and
Marie Irondelle and
Marie-Pierre Fache and
Victor Racine and
Jean-Baptiste Sibarita and
Daniel Choquet and
Bénédicte Dargent Ankyrin G restricts ion channel
diffusion at the axonal initial segment
before the establishment of the
diffusion barrier . . . . . . . . . . . 383
Damien Garbett and
David P. LaLonde and
Anthony Bretscher The scaffolding protein EBP50 regulates
microvillar assembly in a
phosphorylation-dependent manner . . . . 397
Hanna Tukachinsky and
Lyle V. Lopez and
Adrian Salic A mechanism for vertebrate Hedgehog
signaling: recruitment to cilia and
dissociation of SuFu--Gli protein
complexes . . . . . . . . . . . . . . . 415
Nirupa Chaudhari and
Stephen D. Roper The cell biology of taste . . . . . . . 429
Mitch Leslie CLIP catches enzymes in the act . . . . 431
Mitch Leslie A MAP holds the corners . . . . . . . . ??
Mitch Leslie dRich doesn't take sides . . . . . . . . ??
Mitch Leslie Cytoplasmic enzymes cast NETs . . . . . ??
Mitch Leslie Helping stem cells make a connection . . 435
Ben Short Maxence Nachury: a transporting view of
the primary cilium . . . . . . . . . . . 436
Robert G. Parton and
Mark T. Howes Revisiting caveolin trafficking: the end
of the caveosome . . . . . . . . . . . . 439
Shannon DeMaria and
John Ngai The cell biology of smell . . . . . . . 443
Masaru Mitsushima and
Kazuhiro Aoki and
Miki Ebisuya and
Shigeru Matsumura and
Takuya Yamamoto and
Michiyuki Matsuda and
Fumiko Toyoshima and
Eisuke Nishida Revolving movement of a dynamic cluster
of actin filaments during mitosis . . . 453
Franck J. Fourniol and
Charles V. Sindelar and
Béatrice Amigues and
Daniel K. Clare and
Geraint Thomas and
Myl\`ene Perderiset and
Fiona Francis and
Anne Houdusse and
Carolyn A. Moores Template-free $ 13$-protofilament
microtubule--MAP assembly visualized at
8 Å resolution . . . . . . . . . . . . . 463
Michael V. D'Ambrosio and
Ronald D. Vale A whole genome RNAi screen of
\bionameDrosophila S2 cell spreading
performed using automated computational
image analysis . . . . . . . . . . . . . 471
Rebecca M. Fox and
Caitlin D. Hanlon and
Deborah J. Andrew The CrebA/Creb3-like transcription
factors are major and direct regulators
of secretory capacity . . . . . . . . . 479
Jeffrey K. Moore and
Prakash Chudalayandi and
Richard A. Heil-Chapdelaine and
John A. Cooper The spindle position checkpoint is
coordinated by the Elm1 kinase . . . . . 493
Jana M. Mitchell and
Jörg Mansfeld and
Juliana Capitanio and
Ulrike Kutay and
Richard W. Wozniak Pom121 links two essential subcomplexes
of the nuclear pore complex core to the
membrane . . . . . . . . . . . . . . . . 505
Fang Yu and
Lu Sun and
Khaled Machaca Constitutive recycling of the
store-operated Ca$^{2+}$ channel Orai1
and its internalization during meiosis 523
Brigit E. Riley and
Stephen E. Kaiser and
Thomas A. Shaler and
Aylwin C. Y. Ng and
Taichi Hara and
Mark S. Hipp and
Kasper Lage and
Ramnik J. Xavier and
Kwon-Yul Ryu and
Keiko Taguchi and
Masayuki Yamamoto and
Keiji Tanaka and
Noboru Mizushima and
Masaaki Komatsu and
Ron R. Kopito Ubiquitin accumulation in
autophagy-deficient mice is dependent on
the Nrf2-mediated stress response
pathway: a potential role for protein
aggregation in autophagic substrate
selection . . . . . . . . . . . . . . . 537
Pirjo M. Apaja and
Haijin Xu and
Gergely L. Lukacs Quality control for unfolded proteins at
the plasma membrane . . . . . . . . . . 553
Scott D. Hansen and
R. Dyche Mullins VASP is a processive actin polymerase
that requires monomeric actin for barbed
end association . . . . . . . . . . . . 571
Jean-Baptiste Manneville and
Muguette Jehanno and
Sandrine Etienne-Manneville Dlg1 binds GKAP to control dynein
association with microtubules,
centrosome positioning, and cell
polarity . . . . . . . . . . . . . . . . 585
Andrew R. Flannery and
Cecilia Czibener and
Norma W. Andrews Palmitoylation-dependent association
with CD63 targets the Ca$^{2+}$ sensor
synaptotagmin VII to lysosomes . . . . . 599
Arnold Hayer and
Miriam Stoeber and
Danilo Ritz and
Sabrina Engel and
Hemmo H. Meyer and
Ari Helenius Caveolin-1 is ubiquitinated and targeted
to intralumenal vesicles in
endolysosomes for degradation . . . . . 615
Dong Li and
Jiaxi Zhou and
Lu Wang and
Myung Eun Shin and
Pei Su and
Xiaohua Lei and
Haibin Kuang and
Weixiang Guo and
Hong Yang and
Linzhao Cheng and
Tetsuya S. Tanaka and
Deborah E. Leckband and
Albert B. Reynolds and
Enkui Duan and
Fei Wang Integrated biochemical and mechanical
signals regulate multifaceted human
embryonic stem cell functions . . . . . 631
Nadim Maghzal and
Emily Vogt and
Wolfgang Reintsch and
James S. Fraser and
François Fagotto The tumor-associated EpCAM regulates
morphogenetic movements through
intracellular signaling . . . . . . . . 645
Minyeop Nahm and
A. Ashleigh Long and
Sang Kyoo Paik and
Sungdae Kim and
Yong Chul Bae and
Kendal Broadie and
Seungbok Lee The Cdc42-selective GAP Rich regulates
postsynaptic development and retrograde
BMP transsynaptic signaling . . . . . . 661
Venizelos Papayannopoulos and
Kathleen D. Metzler and
Abdul Hakkim and
Arturo Zychlinsky Neutrophil elastase and myeloperoxidase
regulate the formation of neutrophil
extracellular traps . . . . . . . . . . 677
Ben Short SRGP-1 drives cell junctions round the
bend . . . . . . . . . . . . . . . . . . ??
Ben Short Cells find an alternative exit . . . . . ??
Ben Short How Vps41 HOPS between tethering
functions . . . . . . . . . . . . . . . ??
Ben Short Cep152 and Plk4 form a double act . . . 695
Caitlin Sedwick Craig Thompson: The method to cancer's
madness . . . . . . . . . . . . . . . . 696
Hansjörg Schwertz and
Andrew S. Weyrich Platelet precursors display bipolar
behavior . . . . . . . . . . . . . . . . 699
Hannah C. Chapin and
Michael J. Caplan The cell biology of polycystic kidney
disease . . . . . . . . . . . . . . . . 701
Yan Hu and
Matt Plutz and
Andrew S. Belmont Hsp70 gene association with nuclear
speckles is Hsp70 promoter specific . . 711
Emily M. Hatch and
Anita Kulukian and
Andrew J. Holland and
Don W. Cleveland and
Tim Stearns Cep152 interacts with Plk4 and is
required for centriole duplication . . . 721
Onur Cizmecioglu and
Marc Arnold and
Ramona Bahtz and
Florian Settele and
Lena Ehret and
Uta Haselmann-Weiß and
Claude Antony and
Ingrid Hoffmann Cep152 acts as a scaffold for
recruitment of Plk4 and CPAP to the
centrosome . . . . . . . . . . . . . . . 731
Mathew P. Estey and
Caterina Di Ciano-Oliveira and
Carol D. Froese and
Margaret T. Bejide and
William S. Trimble Distinct roles of septins in
cytokinesis: SEPT9 mediates midbody
abscission . . . . . . . . . . . . . . . 741
Ricardo Nunes Bastos and
Francis A. Barr Plk1 negatively regulates Cep55
recruitment to the midbody to ensure
orderly abscission . . . . . . . . . . . 751
Ronen Zaidel-Bar and
Michael J. Joyce and
Allison M. Lynch and
Kristen Witte and
Anjon Audhya and
Jeff Hardin The F--BAR domain of SRGP-1 facilitates
cell--cell adhesion during \bionameC.
elegans morphogenesis . . . . . . . . . 761
Alexander Ludwig and
Grant P. Otto and
Kirsi Riento and
Emily Hams and
Padraic G. Fallon and
Ben J. Nichols Flotillin microdomains interact with the
cortical cytoskeleton to control uropod
formation and neutrophil recruitment . . 771
Hyunju Ryu and
Maiko Furuta and
Donald Kirkpatrick and
Steven P. Gygi and
Yoshiaki Azuma PIASy-dependent SUMOylation regulates
DNA topoisomerase II$ \alpha $ activity 783
Jeffrey B. Woodruff and
David G. Drubin and
Georjana Barnes Mitotic spindle disassembly occurs via
distinct subprocesses driven by the
anaphase-promoting complex, Aurora B
kinase, and kinesin-8 . . . . . . . . . 795
Stacey E. Wirt and
Adam S. Adler and
Véronique Gebala and
James M. Weimann and
Bethany E. Schaffer and
Louis A. Saddic and
Patrick Viatour and
Hannes Vogel and
Howard Y. Chang and
Alex Meissner and
Julien Sage G1 arrest and differentiation can occur
independently of Rb family function . . 809
Zhixun Dou and
Mohar Chattopadhyay and
Ji-An Pan and
Jennifer L. Guerriero and
Ya-Ping Jiang and
Lisa M. Ballou and
Zhenyu Yue and
Richard Z. Lin and
Wei-Xing Zong The class IA phosphatidylinositol
$3$-kinase p110-$ \beta $ subunit is a
positive regulator of autophagy . . . . 827
Margarita Cabrera and
Lars Langemeyer and
Muriel Mari and
Ralf Rethmeier and
Ioan Orban and
Angela Perz and
Cornelia Bröcker and
Janice Griffith and
Daniel Klose and
Heinz-Jürgen Steinhoff and
Fulvio Reggiori and
Siegfried Engelbrecht-Vandré and
Christian Ungermann Phosphorylation of a membrane
curvature--sensing motif switches
function of the HOPS subunit Vps41 in
membrane tethering . . . . . . . . . . . 845
Jonathan N. Thon and
Alejandro Montalvo and
Sunita Patel-Hett and
Matthew T. Devine and
Jennifer L. Richardson and
Allen Ehrlicher and
Mark K. Larson and
Karin Hoffmeister and
John H. Hartwig and
Joseph E. Italiano Cytoskeletal mechanics of proplatelet
maturation and platelet release . . . . 861
Martin Distel and
Jennifer C. Hocking and
Katrin Volkmann and
Reinhard W. Köster The centrosome neither persistently
leads migration nor determines the site
of axonogenesis in migrating neurons in
vivo . . . . . . . . . . . . . . . . . . 875
Quint le Duc and
Quanming Shi and
Iris Blonk and
Arnoud Sonnenberg and
Ning Wang and
Deborah Leckband and
Johan de Rooij Vinculin potentiates E-cadherin
mechanosensing and is recruited to
actin-anchored sites within adherens
junctions in a myosin II-dependent
manner . . . . . . . . . . . . . . . . . 891
Ben Short Boi keeps Hedgehog close to home . . . . ??
Ben Short Rb gets ERK'd by the competition . . . . ??
Ben Short PIPs propel phagosomes . . . . . . . . . ??
Ben Short Setting the spindle's compass . . . . . 895
Caitlin Sedwick Ted Salmon: Kinetochores at the core of
it all . . . . . . . . . . . . . . . . . 896
David M. Gilbert Cell fate transitions and the
replication timing decision point . . . 899
Jaspreet S. Khurana and
William Theurkauf piRNAs, transposon silencing, and
\bionameDrosophila germline development 905
Nicholas D. Poulson and
Terry Lechler Robust control of mitotic spindle
orientation in the developing epidermis 915
Douglas R. Mackay and
Masaki Makise and
Katharine S. Ullman Defects in nuclear pore assembly lead to
activation of an Aurora B-mediated
abscission checkpoint . . . . . . . . . 923
Seok Min Jin and
Michael Lazarou and
Chunxin Wang and
Lesley A. Kane and
Derek P. Narendra and
Richard J. Youle Mitochondrial membrane potential
regulates PINK1 import and proteolytic
destabilization by PARL . . . . . . . . 933
Tiffiney R. Hartman and
Daniel Zinshteyn and
Heather K. Schofield and
Emmanuelle Nicolas and
Ami Okada and
Alana M. O'Reilly Drosophila Boi limits Hedgehog levels to
suppress follicle stem cell
proliferation . . . . . . . . . . . . . 943
Tovah A. Day and
Komariah Palle and
Laura R. Barkley and
Naoko Kakusho and
Ying Zou and
Satoshi Tateishi and
Alain Verreault and
Hisao Masai and
Cyrus Vaziri Phosphorylated Rad18 directs DNA
Polymerase $ \eta $ to sites of stalled
replication . . . . . . . . . . . . . . 953
Javier Rodríguez and
Fernando Calvo and
José M. González and
Berta Casar and
Vicente Andrés and
Piero Crespo ERK1\slash 2 MAP kinases promote cell
cycle entry by rapid, kinase-independent
disruption of retinoblastoma--lamin A
complexes . . . . . . . . . . . . . . . 967
Valentina Rossio and
Elena Galati and
Matteo Ferrari and
Achille Pellicioli and
Takashi Sutani and
Katsuhiko Shirahige and
Giovanna Lucchini and
Simonetta Piatti The RSC chromatin-remodeling complex
influences mitotic exit and adaptation
to the spindle assembly checkpoint by
controlling the Cdc14 phosphatase . . . 981
Michal Bohdanowicz and
Gabriela Cosío and
Jonathan M. Backer and
Sergio Grinstein Class I and class III phosphoinositide
$3$-kinases are required for actin
polymerization that propels phagosomes 999
Kristin L. Sens and
Shiliang Zhang and
Peng Jin and
Rui Duan and
Guofeng Zhang and
Fengbao Luo and
Lauren Parachini and
Elizabeth H. Chen An invasive podosome-like structure
promotes fusion pore formation during
myoblast fusion . . . . . . . . . . . . 1013
Sayantanee Biswas and
Michelle R. Emond and
James D. Jontes Protocadherin-19 and N-cadherin interact
to control cell movements during
anterior neurulation . . . . . . . . . . 1029
Mitch Leslie Ino80 tidies up after DNA repair . . . . ??
Mitch Leslie Mad2 shifts a motor into idle . . . . . ??
Mitch Leslie Doubling up on cellular stress . . . . . ??
Mitch Leslie Mitochondria help dynamins get a grip 1045
Caitlin Sedwick Liz Rhoades: Single molecules tell many
stories . . . . . . . . . . . . . . . . 1046
Daphne Selvaggia Cabianca and
Davide Gabellini FSHD: copy number variations on the
theme of muscular dystrophy . . . . . . 1049
Sovan Sarkar and
Rhian Kiely and
Peter J. McHugh The Ino80 chromatin-remodeling complex
restores chromatin structure during UV
DNA damage repair . . . . . . . . . . . 1061
Sang Hyun Lee and
Frank McCormick and
Hideyuki Saya Mad2 inhibits the mitotic kinesin MKlp2 1069
Micah T. Webster and
J. Michael McCaffery and
Orna Cohen-Fix Vesicle trafficking maintains nuclear
shape in \bionameSaccharomyces
cerevisiae during membrane proliferation 1079
Yuk-Kwan Choi and
Pengfei Liu and
Siu Kwan Sze and
Chao Dai and
Robert Z. Qi CDK5RAP2 stimulates microtubule
nucleation by the $ \gamma $-tubulin
ring complex . . . . . . . . . . . . . . 1089
Marco Geymonat and
Adonis Spanos and
Sanne Jensen and
Steven G. Sedgwick Phosphorylation of Lte1 by Cdk prevents
polarized growth during mitotic arrest
in S. cerevisiae . . . . . . . . . . . . 1097
Gang Li and
Christopher Scull and
Lale Ozcan and
Ira Tabas NADPH oxidase links endoplasmic
reticulum stress, oxidative stress, and
PKR activation to induce apoptosis . . . 1113
Sajjan Koirala and
Huyen T. Bui and
Heidi L. Schubert and
Debra M. Eckert and
Christopher P. Hill and
Michael S. Kay and
Janet M. Shaw Molecular architecture of a dynamin
adaptor: implications for assembly of
mitochondrial fission complexes . . . . 1127
Hidenori Otera and
Chunxin Wang and
Megan M. Cleland and
Kiyoko Setoguchi and
Sadaki Yokota and
Richard J. Youle and
Katsuyoshi Mihara Mff is an essential factor for
mitochondrial recruitment of Drp1 during
mitochondrial fission in mammalian cells 1141
Thomas Iskratsch and
Stephan Lange and
Joseph Dwyer and
Ay Lin Kho and
Cris dos Remedios and
Elisabeth Ehler Formin follows function: a
muscle-specific isoform of FHOD3 is
regulated by CK2 phosphorylation and
promotes myofibril maintenance . . . . . 1159
Cédric S. Asensio and
Daniel W. Sirkis and
Robert H. Edwards RNAi screen identifies a role for
adaptor protein AP-3 in sorting to the
regulated secretory pathway . . . . . . 1173
Eva Nievergall and
Peter W. Janes and
Carolin Stegmayer and
Mary E. Vail and
Fawaz G. Haj and
Shyh Wei Teng and
Benjamin G. Neel and
Philippe I. Bastiaens and
Martin Lackmann PTP1B regulates Eph receptor function
and trafficking . . . . . . . . . . . . 1189
Ronald S. Flannagan and
Rene E. Harrison and
Christopher M. Yip and
Khuloud Jaqaman and
Sergio Grinstein Dynamic macrophage ``probing'' is
required for the efficient capture of
phagocytic targets . . . . . . . . . . . 1205
Ben Short Zfp521 works its zinc fingers to the
bone . . . . . . . . . . . . . . . . . . ??
Ben Short Telomeres get SIRT-ified . . . . . . . . ??
Ben Short Myo1 provides a ring in the tail . . . . ??
Ben Short PP6 puts the brakes on spindle assembly 1221
Caitlin Sedwick Ramanujan Hegde: The prion puzzle and
protein translocation . . . . . . . . . 1222
Leo J. Pallanck Culling sick mitochondria from the herd 1225
Christine Salaun and
Jennifer Greaves and
Luke H. Chamberlain The intracellular dynamic of protein
palmitoylation . . . . . . . . . . . . . 1229
Rose Loughlin and
Rebecca Heald and
François Nédélec A computational model predicts
\bionameXenopus meiotic spindle
organization . . . . . . . . . . . . . . 1239
Manuel Breuer and
Agnieszka Kolano and
Mijung Kwon and
Chao-Chin Li and
Ting-Fen Tsai and
David Pellman and
Stéphane Brunet and
Marie-Hél\`ene Verlhac HURP permits MTOC sorting for robust
meiotic spindle bipolarity, similar to
extra centrosome clustering in cancer
cells . . . . . . . . . . . . . . . . . 1251
Naël Osmani and
Florent Peglion and
Philippe Chavrier and
Sandrine Etienne-Manneville Cdc42 localization and cell polarity
depend on membrane traffic . . . . . . . 1261
Eric Hesse and
Hiroaki Saito and
Riku Kiviranta and
Diego Correa and
Kei Yamana and
Lynn Neff and
Daniel Toben and
Georg Duda and
Azeddine Atfi and
Valérie Geoffroy and
William C. Horne and
Roland Baron Zfp521 controls bone mass by
HDAC3-dependent attenuation of Runx2
activity . . . . . . . . . . . . . . . . 1271
Xin Quan Ge and
J. Julian Blow Chk1 inhibits replication factory
activation but allows dormant origin
firing in existing factories . . . . . . 1285
Jose A. Palacios and
Daniel Herranz and
Maria Luigia De Bonis and
Susana Velasco and
Manuel Serrano and
Maria A. Blasco SIRT1 contributes to telomere
maintenance and augments global
homologous recombination . . . . . . . . 1299
Kang Zeng and
Ricardo Nunes Bastos and
Francis A. Barr and
Ulrike Gruneberg Protein phosphatase 6 regulates mitotic
spindle formation by controlling the
T-loop phosphorylation state of Aurora A
bound to its activator TPX2 . . . . . . 1315
Xiaodong Fang and
Jianying Luo and
Ryuichi Nishihama and
Carsten Wloka and
Christopher Dravis and
Mirko Travaglia and
Masayuki Iwase and
Elizabeth A. Vallen and
Erfei Bi Biphasic targeting and cleavage furrow
ingression directed by the tail of a
myosin II . . . . . . . . . . . . . . . 1333
Emilie Montembault and
Wei Zhang and
Marcin R. Przewloka and
Vincent Archambault and
Emeric W. Sevin and
Ernest D. Laue and
David M. Glover and
Pier Paolo D'Avino Nessun Dorma, a novel centralspindlin
partner, is required for cytokinesis in
\bionameDrosophila spermatocytes . . . . 1351
Atsushi Tanaka and
Megan M. Cleland and
Shan Xu and
Derek P. Narendra and
Der-Fen Suen and
Mariusz Karbowski and
Richard J. Youle Proteasome and p97 mediate mitophagy and
degradation of mitofusins induced by
Parkin . . . . . . . . . . . . . . . . . 1367
Allen P. Liu and
François Aguet and
Gaudenz Danuser and
Sandra L. Schmid Local clustering of transferrin
receptors promotes clathrin-coated pit
initiation . . . . . . . . . . . . . . . 1381
Pradyut K. Paul and
Sanjay K. Gupta and
Shephali Bhatnagar and
Siva K. Panguluri and
Bryant G. Darnay and
Yongwon Choi and
Ashok Kumar Targeted ablation of TRAF6 inhibits
skeletal muscle wasting in mice . . . . 1395
Martin Distel and
Jennifer C. Hocking and
Katrin Volkmann and
Reinhard W. Köster The centrosome neither persistently
leads migration nor determines the site
of axonogenesis in migrating neurons in
vivo . . . . . . . . . . . . . . . . . . 1413
Mitch Leslie Syndecan-3 gets the message . . . . . . ??
Mitch Leslie Cancer cells mothball mRNA after
microtubule collapse . . . . . . . . . . ??
Mitch Leslie Receptors flex to remove
neurotransmitter brake . . . . . . . . . ??
Mitch Leslie Two microscopes are better than one . . 3
Ben Short Sean Munro: Revealing the Golgi's true
identity . . . . . . . . . . . . . . . . 4
Christof Osman and
Dennis R. Voelker and
Thomas Langer Making heads or tails of phospholipids
in mitochondria . . . . . . . . . . . . 7
Eisuke Itakura and
Noboru Mizushima p62 targeting to the autophagosome
formation site requires
self-oligomerization but not LC3 binding 17
Marjorie A. Kuipers and
Timothy J. Stasevich and
Takayo Sasaki and
Korey A. Wilson and
Kristin L. Hazelwood and
James G. McNally and
Michael W. Davidson and
David M. Gilbert Highly stable loading of Mcm proteins
onto chromatin in living cells requires
replication to unload . . . . . . . . . 29
Stine Jòrgensen and
Morten Eskildsen and
Kasper Fugger and
Lisbeth Hansen and
Marie Sofie Yoo Larsen and
Arne Nedergaard Kousholt and
Randi G. Syljuåsen and
Morten Beck Trelle and
Ole Nòrregaard Jensen and
Kristian Helin and
Claus Storgaard Sòrensen SET8 is degraded via PCNA-coupled
CRL4(CDT2) ubiquitylation in S phase and
after UV irradiation . . . . . . . . . . 43
Sean M. Hartig and
Bin He and
Weiwen Long and
Benjamin M. Buehrer and
Michael A. Mancini Homeostatic levels of SRC-2 and SRC-3
promote early human adipogenesis . . . . 55
Yejing Ge and
Yuting Sun and
Jie Chen IGF-II is regulated by microRNA-125b in
skeletal myogenesis . . . . . . . . . . 69
Marisa Carbonaro and
Aurora O'Brate and
Paraskevi Giannakakou Microtubule disruption targets HIF-1$
\alpha $ mRNA to cytoplasmic P-bodies
for translational repression . . . . . . 83
Zhimin Wang and
Ceba Humphrey and
Nicole Frilot and
Gaofeng Wang and
Zhongzhen Nie and
Nader H. Moniri and
Yehia Daaka Dynamin2- and endothelial nitric oxide
synthase--regulated invasion of bladder
epithelial cells by uropathogenic
\bionameEscherichia coli . . . . . . . . 101
Wanda Kukulski and
Martin Schorb and
Sonja Welsch and
Andrea Picco and
Marko Kaksonen and
John A. G. Briggs Correlated fluorescence and $3$D
electron microscopy with high
sensitivity and spatial precision . . . 111
Ximing Du and
Jaspal Kumar and
Charles Ferguson and
Timothy A. Schulz and
Yan Shan Ong and
Wanjin Hong and
William A. Prinz and
Robert G. Parton and
Andrew J. Brown and
Hongyuan Yang A role for oxysterol-binding
protein--related protein 5 in endosomal
cholesterol trafficking . . . . . . . . 121
Yonatan M. Kupchik and
Ofra Barchad-Avitzur and
Jürgen Wess and
Yair Ben-Chaim and
Itzchak Parnas and
Hanna Parnas A novel fast mechanism for GPCR-mediated
signal transduction --- control of
neurotransmitter release . . . . . . . . 137
Maxim M. Bespalov and
Yulia A. Sidorova and
Sarka Tumova and
Anni Ahonen-Bishopp and
Ana Cathia Magalhães and
Evgeny Kulesskiy and
Mikhail Paveliev and
Claudio Rivera and
Heikki Rauvala and
Mart Saarma Heparan sulfate proteoglycan syndecan-3
is a novel receptor for GDNF, neurturin,
and artemin . . . . . . . . . . . . . . 153
Vinicio A. de Jesus Perez and
Ziad Ali and
Tero-Pekka Alastalo and
Fumiaki Ikeno and
Hirofumi Sawada and
Ying-Ju Lai and
Thomas Kleisli and
Edda Spiekerkoetter and
Xiumei Qu and
Laura H. Rubinos and
Euan Ashley and
Manuel Amieva and
Shoukat Dedhar and
Marlene Rabinovitch BMP promotes motility and represses
growth of smooth muscle cells by
activation of tandem Wnt pathways . . . 171
Alexandre Djiane and
Hideyuki Shimizu and
Marian Wilkin and
Sabine Mazleyrat and
Martin D. Jennings and
Johanna Avis and
Sarah Bray and
Martin Baron Su(dx) E3 ubiquitin ligase-dependent and
--independent functions of Polychaetoid,
the \bionameDrosophila ZO-1 homologue 189
Javier Rodríguez and
Fernando Calvo and
José M. González and
Berta Casar and
Vicente Andrés and
Piero Crespo ERK1\slash 2 MAP kinases promote cell
cycle entry by rapid, kinase-independent
disruption of retinoblastoma--lamin A
complexes . . . . . . . . . . . . . . . 201
Mitch Leslie ESCRT-III has an escort . . . . . . . . ??
Mitch Leslie Stiff ECM puts the brakes on microtubule
growth . . . . . . . . . . . . . . . . . ??
Mitch Leslie N-WASP allows axons to cover up . . . . ??
Mitch Leslie Helping the embryo find closure . . . . 205
Ben Short Matthew Welch: The many branches of
actin regulation . . . . . . . . . . . . 206
Patricia A. J. Muller and
Karen H. Vousden and
Jim C. Norman p53 and its mutants in tumor cell
migration and invasion . . . . . . . . . 209
Thomas Göhler and
Simone Sabbioneda and
Catherine M. Green and
Alan R. Lehmann ATR-mediated phosphorylation of DNA
polymerase $ \eta $ is needed for
efficient recovery from UV damage . . . 219
Daniel K. Stringer and
Robert C. Piper A single ubiquitin is sufficient for
cargo protein entry into MVBs in the
absence of ESCRT ubiquitination . . . . 229
Nurit Novak and
Vered Bar and
Helena Sabanay and
Shahar Frechter and
Martine Jaegle and
Scott B. Snapper and
Dies Meijer and
Elior Peles N-WASP is required for membrane wrapping
and myelination by Schwann cells . . . . 243
Hong Yan and
Thomas Toczylowski and
Jill McCane and
Chinyi Chen and
Shuren Liao Replication protein A promotes $ 5 ' \to
3 ' $ end processing during
homology-dependent DNA double-strand
break repair . . . . . . . . . . . . . . 251
Jibak Lee and
Tatsuya Hirano RAD21L, a novel cohesin subunit
implicated in linking homologous
chromosomes in mammalian meiosis . . . . 263
Benjamin Albert and
Isabelle Léger-Silvestre and
Christophe Normand and
Martin K. Ostermaier and
Jorge Pérez-Fernández and
Kostya I. Panov and
Joost C. B. M. Zomerdijk and
Patrick Schultz and
Olivier Gadal RNA polymerase I--specific subunits
promote polymerase clustering to enhance
the rRNA gene transcription cycle . . . 277
Megan Wemmer and
Ishara Azmi and
Matthew West and
Brian Davies and
David Katzmann and
Greg Odorizzi Bro1 binding to Snf7 regulates
ESCRT--III membrane scission activity in
yeast . . . . . . . . . . . . . . . . . 295
Meital Hatan and
Vera Shinder and
David Israeli and
Frank Schnorrer and
Talila Volk The \bionameDrosophila blood brain
barrier is maintained by GPCR-dependent
dynamic actin structures . . . . . . . . 307
Kenneth A. Myers and
Kathryn T. Applegate and
Gaudenz Danuser and
Robert S. Fischer and
Clare M. Waterman Distinct ECM mechanosensing pathways
regulate microtubule dynamics to control
endothelial cell branching morphogenesis 321
Caroline Laplante and
Laura A. Nilson Asymmetric distribution of Echinoid
defines the epidermal leading edge
during \bionameDrosophila dorsal closure 335
Shan Zhou and
Lihsia Chen Neural integrity is maintained by
dystrophin in \bionameC. elegans . . . . 349
Peisong Ma and
Shannon L. Beck and
Ronald W. Raab and
Robert L. McKown and
George L. Coffman and
Atsushi Utani and
William J. Chirico and
Alan C. Rapraeger and
Gordon W. Laurie Heparanase deglycanation of syndecan-1
is required for binding of the
epithelial-restricted prosecretory
mitogen lacritin . . . . . . . . . . . . 365
Ben Short Mutant phagosomes bite off more than
they can chew . . . . . . . . . . . . . ??
Ben Short Sir3 helps telomeres stick together . . ??
Ben Short IRSp53 keeps ECM signaling up to Par . . ??
Ben Short BRCA1 on the move . . . . . . . . . . . 369
Caitlin Sedwick María Blasco: Keeping a cap on cancer and
aging . . . . . . . . . . . . . . . . . 370
Min Yu and
Shannon Stott and
Mehmet Toner and
Shyamala Maheswaran and
Daniel A. Haber Circulating tumor cells: approaches to
isolation and characterization . . . . . 373
Mohammed Ali Akbar and
Charles Tracy and
Walter H. A. Kahr and
Helmut Krämer The full-of-bacteria gene is required
for phagosome maturation during immune
defense in \bionameDrosophila . . . . . 383
Pauline G. Knox and
Clare C. Davies and
Marina Ioannou and
Aristides G. Eliopoulos The death domain kinase RIP1 links the
immunoregulatory CD40 receptor to
apoptotic signaling in carcinomas . . . 391
René M. Overmeer and
Jill Moser and
Marcel Volker and
Hanneke Kool and
Alan E. Tomkinson and
Albert A. van Zeeland and
Leon H. F. Mullenders and
Maria Fousteri Replication protein A safeguards genome
integrity by controlling NER incision
events . . . . . . . . . . . . . . . . . 401
Myriam Ruault and
Arnaud De Meyer and
Isabelle Lo\"\iodice and
Angela Taddei Clustering heterochromatin: Sir3
promotes telomere clustering
independently of silencing in yeast . . 417
Eliza \.Zy\lkiewicz and
Monika Kija\'nska and
Won-Chan Choi and
Urszula Derewenda and
Zygmunt S. Derewenda and
P. Todd Stukenberg The N-terminal coiled-coil of Ndel1 is a
regulated scaffold that recruits LIS1 to
dynein . . . . . . . . . . . . . . . . . 433
Steven M. Claypool and
Kevin Whited and
Santi Srijumnong and
Xianlin Han and
Carla M. Koehler Barth syndrome mutations that cause
tafazzin complex lability . . . . . . . 447
Rinshi S. Kasai and
Kenichi G. N. Suzuki and
Eric R. Prossnitz and
Ikuko Koyama-Honda and
Chieko Nakada and
Takahiro K. Fujiwara and
Akihiro Kusumi Full characterization of GPCR
monomer--dimer dynamic equilibrium by
single molecule imaging . . . . . . . . 463
Anindya Sen and
Takakazu Yokokura and
Mark W. Kankel and
Douglas N. Dimlich and
Jan Manent and
Subhabrata Sanyal and
Spyros Artavanis-Tsakonas Modeling spinal muscular atrophy in
\bionameDrosophila links Smn to FGF
signaling . . . . . . . . . . . . . . . 481
Elisabeth D. Coene and
Catarina Gadelha and
Nicholas White and
Ashraf Malhas and
Benjamin Thomas and
Michael Shaw and
David J. Vaux A novel role for BRCA1 in regulating
breast cancer cell spreading and
motility . . . . . . . . . . . . . . . . 497
Minna Poukkula and
Adam Cliffe and
Rishita Changede and
Pernille Ròrth Cell behaviors regulated by guidance
cues in collective migration of border
cells . . . . . . . . . . . . . . . . . 513
David Cohen and
Dawn Fernandez and
Francisco Lázaro-Diéguez and
Anne Müsch The serine/threonine kinase Par1b
regulates epithelial lumen polarity via
IRSp53-mediated cell--ECM signaling . . 525
Mitch Leslie Sphingolipid imbalance can take out an
eye . . . . . . . . . . . . . . . . . . ??
Mitch Leslie Annexin keeps tau on a short leash . . . ??
Mitch Leslie Natural killer cells commute death
sentence . . . . . . . . . . . . . . . . ??
Mitch Leslie Hedgehog, meet Patched . . . . . . . . . 543
Caitlin Sedwick Harald Stenmark: Hands on FYVE-fingers 544
Francis Rodier and
Judith Campisi Four faces of cellular senescence . . . 547
Ikuko Yonamine and
Takeshi Bamba and
Niraj K. Nirala and
Nahid Jesmin and
Teresa Kosakowska-Cholody and
Kunio Nagashima and
Eiichiro Fukusaki and
Jairaj K. Acharya and
Usha Acharya Sphingosine kinases and their
metabolites modulate endolysosomal
trafficking in photoreceptors . . . . . 557
Rafael Bernad and
Patricia Sánchez and
Teresa Rivera and
Miriam Rodríguez-Corsino and
Ekaterina Boyarchuk and
Isabelle Vassias and
Dominique Ray-Gallet and
Alexei Arnaoutov and
Mary Dasso and
Genevi\`eve Almouzni and
Ana Losada Xenopus HJURP and condensin II are
required for CENP--A assembly . . . . . 569
Cornelia Kurischko and
Hong Kyung Kim and
Venkata K. Kuravi and
Juliane Pratzka and
Francis C. Luca The yeast Cbk1 kinase regulates mRNA
localization via the mRNA-binding
protein Ssd1 . . . . . . . . . . . . . . 583
Mauricio Valerio-Santiago and
Fernando Monje-Casas Tem1 localization to the spindle pole
bodies is essential for mitotic exit and
impairs spindle checkpoint function . . 599
Eugenia Morselli and
Guillermo Mariño and
Martin V. Bennetzen and
Tobias Eisenberg and
Evgenia Megalou and
Sabrina Schroeder and
Sandra Cabrera and
Paule Bénit and
Pierre Rustin and
Alfredo Criollo and
Oliver Kepp and
Lorenzo Galluzzi and
Shensi Shen and
Shoaib Ahmad Malik and
Maria Chiara Maiuri and
Yoshiyuki Horio and
Carlos López-Otín and
Jens S. Andersen and
Nektarios Tavernarakis and
Frank Madeo and
Guido Kroemer Spermidine and resveratrol induce
autophagy by distinct pathways
converging on the acetylproteome . . . . 615
Helen Hoffmeister and
Karin Babinger and
Sonja Gürster and
Anna Cedzich and
Christine Meese and
Karin Schadendorf and
Larissa Osten and
Uwe de Vries and
Anne Rascle and
Ralph Witzgall Polycystin-2 takes different routes to
the somatic and ciliary plasma membrane 631
Anne Gauthier-Kemper and
Carina Weissmann and
Nataliya Golovyashkina and
Zsofia Sebö-Lemke and
Gerard Drewes and
Volker Gerke and
Jürgen J. Heinisch and
Roland Brandt The frontotemporal dementia mutation
R406W blocks tau's interaction with the
membrane in an annexin A2-dependent
manner . . . . . . . . . . . . . . . . . 647
Andy Tsun and
Ihjaaz Qureshi and
Jane C. Stinchcombe and
Misty R. Jenkins and
Maike de la Roche and
Joanna Kleczkowska and
Rose Zamoyska and
Gillian M. Griffiths Centrosome docking at the immunological
synapse is controlled by Lck signaling 663
Thushara P. Abeyweera and
Ernesto Merino and
Morgan Huse Inhibitory signaling blocks activating
receptor clustering and induces
cytoskeletal retraction in natural
killer cells . . . . . . . . . . . . . . 675
Fuchuan Li and
Wen Shi and
Mariana Capurro and
Jorge Filmus Glypican-5 stimulates rhabdomyosarcoma
cell proliferation by activating
Hedgehog signaling . . . . . . . . . . . 691
Ben Short Rad54 mutant stays rooted to the spot ??
Ben Short A fifth amendment to the intestine's
constitution . . . . . . . . . . . . . . ??
Ben Short The Tudor family produces heirs . . . . ??
Ben Short The wrong suspect? . . . . . . . . . . . 707
Caitlin Sedwick Joan Steitz: RNA is a many-splendored
thing . . . . . . . . . . . . . . . . . 708
Indika Rajapakse and
Mark Groudine On emerging nuclear order . . . . . . . 711
Christophe Zimmer and
Emmanuelle Fabre Principles of chromosomal organization:
lessons from yeast . . . . . . . . . . . 723
Sheba Agarwal and
Wiggert A. van Cappellen and
Aude Guénolé and
Berina Eppink and
Sam E. V. Linsen and
Erik Meijering and
Adriaan Houtsmuller and
Roland Kanaar and
Jeroen Essers ATP-dependent and independent functions
of Rad54 in genome maintenance . . . . . 735
Antoine Bondue and
Simon Tännler and
Giuseppe Chiapparo and
Samira Chabab and
Mirana Ramialison and
Catherine Paulissen and
Benjamin Beck and
Richard Harvey and
Cédric Blanpain Defining the earliest step of
cardiovascular progenitor specification
during embryonic stem cell
differentiation . . . . . . . . . . . . 751
François Gerbe and
Johan H. van Es and
Leila Makrini and
Bénédicte Brulin and
Georg Mellitzer and
Sylvie Robine and
Béatrice Romagnolo and
Noah F. Shroyer and
Jean-François Bourgaux and
Christine Pignodel and
Hans Clevers and
Philippe Jay Distinct ATOH1 and Neurog3 requirements
define tuft cells as a new secretory
cell type in the intestinal epithelium 767
Yukihiro Yabuta and
Hiroshi Ohta and
Takaya Abe and
Kazuki Kurimoto and
Shinichiro Chuma and
Mitinori Saitou TDRD5 is required for retrotransposon
silencing, chromatoid body assembly, and
spermiogenesis in mice . . . . . . . . . 781
Lisbeth S. Laursen and
Colin W. Chan and
Charles ffrench-Constant Translation of myelin basic protein mRNA
in oligodendrocytes is regulated by
integrin activation and hnRNP--K . . . . 797
Hél\`ene Vacher and
Jae-Won Yang and
Oscar Cerda and
Amapola Autillo-Touati and
Bénédicte Dargent and
James S. Trimmer Cdk-mediated phosphorylation of the Kv$
\beta $2 auxiliary subunit regulates Kv1
channel axonal targeting . . . . . . . . 813
Xin Chen and
Hanna Tukachinsky and
Chih-Hsiang Huang and
Cindy Jao and
Yue-Ru Chu and
Hsiang-Yun Tang and
Britta Mueller and
Sol Schulman and
Tom A. Rapoport and
Adrian Salic Processing and turnover of the Hedgehog
protein in the endoplasmic reticulum . . 825
Takashi Itoh and
Eiko Kanno and
Takefumi Uemura and
Satoshi Waguri and
Mitsunori Fukuda OATL1, a novel autophagosome-resident
Rab33B--GAP, regulates autophagosomal
maturation . . . . . . . . . . . . . . . 839
Stéphanie Bolhy and
Im\`ene Bouhlel and
Elisa Dultz and
Tania Nayak and
Michela Zuccolo and
Xavier Gatti and
Richard Vallee and
Jan Ellenberg and
Valérie Doye A Nup133-dependent NPC-anchored network
tethers centrosomes to the nuclear
envelope in prophase . . . . . . . . . . 855
Won-Seok Choi and
Richard D. Palmiter and
Zhengui Xia Loss of mitochondrial complex I activity
potentiates dopamine neuron death
induced by microtubule dysfunction in a
Parkinson's disease model . . . . . . . 873
Sarah Schmidt and
Inaam Nakchbandi and
Raphael Ruppert and
Nina Kawelke and
Michael W. Hess and
Kristian Pfaller and
Pierre Jurdic and
Reinhard Fässler and
Markus Moser Kindlin-3-mediated signaling from
multiple integrin classes is required
for osteoclast-mediated bone resorption 883
Rafael Bernad and
Patricia Sánchez and
Teresa Rivera and
Miriam Rodríguez-Corsino and
Ekaterina Boyarchuk and
Isabelle Vassias and
Dominique Ray-Gallet and
Alexei Arnaoutov and
Mary Dasso and
Genevi\`eve Almouzni and
Ana Losada Xenopus HJURP and condensin II are
required for CENP--A assembly . . . . . 899
Ben Short Location is everything . . . . . . . . . ??
Ben Short Connecting the cytokinesis dots . . . . ??
Ben Short Osteoblasts are bone idle without
Frizzled-9 . . . . . . . . . . . . . . . ??
Ben Short Cadherins trade bonds . . . . . . . . . 903
Caitlin Sedwick Pascale Cossart: The ins and outs of
\bionameListeria . . . . . . . . . . . . 904
Buzz Baum and
Marios Georgiou Dynamics of adherens junctions in
epithelial establishment, maintenance,
and remodeling . . . . . . . . . . . . . 907
Shannon Behrman and
Diego Acosta-Alvear and
Peter Walter A CHOP-regulated microRNA controls
rhodopsin expression . . . . . . . . . . 919
Momoyo Hanazawa and
Masafumi Yonetani and
Asako Sugimoto PGL proteins self associate and bind
RNPs to mediate germ granule assembly in
\bionameC. elegans . . . . . . . . . . . 929
Dustin L. Updike and
Stephanie J. Hachey and
Jeremy Kreher and
Susan Strome P granules extend the nuclear pore
complex environment in the \bionameC.
elegans germ line . . . . . . . . . . . 939
Damien Laporte and
Anne Lebaudy and
Annelise Sahin and
Beno\^\it Pinson and
Johanna Ceschin and
Bertrand Daignan-Fornier and
Isabelle Sagot Metabolic status rather than cell cycle
signals control quiescence entry and
exit . . . . . . . . . . . . . . . . . . 949
Anja K. Dunsch and
Emily Linnane and
Francis A. Barr and
Ulrike Gruneberg The astrin--kinastrin/SKAP complex
localizes to microtubule plus ends and
facilitates chromosome alignment . . . . 959
Juan A. Bernal and
Ashok R. Venkitaraman A vertebrate N-end rule degron reveals
that Orc6 is required in mitosis for
daughter cell abscission . . . . . . . . 969
Bill X. Huang and
Mohammed Akbar and
Karl Kevala and
Hee-Yong Kim Phosphatidylserine is a critical
modulator for Akt activation . . . . . . 979
Yoshimi Endo Greer and
Jeffrey S. Rubin Casein kinase 1 delta functions at the
centrosome to mediate Wnt-3a-dependent
neurite outgrowth . . . . . . . . . . . 993
Damien Laporte and
Valerie C. Coffman and
I-Ju Lee and
Jian-Qiu Wu Assembly and architecture of precursor
nodes during fission yeast cytokinesis 1005
Corey L. Williams and
Chunmei Li and
Katarzyna Kida and
Peter N. Inglis and
Swetha Mohan and
Lucie Semenec and
Nathan J. Bialas and
Rachel M. Stupay and
Nansheng Chen and
Oliver E. Blacque and
Bradley K. Yoder and
Michel R. Leroux MKS and NPHP modules cooperate to
establish basal body/transition zone
membrane associations and ciliary gate
function during ciliogenesis . . . . . . 1023
Oludotun Adeyo and
Patrick J. Horn and
SungKyung Lee and
Derk D. Binns and
Anita Chandrahas and
Kent D. Chapman and
Joel M. Goodman The yeast lipin orthologue Pah1p is
important for biogenesis of lipid
droplets . . . . . . . . . . . . . . . . 1043
Joachim Albers and
Jochen Schulze and
F. Timo Beil and
Matthias Gebauer and
Anke Baranowsky and
Johannes Keller and
Robert P. Marshall and
Kristofer Wintges and
Felix W. Friedrich and
Matthias Priemel and
Arndt F. Schilling and
Johannes M. Rueger and
Kerstin Cornils and
Boris Fehse and
Thomas Streichert and
Guido Sauter and
Franz Jakob and
Karl L. Insogna and
Barbara Pober and
Klaus-Peter Knobeloch and
Uta Francke and
Michael Amling and
Thorsten Schinke Control of bone formation by the
serpentine receptor Frizzled-9 . . . . . 1057
Soonjin Hong and
Regina B. Troyanovsky and
Sergey M. Troyanovsky Cadherin exits the junction by switching
its adhesive bond . . . . . . . . . . . 1073
Mitch Leslie Paraspeckles may provide stress relief ??
Mitch Leslie Multiple routes to the inner nuclear
membrane . . . . . . . . . . . . . . . . ??
Mitch Leslie Wnt sends mixed signals in the skin . . ??
Mitch Leslie Kinetochores feel the pull . . . . . . . 3
Caitlin Sedwick Peter Walter: Investigating how the ER
handles secretory proteins . . . . . . . 4
Changle Ma and
Gaurav Agrawal and
Suresh Subramani Peroxisome assembly: matrix and membrane
protein biogenesis . . . . . . . . . . . 7
Frank Sicheri and
Robert H. Silverman Putting the brakes on the unfolded
protein response . . . . . . . . . . . . 17
Izhak Kehat and
Federica Accornero and
Bruce J. Aronow and
Jeffery D. Molkentin Modulation of chromatin position and
gene expression by HDAC4 interaction
with nucleoporins . . . . . . . . . . . 21
Shinichi Nakagawa and
Takao Naganuma and
Go Shioi and
Tetsuro Hirose Paraspeckles are subpopulation-specific
nuclear bodies that are not essential in
mice . . . . . . . . . . . . . . . . . . 31
Aditi Chawla and
Sutapa Chakrabarti and
Gourisankar Ghosh and
Maho Niwa Attenuation of yeast UPR is essential
for survival and is mediated by IRE1
kinase . . . . . . . . . . . . . . . . . 41
Richard S. Kang and
Heike Fölsch ARH cooperates with AP-1B in the
exocytosis of LDLR in polarized
epithelial cells . . . . . . . . . . . . 51
Zhizhan Gu and
Erika H. Noss and
Victor W. Hsu and
Michael B. Brenner Integrins traffic rapidly via circular
dorsal ruffles and macropinocytosis
during stimulated cell migration . . . . 61
Tobias Morawe and
Mona Honemann-Capito and
Walter von Stein and
Andreas Wodarz Loss of the extraproteasomal ubiquitin
receptor Rings lost impairs ring canal
growth in \bionameDrosophila oogenesis 71
Céline Baldeyron and
Gaston Soria and
Dani\`ele Roche and
Adam J. L. Cook and
Genevi\`eve Almouzni HP1$ \alpha $ recruitment to DNA damage
by p150CAF-1 promotes homologous
recombination repair . . . . . . . . . . 81
Jeanine A. Harrigan and
Rimma Belotserkovskaya and
Julia Coates and
Daniela S. Dimitrova and
Sophie E. Polo and
Charles R. Bradshaw and
Peter Fraser and
Stephen P. Jackson Replication stress induces
53BP1-containing OPT domains in G1 cells 97
Nikolaj Zuleger and
David A. Kelly and
A. Christine Richardson and
Alastair R. W. Kerr and
Martin W. Goldberg and
Andrew B. Goryachev and
Eric C. Schirmer System analysis shows distinct
mechanisms and common principles of
nuclear envelope protein dynamics . . . 109
Aussie Suzuki and
Tetsuya Hori and
Tatsuya Nishino and
Jiro Usukura and
Atsushi Miyagi and
Kosuke Morikawa and
Tatsuo Fukagawa Spindle microtubules generate
tension-dependent changes in the
distribution of inner kinetochore
proteins . . . . . . . . . . . . . . . . 125
Elise Peyre and
Florence Jaouen and
Mehdi Saadaoui and
Laurence Haren and
Andreas Merdes and
Pascale Durbec and
Xavier Morin A lateral belt of cortical LGN and NuMA
guides mitotic spindle movements and
planar division in neuroepithelial cells 141
Lindsay Lewellyn and
Ana Carvalho and
Arshad Desai and
Amy S. Maddox and
Karen Oegema The chromosomal passenger complex and
centralspindlin independently contribute
to contractile ring assembly . . . . . . 155
Claudia Rubio and
David Pincus and
Alexei Korennykh and
Sebastian Schuck and
Hana El-Samad and
Peter Walter Homeostatic adaptation to endoplasmic
reticulum stress depends on Ire1 kinase
activity . . . . . . . . . . . . . . . . 171
Jenna L. Jewell and
Eunjin Oh and
Latha Ramalingam and
Michael A. Kalwat and
Vincent S. Tagliabracci and
Lixuan Tackett and
Jeffrey S. Elmendorf and
Debbie C. Thurmond Munc18c phosphorylation by the insulin
receptor links cell signaling directly
to SNARE exocytosis . . . . . . . . . . 185
Avital A. Rodal and
Aline D. Blunk and
Yulia Akbergenova and
Ramon A. Jorquera and
Lauren K. Buhl and
J. Troy Littleton A presynaptic endosomal trafficking
pathway controls synaptic growth
signaling . . . . . . . . . . . . . . . 201
Stephen S. Francis and
Jeff Sfakianos and
Bryan Lo and
Ira Mellman A hierarchy of signals regulates entry
of membrane proteins into the ciliary
membrane domain in epithelial cells . . 219
Karen M. Osorio and
Karin C. Lilja and
Tudorita Tumbar Runx1 modulates adult hair follicle stem
cell emergence and maintenance from
distinct embryonic skin compartments . . 235
Ben Short Passengers operate the brakes . . . . . ??
Ben Short How the ER shapes up and ships out . . . ??
Ben Short Myosin II gets polarity back to front ??
Ben Short Repair defects put stem cells in a fix 253
Ben Short Angelika Amon: Conquering the divide . . 254
Ling Liu and
Thomas A. Rando Manifestations and mechanisms of stem
cell aging . . . . . . . . . . . . . . . 257
Jiadong Wang and
Zihua Gong and
Junjie Chen MDC1 collaborates with TopBP1 in DNA
replication checkpoint control . . . . . 267
Yoshihiro Inami and
Satoshi Waguri and
Ayako Sakamoto and
Tsuguka Kouno and
Kazuto Nakada and
Okio Hino and
Sumio Watanabe and
Jin Ando and
Manabu Iwadate and
Masayuki Yamamoto and
Myung-Shik Lee and
Keiji Tanaka and
Masaaki Komatsu Persistent activation of Nrf2 through
p62 in hepatocellular carcinoma cells 275
Daniel K. Rozelle and
Scott D. Hansen and
Kenneth B. Kaplan Chromosome passenger complexes control
anaphase duration and spindle elongation
via a kinesin-5 brake . . . . . . . . . 285
Shichuan Zhang and
Hirohiko Yajima and
HoangDinh Huynh and
Junke Zheng and
Elsa Callen and
Hua-Tang Chen and
Nancy Wong and
Samuel Bunting and
Yu-Fen Lin and
Mengxia Li and
Kyung-Jone Lee and
Michael Story and
Eric Gapud and
Barry P. Sleckman and
André Nussenzweig and
Cheng Cheng Zhang and
David J. Chen and
Benjamin P. C. Chen Congenital bone marrow failure in
DNA--PKcs mutant mice associated with
deficiencies in DNA repair . . . . . . . 295
Tiago J. Dantas and
Yifan Wang and
Pierce Lalor and
Peter Dockery and
Ciaran G. Morrison Defective nucleotide excision repair
with normal centrosome structures and
functions in the absence of all
vertebrate centrins . . . . . . . . . . 307
Tomoki Yano and
Yuji Yamazaki and
Makoto Adachi and
Katsuya Okawa and
Philippe Fort and
Masami Uji and
Shoichiro Tsukita and
Sachiko Tsukita Tara up-regulates E-cadherin
transcription by binding to the Trio
RhoGEF and inhibiting Rac signaling . . 319
Matt West and
Nesia Zurek and
Andreas Hoenger and
Gia K. Voeltz A $3$D analysis of yeast ER structure
reveals how ER domains are organized by
membrane curvature . . . . . . . . . . . 333
Michele E. Day and
Guido M. Gaietta and
Mira Sastri and
Antonius Koller and
Mason R. Mackey and
John D. Scott and
Guy A. Perkins and
Mark H. Ellisman and
Susan S. Taylor Isoform-specific targeting of PKA to
multivesicular bodies . . . . . . . . . 347
Tai Kiuchi and
Tomoaki Nagai and
Kazumasa Ohashi and
Kensaku Mizuno Measurements of spatiotemporal changes
in G-actin concentration reveal its
effect on stimulus-induced actin
assembly and lamellipodium extension . . 365
Miguel Vicente-Manzanares and
Karen Newell-Litwa and
Alexia I. Bachir and
Leanna A. Whitmore and
Alan Rick Horwitz Myosin IIA/IIB restrict adhesive and
protrusive signaling to generate
front--back polarity in migrating cells 381
Céline Caillava and
Renaud Vandenbosch and
Beata Jablonska and
Cyrille Deboux and
Giulia Spigoni and
Vittorio Gallo and
Brigitte Malgrange and
Anne Baron-Van Evercooren Cdk2 loss accelerates precursor
differentiation and remyelination in the
adult central nervous system . . . . . . 397
Dan Xu and
Fumitaka Takeshita and
Yumiko Hino and
Saori Fukunaga and
Yasusei Kudo and
Aya Tamaki and
Junko Matsunaga and
Ryou-u Takahashi and
Takashi Takata and
Akira Shimamoto and
Takahiro Ochiya and
Hidetoshi Tahara miR-22 represses cancer progression by
inducing cellular senescence . . . . . . 409
Mitch Leslie Proteins keep Cdc55 in its place . . . . ??
Mitch Leslie A histone finds a traveling companion ??
Mitch Leslie Plant virus gets the bends . . . . . . . ??
Mitch Leslie PAR proteins cross the boundary . . . . 427
Caitlin Sedwick Erik Sahai: Getting the whole picture of
metastasis . . . . . . . . . . . . . . . 428
Hans A. Kestler and
Michael Kühl Generating a Wnt switch: it's all about
the right dosage . . . . . . . . . . . . 431
Tetsuo Kobayashi and
Brian D. Dynlacht Regulating the transition from centriole
to basal body . . . . . . . . . . . . . 435
Valentina Rossio and
Satoshi Yoshida Spatial regulation of Cdc55--PP2A by
Zds1/Zds2 controls mitotic entry and
mitotic exit in budding yeast . . . . . 445
Maria Teresa Abreu-Blanco and
Jeffrey M. Verboon and
Susan M. Parkhurst Cell wound repair in \bionameDrosophila
occurs through three distinct phases of
membrane and cytoskeletal remodeling . . 455
Peter J. Cavnar and
Erwin Berthier and
David J. Beebe and
Anna Huttenlocher Hax1 regulates neutrophil adhesion and
motility through RhoA . . . . . . . . . 465
He Zhang and
Beibei Niu and
Ji-Fan Hu and
Shengfang Ge and
Haibo Wang and
Tao Li and
Jianqun Ling and
Brandon N. Steelman and
Guanxiang Qian and
Andrew R. Hoffman Interruption of intrachromosomal looping
by CCCTC binding factor decoy proteins
abrogates genomic imprinting of human
insulin-like growth factor II . . . . . 475
Jennifer M. Gardner and
Christine J. Smoyer and
Elizabeth S. Stensrud and
Richard Alexander and
Madelaine Gogol and
Winfried Wiegraebe and
Sue L. Jaspersen Targeting of the SUN protein Mps3 to the
inner nuclear membrane by the histone
variant H2A.Z . . . . . . . . . . . . . 489
Jung-Chun Lin and
Woan-Yuh Tarn RBM4 down-regulates PTB and antagonizes
its activity in muscle cell--specific
alternative splicing . . . . . . . . . . 509
Chih-Hang Wu and
Shu-Chuan Lee and
Chao-Wen Wang Viral protein targeting to the cortical
endoplasmic reticulum is required for
cell--cell spreading in plants . . . . . 521
Ilaria Prada and
Julie Marchaland and
Paola Podini and
Lorenzo Magrassi and
Rosalba D'Alessandro and
Paola Bezzi and
Jacopo Meldolesi REST\slash NRSF governs the expression
of dense-core vesicle gliosecretion in
astrocytes . . . . . . . . . . . . . . . 537
Giovanna Nalesso and
Joanna Sherwood and
Jessica Bertrand and
Thomas Pap and
Manoj Ramachandran and
Cosimo De Bari and
Costantino Pitzalis and
Francesco Dell'Accio WNT-3A modulates articular chondrocyte
phenotype by activating both canonical
and noncanonical pathways . . . . . . . 551
David R. Raleigh and
Devin M. Boe and
Dan Yu and
Christopher R. Weber and
Amanda M. Marchiando and
Emily M. Bradford and
Yingmin Wang and
Licheng Wu and
Eveline E. Schneeberger and
Le Shen and
Jerrold R. Turner Occludin S408 phosphorylation regulates
tight junction protein interactions and
barrier function . . . . . . . . . . . . 565
Nathan W. Goehring and
Carsten Hoege and
Stephan W. Grill and
Anthony A. Hyman PAR proteins diffuse freely across the
anterior--posterior boundary in
polarized \bionameC. elegans embryos . . 583
Ben Short HIV-1 makes a pore adjustment . . . . . ??
Ben Short Sphingolipid puts the squeeze on
apoptotic cells . . . . . . . . . . . . ??
Ben Short Bigger isn't better . . . . . . . . . . ??
Ben Short Titin isn't a sleeping giant . . . . . . 597
Ben Short Harvey McMahon: Ahead of the curve on
membrane dynamics . . . . . . . . . . . 598
Michael S. Brown and
Joseph L. Goldstein Richard G.W. Anderson (1940--2011) and
the birth of receptor-mediated
endocytosis . . . . . . . . . . . . . . 601
Miroslav Dundr Seed and grow: a two-step model for
nuclear body biogenesis . . . . . . . . 605
Stefan Schulte-Merker and
Amélie Sabine and
Tatiana V. Petrova Lymphatic vascular morphogenesis in
development, physiology, and disease . . 607
Anne Monette and
Nelly Panté and
Andrew J. Mouland HIV-1 remodels the nuclear pore complex 619
Sandra Habbig and
Malte P. Bartram and
Roman U. Müller and
Ricarda Schwarz and
Nikolaos Andriopoulos and
Shuhua Chen and
Josef G. Sägmüller and
Martin Hoehne and
Volker Burst and
Max C. Liebau and
H. Christian Reinhardt and
Thomas Benzing and
Bernhard Schermer NPHP4, a cilia-associated protein,
negatively regulates the Hippo pathway 633
Yingke Xu and
Bradley R. Rubin and
Charisse M. Orme and
Alexander Karpikov and
Chenfei Yu and
Jonathan S. Bogan and
Derek K. Toomre Dual-mode of insulin action controls
GLUT4 vesicle exocytosis . . . . . . . . 643
Francisco M. Vega and
Gilbert Fruhwirth and
Tony Ng and
Anne J. Ridley RhoA and RhoC have distinct roles in
migration and invasion by acting through
different targets . . . . . . . . . . . 655
Yapeng Gu and
Tetyana Forostyan and
Roger Sabbadini and
Jody Rosenblatt Epithelial cell extrusion requires the
sphingosine-$1$-phosphate receptor 2
pathway . . . . . . . . . . . . . . . . 667
Anne E. White and
Brandon D. Burch and
Xiao-cui Yang and
Pamela Y. Gasdaska and
Zbigniew Dominski and
William F. Marzluff and
Robert J. Duronio Drosophila histone locus bodies form by
hierarchical recruitment of components 677
Alla Amcheslavsky and
Naoto Ito and
Jin Jiang and
Y. Tony Ip Tuberous sclerosis complex and Myc
coordinate the growth and division of
\bionameDrosophila intestinal stem cells 695
Radhika Gudi and
Chaozhong Zou and
Jun Li and
Qingshen Gao Centrobin--tubulin interaction is
required for centriole elongation and
stability . . . . . . . . . . . . . . . 711
Won-Jing Wang and
Rajesh Kumar Soni and
Kunihiro Uryu and
Meng-Fu Bryan Tsou The conversion of centrioles to
centrosomes: essential coupling of
duplication with segregation . . . . . . 727
Telsa M. Mittelmeier and
Joseph S. Boyd and
Mary Rose Lamb and
Carol L. Dieckmann Asymmetric properties of the
Chlamydomonas reinhardtii cytoskeleton
direct rhodopsin photoreceptor
localization . . . . . . . . . . . . . . 741
Kai Mao and
Ke Wang and
Mantong Zhao and
Tao Xu and
Daniel J. Klionsky Two MAPK-signaling pathways are required
for mitophagy in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 755
Chiung-Ya Chen and
Chia-Wen Lin and
Chiung-Ying Chang and
Si-Tse Jiang and
Yi-Ping Hsueh Sarm1, a negative regulator of innate
immunity, interacts with syndecan-2 and
regulates neuronal morphology . . . . . 769
Katharina da Silva Lopes and
Agnieszka Pietas and
Michael H. Radke and
Michael Gotthardt Titin visualization in real time reveals
an unexpected level of mobility within
and between sarcomeres . . . . . . . . . 785
Mitch Leslie WASH cleans up after sloppy eaters . . . ??
Mitch Leslie Caveolin-1 says NO to permeability . . . ??
Mitch Leslie Noncoding RNA to blame for bad editing ??
Mitch Leslie One collagen shipment, ready for
delivery . . . . . . . . . . . . . . . . 801
Caitlin Sedwick Valerie Weaver: Overcoming cancer's
stiff resistance . . . . . . . . . . . . 802
Wakako Takabe and
Noah Alberts-Grill and
Hanjoong Jo Disturbed flow: p53 SUMOylation in the
turnover of endothelial cells . . . . . 805
Chan Bae Park and
Nils-Göran Larsson Mitochondrial DNA mutations in disease
and aging . . . . . . . . . . . . . . . 809
Ute Schmidt and
Eugenia Basyuk and
Marie-Cécile Robert and
Minoru Yoshida and
Jean-Philippe Villemin and
Didier Auboeuf and
Stuart Aitken and
Edouard Bertrand Real-time imaging of cotranscriptional
splicing reveals a kinetic model that
reduces noise: implications for
alternative splicing regulation . . . . 819
Michael Carnell and
Tobias Zech and
Simon D. Calaminus and
Seiji Ura and
Monica Hagedorn and
Simon A. Johnston and
Robin C. May and
Thierry Soldati and
Laura M. Machesky and
Robert H. Insall Actin polymerization driven by WASH
causes V--ATPase retrieval and vesicle
neutralization before exocytosis . . . . 831
M. Rizwan Siddiqui and
Yulia A. Komarova and
Stephen M. Vogel and
Xiaopei Gao and
Marcelo G. Bonini and
Johnson Rajasingh and
You-Yang Zhao and
Viktor Brovkovych and
Asrar B. Malik Caveolin-1-eNOS signaling promotes
p190RhoGAP--A nitration and endothelial
permeability . . . . . . . . . . . . . . 841
Sara Massone and
Irene Vassallo and
Manuele Castelnuovo and
Gloria Fiorino and
Elena Gatta and
Mauro Robello and
Roberta Borghi and
Massimo Tabaton and
Claudio Russo and
Giorgio Dieci and
Ranieri Cancedda and
Aldo Pagano RNA polymerase III drives alternative
splicing of the potassium
channel--interacting protein
contributing to brain complexity and
neurodegeneration . . . . . . . . . . . 851
Kyung-Sun Heo and
Hakjoo Lee and
Patrizia Nigro and
Tamlyn Thomas and
Nhat-Tu Le and
Eugene Chang and
Carolyn McClain and
Cynthia A. Reinhart-King and
Michael R. King and
Bradford C. Berk and
Keigi Fujiwara and
Chang-Hoon Woo and
Jun-ichi Abe PKC$ \zeta $ mediates disturbed
flow-induced endothelial apoptosis via
p53 SUMOylation . . . . . . . . . . . . 867
Ruchi Saraya and
Arjen M. Krikken and
Marten Veenhuis and
Ida J. van der Klei Peroxisome reintroduction in Hansenula
polymorpha requires Pex25 and Rho1 . . . 885
Junya Hasegawa and
Emi Tokuda and
Takeshi Tenno and
Kazuya Tsujita and
Haruko Sawai and
Hidekazu Hiroaki and
Tadaomi Takenawa and
Toshiki Itoh SH3YL1 regulates dorsal ruffle formation
by a novel phosphoinositide-binding
domain . . . . . . . . . . . . . . . . . 901
Lidia Hurtado and
Cristina Caballero and
Maria P. Gavilan and
Jesus Cardenas and
Michel Bornens and
Rosa M. Rios Disconnecting the Golgi ribbon from the
centrosome prevents directional cell
migration and ciliogenesis . . . . . . . 917
Deanna G. Wilson and
Khanhky Phamluong and
Li Li and
Mei Sun and
Tim C. Cao and
Peter S. Liu and
Zora Modrusan and
Wendy N. Sandoval and
Linda Rangell and
Richard A. D. Carano and
Andrew S. Peterson and
Mark J. Solloway Global defects in collagen secretion in
a Mia3/TANGO1 knockout mouse . . . . . . 935
Ben Short Cdks put Treslin on TopBP1 . . . . . . . ??
Ben Short Epac1 cAMPs out at nuclear pores . . . . ??
Ben Short Aurora A limits calcium release . . . . ??
Ben Short New TIPs for successfully growing
microtubules . . . . . . . . . . . . . . 955
Caitlin Sedwick David Bilder: Getting to know epithelia
inside and out . . . . . . . . . . . . . 956
Helge Ewers Septin pairs, a complex choreography . . 959
Mark C. Field and
Andrej Sali and
Michael P. Rout On a bender --- BARs, ESCRTs, COPs, and
finally getting your coat . . . . . . . 963
Wenjing Li and
Tomohiro Miki and
Takashi Watanabe and
Mai Kakeno and
Ikuko Sugiyama and
Kozo Kaibuchi and
Gohta Goshima EB1 promotes microtubule dynamics by
recruiting Sentin in \bionameDrosophila
cells . . . . . . . . . . . . . . . . . 973
Mei-Yao Lin and
Yu-Min Lin and
Te-chan Kao and
Hsiang-Hao Chuang and
Ruey-Hwa Chen PDZ-RhoGEF ubiquitination by
Cullin3--KLHL20 controls
neurotrophin-induced neurite outgrowth 985
Akiko Kumagai and
Anna Shevchenko and
Andrej Shevchenko and
William G. Dunphy Direct regulation of Treslin by
cyclin-dependent kinase is essential for
the onset of DNA replication . . . . . . 995
Martijn Gloerich and
Marjolein J. Vliem and
Esther Prummel and
Lars A. T. Meijer and
Marije G. A. Rensen and
Holger Rehmann and
Johannes L. Bos The nucleoporin RanBP2 tethers the cAMP
effector Epac1 and inhibits its
catalytic activity . . . . . . . . . . . 1009
Olga V. Plotnikova and
Elena N. Pugacheva and
Erica A. Golemis Aurora A kinase activity influences
calcium signaling in kidney cells . . . 1021
Daniela Trinca Bertazzi and
Bahtiyar Kurtulmus and
Gislene Pereira The cortical protein Lte1 promotes
mitotic exit by inhibiting the spindle
position checkpoint kinase Kin4 . . . . 1033
Robin M. Ricke and
Karthik B. Jeganathan and
Jan M. van Deursen Bub1 overexpression induces aneuploidy
and tumor formation through Aurora B
kinase hyperactivation . . . . . . . . . 1049
Bradley S. DeMay and
Xiaobo Bai and
Louisa Howard and
Patricia Occhipinti and
Rebecca A. Meseroll and
Elias T. Spiliotis and
Rudolf Oldenbourg and
Amy S. Gladfelter Septin filaments exhibit a dynamic,
paired organization that is conserved
from yeast to mammals . . . . . . . . . 1065
Babet van der Vaart and
Cristina Manatschal and
Ilya Grigoriev and
Vincent Olieric and
Susana Montenegro Gouveia and
Sa\vsa Bjeli\'c and
Jeroen Demmers and
Ivan Vorobjev and
Casper C. Hoogenraad and
Michel O. Steinmetz and
Anna Akhmanova SLAIN2 links microtubule plus
end--tracking proteins and controls
microtubule growth in interphase . . . . 1083
Steffi Gruschke and
Kirsten Kehrein and
Katharina Römpler and
Kerstin Gröne and
Lars Israel and
Axel Imhof and
Johannes M. Herrmann and
Martin Ott Cbp3--Cbp6 interacts with the yeast
mitochondrial ribosomal tunnel exit and
promotes cytochrome b synthesis and
assembly . . . . . . . . . . . . . . . . 1101
Yayoi Izu and
Mei Sun and
Daniela Zwolanek and
Guido Veit and
Valerie Williams and
Byeong Cha and
Karl J. Jepsen and
Manuel Koch and
David E. Birk Type XII collagen regulates osteoblast
polarity and communication during bone
formation . . . . . . . . . . . . . . . 1115
Ben Short Retinoic acid keeps Lingo-1 quiet . . . ??
Ben Short Cohesin and condensin spring into action ??
Ben Short miRNAs prevent a change of heart . . . . ??
Ben Short Cdc42 and Tinman march to the same beat 1133
Caitlin Sedwick Jagesh Shah: a quantitative approach to
cell biology . . . . . . . . . . . . . . 1134
Hiroki Oda and
Masatoshi Takeichi Structural and functional diversity of
cadherin at the adherens junction . . . 1137
Radhika Puttagunta and
André Schmandke and
Elisa Floriddia and
Perrine Gaub and
Natalie Fomin and
Norbert B. Ghyselinck and
Simone Di Giovanni RA-RAR-$ \beta $ counteracts
myelin-dependent inhibition of neurite
outgrowth via Lingo-1 repression . . . . 1147
Gary W. Kerr and
Sourav Sarkar and
Katherine L. Tibbles and
Mark Petronczki and
Jonathan B. A. Millar and
Prakash Arumugam Meiotic nuclear divisions in budding
yeast require PP2A$^{\rm
Cdc55}$-mediated antagonism of Net1
phosphorylation by Cdk . . . . . . . . . 1157
Andrew D. Stephens and
Julian Haase and
Leandra Vicci and
Russell M. Taylor and
Kerry Bloom Cohesin, condensin, and the
intramolecular centromere loop together
generate the mitotic chromatin spring 1167
Li Qian and
Joshua D. Wythe and
Jiandong Liu and
Jerome Cartry and
Georg Vogler and
Bhagyalaxmi Mohapatra and
Robyn T. Otway and
Yu Huang and
Isabelle N. King and
Marjorie Maillet and
Yi Zheng and
Timothy Crawley and
Ouarda Taghli-Lamallem and
Christopher Semsarian and
Sally Dunwoodie and
David Winlaw and
Richard P. Harvey and
Diane Fatkin and
Jeffrey A. Towbin and
Jeffery D. Molkentin and
Deepak Srivastava and
Karen Ocorr and
Benoit G. Bruneau and
Rolf Bodmer Tinman\slash Nkx2-5 acts via miR-1 and
upstream of Cdc42 to regulate heart
function across species . . . . . . . . 1181
Stefania Crippa and
Marco Cassano and
Graziella Messina and
Daniela Galli and
Beatriz G. Galvez and
Tomaz Curk and
Claudia Altomare and
Flavio Ronzoni and
Jaan Toelen and
Rik Gijsbers and
Zeger Debyser and
Stefan Janssens and
Blaz Zupan and
Antonio Zaza and
Giulio Cossu and
Maurilio Sampaolesi miR669a and miR669q prevent skeletal
muscle differentiation in postnatal
cardiac progenitors . . . . . . . . . . 1197
Farid Bizzari and
Adele L. Marston Cdc55 coordinates spindle assembly and
chromosome disjunction during meiosis 1213
Marina L. Ellefson and
Francis J. McNally CDK-1 inhibits meiotic spindle
shortening and dynein-dependent spindle
rotation in \bionameC. elegans . . . . . 1229
Jun Zhang and
Xuanli Yao and
Lauren Fischer and
Juan F. Abenza and
Miguel A. Peñalva and
Xin Xiang The p25 subunit of the dynactin complex
is required for dynein--early endosome
interaction . . . . . . . . . . . . . . 1245
Masaki Ishikawa and
Tsutomu Iwamoto and
Takashi Nakamura and
Andrew Doyle and
Satoshi Fukumoto and
Yoshihiko Yamada Pannexin 3 functions as an ER Ca$^{2+}$
channel, hemichannel, and gap junction
to promote osteoblast differentiation 1257
Hideki Yamaguchi and
Shuhei Yoshida and
Emi Muroi and
Nachi Yoshida and
Masahiro Kawamura and
Zen Kouchi and
Yoshikazu Nakamura and
Ryuichi Sakai and
Kiyoko Fukami Phosphoinositide $3$-kinase signaling
pathway mediated by p110$ \alpha $
regulates invadopodia formation . . . . 1275
Violaine D. Delorme-Walker and
Jeffrey R. Peterson and
Jonathan Chernoff and
Clare M. Waterman and
Gaudenz Danuser and
Céline DerMardirossian and
Gary M. Bokoch Pak1 regulates focal adhesion strength,
myosin IIA distribution, and actin
dynamics to optimize cell migration . . 1289
Lee B. Rivera and
Rolf A. Brekken SPARC promotes pericyte recruitment via
inhibition of endoglin-dependent TGF-$
\beta $1 activity . . . . . . . . . . . 1305
Mitch Leslie New Twist on cell migration . . . . . . ??
Mitch Leslie Bak activators get in the groove . . . . ??
Mitch Leslie SUMO defeats protein aggregates . . . . ??
Mitch Leslie The sarcoplasmic reticulum takes on a
supporting role . . . . . . . . . . . . 3
Caitlin Sedwick Carol Dieckmann: an eye on organellar
biology . . . . . . . . . . . . . . . . 4
Toren Finkel Signal transduction by reactive oxygen
species . . . . . . . . . . . . . . . . 7
Rachel Lander and
Kara Nordin and
Carole LaBonne The F-box protein Ppa is a common
regulator of core EMT factors Twist,
Snail, Slug, and Sip1 . . . . . . . . . 17
Jessica A. Talamas and
Martin W. Hetzer POM121 and Sun1 play a role in early
steps of interphase NPC assembly . . . . 27
Haiming Dai and
Alyson Smith and
X. Wei Meng and
Paula A. Schneider and
Yuan-Ping Pang and
Scott H. Kaufmann Transient binding of an activator BH3
domain to the Bak BH3-binding groove
initiates Bak oligomerization . . . . . 39
Petranka Krumova and
Erik Meulmeester and
Manuel Garrido and
Marilyn Tirard and
He-Hsuan Hsiao and
Guillaume Bossis and
Henning Urlaub and
Markus Zweckstetter and
Sebastian Kügler and
Frauke Melchior and
Mathias Bähr and
Jochen H. Weishaupt Sumoylation inhibits $ \alpha
$-synuclein aggregation and toxicity . . 49
Morihisa Fujita and
Reika Watanabe and
Nina Jaensch and
Maria Romanova-Michaelides and
Tadashi Satoh and
Masaki Kato and
Howard Riezman and
Yoshiki Yamaguchi and
Yusuke Maeda and
Taroh Kinoshita Sorting of GPI-anchored proteins into ER
exit sites by p24 proteins is dependent
on remodeled GPI . . . . . . . . . . . . 61
Dinari A. Harris and
Kevin Kim and
Kenji Nakahara and
Constanza Vásquez-Doorman and
Richard W. Carthew Cargo sorting to lysosome-related
organelles regulates siRNA-mediated gene
silencing . . . . . . . . . . . . . . . 77
Iwona M. Pranke and
Vincent Morello and
Joëlle Bigay and
Kimberley Gibson and
Jean-Marc Verbavatz and
Bruno Antonny and
Catherine L. Jackson $ \alpha $-Synuclein and ALPS motifs are
membrane curvature sensors whose
contrasting chemistry mediates selective
vesicle binding . . . . . . . . . . . . 89
David S. Gokhin and
Velia M. Fowler Cytoplasmic $ \gamma $-actin and
tropomodulin isoforms link to the
sarcoplasmic reticulum in skeletal
muscle fibers . . . . . . . . . . . . . 105
Richard M. Parton and
Russell S. Hamilton and
Graeme Ball and
Lei Yang and
C. Fiona Cullen and
Weiping Lu and
Hiroyuki Ohkura and
Ilan Davis A PAR-1-dependent orientation gradient
of dynamic microtubules directs
posterior cargo transport in the
\bionameDrosophila oocyte . . . . . . . 121
Yuko Nakajima and
Anthony Cormier and
Randall G. Tyers and
Adrianne Pigula and
Yutian Peng and
David G. Drubin and
Georjana Barnes Ipl1\slash Aurora-dependent
phosphorylation of Sli15/INCENP
regulates CPC--spindle interaction to
ensure proper microtubule dynamics . . . 137
Steffi Gruschke and
Kirsten Kehrein and
Katharina Römpler and
Kerstin Gröne and
Lars Israel and
Axel Imhof and
Johannes M. Herrmann and
Martin Ott Cbp3--Cbp6 interacts with the yeast
mitochondrial ribosomal tunnel exit and
promotes cytochrome b synthesis and
assembly . . . . . . . . . . . . . . . . 155
Olga V. Plotnikova and
Elena N. Pugacheva and
Erica A. Golemis Aurora A kinase activity influences
calcium signaling in kidney cells . . . 157
Ben Short AMPK amplifies Huntington's disease . . ??
Ben Short HJURP puts the centromere in place . . . ??
Ben Short Sphingomyelinase helps bones get their
minerals . . . . . . . . . . . . . . . . ??
Ben Short Microtubules follow septins' guidelines 161
Caitlin Sedwick Rüdiger Klein: Reading the guideposts for
axon guidance . . . . . . . . . . . . . 162
Zita Carvalho-Santos and
Juliette Azimzadeh and
José. B. Pereira-Leal and
Mónica Bettencourt-Dias Tracing the origins of centrioles,
cilia, and flagella . . . . . . . . . . 165
Xiomaris M. Cotto-Rios and
Mathew J. K. Jones and
Luca Busino and
Michele Pagano and
Tony T. Huang APC/C$^{\rm Cdh1}$-dependent proteolysis
of USP1 regulates the response to
UV-mediated DNA damage . . . . . . . . . 177
Jonathan R. Bowen and
Daniel Hwang and
Xiaobo Bai and
Dheeraj Roy and
Elias T. Spiliotis Septin GTPases spatially guide
microtubule organization and plus end
dynamics in polarizing epithelia . . . . 187
Anna Krzywicka-Racka and
Greenfield Sluder Repeated cleavage failure does not
establish centrosome amplification in
untransformed human cells . . . . . . . 199
Tz-Chuen Ju and
Hui-Mei Chen and
Jiun-Tsai Lin and
Ching-Pang Chang and
Wei-Cheng Chang and
Jheng-Jie Kang and
Cheng-Pu Sun and
Mi-Hua Tao and
Pang-Hsien Tu and
Chen Chang and
Dennis W. Dickson and
Yijuang Chern Nuclear translocation of AMPK-$ \alpha
$1 potentiates striatal
neurodegeneration in Huntington's
disease . . . . . . . . . . . . . . . . 209
Meghan C. Barnhart and
P. Henning J. L. Kuich and
Madison E. Stellfox and
Jared A. Ward and
Emily A. Bassett and
Ben E. Black and
Daniel R. Foltz HJURP is a CENP--A chromatin assembly
factor sufficient to form a functional
de novo kinetochore . . . . . . . . . . 229
Takao Nakata and
Shinsuke Niwa and
Yasushi Okada and
Franck Perez and
Nobutaka Hirokawa Preferential binding of a kinesin-1
motor to GTP-tubulin--rich microtubules
underlies polarized vesicle transport 245
Gregory D. Fairn and
Nicole L. Schieber and
Nicholas Ariotti and
Samantha Murphy and
Lars Kuerschner and
Richard I. Webb and
Sergio Grinstein and
Robert G. Parton High-resolution mapping reveals
topologically distinct cellular pools of
phosphatidylserine . . . . . . . . . . . 257
Zohreh Khavandgar and
Christophe Poirier and
Christopher J. Clarke and
Jingjing Li and
Nicholas Wang and
Marc D. McKee and
Yusuf A. Hannun and
Monzur Murshed A cell-autonomous requirement for
neutral sphingomyelinase 2 in bone
mineralization . . . . . . . . . . . . . 277
Anja Mai and
Stefan Veltel and
Teijo Pellinen and
Artur Padzik and
Eleanor Coffey and
Varpu Marjomäki and
Johanna Ivaska Competitive binding of Rab21 and
p120RasGAP to integrins regulates
receptor traffic and migration . . . . . 291
Molly Brunner and
Angélique Millon-Frémillon and
Genevieve Chevalier and
Inaam A. Nakchbandi and
Deane Mosher and
Marc R. Block and
Corinne Albig\`es-Rizo and
Daniel Bouvard Osteoblast mineralization requires $
\beta $1 integrin/ICAP-$1$-dependent
fibronectin deposition . . . . . . . . . 307
Jaewon Ko and
Gilberto J. Soler-Llavina and
Marc V. Fuccillo and
Robert C. Malenka and
Thomas C. Südhof Neuroligins\slash LRRTMs prevent
activity- and Ca$^{2+}$
/calmodulin-dependent synapse
elimination in cultured neurons . . . . 323
Basile Darbellay and
Serge Arnaudeau and
Charles R. Bader and
Stephane Konig and
Laurent Bernheim STIM1L is a new actin-binding splice
variant involved in fast repetitive
Ca$^{2+}$ release . . . . . . . . . . . 335
Deanna G. Wilson and
Khanhky Phamluong and
Li Li and
Mei Sun and
Tim C. Cao and
Peter S. Liu and
Zora Modrusan and
Wendy N. Sandoval and
Linda Rangell and
Richard A. D. Carano and
Andrew S. Peterson and
Mark J. Solloway Global defects in collagen secretion in
a Mia3/TANGO1 knockout mouse . . . . . . 347
Ben Short PARP retains Ku at double-strand breaks ??
Ben Short RNA targeting gets competitive . . . . . ??
Ben Short A COG in the retrograde transport
machinery . . . . . . . . . . . . . . . ??
Ben Short Nuclear envelope starts with a clean
sheet . . . . . . . . . . . . . . . . . 351
Caitlin Sedwick Ulrike Eggert: Big things from small
molecules . . . . . . . . . . . . . . . 352
Pamela A. Harvey and
Leslie A. Leinwand Cellular mechanisms of cardiomyopathy 355
C. Anne-Marie Couto and
Hong-Yu Wang and
Joanna C. A. Green and
Rhian Kiely and
Robert Siddaway and
Christine Borer and
Catherine J. Pears and
Nicholas D. Lakin PARP regulates nonhomologous end joining
through retention of Ku at double-strand
breaks . . . . . . . . . . . . . . . . . 367
Eva M. Gusnowski and
Martin Srayko Visualization of dynein-dependent
microtubule gliding at the cell cortex:
implications for spindle positioning . . 377
Thomas Becker and
Lena-Sophie Wenz and
Vivien Krüger and
Waltraut Lehmann and
Judith M. Müller and
Luise Goroncy and
Nicole Zufall and
Trevor Lithgow and
Bernard Guiard and
Agnieszka Chacinska and
Richard Wagner and
Chris Meisinger and
Nikolaus Pfanner The mitochondrial import protein Mim1
promotes biogenesis of multispanning
outer membrane proteins . . . . . . . . 387
Dra\vzen Papi\'c and
Katrin Krumpe and
Jovana Dukanovic and
Kai S. Dimmer and
Doron Rapaport Multispan mitochondrial outer membrane
protein Ugo1 follows a unique
Mim1-dependent import pathway . . . . . 397
Patima Sdek and
Peng Zhao and
Yaping Wang and
Chang-jiang Huang and
Christopher Y. Ko and
Peter C. Butler and
James N. Weiss and
W. Robb MacLellan Rb and p130 control cell cycle gene
silencing to maintain the postmitotic
phenotype in cardiac myocytes . . . . . 407
Lei Lu and
Mark S. Ladinsky and
Tomas Kirchhausen Formation of the postmitotic nuclear
envelope from extended ER cisternae
precedes nuclear pore assembly . . . . . 425
Ilham A. Muslimov and
Mihir V. Patel and
Arthur Rose and
Henri Tiedge Spatial code recognition in neuronal RNA
targeting: Role of RNA--hnRNP A2
interactions . . . . . . . . . . . . . . 441
Orly Laufman and
WanJin Hong and
Sima Lev The COG complex interacts directly with
Syntaxin 6 and positively regulates
endosome--to--TGN retrograde transport 459
Johannes Förtsch and
Eric Hummel and
Melanie Krist and
Benedikt Westermann The myosin-related motor protein Myo2 is
an essential mediator of bud-directed
mitochondrial movement in yeast . . . . 473
Patricia L. Martínez-Morales and
Ruth Diez del Corral and
Isabel Olivera-Martínez and
Alejandra C. Quiroga and
Raman M. Das and
Julio A. Barbas and
Kate G. Storey and
Aixa V. Morales FGF and retinoic acid activity gradients
control the timing of neural crest cell
emigration in the trunk . . . . . . . . 489
Ilaria Prada and
Julie Marchaland and
Paola Podini and
Lorenzo Magrassi and
Rosalba D'Alessandro and
Paola Bezzi and
Jacopo Meldolesi REST\slash NRSF governs the expression
of dense-core vesicle gliosecretion in
astrocytes . . . . . . . . . . . . . . . 505
Mitch Leslie RanBP2 stops importin-$ \beta $ from
running away . . . . . . . . . . . . . . ??
Mitch Leslie Lis1 finds new digs on the desmosome . . ??
Mitch Leslie Switching adherens junctions to seal
wounds . . . . . . . . . . . . . . . . . ??
Mitch Leslie Aurora B goes the distance . . . . . . . 509
Caitlin Sedwick Alejandro Sánchez Alvarado: Bootstrapping
flatworms into the molecular age . . . . 510
Bill Wickstead and
Keith Gull The evolution of the cytoskeleton . . . 513
Johanna S. Carroll and
Sarah E. Munchel and
Karsten Weis The DExD/H box ATPase Dhh1 functions in
translational repression, mRNA decay,
and processing body dynamics . . . . . . 527
Enxiu Wang and
Edward R. Ballister and
Michael A. Lampson Aurora B dynamics at centromeres create
a diffusion-based phosphorylation
gradient . . . . . . . . . . . . . . . . 539
Yazhong Tao and
Ronald L. Neppl and
Zhan-Peng Huang and
Jianfu Chen and
Ru-Hang Tang and
Ru Cao and
Yi Zhang and
Suk-Won Jin and
Da-Zhi Wang The histone methyltransferase Set7/9
promotes myoblast differentiation and
myofibril assembly . . . . . . . . . . . 551
Raquel Domínguez-Kelly and
Yusé Martín and
Stephane Koundrioukoff and
Marvin E. Tanenbaum and
Veronique A. J. Smits and
René H. Medema and
Michelle Debatisse and
Raimundo Freire Wee1 controls genomic stability during
replication by regulating the Mus81-Eme1
endonuclease . . . . . . . . . . . . . . 567
Katharina Rzeczkowski and
Knut Beuerlein and
Helmut Müller and
Oliver Dittrich-Breiholz and
Heike Schneider and
Daniela Kettner-Buhrow and
Helmut Holtmann and
Michael Kracht c-Jun N-terminal kinase phosphorylates
DCP1a to control formation of P bodies 581
Masakazu Hamada and
Anna Haeger and
Karthik B. Jeganathan and
Janine H. van Ree and
Liviu Malureanu and
Sarah Wälde and
Jomon Joseph and
Ralph H. Kehlenbach and
Jan M. van Deursen Ran-dependent docking of importin-$
\beta $ to RanBP2/Nup358 filaments is
essential for protein import and cell
viability . . . . . . . . . . . . . . . 597
Thomas D. Nightingale and
Ian J. White and
Emily L. Doyle and
Mark Turmaine and
Kimberly J. Harrison-Lavoie and
Kathleen F. Webb and
Louise P. Cramer and
Daniel F. Cutler Actomyosin II contractility expels von
Willebrand factor from Weibel--Palade
bodies during exocytosis . . . . . . . . 613
Kaelyn D. Sumigray and
Hsin Chen and
Terry Lechler Lis1 is essential for cortical
microtubule organization and desmosome
stability in the epidermis . . . . . . . 631
Katsutoshi Taguchi and
Takashi Ishiuchi and
Masatoshi Takeichi Mechanosensitive EPLIN-dependent
remodeling of adherens junctions
regulates epithelial reshaping . . . . . 643
Ben Short Vpr loosens chromatid ties . . . . . . . ??
Ben Short DLK makes neuronal cutbacks . . . . . . ??
Ben Short Arf1 doubles up to release vesicles . . ??
Ben Short Budding yeast star in their own biofilm 659
Caitlin Sedwick Ruth Lehmann: Germ cells do things
differently . . . . . . . . . . . . . . 660
Elizabeth H. Williams and
Tom Misteli New Tools for JCB . . . . . . . . . . . 663
Peter H. Thorpe and
David Alvaro and
Michael Lisby and
Rodney Rothstein Bringing Rad52 foci into focus . . . . . 665
Reinhard Windoffer and
Michael Beil and
Thomas M. Magin and
Rudolf E. Leube Cytoskeleton in motion: the dynamics of
keratin intermediate filaments in
epithelia . . . . . . . . . . . . . . . 669
Libu\vse Váchová and
Vratislav \vS\vtoví\vcek and
Otakar Hlavá\vcek and
Oleksandr Chernyavskiy and
Lud\vek \vSt\vepánek and
Lucie Kubínová and
Zdena Palková Flo11p, drug efflux pumps, and the
extracellular matrix cooperate to form
biofilm yeast colonies . . . . . . . . . 679
Mark T. Boyd and
Nikolina Vlatkovi\'c and
Carlos P. Rubbi The nucleolus directly regulates p53
export and degradation . . . . . . . . . 689
Shaun E. Peterson and
Yinyin Li and
Brian T. Chait and
Max E. Gottesman and
Richard Baer and
Jean Gautier Cdk1 uncouples CtIP-dependent resection
and Rad51 filament formation during
M-phase double-strand break repair . . . 705
Mari Shimura and
Yusuke Toyoda and
Kenta Iijima and
Masanobu Kinomoto and
Kenzo Tokunaga and
Kinya Yoda and
Mitsuhiro Yanagida and
Tetsutaro Sata and
Yukihito Ishizaka Epigenetic displacement of HP1 from
heterochromatin by HIV-1 Vpr causes
premature sister chromatid separation 721
Jason D. Berndt and
Atsushi Aoyagi and
Peitzu Yang and
Jamie N. Anastas and
Lan Tang and
Randall T. Moon Mindbomb 1, an E3 ubiquitin ligase,
forms a complex with RYK to activate
Wnt/$ \beta $-catenin signaling . . . . 737
Arundhati Sengupta Ghosh and
Bei Wang and
Christine D. Pozniak and
Mark Chen and
Ryan J. Watts and
Joseph W. Lewcock DLK induces developmental neuronal
degeneration via selective regulation of
proapoptotic JNK activity . . . . . . . 751
Rainer Beck and
Simone Prinz and
Petra Diestelkötter-Bachert and
Simone Röhling and
Frank Adolf and
Kathrin Hoehner and
Sonja Welsch and
Paolo Ronchi and
Britta Brügger and
John A. G. Briggs and
Felix Wieland Coatomer and dimeric ADP ribosylation
factor 1 promote distinct steps in
membrane scission . . . . . . . . . . . 765
Frank C. Brown and
Carmel H. Schindelhaim and
Suzanne R. Pfeffer GCC185 plays independent roles in Golgi
structure maintenance and AP-1-mediated
vesicle tethering . . . . . . . . . . . 779
Jennifer L. Rohn and
David Sims and
Tao Liu and
Marina Fedorova and
Frieder Schöck and
Joseph Dopie and
Maria K. Vartiainen and
Amy A. Kiger and
Norbert Perrimon and
Buzz Baum Comparative RNAi screening identifies a
conserved core metazoan actinome by
phenotype . . . . . . . . . . . . . . . 789
Jonathan H. Schatz and
Elisa Oricchio and
Andrew L. Wolfe and
Man Jiang and
Irina Linkov and
Jocelyn Maragulia and
Weiji Shi and
Zhigang Zhang and
Rajasekhar K. Vinagolu and
Nen C. Pagano and
John A. Porco and
Julie Teruya-Feldstein and
Neal Rosen and
Andrew D. Zelenetz and
Jerry Pelletier and
Hans-Guido Wendel Targeting cap-dependent translation
blocks converging survival signals by
AKT and PIM kinases in lymphoma . . . . ??
Shirly Becker-Herman and
Almut Meyer-Bahlburg and
Marc A. Schwartz and
Shaun W. Jackson and
Kelly L. Hudkins and
Chaohong Liu and
Blythe D. Sather and
Socheath Khim and
Denny Liggitt and
Wenxia Song and
Gregg J. Silverman and
Charles E. Alpers and
David J. Rawlings WASp-deficient B cells play a critical,
cell-intrinsic role in triggering
autoimmunity . . . . . . . . . . . . . . ??
Patrick Viatour and
Ursula Ehmer and
Louis A. Saddic and
Craig Dorrell and
Jesper B. Andersen and
Chenwei Lin and
Anne-Flore Zmoos and
Pawel K. Mazur and
Bethany E. Schaffer and
Austin Ostermeier and
Hannes Vogel and
Karl G. Sylvester and
Snorri S. Thorgeirsson and
Markus Grompe and
Julien Sage Notch signaling inhibits hepatocellular
carcinoma following inactivation of the
RB pathway . . . . . . . . . . . . . . . ??
Mitch Leslie p63 delegates during skin development ??
Mitch Leslie MCPH1 keeps chromosomes strung out . . . ??
Mitch Leslie A kinase makes a connection . . . . . . ??
Mitch Leslie Mnemonic microRNAs help make memories 809
Caitlin Sedwick Shinya Inoué: Lighting the way in
microscopy . . . . . . . . . . . . . . . 810
Lunhua Liu and
Carole A. Parent TOR kinase complexes and cell migration 815
Michael Y. Fessing and
Andrei N. Mardaryev and
Michal R. Gdula and
Andrey A. Sharov and
Tatyana Y. Sharova and
Valentina Rapisarda and
Konstantin B. Gordon and
Anna D. Smorodchenko and
Krzysztof Poterlowicz and
Giustina Ferone and
Yoshinori Kohwi and
Caterina Missero and
Terumi Kohwi-Shigematsu and
Vladimir A. Botchkarev p63 regulates Satb1 to control
tissue-specific chromatin remodeling
during development of the epidermis . . 825
Daisuke Yamashita and
Keishi Shintomi and
Takao Ono and
Ioannis Gavvovidis and
Detlev Schindler and
Heidemarie Neitzel and
Marc Trimborn and
Tatsuya Hirano MCPH1 regulates chromosome condensation
and shaping as a composite modulator of
condensin II . . . . . . . . . . . . . . 841
Ben Moree and
Corey B. Meyer and
Colin J. Fuller and
Aaron F. Straight CENP-C recruits M18BP1 to centromeres to
promote CENP--A chromatin assembly . . . 855
Elina Shteyn and
Lucy Pigati and
Heike Fölsch Arf6 regulates AP-1B-dependent sorting
in polarized epithelial cells . . . . . 873
Giordano Lippi and
Joern R. Steinert and
Emma L. Marczylo and
Sabina D'Oro and
Roberto Fiore and
Ian D. Forsythe and
Gerhard Schratt and
Michele Zoli and
Pierluigi Nicotera and
Kenneth W. Young Targeting of the Arpc3 actin nucleation
factor by miR-29a/b regulates dendritic
spine morphology . . . . . . . . . . . . 889
Yuejun Chen and
Feifei Wang and
Hui Long and
Ying Chen and
Ziyan Wu and
Lan Ma GRK5 promotes F-actin bundling and
targets bundles to membrane structures
to control neuronal morphogenesis . . . 905
Ling Cheng and
Cody Locke and
Graeme W. Davis S6 kinase localizes to the presynaptic
active zone and functions with PDK1 to
control synapse development . . . . . . 921
Mitch Leslie Fibers keep cilia regular . . . . . . . ??
Mitch Leslie TPX2 is a drag on Eg5 . . . . . . . . . ??
Mitch Leslie Mobile moesin helps mitotic cells
stretch out . . . . . . . . . . . . . . ??
Mitch Leslie Why a protein switches sides during
translation . . . . . . . . . . . . . . 3
Ben Short Howard Chang: Gene regulation in time
and space . . . . . . . . . . . . . . . 4
Cat M. Haglund and
Matthew D. Welch Pathogens and polymers: Microbe--host
interactions illuminate the cytoskeleton 7
Michael E. Werner and
Peter Hwang and
Fawn Huisman and
Peter Taborek and
Clare C. Yu and
Brian J. Mitchell Actin and microtubules drive
differential aspects of planar cell
polarity in multiciliated cells . . . . 19
Kensuke Ninomiya and
Naoyuki Kataoka and
Masatoshi Hagiwara Stress-responsive maturation of Clk1/4
pre-mRNAs promotes phosphorylation of SR
splicing factor . . . . . . . . . . . . 27
Pen-Jen Lin and
Candice G. Jongsma and
Shuren Liao and
Arthur E. Johnson Transmembrane segments of nascent
polytopic membrane proteins control
cytosol/ER targeting during membrane
integration . . . . . . . . . . . . . . 41
Pen-Jen Lin and
Candice G. Jongsma and
Martin R. Pool and
Arthur E. Johnson Polytopic membrane protein folding at
L17 in the ribosome tunnel initiates
cyclical changes at the translocon . . . 55
Carly Willenborg and
Jian Jing and
Christine Wu and
Hugo Matern and
Jerome Schaack and
Jemima Burden and
Rytis Prekeris Interaction between FIP5 and SNX18
regulates epithelial lumen formation . . 71
Nan Ma and
Janel Titus and
Alyssa Gable and
Jennifer L. Ross and
Patricia Wadsworth TPX2 regulates the localization and
activity of Eg5 in the mammalian mitotic
spindle . . . . . . . . . . . . . . . . 87
Chantal Roubinet and
Barbara Decelle and
Gaëtan Chicanne and
Jonas F. Dorn and
Bernard Payrastre and
François Payre and
Sébastien Carreno Molecular networks linked by Moesin
drive remodeling of the cell cortex
during mitosis . . . . . . . . . . . . . 99
Yi-Ru Pan and
Chien-Lin Chen and
Hong-Chen Chen FAK is required for the assembly of
podosome rosettes . . . . . . . . . . . 113
Carla Danussi and
Alessandra Petrucco and
Bruna Wassermann and
Eliana Pivetta and
Teresa Maria Elisa Modica and
Lisa Del Bel Belluz and
Alfonso Colombatti and
Paola Spessotto EMILIN1-$ \alpha $4\slash $ \alpha $9
integrin interaction inhibits dermal
fibroblast and keratinocyte
proliferation . . . . . . . . . . . . . 131
Michelle J. Doyle and
Sheng Zhou and
Kathleen Kelly Tanaka and
Addolorata Pisconti and
Nicholas H. Farina and
Brian P. Sorrentino and
Bradley B. Olwin Abcg2 labels multiple cell types in
skeletal muscle and participates in
muscle regeneration . . . . . . . . . . 147
Ben Short Good housekeeping maintains a healthy
liver . . . . . . . . . . . . . . . . . ??
Ben Short Twins activate! Form of a new centriole! ??
Ben Short Schwann cells cover their territory . . ??
Ben Short Locating a mitochondrial scaffold on the
map . . . . . . . . . . . . . . . . . . 167
Caitlin Sedwick Anna Akhmanova: Great tips on
microtubules . . . . . . . . . . . . . . 168
Katherine L. Wilson and
Scott C. Dawson Functional evolution of nuclear
structure . . . . . . . . . . . . . . . 171
Philipp Stelter and
Ruth Kunze and
Jessica Fischer and
Ed Hurt Probing the nucleoporin FG repeat
network defines structural and
functional features of the nuclear pore
complex . . . . . . . . . . . . . . . . 183
Julie Y. Yi and
Kassandra M. Ori-McKenney and
Richard J. McKenney and
Michael Vershinin and
Steven P. Gross and
Richard B. Vallee High-resolution imaging reveals indirect
coordination of opposite motors and a
role for LIS1 in high-load axonal
transport . . . . . . . . . . . . . . . 193
Rachel Kama and
Vydehi Kanneganti and
Christian Ungermann and
Jeffrey E. Gerst The yeast Batten disease orthologue Btn1
controls endosome-Golgi retrograde
transport via SNARE assembly . . . . . . 203
Natasha T. Snider and
Sujith V. W. Weerasinghe and
Amika Singla and
Jessica M. Leonard and
Shinichiro Hanada and
Philip C. Andrews and
Anna S. Lok and
M. Bishr Omary Energy determinants GAPDH and NDPK act
as genetic modifiers for hepatocyte
inclusion formation . . . . . . . . . . 217
Christopher W. Brownlee and
Joey E. Klebba and
Daniel W. Buster and
Gregory C. Rogers The Protein Phosphatase 2A regulatory
subunit Twins stabilizes Plk4 to induce
centriole amplification . . . . . . . . 231
Hiroyuki Nakajima and
Takuji Tanoue Lulu2 regulates the circumferential
actomyosin tensile system in epithelial
cells through p114RhoGEF . . . . . . . . 245
Ying-bei Chen and
Miguel A. Aon and
Yi-Te Hsu and
Lucian Soane and
Xinchen Teng and
J. Michael McCaffery and
Wen-Chih Cheng and
Bing Qi and
Hongmei Li and
Kambiz N. Alavian and
Margaret Dayhoff-Brannigan and
Shifa Zou and
Fernando J. Pineda and
Brian O'Rourke and
Young H. Ko and
Peter L. Pedersen and
Leonard K. Kaczmarek and
Elizabeth A. Jonas and
J. Marie Hardwick Bcl-x$_L$ regulates mitochondrial
energetics by stabilizing the inner
membrane potential . . . . . . . . . . . 263
Toshiyuki Bohgaki and
Julien Mozo and
Leonardo Salmena and
Elzbieta Matysiak-Zablocki and
Miyuki Bohgaki and
Otto Sanchez and
Andreas Strasser and
Anne Hakem and
Razqallah Hakem Caspase-8 inactivation in T cells
increases necroptosis and suppresses
autoimmunity in Bim$^{-/} - $ mice . . . 277
Monika S. Brill and
Jeff W. Lichtman and
Wesley Thompson and
Yi Zuo and
Thomas Misgeld Spatial constraints dictate glial
territories at murine neuromuscular
junctions . . . . . . . . . . . . . . . 293
Eusebio Perdiguero and
Pedro Sousa-Victor and
Vanessa Ruiz-Bonilla and
Merc\`e Jardí and
Carme Caelles and
Antonio L. Serrano and
Pura Muñoz-Cánoves p38/MKP-$1$-regulated AKT coordinates
macrophage transitions and resolution of
inflammation during tissue repair . . . 307
Suzanne Hoppins and
Sean R. Collins and
Ann Cassidy-Stone and
Eric Hummel and
Rachel M. DeVay and
Laura L. Lackner and
Benedikt Westermann and
Maya Schuldiner and
Jonathan S. Weissman and
Jodi Nunnari A mitochondrial-focused genetic
interaction map reveals a scaffold-like
complex required for inner membrane
organization in mitochondria . . . . . . 323
Zita Carvalho-Santos and
Juliette Azimzadeh and
José. B. Pereira-Leal and
Mónica Bettencourt-Dias Tracing the origins of centrioles,
cilia, and flagella . . . . . . . . . . 341
Ben Short Ran drags spindles through the Mud . . . ??
Ben Short PKA cuts down on HDAC4 signaling . . . . ??
Ben Short PLD gives nutritional advice to mTORC1 ??
Ben Short Imaging $ \beta $ amyloid's pore
performance . . . . . . . . . . . . . . 345
Caitlin Sedwick Benny Geiger: a force in the study of
focal adhesions . . . . . . . . . . . . 346
Matteo Bonazzi and
Pascale Cossart Impenetrable barriers or entry portals?
The role of cell--cell adhesion during
infection . . . . . . . . . . . . . . . 349
Eric F. Joyce and
Michael Pedersen and
Stanley Tiong and
Sanese K. White-Brown and
Anshu Paul and
Shelagh D. Campbell and
Kim S. McKim Drosophila ATM and ATR have distinct
activities in the regulation of meiotic
DNA damage and repair . . . . . . . . . 359
Brett Wee and
Christopher A. Johnston and
Kenneth E. Prehoda and
Chris Q. Doe Canoe binds RanGTP to promote Pins$^{\rm
TPR}$/Mud-mediated spindle orientation 369
Hyun Sub Hwang and
Sang Gil Hwang and
Jun-Ho Cho and
Ji Soo Chae and
Kyoung Wan Yoon and
Ssang-Goo Cho and
Eui-Ju Choi CIIA functions as a molecular switch for
the Rac1-specific GEF activity of SOS1 377
Seiji Matsumoto and
Motoshi Hayano and
Yutaka Kanoh and
Hisao Masai Multiple pathways can bypass the
essential role of fission yeast Hsk1
kinase in DNA replication initiation . . 387
Johannes Backs and
Barbara C. Worst and
Lorenz H. Lehmann and
David M. Patrick and
Zegeye Jebessa and
Michael M. Kreusser and
Qiang Sun and
Lan Chen and
Claudia Heft and
Hugo A. Katus and
Eric N. Olson Selective repression of MEF2 activity by
PKA-dependent proteolysis of HDAC4 . . . 403
Nam Hee Kim and
Hyun Sil Kim and
Xiao-Yan Li and
Inhan Lee and
Hyung-Seok Choi and
Shi Eun Kang and
So Young Cha and
Joo Kyung Ryu and
Dojun Yoon and
Eric R. Fearon and
R. Grant Rowe and
Sanghyuk Lee and
Christopher A. Maher and
Stephen J. Weiss and
Jong In Yook A p53/miRNA-34 axis regulates
Snail1-dependent cancer cell
epithelial--mesenchymal transition . . . 417
Mee-Sup Yoon and
Guangwei Du and
Jonathan M. Backer and
Michael A. Frohman and
Jie Chen Class III PI-3-kinase activates
phospholipase D in an amino
acid--sensing mTORC1 pathway . . . . . . 435
Eleni Petsalaki and
Tonia Akoumianaki and
Elizabeth J. Black and
David A. F. Gillespie and
George Zachos Phosphorylation at serine 331 is
required for Aurora B activation . . . . 449
Tiina Tamm and
Agnes Grallert and
Emily P. S. Grossman and
Isabel Alvarez-Tabares and
Frances E. Stevens and
Iain M. Hagan Brr6 drives the
\bionameSchizosaccharomyces pombe
spindle pole body nuclear envelope
insertion/extrusion cycle . . . . . . . 467
Qian Chen and
Thomas D. Pollard Actin filament severing by cofilin is
more important for assembly than
constriction of the cytokinetic
contractile ring . . . . . . . . . . . . 485
Pengbo Wang and
Christoph Ballestrem and
Charles H. Streuli The C terminus of talin links integrins
to cell cycle progression . . . . . . . 499
Angelo Demuro and
Martin Smith and
Ian Parker Single-channel Ca$^{2+}$ imaging
implicates A$ \beta $1-42 amyloid pores
in Alzheimer's disease pathology . . . . 515
Matteo Bonazzi and
Lavanya Vasudevan and
Adeline Mallet and
Martin Sachse and
Anna Sartori and
Marie-Christine Prevost and
Allison Roberts and
Sabrina B. Taner and
Jeremy D. Wilbur and
Frances M. Brodsky and
Pascale Cossart Clathrin phosphorylation is required for
actin recruitment at sites of bacterial
adhesion and internalization . . . . . . 525
Ben Short Bridging the gap between atlastin
conformations . . . . . . . . . . . . . ??
Ben Short For Myo4p, two heads are better than one ??
Ben Short A new spin on radial spokes . . . . . . ??
Ben Short Setting a new standard for kinetochores 539
Caitlin Sedwick Denise Montell: Lighting the way in
border cell migration . . . . . . . . . 540
Stephanie L. Maiden and
Jeff Hardin The secret life of $ \alpha $-catenin:
Moonlighting in morphogenesis . . . . . 543
Ana Carmena and
Aljona Makarova and
Stephan Speicher The Rap1--Rgl--Ral signaling network
regulates neuroblast cortical polarity
and spindle orientation . . . . . . . . 553
Valerie C. Coffman and
Pengcheng Wu and
Mark R. Parthun and
Jian-Qiu Wu CENP-A exceeds microtubule attachment
sites in centromere clusters of both
budding and fission yeast . . . . . . . 563
Josh Lawrimore and
Kerry S. Bloom and
E. D. Salmon Point centromeres contain more than a
single centromere-specific Cse4
(CENP--A) nucleosome . . . . . . . . . . 573
Jun-Song Chen and
Lucy X. Lu and
Melanie D. Ohi and
Kevin M. Creamer and
Chauca English and
Janet F. Partridge and
Ryoma Ohi and
Kathleen L. Gould Cdk1 phosphorylation of the kinetochore
protein Nsk1 prevents error-prone
chromosome segregation . . . . . . . . . 583
Zuni I. Bassi and
Koen J. Verbrugghe and
Luisa Capalbo and
Stephen Gregory and
Emilie Montembault and
David M. Glover and
Pier Paolo D'Avino Sticky/Citron kinase maintains proper
RhoA localization at the cleavage site
during cytokinesis . . . . . . . . . . . 595
Jeanne Morin-Leisk and
Simran G. Saini and
Xin Meng and
Alexander M. Makhov and
Peijun Zhang and
Tina H. Lee An intramolecular salt bridge drives the
soluble domain of GTP-bound atlastin
into the postfusion conformation . . . . 605
Sebastian Specht and
Stephanie B. M. Miller and
Axel Mogk and
Bernd Bukau Hsp42 is required for sequestration of
protein aggregates into deposition sites
in \bionameSaccharomyces cerevisiae . . 617
Elena B. Krementsova and
Alex R. Hodges and
Carol S. Bookwalter and
Thomas E. Sladewski and
Mirko Travaglia and
H. Lee Sweeney and
Kathleen M. Trybus Two single-headed myosin V motors bound
to a tetrameric adapter protein form a
processive complex . . . . . . . . . . . 631
Christian Schulz and
Oleksandr Lytovchenko and
Jonathan Melin and
Agnieszka Chacinska and
Bernard Guiard and
Piotr Neumann and
Ralf Ficner and
Olaf Jahn and
Bernhard Schmidt and
Peter Rehling Tim50's presequence receptor domain is
essential for signal driven transport
across the TIM23 complex . . . . . . . . 643
Derek C. Prosser and
Theodore G. Drivas and
Lymarie Maldonado-Báez and
Beverly Wendland Existence of a novel
clathrin-independent endocytic pathway
in yeast that depends on Rho1 and formin 657
Gaia Pigino and
Khanh Huy Bui and
Aditi Maheshwari and
Pietro Lupetti and
Dennis Diener and
Takashi Ishikawa Cryoelectron tomography of radial spokes
in cilia and flagella . . . . . . . . . 673
Toshihide Kurihara and
Peter D. Westenskow and
Tim U. Krohne and
Edith Aguilar and
Randall S. Johnson and
Martin Friedlander Astrocyte pVHL and HIF-$ \alpha $
isoforms are required for
embryonic-to-adult vascular transition
in the eye . . . . . . . . . . . . . . . 689
Mitch Leslie VPS35 leaves endosomes lost in
transition . . . . . . . . . . . . . . . ??
Mitch Leslie The actomyosin ring bulks up . . . . . . ??
Mitch Leslie HPK1 tones down the T cell receptor . . ??
Mitch Leslie How eisosomes help the plasma membrane
get organized . . . . . . . . . . . . . 705
Caitlin Sedwick Vann Bennett: How ankyrin holds it all
together . . . . . . . . . . . . . . . . 706
Eric M. Pietras and
Matthew R. Warr and
Emmanuelle Passegué Cell cycle regulation in hematopoietic
stem cells . . . . . . . . . . . . . . . 709
Kimihide Hayakawa and
Hitoshi Tatsumi and
Masahiro Sokabe Actin filaments function as a tension
sensor by tension-dependent binding of
cofilin to the filament . . . . . . . . 721
Xiao-Yan Li and
Xiaoming Zhou and
R. Grant Rowe and
Yuexian Hu and
David D. Schlaepfer and
Dusko Ili\'c and
Gregory Dressler and
Ann Park and
Jun-Lin Guan and
Stephen J. Weiss Snail1 controls epithelial--mesenchymal
lineage commitment in focal adhesion
kinase--null embryonic cells . . . . . . 729
Marie Regairaz and
Yong-Wei Zhang and
Haiqing Fu and
Keli K. Agama and
Nalini Tata and
Surbhi Agrawal and
Mirit I. Aladjem and
Yves Pommier Mus81-mediated DNA cleavage resolves
replication forks stalled by
topoisomerase I--DNA complexes . . . . . 739
Carla P. Guimaraes and
Jan E. Carette and
Malini Varadarajan and
John Antos and
Maximilian W. Popp and
Eric Spooner and
Thijn R. Brummelkamp and
Hidde L. Ploegh Identification of host cell factors
required for intoxication through use of
modified cholera toxin . . . . . . . . . 751
Lei Wen and
Fu-Lei Tang and
Yan Hong and
Shi-Wen Luo and
Chun-Lei Wang and
Wanxia He and
Chengyong Shen and
Ji-Ung Jung and
Fei Xiong and
Dae-hoon Lee and
Quan-Guang Zhang and
Darrell Brann and
Tae-Wan Kim and
Riqiang Yan and
Lin Mei and
Wen-Cheng Xiong VPS35 haploinsufficiency increases
Alzheimer's disease neuropathology . . . 765
Deborah Zyss and
Hani Ebrahimi and
Fanni Gergely Casein kinase I delta controls
centrosome positioning during T cell
activation . . . . . . . . . . . . . . . 781
Meredith E. K. Calvert and
Graham D. Wright and
Fong Yew Leong and
Keng-Hwee Chiam and
Yinxiao Chen and
Gregory Jedd and
Mohan K. Balasubramanian Myosin concentration underlies cell
size-dependent scalability of actomyosin
ring constriction . . . . . . . . . . . 799
Moshe S. Kim and
Carol D. Froese and
Mathew P. Estey and
William S. Trimble SEPT9 occupies the terminal positions in
septin octamers and mediates
polymerization-dependent functions in
abscission . . . . . . . . . . . . . . . 815
Shirin Meher Pocha and
Anna Shevchenko and
Elisabeth Knust Crumbs regulates rhodopsin transport by
interacting with and stabilizing myosin
V . . . . . . . . . . . . . . . . . . . 827
Rémi Lasserre and
Céline Cuche and
Ronnie Blecher-Gonen and
Evgeny Libman and
Elise Biquand and
Anne Danckaert and
Deborah Yablonski and
Andrés Alcover and
Vincenzo Di Bartolo Release of
serine/threonine-phosphorylated adaptors
from signaling microclusters
down-regulates T cell activation . . . . 839
Sébastien Nola and
Reiko Daigaku and
Kasia Smolarczyk and
Maryke Carstens and
Belen Martin-Martin and
Gregory Longmore and
Maryse Bailly and
Vania M. M. Braga Ajuba is required for Rac activation and
maintenance of E-cadherin adhesion . . . 855
Beate K. Straub and
Steffen Rickelt and
Ralf Zimbelmann and
Christine Grund and
Caecilia Kuhn and
Marcus Iken and
Michael Ott and
Peter Schirmacher and
Werner W. Franke E--N-cadherin heterodimers define novel
adherens junctions connecting
endoderm-derived cells . . . . . . . . . 873
Lena Karotki and
Juha T. Huiskonen and
Christopher J. Stefan and
Natasza E. Zió\lkowska and
Robyn Roth and
Michal A. Surma and
Nevan J. Krogan and
Scott D. Emr and
John Heuser and
Kay Grünewald and
Tobias C. Walther Eisosome proteins assemble into a
membrane scaffold . . . . . . . . . . . 889
Marco A. O. Magalhaes and
Daniel R. Larson and
Christopher C. Mader and
Jose Javier Bravo-Cordero and
Hava Gil-Henn and
Matthew Oser and
Xiaoming Chen and
Anthony J. Koleske and
John Condeelis Cortactin phosphorylation regulates cell
invasion through a pH-dependent pathway 903
Ben Short Lipid droplets fatten up with Fsp27 . . ??
Ben Short CUPS provide a handle on Acb1 secretion ??
Ben Short Cell death helps give closure . . . . . ??
Ben Short Shs1 rounds out the septin repertoire 923
Caitlin Sedwick Michael Overholtzer: Answering
existential questions on entosis . . . . 924
Tim P. Levine Lipid traffic: Osh4p makes an unexpected
exchange . . . . . . . . . . . . . . . . 927
Hiroshi Ashida and
Hitomi Mimuro and
Michinaga Ogawa and
Taira Kobayashi and
Takahito Sanada and
Minsoo Kim and
Chihiro Sasakawa Cell death and infection: a double-edged
sword for host and pathogen survival . . 931
Eric Alix and
Shaeri Mukherjee and
Craig R. Roy Subversion of membrane transport
pathways by vacuolar pathogens . . . . . 943
Jingyi Gong and
Zhiqi Sun and
Lizhen Wu and
Wenyi Xu and
Nicole Schieber and
Dijin Xu and
Guanghou Shui and
Hongyuan Yang and
Robert G. Parton and
Peng Li Fsp27 promotes lipid droplet growth by
lipid exchange and transfer at lipid
droplet contact sites . . . . . . . . . 953
Maud de Saint-Jean and
Vanessa Delfosse and
Dominique Douguet and
Gaëtan Chicanne and
Bernard Payrastre and
William Bourguet and
Bruno Antonny and
Guillaume Drin Osh4p exchanges sterols for
phosphatidylinositol $4$-phosphate
between lipid bilayers . . . . . . . . . 965
Caroline Bruns and
J. Michael McCaffery and
Amy J. Curwin and
Juan M. Duran and
Vivek Malhotra Biogenesis of a novel compartment for
autophagosome-mediated unconventional
protein secretion . . . . . . . . . . . 979
Galo Garcia and
Aurelie Bertin and
Zhu Li and
Yi Song and
Michael A. McMurray and
Jeremy Thorner and
Eva Nogales Subunit-dependent modulation of septin
assembly: Budding yeast septin Shs1
promotes ring and gauze formation . . . 993
Kazuya Hori and
Anindya Sen and
Tom Kirchhausen and
Spyros Artavanis-Tsakonas Synergy between the ESCRT--III complex
and Deltex defines a ligand-independent
Notch signal . . . . . . . . . . . . . . 1005
Aikaterini Daskalaki and
Nevine A. Shalaby and
Kristina Kux and
Giorgos Tsoumpekos and
George D. Tsibidis and
Marc A. T. Muskavitch and
Christos Delidakis Distinct intracellular motifs of Delta
mediate its ubiquitylation and
activation by Mindbomb1 and Neuralized 1017
Peter W. Janes and
Bettina Griesshaber and
Lakmali Atapattu and
Eva Nievergall and
Linda L. Hii and
Anneloes Mensinga and
Chanly Chheang and
Bryan W. Day and
Andrew W. Boyd and
Philippe I. Bastiaens and
Claus Jòrgensen and
Tony Pawson and
Martin Lackmann Eph receptor function is modulated by
heterooligomerization of A and B type
Eph receptors . . . . . . . . . . . . . 1033
Yoshifumi Yamaguchi and
Naomi Shinotsuka and
Keiko Nonomura and
Kiwamu Takemoto and
Keisuke Kuida and
Hiroki Yosida and
Masayuki Miura Live imaging of apoptosis in a novel
transgenic mouse highlights its role in
neural tube closure . . . . . . . . . . 1047
Christopher L. Brett and
Rachael L. Plemel and
Braden T. Lobingier and
Marissa Vignali and
Stanley Fields and
Alexey J. Merz Efficient termination of vacuolar Rab
GTPase signaling requires coordinated
action by a GAP and a protein kinase . . 1061
Lukas Kenner and
Astrid Hoebertz and
F. Timo Beil and
Niamh Keon and
Florian Karreth and
Robert Eferl and
Harald Scheuch and
Agnieszka Szremska and
Michael Amling and
Marina Schorpp-Kistner and
Peter Angel and
Erwin F. Wagner Mice lacking JunB are osteopenic due to
cell-autonomous osteoblast and
osteoclast defects . . . . . . . . . . . 1063
Mitch Leslie Shining new light on the function of
Aurora A . . . . . . . . . . . . . . . . ??
Mitch Leslie Protocadherins bring cells together . . ??
Mitch Leslie Cdc6 licenses tumor growth . . . . . . . ??
Mitch Leslie Neuregulins show their support for
neuromuscular junctions . . . . . . . . 1067
Caitlin Sedwick Rong Li: Tipping the balance in cell
biology . . . . . . . . . . . . . . . . 1068
Joe Grove and
Mark Marsh The cell biology of receptor-mediated
virus entry . . . . . . . . . . . . . . 1071
Anne Marie Krachler and
Andrew R. Woolery and
Kim Orth Manipulation of kinase signaling by
bacterial pathogens . . . . . . . . . . 1083
Kwanwoo Lee and
Kunsoo Rhee PLK1 phosphorylation of pericentrin
initiates centrosome maturation at the
onset of mitosis . . . . . . . . . . . . 1093
Nadia Hégarat and
Ewan Smith and
Gowri Nayak and
Shunichi Takeda and
Patrick A. Eyers and
Helfrid Hochegger Aurora A and Aurora B jointly coordinate
chromosome segregation and anaphase
microtubule dynamics . . . . . . . . . . 1103
Michelle R. Emond and
Sayantanee Biswas and
Cheasequah J. Blevins and
James D. Jontes A complex of Protocadherin-19 and
N-cadherin mediates a novel mechanism of
cell adhesion . . . . . . . . . . . . . 1115
Maria Sideridou and
Roubini Zakopoulou and
Konstantinos Evangelou and
Michalis Liontos and
Athanassios Kotsinas and
Emmanouil Rampakakis and
Sarantis Gagos and
Kaoru Kahata and
Kristina Grabusic and
Kalliopi Gkouskou and
Ioannis P. Trougakos and
Evangelos Kolettas and
Alexandros G. Georgakilas and
Sinisa Volarevic and
Aristides G. Eliopoulos and
Maria Zannis-Hadjopoulos and
Aristidis Moustakas and
Vassilis G. Gorgoulis Cdc6 expression represses E-cadherin
transcription and activates adjacent
replication origins . . . . . . . . . . 1123
María Verónica Baez and
Luciana Luchelli and
Darío Maschi and
Martín Habif and
Malena Pascual and
María Gabriela Thomas and
Graciela Lidia Boccaccio Smaug1 mRNA-silencing foci respond to
NMDA and modulate synapse formation . . 1141
Zhao Wang and
Huisheng Liu and
Yiwen Gu and
Edwin R. Chapman Reconstituted synaptotagmin I mediates
vesicle docking, priming, and fusion . . 1159
Nadine Schmidt and
Mohammed Akaaboune and
Nadesan Gajendran and
Isabel Martinez-Peña y Valenzuela and
Sarah Wakefield and
Raphael Thurnheer and
Hans Rudolf Brenner Neuregulin\slash ErbB regulate
neuromuscular junction development by
phosphorylation of $ \alpha
$-dystrobrevin . . . . . . . . . . . . . 1171
Oxana E. Nekrasova and
Evangeline V. Amargo and
William O. Smith and
Jing Chen and
Geri E. Kreitzer and
Kathleen J. Green Desmosomal cadherins utilize distinct
kinesins for assembly into desmosomes 1185
Matteo Bonazzi and
Pascale Cossart Impenetrable barriers or entry portals?
The role of cell--cell adhesion during
infection . . . . . . . . . . . . . . . 1205
Ben Short Ubiquitylation keeps the nucleus moving ??
Ben Short How meiotic chromosomes meet their match ??
Ben Short A firmer understanding of muscle
fibrosis . . . . . . . . . . . . . . . . ??
Ben Short Building up actin at adherens junctions 3
Caitlin Sedwick Keith Burridge: Cultivating knowledge on
Rho . . . . . . . . . . . . . . . . . . 4
Jack T. Wang and
Zachary A. Medress and
Ben A. Barres Axon degeneration: Molecular mechanisms
of a self-destruction pathway . . . . . 7
Akira Hayakawa and
Anna Babour and
Lucie Sengmanivong and
Catherine Dargemont Ubiquitylation of the nuclear pore
complex controls nuclear migration
during mitosis in S. cerevisiae . . . . 19
Jason Howitt and
Jenny Lackovic and
Ley-Hian Low and
Adam Naguib and
Alison Macintyre and
Choo-Peng Goh and
Jennifer K. Callaway and
Vicki Hammond and
Tim Thomas and
Matthew Dixon and
Ulrich Putz and
John Silke and
Perry Bartlett and
Baoli Yang and
Sharad Kumar and
Lloyd C. Trotman and
Seong-Seng Tan Ndfip1 regulates nuclear Pten import in
vivo to promote neuronal survival
following cerebral ischemia . . . . . . 29
Kathleen Zylbersztejn and
Maja Petkovic and
Andrea Burgo and
Marie Deck and
Sonia Garel and
Séverine Marcos and
Evelyne Bloch-Gallego and
Fatiha Nothias and
Guido Serini and
Dominique Bagnard and
Thomas Binz and
Thierry Galli The vesicular SNARE Synaptobrevin is
required for Semaphorin 3A axonal
repulsion . . . . . . . . . . . . . . . 37
David J. Wynne and
Ofer Rog and
Peter M. Carlton and
Abby F. Dernburg Dynein-dependent processive chromosome
motions promote homologous pairing in
\bionameC. elegans meiosis . . . . . . . 47
Nikolaos Giagtzoglou and
Shinya Yamamoto and
Diana Zitserman and
Hillary K. Graves and
Karen L. Schulze and
Hao Wang and
Hayley Klein and
Fabrice Roegiers and
Hugo J. Bellen dEHBP1 controls exocytosis and recycling
of Delta during asymmetric divisions . . 65
Donglei Zhang and
Nora R. Isack and
Doreen R. Glodowski and
Jie Liu and
Carlos Chih-Hsiung Chen and
X. Z. Shawn Xu and
Barth D. Grant and
Christopher Rongo RAB-6.2 and the retromer regulate
glutamate receptor recycling through a
retrograde pathway . . . . . . . . . . . 85
Julia K. Gilden and
Sebastian Peck and
Yi-Chun M. Chen and
Matthew F. Krummel The septin cytoskeleton facilitates
membrane retraction during motility and
blebbing . . . . . . . . . . . . . . . . 103
Vivian W. Tang and
William M. Brieher $ \alpha $-Actinin-4\slash FSGS1 is
required for Arp2/$3$-dependent actin
assembly at the adherens junction . . . 115
Yamei Yu and
Jianghai Zhu and
Li-Zhi Mi and
Thomas Walz and
Hao Sun and
JianFeng Chen and
Timothy A. Springer Structural specializations of $ \alpha_4
\beta_7 $, an integrin that mediates
rolling adhesion . . . . . . . . . . . . 131
Nikola Arsic and
Nawal Bendris and
Marion Peter and
Christina Begon-Pescia and
Cosette Rebouissou and
Gilles Gadéa and
Nathalie Bouquier and
Frédéric Bibeau and
Bénédicte Lemmers and
Jean Marie Blanchard A novel function for Cyclin A2: Control
of cell invasion via RhoA signaling . . 147
Esther Ardite and
Eusebio Perdiguero and
Berta Vidal and
Susana Gutarra and
Antonio L. Serrano and
Pura Muñoz-Cánoves PAI-$1$-regulated miR-21 defines a novel
age-associated fibrogenic pathway in
muscular dystrophy . . . . . . . . . . . 163
Carla Danussi and
Alessandra Petrucco and
Bruna Wassermann and
Eliana Pivetta and
Teresa Maria Elisa Modica and
Lisa Del Bel Belluz and
Alfonso Colombatti and
Paola Spessotto EMILIN1-$ \alpha $4\slash $ \alpha $9
integrin interaction inhibits dermal
fibroblast and keratinocyte
proliferation . . . . . . . . . . . . . 177
Leslie Mitch Licensing factors lose their credentials ??
Leslie Mitch n-Syb makes a dangerous delivery . . . . ??
Leslie Mitch DGK-$ \alpha $ keeps integrins close to
the edge . . . . . . . . . . . . . . . . ??
Mitch Leslie Spare the Rod1, spoil transporter
endocytosis . . . . . . . . . . . . . . 181
Caitlin Sedwick Tobias Walther: Floating ideas on lipids 182
Bryan Serrels and
Margaret C. Frame FAK and talin: Who is taking whom to the
integrin engagement party? . . . . . . . 185
Ana Maria Rojas and
Gloria Fuentes and
Antonio Rausell and
Alfonso Valencia The Ras protein superfamily:
Evolutionary tree and role of conserved
amino acids . . . . . . . . . . . . . . 189
Xiao Zhou and
Katja Graumann and
David E. Evans and
Iris Meier Novel plant SUN--KASH bridges are
involved in RanGAP anchoring and nuclear
shape determination . . . . . . . . . . 203
Mathias J. Gerl and
Julio L. Sampaio and
Severino Urban and
Lucie Kalvodova and
Jean-Marc Verbavatz and
Beth Binnington and
Dirk Lindemann and
Clifford A. Lingwood and
Andrej Shevchenko and
Cornelia Schroeder and
Kai Simons Quantitative analysis of the lipidomes
of the influenza virus envelope and MDCK
cell apical membrane . . . . . . . . . . 213
Christine Lawson and
Ssang-Taek Lim and
Sean Uryu and
Xiao Lei Chen and
David A. Calderwood and
David D. Schlaepfer FAK promotes recruitment of talin to
nascent adhesions to control cell
motility . . . . . . . . . . . . . . . . 223
Remi Sonneville and
Matthieu Querenet and
Ashley Craig and
Anton Gartner and
J. Julian Blow The dynamics of replication licensing in
live \bionameCaenorhabditis elegans
embryos . . . . . . . . . . . . . . . . 233
Michel Becuwe and
Neide Vieira and
David Lara and
Jéssica Gomes-Rezende and
Carina Soares-Cunha and
Margarida Casal and
Rosine Haguenauer-Tsapis and
Olivier Vincent and
Sandra Paiva and
Sébastien Léon A molecular switch on an arrestin-like
protein relays glucose signaling to
transporter endocytosis . . . . . . . . 247
Adam Haberman and
W. Ryan Williamson and
Daniel Epstein and
Dong Wang and
Srisha Rina and
Ian A. Meinertzhagen and
P. Robin Hiesinger The synaptic vesicle SNARE neuronal
Synaptobrevin promotes endolysosomal
degradation and prevents
neurodegeneration . . . . . . . . . . . 261
Elena Rainero and
Patrick T. Caswell and
Patricia A. J. Muller and
Joan Grindlay and
Mary W. McCaffrey and
Qifeng Zhang and
Michael J. O. Wakelam and
Karen H. Vousden and
Andrea Graziani and
Jim C. Norman Diacylglycerol kinase $ \alpha $
controls RCP-dependent integrin
trafficking to promote invasive
migration . . . . . . . . . . . . . . . 277
Oxana E. Nekrasova and
Evangeline V. Amargo and
William O. Smith and
Jing Chen and
Geri E. Kreitzer and
Kathleen J. Green Desmosomal cadherins utilize distinct
kinesins for assembly into desmosomes 297
Ben Short A pyrimidine scheme to restore mRNA
export . . . . . . . . . . . . . . . . . ??
Ben Short Myelinated axons need a 4.1G connection ??
Ben Short Focal adhesions degrade the ECM . . . . ??
Ben Short Stress fibers guide focal adhesions to
maturity . . . . . . . . . . . . . . . . 301
Caitlin Sedwick Pamela Silver: Synthesizing a new
biology . . . . . . . . . . . . . . . . 302
Jimmy Ouellet and
Yves Barral Organelle segregation during mitosis:
Lessons from asymmetrically dividing
cells . . . . . . . . . . . . . . . . . 305
Liang Zhang and
Priyabrata Das and
Mirco Schmolke and
Balaji Manicassamy and
Yaming Wang and
Xiaoyi Deng and
Ling Cai and
Benjamin P. Tu and
Christian V. Forst and
Michael G. Roth and
David E. Levy and
Adolfo García-Sastre and
Jef de Brabander and
Margaret A. Phillips and
Beatriz M. A. Fontoura Inhibition of pyrimidine synthesis
reverses viral virulence factor-mediated
block of mRNA nuclear export . . . . . . 315
Chantal Christis and
Sean Munro The small G protein Arl1 directs the
trans-Golgi-specific targeting of the
Arf1 exchange factors BIG1 and BIG2 . . 327
Aleksandra Ivanovic and
Ido Horresh and
Neev Golan and
Ivo Spiegel and
Helena Sabanay and
Shahar Frechter and
Shinichi Ohno and
Nobuo Terada and
Wiebke Möbius and
Jack Rosenbluth and
Nils Brose and
Elior Peles The cytoskeletal adapter protein 4.1G
organizes the internodes in peripheral
myelinated nerves . . . . . . . . . . . 337
Inna V. Nechipurenko and
Heather T. Broihier FoxO limits microtubule stability and is
itself negatively regulated by
microtubule disruption . . . . . . . . . 345
Patrick W. Oakes and
Yvonne Beckham and
Jonathan Stricker and
Margaret L. Gardel Tension is required but not sufficient
for focal adhesion maturation without a
stress fiber template . . . . . . . . . 363
Yu Wang and
Mark A. McNiven Invasive matrix degradation at focal
adhesions occurs via protease
recruitment by a FAK--p130Cas complex 375
Christine Lawson and
Ssang-Taek Lim and
Sean Uryu and
Xiao Lei Chen and
David A. Calderwood and
David D. Schlaepfer FAK promotes recruitment of talin to
nascent adhesions to control cell
motility . . . . . . . . . . . . . . . . 387
Mitch Leslie No crystal structure? No problem . . . . ??
Mitch Leslie Slow but steady for NF-$ \kappa $B . . . ??
Mitch Leslie Caspase conspiracy sets up cells for
death . . . . . . . . . . . . . . . . . ??
Mitch Leslie Knl1 shows another face . . . . . . . . 391
Caitlin Sedwick Sergio Grinstein: Phagocytosis step by
step . . . . . . . . . . . . . . . . . . 392
Pengfei Lu and
Valerie M. Weaver and
Zena Werb The extracellular matrix: a dynamic
niche in cancer progression . . . . . . 395
Sandra Maday and
Karen E. Wallace and
Erika L. F. Holzbaur Autophagosomes initiate distally and
mature during transport toward the cell
soma in primary neurons . . . . . . . . 407
Javier Fernandez-Martinez and
Jeremy Phillips and
Matthew D. Sekedat and
Ruben Diaz-Avalos and
Javier Velazquez-Muriel and
Josef D. Franke and
Rosemary Williams and
David L. Stokes and
Brian T. Chait and
Andrej Sali and
Michael P. Rout Structure--function mapping of a
heptameric module in the nuclear pore
complex . . . . . . . . . . . . . . . . 419
Emanuele Roscioli and
Laura Di Francesco and
Alessio Bolognesi and
Maria Giubettini and
Serena Orlando and
Amnon Harel and
Maria Eugenia Schinin\`a and
Patrizia Lavia Importin-$ \beta $ negatively regulates
multiple aspects of mitosis including
RANGAP1 recruitment to kinetochores . . 435
Veronica Krenn and
Annemarie Wehenkel and
Xiaozheng Li and
Stefano Santaguida and
Andrea Musacchio Structural analysis reveals features of
the spindle checkpoint kinase
Bub1--kinetochore subunit Knl1
interaction . . . . . . . . . . . . . . 451
Julien Espeut and
Dhanya K. Cheerambathur and
Lenno Krenning and
Karen Oegema and
Arshad Desai Microtubule binding by KNL-1 contributes
to spindle checkpoint silencing at the
kinetochore . . . . . . . . . . . . . . 469
Kevin Moreau and
Brinda Ravikumar and
Claudia Puri and
David C. Rubinsztein Arf6 promotes autophagosome formation
via effects on phosphatidylinositol
4,5-bisphosphate and phospholipase D . . 483
Nadine Bakkar and
Katherine Ladner and
Benjamin D. Canan and
Sandya Liyanarachchi and
Naresh C. Bal and
Meghna Pant and
Muthu Periasamy and
Qiutang Li and
Paul M. L. Janssen and
Denis C. Guttridge IKK$ \alpha $ and alternative NF-$
\kappa $B regulate PGC-1$ \beta $ to
promote oxidative muscle metabolism . . 497
Anat Florentin and
Eli Arama Caspase levels and execution
efficiencies determine the apoptotic
potential of the cell . . . . . . . . . 513
Xu Chen and
Barry Ganetzky A neuropeptide signaling pathway
regulates synaptic growth in
\bionameDrosophila . . . . . . . . . . . 529
Ana Maria Rojas and
Gloria Fuentes and
Antonio Rausell and
Alfonso Valencia The Ras protein superfamily:
Evolutionary tree and role of conserved
amino acids . . . . . . . . . . . . . . 545
Mitch Leslie Aurora B is no Ska fan . . . . . . . . . ??
Mitch Leslie Vinculin minds the gap . . . . . . . . . ??
Mitch Leslie As the sperm turns . . . . . . . . . . . ??
Mitch Leslie Fly wing cells choose sides . . . . . . 549
Caitlin Sedwick Orna Cohen--Fix: Playing with nuclear
morphology . . . . . . . . . . . . . . . 550
Ryan S. King and
Phillip A. Newmark The cell biology of regeneration . . . . 553
Ying Wai Chan and
A. Arockia Jeyaprakash and
Erich A. Nigg and
Anna Santamaria Aurora B controls
kinetochore--microtubule attachments by
inhibiting Ska complex--KMN network
interaction . . . . . . . . . . . . . . 563
Mark S. Hipp and
Chetan N. Patel and
Kirill Bersuker and
Brigit E. Riley and
Stephen E. Kaiser and
Thomas A. Shaler and
Michael Brandeis and
Ron R. Kopito Indirect inhibition of 26S proteasome
activity in a cellular model of
Huntington's disease . . . . . . . . . . 573
Megan Gervasi and
Anna Bianchi-Smiraglia and
Michael Cummings and
Qiao Zheng and
Dan Wang and
Song Liu and
Andrei V. Bakin JunB contributes to Id2 repression and
the epithelial--mesenchymal transition
in response to transforming growth
factor--$ \beta $ . . . . . . . . . . . 589
William J. Gault and
Patricio Olguin and
Ursula Weber and
Marek Mlodzik Drosophila CK1-$ \gamma $, gilgamesh,
controls PCP-mediated morphogenesis
through regulation of vesicle
trafficking . . . . . . . . . . . . . . 605
Sandra Iden and
Steve Misselwitz and
Swetha S. D. Peddibhotla and
Hüseyin Tuncay and
Daniela Rehder and
Volker Gerke and
Horst Robenek and
Atsushi Suzuki and
Klaus Ebnet aPKC phosphorylates JAM--A at Ser285 to
promote cell contact maturation and
tight junction formation . . . . . . . . 623
Stephan Huveneers and
Joppe Oldenburg and
Emma Spanjaard and
Gerard van der Krogt and
Ilya Grigoriev and
Anna Akhmanova and
Holger Rehmann and
Johan de Rooij Vinculin associates with endothelial
VE-cadherin junctions to control
force-dependent remodeling . . . . . . . 641
Luis Alvarez and
Luru Dai and
Benjamin M. Friedrich and
Nachiket D. Kashikar and
Ingo Gregor and
René Pascal and
U. Benjamin Kaupp The rate of change in Ca$^{2+}$
concentration controls sperm chemotaxis 653
Ben Short ER stress PERKs up an miRNA . . . . . . ??
Ben Short Simulating segregation . . . . . . . . . ??
Ben Short Meet the neighbors . . . . . . . . . . . ??
Ben Short Directing a chaperone . . . . . . . . . 667
Caitlin Sedwick Sue Biggins: How kinetochores keep
control of mitosis . . . . . . . . . . . 668
Richard O. Hynes The evolution of metazoan extracellular
matrix . . . . . . . . . . . . . . . . . 671
Steven Bergink and
Wendy Toussaint and
Martijn S. Luijsterburg and
Christoffel Dinant and
Sergey Alekseev and
Jan H. J. Hoeijmakers and
Nico P. Dantuma and
Adriaan B. Houtsmuller and
Wim Vermeulen Recognition of DNA damage by XPC
coincides with disruption of the
XPC--RAD23 complex . . . . . . . . . . . 681
Andrew E. Byrd and
Ileana V. Aragon and
Joseph W. Brewer MicroRNA-30c-2* limits expression of
proadaptive factor XBP1 in the unfolded
protein response . . . . . . . . . . . . 689
Aymeric Ravel-Chapuis and
Guy Bélanger and
Ramesh S. Yadava and
Mani S. Mahadevan and
Luc DesGroseillers and
Jocelyn Côté and
Bernard J. Jasmin The RNA-binding protein Staufen1 is
increased in DM1 skeletal muscle and
promotes alternative pre-mRNA splicing 699
Sunghwan Kim and
Dionisia P. Sideris and
Carolyn S. Sevier and
Chris A. Kaiser Balanced Ero1 activation and
inactivation establishes ER redox
homeostasis . . . . . . . . . . . . . . 713
Scott D. Ryan and
Kunal Bhanot and
Andrew Ferrier and
Yves De Repentigny and
Alphonse Chu and
Alexandre Blais and
Rashmi Kothary Microtubule stability, Golgi
organization, and transport flux require
dystonin-a2--MAP1B interaction . . . . . 727
Xianying Tang and
Bryan St. Germain and
Wei-Lih Lee A novel patch assembly domain in Num1
mediates dynein anchoring at the cortex
during spindle positioning . . . . . . . 743
Guillaume Gay and
Thibault Courtheoux and
Céline Reyes and
Sylvie Tournier and
Yannick Gachet A stochastic model of
kinetochore--microtubule attachment
accurately describes fission yeast
chromosome segregation . . . . . . . . . 757
Sandra Dieni and
Tomoya Matsumoto and
Martijn Dekkers and
Stefanie Rauskolb and
Mihai S. Ionescu and
Ruben Deogracias and
Eckart D. Gundelfinger and
Masami Kojima and
Sigrun Nestel and
Michael Frotscher and
Yves-Alain Barde BDNF and its pro-peptide are stored in
presynaptic dense core vesicles in brain
neurons . . . . . . . . . . . . . . . . 775
Anjali A. Sarkar and
Irene E. Zohn Hectd1 regulates intracellular
localization and secretion of Hsp90 to
control cellular behavior of the cranial
mesenchyme . . . . . . . . . . . . . . . 789
Kyle J. Roux and
Dae In Kim and
Manfred Raida and
Brian Burke A promiscuous biotin ligase fusion
protein identifies proximal and
interacting proteins in mammalian cells 801
Ben Short Ovastacin cuts off sperm binding . . . . ??
Ben Short $ \gamma $-Tubulin stands up to be
counted . . . . . . . . . . . . . . . . ??
Ben Short Leukocytes drop anchor . . . . . . . . . ??
Ben Short Big enough for two . . . . . . . . . . . 3
Caitlin Sedwick Ewald Weibel: an organelle of his very
own, and more . . . . . . . . . . . . . 4
David W. Reid and
Christopher V. Nicchitta The enduring enigma of nuclear
translation . . . . . . . . . . . . . . 7
Balca R. Mardin and
Elmar Schiebel Breaking the ties that bind: New
advances in centrosome biology . . . . . 11
David Reboutier and
Marie-Béreng\`ere Troadec and
Jean-Yves Cremet and
Kenji Fukasawa and
Claude Prigent Nucleophosmin\slash B23 activates Aurora
A at the centrosome through
phosphorylation of serine 89 . . . . . . 19
Wei Li and
Wei Zou and
Yihong Yang and
Yongping Chai and
Baohui Chen and
Shiya Cheng and
Dong Tian and
Xiaochen Wang and
Ronald D. Vale and
Guangshuo Ou Autophagy genes function sequentially to
promote apoptotic cell corpse
degradation in the engulfing cell . . . 27
Anna D. Burkart and
Bo Xiong and
Boris Baibakov and
Maria Jiménez-Movilla and
Jurrien Dean Ovastacin, a cortical granule protease,
cleaves ZP2 in the zona pellucida to
prevent polyspermy . . . . . . . . . . . 37
Alexandre David and
Brian P. Dolan and
Heather D. Hickman and
Jonathan J. Knowlton and
Giovanna Clavarino and
Philippe Pierre and
Jack R. Bennink and
Jonathan W. Yewdell Nuclear translation visualized by
ribosome-bound nascent chain
puromycylation . . . . . . . . . . . . . 45
Sarah Erlemann and
Annett Neuner and
Linda Gombos and
Romain Gibeaux and
Claude Antony and
Elmar Schiebel An extended $ \gamma $-tubulin ring
functions as a stable platform in
microtubule nucleation . . . . . . . . . 59
Andrea K. H. Stavoe and
Daniel A. Colón-Ramos Netrin instructs synaptic vesicle
clustering through Rac GTPase, MIG-10,
and the actin cytoskeleton . . . . . . . 75
Steph D. Anastasia and
Duy Linh Nguyen and
Vu Thai and
Melissa Meloy and
Tracy MacDonough and
Douglas R. Kellogg A link between mitotic entry and
membrane growth suggests a novel model
for cell size control . . . . . . . . . 89
Erik S. Welf and
Shoeb Ahmed and
Heath E. Johnson and
Adam T. Melvin and
Jason M. Haugh Migrating fibroblasts reorient
directionality by a metastable,
PI3K-dependent mechanism . . . . . . . . 105
Jacob Rullo and
Henry Becker and
Sharon J. Hyduk and
Janice C. Wong and
Genevieve Digby and
Pamma D. Arora and
Adrianet Puig Cano and
John Hartwig and
Christopher A. McCulloch and
Myron I. Cybulsky Actin polymerization stabilizes $ \alpha
$4$ \beta $1 integrin anchors that
mediate monocyte adhesion . . . . . . . 115
Masamichi Nagae and
Suyong Re and
Emiko Mihara and
Terukazu Nogi and
Yuji Sugita and
Junichi Takagi Crystal structure of $ \alpha $5$ \beta
$1 integrin ectodomain: Atomic details
of the fibronectin receptor . . . . . . 131
Georg H. H. Borner and
Robin Antrobus and
Jennifer Hirst and
Gary S. Bhumbra and
Patrycja Kozik and
Lauren P. Jackson and
Daniela A. Sahlender and
Margaret S. Robinson Multivariate proteomic profiling
identifies novel accessory proteins of
coated vesicles . . . . . . . . . . . . 141
Mitch Leslie RNF169 flips the repair switch . . . . . ??
Mitch Leslie BRCA1 touches up microRNAs . . . . . . . ??
Mitch Leslie Wait, save that integrin! . . . . . . . ??
Mitch Leslie Playing with Arp2/3 uncovers cellular
rudder . . . . . . . . . . . . . . . . . 163
Caitlin Sedwick Yoshinori Ohsumi: Autophagy from
beginning to end . . . . . . . . . . . . 164
Harry T. Orr Cell biology of spinocerebellar ataxia 167
Jannie Rendtlew Danielsen and
Lou Klitgaard Povlsen and
Bine Hare Villumsen and
Werner Streicher and
Jakob Nilsson and
Mats Wikström and
Simon Bekker-Jensen and
Niels Mailand DNA damage--inducible SUMOylation of
HERC2 promotes RNF8 binding via a novel
SUMO-binding Zinc finger . . . . . . . . 179
Maria Poulsen and
Claudia Lukas and
Jiri Lukas and
Simon Bekker-Jensen and
Niels Mailand Human RNF169 is a negative regulator of
the ubiquitin-dependent response to DNA
double-strand breaks . . . . . . . . . . 189
Shinji Kawai and
Atsuo Amano BRCA1 regulates microRNA biogenesis via
the DROSHA microprocessor complex . . . 201
Kamran Anwar and
Robin W. Klemm and
Amanda Condon and
Katharina N. Severin and
Miao Zhang and
Rodolfo Ghirlando and
Junjie Hu and
Tom A. Rapoport and
William A. Prinz The dynamin-like GTPase Sey1p mediates
homotypic ER fusion in S. cerevisiae . . 209
Florian Steinberg and
Kate J. Heesom and
Mark D. Bass and
Peter J. Cullen SNX17 protects integrins from
degradation by sorting between lysosomal
and recycling pathways . . . . . . . . . 219
Sarah B. Domnitz and
Michael Wagenbach and
Justin Decarreau and
Linda Wordeman MCAK activity at microtubule tips
regulates spindle microtubule length to
promote robust kinetochore attachment 231
Praveen Suraneni and
Boris Rubinstein and
Jay R. Unruh and
Michael Durnin and
Dorit Hanein and
Rong Li The Arp2/3 complex is required for
lamellipodia extension and directional
fibroblast cell migration . . . . . . . 239
William C. Drosopoulos and
Settapong T. Kosiyatrakul and
Zi Yan and
Simone G. Calderano and
Carl L. Schildkraut Human telomeres replicate using
chromosome-specific, rather than
universal, replication programs . . . . 253
Martijn S. Luijsterburg and
Michael Lindh and
Klara Acs and
Mischa G. Vrouwe and
Alex Pines and
Haico van Attikum and
Leon H. Mullenders and
Nico P. Dantuma DDB2 promotes chromatin decondensation
at UV-induced DNA damage . . . . . . . . 267
Paula Martínez and
Juana M. Flores and
Maria A. Blasco 53BP1 deficiency combined with telomere
dysfunction activates ATR-dependent DNA
damage response . . . . . . . . . . . . 283
Kristin L. Boswell and
Declan J. James and
Joseph M. Esquibel and
Stephen Bruinsma and
Ryutaro Shirakawa and
Hisanori Horiuchi and
Thomas F. J. Martin Munc13-4 reconstitutes calcium-dependent
SNARE-mediated membrane fusion . . . . . 301
Camille Enjolras and
Joëlle Thomas and
Brigitte Chhin and
Elisabeth Cortier and
Jean-Luc Duteyrat and
Fabien Soulavie and
Maurice J. Kernan and
Anne Laurençon and
Bénédicte Durand Drosophila chibby is required for basal
body formation and ciliogenesis but not
for Wg signaling . . . . . . . . . . . . 313
Arthur P. H. de Jong and
Sabine K. Schmitz and
Ruud F. G. Toonen and
Matthijs Verhage Dendritic position is a major
determinant of presynaptic strength . . 327
Ben Short The APC/C gets Trim'd down for apoptosis ??
Ben Short Prion puts yeast cells under arrest . . ??
Ben Short Ubiquitin isn't ubiquitous in receptor
trafficking . . . . . . . . . . . . . . ??
Ben Short Trichoplein keeps primary cilia silent 341
Caitlin Sedwick Coleen Murphy: How to stay young at
heart, body, and mind . . . . . . . . . 342
Elizabeth H. Williams and
Pamela A. Carpentier and
Tom Misteli Minimizing the ``Re'' in Review . . . . 345
Michael Sixt Cell migration: Fibroblasts find a new
way to get ahead . . . . . . . . . . . . 347
Deok-Ho Kim and
Paolo P. Provenzano and
Chris L. Smith and
Andre Levchenko Matrix nanotopography as a regulator of
cell function . . . . . . . . . . . . . 351
Nai-Jia Huang and
Liguo Zhang and
Wanli Tang and
Chen Chen and
Chih-Sheng Yang and
Sally Kornbluth The Trim39 ubiquitin ligase inhibits
APC/C$^{\rm Cdh1}$-mediated degradation
of the Bax activator MOAP-1 . . . . . . 361
Sebastian Treusch and
Susan Lindquist An intrinsically disordered yeast prion
arrests the cell cycle by sequestering a
spindle pole body component . . . . . . 369
Jeremy D. Rotty and
Pierre A. Coulombe A wound-induced keratin inhibits Src
activity during keratinocyte migration
and tissue repair . . . . . . . . . . . 381
Akihito Inoko and
Makoto Matsuyama and
Hidemasa Goto and
Yuki Ohmuro-Matsuyama and
Yuko Hayashi and
Masato Enomoto and
Miho Ibi and
Takeshi Urano and
Shigenobu Yonemura and
Tohru Kiyono and
Ichiro Izawa and
Masaki Inagaki Trichoplein and Aurora A block aberrant
primary cilia assembly in proliferating
cells . . . . . . . . . . . . . . . . . 391
Michael R. Dores and
Buxin Chen and
Huilan Lin and
Unice J. K. Soh and
May M. Paing and
William A. Montagne and
Timo Meerloo and
JoAnn Trejo ALIX binds a YPX$_3$ L motif of the GPCR
PAR1 and mediates ubiquitin-independent
ESCRT-III/MVB sorting . . . . . . . . . 407
Jeanine Pignatelli and
David A. Tumbarello and
Ronald P. Schmidt and
Christopher E. Turner Hic-5 promotes invadopodia formation and
invasion during TGF-$ \beta $-induced
epithelial--mesenchymal transition . . . 421
Ryan J. Petrie and
Núria Gavara and
Richard S. Chadwick and
Kenneth M. Yamada Nonpolarized signaling reveals two
distinct modes of $3$D cell migration 439
Arun Anantharam and
Bibiana Onoa and
Robert H. Edwards and
Ronald W. Holz and
Daniel Axelrod Localized topological changes of the
plasma membrane upon exocytosis
visualized by polarized TIRFM . . . . . 457
Ben Short Mitochondrial morphology shapes
differentiation . . . . . . . . . . . . ??
Ben Short Putting a ``cap'' on clathrin-mediated
endocytosis . . . . . . . . . . . . . . ??
Ben Short Protrusion drives osteoclast fusion . . ??
Ben Short miR-34s keep osteoblasts bone idle . . . 461
Caitlin Sedwick Fernando Camargo: No limits to learning
about stem cells . . . . . . . . . . . . 462
Kathleen C. Suozzi and
Xiaoyang Wu and
Elaine Fuchs Spectraplakins: Master orchestrators of
cytoskeletal dynamics . . . . . . . . . 465
Jennifer Zanet and
Asier Jayo and
Serge Plaza and
Tom Millard and
Maddy Parsons and
Brian Stramer Fascin promotes filopodia formation
independent of its role in actin
bundling . . . . . . . . . . . . . . . . 477
Kasturi Mitra and
Richa Rikhy and
Mary Lilly and
Jennifer Lippincott-Schwartz DRP1-dependent mitochondrial fission
initiates follicle cell differentiation
during \bionameDrosophila oogenesis . . 487
Andrew I. Shevchuk and
Pavel Novak and
Marcus Taylor and
Ivan A. Diakonov and
Azza Ziyadeh-Isleem and
Marc Bitoun and
Pascale Guicheney and
Max J. Lab and
Julia Gorelik and
Christien J. Merrifield and
David Klenerman and
Yuri E. Korchev An alternative mechanism of
clathrin-coated pit closure revealed by
ion conductance microscopy . . . . . . . 499
Jianwen Wei and
Yu Shi and
Lihua Zheng and
Bin Zhou and
Hiroyuki Inose and
Ji Wang and
X. Edward Guo and
Rudolf Grosschedl and
Gerard Karsenty miR-34s inhibit osteoblast proliferation
and differentiation in the mouse by
targeting SATB2 . . . . . . . . . . . . 509
Jose M. Celedon and
Kenneth Cline Stoichiometry for binding and transport
by the twin arginine translocation
system . . . . . . . . . . . . . . . . . 523
Yusuke Kageyama and
Zhongyan Zhang and
Ricardo Roda and
Masahiro Fukaya and
Junko Wakabayashi and
Nobunao Wakabayashi and
Thomas W. Kensler and
P. Hemachandra Reddy and
Miho Iijima and
Hiromi Sesaki Mitochondrial division ensures the
survival of postmitotic neurons by
suppressing oxidative damage . . . . . . 535
Tsukasa Oikawa and
Masaaki Oyama and
Hiroko Kozuka-Hata and
Shunsuke Uehara and
Nobuyuki Udagawa and
Hideyuki Saya and
Koichi Matsuo Tks5-dependent formation of
circumferential podosomes/invadopodia
mediates cell--cell fusion . . . . . . . 553
Mitch Leslie Talin gives integrins a nudge . . . . . ??
Mitch Leslie Recycling endosomes feed autophagy . . . ??
Mitch Leslie Unfinished basement membrane spurs
developmental disorder . . . . . . . . . ??
Mitch Leslie Nck by the numbers . . . . . . . . . . . 571
Caitlin Sedwick Graça Raposo: Melanosomes, more than skin
deep . . . . . . . . . . . . . . . . . . 572
Alexandra Van Keymeulen and
Cédric Blanpain Tracing epithelial stem cells during
development, homeostasis, and repair . . 575
Mandy E. W. Janssen and
HongJun Liu and
Niels Volkmann and
Dorit Hanein The C-terminal tail domain of
metavinculin, vinculin's splice variant,
severs actin filaments . . . . . . . . . 585
Michael Gebert and
Sandra G. Schrempp and
Carola S. Mehnert and
Anna K. Heißwolf and
Silke Oeljeklaus and
Raffaele Ieva and
Maria Bohnert and
Karina von der Malsburg and
Sebastian Wiese and
Thomas Kleinschroth and
Carola Hunte and
Helmut E. Meyer and
Ilka Haferkamp and
Bernard Guiard and
Bettina Warscheid and
Nikolaus Pfanner and
Martin van der Laan Mgr2 promotes coupling of the
mitochondrial presequence translocase to
partner complexes . . . . . . . . . . . 595
Chungho Kim and
Feng Ye and
Xiaohui Hu and
Mark H. Ginsberg Talin activates integrins by altering
the topology of the $ \beta $
transmembrane domain . . . . . . . . . . 605
Joseph K. Hsu and
Tao Lin and
Robert Y. L. Tsai Nucleostemin prevents telomere damage by
promoting PML--IV recruitment to
SUMOylated TRF1 . . . . . . . . . . . . 613
Tatsuyuki Chiyoda and
Naoyuki Sugiyama and
Takatsune Shimizu and
Hideaki Naoe and
Yusuke Kobayashi and
Jo Ishizawa and
Yoshimi Arima and
Hiroshi Tsuda and
Masaaki Ito and
Kozo Kaibuchi and
Daisuke Aoki and
Yasushi Ishihama and
Hideyuki Saya and
Shinji Kuninaka LATS1\slash WARTS phosphorylates MYPT1
to counteract PLK1 and regulate
mammalian mitotic progression . . . . . 625
Jonathon A. Ditlev and
Paul J. Michalski and
Greg Huber and
Gonzalo M. Rivera and
William A. Mohler and
Leslie M. Loew and
Bruce J. Mayer Stoichiometry of Nck-dependent actin
polymerization in living cells . . . . . 643
Andrea Longatti and
Christopher A. Lamb and
Minoo Razi and
Shin-ichiro Yoshimura and
Francis A. Barr and
Sharon A. Tooze TBC1D14 regulates autophagosome
formation via Rab11- and ULK1-positive
recycling endosomes . . . . . . . . . . 659
Daiji Kiyozumi and
Makiko Takeichi and
Itsuko Nakano and
Yuya Sato and
Tomohiko Fukuda and
Kiyotoshi Sekiguchi Basement membrane assembly of the
integrin $ \alpha $8$ \beta $1 ligand
nephronectin requires Fraser
syndrome--associated proteins . . . . . 677
Ben Short Protrusion provides a prognosis . . . . ??
Ben Short The ribosome runs a systems test . . . . ??
Ben Short IFT-A goes both ways . . . . . . . . . . ??
Ben Short Talin is cut out for intercellular
adhesion . . . . . . . . . . . . . . . . 693
Caitlin Sedwick Alexey Khodjakov: Diving into the
mitotic apparatus . . . . . . . . . . . 694
Francesc R. Garcia-Gonzalo and
Jeremy F. Reiter Scoring a backstage pass: Mechanisms of
ciliogenesis and ciliary access . . . . 697
Cesare Orlandi and
Ekaterina Posokhova and
Ikuo Masuho and
Thomas A. Ray and
Nazarul Hasan and
Ronald G. Gregg and
Kirill A. Martemyanov GPR158\slash 179 regulate G protein
signaling by controlling localization
and activity of the RGS7 complexes . . . 711
Aaron S. Meyer and
Shannon K. Hughes-Alford and
Jennifer E. Kay and
Amalchi Castillo and
Alan Wells and
Frank B. Gertler and
Douglas A. Lauffenburger 2D protrusion but not motility predicts
growth factor--induced cancer cell
migration in $3$D collagen . . . . . . . 721
Jian Qu and
J. Michael Bishop Nucleostemin maintains self-renewal of
embryonic stem cells and promotes
reprogramming of somatic cells to
pluripotency . . . . . . . . . . . . . . 731
Cyril Bussiere and
Yaser Hashem and
Sucheta Arora and
Joachim Frank and
Arlen W. Johnson Integrity of the P-site is probed during
maturation of the 60S ribosomal subunit 747
Eric M. Rubenstein and
Stefan G. Kreft and
Wesley Greenblatt and
Robert Swanson and
Mark Hochstrasser Aberrant substrate engagement of the ER
translocon triggers degradation by the
Hrd1 ubiquitin ligase . . . . . . . . . 761
Alexander Babich and
Shuixing Li and
Roddy S. O'Connor and
Michael C. Milone and
Bruce D. Freedman and
Janis K. Burkhardt F-actin polymerization and retrograde
flow drive sustained PLC$ \gamma $1
signaling during T cell activation . . . 775
Karel F. Liem and
Alyson Ashe and
Mu He and
Peter Satir and
Jennifer Moran and
David Beier and
Carol Wicking and
Kathryn V. Anderson The IFT--A complex regulates Shh
signaling through cilia structure and
membrane protein trafficking . . . . . . 789
Athina-Myrto Chioni and
Richard Grose FGFR1 cleavage and nuclear translocation
regulates breast cancer cell behavior 801
Fangliang Zhang and
Sougata Saha and
Anna Kashina Arginylation-dependent regulation of a
proteolytic product of talin is
essential for cell--cell adhesion . . . 819
Sophie Lutter and
Sherry Xie and
Florence Tatin and
Taija Makinen Smooth muscle--endothelial cell
communication activates Reelin signaling
and regulates lymphatic vessel formation 837
Mitch Leslie Cohesin sticks to it during meiosis . . ??
Mitch Leslie Why yeast mothers and daughters don't
share . . . . . . . . . . . . . . . . . ??
Mitch Leslie Lis1 cuts its work short . . . . . . . . ??
Mitch Leslie Asters push embryonic nuclei to the
brink . . . . . . . . . . . . . . . . . 853
Caitlin Sedwick Markus Grebe: Bringing plant polarity to
light . . . . . . . . . . . . . . . . . 854
Shiyu Wang and
Randal J. Kaufman The impact of the unfolded protein
response on human disease . . . . . . . 857
Arne Nedergaard Kousholt and
Kasper Fugger and
Saskia Hoffmann and
Brian D. Larsen and
Tobias Menzel and
Alessandro A. Sartori and
Claus Storgaard Sòrensen CtIP-dependent DNA resection is required
for DNA damage checkpoint maintenance
but not initiation . . . . . . . . . . . 869
Elena Llano and
Yurema Herrán and
Ignacio García-Tuñón and
Cristina Gutiérrez-Caballero and
Enrique de Álava and
José Luis Barbero and
John Schimenti and
Dirk G. de Rooij and
Manuel Sánchez-Martín and
Alberto M. Pendás Meiotic cohesin complexes are essential
for the formation of the axial element
in mice . . . . . . . . . . . . . . . . 877
Ivo A. Telley and
Imre Gáspár and
Anne Ephrussi and
Thomas Surrey Aster migration determines the length
scale of nuclear separation in the
\bionameDrosophila syncytial embryo . . 887
Boris Baibakov and
Nathan A. Boggs and
Belinda Yauger and
Galina Baibakov and
Jurrien Dean Human sperm bind to the N-terminal
domain of ZP2 in humanized zonae
pellucidae in transgenic mice . . . . . 897
Ssang-Taek Lim and
Nichol L. G. Miller and
Xiao Lei Chen and
Isabelle Tancioni and
Colin T. Walsh and
Christine Lawson and
Sean Uryu and
Sara M. Weis and
David A. Cheresh and
David D. Schlaepfer Nuclear-localized focal adhesion kinase
regulates inflammatory VCAM-1 expression 907
Barbara Boettcher and
Tatiana T. Marquez-Lago and
Mathias Bayer and
Eric L. Weiss and
Yves Barral Nuclear envelope morphology constrains
diffusion and promotes asymmetric
protein segregation in closed mitosis 921
Qing Yang and
Xiao-Feng Zhang and
Thomas D. Pollard and
Paul Forscher Arp2\slash 3 complex-dependent actin
networks constrain myosin II function in
driving retrograde actin flow . . . . . 939
Katherine C. Rank and
Chun Ju Chen and
Julia Cope and
Ken Porche and
Andreas Hoenger and
Susan P. Gilbert and
Ivan Rayment Kar3Vik1, a member of the Kinesin-14
superfamily, shows a novel kinesin
microtubule binding pattern . . . . . . 957
Martin J. Egan and
Kaeling Tan and
Samara L. Reck-Peterson Lis1 is an initiation factor for
dynein-driven organelle transport . . . 971
Yasuhito Onodera and
Jin-Min Nam and
Ari Hashimoto and
Jim C. Norman and
Hiroki Shirato and
Shigeru Hashimoto and
Hisataka Sabe Rab5c promotes AMAP1--PRKD2 complex
formation to enhance $ \beta $1 integrin
recycling in EGF-induced cancer invasion 983
Catherine E. Winbanks and
Kate L. Weeks and
Rachel E. Thomson and
Patricio V. Sepulveda and
Claudia Beyer and
Hongwei Qian and
Justin L. Chen and
James M. Allen and
Graeme I. Lancaster and
Mark A. Febbraio and
Craig A. Harrison and
Julie R. McMullen and
Jeffrey S. Chamberlain and
Paul Gregorevic Follistatin-mediated skeletal muscle
hypertrophy is regulated by Smad3 and
mTOR independently of myostatin . . . . 997
Jamie L. Marshall and
Johan Holmberg and
Eric Chou and
Amber C. Ocampo and
Jennifer Oh and
Joy Lee and
Angela K. Peter and
Paul T. Martin and
Rachelle H. Crosbie-Watson Sarcospan-dependent Akt activation is
required for utrophin expression and
muscle regeneration . . . . . . . . . . 1009
Steven M. Claypool and
Yavuz Oktay and
Pinmanee Boontheung and
Joseph A. Loo and
Carla M. Koehler Cardiolipin defines the interactome of
the major ADP/ATP carrier protein of the
mitochondrial inner membrane . . . . . . 1029
Ben Short The Fuzzy logistics of intraflagellar
transport . . . . . . . . . . . . . . . ??
Ben Short Organelles compete for their inheritance ??
Ben Short Formin' muscle sarcomeres . . . . . . . ??
Ben Short Schwann cells aid regeneration project 3
Caitlin Sedwick Jiri Lukas: Visualizing genome integrity
maintenance . . . . . . . . . . . . . . 4
Ilya Bezprozvanny Presenilins: a novel link between
intracellular calcium signaling and
lysosomal function? . . . . . . . . . . 7
Hugues de Thé and
Morgane Le Bras and
Valérie Lallemand-Breitenbach Acute promyelocytic leukemia, arsenic,
and PML bodies . . . . . . . . . . . . . 11
Katrijn Coen and
Ronald S. Flannagan and
Szilvia Baron and
Luciene R. Carraro-Lacroix and
Dong Wang and
Wendy Vermeire and
Christine Michiels and
Sebastian Munck and
Veerle Baert and
Shuzo Sugita and
Frank Wuytack and
Peter Robin Hiesinger and
Sergio Grinstein and
Wim Annaert Lysosomal calcium homeostasis defects,
not proton pump defects, cause
endo-lysosomal dysfunction in
PSEN-deficient cells . . . . . . . . . . 23
Eric R. Brooks and
John B. Wallingford Control of vertebrate intraflagellar
transport by the planar cell polarity
effector Fuz . . . . . . . . . . . . . . 37
Yi Fan and
Sandeepa M. Eswarappa and
Masahiro Hitomi and
Paul L. Fox Myo1c facilitates G-actin transport to
the leading edge of migrating
endothelial cells . . . . . . . . . . . 47
Carl Laflamme and
Gloria Assaker and
Damien Ramel and
Jonas F. Dorn and
Desmond She and
Paul S. Maddox and
Gregory Emery Evi5 promotes collective cell migration
through its Rab--GAP activity . . . . . 57
P. Taylor Eves and
Yui Jin and
Matthew Brunner and
Lois S. Weisman Overlap of cargo binding sites on myosin
V coordinates the inheritance of diverse
cargoes . . . . . . . . . . . . . . . . 69
Lei Mi-Mi and
SarahBeth Votra and
Kenneth Kemphues and
Anthony Bretscher and
David Pruyne Z-line formins promote contractile
lattice growth and maintenance in
striated muscles of \bionameC. elegans 87
Yanmei Qi and
Xiaoxiang Tian and
Jie Liu and
Yaling Han and
Alan M. Graham and
M. Celeste Simon and
Josef M. Penninger and
Peter Carmeliet and
Shaohua Li Bnip3 and AIF cooperate to induce
apoptosis and cavitation during
epithelial morphogenesis . . . . . . . . 103
Anjali Gupta and
Dennis R. Diener and
Priyanka Sivadas and
Joel L. Rosenbaum and
Pinfen Yang The versatile molecular complex
component LC8 promotes several distinct
steps of flagellar assembly . . . . . . 115
Xavier Fontana and
Mariya Hristova and
Clive Da Costa and
Smriti Patodia and
Laura Thei and
Milan Makwana and
Bradley Spencer-Dene and
Morwena Latouche and
Rhona Mirsky and
Kristjan R. Jessen and
Rüdiger Klein and
Gennadij Raivich and
Axel Behrens c-Jun in Schwann cells promotes axonal
regeneration and motoneuron survival via
paracrine signaling . . . . . . . . . . 127
Barbara Boettcher and
Tatiana T. Marquez-Lago and
Mathias Bayer and
Eric L. Weiss and
Yves Barral Nuclear envelope morphology constrains
diffusion and promotes asymmetric
protein segregation in closed mitosis 143
Ben Short Sds22 and Repo--Man keep anaphase
chromosomes moving . . . . . . . . . . . ??
Ben Short Microvillar scaffold is only temporary ??
Ben Short BubR1 shows self-control . . . . . . . . ??
Ben Short PI(3,5)P$_2$ sows the seeds of plant
growth . . . . . . . . . . . . . . . . . 147
Caitlin Sedwick Karen Vousden: Getting the big picture
on p53 . . . . . . . . . . . . . . . . . 148
Fulvio Reggiori and
Sharon A. Tooze Autophagy regulation through Atg9
traffic . . . . . . . . . . . . . . . . 151
Yue Xiong and
Kun-Liang Guan Mechanistic insights into the regulation
of metabolic enzymes by acetylation . . 155
Akihiro Morimoto and
Hiroki Shibuya and
Xiaoqiang Zhu and
Jihye Kim and
Kei-ichiro Ishiguro and
Min Han and
Yoshinori Watanabe A conserved KASH domain protein
associates with telomeres, SUN1, and
dynactin during mammalian meiosis . . . 165
Claudia Wurzenberger and
Michael Held and
Michael A. Lampson and
Ina Poser and
Anthony A. Hyman and
Daniel W. Gerlich Sds22 and Repo--Man stabilize chromosome
segregation by counteracting Aurora B on
anaphase kinetochores . . . . . . . . . 173
Kirti Magudia and
Aurelia Lahoz and
Alan Hall K-Ras and B--Raf oncogenes inhibit colon
epithelial polarity establishment
through up-regulation of c-myc . . . . . 185
Damien Garbett and
Anthony Bretscher PDZ interactions regulate rapid turnover
of the scaffolding protein EBP50 in
microvilli . . . . . . . . . . . . . . . 195
Yige Guo and
Christine Kim and
Sana Ahmad and
Jiayin Zhang and
Yinghui Mao CENP-E-dependent BubR1
autophosphorylation enhances chromosome
alignment and the mitotic checkpoint . . 205
Hayashi Yamamoto and
Soichiro Kakuta and
Tomonobu M. Watanabe and
Akira Kitamura and
Takayuki Sekito and
Chika Kondo-Kakuta and
Rie Ichikawa and
Masataka Kinjo and
Yoshinori Ohsumi Atg9 vesicles are an important membrane
source during early steps of
autophagosome formation . . . . . . . . 219
Peter A. C. van Gisbergen and
Ming Li and
Shu-Zon Wu and
Magdalena Bezanilla Class II formin targeting to the cell
cortex by binding PI(3,5)P$_2$ is
essential for polarized growth . . . . . 235
Enora Moutin and
Fabrice Raynaud and
Jonathan Roger and
Emilie Pellegrino and
Vincent Homburger and
Federica Bertaso and
Vincent Ollendorff and
Joël Bockaert and
Laurent Fagni and
Julie Perroy Dynamic remodeling of scaffold
interactions in dendritic spines
controls synaptic excitability . . . . . 251
Mitch Leslie Fungal pores feel the pull . . . . . . . ??
Mitch Leslie Chaperones team up twice . . . . . . . . ??
Mitch Leslie CLASPing microtubules to the membrane ??
Mitch Leslie Outgrowing meiosis . . . . . . . . . . . 267
Caitlin Sedwick Barry Thompson: The delicate
choreography in growing epithelia . . . 268
Elizabeth H. Williams and
Pamela Carpentier and
Tom Misteli The JCB DataViewer scales up . . . . . . 271
Yosef Shiloh and
Yael Ziv The ATM protein: The importance of being
active . . . . . . . . . . . . . . . . . 273
David Pincus and
Peter Walter A first line of defense against ER
stress . . . . . . . . . . . . . . . . . 277
Ir\`ene Baccelli and
Andreas Trumpp The evolving concept of cancer and
metastasis stem cells . . . . . . . . . 281
Jeremy A. Daniel and
Manuela Pellegrini and
Baeck-Seung Lee and
Zhi Guo and
Darius Filsuf and
Natalya V. Belkina and
Zhongsheng You and
Tanya T. Paull and
Barry P. Sleckman and
Lionel Feigenbaum and
André Nussenzweig Loss of ATM kinase activity leads to
embryonic lethality in mice . . . . . . 295
Kenta Yamamoto and
Yunyue Wang and
Wenxia Jiang and
Xiangyu Liu and
Richard L. Dubois and
Chyuan-Sheng Lin and
Thomas Ludwig and
Christopher J. Bakkenist and
Shan Zha Kinase-dead ATM protein causes genomic
instability and early embryonic
lethality in mice . . . . . . . . . . . 305
Hiroaki Yajima and
Toshihiko Ogura and
Ryo Nitta and
Yasushi Okada and
Chikara Sato and
Nobutaka Hirokawa Conformational changes in tubulin in
GMPCPP and GDP-taxol microtubules
observed by cryoelectron microscopy . . 315
Yao Wu and
Yiwen Gu and
Mary K. Morphew and
Jun Yao and
Felix L. Yeh and
Min Dong and
Edwin R. Chapman All three components of the neuronal
SNARE complex contribute to secretory
vesicle docking . . . . . . . . . . . . 323
Julien Bellis and
Isabelle Duluc and
Béatrice Romagnolo and
Christine Perret and
Maree C. Faux and
Denis Dujardin and
Caroline Formstone and
Sally Lightowler and
Robert G. Ramsay and
Jean-Noël Freund and
Jan R. De Mey The tumor suppressor Apc controls planar
cell polarities central to gut
homeostasis . . . . . . . . . . . . . . 331
Gero Steinberg and
Martin Schuster and
Ulrike Theisen and
Sreedhar Kilaru and
Andrew Forge and
Magdalena Martin-Urdiroz Motor-driven motility of fungal nuclear
pores organizes chromosomes and fosters
nucleocytoplasmic transport . . . . . . 343
Aurélien Courtois and
Melina Schuh and
Jan Ellenberg and
Takashi Hiiragi The transition from meiotic to mitotic
spindle assembly is gradual during early
mammalian development . . . . . . . . . 357
Joseph E. Chambers and
Kseniya Petrova and
Giulia Tomba and
Michele Vendruscolo and
David Ron ADP ribosylation adapts an ER chaperone
response to short-term fluctuations in
unfolded protein load . . . . . . . . . 371
Juliane Winkler and
Jens Tyedmers and
Bernd Bukau and
Axel Mogk Hsp70 targets Hsp100 chaperones to
substrates for protein disaggregation
and prion fragmentation . . . . . . . . 387
Karen E. Moreira and
Sebastian Schuck and
Bianca Schrul and
Florian Fröhlich and
James B. Moseley and
Tobias C. Walther and
Peter Walter Seg1 controls eisosome assembly and
shape . . . . . . . . . . . . . . . . . 405
Nadine Schmidt and
Sreya Basu and
Stefan Sladecek and
Sabrina Gatti and
Jeffrey van Haren and
Susan Treves and
Jan Pielage and
Niels Galjart and
Hans Rudolf Brenner Agrin regulates CLASP2-mediated capture
of microtubules at the neuromuscular
junction synaptic membrane . . . . . . . 421
Jonathan C. Reed and
Britta Molter and
Clair D. Geary and
John McNevin and
Julie McElrath and
Samina Giri and
Kevin C. Klein and
Jaisri R. Lingappa HIV-1 Gag co-opts a cellular complex
containing DDX6, a helicase that
facilitates capsid assembly . . . . . . 439
Frank G. A. Faas and
M. Cristina Avramut and
Bernard M. van den Berg and
A. Mieke Mommaas and
Abraham J. Koster and
Raimond B. G. Ravelli Virtual nanoscopy: Generation of
ultra-large high resolution electron
microscopy maps . . . . . . . . . . . . 457
Ben Short WASP takes the sting out of SCAR mutants ??
Ben Short GW220 seals the fate of mRNAs . . . . . ??
Ben Short Centrosomes are PKA's sensitive spot . . ??
Ben Short Clathrin helps maintain the centrosome's
integrity . . . . . . . . . . . . . . . 473
Caitlin Sedwick Bruce Nicklas: Pioneering studies on
spindle forces . . . . . . . . . . . . . 474
Stuart Cane and
Thomas J. Maresca Balancing the kinetochore ledger . . . . 477
Samantha Stehbens and
Torsten Wittmann Targeting and transport: How
microtubules control focal adhesion
dynamics . . . . . . . . . . . . . . . . 481
Dan Liu and
Olga Davydenko and
Michael A. Lampson Polo-like kinase-1 regulates
kinetochore--microtubule dynamics and
spindle checkpoint silencing . . . . . . 491
Douwe M. Veltman and
Jason S. King and
Laura M. Machesky and
Robert H. Insall SCAR knockouts in \bionameDictyostelium:
WASP assumes SCAR's position and
upstream regulators in pseudopods . . . 501
Peer Papior and
José M. Arteaga-Salas and
Thomas Günther and
Adam Grundhoff and
Aloys Schepers Open chromatin structures regulate the
efficiencies of pre--RC formation and
replication initiation in Epstein--Barr
virus . . . . . . . . . . . . . . . . . 509
Virginia Castilla-Llorente and
Lee Spraggon and
Miwako Okamura and
Saif Naseeruddin and
Matthew Adamow and
Sarah Qamar and
Jidong Liu Mammalian GW220/TNGW1 is essential for
the formation of GW/P bodies containing
miRISC . . . . . . . . . . . . . . . . . 529
Yu Chen and
Yan Wang and
Jinzhong Zhang and
Yongqiang Deng and
Li Jiang and
Eli Song and
Xufeng S. Wu and
John A. Hammer and
Tao Xu and
Jennifer Lippincott-Schwartz Rab10 and myosin--Va mediate
insulin-stimulated GLUT4 storage vesicle
translocation in adipocytes . . . . . . 545
Jonathan N. Thon and
Christopher G. Peters and
Kellie R. Machlus and
Rukhsana Aslam and
Jesse Rowley and
Hannah Macleod and
Matthew T. Devine and
Tobias A. Fuchs and
Andrew S. Weyrich and
John W. Semple and
Robert Flaumenhaft and
Joseph E. Italiano T granules in human platelets function
in TLR9 organization and signaling . . . 561
Shenhav Cohen and
Bo Zhai and
Steven P. Gygi and
Alfred L. Goldberg Ubiquitylation by Trim32 causes coupled
loss of desmin, Z-bands, and thin
filaments in muscle atrophy . . . . . . 575
Amy B. Foraker and
Stéphane M. Camus and
Timothy M. Evans and
Sophia R. Majeed and
Chih-Ying Chen and
Sabrina B. Taner and
Ivan R. Corrêa and
Stephen J. Doxsey and
Frances M. Brodsky Clathrin promotes centrosome integrity
in early mitosis through stabilization
of centrosomal ch--TOG . . . . . . . . . 591
Anna Terrin and
Stefania Monterisi and
Alessandra Stangherlin and
Anna Zoccarato and
Andreas Koschinski and
Nicoletta C. Surdo and
Marco Mongillo and
Akira Sawa and
Niove E. Jordanides and
Joanne C. Mountford and
Manuela Zaccolo PKA and PDE4D3 anchoring to AKAP9
provides distinct regulation of cAMP
signals at the centrosome . . . . . . . 607
Taras Makhnevych and
Philip Wong and
Oxana Pogoutse and
Franco J. Vizeacoumar and
Jack F. Greenblatt and
Andrew Emili and
Walid A. Houry Hsp110 is required for spindle length
control . . . . . . . . . . . . . . . . 623
Juan Carlos G. Cortés and
Mamiko Sato and
Javier Muñoz and
M. Belén Moreno and
Jose Angel Clemente-Ramos and
Mariona Ramos and
Hitoshi Okada and
Masako Osumi and
Angel Durán and
Juan Carlos Ribas Fission yeast Ags1 confers the essential
septum strength needed for safe gradual
cell abscission . . . . . . . . . . . . 637
Stephanie L. Gupton and
Daisy Riquelme and
Shannon K. Hughes-Alford and
Jenny Tadros and
Shireen S. Rudina and
Richard O. Hynes and
Douglas Lauffenburger and
Frank B. Gertler Mena binds $ \alpha $5 integrin directly
and modulates $ \alpha $5$ \beta $1
function . . . . . . . . . . . . . . . . 657
Ahmed Elbediwy and
Ceniz Zihni and
Stephen J. Terry and
Peter Clark and
Karl Matter and
Maria S. Balda Epithelial junction formation requires
confinement of Cdc42 activity by a novel
SH3BP1 complex . . . . . . . . . . . . . 677
Bianca Kraft and
Corinna D. Berger and
Veronika Wallkamm and
Herbert Steinbeisser and
Doris Wedlich Wnt-11 and Fz7 reduce cell adhesion in
convergent extension by sequestration of
PAPC and C-cadherin . . . . . . . . . . 695
Aurélia Vernay and
Sébastien Schaub and
Isabelle Guillas and
Martine Bassilana and
Robert A. Arkowitz A steep phosphoinositide bis-phosphate
gradient forms during fungal filamentous
growth . . . . . . . . . . . . . . . . . 711
Sara K. Olson and
Garrett Greenan and
Arshad Desai and
Thomas Müller-Reichert and
Karen Oegema Hierarchical assembly of the eggshell
and permeability barrier in \bionameC.
elegans . . . . . . . . . . . . . . . . 731
Brian Jenkins and
Helena Decker and
Marvin Bentley and
Julie Luisi and
Gary Banker A novel split kinesin assay identifies
motor proteins that interact with
distinct vesicle populations . . . . . . 749
Ben Short $ \gamma $-Tubulin flips the G1/S switch ??
Ben Short Rad53 keeps watch over mitochondrial DNA ??
Ben Short An enzyme complex helps fatten up lipid
droplets . . . . . . . . . . . . . . . . ??
Ben Short Putting SUMO and SoxE into context . . . 765
Caitlin Sedwick Tannishtha Reya: Classic pathways, new
views on cancer . . . . . . . . . . . . 766
Tim Davies and
Julie C. Canman Stuck in the middle: Rac, adhesion, and
cytokinesis . . . . . . . . . . . . . . 769
Volker Brinkmann and
Arturo Zychlinsky Neutrophil extracellular traps: Is
immunity the second function of
chromatin? . . . . . . . . . . . . . . . 773
Heather Edgerton-Morgan and
Berl R. Oakley $ \gamma $-Tubulin plays a key role in
inactivating APC/C$^{\rm Cdh1}$ at the
G$_1$--S boundary . . . . . . . . . . . 785
David G. Crider and
Luis J. García-Rodríguez and
Pallavi Srivastava and
Leonardo Peraza-Reyes and
Krishna Upadhyaya and
Istvan R. Boldogh and
Liza A. Pon Rad53 is essential for a mitochondrial
DNA inheritance checkpoint regulating G1
to S progression . . . . . . . . . . . . 793
Pei-Chih Lee and
Kimberly M. Taylor-Jaffe and
Kara M. Nordin and
Maneeshi S. Prasad and
Rachel M. Lander and
Carole LaBonne SUMOylated SoxE factors recruit Grg4 and
function as transcriptional repressors
in the neural crest . . . . . . . . . . 799
Fabien Le Grand and
Raphaëlle Grifone and
Philippos Mourikis and
Christophe Houbron and
Carine Gigaud and
Julien Pujol and
Marjorie Maillet and
Gilles Pag\`es and
Michael Rudnicki and
Shahragim Tajbakhsh and
Pascal Maire Six1 regulates stem cell repair
potential and self-renewal during
skeletal muscle regeneration . . . . . . 815
Hadas Elhanany-Tamir and
Yanxun V. Yu and
Miri Shnayder and
Ankit Jain and
Michael Welte and
Talila Volk Organelle positioning in muscles
requires cooperation between two KASH
proteins and microtubules . . . . . . . 833
Cornelia Wandke and
Marin Barisic and
Reinhard Sigl and
Veronika Rauch and
Frank Wolf and
Ana C. Amaro and
Chia H. Tan and
Antonio J. Pereira and
Ulrike Kutay and
Helder Maiato and
Patrick Meraldi and
Stephan Geley Human chromokinesins promote chromosome
congression and spindle microtubule
dynamics during mitosis . . . . . . . . 847
Ricardo Nunes Bastos and
Xenia Penate and
Michelle Bates and
Dean Hammond and
Francis A. Barr CYK4 inhibits Rac1-dependent PAK1 and
ARHGEF7 effector pathways during
cytokinesis . . . . . . . . . . . . . . 865
Eunyong Park and
Tom A. Rapoport Bacterial protein translocation requires
only one copy of the SecY complex in
vivo . . . . . . . . . . . . . . . . . . 881
Ningyi Xu and
Shaobing O. Zhang and
Ronald A. Cole and
Sean A. McKinney and
Fengli Guo and
Joel T. Haas and
Sudheer Bobba and
Robert V. Farese and
Ho Yi Mak The FATP1--DGAT2 complex facilitates
lipid droplet expansion at the ER--lipid
droplet interface . . . . . . . . . . . 895
Khanh Huy Bui and
Toshiki Yagi and
Ryosuke Yamamoto and
Ritsu Kamiya and
Takashi Ishikawa Polarity and asymmetry in the
arrangement of dynein and related
structures in the Chlamydomonas axoneme 913
Alexia Mahuzier and
Helori-Mael Gaudé and
Valentina Grampa and
Isabelle Anselme and
Flora Silbermann and
Margot Leroux-Berger and
Delphine Delacour and
Jerome Ezan and
Mireille Montcouquiol and
Sophie Saunier and
Sylvie Schneider-Maunoury and
Christine Vesque Dishevelled stabilization by the
ciliopathy protein Rpgrip1l is essential
for planar cell polarity . . . . . . . . 927
Stephanie Woo and
Michael P. Housley and
Orion D. Weiner and
Didier Y. R. Stainier Nodal signaling regulates endodermal
cell motility and actin dynamics via
Rac1 and Prex1 . . . . . . . . . . . . . 941
Mitch Leslie Lipins cause a lamina breakdown . . . . ??
Mitch Leslie Crumbs stands united against ROS . . . . ??
Mitch Leslie CaMKII points the way . . . . . . . . . ??
Mitch Leslie Unlocking the sperm's internal compass 955
Caitlin Sedwick Wendell Lim: Exploring the path not
chosen . . . . . . . . . . . . . . . . . 956
Alan F. Cowman and
Drew Berry and
Jake Baum The cellular and molecular basis for
malaria parasite invasion of the human
red blood cell . . . . . . . . . . . . . 961
Kai Yuan and
Jeffrey A. Farrell and
Patrick H. O'Farrell Different cyclin types collaborate to
reverse the S-phase checkpoint and
permit prompt mitosis . . . . . . . . . 973
Moritz Mall and
Thomas Walter and
Mátyás Gorjánácz and
Iain F. Davidson and
Thi Bach Nga Ly-Hartig and
Jan Ellenberg and
Iain W. Mattaj Mitotic lamin disassembly is triggered
by lipid-mediated signaling . . . . . . 981
François J.-M. Chartier and
Émilie J.-L. Hardy and
Patrick Laprise Crumbs limits oxidase-dependent
signaling to maintain epithelial
integrity and prevent photoreceptor cell
death . . . . . . . . . . . . . . . . . 991
Pablo H. Strobl-Mazzulla and
Marianne E. Bronner A PHD12--Snail2 repressive complex
epigenetically mediates neural crest
epithelial-to-mesenchymal transition . . 999
Alejo E. Rodríguez-Fraticelli and
Muriel Auzan and
Miguel A. Alonso and
Michel Bornens and
Fernando Martín-Belmonte Cell confinement controls centrosome
positioning and lumen initiation during
epithelial morphogenesis . . . . . . . . 1011
Laura Andrés-Delgado and
Olga M. Antón and
Francesca Bartolini and
Ana Ruiz-Sáenz and
Isabel Correas and
Gregg G. Gundersen and
Miguel A. Alonso INF2 promotes the formation of
detyrosinated microtubules necessary for
centrosome reorientation in T cells . . 1025
Anja K. Dunsch and
Dean Hammond and
Jennifer Lloyd and
Lothar Schermelleh and
Ulrike Gruneberg and
Francis A. Barr Dynein light chain 1 and a
spindle-associated adaptor promote
dynein asymmetry and spindle orientation 1039
Mado Lemieux and
Simon Labrecque and
Christian Tardif and
Étienne Labrie-Dion and
Éric LeBel and
Paul De Koninck Translocation of CaMKII to dendritic
microtubules supports the plasticity of
local synapses . . . . . . . . . . . . . 1055
Nachiket D. Kashikar and
Luis Alvarez and
Reinhard Seifert and
Ingo Gregor and
Oliver Jäckle and
Michael Beyermann and
Eberhard Krause and
U. Benjamin Kaupp Temporal sampling, resetting, and
adaptation orchestrate gradient sensing
in sperm . . . . . . . . . . . . . . . . 1075
Mitch Leslie B23 steals to stop cell-killing pair . . ??
Mitch Leslie microRNA's big role in preventing tumors ??
Mitch Leslie Dynein's helper not so helpful . . . . . ??
Mitch Leslie Cytoskeleton key . . . . . . . . . . . . 3
Caitlin Sedwick Cédric Blanpain: The stories stem cells
tell . . . . . . . . . . . . . . . . . . 4
Priya Prakash Budde and
Elizabeth H. Williams and
Tom Misteli Cell biology: At the center of modern
biomedicine . . . . . . . . . . . . . . 7
Leslie B. Gordon and
Kan Cao and
Francis S. Collins Progeria: Translational insights from
cell biology . . . . . . . . . . . . . . 9
Matthew J. Davis and
Joseph Schlessinger The genesis of Zelboraf: Targeting
mutant B--Raf in melanoma . . . . . . . 15
Frank Rigo and
Yimin Hua and
Adrian R. Krainer and
C. Frank Bennett Antisense-based therapy for the
treatment of spinal muscular atrophy . . 21
Daisuke Izawa and
Jonathon Pines Mad2 and the APC/C compete for the same
site on Cdc20 to ensure proper
chromosome segregation . . . . . . . . . 27
Alexandre R. Gingras and
Jian J. Liu and
Mark H. Ginsberg Structural basis of the junctional
anchorage of the cerebral cavernous
malformations complex . . . . . . . . . 39
Tobias Ulbricht and
Mohammad Alzrigat and
Almut Horch and
Nina Reuter and
Anna von Mikecz and
Viktor Steimle and
Eberhard Schmitt and
Oliver H. Krämer and
Thomas Stamminger and
Peter Hemmerich PML promotes MHC class II gene
expression by stabilizing the class II
transactivator . . . . . . . . . . . . . 49
Sang Bae Lee and
Chung Kwon Kim and
Kyung-Hoon Lee and
Jee-Yin Ahn S-nitrosylation of B23/nucleophosmin by
GAPDH protects cells from the
SIAH1--GAPDH death cascade . . . . . . . 65
Matteo J. Marzi and
Eleonora M. R. Puggioni and
Valentina Dall'Olio and
Gabriele Bucci and
Loris Bernard and
Fabrizio Bianchi and
Marco Crescenzi and
Pier Paolo Di Fiore and
Francesco Nicassio Differentiation-associated microRNAs
antagonize the Rb--E2F pathway to
restrict proliferation . . . . . . . . . 77
Sachin Kotak and
Coralie Busso and
Pierre Gönczy Cortical dynein is critical for proper
spindle positioning in human cells . . . 97
Qing-Tao Shen and
Peter P. Hsiue and
Charles V. Sindelar and
Matthew D. Welch and
Kenneth G. Campellone and
Hong-Wei Wang Structural insights into WHAMM-mediated
cytoskeletal coordination during
membrane remodeling . . . . . . . . . . 111
Marta Blamowska and
Walter Neupert and
Kai Hell Biogenesis of the mitochondrial Hsp70
chaperone . . . . . . . . . . . . . . . 125
Steffi Gruschke and
Katharina Römpler and
Markus Hildenbeutel and
Kirsten Kehrein and
Inge Kühl and
Nathalie Bonnefoy and
Martin Ott The Cbp3--Cbp6 complex coordinates
cytochrome b synthesis with bc$_1$
complex assembly in yeast mitochondria 137
Benjamin D. Engel and
Hiroaki Ishikawa and
Kimberly A. Wemmer and
Stefan Geimer and
Ken-ichi Wakabayashi and
Masafumi Hirono and
Branch Craige and
Gregory J. Pazour and
George B. Witman and
Ritsu Kamiya and
Wallace F. Marshall The role of retrograde intraflagellar
transport in flagellar assembly,
maintenance, and function . . . . . . . 151
Rui Duan and
Peng Jin and
Fengbao Luo and
Guofeng Zhang and
Nathan Anderson and
Elizabeth H. Chen Group I PAKs function downstream of Rac
to promote podosome invasion during
myoblast fusion in vivo . . . . . . . . 169
Ben Short The mystery of the (not) missing
coenzyme . . . . . . . . . . . . . . . . ??
Ben Short Sec and Tat share the workload . . . . . ??
Ben Short Tiam1 increases turnover . . . . . . . . ??
Ben Short Fyn regeneration . . . . . . . . . . . . 189
Caitlin Sedwick Laurie Boyer: Stem cell circuitry for
commitment . . . . . . . . . . . . . . . 190
Scott X. Atwood and
Anne Lynn S. Chang and
Anthony E. Oro Hedgehog pathway inhibition and the race
against tumor evolution . . . . . . . . 193
Tsukasa Okiyoneda and
Gergely L. Lukacs Fixing cystic fibrosis by correcting
CFTR domain assembly . . . . . . . . . . 199
Riekelt H. Houtkooper and
Johan Auwerx Exploring the therapeutic space around
NAD$^+$ . . . . . . . . . . . . . . . . 205
Mirna Perez-Moreno and
Elaine Fuchs Guilt by association: What p120-catenin
has to hide . . . . . . . . . . . . . . 211
Jérôme Lapointe and
Ying Wang and
Eve Bigras and
Siegfried Hekimi The submitochondrial distribution of
ubiquinone affects respiration in
long-lived Mclk1$^{+/} - $ mice . . . . 215
Sa Kan Yoo and
Christina M. Freisinger and
Danny C. LeBert and
Anna Huttenlocher Early redox, Src family kinase, and
calcium signaling integrate wound
responses and tissue regeneration in
zebrafish . . . . . . . . . . . . . . . 225
Alex Pines and
Mischa G. Vrouwe and
Jurgen A. Marteijn and
Dimitris Typas and
Martijn S. Luijsterburg and
Medine Cansoy and
Paul Hensbergen and
André Deelder and
Anton de Groot and
Syota Matsumoto and
Kaoru Sugasawa and
Nicolas Thoma and
Wim Vermeulen and
Harry Vrieling and
Leon Mullenders PARP1 promotes nucleotide excision
repair through DDB2 stabilization and
recruitment of ALC1 . . . . . . . . . . 235
Fangwei Wang and
Natalia P. Ulyanova and
John R. Daum and
Debasis Patnaik and
Anna V. Kateneva and
Gary J. Gorbsky and
Jonathan M. G. Higgins Haspin inhibitors reveal centromeric
functions of Aurora B in chromosome
segregation . . . . . . . . . . . . . . 251
Anna De Antoni and
Stefano Maffini and
Stefan Knapp and
Andrea Musacchio and
Stefano Santaguida A small-molecule inhibitor of Haspin
alters the kinetochore functions of
Aurora B . . . . . . . . . . . . . . . . 269
Ana R. R. Maia and
Zaira Garcia and
Lilian Kabeche and
Marin Barisic and
Stefano Maffini and
Sandra Macedo-Ribeiro and
Iain M. Cheeseman and
Duane A. Compton and
Irina Kaverina and
Helder Maiato Cdk1 and Plk1 mediate a CLASP2
phospho-switch that stabilizes
kinetochore--microtubule attachments . . 285
Rebecca Keller and
Jeanine de Keyzer and
Arnold J. M. Driessen and
Tracy Palmer Co-operation between different targeting
pathways during integration of a
membrane protein . . . . . . . . . . . . 303
Joseph P. Wynne and
Jinhua Wu and
Wenjuan Su and
Adam Mor and
Nikolaos Patsoukis and
Vassiliki A. Boussiotis and
Stevan R. Hubbard and
Mark R. Philips Rap1-interacting adapter molecule (RIAM)
associates with the plasma membrane via
a proximity detector . . . . . . . . . . 317
Shujie Wang and
Takashi Watanabe and
Kenji Matsuzawa and
Akira Katsumi and
Mai Kakeno and
Toshinori Matsui and
Feng Ye and
Kazuhide Sato and
Kiyoko Murase and
Ikuko Sugiyama and
Kazushi Kimura and
Akira Mizoguchi and
Mark H. Ginsberg and
John G. Collard and
Kozo Kaibuchi Tiam1 interaction with the PAR complex
promotes talin-mediated Rac1 activation
during polarized cell migration . . . . 331
Ivano Amelio and
Anna Maria Lena and
Giuditta Viticchi\`e and
Ruby Shalom-Feuerstein and
Alessandro Terrinoni and
David Dinsdale and
Giandomenico Russo and
Claudia Fortunato and
Elena Bonanno and
Luigi Giusto Spagnoli and
Daniel Aberdam and
Richard Austen Knight and
Eleonora Candi and
Gerry Melino miR-24 triggers epidermal
differentiation by controlling actin
adhesion and cell migration . . . . . . 347
Benjamin A. Nanes and
Christine Chiasson-MacKenzie and
Anthony M. Lowery and
Noboru Ishiyama and
Victor Faundez and
Mitsuhiko Ikura and
Peter A. Vincent and
Andrew P. Kowalczyk p120-catenin binding masks an endocytic
signal conserved in classical cadherins 365
Iman Sahly and
Eric Dufour and
Cataldo Schietroma and
Vincent Michel and
Amel Bahloul and
Isabelle Perfettini and
Elise Pepermans and
Amrit Estivalet and
Diane Carette and
Asadollah Aghaie and
Inga Ebermann and
Andrea Lelli and
Maria Iribarne and
Jean-Pierre Hardelin and
Dominique Weil and
José-Alain Sahel and
Aziz El-Amraoui and
Christine Petit Localization of Usher 1 proteins to the
photoreceptor calyceal processes, which
are absent from mice . . . . . . . . . . 381
Mitch Leslie HIV's kinesin chauffeur . . . . . . . . ??
Mitch Leslie Only skin deep, thanks to microtubules ??
Mitch Leslie N-WASP helps cancer cells open up . . . ??
Mitch Leslie Stay-at-home transcription factor saves
axons . . . . . . . . . . . . . . . . . 403
Caitlin Sedwick Fumiyo Ikeda: Ubiquitin lines up for
action . . . . . . . . . . . . . . . . . 405
Morten Lindow and
Sakari Kauppinen Discovering the first microRNA-targeted
drug . . . . . . . . . . . . . . . . . . 407
Lawrence Steinman The discovery of natalizumab, a potent
therapeutic for multiple sclerosis . . . 413
Polakit Teekakirikul and
Robert F. Padera and
J. G. Seidman and
Christine E. Seidman Hypertrophic cardiomyopathy: Translating
cellular cross talk into therapeutics 417
David Boettiger Using force to visualize conformational
activation of integrins . . . . . . . . 423
Bharat Joshi and
Michele Bastiani and
Scott S. Strugnell and
Cecile Boscher and
Robert G. Parton and
Ivan R. Nabi Phosphocaveolin-1 is a mechanotransducer
that induces caveola biogenesis via Egr1
transcriptional regulation . . . . . . . 425
Bhuvaneish Thangaraj Selvaraj and
Nicolas Frank and
Florian L. P. Bender and
Esther Asan and
Michael Sendtner Local axonal function of STAT3 rescues
axon degeneration in the pmn model of
motoneuron disease . . . . . . . . . . . 437
Chathurani S. Jayasena and
Marianne E. Bronner Rbms3 functions in craniofacial
development by posttranscriptionally
modulating TGF-$ \beta $ signaling . . . 453
Raphaël Gaudin and
Bruna Cunha de Alencar and
Mabel Jouve and
Stefano B\`erre and
Emmanuel Le Bouder and
Michael Schindler and
Aditi Varthaman and
François-Xavier Gobert and
Philippe Benaroch Critical role for the kinesin KIF3A in
the HIV life cycle in primary human
macrophages . . . . . . . . . . . . . . 467
Emmanuel Dornier and
Franck Coumailleau and
Jean-François Ottavi and
Julien Moretti and
Claude Boucheix and
Philippe Mauduit and
François Schweisguth and
Eric Rubinstein TspanC8 tetraspanins regulate
ADAM10/Kuzbanian trafficking and promote
Notch activation in flies and mammals 481
Wei Chen and
Jizhong Lou and
Evan A. Evans and
Cheng Zhu Observing force-regulated conformational
changes and ligand dissociation from a
single integrin on cells . . . . . . . . 497
Kaelyn D. Sumigray and
Henry P. Foote and
Terry Lechler Noncentrosomal microtubules and type II
myosins potentiate epidermal cell
adhesion and barrier formation . . . . . 513
Xinzi Yu and
Tobias Zech and
Laura McDonald and
Esther Garcia Gonzalez and
Ang Li and
Iain Macpherson and
Juliane P. Schwarz and
Heather Spence and
Kinga Futó and
Paul Timpson and
Colin Nixon and
Yafeng Ma and
Ines M. Anton and
Balázs Visegrády and
Robert H. Insall and
Karin Oien and
Karen Blyth and
Jim C. Norman and
Laura M. Machesky N-WASP coordinates the delivery and
F-actin-mediated capture of MT1-MMP at
invasive pseudopods . . . . . . . . . . 527
Mei Rosa Ng and
Achim Besser and
Gaudenz Danuser and
Joan S. Brugge Substrate stiffness regulates
cadherin-dependent collective migration
through myosin--II contractility . . . . 545
Ben Short ARL-13 SUMO wrestles receptors into
cilia . . . . . . . . . . . . . . . . . ??
Ben Short Dnm1's recruitment strategy . . . . . . ??
Ben Short The fellowship of the Z ring . . . . . . ??
Ben Short Cdc42 helps cancer cells make their exit 567
Caitlin Sedwick Gaudenz Danuser: The symphony of the
cell . . . . . . . . . . . . . . . . . . 568
Oliver Hantschel and
Giulio Superti-Furga Cell biology: a key driver of
therapeutic innovation . . . . . . . . . 571
Lawrence S. B. Goldstein New frontiers in human cell biology and
medicine: Can pluripotent stem cells
deliver? . . . . . . . . . . . . . . . . 577
Alfred L. Goldberg Development of proteasome inhibitors as
research tools and cancer drugs . . . . 583
Yujie Li and
Qing Zhang and
Qing Wei and
Yuxia Zhang and
Kun Ling and
Jinghua Hu SUMOylation of the small GTPase ARL-13
promotes ciliary targeting of sensory
receptors . . . . . . . . . . . . . . . 589
Astrid Klein and
Lars Israel and
Sebastian W. K. Lackey and
Frank E. Nargang and
Axel Imhof and
Wolfgang Baumeister and
Walter Neupert and
Dennis R. Thomas Characterization of the insertase for $
\beta $-barrel proteins of the outer
mitochondrial membrane . . . . . . . . . 599
Huyen T. Bui and
Mary A. Karren and
Debjani Bhar and
Janet M. Shaw A novel motif in the yeast mitochondrial
dynamin Dnm1 is essential for adaptor
binding and membrane recruitment . . . . 613
Allan D. TerBush and
Katherine W. Osteryoung Distinct functions of chloroplast FtsZ1
and FtsZ2 in Z-ring structure and
remodeling . . . . . . . . . . . . . . . 623
Priyanka Sivadas and
Jennifer M. Dienes and
Martin St. Maurice and
William D. Meek and
Pinfen Yang A flagellar A-kinase anchoring protein
with two amphipathic helices forms a
structural scaffold in the radial spoke
complex . . . . . . . . . . . . . . . . 639
Nicolas Reymond and
Jae Hong Im and
Ritu Garg and
Francisco M. Vega and
Barbara Borda d'Agua and
Philippe Riou and
Susan Cox and
Ferran Valderrama and
Ruth J. Muschel and
Anne J. Ridley Cdc42 promotes transendothelial
migration of cancer cells through $
\beta $1 integrin . . . . . . . . . . . 653
Matthew Raab and
Joe Swift and
P. C. Dave P. Dingal and
Palak Shah and
Jae-Won Shin and
Dennis E. Discher Crawling from soft to stiff matrix
polarizes the cytoskeleton and
phosphoregulates myosin--II heavy chain 669
Arnab Sen and
Zsanett Nagy-Zsvér-Vadas and
Michael P. Krahn Drosophila PATJ supports adherens
junction stability by modulating Myosin
light chain activity . . . . . . . . . . 685
Jing Chen and
Oxana E. Nekrasova and
Dipal M. Patel and
Jodi L. Klessner and
Lisa M. Godsel and
Jennifer L. Koetsier and
Evangeline V. Amargo and
Bhushan V. Desai and
Kathleen J. Green The C-terminal unique region of
desmoglein 2 inhibits its
internalization via tail--tail
interactions . . . . . . . . . . . . . . 699
Ben Short Why a microRNA's absence makes the heart
grow larger . . . . . . . . . . . . . . ??
Ben Short A SIMPLE explanation for
Charcot--Marie--Tooth disease . . . . . ??
Ben Short Global sourcing for ring construction ??
Ben Short KIF4 helps mitotic chromosomes get in
shape . . . . . . . . . . . . . . . . . 715
Caitlin Sedwick Stefano Bertuzzi: Science first . . . . 716
Mar Carmena Flies stretch their cells to avoid a
chromatin trap . . . . . . . . . . . . . 719
Frances M. Platt and
Barry Boland and
Aarnoud C. van der Spoel Lysosomal storage disorders: The
cellular impact of lysosomal dysfunction 723
Haitong Hou and
Zhou Zhou and
Yu Wang and
Jiyong Wang and
Scott P. Kallgren and
Tatiana Kurchuk and
Elizabeth A. Miller and
Fred Chang and
Songtao Jia Csi1 links centromeres to the nuclear
envelope for centromere clustering . . . 735
Shaila Kotadia and
Emilie Montembault and
William Sullivan and
Anne Royou Cell elongation is an adaptive response
for clearing long chromatid arms from
the cleavage plane . . . . . . . . . . . 745
Kumiko Samejima and
Itaru Samejima and
Paola Vagnarelli and
Hiromi Ogawa and
Giulia Vargiu and
David A. Kelly and
Flavia de Lima Alves and
Alastair Kerr and
Lydia C. Green and
Damien F. Hudson and
Shinya Ohta and
Carol A. Cooke and
Christine J. Farr and
Juri Rappsilber and
William C. Earnshaw Mitotic chromosomes are compacted
laterally by KIF4 and condensin and
axially by topoisomerase II$ \alpha $ 755
Lisa Kappel and
Mathias Loibl and
Gertrude Zisser and
Isabella Klein and
Gernot Fruhmann and
Christof Gruber and
Stefan Unterweger and
Gerald Rechberger and
Brigitte Pertschy and
Helmut Bergler Rlp24 activates the AAA--ATPase Drg1 to
initiate cytoplasmic pre-60S maturation 771
Faye M. Drawnel and
Dagmar Wachten and
Jeffery D. Molkentin and
Marjorie Maillet and
Jan Magnus Aronsen and
Fredrik Swift and
Ivar Sjaastad and
Ning Liu and
Daniele Catalucci and
Katsuhiko Mikoshiba and
Chihiro Hisatsune and
Hanneke Okkenhaug and
Simon R. Andrews and
Martin D. Bootman and
H. Llewelyn Roderick Mutual antagonism between IP$_3$ RII and
miRNA-133a regulates calcium signals and
cardiac hypertrophy . . . . . . . . . . 783
Samuel M. Lee and
Lih-Shen Chin and
Lian Li Charcot-Marie-Tooth disease-linked
protein SIMPLE functions with the ESCRT
machinery in endosomal trafficking . . . 799
Sang-oh Han and
Kunhong Xiao and
Jihee Kim and
Jiao-Hui Wu and
James W. Wisler and
Nobuhiro Nakamura and
Neil J. Freedman and
Sudha K. Shenoy MARCH2 promotes endocytosis and
lysosomal sorting of carvedilol-bound $
\beta_2 $-adrenergic receptors . . . . . 817
Junqi Huang and
Yinyi Huang and
Haochen Yu and
Dhivya Subramanian and
Anup Padmanabhan and
Rahul Thadani and
Yaqiong Tao and
Xie Tang and
Roland Wedlich-Soldner and
Mohan K. Balasubramanian Nonmedially assembled F-actin cables
incorporate into the actomyosin ring in
fission yeast . . . . . . . . . . . . . 831
Wenjing Li and
Takashi Moriwaki and
Tomomi Tani and
Takashi Watanabe and
Kozo Kaibuchi and
Gohta Goshima Reconstitution of dynamic microtubules
with \bionameDrosophila XMAP215, EB1,
and Sentin . . . . . . . . . . . . . . . 849
Nia J. Bryant and
David E. James The Sec1p/Munc18 (SM) protein, Vps45p,
cycles on and off membranes during
vesicle transport . . . . . . . . . . . 863
Ben Short Release notes for dense-core vesicles ??
Ben Short Opening up the ER's gatekeeper . . . . . ??
Ben Short Segregating Bub1's mitotic functions . . ??
Ben Short Farp1 gives both sides of the story . . 867
Caitlin Sedwick John Heuser: Capture the moment . . . . 868
Neil J. Ganem and
David Pellman Linking abnormal mitosis to the
acquisition of DNA damage . . . . . . . 871
Rhea van de Bospoort and
Margherita Farina and
Sabine K. Schmitz and
Arthur de Jong and
Heidi de Wit and
Matthijs Verhage and
Ruud F. Toonen Munc13 controls the location and
efficiency of dense-core vesicle release
in neurons . . . . . . . . . . . . . . . 883
Dimitri Conomos and
Michael D. Stutz and
Mark Hills and
Axel A. Neumann and
Tracy M. Bryan and
Roger R. Reddel and
Hilda A. Pickett Variant repeats are interspersed
throughout the telomeres and recruit
nuclear receptors in ALT cells . . . . . 893
Steven F. Trueman and
Elisabet C. Mandon and
Reid Gilmore A gating motif in the translocation
channel sets the hydrophobicity
threshold for signal sequence function 907
Sarah Whitehouse and
Vicki A. M. Gold and
Alice Robson and
William J. Allen and
Richard B. Sessions and
Ian Collinson Mobility of the SecA $2$-helix-finger is
not essential for polypeptide
translocation via the SecYEG complex . . 919
Robin M. Ricke and
Karthik B. Jeganathan and
Liviu Malureanu and
Andrew M. Harrison and
Jan M. van Deursen Bub1 kinase activity drives error
correction and mitotic checkpoint
control but not tumor suppression . . . 931
Syed M. Ahmed and
Brigitte L. Thériault and
Maruti Uppalapati and
Catherine W. N. Chiu and
Brenda L. Gallie and
Sachdev S. Sidhu and
Stéphane Angers KIF14 negatively regulates Rap1a--Radil
signaling during breast cancer
progression . . . . . . . . . . . . . . 951
Raghuvir Viswanatha and
Patrice Y. Ohouo and
Marcus B. Smolka and
Anthony Bretscher Local phosphocycling mediated by LOK/SLK
restricts ezrin function to the apical
aspect of epithelial cells . . . . . . . 969
Lucas Cheadle and
Thomas Biederer The novel synaptogenic protein Farp1
links postsynaptic cytoskeletal dynamics
and transsynaptic organization . . . . . 985
Fubito Nakatsu and
Jeremy M. Baskin and
Jeeyun Chung and
Lukas B. Tanner and
Guanghou Shui and
Sang Yoon Lee and
Michelle Pirruccello and
Mingming Hao and
Nicholas T. Ingolia and
Markus R. Wenk and
Pietro De Camilli PtdIns4P synthesis by PI4KIII$ \alpha $
at the plasma membrane and its impact on
plasma membrane identity . . . . . . . . 1003
Ben Short Apoptotic regulators dispose of the
midbody . . . . . . . . . . . . . . . . ??
Ben Short Secretory proteins hail a cab at the TGN ??
Ben Short How endothelial junctions get
deep--Syx'd . . . . . . . . . . . . . . ??
Ben Short Lkb1 takes different paths to
morphogenesis . . . . . . . . . . . . . 1019
Caitlin Sedwick Li-Huei Tsai: I well remember . . . . . 1020
Liang Cai and
Keith E. Mostov Cell height: Tao rising . . . . . . . . 1023
Anna Noatynska and
Monica Gotta and
Patrick Meraldi Mitotic spindle (DIS)orientation and
DISease: Cause or consequence? . . . . . 1025
Hervé Menoni and
Jan H. J. Hoeijmakers and
Wim Vermeulen Nucleotide excision repair--initiating
proteins bind to oxidative DNA lesions
in vivo . . . . . . . . . . . . . . . . 1037
Yongping Chai and
Dong Tian and
Yihong Yang and
Guoxin Feng and
Ze Cheng and
Wei Li and
Guangshuo Ou Apoptotic regulators promote cytokinetic
midbody degradation in \bionameC.
elegans . . . . . . . . . . . . . . . . 1047
Julia von Blume and
Anne-Marie Alleaume and
Christine Kienzle and
Amado Carreras-Sureda and
Miguel Valverde and
Vivek Malhotra Cab45 is required for
Ca$^{2+}$-dependent secretory cargo
sorting at the trans-Golgi network . . . 1057
Céline Courilleau and
Catherine Chailleux and
Alain Jauneau and
Fanny Grimal and
Sébastien Briois and
Elisa Boutet-Robinet and
François Boudsocq and
Didier Trouche and
Yvan Canitrot The chromatin remodeler p400 ATPase
facilitates Rad51-mediated repair of DNA
double-strand breaks . . . . . . . . . . 1067
Kerstin N. Schmidt and
Stefanie Kuhns and
Annett Neuner and
Birgit Hub and
Hanswalter Zentgraf and
Gislene Pereira Cep164 mediates vesicular docking to the
mother centriole during early steps of
ciliogenesis . . . . . . . . . . . . . . 1083
Siu P. Ngok and
Rory Geyer and
Miaoliang Liu and
Antonis Kourtidis and
Sudesh Agrawal and
Chuanshen Wu and
Himabindu Reddy Seerapu and
Laura J. Lewis-Tuffin and
Karen L. Moodie and
Deborah Huveldt and
Ruth Marx and
Jay M. Baraban and
Peter Storz and
Arie Horowitz and
Panos Z. Anastasiadis VEGF and Angiopoietin-1 exert opposing
effects on cell junctions by regulating
the Rho GEF Syx . . . . . . . . . . . . 1103
Bryan Lo and
Geraldine Strasser and
Meredith Sagolla and
Cary D. Austin and
Melissa Junttila and
Ira Mellman Lkb1 regulates organogenesis and early
oncogenesis along AMPK-dependent and
-independent pathways . . . . . . . . . 1117
Juan Manuel Gomez and
Ying Wang and
Veit Riechmann Tao controls epithelial morphogenesis by
promoting Fasciclin 2 endocytosis . . . 1131
Hyung Joon Kim and
Vikram Prasad and
Seok-Won Hyung and
Zang Hee Lee and
Sang-Won Lee and
Aditi Bhargava and
David Pearce and
Youngkyun Lee and
Hong-Hee Kim Plasma membrane calcium ATPase regulates
bone mass by fine-tuning osteoclast
differentiation and survival . . . . . . 1145
Mitch Leslie Kinetochore complexes need teamwork . . ??
Mitch Leslie Blame ATAD5 for factory closures . . . . ??
Mitch Leslie Cdc42 helps cells take bigger bites . . ??
Mitch Leslie The two stages of cell fusion . . . . . 3
Caitlin Sedwick Gillian Griffiths: How T cells get on
target . . . . . . . . . . . . . . . . . 4
Ana Stankovic and
Lars E. T. Jansen Reductionism at the vertebrate
kinetochore . . . . . . . . . . . . . . 7
Keith Burridge and
Erika S. Wittchen The tension mounts: Stress fibers as
force-generating mechanotransducers . . 9
Fabienne Lampert and
Christine Mieck and
Gregory M. Alushin and
Eva Nogales and
Stefan Westermann Molecular requirements for the formation
of a kinetochore--microtubule interface
by Dam1 and Ndc80 complexes . . . . . . 21
Kyoo-young Lee and
Haiqing Fu and
Mirit I. Aladjem and
Kyungjae Myung ATAD5 regulates the lifespan of DNA
replication factories by modulating PCNA
level on the chromatin . . . . . . . . . 31
Tetsuya Hori and
Wei-Hao Shang and
Kozo Takeuchi and
Tatsuo Fukagawa The CCAN recruits CENP--A to the
centromere and forms the structural core
for kinetochore assembly . . . . . . . . 45
Ramya Nair and
Juliane Lauks and
SangYong Jung and
Nancy E. Cooke and
Heidi de Wit and
Nils Brose and
Manfred W. Kilimann and
Matthijs Verhage and
JeongSeop Rhee Neurobeachin regulates neurotransmitter
receptor trafficking to synapses . . . . 61
Sina Mohammadi and
Ralph R. Isberg Cdc42 interacts with the exocyst complex
to promote phagocytosis . . . . . . . . 81
Maryna Kapustina and
Timothy C. Elston and
Ken Jacobson Compression and dilation of the
membrane-cortex layer generates rapid
changes in cell shape . . . . . . . . . 95
Evgenia Leikina and
Kamran Melikov and
Sarmistha Sanyal and
Santosh K. Verma and
Bokkee Eun and
Claudia Gebert and
Karl Pfeifer and
Vladimir A. Lizunov and
Michael M. Kozlov and
Leonid V. Chernomordik Extracellular annexins and dynamin are
important for sequential steps in
myoblast fusion . . . . . . . . . . . . 109
Mitch Leslie Ran's downhill slide during mitosis . . ??
Mitch Leslie Fly chromosomes don't just ride the tips ??
Mitch Leslie Spreading around a Wnt protein . . . . . ??
Mitch Leslie How to live without BRCA1 . . . . . . . 127
Caitlin Sedwick Samara Reck--Peterson: Dynein defies
expectations . . . . . . . . . . . . . . 128
Francis J. McNally Mechanisms of spindle positioning . . . 131
Yeon-Tae Jeong and
Mario Rossi and
Lukas Cermak and
Anita Saraf and
Laurence Florens and
Michael P. Washburn and
Patrick Sung and
Carl L. Schildkraut and
Michele Pagano FBH1 promotes DNA double-strand breakage
and apoptosis in response to DNA
replication stress . . . . . . . . . . . 141
Keisuke Hasegawa and
Sung Jin Ryu and
Petr Kaláb Chromosomal gain promotes formation of a
steep RanGTP gradient that drives
mitosis in aneuploid cells . . . . . . . 151
Michael Lazarou and
Derek P. Narendra and
Seok Min Jin and
Ephrem Tekle and
Soojay Banerjee and
Richard J. Youle PINK1 drives Parkin self-association and
HECT-like E3 activity upstream of
mitochondrial binding . . . . . . . . . 163
Jessica Cottarel and
Philippe Frit and
Oriane Bombarde and
Bernard Salles and
Aurélie Négrel and
Stéphanie Bernard and
Penny A. Jeggo and
Michael R. Lieber and
Mauro Modesti and
Patrick Calsou A noncatalytic function of the ligation
complex during nonhomologous end joining 173
David A. Grotsky and
Ignacio Gonzalez-Suarez and
Anna Novell and
Martin A. Neumann and
Sree C. Yaddanapudi and
Monica Croke and
Montserrat Martinez-Alonso and
Abena B. Redwood and
Sylvia Ortega-Martinez and
Zhihui Feng and
Enrique Lerma and
Teresa Ramon y Cajal and
Junran Zhang and
Xavier Matias-Guiu and
Adriana Dusso and
Susana Gonzalo BRCA1 loss activates cathepsin
L-mediated degradation of 53BP1 in
breast cancer cells . . . . . . . . . . 187
Stuart Cane and
Anna A. Ye and
Sasha J. Luks-Morgan and
Thomas J. Maresca Elevated polar ejection forces stabilize
kinetochore--microtubule attachments . . 203
Keisuke Kamimura and
Kohei Ueno and
Jun Nakagawa and
Rie Hamada and
Minoru Saitoe and
Nobuaki Maeda Perlecan regulates bidirectional Wnt
signaling at the \bionameDrosophila
neuromuscular junction . . . . . . . . . 219
Ben Short Working at the tail end of tubulin . . . ??
Ben Short GEFs help Rabs find their target . . . . ??
Ben Short Chemokine turnover keeps neurons on
track . . . . . . . . . . . . . . . . . ??
Ben Short MDGAs help the brain lose its
inhibitions . . . . . . . . . . . . . . 237
Caitlin Sedwick Carl-Philipp Heisenberg: Early embryos
make a big move . . . . . . . . . . . . 238
Natasha T. Snider and
Jessica M. Leonard and
Raymond Kwan and
Nicholas W. Griggs and
Liangyou Rui and
M. Bishr Omary Glucose and SIRT2 reciprocally mediate
the regulation of keratin 8 by lysine
acetylation . . . . . . . . . . . . . . 241
Yasuhisa Sakamoto and
Batiste Boëda and
Sandrine Etienne-Manneville APC binds intermediate filaments and is
required for their reorganization during
cell migration . . . . . . . . . . . . . 249
Andrea E. Prota and
Maria M. Magiera and
Marijn Kuijpers and
Katja Bargsten and
Daniel Frey and
Mara Wieser and
Rolf Jaussi and
Casper C. Hoogenraad and
Richard A. Kammerer and
Carsten Janke and
Michel O. Steinmetz Structural basis of tubulin tyrosination
by tubulin tyrosine ligase . . . . . . . 259
Carsten Wloka and
Elizabeth A. Vallen and
Lydia Thé and
Xiaodong Fang and
Younghoon Oh and
Erfei Bi Immobile myosin--II plays a scaffolding
role during cytokinesis in budding yeast 271
Julia Blümer and
Juliana Rey and
Leif Dehmelt and
Tomá\vs Mazel and
Yao-Wen Wu and
Philippe Bastiaens and
Roger S. Goody and
Aymelt Itzen RabGEFs are a major determinant for
specific Rab membrane targeting . . . . 287
Vanesa M. Tomatis and
Andreas Papadopulos and
Nancy T. Malintan and
Sally Martin and
Tristan Wallis and
Rachel S. Gormal and
John Kendrick-Jones and
Folma Buss and
Frédéric A. Meunier Myosin VI small insert isoform maintains
exocytosis by tethering secretory
granules to the cortical actin . . . . . 301
Katherine L. Pettem and
Daisaku Yokomaku and
Hideto Takahashi and
Yuan Ge and
Ann Marie Craig Interaction between autism-linked MDGAs
and neuroligins suppresses inhibitory
synapse development . . . . . . . . . . 321
Stephen W. Lewellis and
Danielle Nagelberg and
Abhi Subedi and
Alison Staton and
Michelle LeBlanc and
Antonio Giraldez and
Holger Knaut Precise SDF1-mediated cell guidance is
achieved through ligand clearance and
microRNA-mediated decay . . . . . . . . 337
Yujie Li and
Qing Zhang and
Qing Wei and
Yuxia Zhang and
Kun Ling and
Jinghua Hu SUMOylation of the small GTPase ARL-13
promotes ciliary targeting of sensory
receptors . . . . . . . . . . . . . . . 357
Addolarata Pisconti and
Silvia Brunelli and
Monica Di Padova and
Clara De Palma and
Daniela Deponti and
Silvia Baesso and
Vittorio Sartorelli and
Giulio Cossu and
Emilio Clementi Follistatin induction by nitric oxide
through cyclic GMP: a tightly regulated
signaling pathway that controls myoblast
fusion . . . . . . . . . . . . . . . . . 359
Mitch Leslie Telocentrosomes organize telomere
gathering . . . . . . . . . . . . . . . ??
Mitch Leslie SecYEG gets grabby with new proteins . . ??
Mitch Leslie Condensin II helps sisters find their
identity . . . . . . . . . . . . . . . . ??
Mitch Leslie Endocytosis puts exocytosis in pole
position . . . . . . . . . . . . . . . . 363
Caitlin Sedwick Stephen Doxsey: At the (peri)center of
things . . . . . . . . . . . . . . . . . 364
Clifford V. Harding and
John E. Heuser and
Philip D. Stahl Exosomes: Looking back three decades and
into the future . . . . . . . . . . . . 367
Graça Raposo and
Willem Stoorvogel Extracellular vesicles: Exosomes,
microvesicles, and friends . . . . . . . 373
Masashi Yoshida and
Satoshi Katsuyama and
Kazuki Tateho and
Hiroto Nakamura and
Junpei Miyoshi and
Tatsunori Ohba and
Hirotada Matsuhara and
Futaba Miki and
Koei Okazaki and
Tokuko Haraguchi and
Osami Niwa and
Yasushi Hiraoka and
Ayumu Yamamoto Microtubule-organizing center formation
at telomeres induces meiotic telomere
clustering . . . . . . . . . . . . . . . 385
David Akopian and
Kush Dalal and
Kuang Shen and
Franck Duong and
Shu-ou Shan SecYEG activates GTPases to drive the
completion of cotranslational protein
targeting . . . . . . . . . . . . . . . 397
Mini Jose and
Sylvain Tollis and
Deepak Nair and
Jean-Baptiste Sibarita and
Derek McCusker Robust polarity establishment occurs via
an endocytosis-based cortical corralling
mechanism . . . . . . . . . . . . . . . 407
Ingyu Kim and
Weijun Pan and
Sara A. Jones and
Youxin Zhang and
Xiaowei Zhuang and
Dianqing Wu Clathrin and AP2 are required for
PtdIns(4,5)P$_2$-mediated formation of
LRP6 signalosomes . . . . . . . . . . . 419
Takao Ono and
Daisuke Yamashita and
Tatsuya Hirano Condensin II initiates sister chromatid
resolution during S phase . . . . . . . 429
Kee K. Kim and
Joseph Nam and
Yoh-suke Mukouyama and
Sachiyo Kawamoto Rbfox3-regulated alternative splicing of
Numb promotes neuronal differentiation
during development . . . . . . . . . . . 443
J. Richard McIntosh and
Eileen O'Toole and
Kirill Zhudenkov and
Mary Morphew and
Cindi Schwartz and
Fazly I. Ataullakhanov and
Ekaterina L. Grishchuk Conserved and divergent features of
kinetochores and spindle microtubule
ends from five species . . . . . . . . . 459
Jose A. Martina and
Rosa Puertollano Rag GTPases mediate amino acid-dependent
recruitment of TFEB and MITF to
lysosomes . . . . . . . . . . . . . . . 475
Zamal Ahmed and
Chi-Chuan Lin and
Kin M. Suen and
Fernando A. Melo and
James A. Levitt and
Klaus Suhling and
John E. Ladbury Grb2 controls phosphorylation of FGFR2
by inhibiting receptor kinase and Shp2
phosphatase activity . . . . . . . . . . 493
Stefanie Kuhns and
Kerstin N. Schmidt and
Jürgen Reymann and
Daniel F. Gilbert and
Annett Neuner and
Birgit Hub and
Ricardo Carvalho and
Philipp Wiedemann and
Hanswalter Zentgraf and
Holger Erfle and
Ursula Klingmüller and
Michael Boutros and
Gislene Pereira The microtubule affinity regulating
kinase MARK4 promotes axoneme extension
during early ciliogenesis . . . . . . . 505
Davide Randazzo and
Emiliana Giacomello and
Stefania Lorenzini and
Daniela Rossi and
Enrico Pierantozzi and
Bert Blaauw and
Carlo Reggiani and
Stephan Lange and
Angela K. Peter and
Ju Chen and
Vincenzo Sorrentino Obscurin is required for
ankyrinB-dependent dystrophin
localization and sarcolemma integrity 523
Joachim Albers and
Johannes Keller and
Anke Baranowsky and
Frank Timo Beil and
Philip Catala-Lehnen and
Jochen Schulze and
Michael Amling and
Thorsten Schinke Canonical Wnt signaling inhibits
osteoclastogenesis independent of
osteoprotegerin . . . . . . . . . . . . 537
Ben Short Heat shock gene resides in a pore
neighborhood . . . . . . . . . . . . . . ??
Ben Short Breaking down Arp2/3 function . . . . . ??
Ben Short PEX26 takes the direct route . . . . . . ??
Ben Short Notochord vacuoles make a rod for the
vertebrate back . . . . . . . . . . . . 553
Caitlin Sedwick Martin Humphries: Attached to adhesion 554
Florencia Rago and
Iain M. Cheeseman The functions and consequences of force
at kinetochores . . . . . . . . . . . . 557
Kexi Yi and
Boris Rubinstein and
Jay R. Unruh and
Fengli Guo and
Brian D. Slaughter and
Rong Li Sequential actin-based pushing forces
drive meiosis I chromosome migration and
symmetry breaking in oocytes . . . . . . 567
Katherine E. Sloan and
Sandy Mattijssen and
Simon Lebaron and
David Tollervey and
Ger J. M. Pruijn and
Nicholas J. Watkins Both endonucleolytic and exonucleolytic
cleavage mediate ITS1 removal during
human ribosomal RNA processing . . . . . 577
Sabine Rohner and
Veronique Kalck and
Xuefei Wang and
Kohta Ikegami and
Jason D. Lieb and
Susan M. Gasser and
Peter Meister Promoter- and RNA polymerase
II-dependent hsp-16 gene association
with nuclear pores in
\bionameCaenorhabditis elegans . . . . . 589
Oliver Dreesen and
Alexandre Chojnowski and
Peh Fern Ong and
Tian Yun Zhao and
John E. Common and
Declan Lunny and
E. Birgitte Lane and
Shu Jin Lee and
Leah A. Vardy and
Colin L. Stewart and
Alan Colman Lamin B1 fluctuations have differential
effects on cellular proliferation and
senescence . . . . . . . . . . . . . . . 605
Elena Ingerman and
Jennifer Ying Hsiao and
R. Dyche Mullins Arp2\slash 3 complex ATP hydrolysis
promotes lamellipodial actin network
disassembly but is dispensable for
assembly . . . . . . . . . . . . . . . . 619
Junya Hayase and
Sachiko Kamakura and
Yuko Iwakiri and
Yoshihiro Yamaguchi and
Tomoko Izaki and
Takashi Ito and
Hideki Sumimoto The WD40 protein Morg1 facilitates
Par6--aPKC binding to Crb3 for apical
identity in epithelial cells . . . . . . 635
Yuichi Yagita and
Takahide Hiromasa and
Yukio Fujiki Tail-anchored PEX26 targets peroxisomes
via a PEX19-dependent and
TRC40-independent class I pathway . . . 651
Kathryn Ellis and
Jennifer Bagwell and
Michel Bagnat Notochord vacuoles are lysosome-related
organelles that function in axis and
spine morphogenesis . . . . . . . . . . 667
Bharat Joshi and
Michele Bastiani and
Scott S. Strugnell and
Cecile Boscher and
Robert G. Parton and
Ivan R. Nabi Phosphocaveolin-1 is a mechanotransducer
that induces caveola biogenesis via Egr1
transcriptional regulation . . . . . . . 681
Ben Short Oncogenes induce a reversal of
replication's fortunes . . . . . . . . . ??
Ben Short Misshapen orders an egg roll . . . . . . ??
Ben Short CUL4B keeps replication firing on all
cylinders . . . . . . . . . . . . . . . ??
Ben Short The plastic proteome . . . . . . . . . . 685
Caitlin Sedwick Jürgen Roth: Immunogold master . . . . . 686
Romain Levayer and
Eduardo Moreno Mechanisms of cell competition: Themes
and variations . . . . . . . . . . . . . 689
Kai J. Neelsen and
Isabella M. Y. Zanini and
Raquel Herrador and
Massimo Lopes Oncogenes induce genotoxic stress by
mitotic processing of unusual
replication intermediates . . . . . . . 699
Nathalie Jurisch-Yaksi and
Applonia J. Rose and
Huiqi Lu and
Tim Raemaekers and
Sebastian Munck and
Pieter Baatsen and
Veerle Baert and
Wendy Vermeire and
Suzie J. Scales and
Daphne Verleyen and
Roel Vandepoel and
Przemko Tylzanowski and
Emre Yaksi and
Thomy de Ravel and
H. Joseph Yost and
Guy Froyen and
Cammon B. Arrington and
Wim Annaert Rer1p maintains ciliary length and
signaling by regulating $ \gamma
$-secretase activity and Foxj1a levels 709
Lindsay Lewellyn and
Maureen Cetera and
Sally Horne-Badovinac Misshapen decreases integrin levels to
promote epithelial motility and planar
polarity in \bionameDrosophila . . . . . 721
Hongyu Zhao and
Yan G. Zhao and
Xingwei Wang and
Lanjun Xu and
Lin Miao and
Du Feng and
Quan Chen and
Attila L. Kovács and
Dongsheng Fan and
Hong Zhang Mice deficient in Epg5 exhibit selective
neuronal vulnerability to degeneration 731
Yongxin Zou and
Jun Mi and
Wenxing Wang and
Juanjuan Lu and
Wei Zhao and
Zhaojian Liu and
Huili Hu and
Yang Yang and
Xiaoxing Gao and
Baichun Jiang and
Changshun Shao and
Yaoqin Gong CUL4B promotes replication licensing by
up-regulating the CDK2--CDC6 cascade . . 743
Andrew D. Stephens and
Rachel A. Haggerty and
Paula A. Vasquez and
Leandra Vicci and
Chloe E. Snider and
Fu Shi and
Cory Quammen and
Christopher Mullins and
Julian Haase and
Russell M. Taylor and
Jolien S. Verdaasdonk and
Michael R. Falvo and
Yuan Jin and
M. Gregory Forest and
Kerry Bloom Pericentric chromatin loops function as
a nonlinear spring in mitotic force
balance . . . . . . . . . . . . . . . . 757
Mei Zhu and
Florian Settele and
Sachin Kotak and
Luis Sanchez-Pulido and
Lena Ehret and
Chris P. Ponting and
Pierre Gönczy and
Ingrid Hoffmann MISP is a novel Plk1 substrate required
for proper spindle orientation and
mitotic progression . . . . . . . . . . 773
Anthony J. Morgan and
Lianne C. Davis and
Siegfried K. T. Y. Wagner and
Alexander M. Lewis and
John Parrington and
Grant C. Churchill and
Antony Galione Bidirectional Ca$^{2+}$ signaling occurs
between the endoplasmic reticulum and
acidic organelles . . . . . . . . . . . 789
Ke Zhang and
Zhihong Li and
Manish Jaiswal and
Vafa Bayat and
Bo Xiong and
Hector Sandoval and
Wu-Lin Charng and
Gabriela David and
Claire Haueter and
Shinya Yamamoto and
Brett H. Graham and
Hugo J. Bellen The C8ORF38 homologue Sicily is a
cytosolic chaperone for a mitochondrial
complex I subunit . . . . . . . . . . . 807
Wen-Fang Xia and
Fu-Lei Tang and
Lei Xiong and
Shan Xiong and
Ji-Ung Jung and
Dae-Hoon Lee and
Xing-Sheng Li and
Xu Feng and
Lin Mei and
Wen-Cheng Xiong Vps35 loss promotes hyperresorptive
osteoclastogenesis and osteoporosis via
sustained RANKL signaling . . . . . . . 821
Michal Breker and
Melissa Gymrek and
Maya Schuldiner A novel single-cell screening platform
reveals proteome plasticity during yeast
stress responses . . . . . . . . . . . . 839
Daniele Catalucci and
Deng-Hong Zhang and
Jaime DeSantiago and
Franck Aimond and
Guillaume Barbara and
Jean Chemin and
Désiré Bonci and
Eckard Picht and
Francesca Rusconi and
Nancy D. Dalton and
Kirk L. Peterson and
Sylvain Richard and
Donald M. Bers and
Joan Heller Brown and
Gianluigi Condorelli Akt regulates L-type Ca$^{2+}$ channel
activity by modulating Ca$_v$ $ \alpha
$1 protein stability . . . . . . . . . . 851
Arnab Sen and
Zsanett Nagy-Zsvér-Vadas and
Michael P. Krahn Drosophila PATJ supports adherens
junction stability by modulating Myosin
light chain activity . . . . . . . . . . 853
Mitch Leslie FANCJ lets chromatin stay true . . . . . ??
Mitch Leslie STT3B gets the tip . . . . . . . . . . . ??
Mitch Leslie Actin draws a cadherin crowd . . . . . . ??
Mitch Leslie Rise and fall of the kinetochore . . . . 3
Caitlin Sedwick Sandhya Koushika: Building new models
and communities . . . . . . . . . . . . 4
Mike Rossner New mandates? No problem for The
Rockefeller University Press . . . . . . 7
Robin M. Ricke and
Jan M. van Deursen Aneuploidy in health, disease, and aging 11
Karen E. Gascoigne and
Iain M. Cheeseman CDK-dependent phosphorylation and
nuclear exclusion coordinately control
kinetochore assembly state . . . . . . . 23
Rebekka A. Schwab and
Jadwiga Nieminuszczy and
Kazuo Shin-ya and
Wojciech Niedzwiedz FANCJ couples replication past natural
fork barriers with maintenance of
chromatin structure . . . . . . . . . . 33
Daniel W. Buster and
Scott G. Daniel and
Huy Q. Nguyen and
Sarah L. Windler and
Lara C. Skwarek and
Maureen Peterson and
Meredith Roberts and
Joy H. Meserve and
Tom Hartl and
Joseph E. Klebba and
David Bilder and
Giovanni Bosco and
Gregory C. Rogers SCF$^{\rm Slimb}$ ubiquitin ligase
suppresses condensin II-mediated nuclear
reorganization by degrading Cap--H2 . . 49
David Reboutier and
Marie-Béreng\`ere Troadec and
Jean-Yves Cremet and
Lucie Chauvin and
Vincent Guen and
Patrick Salaun and
Claude Prigent Aurora A is involved in central spindle
assembly through phosphorylation of Ser
19 in P150Glued . . . . . . . . . . . . 65
Shiteshu Shrimal and
Steven F. Trueman and
Reid Gilmore Extreme C-terminal sites are
posttranslocationally glycosylated by
the STT3B isoform of the OST . . . . . . 81
Arun T. John Peter and
Jens Lachmann and
Meenakshi Rana and
Madeleine Bunge and
Margarita Cabrera and
Christian Ungermann The BLOC-1 complex promotes endosomal
maturation by recruiting the Rab5
GTPase-activating protein Msb3 . . . . . 97
Long Lin and
Peiguo Yang and
Xinxin Huang and
Hui Zhang and
Qun Lu and
Hong Zhang The scaffold protein EPG-7 links
cargo--receptor complexes with the
autophagic assembly machinery . . . . . 113
Soonjin Hong and
Regina B. Troyanovsky and
Sergey M. Troyanovsky Binding to F-actin guides cadherin
cluster assembly, stability, and
movement . . . . . . . . . . . . . . . . 131
Tharan Srikumar and
Megan C. Lewicki and
Michael Costanzo and
Johnny M. Tkach and
Harm van Bakel and
Kyle Tsui and
Erica S. Johnson and
Grant W. Brown and
Brenda J. Andrews and
Charles Boone and
Guri Giaever and
Corey Nislow and
Brian Raught Global analysis of SUMO chain function
reveals multiple roles in chromatin
regulation . . . . . . . . . . . . . . . 145
Yanmei Qi and
Xiaoxiang Tian and
Jie Liu and
Yaling Han and
Alan M. Graham and
M. Celeste Simon and
Josef M. Penninger and
Peter Carmeliet and
Shaohua Li Bnip3 and AIF cooperate to induce
apoptosis and cavitation during
epithelial morphogenesis . . . . . . . . 165
Mikito Takefuji and
Marcus Krüger and
Kishor K. Sivaraj and
Kozo Kaibuchi and
Stefan Offermanns and
Nina Wettschureck RhoGEF12 controls cardiac remodeling by
integrating G protein-- and
integrin-dependent signaling cascades ??
Inge Van de Walle and
Els Waegemans and
Jelle De Medts and
Greet De Smet and
Magda De Smedt and
Sylvia Snauwaert and
Bart Vandekerckhove and
Tessa Kerre and
Georges Leclercq and
Jean Plum and
Thomas Gridley and
Tao Wang and
Ute Koch and
Freddy Radtke and
Tom Taghon Specific Notch receptor--ligand
interactions control human TCR-ab/gd
development by inducing differential
Notch signal strength . . . . . . . . . ??
Ben Short Frog oocytes evade the checkpoint . . . ??
Ben Short The BBSome's export duty . . . . . . . . ??
Ben Short Hypoxia takes invadopodia up a Notch . . ??
Ben Short Setting an immuno--TRAP for PML nuclear
bodies . . . . . . . . . . . . . . . . . 169
Caitlin Sedwick Margaret Gardel: At the interface of
physics and biology . . . . . . . . . . 170
Stephen M. King A solid-state control system for
dynein-based ciliary/flagellar motility 173
Ivana Primorac and
Andrea Musacchio \bionamePanta rhei: The APC/C at steady
state . . . . . . . . . . . . . . . . . 177
Hua Shao and
Ruizhen Li and
Chunqi Ma and
Eric Chen and
X. Johné Liu Xenopus oocyte meiosis lacks spindle
assembly checkpoint control . . . . . . 191
Jonne A. Raaijmakers and
Marvin E. Tanenbaum and
René H. Medema Systematic dissection of dynein
regulators in mitosis . . . . . . . . . 201
Wilco Nijenhuis and
Eleonore von Castelmur and
Dene Littler and
Valeria De Marco and
Eelco Tromer and
Mathijs Vleugel and
Maria H. J. van Osch and
Berend Snel and
Anastassis Perrakis and
Geert J. P. L. Kops A TPR domain--containing N-terminal
module of MPS1 is required for its
kinetochore localization by Aurora B . . 217
Lymarie Maldonado-Báez and
Nelson B. Cole and
Helmut Krämer and
Julie G. Donaldson Microtubule-dependent endosomal sorting
of clathrin-independent cargo by Hook1 233
Karl F. Lechtreck and
Jason M. Brown and
Julio L. Sampaio and
Julie M. Craft and
Andrej Shevchenko and
James E. Evans and
George B. Witman Cycling of the signaling protein
phospholipase D through cilia requires
the BBSome only for the export phase . . 249
Ryosuke Yamamoto and
Kangkang Song and
Haru-aki Yanagisawa and
Laura Fox and
Toshiki Yagi and
Maureen Wirschell and
Masafumi Hirono and
Ritsu Kamiya and
Daniela Nicastro and
Winfield S. Sale The MIA complex is a conserved and novel
dynein regulator essential for normal
ciliary motility . . . . . . . . . . . . 263
Begoña Díaz and
Angela Yuen and
Shinji Iizuka and
Shigeki Higashiyama and
Sara A. Courtneidge Notch increases the shedding of HB--EGF
by ADAM12 to potentiate invadopodia
formation in hypoxia . . . . . . . . . . 279
Venus Thomanetz and
Nico Angliker and
Dimitri Cloëtta and
Regula M. Lustenberger and
Manuel Schweighauser and
Filippo Oliveri and
Noboru Suzuki and
Markus A. Rüegg Ablation of the mTORC2 component rictor
in brain or Purkinje cells affects size
and neuron morphology . . . . . . . . . 293
Anthony I. Romer and
Jagmohan Singh and
Satish Rattan and
Robert S. Krauss Smooth muscle fascicular reorientation
is required for esophageal morphogenesis
and dependent on Cdo . . . . . . . . . . 309
Reagan W. Ching and
Kashif Ahmed and
Paul C. Boutros and
Linda Z. Penn and
David P. Bazett-Jones Identifying gene locus associations with
promyelocytic leukemia nuclear bodies
using immuno--TRAP . . . . . . . . . . . 325
Edward Avezov and
Benedict C. S. Cross and
Gabriele S. Kaminski Schierle and
Mikael Winters and
Heather P. Harding and
Eduardo Pinho Melo and
Clemens F. Kaminski and
David Ron Lifetime imaging of a fluorescent
protein sensor reveals surprising
stability of ER thiol redox . . . . . . 337
Mitch Leslie FANCJ lets chromatin stay true . . . . . 351
Michal Breker and
Melissa Gymrek and
Maya Schuldiner A novel single-cell screening platform
reveals proteome plasticity during yeast
stress responses . . . . . . . . . . . . 353
Ben Short Fewer forks make faster progress . . . . ??
Ben Short Bub3's function doesn't stop at the
checkpoint . . . . . . . . . . . . . . . ??
Ben Short EphA2 cleavage helps tumor cells go it
alone . . . . . . . . . . . . . . . . . ??
Ben Short Sanpodo seals precursors' fate . . . . . 357
Caitlin Sedwick Carla Koehler: Small TIMs are a big deal 358
Yun R. Li and
Oliver D. King and
James Shorter and
Aaron D. Gitler Stress granules as crucibles of ALS
pathogenesis . . . . . . . . . . . . . . 361
Yuan Zhong and
Tittu Nellimoottil and
Jared M. Peace and
Simon R. V. Knott and
Sandra K. Villwock and
Janis M. Yee and
Jeffrey M. Jancuska and
Sanket Rege and
Marianne Tecklenburg and
Robert A. Sclafani and
Simon Tavaré and
Oscar M. Aparicio The level of origin firing inversely
affects the rate of replication fork
progression . . . . . . . . . . . . . . 373
Sara Morais da Silva and
Tatiana Moutinho-Santos and
Claudio E. Sunkel A tumor suppressor role of the Bub3
spindle checkpoint protein after
apoptosis inhibition . . . . . . . . . . 385
Valérie Bergoglio and
Anne-Sophie Boyer and
Erin Walsh and
Valeria Naim and
Gaëlle Legube and
Marietta Y. W. T. Lee and
Laurie Rey and
Filippo Rosselli and
Christophe Cazaux and
Kristin A. Eckert and
Jean-Sébastien Hoffmann DNA synthesis by Pol $ \eta $ promotes
fragile site stability by preventing
under-replicated DNA in mitosis . . . . 395
An Zeng and
Yong-Qin Li and
Chen Wang and
Xiao-Shuai Han and
Ge Li and
Jian-Yong Wang and
Dang-Sheng Li and
Yong-Wen Qin and
Yufang Shi and
Gary Brewer and
Qing Jing Heterochromatin protein 1 promotes
self-renewal and triggers regenerative
proliferation in adult stem cells . . . 409
Amelia U. Contreras and
Yohannes Mebratu and
Monica Delgado and
Gilbert Montano and
Chien-an A. Hu and
Stefan W. Ryter and
Augustine M. K. Choi and
Yuting Lin and
Jialing Xiang and
Hitendra Chand and
Yohannes Tesfaigzi Deacetylation of p53 induces autophagy
by suppressing Bmf expression . . . . . 427
Alok Upadhyay and
Vasundhara Kandachar and
Diana Zitserman and
Xin Tong and
Fabrice Roegiers Sanpodo controls sensory organ precursor
fate by directing Notch trafficking and
binding $ \gamma $-secretase . . . . . . 439
Roberta Martinelli and
Masataka Kamei and
Peter T. Sage and
Ramiro Massol and
Laya Varghese and
Tracey Sciuto and
Mourad Toporsian and
Ann M. Dvorak and
Tomas Kirchhausen and
Timothy A. Springer and
Christopher V. Carman Release of cellular tension signals
self-restorative ventral lamellipodia to
heal barrier micro-wounds . . . . . . . 449
Nami Sugiyama and
Erika Gucciardo and
Olga Tatti and
Markku Varjosalo and
Marko Hyytiäinen and
Matthias Gstaiger and
Kaisa Lehti EphA2 cleavage by MT1-MMP triggers
single cancer cell invasion via
homotypic cell repulsion . . . . . . . . 467
Clifford V. Harding and
John E. Heuser and
Philip D. Stahl Exosomes: Looking back three decades and
into the future . . . . . . . . . . . . 485
David Reboutier and
Marie-Béreng\`ere Troadec and
Jean-Yves Cremet and
Lucie Chauvin and
Vincent Guen and
Patrick Salaun and
Claude Prigent Aurora A is involved in central spindle
assembly through phosphorylation of Ser
19 in P150Glued . . . . . . . . . . . . 487
Mitch Leslie Progerin guilty of size discrimination ??
Mitch Leslie Why metaphase chromosomes wander . . . . ??
Mitch Leslie Three's not a crowd for actin nucleators ??
Mitch Leslie Making short work of p53 . . . . . . . . 491
Caitlin Sedwick Victor Ambros: The broad scope of
microRNAs . . . . . . . . . . . . . . . 492
Helmut Krämer Route to destruction: Autophagosomes
SNARE lysosomes . . . . . . . . . . . . 495
Fedik Rahimov and
Louis M. Kunkel Cellular and molecular mechanisms
underlying muscular dystrophy . . . . . 499
Petra Kleiblova and
Indra A. Shaltiel and
Jan Benada and
Jan ev\vcík and
So\vna Pechá\vcková and
Petr Pohlreich and
Emile E. Voest and
Pavel Dundr and
Jiri Bartek and
Zdenek Kleibl and
René H. Medema and
Libor Macurek Gain-of-function mutations of PPM1D/Wip1
impair the p53-dependent G1 checkpoint 511
Mary Rose Bufalino and
Brian DeVeale and
Derek van der Kooy The asymmetric segregation of damaged
proteins is stem cell--type dependent 523
Szabolcs Takáts and
Péter Nagy and
Ágnes Varga and
Karolina Pircs and
Manuéla Kárpáti and
Kata Varga and
Attila L. Kovács and
Krisztina Heged\Hus and
Gábor Juhász Autophagosomal Syntaxin17-dependent
lysosomal degradation maintains neuronal
function in \bionameDrosophila . . . . . 531
Chelsi J. Snow and
Ashraf Dar and
Anindya Dutta and
Ralph H. Kehlenbach and
Bryce M. Paschal Defective nuclear import of Tpr in
Progeria reflects the Ran sensitivity of
large cargo transport . . . . . . . . . 541
Elsa Kress and
Françoise Schwager and
René Holtackers and
Jonas Seiler and
François Prodon and
Esther Zanin and
Annika Eiteneuer and
Mika Toya and
Asako Sugimoto and
Hemmo Meyer and
Patrick Meraldi and
Monica Gotta The UBXN-2/p37/p47 adaptors of
CDC-48/p97 regulate mitosis by limiting
the centrosomal recruitment of Aurora A 559
Gul Civelekoglu-Scholey and
Bin He and
Muyao Shen and
Xiaohu Wan and
Emanuele Roscioli and
Brent Bowden and
Daniela Cimini Dynamic bonds and polar ejection force
distribution explain kinetochore
oscillations in PtK1 cells . . . . . . . 577
Brian R. Graziano and
Erin M. Jonasson and
Jessica G. Pullen and
Christopher J. Gould and
Bruce L. Goode Ligand-induced activation of a
formin--NPF pair leads to collaborative
actin nucleation . . . . . . . . . . . . 595
Albert R. Davalos and
Misako Kawahara and
Gautam K. Malhotra and
Nicholas Schaum and
Jiahao Huang and
Urvi Ved and
Christian M. Beausejour and
Jean-Philippe Coppe and
Francis Rodier and
Judith Campisi p53-dependent release of Alarmin HMGB1
is a central mediator of senescent
phenotypes . . . . . . . . . . . . . . . 613
Daniel Chen and
Emily S. Gibson and
Matthew J. Kennedy A light-triggered protein secretion
system . . . . . . . . . . . . . . . . . 631
Gregory Bix and
Jian Fu and
Eva M. Gonzalez and
Laura Macro and
Amy Barker and
Shelly Campbell and
Mary M. Zutter and
Samuel A. Santoro and
Jiyeun K. Kim and
Magnus Höök and
Charles C. Reed and
Renato V. Iozzo Endorepellin causes endothelial cell
disassembly of actin cytoskeleton and
focal adhesions through $ \alpha $2$
\beta $1 integrin . . . . . . . . . . . 641
Molly Brunner and
Angélique Millon-Frémillon and
Genevieve Chevalier and
Inaam A. Nakchbandi and
Deane Mosher and
Marc R. Block and
Corinne Albig\`es-Rizo and
Daniel Bouvard Osteoblast mineralization requires $
\beta $1 integrin/ICAP-$1$-dependent
fibronectin deposition . . . . . . . . . 643
Ben Short Low pH puts proteasomes in storage . . . ??
Ben Short EB3 helps daughter cells spread their
wings . . . . . . . . . . . . . . . . . ??
Ben Short Hif-1$ \alpha $ provides a Twist to
neural crest migration . . . . . . . . . ??
Ben Short Stem cells get a cholesterol test . . . 647
Caitlin Sedwick Alpha Yap: Cadherins hold it all
together . . . . . . . . . . . . . . . . 648
Tom Misteli Eliminating the impact of the Impact
Factor . . . . . . . . . . . . . . . . . 651
Soizic Riche and
Melissa Zouak and
Françoise Argoul and
Alain Arneodo and
Jacques Pecreaux and
Marie Delattre Evolutionary comparisons reveal a
positional switch for spindle pole
oscillations in \bionameCaenorhabditis
embryos . . . . . . . . . . . . . . . . 653
Lee Zeev Peters and
Rotem Hazan and
Michal Breker and
Maya Schuldiner and
Shay Ben-Aroya Formation and dissociation of proteasome
storage granules are regulated by
cytosolic pH . . . . . . . . . . . . . . 663
Felix Rivera-Molina and
Derek Toomre Live-cell imaging of exocyst links its
spatiotemporal dynamics to various
stages of vesicle fusion . . . . . . . . 673
Cornelia Kröger and
Fanny Loschke and
Nicole Schwarz and
Reinhard Windoffer and
Rudolf E. Leube and
Thomas M. Magin Keratins control intercellular adhesion
involving PKC-$ \alpha $-mediated
desmoplakin phosphorylation . . . . . . 681
Colleen R. Reczek and
Matthias Szabolcs and
Jeremy M. Stark and
Thomas Ludwig and
Richard Baer The interaction between CtIP and BRCA1
is not essential for resection-mediated
DNA repair or tumor suppression . . . . 693
Jorge G. Ferreira and
António J. Pereira and
Anna Akhmanova and
Helder Maiato Aurora B spatially regulates EB3
phosphorylation to coordinate daughter
cell adhesion with cytokinesis . . . . . 709
Rubén Fernández-Busnadiego and
Shoh Asano and
Ana-Maria Oprisoreanu and
Eri Sakata and
Michael Doengi and
Zdravko Kochovski and
Magdalena Zürner and
Valentin Stein and
Susanne Schoch and
Wolfgang Baumeister and
Vladan Lu\vci\'c Cryo--electron tomography reveals a
critical role of RIM1$ \alpha $ in
synaptic vesicle tethering . . . . . . . 725
Tiffiney R. Hartman and
Todd I. Strochlic and
Yingbiao Ji and
Daniel Zinshteyn and
Alana M. O'Reilly Diet controls \bionameDrosophila
follicle stem cell proliferation via
Hedgehog sequestration and release . . . 741
Elias H. Barriga and
Patrick H. Maxwell and
Ariel E. Reyes and
Roberto Mayor The hypoxia factor Hif-1$ \alpha $
controls neural crest chemotaxis and
epithelial to mesenchymal transition . . 759
Fabien Vanden Abeele and
Gabriel Bidaux and
Dmitri Gordienko and
Benjamin Beck and
Yuri V. Panchin and
Ancha V. Baranova and
Dmitry V. Ivanov and
Roman Skryma and
Natalia Prevarskaya Functional implications of calcium
permeability of the channel formed by
pannexin 1 . . . . . . . . . . . . . . . 777
Mitch Leslie Hippo throws its weight behind migrating
cells . . . . . . . . . . . . . . . . . ??
Mitch Leslie E-cadherin stops embryonic cells from
crossing borders . . . . . . . . . . . . ??
Mitch Leslie Bone morphogenetic protein guts it out ??
Mitch Leslie Means to an end . . . . . . . . . . . . 781
Caitlin Sedwick Yukiko Yamashita: The centrosomes get
there first . . . . . . . . . . . . . . 782
Kellie R. Machlus and
Joseph E. Italiano The incredible journey: From
megakaryocyte development to platelet
formation . . . . . . . . . . . . . . . 785
Sara L. Poulsen and
Rebecca K. Hansen and
Sebastian A. Wagner and
Loes van Cuijk and
Gijsbert J. van Belle and
Werner Streicher and
Mats Wikström and
Chunaram Choudhary and
Adriaan B. Houtsmuller and
Jurgen A. Marteijn and
Simon Bekker-Jensen and
Niels Mailand RNF111/Arkadia is a SUMO-targeted
ubiquitin ligase that facilitates the
DNA damage response . . . . . . . . . . 797
Jacob G. Kirkland and
Rohinton T. Kamakaka Long-range heterochromatin association
is mediated by silencing and
double-strand DNA break repair proteins 809
Géraldine Laloux and
Christine Jacobs-Wagner Spatiotemporal control of PopZ
localization through cell cycle--coupled
multimerization . . . . . . . . . . . . 827
Noel Lianga and
Elizabeth C. Williams and
Erin K. Kennedy and
Carole Doré and
Sophie Pilon and
Stéphanie L. Girard and
Jean-Sebastien Deneault and
Adam D. Rudner A Wee1 checkpoint inhibits anaphase
onset . . . . . . . . . . . . . . . . . 843
Yunhao Liu and
Caitlin Collins and
William B. Kiosses and
Ann M. Murray and
Monika Joshi and
Tyson R. Shepherd and
Ernesto J. Fuentes and
Ellie Tzima A novel pathway spatiotemporally
activates Rac1 and redox signaling in
response to fluid shear stress . . . . . 863
Eliana P. Lucas and
Ichha Khanal and
Pedro Gaspar and
Georgina C. Fletcher and
Cedric Polesello and
Nicolas Tapon and
Barry J. Thompson The Hippo pathway polarizes the actin
cytoskeleton during collective migration
of \bionameDrosophila border cells . . . 875
Natalia A. Bulgakova and
Ilya Grigoriev and
Alpha S. Yap and
Anna Akhmanova and
Nicholas H. Brown Dynamic microtubules produce an
asymmetric E--cadherin--Bazooka complex
to maintain segment boundaries . . . . . 887
Elliott J. Hagedorn and
Joshua W. Ziel and
Meghan A. Morrissey and
Lara M. Linden and
Zheng Wang and
Qiuyi Chi and
Sam A. Johnson and
David R. Sherwood The netrin receptor DCC focuses
invadopodia-driven basement membrane
transmigration in vivo . . . . . . . . . 903
Samantha A. Spangler and
Sabine K. Schmitz and
Josta T. Kevenaar and
Esther de Graaff and
Heidi de Wit and
Jeroen Demmers and
Ruud F. Toonen and
Casper C. Hoogenraad Liprin-$ \alpha $2 promotes the
presynaptic recruitment and turnover of
RIM1/CASK to facilitate synaptic
transmission . . . . . . . . . . . . . . 915
Jooyeon Woo and
Seok-Kyu Kwon and
Jungyong Nam and
Seungwon Choi and
Hideto Takahashi and
Dilja Krueger and
Joohyun Park and
Yeunkum Lee and
Jin Young Bae and
Dongmin Lee and
Jaewon Ko and
Hyun Kim and
Myoung-Hwan Kim and
Yong Chul Bae and
Sunghoe Chang and
Ann Marie Craig and
Eunjoon Kim The adhesion protein IgSF9b is coupled
to neuroligin 2 via S--SCAM to promote
inhibitory synapse development . . . . . 929
Zheng Guo and
Ian Driver and
Benjamin Ohlstein Injury-induced BMP signaling negatively
regulates \bionameDrosophila midgut
homeostasis . . . . . . . . . . . . . . 945
Ben Short A potato virus makes its move . . . . . ??
Ben Short A mature view of the Golgi . . . . . . . ??
Ben Short Sequestration puts Drp1 on furlough . . ??
Ben Short Testing the limits of cell migration . . 965
Caitlin Sedwick John Briggs: a closer look at HIV and
coated vesicles . . . . . . . . . . . . 966
Roberto Weigert and
Natalie Porat-Shliom and
Panomwat Amornphimoltham Imaging cell biology in live animals:
Ready for prime time . . . . . . . . . . 969
Jens Tilsner and
Olga Linnik and
Marion Louveaux and
Ian M. Roberts and
Sean N. Chapman and
Karl J. Oparka Replication and trafficking of a plant
virus are coupled at the entrances of
plasmodesmata . . . . . . . . . . . . . 981
Grzegorz Nalepa and
Jill Barnholtz-Sloan and
Rikki Enzor and
Dilip Dey and
Ying He and
Jeff R. Gehlhausen and
Amalia S. Lehmann and
Su-Jung Park and
Yanzhu Yang and
Xianlin Yang and
Shi Chen and
Xiaowei Guan and
Yanwen Chen and
Jamie Renbarger and
Feng-Chun Yang and
Luis F. Parada and
Wade Clapp The tumor suppressor CDKN3 controls
mitosis . . . . . . . . . . . . . . . . 997
Linda Clijsters and
Janneke Ogink and
Rob Wolthuis The spindle checkpoint, APC/C$^{\rm
Cdc20}$, and APC/C$^{\rm Cdh1}$ play
distinct roles in connecting mitosis to
S phase . . . . . . . . . . . . . . . . 1013
Riccardo Rizzo and
Seetharaman Parashuraman and
Peppino Mirabelli and
Claudia Puri and
John Lucocq and
Alberto Luini The dynamics of engineered resident
proteins in the mammalian Golgi complex
relies on cisternal maturation . . . . . 1027
Stefan Strack and
Theodore J. Wilson and
J. Thomas Cribbs Cyclin-dependent kinases regulate
splice-specific targeting of
dynamin-related protein 1 to
microtubules . . . . . . . . . . . . . . 1037
Jieqing Zhu and
Jianghai Zhu and
Timothy A. Springer Complete integrin headpiece opening in
eight steps . . . . . . . . . . . . . . 1053
Katarina Wolf and
Mariska te Lindert and
Marina Krause and
Stephanie Alexander and
Joost te Riet and
Amanda L. Willis and
Robert M. Hoffman and
Carl G. Figdor and
Stephen J. Weiss and
Peter Friedl Physical limits of cell migration:
Control by ECM space and nuclear
deformation and tuning by proteolysis
and traction force . . . . . . . . . . . 1069
Oxana E. Nekrasova and
Evangeline V. Amargo and
William O. Smith and
Jing Chen and
Geri E. Kreitzer and
Kathleen J. Green Desmosomal cadherins utilize distinct
kinesins for assembly into desmosomes 1085
Yeon-Tae Jeong and
Mario Rossi and
Lukas Cermak and
Anita Saraf and
Laurence Florens and
Michael P. Washburn and
Patrick Sung and
Carl L. Schildkraut and
Michele Pagano FBH1 promotes DNA double-strand breakage
and apoptosis in response to DNA
replication stress . . . . . . . . . . . 1087
Mitch Leslie Catching augmin in the act . . . . . . . ??
Mitch Leslie $ \beta $-Catenin solidifies tight
junctions in the skin . . . . . . . . . ??
Mitch Leslie SSX2IP helps the centrosome grow up . . ??
Mitch Leslie A lifeline for lipid rafts? . . . . . . 3
Caitlin Sedwick Didier Stainier: How function follows
form . . . . . . . . . . . . . . . . . . 4
Inge Kepert and
Michael A. Kiebler MoniTORing neuronal excitability at the
synapse . . . . . . . . . . . . . . . . 7
Darren J. Baker and
John M. Sedivy Probing the depths of cellular
senescence . . . . . . . . . . . . . . . 11
Masahide Kikkawa Big steps toward understanding dynein 15
Tomoko Kamasaki and
Eileen O'Toole and
Shigeo Kita and
Masako Osumi and
Jiro Usukura and
J. Richard McIntosh and
Gohta Goshima Augmin-dependent microtubule nucleation
at microtubule walls in the spindle . . 25
Alexandre Toulmay and
William A. Prinz Direct imaging reveals stable,
micrometer-scale lipid domains that
segregate proteins in live cells . . . . 35
Samriddha Ray and
Henry P. Foote and
Terry Lechler $ \beta $-Catenin protects the epidermis
from mechanical stresses . . . . . . . . 45
Natasha M. Sosanya and
Peggy P. C. Huang and
Luisa P. Cacheaux and
Chun Jung Chen and
Kathleen Nguyen and
Nora I. Perrone-Bizzozero and
Kimberly F. Raab-Graham Degradation of high affinity HuD targets
releases Kv1.1 mRNA from miR-129
repression by mTORC1 . . . . . . . . . . 53
Archana Jha and
Malini Ahuja and
József Maléth and
Claudia M. Moreno and
Joseph P. Yuan and
Min Seuk Kim and
Shmuel Muallem The STIM1 CTID domain determines access
of SARAF to SOAR to regulate Orai1
channel function . . . . . . . . . . . . 71
Felix Bärenz and
Daigo Inoue and
Hideki Yokoyama and
Justus Tegha-Dunghu and
Stephanie Freiss and
Stefanie Draeger and
Dmytro Mayilo and
Ivana Cado and
Sabine Merker and
Maren Klinger and
Burkhard Hoeckendorf and
Sahra Pilz and
Kerstin Hupfeld and
Herbert Steinbeisser and
Holger Lorenz and
Thomas Ruppert and
Joachim Wittbrodt and
Oliver J. Gruss The centriolar satellite protein SSX2IP
promotes centrosome maturation . . . . . 81
Guangzuo Luo and
Jian Zhang and
Francis C. Luca and
Wei Guo Mitotic phosphorylation of Exo84
disrupts exocyst assembly and arrests
cell growth . . . . . . . . . . . . . . 97
Mehul Shah and
Oscar Y. Baterina and
Vanessa Taupin and
Marilyn G. Farquhar ARH directs megalin to the endocytic
recycling compartment to regulate its
proteolysis and gene expression . . . . 113
Andre Ivanov and
Jeff Pawlikowski and
Indrani Manoharan and
John van Tuyn and
David M. Nelson and
Taranjit Singh Rai and
Parisha P. Shah and
Graeme Hewitt and
Viktor I. Korolchuk and
Joao F. Passos and
Hong Wu and
Shelley L. Berger and
Peter D. Adams Lysosome-mediated processing of
chromatin in senescence . . . . . . . . 129
Yuko Fukata and
Ariane Dimitrov and
Gaelle Boncompain and
Ole Vielemeyer and
Franck Perez and
Masaki Fukata Local palmitoylation cycles define
activity-regulated postsynaptic
subdomains . . . . . . . . . . . . . . . 145
Ingo Thievessen and
Peter M. Thompson and
Sylvain Berlemont and
Karen M. Plevock and
Sergey V. Plotnikov and
Alice Zemljic-Harpf and
Robert S. Ross and
Michael W. Davidson and
Gaudenz Danuser and
Sharon L. Campbell and
Clare M. Waterman Vinculin--actin interaction couples
actin retrograde flow to focal
adhesions, but is dispensable for focal
adhesion growth . . . . . . . . . . . . 163
Kohei Yamamizu and
Taichi Matsunaga and
Hideki Uosaki and
Hiroyuki Fukushima and
Shiori Katayama and
Mina Hiraoka-Kanie and
Kohnosuke Mitani and
Jun K. Yamashita Convergence of Notch and $ \beta
$-catenin signaling induces arterial
fate in vascular progenitors . . . . . . 179
Ben Short CDK1 makes the meiotic spindle wait . . ??
Ben Short Moving the Greatwall . . . . . . . . . . ??
Ben Short Epithelia restored by healing waves . . ??
Ben Short Syntaphilin puts the brakes on axonal
mitochondria . . . . . . . . . . . . . . 183
Caitlin Sedwick Suzanne Eaton: The beautiful logic of
development . . . . . . . . . . . . . . 184
Mohan K. Balasubramanian and
Evelyn Yaqiong Tao Timing it right: Precise ON/OFF switches
for Rho1 and Cdc42 GTPases in
cytokinesis . . . . . . . . . . . . . . 187
Francis A. Barr Rab GTPases and membrane identity:
Causal or inconsequential? . . . . . . . 191
Benjamin Albert and
Julien Mathon and
Ashutosh Shukla and
Hicham Saad and
Christophe Normand and
Isabelle Léger-Silvestre and
David Villa and
Alain Kamgoue and
Julien Mozziconacci and
Hua Wong and
Christophe Zimmer and
Purnima Bhargava and
Aurélien Bancaud and
Olivier Gadal Systematic characterization of the
conformation and dynamics of budding
yeast chromosome XII . . . . . . . . . . 201
Yi-Nan Lin and
Chien-Ting Wu and
Yu-Chih Lin and
Wen-Bin Hsu and
Chieh-Ju C. Tang and
Ching-Wen Chang and
Tang K. Tang CEP120 interacts with CPAP and
positively regulates centriole
elongation . . . . . . . . . . . . . . . 211
Olga Davydenko and
Richard M. Schultz and
Michael A. Lampson Increased CDK1 activity determines the
timing of kinetochore-microtubule
attachments in meiosis I . . . . . . . . 221
Benjamin D. Atkins and
Satoshi Yoshida and
Koji Saito and
Chi-Fang Wu and
Daniel J. Lew and
David Pellman Inhibition of Cdc42 during mitotic exit
is required for cytokinesis . . . . . . 231
Yuichi Wakana and
Julien Villeneuve and
Josse van Galen and
David Cruz-Garcia and
Mitsuo Tagaya and
Vivek Malhotra Kinesin-5/Eg5 is important for transport
of CARTS from the trans-Golgi network to
the cell surface . . . . . . . . . . . . 241
Sara Solinet and
Kazi Mahmud and
Shannon F. Stewman and
Khaled Ben El Kadhi and
Barbara Decelle and
Lama Talje and
Ao Ma and
Benjamin H. Kwok and
Sébastien Carreno The actin-binding ERM protein Moesin
binds to and stabilizes microtubules at
the cell cortex . . . . . . . . . . . . 251
Todd Schoborg and
Ryan Rickels and
Josh Barrios and
Mariano Labrador Chromatin insulator bodies are nuclear
structures that form in response to
osmotic stress and cell death . . . . . 261
Peng Wang and
Jacob A. Galan and
Karine Normandin and
Éric Bonneil and
Gilles R. Hickson and
Philippe P. Roux and
Pierre Thibault and
Vincent Archambault Cell cycle regulation of Greatwall
kinase nuclear localization facilitates
mitotic progression . . . . . . . . . . 277
Inai Park and
Hae-ock Lee and
Eunhee Choi and
Yoo-Kyung Lee and
Mi-Sun Kwon and
Jaewon Min and
Pil-Gu Park and
Seonju Lee and
Young-Yun Kong and
Gyungyub Gong and
Hyunsook Lee Loss of BubR1 acetylation causes defects
in spindle assembly checkpoint signaling
and promotes tumor formation . . . . . . 295
Masayuki Onishi and
Nolan Ko and
Ryuichi Nishihama and
John R. Pringle Distinct roles of Rho1, Cdc42, and Cyk3
in septum formation and abscission
during yeast cytokinesis . . . . . . . . 311
Helene Knævelsrud and
Kristiane Sòreng and
Camilla Raiborg and
Karin Håberg and
Fredrik Rasmuson and
Andreas Brech and
Knut Liestòl and
Tor Erik Rusten and
Harald Stenmark and
Thomas P. Neufeld and
Sven R. Carlsson and
Anne Simonsen Membrane remodeling by the PX--BAR
protein SNX18 promotes autophagosome
formation . . . . . . . . . . . . . . . 331
Yanmin Chen and
Zu-Hang Sheng Kinesin-1-syntaphilin coupling mediates
activity-dependent regulation of axonal
mitochondrial transport . . . . . . . . 351
Marco Antunes and
Telmo Pereira and
João V. Cordeiro and
Luis Almeida and
Antonio Jacinto Coordinated waves of actomyosin flow and
apical cell constriction immediately
after wounding . . . . . . . . . . . . . 365
Zu-Lin Chen and
Yao Yao and
Erin H. Norris and
Anna Kruyer and
Odella Jno-Charles and
Akbarshakh Akhmerov and
Sidney Strickland Ablation of astrocytic laminin impairs
vascular smooth muscle cell function and
leads to hemorrhagic stroke . . . . . . 381
Ben Short When two kinases are better than one . . ??
Ben Short Lis1 puts mRNAs in their place . . . . . 398
Ben Short Spastin coordinates the recycling
program . . . . . . . . . . . . . . . . ??
Ben Short The CCM complex puts a cap on integrin
activity . . . . . . . . . . . . . . . . 399
Caitlin Sedwick Bob Goldstein: Cell biology by way of
development . . . . . . . . . . . . . . 400
Xavier Deschênes-Simard and
Yusuke Mizukami and
Nabeel Bardeesy Macrophages in pancreatic cancer:
Starting things off on the wrong track 403
Vladan Lu\vci\'c and
Alexander Rigort and
Wolfgang Baumeister Cryo-electron tomography: The challenge
of doing structural biology in situ . . 407
Sophie Vidal-Eychenié and
Chantal Décaillet and
Jihane Basbous and
Angelos Constantinou DNA structure-specific priming of ATR
activation by DNA--PKcs . . . . . . . . 421
José-Eduardo Gomes and
Nicolas Tavernier and
Bénédicte Richaudeau and
Etienne Formstecher and
Thomas Boulin and
Paul E. Mains and
Julien Dumont and
Lionel Pintard Microtubule severing by the katanin
complex is activated by PPFR-1-dependent
MEI-1 dephosphorylation . . . . . . . . 431
Montserrat Bosch Grau and
Gloria Gonzalez Curto and
Cecilia Rocha and
Maria M. Magiera and
Patricia Marques Sousa and
Tiziana Giordano and
Nathalie Spassky and
Carsten Janke Tubulin glycylases and glutamylases have
distinct functions in stabilization and
motility of ependymal cilia . . . . . . 441
Konstantinos Lefkimmiatis and
Daniela Leronni and
Aldebaran M. Hofer The inner and outer compartments of
mitochondria are sites of distinct
cAMP/PKA signaling dynamics . . . . . . 453
Fiona E. Hood and
Samantha J. Williams and
Selena G. Burgess and
Mark W. Richards and
Daniel Roth and
Anne Straube and
Mark Pfuhl and
Richard Bayliss and
Stephen J. Royle Coordination of adjacent domains
mediates TACC3--ch--TOG--clathrin
assembly and mitotic spindle binding . . 463
Carly I. Dix and
Harish Chandra Soundararajan and
Nikola S. Dzhindzhev and
Farida Begum and
Beat Suter and
Hiroyuki Ohkura and
Elaine Stephens and
Simon L. Bullock Lissencephaly-1 promotes the recruitment
of dynein and dynactin to transported
mRNAs . . . . . . . . . . . . . . . . . 479
Meng-meng Fu and
Erika L. F. Holzbaur JIP1 regulates the directionality of APP
axonal transport by coordinating kinesin
and dynein motors . . . . . . . . . . . 495
David Shen and
Hua Yuan and
Alex Hutagalung and
Avani Verma and
Daniel Kümmel and
Xudong Wu and
Karin Reinisch and
James A. McNew and
Peter Novick The synaptobrevin homologue Snc2p
recruits the exocyst to secretory
vesicles by binding to Sec6p . . . . . . 509
Rachel Allison and
Jennifer H. Lumb and
Coralie Fassier and
James W. Connell and
Daniel Ten Martin and
Matthew N. J. Seaman and
Jamilé Hazan and
Evan Reid An ESCRT--spastin interaction promotes
fission of recycling tubules from the
endosome . . . . . . . . . . . . . . . . 527
Eva Faurobert and
Claire Rome and
Justyna Lisowska and
Sandra Manet-Dupé and
Gwénola Boulday and
Marilyne Malbouyres and
Martial Balland and
Anne-Pascale Bouin and
Michelle Kéramidas and
Daniel Bouvard and
Jean-Luc Coll and
Florence Ruggiero and
Elisabeth Tournier-Lasserve and
Corinne Albiges-Rizo CCM1--ICAP-$1$ complex controls $ \beta
$1 integrin-dependent endothelial
contractility and fibronectin remodeling 545
Geou-Yarh Liou and
Heike Döppler and
Brian Necela and
Murli Krishna and
Howard C. Crawford and
Massimo Raimondo and
Peter Storz Macrophage-secreted cytokines drive
pancreatic acinar-to-ductal metaplasia
through NF-$ \kappa $B and MMPs . . . . 563
Sébastien Britton and
Julia Coates and
Stephen P. Jackson A new method for high-resolution imaging
of Ku foci to decipher mechanisms of DNA
double-strand break repair . . . . . . . 579
Gul Civelekoglu-Scholey and
Bin He and
Muyao Shen and
Xiaohu Wan and
Emanuele Roscioli and
Brent Bowden and
Daniela Cimini Dynamic bonds and polar ejection force
distribution explain kinetochore
oscillations in PtK1 cells . . . . . . . 597
Ben Short Epiblast cells CLASP onto the basement
membrane . . . . . . . . . . . . . . . . ??
Ben Short Bruchpilot readies synaptic vesicles for
release . . . . . . . . . . . . . . . . ??
Ben Short Phosphorylation helps Atg18 get the
vacuole in shape . . . . . . . . . . . . ??
Ben Short Aurora B helps the central spindle
measure up . . . . . . . . . . . . . . . 601
Caitlin Sedwick Jody Rosenblatt: To extrude apically or
basally, that is the question . . . . . 602
Ricardo Nunes Bastos and
Sapan R. Gandhi and
Ryan D. Baron and
Ulrike Gruneberg and
Erich A. Nigg and
Francis A. Barr Aurora B suppresses microtubule dynamics
and limits central spindle size by
locally activating KIF4A . . . . . . . . 605
Ryota Uehara and
Yuki Tsukada and
Tomoko Kamasaki and
Ina Poser and
Kinya Yoda and
Daniel W. Gerlich and
Gohta Goshima Aurora B and Kif2A control microtubule
length for assembly of a functional
central spindle during anaphase . . . . 623
Yukiko Nakaya and
Erike W. Sukowati and
Guojun Sheng Epiblast integrity requires CLASP and
Dystroglycan-mediated microtubule
anchoring to the basal cortex . . . . . 637
Adi D. Dubash and
Jennifer L. Koetsier and
Evangeline V. Amargo and
Nicole A. Najor and
Robert M. Harmon and
Kathleen J. Green The GEF Bcr activates RhoA/MAL signaling
to promote keratinocyte differentiation
via desmoglein-1 . . . . . . . . . . . . 653
Tanja Matkovic and
Matthias Siebert and
Elena Knoche and
Harald Depner and
Sara Mertel and
David Owald and
Manuela Schmidt and
Ulrich Thomas and
Albert Sickmann and
Dirk Kamin and
Stefan W. Hell and
Jörg Bürger and
Christina Hollmann and
Thorsten Mielke and
Carolin Wichmann and
Stephan J. Sigrist The Bruchpilot cytomatrix determines the
size of the readily releasable pool of
synaptic vesicles . . . . . . . . . . . 667
Naoki Tamura and
Masahide Oku and
Moemi Ito and
Nobuo N. Noda and
Fuyuhiko Inagaki and
Yasuyoshi Sakai Atg18 phosphoregulation controls
organellar dynamics by modulating its
phosphoinositide-binding activity . . . 685
Nuno Saraiva and
David L. Prole and
Guia Carrara and
Benjamin F. Johnson and
Colin W. Taylor and
Maddy Parsons and
Geoffrey L. Smith hGAAP promotes cell adhesion and
migration via the stimulation of
store-operated Ca$^{2+}$ entry and
calpain 2 . . . . . . . . . . . . . . . 699
Beatriz G. Galvez and
Maurilio Sampaolesi and
Silvia Brunelli and
Diego Covarello and
Manuela Gavina and
Barbara Rossi and
Gabriela Constantin and
Yvan Torrente and
Giulio Cossu Complete repair of dystrophic skeletal
muscle by mesoangioblasts with enhanced
migration ability . . . . . . . . . . . 715
Grzegorz Nalepa and
Jill Barnholtz-Sloan and
Rikki Enzor and
Dilip Dey and
Ying He and
Jeff R. Gehlhausen and
Amalia S. Lehmann and
Su-Jung Park and
Yanzhu Yang and
Xianlin Yang and
Shi Chen and
Xiaowei Guan and
Yanwen Chen and
Jamie Renbarger and
Feng-Chun Yang and
Luis F. Parada and
Wade Clapp The tumor suppressor CDKN3 controls
mitosis . . . . . . . . . . . . . . . . 717
Mitch Leslie Injured neurons pump up the volume . . . ??
Mitch Leslie Drebrin shows self-restraint . . . . . . ??
Mitch Leslie Crawling cells feel the squeeze . . . . 721
Caitlin Sedwick Helder Maiato: Hot (+)TIPs on mitosis 722
Jonathan A. Cooper Mechanisms of cell migration in the
nervous system . . . . . . . . . . . . . 725
Dileep Varma and
Xiaohu Wan and
Dhanya Cheerambathur and
Reto Gassmann and
Aussie Suzuki and
Josh Lawrimore and
Arshad Desai and
E. D. Salmon Spindle assembly checkpoint proteins are
positioned close to core microtubule
attachment sites at kinetochores . . . . 735
Sarah Huntwork-Rodriguez and
Bei Wang and
Trent Watkins and
Arundhati Sengupta Ghosh and
Christine D. Pozniak and
Daisy Bustos and
Kim Newton and
Donald S. Kirkpatrick and
Joseph W. Lewcock JNK-mediated phosphorylation of DLK
suppresses its ubiquitination to promote
neuronal apoptosis . . . . . . . . . . . 747
Claudio Vernieri and
Elena Chiroli and
Valentina Francia and
Fridolin Gross and
Andrea Ciliberto Adaptation to the spindle checkpoint is
regulated by the interplay between
Cdc28/Clbs and PP2A$^{\rm Cdc55}$ . . . 765
Jason Yi and
Xufeng Wu and
Andrew H. Chung and
James K. Chen and
Tarun M. Kapoor and
John A. Hammer Centrosome repositioning in T cells is
biphasic and driven by microtubule
end-on capture-shrinkage . . . . . . . . 779
Daniel C. Worth and
Catherine N. Daly and
Sara Geraldo and
Fazal Oozeer and
Phillip R. Gordon-Weeks Drebrin contains a cryptic
F-actin--bundling activity regulated by
Cdk5 phosphorylation . . . . . . . . . . 793
Wei-Chien Hung and
Shih-Hsun Chen and
Colin D. Paul and
Kimberly M. Stroka and
Ying-Chun Lo and
Joy T. Yang and
Konstantinos Konstantopoulos Distinct signaling mechanisms regulate
migration in unconfined versus confined
spaces . . . . . . . . . . . . . . . . . 807
Nadine Bakkar and
Jingxin Wang and
Katherine J. Ladner and
Huating Wang and
Jason M. Dahlman and
Micheal Carathers and
Swarnali Acharyya and
Michael A. Rudnicki and
Andrew D. Hollenbach and
Denis C. Guttridge IKK\slash NF-$ \kappa $B regulates
skeletal myogenesis via a signaling
switch to inhibit differentiation and
promote mitochondrial biogenesis . . . . 825
Mitch Leslie Drs2 flips the phospholipid switch . . . ??
Mitch Leslie Rap1 helps endothelial cells stay close ??
Mitch Leslie Silicon nanocrystals shine . . . . . . . ??
Mitch Leslie Creating cellular inequality . . . . . . 829
Caitlin Sedwick Frances Brodsky: So you think you know
all about clathrin? . . . . . . . . . . 830
Christine Lawson and
David D. Schlaepfer pHocal adhesion kinase regulation is on
a FERM foundation . . . . . . . . . . . 833
Tommy L. Lewis and
Julien Courchet and
Franck Polleux Cellular and molecular mechanisms
underlying axon formation, growth, and
branching . . . . . . . . . . . . . . . 837
Chang-Hoon Choi and
Bradley A. Webb and
Michael S. Chimenti and
Matthew P. Jacobson and
Diane L. Barber pH sensing by FAK--His58 regulates focal
adhesion remodeling . . . . . . . . . . 849
Kazutaka Araki and
Shun-ichiro Iemura and
Yukiko Kamiya and
David Ron and
Koichi Kato and
Tohru Natsume and
Kazuhiro Nagata Ero1-$ \alpha $ and PDIs constitute a
hierarchical electron transfer network
of endoplasmic reticulum oxidoreductases 861
Peng Xu and
Ryan D. Baldridge and
Richard J. Chi and
Christopher G. Burd and
Todd R. Graham Phosphatidylserine flipping enhances
membrane curvature and negative charge
required for vesicular transport . . . . 875
Michaela T. Niessen and
Jeanie Scott and
Julia G. Zielinski and
Susanne Vorhagen and
Panagiota A. Sotiropoulou and
Cédric Blanpain and
Michael Leitges and
Carien M. Niessen aPKC$ \lambda $ controls epidermal
homeostasis and stem cell fate through
regulation of division orientation . . . 887
Koji Ando and
Shigetomo Fukuhara and
Takahiro Moriya and
Yutaro Obara and
Norimichi Nakahata and
Naoki Mochizuki Rap1 potentiates endothelial cell
junctions by spatially controlling
myosin II activity and actin
organization . . . . . . . . . . . . . . 901
Guillaume Jacquemet and
David M. Green and
Rebecca E. Bridgewater and
Alexander von Kriegsheim and
Martin J. Humphries and
Jim C. Norman and
Patrick T. Caswell RCP-driven $ \alpha $5$ \beta $1
recycling suppresses Rac and promotes
RhoA activity via the RacGAP1--IQGAP1
complex . . . . . . . . . . . . . . . . 917
Qingwei Zhu and
Yong Hwan Kim and
Douglas Wang and
S. Paul Oh and
Kunxin Luo SnoN facilitates ALK1-Smad1/5 signaling
during embryonic angiogenesis . . . . . 937
Daniel H. Madsen and
Daniel Leonard and
Andrius Masedunskas and
Amanda Moyer and
Henrik Jessen Jürgensen and
Diane E. Peters and
Panomwat Amornphimoltham and
Arul Selvaraj and
Susan S. Yamada and
David A. Brenner and
Sven Burgdorf and
Lars H. Engelholm and
Niels Behrendt and
Kenn Holmbeck and
Roberto Weigert and
Thomas H. Bugge M2-like macrophages are responsible for
collagen degradation through a mannose
receptor-mediated pathway . . . . . . . 951
Hirohito Nishimura and
Ken Ritchie and
Rinshi S. Kasai and
Miki Goto and
Nobuhiro Morone and
Hiroyuki Sugimura and
Koichiro Tanaka and
Ichiro Sase and
Akihiko Yoshimura and
Yoshitaro Nakano and
Takahiro K. Fujiwara and
Akihiro Kusumi Biocompatible fluorescent silicon
nanocrystals for single-molecule
tracking and fluorescence imaging . . . 967
Ben Short Determining the replication factory
settings . . . . . . . . . . . . . . . . ??
Ben Short KASH5 helps meiotic chromosomes LINC up ??
Ben Short RNA granules act as egg timers . . . . . ??
Ben Short PLP helps the mother centrosome stay mum 987
Caitlin Sedwick Michael Sixt: Love the way they move . . 988
Toshiaki Shigeoka and
Bo Lu and
Christine E. Holt RNA-based mechanisms underlying axon
guidance . . . . . . . . . . . . . . . . 991
Nazan Saner and
Jens Karschau and
Toyoaki Natsume and
Marek Gierli\'nski and
Renata Retkute and
Michelle Hawkins and
Conrad A. Nieduszynski and
J. Julian Blow and
Alessandro P. S. de Moura and
Tomoyuki U. Tanaka Stochastic association of neighboring
replicons creates replication factories
in budding yeast . . . . . . . . . . . . 1001
Dorothy A. Lerit and
Nasser M. Rusan PLP inhibits the activity of interphase
centrosomes to ensure their proper
segregation in stem cells . . . . . . . 1013
Henning F. Horn and
Dae In Kim and
Graham D. Wright and
Esther Sook Miin Wong and
Colin L. Stewart and
Brian Burke and
Kyle J. Roux A mammalian KASH domain protein coupling
meiotic chromosomes to the cytoskeleton 1023
Tomoya Kotani and
Kyota Yasuda and
Ryoma Ota and
Masakane Yamashita Cyclin B1 mRNA translation is temporally
controlled through formation and
disassembly of RNA granules . . . . . . 1041
Weiwei Luo and
Cheng-han Yu and
Zi Zhao Lieu and
Jun Allard and
Alex Mogilner and
Michael P. Sheetz and
Alexander D. Bershadsky Analysis of the local organization and
dynamics of cellular actin networks . . 1057
Diego E. Alvarez and
Hervé Agaisse The formin FHOD1 and the small GTPase
Rac1 promote vaccinia virus actin-based
motility . . . . . . . . . . . . . . . . 1075
Sarah E. Smith and
Boris Rubinstein and
Inês Mendes Pinto and
Brian D. Slaughter and
Jay R. Unruh and
Rong Li Independence of symmetry breaking on
Bem1-mediated autocatalytic activation
of Cdc42 . . . . . . . . . . . . . . . . 1091
Constance S. Petit and
Agnes Roczniak-Ferguson and
Shawn M. Ferguson Recruitment of folliculin to lysosomes
supports the amino acid-dependent
activation of Rag GTPases . . . . . . . 1107
Qiaoqiao Xu and
Shanshan Huang and
Mingke Song and
Chuan-En Wang and
Sen Yan and
Xudong Liu and
Marta A. Gaertig and
Shan Ping Yu and
He Li and
Shihua Li and
Xiao-Jiang Li Synaptic mutant huntingtin inhibits
synapsin-1 phosphorylation and causes
neurological symptoms . . . . . . . . . 1123
Ben Short Histone H1 gets Pin'd onto chromatin . . ??
Ben Short MAD2L2 helps mitotic cells take it slow ??
Ben Short Ubiquitin isolates bacterial invaders ??
Ben Short Formin' the cytokinetic ring . . . . . . 3
Caitlin Sedwick Yohanns Bella\"\iche: Mastering
multiscale morphology . . . . . . . . . 4
Yukiko M. Yamashita Nonrandom template segregation: a way to
break the symmetry of stem cells . . . . 7
Poh Hui Chia and
Pengpeng Li and
Kang Shen Cellular and molecular mechanisms
underlying presynapse formation . . . . 11
Joshua D. Ochocki and
M. Celeste Simon Nutrient-sensing pathways and metabolic
regulation in stem cells . . . . . . . . 23
Haifeng Wang and
Ingrid Brust-Mascher and
Gul Civelekoglu-Scholey and
Jonathan M. Scholey Patronin mediates a switch from
kinesin-$ 13$-dependent poleward flux to
anaphase B spindle elongation . . . . . 35
Daniel Lafkas and
Veronica Rodilla and
Mathilde Huyghe and
Larissa Mourao and
Hippokratis Kiaris and
Silvia Fre Notch3 marks clonogenic mammary luminal
progenitor cells in vivo . . . . . . . . 47
Nikhil Raghuram and
Hilmar Strickfaden and
Darin McDonald and
Kylie Williams and
He Fang and
Craig Mizzen and
Jeffrey J. Hayes and
John Th'ng and
Michael J. Hendzel Pin1 promotes histone H1
dephosphorylation and stabilizes its
binding to chromatin . . . . . . . . . . 57
Christian Elabd and
Wendy Cousin and
Robert Y. Chen and
Marc S. Chooljian and
Joey T. Pham and
Irina M. Conboy and
Michael J. Conboy DNA methyltransferase-$3$-dependent
nonrandom template segregation in
differentiating embryonic stem cells . . 73
Tamar Listovsky and
Julian E. Sale Sequestration of CDH1 by MAD2L2 prevents
premature APC/C activation prior to
anaphase onset . . . . . . . . . . . . . 87
Valerie C. Coffman and
Jennifer A. Sees and
David R. Kovar and
Jian-Qiu Wu The formins Cdc12 and For3 cooperate
during contractile ring assembly in
cytokinesis . . . . . . . . . . . . . . 101
Naonobu Fujita and
Eiji Morita and
Takashi Itoh and
Atsushi Tanaka and
Megumi Nakaoka and
Yuki Osada and
Tetsuo Umemoto and
Tatsuya Saitoh and
Hitoshi Nakatogawa and
Shouhei Kobayashi and
Tokuko Haraguchi and
Jun-Lin Guan and
Kazuhiro Iwai and
Fuminori Tokunaga and
Kazunobu Saito and
Koutaro Ishibashi and
Shizuo Akira and
Mitsunori Fukuda and
Takeshi Noda and
Tamotsu Yoshimori Recruitment of the autophagic machinery
to endosomes during infection is
mediated by ubiquitin . . . . . . . . . 115
David K. Breslow and
Elena F. Koslover and
Federica Seydel and
Andrew J. Spakowitz and
Maxence V. Nachury An in vitro assay for entry into cilia
reveals unique properties of the soluble
diffusion barrier . . . . . . . . . . . 129
Ka-wing Fong and
Yujing Li and
Wenqi Wang and
Wenbin Ma and
Kunpeng Li and
Robert Z. Qi and
Dan Liu and
Zhou Songyang and
Junjie Chen Whole-genome screening identifies
proteins localized to distinct nuclear
bodies . . . . . . . . . . . . . . . . . 149
Cherilyn M. Sirois and
Tengchuan Jin and
Allison L. Miller and
Damien Bertheloot and
Hirotaka Nakamura and
Gabor L. Horvath and
Abubakar Mian and
Jiansheng Jiang and
Jacob Schrum and
Lukas Bossaller and
Karin Pelka and
Natalio Garbi and
Yambasu Brewah and
Jane Tian and
Chew-Shun Chang and
Partha Chowdhury and
Gary Sims and
Roland Kolbeck and
Anthony Coyle and
Alison Humbles and
T. Sam Xiao and
Eicke Latz RAGE is a nucleic acid receptor that
promotes inflammatory responses to DNA ??
Helena Soares and
Ricardo Henriques and
Martin Sachse and
Leandro Ventimiglia and
Miguel A. Alonso and
Christophe Zimmer and
Maria-Isabel Thoulouze and
Andres Alcover Regulated vesicle fusion generates
signaling nanoterritories that control
T-cell activation at the immunological
synapse . . . . . . . . . . . . . . . . ??
Xuan Zhou and
Maria Carolina Florian and
Paritha Arumugam and
Xiaoyi Chen and
Jose A. Cancelas and
Richard Lang and
Punam Malik and
Hartmut Geiger and
Yi Zheng RhoA GTPase controls cytokinesis and
programmed necrosis of hematopoietic
progenitors . . . . . . . . . . . . . . ??
Dong Wang and
Damien O'Halloran and
Miriam B. Goodman GCY-8, PDE-2, and NCS-1 are critical
elements of the cGMP-dependent
thermotransduction cascade in the AFD
neurons responsible for \bionameC.
elegans thermotaxis . . . . . . . . . . ??
Mitch Leslie Putting Cyclin E in the trash . . . . . ??
Mitch Leslie Polysaccharide's central role in cell
division . . . . . . . . . . . . . . . . ??
Mitch Leslie Dynamin 2 cuts the cord for newborn
lysosome . . . . . . . . . . . . . . . . ??
Mitch Leslie Ensuring that yeast cells get their
inheritance . . . . . . . . . . . . . . 167
Caitlin Sedwick Daniel Colón--Ramos: Observing and making
connections . . . . . . . . . . . . . . 168
Dong Wang and
P. Robin Hiesinger The vesicular ATPase: a missing link
between acidification and exocytosis . . 171
Nathalia Vitureira and
Yukiko Goda The interplay between Hebbian and
homeostatic synaptic plasticity . . . . 175
Tadashi Makio and
Diego L. Lapetina and
Richard W. Wozniak Inheritance of yeast nuclear pore
complexes requires the Nsp1p subcomplex 187
Jennifer E. Dulle and
Rachel E. Bouttenot and
Lisa A. Underwood and
Heather L. True Soluble oligomers are sufficient for
transmission of a yeast prion but do not
confer phenotype . . . . . . . . . . . . 197
Sarah Oddoux and
Kristien J. Zaal and
Victoria Tate and
Aster Kenea and
Shuktika A. Nandkeolyar and
Ericka Reid and
Wenhua Liu and
Evelyn Ralston Microtubules that form the stationary
lattice of muscle fibers are dynamic and
nucleated at Golgi elements . . . . . . 205
Paolo Colombi and
Brant M. Webster and
Florian Fröhlich and
C. Patrick Lusk The transmission of nuclear pore
complexes to daughter cells requires a
cytoplasmic pool of Nsp1 . . . . . . . . 215
Albert Lu and
Suzanne R. Pfeffer Golgi-associated RhoBTB3 targets Cyclin
E for ubiquitylation and promotes cell
cycle progression . . . . . . . . . . . 233
Francisco Lázaro-Diéguez and
David Cohen and
Dawn Fernandez and
Louis Hodgson and
Sven C. D. van IJzendoorn and
Anne Müsch Par1b links lumen polarity with
LGN--NuMA positioning for distinct
epithelial cell division phenotypes . . 251
Javier Muñoz and
Juan Carlos G. Cortés and
Matthias Sipiczki and
Mariona Ramos and
José Angel Clemente-Ramos and
M. Belén Moreno and
Ivone M. Martins and
Pilar Pérez and
Juan Carlos Ribas Extracellular cell wall $ \beta $
(1,3)glucan is required to couple
septation to actomyosin ring contraction 265
Sandrine Poëa-Guyon and
Mohamed Raafet Ammar and
Marie Erard and
Muriel Amar and
Alexandre W. Moreau and
Philippe Fossier and
Vincent Gleize and
Nicolas Vitale and
Nicolas Morel The V--ATPase membrane domain is a
sensor of granular pH that controls the
exocytotic machinery . . . . . . . . . . 283
Yasuhiro Araki and
Wei-Chi Ku and
Manami Akioka and
Alexander I. May and
Yu Hayashi and
Fumio Arisaka and
Yasushi Ishihama and
Yoshinori Ohsumi Atg38 is required for autophagy-specific
phosphatidylinositol $3$-kinase complex
integrity . . . . . . . . . . . . . . . 299
Ryan J. Schulze and
Shaun G. Weller and
Barbara Schroeder and
Eugene W. Krueger and
Susan Chi and
Carol A. Casey and
Mark A. McNiven Lipid droplet breakdown requires Dynamin
2 for vesiculation of autolysosomal
tubules in hepatocytes . . . . . . . . . 315
Bhaskar Ponugoti and
Fanxing Xu and
Chenying Zhang and
Chen Tian and
Sandra Pacios and
Dana T. Graves FOXO1 promotes wound healing through the
up-regulation of TGF-$ \beta $1 and
prevention of oxidative stress . . . . . 327
Catherine E. Winbanks and
Justin L. Chen and
Hongwei Qian and
Yingying Liu and
Bianca C. Bernardo and
Claudia Beyer and
Kevin I. Watt and
Rachel E. Thomson and
Timothy Connor and
Bradley J. Turner and
Julie R. McMullen and
Lars Larsson and
Sean L. McGee and
Craig A. Harrison and
Paul Gregorevic The bone morphogenetic protein axis is a
positive regulator of skeletal muscle
mass . . . . . . . . . . . . . . . . . . 345
Benedetta Cerruti and
Alberto Puliafito and
Annette M. Shewan and
Wei Yu and
Alexander N. Combes and
Melissa H. Little and
Federica Chianale and
Luca Primo and
Guido Serini and
Keith E. Mostov and
Antonio Celani and
Andrea Gamba Polarity, cell division, and
out-of-equilibrium dynamics control the
growth of epithelial structures . . . . 359
Vincent Mirouse and
Lance L. Swick and
Nevzat Kazgan and
Daniel St Johnston and
Jay E. Brenman LKB1 and AMPK maintain epithelial cell
polarity under energetic stress . . . . 373
Ben Short Yeast centromeres coordinate their
movements . . . . . . . . . . . . . . . ??
Ben Short FRETting over kinesin activity . . . . . ??
Ben Short Switching on synaptic PP1 . . . . . . . ??
Ben Short Sortilins get a new delivery route . . . 377
Caitlin Sedwick Chris Bakal: Look and learn . . . . . . 378
Yael Eshed-Eisenbach and
Elior Peles Axonal spectrins: All-purpose fences . . 381
Martijn P. J. Dekkers and
Vassiliki Nikoletopoulou and
Yves-Alain Barde Death of developing neurons: New
insights and implications for
connectivity . . . . . . . . . . . . . . 385
Megan M. Corty and
Marc R. Freeman Architects in neural circuit design:
Glia control neuron numbers and
connectivity . . . . . . . . . . . . . . 395
Andrew D. Stephens and
Chloe E. Snider and
Julian Haase and
Rachel A. Haggerty and
Paula A. Vasquez and
M. Gregory Forest and
Kerry Bloom Individual pericentromeres display
coordinated motion and stretching in the
yeast spindle . . . . . . . . . . . . . 407
Kazuhiro Tateishi and
Yuji Yamazaki and
Tomoki Nishida and
Shin Watanabe and
Koshi Kunimoto and
Hiroaki Ishikawa and
Sachiko Tsukita Two appendages homologous between basal
bodies and centrioles are formed using
distinct Odf2 domains . . . . . . . . . 417
Michael D. Huber and
Paul W. Vesely and
Kaustuv Datta and
Larry Gerace Erlins restrict SREBP activation in the
ER and regulate cellular cholesterol
homeostasis . . . . . . . . . . . . . . 427
Chuansheng Zhang and
Keiichiro Susuki and
Daniel R. Zollinger and
Jeffrey L. Dupree and
Matthew N. Rasband Membrane domain organization of
myelinated axons requires $ \beta $II
spectrin . . . . . . . . . . . . . . . . 437
Cedric Espenel and
Bipul R. Acharya and
Geri Kreitzer A biosensor of local kinesin activity
reveals roles of PKC and EB1 in KIF17
activation . . . . . . . . . . . . . . . 445
Nima Mosammaparast and
Haeyoung Kim and
Benoit Laurent and
Yu Zhao and
Hui Jun Lim and
Mona C. Majid and
Sebastian Dango and
Yuying Luo and
Kristina Hempel and
Mathew E. Sowa and
Steven P. Gygi and
Hanno Steen and
J. Wade Harper and
Bruce Yankner and
Yang Shi The histone demethylase LSD1/KDM1A
promotes the DNA damage response . . . . 457
Andrew B. Lane and
Juan F. Giménez-Abián and
Duncan J. Clarke A novel chromatin tether domain controls
topoisomerase II$ \alpha $ dynamics and
mitotic chromosome formation . . . . . . 471
Nour El Amine and
Amel Kechad and
Silvana Jananji and
Gilles R. X. Hickson Opposing actions of septins and Sticky
on Anillin promote the transition from
contractile to midbody ring . . . . . . 487
Rebecca A. Green and
Jonathan R. Mayers and
Shaohe Wang and
Lindsay Lewellyn and
Arshad Desai and
Anjon Audhya and
Karen Oegema The midbody ring scaffolds the
abscission machinery in the absence of
midbody microtubules . . . . . . . . . . 505
Hailong Hou and
Lu Sun and
Benjamin A. Siddoway and
Ronald S. Petralia and
Hongtian Yang and
Hua Gu and
Angus C. Nairn and
Houhui Xia Synaptic NMDA receptor stimulation
activates PP1 by inhibiting its
phosphorylation by Cdk5 . . . . . . . . 521
Joseph S. Briguglio and
Santosh Kumar and
Aaron P. Turkewitz Lysosomal sorting receptors are
essential for secretory granule
biogenesis in \bionameTetrahymena . . . 537
Ben Short Microtubules support nuclear
nonproliferation arrangement . . . . . . ??
Ben Short AKT shuts down the TOR network . . . . . ??
Ben Short A call for oxygen in the ER . . . . . . ??
Ben Short Lamellipodin branches out . . . . . . . 553
Caitlin Sedwick Marilyn Farquhar: From the beginning . . 554
Ira Mellman and
Scott D. Emr A Nobel Prize for membrane traffic:
Vesicles find their journey's end . . . 559
Charles Betz and
Michael N. Hall Where is mTOR and what is it doing
there? . . . . . . . . . . . . . . . . . 563
Zhao Zhang and
Jing Feng and
Chenyu Pan and
Xiangdong Lv and
Wenqing Wu and
Zhaocai Zhou and
Feng Liu and
Lei Zhang and
Yun Zhao Atrophin--Rpd3 complex represses
Hedgehog signaling by acting as a
corepressor of Ci$^R$ . . . . . . . . . 575
Damien Laporte and
Fabien Courtout and
Bénédicte Salin and
Johanna Ceschin and
Isabelle Sagot An array of nuclear microtubules
reorganizes the budding yeast nucleus
during quiescence . . . . . . . . . . . 585
Lenka Hálová and
Wei Du and
Sara Kirkham and
Duncan L. Smith and
Janni Petersen Phosphorylation of the TOR ATP binding
domain by AGC kinase constitutes a novel
mode of TOR inhibition . . . . . . . . . 595
Tomoki Yano and
Takeshi Matsui and
Atsushi Tamura and
Masami Uji and
Sachiko Tsukita The association of microtubules with
tight junctions is promoted by cingulin
phosphorylation by AMPK . . . . . . . . 605
Marianne Koritzinsky and
Fiana Levitin and
Twan van den Beucken and
Ryan A. Rumantir and
Nicholas J. Harding and
Kenneth C. Chu and
Paul C. Boutros and
Ineke Braakman and
Bradly G. Wouters Two phases of disulfide bond formation
have differing requirements for oxygen 615
Mehmet Sen and
Koichi Yuki and
Timothy A. Springer An internal ligand-bound, metastable
state of a leukocyte integrin, $
\alpha_X $ $ \beta_2 $ . . . . . . . . . 629
Ashraf Yusuf Rangrez and
Alexander Bernt and
Reza Poyanmehr and
Violetta Harazin and
Inka Boomgaarden and
Christian Kuhn and
Astrid Rohrbeck and
Derk Frank and
Norbert Frey Dysbindin is a potent inducer of
RhoA--SRF-mediated cardiomyocyte
hypertrophy . . . . . . . . . . . . . . 643
Douglas S. Campbell and
Hitoshi Okamoto Local caspase activation interacts with
Slit--Robo signaling to restrict axonal
arborization . . . . . . . . . . . . . . 657
Ah-Lai Law and
Anne Vehlow and
Maria Kotini and
Lauren Dodgson and
Daniel Soong and
Eric Theveneau and
Cristian Bodo and
Eleanor Taylor and
Christel Navarro and
Upamali Perera and
Magdalene Michael and
Graham A. Dunn and
Daimark Bennett and
Roberto Mayor and
Matthias Krause Lamellipodin and the Scar/WAVE complex
cooperate to promote cell migration in
vivo . . . . . . . . . . . . . . . . . . 673
Kai Safferling and
Thomas Sütterlin and
Kathi Westphal and
Claudia Ernst and
Kai Breuhahn and
Merlin James and
Dirk Jäger and
Niels Halama and
Niels Grabe Wound healing revised: a novel
reepithelialization mechanism revealed
by in vitro and in silico models . . . . 691
Mitch Leslie Shelterin protein keeps telomeres on
edge . . . . . . . . . . . . . . . . . . ??
Mitch Leslie Actin-capping protein lets epithelial
cells take the pressure . . . . . . . . ??
Mitch Leslie Sip1 liberates neural crest cells . . . ??
Mitch Leslie Silent RNAs express themselves . . . . . 713
Caitlin Sedwick Trina Schroer: What's cooking on
dynactin . . . . . . . . . . . . . . . . 714
Camilla Godlee and
Marko Kaksonen From uncertain beginnings: Initiation
mechanisms of clathrin-mediated
endocytosis . . . . . . . . . . . . . . 717
Helder C. Ferreira and
Benjamin D. Towbin and
Thibaud Jegou and
Susan M. Gasser The shelterin protein POT-1 anchors
\bionameCaenorhabditis elegans telomeres
through SUN-1 at the nuclear periphery 727
Kyota Yasuda and
Huaye Zhang and
David Loiselle and
Timothy Haystead and
Ian G. Macara and
Stavroula Mili The RNA-binding protein Fus directs
translation of localized mRNAs in
APC--RNP granules . . . . . . . . . . . 737
Joo-Hee Sir and
Monika Pütz and
Owen Daly and
Ciaran G. Morrison and
Mark Dunning and
John V. Kilmartin and
Fanni Gergely Loss of centrioles causes chromosomal
instability in vertebrate somatic cells 747
Susana Romao and
Nathalie Gasser and
Andrea C. Becker and
Bruno Guhl and
Milica Bajagic and
Danusia Vanoaica and
Urs Ziegler and
Joachim Roesler and
Jörn Dengjel and
Janine Reichenbach and
Christian Münz Autophagy proteins stabilize
pathogen-containing phagosomes for
prolonged MHC II antigen processing . . 757
Qian Bian and
Nimish Khanna and
Jurgis Alvikas and
Andrew S. Belmont $ \beta $-Globin cis-elements determine
differential nuclear targeting through
epigenetic modifications . . . . . . . . 767
Anna Franz and
Hélio Roque and
Saroj Saurya and
Jeroen Dobbelaere and
Jordan W. Raff CP110 exhibits novel regulatory
activities during centriole assembly in
\bionameDrosophila . . . . . . . . . . . 785
Songyu Wang and
Fabian B. Romano and
Christine M. Field and
Tim J. Mitchison and
Tom A. Rapoport Multiple mechanisms determine ER network
morphology during the cell cycle in
\bionameXenopus egg extracts . . . . . . 801
Vivian W. Tang and
William M. Brieher FSGS3\slash CD2AP is a barbed-end
capping protein that stabilizes actin
and strengthens adherens junctions . . . 815
Crystal D. Rogers and
Ankur Saxena and
Marianne E. Bronner Sip1 mediates an
E--cadherin--to--N--cadherin switch
during cranial neural crest EMT . . . . 835
Maike Kittelmann and
Jan Hegermann and
Alexandr Goncharov and
Hidenori Taru and
Mark H. Ellisman and
Janet E. Richmond and
Yishi Jin and
Stefan Eimer Liprin-$ \alpha $ \slash SYD-2
determines the size of dense projections
in presynaptic active zones in
\bionameC. elegans . . . . . . . . . . . 849
Ben Short Senescent cells have a case of the SADS ??
Ben Short T cells JAK up integrin activity . . . . ??
Ben Short p120 CLASPs microtubules to junctions ??
Ben Short Arp2\slash $3$-deficient cells share
their problems . . . . . . . . . . . . . 867
Caitlin Sedwick Arnaud Echard: Adieu, ma soeur . . . . . 868
Joel A. Swanson The noodle defense . . . . . . . . . . . 871
Clifford P. Brangwynne Phase transitions and size scaling of
membrane-less organelles . . . . . . . . 875
Nina Schweizer and
Cristina Ferrás and
David M. Kern and
Elsa Logarinho and
Iain M. Cheeseman and
Helder Maiato Spindle assembly checkpoint robustness
requires Tpr-mediated regulation of
Mad1/Mad2 proteostasis . . . . . . . . . 883
Xiaobo Bai and
Jonathan R. Bowen and
Tara K. Knox and
Kaifeng Zhou and
Manuela Pendziwiat and
Gregor Kuhlenbäumer and
Charles V. Sindelar and
Elias T. Spiliotis Novel septin 9 repeat motifs altered in
neuralgic amyotrophy bind and bundle
microtubules . . . . . . . . . . . . . . 895
Congying Wu and
Elizabeth M. Haynes and
Sreeja B. Asokan and
Jeremy M. Simon and
Norman E. Sharpless and
Albert S. Baldwin and
Ian J. Davis and
Gary L. Johnson and
James E. Bear Loss of Arp2/3 induces an NF-$ \kappa
$B-dependent, nonautonomous effect on
chemotactic signaling . . . . . . . . . 907
Elena A. Minina and
Lada H. Filonova and
Kazutake Fukada and
Eugene I. Savenkov and
Vladimir Gogvadze and
David Clapham and
Victoria Sanchez-Vera and
Maria F. Suarez and
Boris Zhivotovsky and
Geoffrey Daniel and
Andrei Smertenko and
Peter V. Bozhkov Autophagy and metacaspase determine the
mode of cell death in plants . . . . . . 917
Eric C. Swanson and
Benjamin Manning and
Hong Zhang and
Jeanne B. Lawrence Higher-order unfolding of satellite
heterochromatin is a consistent and
early event in cell senescence . . . . . 929
Mathijs Vleugel and
Eelco Tromer and
Manja Omerzu and
Vincent Groenewold and
Wilco Nijenhuis and
Berend Snel and
Geert J. P. L. Kops Arrayed BUB recruitment modules in the
kinetochore scaffold KNL1 promote
accurate chromosome segregation . . . . 943
Gina V. Caldas and
Keith F. DeLuca and
Jennifer G. DeLuca KNL1 facilitates phosphorylation of
outer kinetochore proteins by promoting
Aurora B kinase activity . . . . . . . . 957
Roland G. Heym and
Dennis Zimmermann and
Franziska T. Edelmann and
Lars Israel and
Zeynep Ökten and
David R. Kovar and
Dierk Niessing In vitro reconstitution of an
mRNA-transport complex reveals
mechanisms of assembly and motor
activation . . . . . . . . . . . . . . . 971
Adam Kassan and
Albert Herms and
Andrea Fernández-Vidal and
Marta Bosch and
Nicole L. Schieber and
Babu J. N. Reddy and
Alba Fajardo and
Mariona Gelabert-Baldrich and
Francesc Tebar and
Carlos Enrich and
Steven P. Gross and
Robert G. Parton and
Albert Pol Acyl-CoA synthetase 3 promotes lipid
droplet biogenesis in ER microdomains 985
Alessio Montresor and
Matteo Bolomini-Vittori and
Lara Toffali and
Barbara Rossi and
Gabriela Constantin and
Carlo Laudanna JAK tyrosine kinases promote
hierarchical activation of Rho and Rap
modules of integrin activation . . . . . 1003
Michael J. Ophir and
Beiyun C. Liu and
Stephen C. Bunnell The N terminus of SKAP55 enables T cell
adhesion to TCR and integrin ligands via
distinct mechanisms . . . . . . . . . . 1021
Marta N. Shahbazi and
Diego Megias and
Carolina Epifano and
Anna Akhmanova and
Gregg G. Gundersen and
Elaine Fuchs and
Mirna Perez-Moreno CLASP2 interacts with p120-catenin and
governs microtubule dynamics at adherens
junctions . . . . . . . . . . . . . . . 1043
Pedro Monteiro and
Carine Rossé and
Antonio Castro-Castro and
Marie Irondelle and
Emilie Lagoutte and
Perrine Paul-Gilloteaux and
Claire Desnos and
Etienne Formstecher and
François Darchen and
David Perrais and
Alexis Gautreau and
Maud Hertzog and
Philippe Chavrier Endosomal WASH and exocyst complexes
control exocytosis of MT1-MMP at
invadopodia . . . . . . . . . . . . . . 1063
Akriti Prashar and
Sonam Bhatia and
Darren Gigliozzi and
Tonya Martin and
Carla Duncan and
Cyril Guyard and
Mauricio R. Terebiznik Filamentous morphology of bacteria
delays the timing of phagosome
morphogenesis in macrophages . . . . . . 1081
Mitch Leslie Adducin-1 moonlights at the mitotic
spindle . . . . . . . . . . . . . . . . ??
Mitch Leslie Histone shortages hold back replication
forks . . . . . . . . . . . . . . . . . ??
Mitch Leslie Thyroid hormones speed cellular aging ??
Mitch Leslie Sending sisters their separate ways . . 3
Caitlin Sedwick Michael Kozlov: a twist in membrane
physics . . . . . . . . . . . . . . . . 4
Juan S. Bonifacino Adaptor proteins involved in polarized
sorting . . . . . . . . . . . . . . . . 7
Po-Chao Chan and
Rosaline Y. C. Hsu and
Chih-Wei Liu and
Chien-Chen Lai and
Hong-Chen Chen Adducin-1 is essential for mitotic
spindle assembly through its interaction
with myosin--X . . . . . . . . . . . . . 19
Jakob Mejlvang and
Yunpeng Feng and
Constance Alabert and
Kai J. Neelsen and
Zuzana Jasencakova and
Xiaobei Zhao and
Michael Lees and
Albin Sandelin and
Philippe Pasero and
Massimo Lopes and
Anja Groth New histone supply regulates replication
fork speed and PCNA unloading . . . . . 29
Susanne M. Germann and
Vera Schramke and
Rune Troelsgaard Pedersen and
Irene Gallina and
Nadine Eckert-Boulet and
Vibe H. Oestergaard and
Michael Lisby TopBP1\slash Dpb11 binds DNA anaphase
bridges to prevent genome instability 45
He Zhang and
Michael J. Zeitz and
Hong Wang and
Beibei Niu and
Shengfang Ge and
Wei Li and
Jiuwei Cui and
Guanjun Wang and
Guanxiang Qian and
Michael J. Higgins and
Xianqun Fan and
Andrew R. Hoffman and
Ji-Fan Hu Long noncoding RNA-mediated
intrachromosomal interactions promote
imprinting at the Kcnq1 locus . . . . . 61
Victoria Bulat and
Melanie Rast and
Jan Pielage Presynaptic CK2 promotes synapse
organization and stability by targeting
Ankyrin2 . . . . . . . . . . . . . . . . 77
Katie L. Vermillion and
Kevin A. Lidberg and
Laura S. Gammill Cytoplasmic protein methylation is
essential for neural crest migration . . 95
Ceniz Zihni and
Peter M. G. Munro and
Ahmed Elbediwy and
Nicholas H. Keep and
Stephen J. Terry and
John Harris and
Maria S. Balda and
Karl Matter Dbl3 drives Cdc42 signaling at the
apical margin to regulate junction
position and apical differentiation . . 111
Alberto Zambrano and
Verónica García-Carpizo and
María Esther Gallardo and
Raquel Villamuera and
Maria Ana Gómez-Ferrería and
Angel Pascual and
Nicolas Buisine and
Laurent M. Sachs and
Rafael Garesse and
Ana Aranda The thyroid hormone receptor $ \beta $
induces DNA damage and premature
senescence . . . . . . . . . . . . . . . 129
Mitch Leslie Double-checking DNA synthesis . . . . . ??
Mitch Leslie NEMO surfaces in NF-$ \kappa
$B-activating clusters . . . . . . . . . ??
Mitch Leslie The sources of cell stickiness . . . . . ??
Mitch Leslie Clearing the way for cancer cells . . . 149
Caitlin Sedwick Jonathon Howard: Motor proteins go
walkabout . . . . . . . . . . . . . . . 150
Uri Weissbein and
Nissim Benvenisty and
Uri Ben-David Genome maintenance in pluripotent stem
cells . . . . . . . . . . . . . . . . . 153
Maria M. Magiera and
Elisabeth Gueydon and
Etienne Schwob DNA replication and spindle checkpoints
cooperate during S phase to delay
mitosis and preserve genome integrity 165
Boubou Diagouraga and
Alexei Grichine and
Arnold Fertin and
Jin Wang and
Saadi Khochbin and
Karin Sadoul Motor-driven marginal band coiling
promotes cell shape change during
platelet activation . . . . . . . . . . 177
Sebastian Kötter and
Andreas Unger and
Nazha Hamdani and
Patrick Lang and
Matthias Vorgerd and
Luitgard Nagel-Steger and
Wolfgang A. Linke Human myocytes are protected from titin
aggregation-induced stiffening by small
heat shock proteins . . . . . . . . . . 187
Fenglan Dong and
Kyosuke Shinohara and
Yanick Botilde and
Ryo Nabeshima and
Yasuko Asai and
Akemi Fukumoto and
Toshiaki Hasegawa and
Moe Matsuo and
Hiroyuki Takeda and
Hidetaka Shiratori and
Tetsuya Nakamura and
Hiroshi Hamada Pih1d3 is required for cytoplasmic
preassembly of axonemal dynein in mouse
sperm . . . . . . . . . . . . . . . . . 203
Tetsuo Kobayashi and
Sehyun Kim and
Yu-Chun Lin and
Takanari Inoue and
Brian David Dynlacht The CP110-interacting proteins Talpid3
and Cep290 play overlapping and distinct
roles in cilia assembly . . . . . . . . 215
Nadine Tarantino and
Jean-Yves Tinevez and
Elizabeth Faris Crowell and
Bertrand Boisson and
Ricardo Henriques and
Musa Mhlanga and
Fabrice Agou and
Alain Israël and
Emmanuel Laplantine TNF and IL-1 exhibit distinct ubiquitin
requirements for inducing NEMO--IKK
supramolecular structures . . . . . . . 231
Christine Jean and
Xiao Lei Chen and
Ju-Ock Nam and
Isabelle Tancioni and
Sean Uryu and
Christine Lawson and
Kristy K. Ward and
Colin T. Walsh and
Nichol L. G. Miller and
Majid Ghassemian and
Patric Turowski and
Elisabetta Dejana and
Sara Weis and
David A. Cheresh and
David D. Schlaepfer Inhibition of endothelial FAK activity
prevents tumor metastasis by enhancing
barrier function . . . . . . . . . . . . 247
Christopher P. Toret and
Michael V. D'Ambrosio and
Ronald D. Vale and
Michael A. Simon and
W. James Nelson A genome-wide screen identifies
conserved protein hubs required for
cadherin-mediated cell--cell adhesion 265
Ben Short CAL1 builds centromeres on the fly . . . ??
Ben Short A mutual interest in prostaglandin
signaling . . . . . . . . . . . . . . . ??
Ben Short Prion infections come with strings
attached . . . . . . . . . . . . . . . . ??
Ben Short KIF13B erects an endocytic scaffold . . 283
Caitlin Sedwick Ottoline Leyser: The beauty of plant
genetics . . . . . . . . . . . . . . . . 284
Isabel M. Palacios Hop-on hop-off: Polysomes take a tour of
the cell on endosomes . . . . . . . . . 287
Laura C. Kelley and
Lauren L. Lohmer and
Elliott J. Hagedorn and
David R. Sherwood Traversing the basement membrane in
vivo: a diversity of strategies . . . . 291
Valentina Debattisti and
Diana Pendin and
Elena Ziviani and
Andrea Daga and
Luca Scorrano Reduction of endoplasmic reticulum
stress attenuates the defects caused by
\bionameDrosophila mitofusin depletion 303
Chin-Chi Chen and
Mekonnen Lemma Dechassa and
Emily Bettini and
Mary B. Ledoux and
Christian Belisario and
Patrick Heun and
Karolin Luger and
Barbara G. Mellone CAL1 is the \bionameDrosophila CENP--A
assembly factor . . . . . . . . . . . . 313
Takatoshi Iijima and
Yoko Iijima and
Harald Witte and
Peter Scheiffele Neuronal cell type--specific alternative
splicing is regulated by the KH domain
protein SLM1 . . . . . . . . . . . . . . 331
Yujiro Higuchi and
Peter Ashwin and
Yvonne Roger and
Gero Steinberg Early endosome motility spatially
organizes polysome distribution . . . . 343
Jessica Zapata and
Noah Dephoure and
Tracy MacDonough and
Yaxin Yu and
Emily J. Parnell and
Meghan Mooring and
Steven P. Gygi and
David J. Stillman and
Douglas R. Kellogg PP2A$^{\rm Rts1}$ is a master regulator
of pathways that control cell size . . . 359
Chantal Binda and
Samuel Génier and
Andréane Cartier and
Jean-François Larrivée and
Jana Stankova and
Jason C. Young and
Jean-Luc Parent A G protein--coupled receptor and the
intracellular synthase of its agonist
functionally cooperate . . . . . . . . . 377
Yoshimitsu Kanai and
Daliang Wang and
Nobutaka Hirokawa KIF13B enhances the endocytosis of LRP1
by recruiting LRP1 to caveolae . . . . . 395
Andreas Schaupp and
Ola Sabet and
Irina Dudanova and
Marion Ponserre and
Philippe Bastiaens and
Rüdiger Klein The composition of EphB2 clusters
determines the strength in the cellular
repulsion response . . . . . . . . . . . 409
Alexander Rouvinski and
Sharon Karniely and
Maria Kounin and
Sanaa Moussa and
Miri D. Goldberg and
Gabriela Warburg and
Roman Lyakhovetsky and
Dulce Papy-Garcia and
Janine Kutzsche and
Carsten Korth and
George A. Carlson and
Susan F. Godsave and
Peter J. Peters and
Katarina Luhr and
Krister Kristensson and
Albert Taraboulos Live imaging of prions reveals nascent
PrP$^{\rm Sc}$ in cell-surface,
raft-associated amyloid strings and webs 423
Denis Tsygankov and
Colleen G. Bilancia and
Eric A. Vitriol and
Klaus M. Hahn and
Mark Peifer and
Timothy C. Elston CellGeo: a computational platform for
the analysis of shape changes in cells
with complex geometries . . . . . . . . 443
Mitch Leslie Kicking MiD51 out of the enzyme club . . ??
Mitch Leslie Polarity proteins duel in
\bionameDrosophila . . . . . . . . . . . ??
Mitch Leslie Ndc1 catches the shuttle . . . . . . . . ??
Mitch Leslie Career guidance for stem cells . . . . . 463
Caitlin Sedwick Amy Gladfelter: Fungi with a streak of
individuality . . . . . . . . . . . . . 464
Jens Lykke-Andersen and
Eric J. Bennett Protecting the proteome: Eukaryotic
cotranslational quality control pathways 467
Viviane Richter and
Catherine S. Palmer and
Laura D. Osellame and
Abeer P. Singh and
Kirstin Elgass and
David A. Stroud and
Hiromi Sesaki and
Marc Kvansakul and
Michael T. Ryan Structural and functional analysis of
MiD51, a dynamin receptor required for
mitochondrial fission . . . . . . . . . 477
Clémence L. Gamblin and
Émilie J.-L. Hardy and
François J.-M. Chartier and
Nicolas Bisson and
Patrick Laprise A bidirectional antagonism between aPKC
and Yurt regulates epithelial cell
polarity . . . . . . . . . . . . . . . . 487
Douwe M. Veltman and
Michael G. Lemieux and
David A. Knecht and
Robert H. Insall PIP$_3$-dependent macropinocytosis is
incompatible with chemotaxis . . . . . . 497
Vincent Gaggioli and
Eva Zeiser and
David Rivers and
Charles R. Bradshaw and
Julie Ahringer and
Philip Zegerman CDK phosphorylation of SLD-2 is required
for replication initiation and germline
development in \bionameC. elegans . . . 507
Jingjing Chen and
Christine J. Smoyer and
Brian D. Slaughter and
Jay R. Unruh and
Sue L. Jaspersen The SUN protein Mps3 controls Ndc1
distribution and function on the nuclear
membrane . . . . . . . . . . . . . . . . 523
Taras Y. Nazarko and
Katharine Ozeki and
Andreas Till and
Geetha Ramakrishnan and
Pouya Lotfi and
Mingda Yan and
Suresh Subramani Peroxisomal Atg37 binds Atg30 or
palmitoyl--CoA to regulate phagophore
formation during pexophagy . . . . . . . 541
Alex J. Smith and
Byung-Ju Jin and
Julien Ratelade and
Alan S. Verkman Aggregation state determines the
localization and function of M1- and
M23--aquaporin-4 in astrocytes . . . . . 559
Sérgio de Matos Simões and
Avantika Mainieri and
Jennifer A. Zallen Rho GTPase and Shroom direct planar
polarized actomyosin contractility
during convergent extension . . . . . . 575
Gwenvael Le Dréau and
Murielle Saade and
Irene Gutiérrez-Vallejo and
Elisa Martí The strength of SMAD1/5 activity
determines the mode of stem cell
division in the developing spinal cord 591
Sho Morioka and
Peter Broglie and
Emily Omori and
Yuka Ikeda and
Giichi Takaesu and
Kunihiro Matsumoto and
Jun Ninomiya-Tsuji TAK1 kinase switches cell fate from
apoptosis to necrosis following TNF
stimulation . . . . . . . . . . . . . . 607
Ben Short BUB-1 makes kinetochores MAD . . . . . . ??
Ben Short Lamin-A provides stiff resistance to
cell migration . . . . . . . . . . . . . ??
Ben Short A surprising Twist to cell dissemination ??
Ben Short Mdm2 pulls the plug on glycolysis . . . 627
Caitlin Sedwick Feroz Papa: Saving cells from themselves 628
Takashi Ishikawa Protein tagging reveals new insights
into signaling in flagella . . . . . . . 631
Albert Pol and
Steven P. Gross and
Robert G. Parton Biogenesis of the multifunctional lipid
droplet: Lipids, proteins, and sites . . 635
Mark W. Moyle and
Taekyung Kim and
Neil Hattersley and
Julien Espeut and
Dhanya K. Cheerambathur and
Karen Oegema and
Arshad Desai A Bub1--Mad1 interaction targets the
Mad1--Mad2 complex to unattached
kinetochores to initiate the spindle
checkpoint . . . . . . . . . . . . . . . 647
K\`evin Knoops and
Selvambigai Manivannan and
Ma\lgorzata N. Cepi\'nska and
Arjen M. Krikken and
Anita M. Kram and
Marten Veenhuis and
Ida J. van der Klei Preperoxisomal vesicles can form in the
absence of Pex3 . . . . . . . . . . . . 659
Takamasa Harada and
Joe Swift and
Jerome Irianto and
Jae-Won Shin and
Kyle R. Spinler and
Avathamsa Athirasala and
Rocky Diegmiller and
P. C. Dave P. Dingal and
Irena L. Ivanovska and
Dennis E. Discher Nuclear lamin stiffness is a barrier to
$3$D migration, but softness can limit
survival . . . . . . . . . . . . . . . . 669
Tsuyoshi Morita and
Ken'ichiro Hayashi Arp5 is a key regulator of myocardin in
smooth muscle cells . . . . . . . . . . 683
Debora Keller and
Meritxell Orpinell and
Nicolas Olivier and
Malte Wachsmuth and
Robert Mahen and
Romain Wyss and
Virginie Hachet and
Jan Ellenberg and
Suliana Manley and
Pierre Gönczy Mechanisms of HsSAS-6 assembly promoting
centriole formation in human cells . . . 697
Pietri Puustinen and
Anna Rytter and
Monika Mortensen and
Pekka Kohonen and
José M. Moreira and
Marja Jäättelä CIP2A oncoprotein controls cell growth
and autophagy through mTORC1 activation 713
Takumi Mikawa and
Takeshi Maruyama and
Koji Okamoto and
Hitoshi Nakagama and
Matilde E. Lleonart and
Takeshi Tsusaka and
Kousuke Hori and
Itsuo Murakami and
Taisuke Izumi and
Akifumi Takaori-Kondo and
Masayuki Yokode and
Gordon Peters and
David Beach and
Hiroshi Kondoh Senescence-inducing stress promotes
proteolysis of phosphoglycerate mutase
via ubiquitin ligase Mdm2 . . . . . . . 729
Shenhav Cohen and
Donghoon Lee and
Bo Zhai and
Steven P. Gygi and
Alfred L. Goldberg Trim32 reduces PI3K--Akt--FoxO signaling
in muscle atrophy by promoting
plakoglobin--PI3K dissociation . . . . . 747
Tony Cijsouw and
Jens P. Weber and
Jurjen H. Broeke and
Jantine A. C. Broek and
Desiree Schut and
Tim Kroon and
Ingrid Saarloos and
Matthijs Verhage and
Ruud F. Toonen Munc18-1 redistributes in nerve
terminals in an activity- and
PKC-dependent manner . . . . . . . . . . 759
Nicholas Ariotti and
Manuel A. Fernández-Rojo and
Yong Zhou and
Michelle M. Hill and
Travis L. Rodkey and
Kerry L. Inder and
Lukas B. Tanner and
Markus R. Wenk and
John F. Hancock and
Robert G. Parton Caveolae regulate the nanoscale
organization of the plasma membrane to
remotely control Ras signaling . . . . . 777
Richard J. Chi and
Jingxuan Liu and
Matthew West and
Jing Wang and
Greg Odorizzi and
Christopher G. Burd Fission of SNX--BAR--coated endosomal
retrograde transport carriers is
promoted by the dynamin-related protein
Vps1 . . . . . . . . . . . . . . . . . . 793
Toshiyuki Oda and
Haruaki Yanagisawa and
Toshiki Yagi and
Masahide Kikkawa Mechanosignaling between central
apparatus and radial spokes controls
axonemal dynein activity . . . . . . . . 807
Emily Steed and
Ahmed Elbediwy and
Barbara Vacca and
Sébastien Dupasquier and
Sandra A. Hemkemeyer and
Tesha Suddason and
Ana C. Costa and
Jean-Bernard Beaudry and
Ceniz Zihni and
Ewen Gallagher and
Christophe E. Pierreux and
Maria S. Balda and
Karl Matter MarvelD3 couples tight junctions to the
MEKK1--JNK pathway to regulate cell
behavior and survival . . . . . . . . . 821
Eliah R. Shamir and
Elisa Pappalardo and
Danielle M. Jorgens and
Kester Coutinho and
Wen-Ting Tsai and
Khaled Aziz and
Manfred Auer and
Phuoc T. Tran and
Joel S. Bader and
Andrew J. Ewald Twist1-induced dissemination preserves
epithelial identity and requires
E-cadherin . . . . . . . . . . . . . . . 839
Ben Short Circumventing the Greatwall . . . . . . ??
Ben Short OPA1's shortcut to mitochondrial fission ??
Ben Short Tracking traction in amoeboid cells . . ??
Ben Short Motor proteins Hook on to early
endosomes . . . . . . . . . . . . . . . 859
Caitlin Sedwick Yves Barral: Lessons from yeast on
growth, renewal, and old age . . . . . . 860
Robert Walters and
Roy Parker Is there quality control of localized
mRNAs? . . . . . . . . . . . . . . . . . 863
Annamaria Ruggiano and
Ombretta Foresti and
Pedro Carvalho ER-associated degradation: Protein
quality control and beyond . . . . . . . 869
Eiichi Okumura and
Atsushi Morita and
Mizuho Wakai and
Satoru Mochida and
Masatoshi Hara and
Takeo Kishimoto Cyclin B--Cdk1 inhibits protein
phosphatase PP2A--B55 via a Greatwall
kinase--independent mechanism . . . . . 881
Ibtissem Nabti and
Petros Marangos and
Jenny Bormann and
Nobuaki R. Kudo and
John Carroll Dual-mode regulation of the APC/C by
CDK1 and MAPK controls meiosis I
progression and fidelity . . . . . . . . 891
Edward R. Ballister and
Michelle Riegman and
Michael A. Lampson Recruitment of Mad1 to metaphase
kinetochores is sufficient to reactivate
the mitotic checkpoint . . . . . . . . . 901
Batool Ossareh-Nazari and
Carlos A. Niño and
Mario H. Bengtson and
Joong-Won Lee and
Claudio A. P. Joazeiro and
Catherine Dargemont Ubiquitylation by the Ltn1 E3 ligase
protects 60S ribosomes from
starvation-induced selective autophagy 909
Ruchika Anand and
Timothy Wai and
Michael J. Baker and
Nikolay Kladt and
Astrid C. Schauss and
Elena Rugarli and
Thomas Langer The i -AAA protease YME1L and OMA1
cleave OPA1 to balance mitochondrial
fusion and fission . . . . . . . . . . . 919
Umut Sahin and
Omar Ferhi and
Marion Jeanne and
Shirine Benhenda and
Caroline Berthier and
Florence Jollivet and
Michiko Niwa-Kawakita and
Orestis Faklaris and
Niclas Setterblad and
Hugues de Thé and
Valérie Lallemand-Breitenbach Oxidative stress--induced assembly of
PML nuclear bodies controls sumoylation
of partner proteins . . . . . . . . . . 931
Budhaditya Banerjee and
Cortney A. Kestner and
P. Todd Stukenberg EB1 enables spindle microtubules to
regulate centromeric recruitment of
Aurora B . . . . . . . . . . . . . . . . 947
Rania S. Rizk and
Katherine A. DiScipio and
Kathleen G. Proudfoot and
Mohan L. Gupta The kinesin-8 Kip3 scales anaphase
spindle length by suppression of midzone
microtubule polymerization . . . . . . . 965
Matthew Akamatsu and
Julien Berro and
Kai-Ming Pu and
Irene R. Tebbs and
Thomas D. Pollard Cytokinetic nodes in fission yeast arise
from two distinct types of nodes that
merge during interphase . . . . . . . . 977
Ewa Bielska and
Martin Schuster and
Yvonne Roger and
Adokiye Berepiki and
Darren M. Soanes and
Nicholas J. Talbot and
Gero Steinberg Hook is an adapter that coordinates
kinesin-3 and dynein cargo attachment on
early endosomes . . . . . . . . . . . . 989
Jun Zhang and
Rongde Qiu and
Herbert N. Arst and
Miguel A. Peñalva and
Xin Xiang HookA is a novel dynein--early endosome
linker critical for cargo movement in
vivo . . . . . . . . . . . . . . . . . . 1009
Evgeny Zatulovskiy and
Richard Tyson and
Till Bretschneider and
Robert R. Kay Bleb-driven chemotaxis of
\bionameDictyostelium cells . . . . . . 1027
Effie Bastounis and
Ruedi Meili and
Begoña Álvarez-González and
Joshua Francois and
Juan C. del Álamo and
Richard A. Firtel and
Juan C. Lasheras Both contractile axial and lateral
traction force dynamics drive amoeboid
cell motility . . . . . . . . . . . . . 1045
Jung Ha Kim and
Kabsun Kim and
Bang Ung Youn and
Jongwon Lee and
Inyoung Kim and
Hong-In Shin and
Haruhiko Akiyama and
Yongwon Choi and
Nacksung Kim Kruppel-like factor 4 attenuates
osteoblast formation, function, and
cross talk with osteoclasts . . . . . . 1063
Vincent Gaggioli and
Eva Zeiser and
David Rivers and
Charles R. Bradshaw and
Julie Ahringer and
Philip Zegerman CDK phosphorylation of SLD-2 is required
for replication initiation and germline
development in \bionameC. elegans . . . 1075
Ben Short SUN proteins melt the nuclear envelope ??
Ben Short Dynamin loss bulks up endocytosis . . . ??
Ben Short p73 helps developing sperm stick to the
right path . . . . . . . . . . . . . . . ??
Ben Short p53 cuts off invading cells . . . . . . 1079
Caitlin Sedwick Melina Schuh: First comes the egg . . . 1080
Nikolaus Pfanner and
Martin van der Laan and
Paolo Amati and
Roderick A. Capaldi and
Amy A. Caudy and
Agnieszka Chacinska and
Manjula Darshi and
Markus Deckers and
Suzanne Hoppins and
Tateo Icho and
Stefan Jakobs and
Jianguo Ji and
Vera Kozjak-Pavlovic and
Chris Meisinger and
Paul R. Odgren and
Sang Ki Park and
Peter Rehling and
Andreas S. Reichert and
M. Saeed Sheikh and
Susan S. Taylor and
Nobuo Tsuchida and
Alexander M. van der Bliek and
Ida J. van der Klei and
Jonathan S. Weissman and
Benedikt Westermann and
Jiping Zha and
Walter Neupert and
Jodi Nunnari Uniform nomenclature for the
mitochondrial contact site and cristae
organizing system . . . . . . . . . . . 1083
Zu-Hang Sheng Mitochondrial trafficking and anchoring
in neurons: New insight and implications 1087
Yagmur Turgay and
Lysie Champion and
Csaba Balazs and
Michael Held and
Alberto Toso and
Daniel W. Gerlich and
Patrick Meraldi and
Ulrike Kutay SUN proteins facilitate the removal of
membranes from chromatin during nuclear
envelope breakdown . . . . . . . . . . . 1099
Emmanuel Gallaud and
Renaud Caous and
Aude Pascal and
Franck Bazile and
Jean-Philippe Gagné and
Sébastien Huet and
Guy G. Poirier and
Denis Chrétien and
Laurent Richard-Parpaillon and
Régis Giet Ensconsin\slash Map7 promotes
microtubule growth and centrosome
separation in \bionameDrosophila neural
stem cells . . . . . . . . . . . . . . . 1111
Madhurima Dhara and
Antonio Yarzagaray and
Yvonne Schwarz and
Soumyajit Dutta and
Chad Grabner and
Paanteha K. Moghadam and
Anneka Bost and
Claudia Schirra and
Jens Rettig and
Kerstin Reim and
Nils Brose and
Ralf Mohrmann and
Dieter Bruns Complexin synchronizes primed vesicle
exocytosis and regulates fusion pore
dynamics . . . . . . . . . . . . . . . . 1123
Jaroslaw Kasprowicz and
Sabine Kuenen and
Jef Swerts and
Katarzyna Miskiewicz and
Patrik Verstreken Dynamin photoinactivation blocks
Clathrin and $ \alpha $-adaptin
recruitment and induces bulk membrane
retrieval . . . . . . . . . . . . . . . 1141
Shannon L. Ballard and
Daniel L. Miller and
Barry Ganetzky Retrograde neurotrophin signaling
through Tollo regulates synaptic growth
in \bionameDrosophila . . . . . . . . . 1157
Lena Holembowski and
Daniela Kramer and
Dietmar Riedel and
Raffaella Sordella and
Alice Nemajerova and
Matthias Dobbelstein and
Ute M. Moll TAp73 is essential for germ cell
adhesion and maturation in testis . . . 1173
Shota Yamauchi and
Yan Yan Hou and
Alvin Kunyao Guo and
Hiroaki Hirata and
Wataru Nakajima and
Ai Kia Yip and
Cheng-han Yu and
Ichiro Harada and
Keng-Hwee Chiam and
Yasuhiro Sawada and
Nobuyuki Tanaka and
Keiko Kawauchi p53-mediated activation of the
mitochondrial protease HtrA2/Omi
prevents cell invasion . . . . . . . . . 1191
Elliott J. Hagedorn and
Laura C. Kelley and
Kaleb M. Naegeli and
Zheng Wang and
Qiuyi Chi and
David R. Sherwood ADF\slash cofilin promotes invadopodial
membrane recycling during cell invasion
in vivo . . . . . . . . . . . . . . . . 1209
Bradley A. Heller and
Monica Ghidinelli and
Jakob Voelkl and
Steven Einheber and
Ryan Smith and
Ethan Grund and
Grant Morahan and
David Chandler and
Luba Kalaydjieva and
Filippo Giancotti and
Rosalind H. King and
Aniko Naray Fejes-Toth and
Gerard Fejes-Toth and
Maria Laura Feltri and
Florian Lang and
James L. Salzer Functionally distinct PI $3$-kinase
pathways regulate myelination in the
peripheral nervous system . . . . . . . 1219
Ben Short Tat substrates open the portal . . . . . ??
Ben Short Protein coat keeps axons buttoned up . . ??
Ben Short Probing PtdIns4 P 's localization . . . ??
Ben Short First remodel, then recycle . . . . . . 3
Caitlin Sedwick Matthew Freeman: The sharp end of
rhomboids . . . . . . . . . . . . . . . 4
Stefano Vavassori and
Andreas Mayer A new life for an old pump: V--ATPase
and neurotransmitter release . . . . . . 7
Markus Babst Quality control at the plasma membrane:
One mechanism does not fit all . . . . . 11
Dong Wang and
Daniel Epstein and
Ossama Khalaf and
Sankaranarayanan Srinivasan and
W. Ryan Williamson and
Amir Fayyazuddin and
Florante A. Quiocho and
P. Robin Hiesinger Ca$^{2+}$-Calmodulin regulates SNARE
assembly and spontaneous
neurotransmitter release via v-ATPase
subunit V0a1 . . . . . . . . . . . . . . 21
Manuel Alonso Y. Adell and
Georg F. Vogel and
Mehrshad Pakdel and
Martin Müller and
Herbert Lindner and
Michael W. Hess and
David Teis Coordinated binding of Vps4 to
ESCRT--III drives membrane neck
constriction during MVB vesicle
formation . . . . . . . . . . . . . . . 33
Cassie Aldridge and
Xianyue Ma and
Fabien Gerard and
Kenneth Cline Substrate-gated docking of pore subunit
Tha4 in the TatC cavity initiates Tat
translocase assembly . . . . . . . . . . 51
Steven L. Jones and
Farida Korobova and
Tatyana Svitkina Axon initial segment cytoskeleton
comprises a multiprotein submembranous
coat containing sparse actin filaments 67
Dylan T. Burnette and
Lin Shao and
Carolyn Ott and
Ana M. Pasapera and
Robert S. Fischer and
Michelle A. Baird and
Christelle Der Loughian and
Helene Delanoe-Ayari and
Matthew J. Paszek and
Michael W. Davidson and
Eric Betzig and
Jennifer Lippincott-Schwartz A contractile and counterbalancing
adhesion system controls the $3$D shape
of crawling cells . . . . . . . . . . . 83
C. Florian Bentzinger and
Julia von Maltzahn and
Nicolas A. Dumont and
Danny A. Stark and
Yu Xin Wang and
Kevin Nhan and
Jérôme Frenette and
D. D. W. Cornelison and
Michael A. Rudnicki Wnt7a stimulates myogenic stem cell
motility and engraftment resulting in
improved muscle strength . . . . . . . . 97
Gerald R. V. Hammond and
Matthias P. Machner and
Tamas Balla A novel probe for phosphatidylinositol
$4$-phosphate reveals multiple pools
beyond the Golgi . . . . . . . . . . . . 113
Mitch Leslie TRIM9 cuts back on axon branching . . . ??
Mitch Leslie Closing the calcium floodgates . . . . . ??
Mitch Leslie Talin holds tight during cell spreading ??
Mitch Leslie Not all vinculins are created equal . . 129
Caitlin Sedwick Alex Mogilner: Math illuminates biology 130
Emily Hatch and
Martin Hetzer Breaching the nuclear envelope in
development and disease . . . . . . . . 133
Lesley A. Kane and
Michael Lazarou and
Adam I. Fogel and
Yan Li and
Koji Yamano and
Shireen A. Sarraf and
Soojay Banerjee and
Richard J. Youle PINK1 phosphorylates ubiquitin to
activate Parkin E3 ubiquitin ligase
activity . . . . . . . . . . . . . . . . 143
Ayelet Lesman and
Jacob Notbohm and
David A. Tirrell and
Guruswami Ravichandran Contractile forces regulate cell
division in three-dimensional
environments . . . . . . . . . . . . . . 155
Julian Scherer and
Julie Yi and
Richard B. Vallee PKA-dependent dynein switching from
lysosomes to adenovirus: a novel form of
host--virus competition . . . . . . . . 163
Verónica Eisner and
Guy Lenaers and
György Hajnóczky Mitochondrial fusion is frequent in
skeletal muscle and supports
excitation--contraction coupling . . . . 179
Katharina Schneider and
Eric Seemann and
Lutz Liebmann and
Rashmi Ahuja and
Dennis Koch and
Martin Westermann and
Christian A. Hübner and
Michael M. Kessels and
Britta Qualmann ProSAP1 and membrane
nanodomain-associated syndapin I promote
postsynapse formation and function . . . 197
Cortney C. Winkle and
Leslie M. McClain and
Juli G. Valtschanoff and
Charles S. Park and
Christopher Maglione and
Stephanie L. Gupton A novel Netrin-1--sensitive mechanism
promotes local SNARE-mediated exocytosis
during axon branching . . . . . . . . . 217
Pascal Béguin and
Kazuaki Nagashima and
Ramasubbu N. Mahalakshmi and
Réjan Vigot and
Atsuko Matsunaga and
Takafumi Miki and
Mei Yong Ng and
Yu Jin Alvin Ng and
Chiaw Hwee Lim and
Hock Soon Tay and
Le-Ann Hwang and
Dmitri Firsov and
Bor Luen Tang and
Nobuya Inagaki and
Yasuo Mori and
Susumu Seino and
Thomas Launey and
Walter Hunziker BARP suppresses voltage-gated calcium
channel activity and Ca$^{2+}$-evoked
exocytosis . . . . . . . . . . . . . . . 233
Jennifer L. Bays and
Xiao Peng and
Catlin E. Tolbert and
Christophe Guilluy and
Ashley E. Angell and
Yuan Pan and
Richard Superfine and
Keith Burridge and
Kris A. DeMali Vinculin phosphorylation differentially
regulates mechanotransduction at
cell--cell and cell--matrix adhesions 251
Perrine Pinon and
Jenita Pärssinen and
Patricia Vazquez and
Michael Bachmann and
Rolle Rahikainen and
Marie-Claude Jacquier and
Latifeh Azizi and
Juha A. Määttä and
Martin Bastmeyer and
Vesa P. Hytönen and
Bernhard Wehrle-Haller Talin-bound NPLY motif recruits
integrin-signaling adapters to regulate
cell spreading and mechanosensing . . . 265
Ben Short Spindle microtubules sustain the tension ??
Ben Short The fellowship of the Rng . . . . . . . ??
Ben Short Tenascin-X and the pick of destiny . . . ??
Ben Short Clathrin's muscle-building regimen . . . 285
Caitlin Sedwick Carole Parent: Migrating cells relay the
message . . . . . . . . . . . . . . . . 286
Brody Holohan and
Woodring E. Wright and
Jerry W. Shay Telomeropathies: an emerging spectrum
disorder . . . . . . . . . . . . . . . . 289
Kim G. Lieu and
Eun-Hee Shim and
Jinling Wang and
Ravi K. Lokareddy and
Tao Tao and
Gino Cingolani and
Gerard P. Zambetti and
David A. Jans The p53-induced factor Ei24 inhibits
nuclear import through an importin $
\beta $-binding-like domain . . . . . . 301
Jeremy M. Chacón and
Soumya Mukherjee and
Breanna M. Schuster and
Duncan J. Clarke and
Melissa K. Gardner Pericentromere tension is self-regulated
by spindle structure in metaphase . . . 313
Jianhua Huang and
Daniel Kalderon Coupling of Hedgehog and Hippo pathways
promotes stem cell maintenance by
stimulating proliferation . . . . . . . 325
Eleni Petsalaki and
George Zachos Chk2 prevents mitotic exit when the
majority of kinetochores are unattached 339
Ning Wang and
Libera Lo Presti and
Yi-Hua Zhu and
Minhee Kang and
Zhengrong Wu and
Sophie G. Martin and
Jian-Qiu Wu The novel proteins Rng8 and Rng9
regulate the myosin--V Myo51 during
fission yeast cytokinesis . . . . . . . 357
Stéphane Vassilopoulos and
Christel Gentil and
Jeanne Lainé and
Pierre-Olivier Buclez and
Agathe Franck and
Arnaud Ferry and
Guillaume Précigout and
Robyn Roth and
John E. Heuser and
Frances M. Brodsky and
Luis Garcia and
Gis\`ele Bonne and
Thomas Voit and
France Piétri-Rouxel and
Marc Bitoun Actin scaffolding by clathrin heavy
chain is required for skeletal muscle
sarcomere organization . . . . . . . . . 377
Alessandra Reversi and
Eva Loeser and
Devaraj Subramanian and
Carsten Schultz and
Stefano De Renzis Plasma membrane phosphoinositide balance
regulates cell shape during
\bionameDrosophila embryo morphogenesis 395
Lindsay B. Alcaraz and
Jean-Yves Exposito and
Nicolas Chuvin and
Roxane M. Pommier and
Caroline Cluzel and
Sylvie Martel and
Stéphanie Sentis and
Laurent Bartholin and
Claire Lethias and
Ulrich Valcourt Tenascin-X promotes
epithelial-to-mesenchymal transition by
activating latent TGF-$ \beta $ . . . . 409
Ben Short Keeping DNA replication below PAR . . . ??
Ben Short Late endosomes uproot focal adhesions ??
Ben Short The spindle checkpoint's on-off switch ??
Ben Short Mitochondrial caspase keeps autophagy in
flux . . . . . . . . . . . . . . . . . . 431
Caitlin Sedwick Peter Cullen: Nexins have it sorted . . 432
Koji Okamoto Organellophagy: Eliminating cellular
building blocks via selective autophagy 435
Laura Benkemoun and
Catherine Descoteaux and
Nicolas T. Chartier and
Lionel Pintard and
Jean-Claude Labbé PAR-4\slash LKB1 regulates DNA
replication during asynchronous division
of the early \bionameC. elegans embryo 447
Dipen Rajgor and
Jason A. Mellad and
Daniel Soong and
Jerome B. Rattner and
Marvin J. Fritzler and
Catherine M. Shanahan Mammalian microtubule P-body dynamics
are mediated by nesprin-1 . . . . . . . 457
Lindsay DeVorkin and
Nancy Erro Go and
Ying-Chen Claire Hou and
Annie Moradian and
Gregg B. Morin and
Sharon M. Gorski The \bionameDrosophila effector caspase
Dcp-1 regulates mitochondrial dynamics
and autophagic flux via SesB . . . . . . 477
Ilham A. Muslimov and
Aliya Tuzhilin and
Thean Hock Tang and
Robert K. S. Wong and
Riccardo Bianchi and
Henri Tiedge Interactions of noncanonical motifs with
hnRNP A2 promote activity-dependent RNA
transport in neurons . . . . . . . . . . 493
Markus Hildenbeutel and
Eric L. Hegg and
Katharina Stephan and
Steffi Gruschke and
Brigitte Meunier and
Martin Ott Assembly factors monitor sequential
hemylation of cytochrome b to regulate
mitochondrial translation . . . . . . . 511
Natalia Schiefermeier and
Julia M. Scheffler and
Mariana E. G. de Araujo and
Taras Stasyk and
Teodor Yordanov and
Hannes L. Ebner and
Martin Offterdinger and
Sebastian Munck and
Michael W. Hess and
Sara A. Wickström and
Anika Lange and
Winfried Wunderlich and
Reinhard Fässler and
David Teis and
Lukas A. Huber The late endosomal p14--MP1 (LAMTOR2/3)
complex regulates focal adhesion
dynamics during cell migration . . . . . 525
Daniel R. Matson and
P. Todd Stukenberg CENP-I and Aurora B act as a molecular
switch that ties RZZ/Mad1 recruitment to
kinetochore attachment status . . . . . 541
Caroline Funk and
Verena Schmeiser and
Jennifer Ortiz and
Johannes Lechner A TOGL domain specifically targets yeast
CLASP to kinetochores to stabilize
kinetochore microtubules . . . . . . . . 555
Aleksandra Tata and
David C. Stoppel and
Shangyu Hong and
Ayal Ben-Zvi and
Tiao Xie and
Chenghua Gu An image-based RNAi screen identifies
SH3BP1 as a key effector of Semaphorin
3E--PlexinD1 signaling . . . . . . . . . 573
Natalia H. Revelo and
Dirk Kamin and
Sven Truckenbrodt and
Aaron B. Wong and
Kirsten Reuter-Jessen and
Ellen Reisinger and
Tobias Moser and
Silvio O. Rizzoli A new probe for super-resolution imaging
of membranes elucidates trafficking
pathways . . . . . . . . . . . . . . . . 591
Ben Short Talin's invasive side . . . . . . . . . ??
Ben Short Harvesting a new KASH crop . . . . . . . ??
Ben Short Endocytosis in its natural state . . . . ??
Ben Short CNTD1's crossover act . . . . . . . . . 609
Caitlin Sedwick Adam Cohen: Visualizing cellular voltage 610
Anthony K. L. Leung Poly(ADP-ribose): an organizer of
cellular architecture . . . . . . . . . 613
David J. Erle and
Dean Sheppard The cell biology of asthma . . . . . . . 621
J. Kim Holloway and
Xianfei Sun and
Rayka Yokoo and
Anne M. Villeneuve and
Paula E. Cohen Mammalian CNTD1 is critical for meiotic
crossover maturation and deselection of
excess precrossover sites . . . . . . . 633
Soumitra Sau and
Michael N. Conrad and
Chih-Ying Lee and
David B. Kaback and
Michael E. Dresser and
Makkuni Jayaram A selfish DNA element engages a
meiosis-specific motor and telomeres for
germ-line propagation . . . . . . . . . 643
Tyler J. Broering and
Kris G. Alavattam and
Ruslan I. Sadreyev and
Yosuke Ichijima and
Yasuko Kato and
Kazuteru Hasegawa and
R. Daniel Camerini-Otero and
Jeannie T. Lee and
Paul R. Andreassen and
Satoshi H. Namekawa BRCA1 establishes DNA damage signaling
and pericentric heterochromatin of the X
chromosome in male meiosis . . . . . . . 663
Xiao Zhou and
Katja Graumann and
Lennart Wirthmueller and
Jonathan D. G. Jones and
Iris Meier Identification of unique SUN-interacting
nuclear envelope proteins with diverse
functions in plants . . . . . . . . . . 677
Ishu Saraogi and
David Akopian and
Shu-ou Shan Regulation of cargo recognition,
commitment, and unloading drives
cotranslational protein targeting . . . 693
Andreas Gerondopoulos and
Ricardo Nunes Bastos and
Shin-ichiro Yoshimura and
Rachel Anderson and
Sarah Carpanini and
Irene Aligianis and
Mark T. Handley and
Francis A. Barr Rab18 and a Rab18 GEF complex are
required for normal ER structure . . . . 707
Alexandre Grassart and
Aaron T. Cheng and
Sun Hae Hong and
Fan Zhang and
Nathan Zenzer and
Yongmei Feng and
David M. Briner and
Gregory D. Davis and
Dmitry Malkov and
David G. Drubin Actin and dynamin2 dynamics and
interplay during clathrin-mediated
endocytosis . . . . . . . . . . . . . . 721
Brian T. Beaty and
Yarong Wang and
Jose Javier Bravo-Cordero and
Ved P. Sharma and
Veronika Miskolci and
Louis Hodgson and
John Condeelis Talin regulates moesin--NHE--1
recruitment to invadopodia and promotes
mammary tumor metastasis . . . . . . . . 737
Mitch Leslie Mps1 sends condensin II off to work . . ??
Mitch Leslie How sperm get into the zona . . . . . . ??
Mitch Leslie SPP pulls an inside job . . . . . . . . ??
Mitch Leslie A different angle on cell division . . . 755
Caitlin Sedwick Fernando Martín--Belmonte: Epithelia
embrace the space . . . . . . . . . . . 756
William A. Prinz Bridging the gap: Membrane contact sites
in signaling, metabolism, and organelle
dynamics . . . . . . . . . . . . . . . . 759
Arnaud Obri and
Munevver Parla Makinistoglu and
Hong Zhang and
Gerard Karsenty HDAC4 integrates PTH and sympathetic
signaling in osteoblasts . . . . . . . . 771
Yuya Kagami and
Keishi Nihira and
Shota Wada and
Masaya Ono and
Mariko Honda and
Kiyotsugu Yoshida Mps1 phosphorylation of condensin II
controls chromosome condensation at the
onset of mitosis . . . . . . . . . . . . 781
Mickael Machicoane and
Cristina A. de Frutos and
Jenny Fink and
Murielle Rocancourt and
Yannis Lombardi and
Sonia Garel and
Matthieu Piel and
Arnaud Echard SLK-dependent activation of ERMs
controls LGN--NuMA localization and
spindle orientation . . . . . . . . . . 791
Matteo A. Avella and
Boris Baibakov and
Jurrien Dean A single domain of the ZP2 zona
pellucida protein mediates gamete
recognition in mice and humans . . . . . 801
Jinhua Han and
Ting Liu and
Michael S. Y. Huen and
Lin Hu and
Zhiqiu Chen and
Jun Huang SIVA1 directs the E3 ubiquitin ligase
RAD18 for PCNA monoubiquitination . . . 811
Jackson Taylor and
Andrea Pereyra and
Tan Zhang and
Maria Laura Messi and
Zhong-Min Wang and
Claudia Hereñú and
Pei-Fen Kuan and
Osvaldo Delbono The Ca$_v$ $ \beta_{1a}$ subunit
regulates gene expression and suppresses
myogenin in muscle progenitor cells . . 829
Jessica M. Boname and
Stuart Bloor and
Michal P. Wandel and
James A. Nathan and
Robin Antrobus and
Kevin S. Dingwell and
Teresa L. Thurston and
Duncan L. Smith and
James C. Smith and
Felix Randow and
Paul J. Lehner Cleavage by signal peptide peptidase is
required for the degradation of selected
tail-anchored proteins . . . . . . . . . 847
Ben Short Budding yeast do the Cdc42 two-step . . ??
Ben Short The fluid dynamics of collective cell
migration . . . . . . . . . . . . . . . ??
Ben Short A short Anillin opens the way for
germline development . . . . . . . . . . ??
Ben Short Defining the kinetochore's rules of
engagement . . . . . . . . . . . . . . . 3
Caitlin Sedwick Sally Kornbluth: Nature's incredible
contraptions . . . . . . . . . . . . . . 4
Anke Treuner-Lange and
Lotte Sògaard-Andersen Regulation of cell polarity in bacteria 7
Pil Jung Kang and
Mid Eum Lee and
Hay-Oak Park Bud3 activates Cdc42 to establish a
proper growth site in budding yeast . . 19
Michael Ensminger and
Lucie Iloff and
Christian Ebel and
Teodora Nikolova and
Bernd Kaina and
Markus Löbrich DNA breaks and chromosomal aberrations
arise when replication meets base
excision repair . . . . . . . . . . . . 29
Anatoly V. Zaytsev and
Lynsie J. R. Sundin and
Keith F. DeLuca and
Ekaterina L. Grishchuk and
Jennifer G. DeLuca Accurate phosphoregulation of
kinetochore--microtubule affinity
requires unconstrained molecular
interactions . . . . . . . . . . . . . . 45
Sergio A. Rincon and
Payal Bhatia and
Claudia Bicho and
Merc\`e Guzman-Vendrell and
Vincent Fraisier and
Weronika E. Borek and
Flavia de Lima Alves and
Florent Dingli and
Damarys Loew and
Juri Rappsilber and
Kenneth E. Sawin and
Sophie G. Martin and
Anne Paoletti Pom1 regulates the assembly of
Cdr2--Mid1 cortical nodes for robust
spatial control of cytokinesis . . . . . 61
Govind Kunduri and
Changqing Yuan and
Velayoudame Parthibane and
Katherine M. Nyswaner and
Ritu Kanwar and
Kunio Nagashima and
Steven G. Britt and
Nickita Mehta and
Varshika Kotu and
Mindy Porterfield and
Michael Tiemeyer and
Patrick J. Dolph and
Usha Acharya and
Jairaj K. Acharya Phosphatidic acid phospholipase A1
mediates ER--Golgi transit of a family
of G protein-coupled receptors . . . . . 79
Alexander Braun and
Kyvan Dang and
Felinah Buslig and
Michelle A. Baird and
Michael W. Davidson and
Clare M. Waterman and
Kenneth A. Myers Rac1 and Aurora A regulate MCAK to
polarize microtubule growth in migrating
endothelial cells . . . . . . . . . . . 97
Sei Kuriyama and
Eric Theveneau and
Alexandre Benedetto and
Maddy Parsons and
Masamitsu Tanaka and
Guillaume Charras and
Alexandre Kabla and
Roberto Mayor In vivo collective cell migration
requires an LPAR2-dependent increase in
tissue fluidity . . . . . . . . . . . . 113
Rana Amini and
Eugénie Goupil and
Sara Labella and
Monique Zetka and
Amy S. Maddox and
Jean-Claude Labbé and
Nicolas T. Chartier \bionameC. elegans Anillin proteins
regulate intercellular bridge stability
and germline syncytial organization . . 129
Ben Short Exploring the LINC to nuclear envelope
spacing . . . . . . . . . . . . . . . . ??
Ben Short GAAC pathway limits autophagy to a light
snack . . . . . . . . . . . . . . . . . ??
Ben Short Deubiquitination helps Rad18 grow more
tolerant . . . . . . . . . . . . . . . . ??
Ben Short Lipids help epithelia stand tall . . . . 147
Caitlin Sedwick Gohta Goshima: Questing for answers on
the mitotic spindle . . . . . . . . . . 148
Xi Huang and
Lily Yeh Jan Targeting potassium channels in cancer 151
Natalie E. Cain and
Erin C. Tapley and
Kent L. McDonald and
Benjamin M. Cain and
Daniel A. Starr The SUN protein UNC-84 is required only
in force-bearing cells to maintain
nuclear envelope architecture . . . . . 163
Rui Chen and
Yilong Zou and
Dongxue Mao and
Daxiao Sun and
Guanguang Gao and
Jingwen Shi and
Xiaoqing Liu and
Chen Zhu and
Mingyu Yang and
Wanlu Ye and
Qianqian Hao and
Ruiqiang Li and
Li Yu The general amino acid control pathway
regulates mTOR and autophagy during
serum/glutamine starvation . . . . . . . 173
Michelle K. Zeman and
Jia-Ren Lin and
Raimundo Freire and
Karlene A. Cimprich DNA damage-specific deubiquitination
regulates Rad18 functions to suppress
mutagenesis . . . . . . . . . . . . . . 183
Imre Gaspar and
Yanxun V. Yu and
Sean L. Cotton and
Dae-Hwan Kim and
Anne Ephrussi and
Michael A. Welte Klar ensures thermal robustness of oskar
localization by restraining RNP motility 199
Haidong Huang and
Yujing Li and
Keith E. Szulwach and
Guoqiang Zhang and
Peng Jin and
Dahua Chen AGO3 Slicer activity regulates
mitochondria--nuage localization of
Armitage and piRNA amplification . . . . 217
Vitali Sikirzhytski and
Valentin Magidson and
Jonathan B. Steinman and
Jie He and
Maël Le Berre and
Irina Tikhonenko and
Jeffrey G. Ault and
Bruce F. McEwen and
James K. Chen and
Haixin Sui and
Matthieu Piel and
Tarun M. Kapoor and
Alexey Khodjakov Direct kinetochore--spindle pole
connections are not required for
chromosome segregation . . . . . . . . . 231
Mary Williard Elting and
Christina L. Hueschen and
Dylan B. Udy and
Sophie Dumont Force on spindle microtubule minus ends
moves chromosomes . . . . . . . . . . . 245
Erich J. Kushner and
Luke S. Ferro and
Jie-Yu Liu and
Jessica R. Durrant and
Stephen L. Rogers and
Andrew C. Dudley and
Victoria L. Bautch Excess centrosomes disrupt endothelial
cell migration via centrosome scattering 257
Meng He and
Khadar M. Abdi and
Vann Bennett Ankyrin-G palmitoylation and $ \beta
$II-spectrin binding to phosphoinositide
lipids drive lateral membrane assembly 273
Motiur Rahman and
Niraj K. Nirala and
Alka Singh and
Lihua Julie Zhu and
Kaori Taguchi and
Takeshi Bamba and
Eiichiro Fukusaki and
Leslie M. Shaw and
David G. Lambright and
Jairaj K. Acharya and
Usha R. Acharya \bionameDrosophila Sirt2/mammalian SIRT3
deacetylates ATP synthase $ \beta $ and
regulates complex V activity . . . . . . 289
Emanuela Frittoli and
Andrea Palamidessi and
Paola Marighetti and
Stefano Confalonieri and
Fabrizio Bianchi and
Chiara Malinverno and
Giovanni Mazzarol and
Giuseppe Viale and
Ines Martin-Padura and
Massimilliano Garré and
Dario Parazzoli and
Valentina Mattei and
Salvatore Cortellino and
Giovanni Bertalot and
Pier Paolo Di Fiore and
Giorgio Scita A RAB5/RAB4 recycling circuitry induces
a proteolytic invasive program and
promotes tumor dissemination . . . . . . 307
Mitch Leslie Lipid droplets ensure their own
consumption . . . . . . . . . . . . . . ??
Mitch Leslie Loss of protein remodels shape-shifting
parasite . . . . . . . . . . . . . . . . ??
Mitch Leslie Paxillin brings peace to microtubules ??
Mitch Leslie CLAMPing down on microtubules in
migratory cells . . . . . . . . . . . . 331
Caitlin Sedwick Buzz Baum: The art of cell shape . . . . 332
Mikael Simons and
Thomas Misgeld and
Martin Kerschensteiner A unified cell biological perspective on
axon--myelin injury . . . . . . . . . . 335
Satoshi Ninagawa and
Tetsuya Okada and
Yoshiki Sumitomo and
Yukiko Kamiya and
Koichi Kato and
Satoshi Horimoto and
Tokiro Ishikawa and
Shunichi Takeda and
Tetsushi Sakuma and
Takashi Yamamoto and
Kazutoshi Mori EDEM2 initiates mammalian glycoprotein
ERAD by catalyzing the first mannose
trimming step . . . . . . . . . . . . . 347
Chao-Wen Wang and
Yu-Hsuan Miao and
Yi-Shun Chang A sterol-enriched vacuolar microdomain
mediates stationary phase lipophagy in
budding yeast . . . . . . . . . . . . . 357
Michael E. Werner and
Jennifer W. Mitchell and
William Putzbach and
Elizabeth Bacon and
Sun K. Kim and
Brian J. Mitchell Radial intercalation is regulated by the
Par complex and the
microtubule-stabilizing protein
CLAMP/Spef1 . . . . . . . . . . . . . . 367
Polly Hayes and
Vladimir Varga and
Sofia Olego-Fernandez and
Jack Sunter and
Michael L. Ginger and
Keith Gull Modulation of a cytoskeletal
calpain-like protein induces major
transitions in trypanosome morphology 377
Kara J. Helmke and
Rebecca Heald TPX2 levels modulate meiotic spindle
size and architecture in \bionameXenopus
egg extracts . . . . . . . . . . . . . . 385
Nicholas O. Deakin and
Christopher E. Turner Paxillin inhibits HDAC6 to regulate
microtubule acetylation, Golgi
structure, and polarized migration . . . 395
Paolo Armando Gagliardi and
Laura di Blasio and
Alberto Puliafito and
Giorgio Seano and
Roberto Sessa and
Federica Chianale and
Thomas Leung and
Federico Bussolino and
Luca Primo PDK1-mediated activation of MRCK$ \alpha
$ regulates directional cell migration
and lamellipodia retraction . . . . . . 415
Claudia G. Vasquez and
Mike Tworoger and
Adam C. Martin Dynamic myosin phosphorylation regulates
contractile pulses and tissue integrity
during epithelial morphogenesis . . . . 435
Ben Short MagT1 helps a glycosylase gain
acceptance . . . . . . . . . . . . . . . ??
Ben Short Sperm's sensitive steering machinery . . ??
Ben Short Lasp brings a giant down to size . . . . ??
Ben Short Vps74 gives phosphatase directions . . . 453
Caitlin Sedwick Heidi McBride: Mitochondria are well
connected . . . . . . . . . . . . . . . 454
Kevin D. Corbett and
Arshad Desai A new piece in the kinetochore jigsaw
puzzle . . . . . . . . . . . . . . . . . 457
Carsten Janke The tubulin code: Molecular components,
readout mechanisms, and functions . . . 461
Lisa J. Edens and
Daniel L. Levy cPKC regulates interphase nuclear size
during \bionameXenopus development . . . 473
Yiying Cai and
Yongqiang Deng and
Florian Horenkamp and
Karin M. Reinisch and
Christopher G. Burd Sac1--Vps74 structure reveals a
mechanism to terminate phosphoinositide
signaling in the Golgi apparatus . . . . 485
Anar K. Murphy and
Michael Fitzgerald and
Teresa Ro and
Jee Hyun Kim and
Ariana I. Rabinowitsch and
Dipanjan Chowdhury and
Carl L. Schildkraut and
James A. Borowiec Phosphorylated RPA recruits PALB2 to
stalled DNA replication forks to
facilitate fork recovery . . . . . . . . 493
Peter Hornung and
Paulina Troc and
Francesca Malvezzi and
Michael Maier and
Zuzana Demianova and
Tomasz Zimniak and
Gabriele Litos and
Fabienne Lampert and
Alexander Schleiffer and
Matthias Brunner and
Karl Mechtler and
Franz Herzog and
Thomas C. Marlovits and
Stefan Westermann A cooperative mechanism drives budding
yeast kinetochore assembly downstream of
CENP--A . . . . . . . . . . . . . . . . 509
Natalia A. Cherepanova and
Shiteshu Shrimal and
Reid Gilmore Oxidoreductase activity is necessary for
N-glycosylation of cysteine-proximal
acceptor sites in glycoproteins . . . . 525
Magdalena Pichlo and
Stefanie Bungert-Plümke and
Ingo Weyand and
Reinhard Seifert and
Wolfgang Bönigk and
Timo Strünker and
Nachiket Dilip Kashikar and
Normann Goodwin and
Astrid Müller and
Heinz G. Körschen and
Ursel Collienne and
Patric Pelzer and
Qui Van and
Jörg Enderlein and
Clementine Klemm and
Eberhard Krause and
Christian Trötschel and
Ansgar Poetsch and
Elisabeth Kremmer and
U. Benjamin Kaupp High density and ligand affinity confer
ultrasensitive signal detection by a
guanylyl cyclase chemoreceptor . . . . . 541
Isabelle Fernandes and
Frieder Schöck The nebulin repeat protein Lasp
regulates I-band architecture and
filament spacing in myofibrils . . . . . 559
Ben Short If it ain't broke, don't fix it . . . . ??
Ben Short A replication origin gets SNP'd out in
fragile X syndrome . . . . . . . . . . . ??
Ben Short Sphingomyelin is the master of its
domain . . . . . . . . . . . . . . . . . ??
Ben Short Netrin puts an end to the anchor cell's
vacillations . . . . . . . . . . . . . . 575
Caitlin Sedwick Elizabeth Chen: Fusing cells press
closer . . . . . . . . . . . . . . . . . 576
Jeffrey A. Toretsky and
Peter E. Wright Assemblages: Functional units formed by
cellular phase separation . . . . . . . 579
Salim Ziani and
Zita Nagy and
Sergey Alekseev and
Evi Soutoglou and
Jean-Marc Egly and
Frédéric Coin Sequential and ordered assembly of a
large DNA repair complex on undamaged
chromatin . . . . . . . . . . . . . . . 589
Jeannine Gerhardt and
Nikica Zaninovic and
Qiansheng Zhan and
Advaitha Madireddy and
Sarah L. Nolin and
Nicole Ersalesi and
Zi Yan and
Zev Rosenwaks and
Carl L. Schildkraut Cis-acting DNA sequence at a replication
origin promotes repeat expansion to
fragile X full mutation . . . . . . . . 599
Josse van Galen and
Felix Campelo and
Emma Martínez-Alonso and
Margherita Scarpa and
José Ángel Martínez-Menárguez and
Vivek Malhotra Sphingomyelin homeostasis is required to
form functional enzymatic domains at the
trans-Golgi network . . . . . . . . . . 609
Zheng Wang and
Lara M. Linden and
Kaleb M. Naegeli and
Joshua W. Ziel and
Qiuyi Chi and
Elliott J. Hagedorn and
Natasha S. Savage and
David R. Sherwood UNC-6 (netrin) stabilizes oscillatory
clustering of the UNC-40 (DCC) receptor
to orient polarity . . . . . . . . . . . 619
Christine Kienzle and
Nirakar Basnet and
Alvaro H. Crevenna and
Gisela Beck and
Bianca Habermann and
Naoko Mizuno and
Julia von Blume Cofilin recruits F-actin to SPCA1 and
promotes Ca$^{2+}$-mediated secretory
cargo sorting . . . . . . . . . . . . . 635
Ghazaleh Ashrafi and
Julia S. Schlehe and
Matthew J. LaVoie and
Thomas L. Schwarz Mitophagy of damaged mitochondria occurs
locally in distal neuronal axons and
requires PINK1 and Parkin . . . . . . . 655
Laura Corrigan and
Siamak Redhai and
Aaron Leiblich and
Shih-Jung Fan and
Sumeth M. W. Perera and
Rachel Patel and
Carina Gandy and
S. Mark Wainwright and
John F. Morris and
Freddie Hamdy and
Deborah C. I. Goberdhan and
Clive Wilson BMP-regulated exosomes from
\bionameDrosophila male reproductive
glands reprogram female behavior . . . . 671
Mitch Leslie Mitotic cells' shocking response to
stress . . . . . . . . . . . . . . . . . ??
Mitch Leslie Sec12 heads for the exits . . . . . . . ??
Mitch Leslie ESCRT-III gets the bends . . . . . . . . ??
Mitch Leslie Topoisomerase II has to work late . . . 691
Caitlin Sedwick Margaret Robinson: Vesicles wear fancy
coats . . . . . . . . . . . . . . . . . 692
Fred D. Mast and
Alexander V. Ratushny and
John D. Aitchison Systems cell biology . . . . . . . . . . 695
Mehdi Saadaoui and
Mickaël Machicoane and
Florencia di Pietro and
Fred Etoc and
Arnaud Echard and
Xavier Morin Dlg1 controls planar spindle orientation
in the neuroepithelium through direct
interaction with LGN . . . . . . . . . . 707
Iris Titos and
Tsvetomira Ivanova and
Manuel Mendoza Chromosome length and perinuclear
attachment constrain resolution of DNA
intertwines . . . . . . . . . . . . . . 719
Alexandra N. Elsing and
Camilla Aspelin and
Johanna K. Björk and
Heidi A. Bergman and
Samu V. Himanen and
Marko J. Kallio and
Pia Roos-Mattjus and
Lea Sistonen Expression of HSF2 decreases in mitosis
to enable stress-inducible transcription
and cell survival . . . . . . . . . . . 735
Kota Saito and
Koh Yamashiro and
Noriko Shimazu and
Tomoya Tanabe and
Kenji Kontani and
Toshiaki Katada Concentration of Sec12 at ER exit sites
via interaction with cTAGE5 is required
for collagen export . . . . . . . . . . 751
Qing-Tao Shen and
Amber L. Schuh and
Yuqing Zheng and
Kyle Quinney and
Lei Wang and
Michael Hanna and
Julie C. Mitchell and
Marisa S. Otegui and
Paul Ahlquist and
Qiang Cui and
Anjon Audhya Structural analysis and modeling reveals
new mechanisms governing ESCRT--III
spiral filament assembly . . . . . . . . 763
Dipal M. Patel and
Adi D. Dubash and
Geri Kreitzer and
Kathleen J. Green Disease mutations in desmoplakin inhibit
Cx43 membrane targeting mediated by
desmoplakin--EB1 interactions . . . . . 779
Ying-Ting Zhu and
Fu Li and
Bo Han and
Sean Tighe and
Suzhen Zhang and
Szu-Yu Chen and
Xin Liu and
Scheffer C. G. Tseng Activation of RhoA--ROCK--BMP signaling
reprograms adult human corneal
endothelial cells . . . . . . . . . . . 799
Mitch Leslie Enzyme helps fold the SAC . . . . . . . ??
Mitch Leslie HIV's unkind cut . . . . . . . . . . . . ??
Mitch Leslie DNA repair with a hefty price tag . . . ??
Mitch Leslie A storehouse for splicing proteins? . . 815
Caitlin Sedwick Laura Machesky: Actin opens the way . . 816
Ilia A. Droujinine and
Dong Yan and
Norbert Perrimon A sharp end to sugary Wingless travels 819
Jeremy Nance Getting to know your neighbor: Cell
polarization in early embryos . . . . . 823
Antonio Espert and
Pelin Uluocak and
Ricardo Nunes Bastos and
Davinderpreet Mangat and
Philipp Graab and
Ulrike Gruneberg PP2A-B56 opposes Mps1 phosphorylation of
Knl1 and thereby promotes spindle
assembly checkpoint silencing . . . . . 833
Deepak Adhikari and
M. Kasim Diril and
Kiran Busayavalasa and
Sanjiv Risal and
Shoma Nakagawa and
Rebecca Lindkvist and
Yan Shen and
Vincenzo Coppola and
Lino Tessarollo and
Nobuaki R. Kudo and
Philipp Kaldis and
Kui Liu Mastl is required for timely activation
of APC/C in meiosis I and Cdk1
reactivation in meiosis II . . . . . . . 843
Dong Kong and
Veronica Farmer and
Anil Shukla and
Jana James and
Richard Gruskin and
Shigeo Kiriyama and
Jadranka Loncarek Centriole maturation requires regulated
Plk1 activity during two consecutive
cell cycles . . . . . . . . . . . . . . 855
Amy M. Sainski and
Haiming Dai and
Sekar Natesampillai and
Yuan-Ping Pang and
Gary D. Bren and
Nathan W. Cummins and
Cristina Correia and
X. Wei Meng and
James E. Tarara and
Marina Ramirez-Alvarado and
David J. Katzmann and
Christina Ochsenbauer and
John C. Kappes and
Scott H. Kaufmann and
Andrew D. Badley Casp8p41 generated by HIV protease kills
CD4 T cells through direct Bak
activation . . . . . . . . . . . . . . . 867
Olivia Barton and
Steffen C. Naumann and
Ronja Diemer-Biehs and
Julia Künzel and
Monika Steinlage and
Sandro Conrad and
Nodar Makharashvili and
Jiadong Wang and
Lin Feng and
Bernard S. Lopez and
Tanya T. Paull and
Junjie Chen and
Penny A. Jeggo and
Markus Löbrich Polo-like kinase 3 regulates CtIP during
DNA double-strand break repair in G1 . . 877
Sandy T. Oas and
Anton L. Bryantsev and
Richard M. Cripps Arrest is a regulator of fiber-specific
alternative splicing in the indirect
flight muscles of \bionameDrosophila . . 895
Georg Vogler and
Jiandong Liu and
Timothy W. Iafe and
Ede Migh and
József Mihály and
Rolf Bodmer Cdc42 and formin activity control
non-muscle myosin dynamics during
\bionameDrosophila heart morphogenesis 909
Xiaoxi Wang and
Andrea Page-McCaw A matrix metalloproteinase mediates
long-distance attenuation of stem cell
proliferation . . . . . . . . . . . . . 923
Ben Short A ribonuclease helps the ER get in shape ??
Ben Short Bem1p directs vesicular traffic . . . . ??
Ben Short Chibby's function in the dock . . . . . ??
Ben Short How mitosis keeps itself in order . . . 3
Caitlin Sedwick Raphael Valdivia: How \bionameChlamydia
settles in . . . . . . . . . . . . . . . 4
Alan Hall Always aiming for the best: For
scientists and for science . . . . . . . 7
Robert S. Fischer Move your microvilli . . . . . . . . . . 9
Maija Slaidina and
Ruth Lehmann Translational control in germline stem
cell development . . . . . . . . . . . . 13
Dan Lu and
Jennifer Y. Hsiao and
Norman E. Davey and
Vanessa A. Van Voorhis and
Scott A. Foster and
Chao Tang and
David O. Morgan Multiple mechanisms determine the order
of APC/C substrate degradation in
mitosis . . . . . . . . . . . . . . . . 23
Dianne S. Schwarz and
Michael D. Blower The calcium-dependent ribonuclease
XendoU promotes ER network formation
through local RNA degradation . . . . . 41
Dongmei Liu and
Peter Novick Bem1p contributes to secretory pathway
polarization through a direct
interaction with Exo70p . . . . . . . . 59
Nah-Young Shin and
Hyewon Choi and
Lynn Neff and
Yumei Wu and
Hiroaki Saito and
Shawn M. Ferguson and
Pietro De Camilli and
Roland Baron Dynamin and endocytosis are required for
the fusion of osteoclasts and myoblasts 73
Chikara Tanaka and
Li-Jing Tan and
Keisuke Mochida and
Hiromi Kirisako and
Michiko Koizumi and
Eri Asai and
Machiko Sakoh-Nakatogawa and
Yoshinori Ohsumi and
Hitoshi Nakatogawa Hrr25 triggers selective
autophagy--related pathways by
phosphorylating receptor proteins . . . 91
Christoph Klingner and
Anoop V. Cherian and
Johannes Fels and
Philipp M. Diesinger and
Roland Aufschnaiter and
Nicola Maghelli and
Thomas Keil and
Gisela Beck and
Iva M. Toli\'c-Nòrrelykke and
Mark Bathe and
Roland Wedlich-Soldner Isotropic actomyosin dynamics promote
organization of the apical cell cortex
in epithelial cells . . . . . . . . . . 107
Michael C. Burke and
Feng-Qian Li and
Benjamin Cyge and
Takeshi Arashiro and
Heather M. Brechbuhl and
Xingwang Chen and
Saul S. Siller and
Matthew A. Weiss and
Christopher B. O'Connell and
Damon Love and
Christopher J. Westlake and
Susan D. Reynolds and
Ryoko Kuriyama and
Ken-Ichi Takemaru Chibby promotes ciliary vesicle
formation and basal body docking during
airway cell differentiation . . . . . . 123
Sherry Dadgar and
Zuyi Wang and
Helen Johnston and
Akanchha Kesari and
Kanneboyina Nagaraju and
Yi-Wen Chen and
D. Ashley Hill and
Terence A. Partridge and
Mamta Giri and
Robert J. Freishtat and
Javad Nazarian and
Jianhua Xuan and
Yue Wang and
Eric P. Hoffman Asynchronous remodeling is a driver of
failed regeneration in Duchenne muscular
dystrophy . . . . . . . . . . . . . . . 139
Amy M. Sainski and
Haiming Dai and
Sekar Natesampillai and
Yuan-Ping Pang and
Gary D. Bren and
Nathan W. Cummins and
Cristina Correia and
X. Wei Meng and
James E. Tarara and
Marina Ramirez-Alvarado and
David J. Katzmann and
Christina Ochsenbauer and
John C. Kappes and
Scott H. Kaufmann and
Andrew D. Badley Casp8p41 generated by HIV protease kills
CD4 T cells through direct Bak
activation . . . . . . . . . . . . . . . 159
Ben Short A new CLUH to mitochondrial biogenesis ??
Ben Short Septins provide a link to epithelial
migration . . . . . . . . . . . . . . . ??
Ben Short Acinus cleavage cuts down on autophagy ??
Ben Short TGF-$ \beta $ gets primed for action . . 163
Caitlin Sedwick Guangshuo Ou: New perspectives on Q cell
biology . . . . . . . . . . . . . . . . 164
Erik H. J. Danen Ignoring matrix boundaries when the LKB1
master kinase is gone . . . . . . . . . 167
Danelle Devenport The cell biology of planar cell polarity 171
Katerina Ragkousi and
Matthew C. Gibson Cell division and the maintenance of
epithelial order . . . . . . . . . . . . 181
Chloe E. Snider and
Andrew D. Stephens and
Jacob G. Kirkland and
Omar Hamdani and
Rohinton T. Kamakaka and
Kerry Bloom Dyskerin, tRNA genes, and condensin
tether pericentric chromatin to the
spindle axis in mitosis . . . . . . . . 189
David Kachaner and
Xavier Pinson and
Khaled Ben El Kadhi and
Karine Normandin and
Lama Talje and
Hugo Lavoie and
Guillaume Lépine and
Sébastien Carréno and
Benjamin H. Kwok and
Gilles R. Hickson and
Vincent Archambault Interdomain allosteric regulation of
Polo kinase by Aurora B and Map205 is
required for cytokinesis . . . . . . . . 201
Jie Gao and
Désirée Schatton and
Paola Martinelli and
Henriette Hansen and
David Pla-Martin and
Esther Barth and
Christian Becker and
Janine Altmueller and
Peter Frommolt and
Marco Sardiello and
Elena I. Rugarli CLUH regulates mitochondrial biogenesis
by binding mRNAs of nuclear-encoded
mitochondrial proteins . . . . . . . . . 213
Lee Dolat and
John L. Hunyara and
Jonathan R. Bowen and
Eva Pauline Karasmanis and
Maha Elgawly and
Vitold E. Galkin and
Elias T. Spiliotis Septins promote stress fiber-mediated
maturation of focal adhesions and renal
epithelial motility . . . . . . . . . . 225
Taesun Eom and
Ilham A. Muslimov and
Panayiotis Tsokas and
Valerio Berardi and
Jun Zhong and
Todd C. Sacktor and
Henri Tiedge Neuronal BC RNAs cooperate with eIF4B to
mediate activity-dependent translational
control . . . . . . . . . . . . . . . . 237
Nilay Nandi and
Lauren K. Tyra and
Drew Stenesen and
Helmut Krämer Acinus integrates AKT1 and subapoptotic
caspase activities to regulate basal
autophagy . . . . . . . . . . . . . . . 253
Michael Taschner and
Fruzsina Kotsis and
Philipp Braeuer and
E. Wolfgang Kuehn and
Esben Lorentzen Crystal structures of IFT70/52 and
IFT52/46 provide insight into
intraflagellar transport B core complex
assembly . . . . . . . . . . . . . . . . 269
Franco Klingberg and
Melissa L. Chow and
Anne Koehler and
Stellar Boo and
Lara Buscemi and
Thomas M. Quinn and
Mercedes Costell and
Benjamin A. Alman and
Elisabeth Genot and
Boris Hinz Prestress in the extracellular matrix
sensitizes latent TGF-$ \beta $1 for
activation . . . . . . . . . . . . . . . 283
Keefe T. Chan and
Sreeja B. Asokan and
Samantha J. King and
Tao Bo and
Evan S. Dubose and
Wenjin Liu and
Matthew E. Berginski and
Jeremy M. Simon and
Ian J. Davis and
Shawn M. Gomez and
Norman E. Sharpless and
James E. Bear LKB1 loss in melanoma disrupts
directional migration toward
extracellular matrix cues . . . . . . . 299
Ben Short Satellite RNA guides kinetochore
assembly . . . . . . . . . . . . . . . . ??
Ben Short mTORC2 helps brown adipose tissue fuel
up . . . . . . . . . . . . . . . . . . . ??
Ben Short Building modular motor complexes . . . . ??
Ben Short Red and green traffic signals . . . . . 319
Kendall Powell Dan Fletcher: a recipe for cooking up
cellular machines . . . . . . . . . . . 320
Gary J. Brouhard and
Luke M. Rice The contribution of $ \alpha \beta
$-tubulin curvature to microtubule
dynamics . . . . . . . . . . . . . . . . 323
Silvana Ro\vsi\'c and
Florian Köhler and
Sylvia Erhardt Repetitive centromeric satellite RNA is
essential for kinetochore formation and
cell division . . . . . . . . . . . . . 335
Lydie Couturier and
Mateusz Trylinski and
Khallil Mazouni and
Léa Darnet and
François Schweisguth A fluorescent tagging approach in
\bionameDrosophila reveals late
endosomal trafficking of Notch and
Sanpodo . . . . . . . . . . . . . . . . 351
Jessica M. Olsen and
Masaaki Sato and
Olof S. Dallner and
Anna L. Sandström and
Didier F. Pisani and
Jean-Claude Chambard and
Ez-Zoubir Amri and
Dana S. Hutchinson and
Tore Bengtsson Glucose uptake in brown fat cells is
dependent on mTOR complex $2$--promoted
GLUT1 translocation . . . . . . . . . . 365
Oluwatobi Ogun and
Marisa Zallocchi Clarin-1 acts as a modulator of
mechanotransduction activity and
presynaptic ribbon assembly . . . . . . 375
Stephen R. Norris and
Virupakshi Soppina and
Aslan S. Dizaji and
Kristin I. Schimert and
David Sept and
Dawen Cai and
Sivaraj Sivaramakrishnan and
Kristen J. Verhey A method for multiprotein assembly in
cells reveals independent action of
kinesins in complex . . . . . . . . . . 393
Sara Löchte and
Sharon Waichman and
Oliver Beutel and
Changjiang You and
Jacob Piehler Live cell micropatterning reveals the
dynamics of signaling complexes at the
plasma membrane . . . . . . . . . . . . 407
Yi Shen and
Morgane Rosendale and
Robert E. Campbell and
David Perrais pHuji, a pH-sensitive red fluorescent
protein for imaging of exo- and
endocytosis . . . . . . . . . . . . . . 419
Matthew J. Van Hook and
Caitlyn M. Parmelee and
Minghui Chen and
Karlene M. Cork and
Carina Curto and
Wallace B. Thoreson Calmodulin enhances ribbon replenishment
and shapes filtering of synaptic
transmission by cone photoreceptors . . ??
Mitch Leslie Wait! Don't throw away those proteins! ??
Mitch Leslie DDR1 key for cancer cell escape . . . . ??
Mitch Leslie Melanoma cells travel on calcium cycles ??
Mitch Leslie A molecular chain gang at work in
maturing ribosomes . . . . . . . . . . . 435
Caitlin Sedwick Valentina Greco: Got hair? . . . . . . . 436
Scott W. Crawley and
Mark S. Mooseker and
Matthew J. Tyska Shaping the intestinal brush border . . 441
Ana Clara Fernandes and
Valerie Uytterhoeven and
Sabine Kuenen and
Yu-Chun Wang and
Jan R. Slabbaert and
Jef Swerts and
Jaroslaw Kasprowicz and
Stein Aerts and
Patrik Verstreken Reduced synaptic vesicle protein
degradation at lysosomes curbs
TBC1D24/sky-induced neurodegeneration 453
Jonathan Bizarro and
Christophe Charron and
Séverine Boulon and
Belinda Westman and
Béreng\`ere Pradet-Balade and
Franck Vandermoere and
Marie-Eve Chagot and
Marie Hallais and
Yasmeen Ahmad and
Heinrich Leonhardt and
Angus Lamond and
Xavier Manival and
Christiane Branlant and
Bruno Charpentier and
Céline Verheggen and
Edouard Bertrand Proteomic and $3$D structure analyses
highlight the C/D box snoRNP assembly
mechanism and its control . . . . . . . 463
Jochen Baßler and
Helge Paternoga and
Iris Holdermann and
Matthias Thoms and
Sander Granneman and
Clara Barrio-Garcia and
Afua Nyarko and
Woonghee Lee and
Gunter Stier and
Sarah A. Clark and
Daniel Schraivogel and
Martina Kallas and
Roland Beckmann and
David Tollervey and
Elisar Barbar and
Irmi Sinning and
Ed Hurt A network of assembly factors is
involved in remodeling rRNA elements
during preribosome maturation . . . . . 481
Laura A. Jones and
Cécile Villemant and
Toby Starborg and
Anna Salter and
Georgina Goddard and
Peter Ruane and
Philip G. Woodman and
Nancy Papalopulu and
Sarah Woolner and
Victoria J. Allan Dynein light intermediate chains
maintain spindle bipolarity by
functioning in centriole cohesion . . . 499
Amélie Juin and
Julie Di Martino and
Birgit Leitinger and
Elodie Henriet and
Anne-Sophie Gary and
Lisa Paysan and
Jeremy Bomo and
Georges Baffet and
Cécile Gauthier-Rouvi\`ere and
Jean Rosenbaum and
Violaine Moreau and
Frédéric Saltel Discoidin domain receptor 1 controls
linear invadosome formation via a
Cdc42--Tuba pathway . . . . . . . . . . 517
Jianwei Sun and
Fujian Lu and
Huifang He and
Junling Shen and
Jane Messina and
Rahel Mathew and
Dapeng Wang and
Amod A. Sarnaik and
Wei-Chiao Chang and
Minjung Kim and
Heping Cheng and
Shengyu Yang STIM1- and Orai1-mediated Ca$^{2+}$
oscillation orchestrates invadopodium
formation and melanoma invasion . . . . 535
Mohammed I. Ahmed and
Majid Alam and
Vladimir U. Emelianov and
Krzysztof Poterlowicz and
Ankit Patel and
Andrey A. Sharov and
Andrei N. Mardaryev and
Natalia V. Botchkareva MicroRNA-214 controls skin and hair
follicle development by modulating the
activity of the Wnt pathway . . . . . . 549
Joseph E. Chambers and
Kseniya Petrova and
Giulia Tomba and
Michele Vendruscolo and
David Ron ADP ribosylation adapts an ER chaperone
response to short-term fluctuations in
unfolded protein load . . . . . . . . . 569
Ben Short Macrophages show neutrophils the exit ??
Ben Short CDK5 opens the way for DLC1 . . . . . . ??
Ben Short PIP$_2$ directs vinculin assembly . . . ??
Ben Short Unlocking the secrets of chitinase
secretion . . . . . . . . . . . . . . . 573
Caitlin Sedwick Miklós Müller: The deep history of
eukaryotic metabolism . . . . . . . . . 574
Christopher P. Toret and
Caitlin Collins and
W. James Nelson An Elmo--Dock complex locally controls
Rho GTPases and actin remodeling during
cadherin-mediated adhesion . . . . . . . 577
Sebastien Tauzin and
Taylor W. Starnes and
Francisco Barros Becker and
Pui-ying Lam and
Anna Huttenlocher Redox and Src family kinase signaling
control leukocyte wound attraction and
neutrophil reverse migration . . . . . . 589
Marcel Reuter and
Alex Zelensky and
Ihor Smal and
Erik Meijering and
Wiggert A. van Cappellen and
H. Martijn de Gruiter and
Gijsbert J. van Belle and
Martin E. van Royen and
Adriaan B. Houtsmuller and
Jeroen Essers and
Roland Kanaar and
Claire Wyman BRCA2 diffuses as oligomeric clusters
with RAD51 and changes mobility after
DNA damage in live cells . . . . . . . . 599
Jaeger J. Hamilton and
Victoria L. Marlow and
Richard A. Owen and
Marília de Assis Alcoforado Costa and
Manman Guo and
Grant Buchanan and
Govind Chandra and
Matthias Trost and
Sarah J. Coulthurst and
Tracy Palmer and
Nicola R. Stanley-Wall and
Frank Sargent A holin and an endopeptidase are
essential for chitinolytic protein
secretion in Serratia marcescens . . . . 615
Brajendra K. Tripathi and
Xiaolan Qian and
Philipp Mertins and
Dunrui Wang and
Alex G. Papageorge and
Steven A. Carr and
Douglas R. Lowy CDK5 is a major regulator of the tumor
suppressor DLC1 . . . . . . . . . . . . 627
Krishna Chinthalapudi and
Erumbi S. Rangarajan and
Dipak N. Patil and
Eric M. George and
David T. Brown and
Tina Izard Lipid binding promotes oligomerization
and focal adhesion activity of vinculin 643
Pallavi Bhattaram and
Alfredo Penzo-Méndez and
Kenji Kato and
Kaustav Bandyopadhyay and
Abhilash Gadi and
Makoto M. Taketo and
Véronique Lefebvre SOXC proteins amplify canonical WNT
signaling to secure nonchondrocytic
fates in skeletogenesis . . . . . . . . 657
Silvana Ro\vsi\'c and
Florian Köhler and
Sylvia Erhardt Repetitive centromeric satellite RNA is
essential for kinetochore formation and
cell division . . . . . . . . . . . . . 673
Magdalena Pichlo and
Stefanie Bungert-Plümke and
Ingo Weyand and
Reinhard Seifert and
Wolfgang Bönigk and
Timo Strünker and
Nachiket Dilip Kashikar and
Normann Goodwin and
Astrid Müller and
Heinz G. Körschen and
Ursel Collienne and
Patric Pelzer and
Qui Van and
Jörg Enderlein and
Clementine Klemm and
Eberhard Krause and
Christian Trötschel and
Ansgar Poetsch and
Elisabeth Kremmer and
U. Benjamin Kaupp High density and ligand affinity confer
ultrasensitive signal detection by a
guanylyl cyclase chemoreceptor . . . . . 675
Ben Short KIF4A knows its own limits . . . . . . . ??
Ben Short Understanding the DisAp-pearance of
cilia orientation . . . . . . . . . . . ??
Ben Short Ankyrin aweigh for axonal transport . . ??
Ben Short Osmotic gradient is just the tonic for
wounded epithelia . . . . . . . . . . . 679
Kendall Powell Dominique Bergmann: Passionate about
plant polarity . . . . . . . . . . . . . 680
Ricardo Nunes Bastos and
Michael J. Cundell and
Francis A. Barr KIF4A and PP2A--B56 form a spatially
restricted feedback loop opposing Aurora
B at the anaphase central spindle . . . 683
David Cruz-Garcia and
Amy J. Curwin and
Jean-François Popoff and
Caroline Bruns and
Juan M. Duran and
Vivek Malhotra Remodeling of secretory compartments
creates CUPS during nutrient starvation 695
Domenico F. Galati and
Stephanie Bonney and
Zev Kronenberg and
Christina Clarissa and
Mark Yandell and
Nels C. Elde and
Maria Jerka-Dziadosz and
Thomas H. Giddings and
Joseph Frankel and
Chad G. Pearson DisAp-dependent striated fiber
elongation is required to organize
ciliary arrays . . . . . . . . . . . . . 705
Karolin Klement and
Martijn S. Luijsterburg and
Jordan B. Pinder and
Chad S. Cena and
Victor Del Nero and
Christopher M. Wintersinger and
Graham Dellaire and
Haico van Attikum and
Aaron A. Goodarzi Opposing ISWI- and CHD-class chromatin
remodeling activities orchestrate
heterochromatic DNA repair . . . . . . . 717
Damaris Nadia Lorenzo and
Alexandra Badea and
Jonathan Davis and
Janell Hostettler and
Jiang He and
Guisheng Zhong and
Xiaowei Zhuang and
Vann Bennett A PIK3C3--Ankyrin--B--Dynactin pathway
promotes axonal growth and
multiorganelle transport . . . . . . . . 735
Duo Zhang and
Xiaoyun Wang and
Yuying Li and
Lei Zhao and
Minghua Lu and
Xuan Yao and
Hongfeng Xia and
Yu-cheng Wang and
Mo-Fang Liu and
Jingjing Jiang and
Xihua Li and
Hao Ying Thyroid hormone regulates muscle fiber
type conversion via miR-133a1 . . . . . 753
Emmanuel Dornier and
Franck Coumailleau and
Jean-François Ottavi and
Julien Moretti and
Claude Boucheix and
Philippe Mauduit and
François Schweisguth and
Eric Rubinstein Correction: TspanC8 tetraspanins
regulate ADAM10/Kuzbanian trafficking
and promote Notch activation in flies
and mammals . . . . . . . . . . . . . . 495
William J. Gault and
Balázs Enyedi and
Philipp Niethammer Osmotic surveillance mediates rapid
wound closure through nucleotide release 767
Xiaodong Fang and
Jianying Luo and
Ryuichi Nishihama and
Carsten Wloka and
Christopher Dravis and
Mirko Travaglia and
Masayuki Iwase and
Elizabeth A. Vallen and
Erfei Bi Correction: Biphasic targeting and
cleavage furrow ingression directed by
the tail of a myosin II . . . . . . . . 591