Last update:
Thu Nov 3 12:09:33 MDT 2022
A. Desai and
T. J. Mitchison A new role for motor proteins as
couplers to depolymerizing microtubules 1
U. F. Greber and
L. Gerace Depletion of calcium from the lumen of
endoplasmic reticulum reversibly
inhibits passive diffusion and
signal-mediated transport into the
nucleus . . . . . . . . . . . . . . . . 5
M. A. Garcia-Blanco and
D. D. Miller and
M. P. Sheetz Nuclear spreads: I. Visualization of
bipartite ribosomal RNA domains . . . . 15
P. S. Kim and
P. Arvan Calnexin and BiP act as sequential
molecular chaperones during
thyroglobulin folding in the endoplasmic
reticulum . . . . . . . . . . . . . . . 29
A. Chang and
G. R. Fink Targeting of the yeast plasma membrane
[H+]ATPase: a novel gene AST1 prevents
mislocalization of mutant ATPase to the
vacuole . . . . . . . . . . . . . . . . 39
M. Way and
M. Sanders and
C. Garcia and
J. Sakai and
P. Matsudaira Sequence and domain organization of
scruin, an actin-cross-linking protein
in the acrosomal process of Limulus
sperm . . . . . . . . . . . . . . . . . 51
D. A. Schafer and
C. Hug and
J. A. Cooper Inhibition of CapZ during
myofibrillogenesis alters assembly of
actin filaments . . . . . . . . . . . . 61
H. Deng and
J. K. Lee and
L. S. Goldstein and
D. Branton Drosophila development requires spectrin
network formation . . . . . . . . . . . 71
Y. H. Song and
E. Mandelkow The anatomy of flagellar microtubules:
polarity, seam, junctions, and lattice 81
L. Wordeman and
T. J. Mitchison Identification and partial
characterization of mitotic
centromere-associated kinesin, a
kinesin-related protein that associates
with centromeres during mitosis . . . . 95
V. A. Lombillo and
C. Nislow and
T. J. Yen and
V. I. Gelfand and
J. R. McIntosh Antibodies to the kinesin motor domain
and CENP--E inhibit microtubule
depolymerization-dependent motion of
chromosomes in vitro . . . . . . . . . . 107
A. A. Hyman and
D. Chrétien and
I. Arnal and
R. H. Wade Structural changes accompanying GTP
hydrolysis in microtubules: information
from a slowly hydrolyzable analogue
guanylyl-(alpha,beta)-methylene-diphosphonate 117
E. Tanaka and
M. W. Kirschner The role of microtubules in growth cone
turning at substrate boundaries . . . . 127
E. Tanaka and
T. Ho and
M. W. Kirschner The role of microtubule dynamics in
growth cone motility and axonal growth 139
K. M. Albers and
F. E. Davis and
T. N. Perrone and
E. Y. Lee and
Y. Liu and
M. Vore Expression of an epidermal keratin
protein in liver of transgenic mice
causes structural and functional
abnormalities . . . . . . . . . . . . . 157
A. S. Woolf and
M. Kolatsi-Joannou and
P. Hardman and
E. Andermarcher and
C. Moorby and
L. G. Fine and
P. S. Jat and
M. D. Noble and
E. Gherardi Roles of hepatocyte growth
factor/scatter factor and the met
receptor in the early development of the
metanephros . . . . . . . . . . . . . . 171
T. Timmusk and
U. Lendahl and
H. Funakoshi and
E. Arenas and
H. Persson and
M. Metsis Identification of brain-derived
neurotrophic factor promoter regions
mediating tissue-specific, axotomy-, and
neuronal activity-induced expression in
transgenic mice . . . . . . . . . . . . 185
I. Martinou and
P. A. Fernandez and
M. Missotten and
E. White and
B. Allet and
R. Sadoul and
J. C. Martinou Viral proteins E1B19K and p35 protect
sympathetic neurons from cell death
induced by NGF deprivation . . . . . . . 201
M. K. Byeon and
Y. Sugi and
R. R. Markwald and
S. Hoffman NCAM polypeptides in heart development:
association with Z discs of forms that
contain the muscle-specific domain . . . 209
K. S. Cheah and
A. Levy and
P. A. Trainor and
A. W. Wai and
T. Kuffner and
C. L. So and
K. K. Leung and
R. H. Lovell-Badge and
P. P. Tam Human COL2A1-directed SV40 T antigen
expression in transgenic and chimeric
mice results in abnormal skeletal
development . . . . . . . . . . . . . . 223
V. Lefebvre and
S. Garofalo and
B. de Crombrugghe Type X collagen gene expression in mouse
chondrocytes immortalized by a
temperature-sensitive simian virus 40
large tumor antigen . . . . . . . . . . 239
F. Buss and
M. Stewart Macromolecular interactions in the
nucleoporin p62 complex of rat nuclear
pores: binding of nucleoporin p54 to the
rod domain of p62 . . . . . . . . . . . 251
J. Staudinger and
J. Zhou and
R. Burgess and
S. J. Elledge and
E. N. Olson PICK1: a perinuclear binding protein and
substrate for protein kinase C isolated
by the yeast two-hybrid system . . . . . 263
J. D. Miller and
S. Tajima and
L. Lauffer and
P. Walter The beta subunit of the signal
recognition particle receptor is a
transmembrane GTPase that anchors the
alpha subunit, a peripheral membrane
GTPase, to the endoplasmic reticulum
membrane . . . . . . . . . . . . . . . . 273
B. U. Barth and
J. M. Wahlberg and
H. Garoff The oligomerization reaction of the
Semliki Forest virus membrane protein
subunits . . . . . . . . . . . . . . . . 283
J. Lippincott-Schwartz and
N. B. Cole and
A. Marotta and
P. A. Conrad and
G. S. Bloom Kinesin is the motor for
microtubule-mediated Golgi--to--ER
membrane traffic . . . . . . . . . . . . 293
X. Tan and
H. R. Waterham and
M. Veenhuis and
J. M. Cregg The Hansenula polymorpha PER8 gene
encodes a novel peroxisomal integral
membrane protein involved in
proliferation . . . . . . . . . . . . . 307
S. Höning and
W. Hunziker Cytoplasmic determinants involved in
direct lysosomal sorting, endocytosis,
and basolateral targeting of rat lgp120
(lamp--I) in MDCK cells . . . . . . . . 321
C. F. Lu and
R. C. Montijn and
J. L. Brown and
F. Klis and
J. Kurjan and
H. Bussey and
P. N. Lipke Glycosyl phosphatidylinositol-dependent
cross-linking of alpha-agglutinin and
beta 1,6-glucan in the
\bionameSaccharomyces cerevisiae cell
wall . . . . . . . . . . . . . . . . . . 333
M. Raichman and
M. C. Panzeri and
E. Clementi and
P. Papazafiri and
M. Eckley and
D. O. Clegg and
A. Villa and
J. Meldolesi Differential localization and functional
role of calsequestrin in growing and
differentiated myoblasts . . . . . . . . 341
C. Pasternak and
S. Wong and
E. L. Elson Mechanical function of dystrophin in
muscle cells . . . . . . . . . . . . . . 355
A. H. Ahn and
L. M. Kunkel Syntrophin binds to an alternatively
spliced exon of dystrophin . . . . . . . 363
A. Suzuki and
M. Yoshida and
E. Ozawa Mammalian alpha 1- and beta
$1$-syntrophin bind to the alternative
splice-prone region of the dystrophin
COOH terminus . . . . . . . . . . . . . 373
B. Drees and
C. Brown and
B. G. Barrell and
A. Bretscher Tropomyosin is essential in yeast, yet
the TPM1 and TPM2 products perform
distinct functions . . . . . . . . . . . 383
A. Ayme-Southgate and
R. Southgate and
J. Saide and
G. M. Benian and
M. L. Pardue Both synchronous and asynchronous muscle
isoforms of projectin (the
\bionameDrosophila bent locus product)
contain functional kinase domains . . . 393
J. E. Segall and
A. Kuspa and
G. Shaulsky and
M. Ecke and
M. Maeda and
C. Gaskins and
R. A. Firtel and
W. F. Loomis A MAP kinase necessary for
receptor-mediated activation of adenylyl
cyclase in \bionameDictyostelium . . . . 405
J. S. Zhang and
F. M. Longo LAR tyrosine phosphatase receptor:
alternative splicing is preferential to
the nervous system, coordinated with
cell growth and generates novel isoforms
containing extensive CAG repeats . . . . 415
J. Arribas and
J. Massagué Transforming growth factor-alpha and
beta-amyloid precursor protein share a
secretory mechanism . . . . . . . . . . 433
L. G. Marschall and
L. Clarke A novel cis-acting centromeric DNA
element affects S. pombe centromeric
chromatin structure at a distance . . . 445
M. Sym and
G. S. Roeder Zip1-induced changes in synaptonemal
complex structure and polycomplex
assembly . . . . . . . . . . . . . . . . 455
E. E. Schmidt and
U. Schibler Cell size regulation, a mechanism that
controls cellular RNA accumulation:
consequences on regulation of the
ubiquitous transcription factors Oct1
and NF--Y and the liver-enriched
transcription factor DBP . . . . . . . . 467
R. Fischer and
W. E. Timberlake Aspergillus nidulans apsA (anucleate
primary sterigmata) encodes a
coiled-coil protein required for nuclear
positioning and completion of asexual
development . . . . . . . . . . . . . . 485
R. C. Piper and
X. Xu and
D. G. Russell and
B. M. Little and
S. M. Landfear Differential targeting of two glucose
transporters from Leishmania enriettii
is mediated by an NH2-terminal domain 499
R. Erdmann and
G. Blobel Giant peroxisomes in oleic acid-induced
\bionameSaccharomyces cerevisiae lacking
the peroxisomal membrane protein Pmp27p 509
S. Silberstein and
P. G. Collins and
D. J. Kelleher and
P. J. Rapiejko and
R. Gilmore The alpha subunit of the
\bionameSaccharomyces cerevisiae
oligosaccharyltransferase complex is
essential for vegetative growth of yeast
and is homologous to mammalian
ribophorin I . . . . . . . . . . . . . . 525
C. Haass and
E. H. Koo and
A. Capell and
D. B. Teplow and
D. J. Selkoe Polarized sorting of beta-amyloid
precursor protein and its proteolytic
products in MDCK cells is regulated by
two independent signals . . . . . . . . 537
R. N. Ghosh and
F. R. Maxfield Evidence for nonvectorial, retrograde
transferrin trafficking in the early
endosomes of HEp2 cells . . . . . . . . 549
J. M. Venuti and
J. H. Morris and
J. L. Vivian and
E. N. Olson and
W. H. Klein Myogenin is required for late but not
early aspects of myogenesis during mouse
development . . . . . . . . . . . . . . 563
C. A. McGoldrick and
C. Gruver and
G. S. May myoA of Aspergillus nidulans encodes an
essential myosin I required for
secretion and polarized growth . . . . . 577
S. Muallem and
K. Kwiatkowska and
X. Xu and
H. L. Yin Actin filament disassembly is a
sufficient final trigger for exocytosis
in nonexcitable cells . . . . . . . . . 589
R. Li and
Y. Zheng and
D. G. Drubin Regulation of cortical actin
cytoskeleton assembly during polarized
cell growth in budding yeast . . . . . . 599
W. S. Saunders and
D. Koshland and
D. Eshel and
I. R. Gibbons and
M. A. Hoyt Saccharomyces cerevisiae kinesin- and
dynein-related proteins required for
anaphase chromosome segregation . . . . 617
M. Gesemann and
A. J. Denzer and
M. A. Ruegg Acetylcholine receptor-aggregating
activity of agrin isoforms and mapping
of the active site . . . . . . . . . . . 625
C. Walch-Solimena and
J. Blasi and
L. Edelmann and
E. R. Chapman and
G. F. von Mollard and
R. Jahn The t--SNAREs syntaxin 1 and SNAP-25 are
present on organelles that participate
in synaptic vesicle recycling . . . . . 637
L. Aigner and
P. Caroni Absence of persistent spreading,
branching, and adhesion in
GAP-43-depleted growth cones . . . . . . 647
K. L. Moore and
K. D. Patel and
R. E. Bruehl and
F. Li and
D. A. Johnson and
H. S. Lichenstein and
R. D. Cummings and
D. F. Bainton and
R. P. McEver P-selectin glycoprotein ligand-1
mediates rolling of human neutrophils on
P-selectin . . . . . . . . . . . . . . . 661
D. G. Jackson and
J. I. Bell and
R. Dickinson and
J. Timans and
J. Shields and
N. Whittle Proteoglycan forms of the lymphocyte
homing receptor CD44 are alternatively
spliced variants containing the v3 exon 673
K. L. Bennett and
D. G. Jackson and
J. C. Simon and
E. Tanczos and
R. Peach and
B. Modrell and
I. Stamenkovic and
G. Plowman and
A. Aruffo CD44 isoforms containing exon V3 are
responsible for the presentation of
heparin-binding growth factor . . . . . 687
A. Beauvais and
C. A. Erickson and
T. Goins and
S. E. Craig and
M. J. Humphries and
J. P. Thiery and
S. Dufour Changes in the fibronectin-specific
integrin expression pattern modify the
migratory behavior of sarcoma S180 cells
in vitro and in the embryonic
environment . . . . . . . . . . . . . . 699
M. A. Powers and
C. Macaulay and
F. R. Masiarz and
D. J. Forbes Reconstituted nuclei depleted of a
vertebrate GLFG nuclear pore protein,
p97, import but are defective in nuclear
growth and replication . . . . . . . . . 721
F. Poulat and
F. Girard and
M. P. Chevron and
C. Gozé and
X. Rebillard and
B. Calas and
N. Lamb and
P. Berta Nuclear localization of the testis
determining gene product SRY . . . . . . 737
A. V. Strunnikov and
J. Kingsbury and
D. Koshland CEP3 encodes a centromere protein of
\bionameSaccharomyces cerevisiae . . . . 749
S. Z. Wang and
R. Adler Chromokinesin: a DNA-binding,
kinesin-like nuclear protein . . . . . . 761
D. A. Shaywitz and
L. Orci and
M. Ravazzola and
A. Swaroop and
C. A. Kaiser Human SEC13Rp functions in yeast and is
located on transport vesicles budding
from the endoplasmic reticulum . . . . . 769
T. A. Vida and
S. D. Emr A new vital stain for visualizing
vacuolar membrane dynamics and
endocytosis in yeast . . . . . . . . . . 779
K. Hanada and
R. E. Pagano A Chinese hamster ovary cell mutant
defective in the non-endocytic uptake of
fluorescent analogs of
phosphatidylserine: isolation using a
cytosol acidification protocol . . . . . 793
A. Shartava and
C. A. Monteiro and
F. A. Bencsath and
K. Schneider and
B. T. Chait and
R. Gussio and
L. A. Casoria-Scott and
A. K. Shah and
C. A. Heuerman and
S. R. Goodman A posttranslational modification of
beta-actin contributes to the slow
dissociation of the spectrin-protein
4.1-actin complex of irreversibly
sickled cells . . . . . . . . . . . . . 805
D. Cox and
J. A. Ridsdale and
J. Condeelis and
J. Hartwig Genetic deletion of ABP-120 alters the
three-dimensional organization of actin
filaments in \bionameDictyostelium
pseudopods . . . . . . . . . . . . . . . 819
C. B. Shuster and
I. M. Herman Indirect association of ezrin with
F-actin: isoform specificity and calcium
sensitivity . . . . . . . . . . . . . . 837
K. Ookata and
S. Hisanaga and
J. C. Bulinski and
H. Murofushi and
H. Aizawa and
T. J. Itoh and
H. Hotani and
E. Okumura and
K. Tachibana and
T. Kishimoto Cyclin B interaction with
microtubule-associated protein 4 (MAP4)
targets p34cdc2 kinase to microtubules
and is a potential regulator of M-phase
microtubule dynamics . . . . . . . . . . 849
A. Spang and
I. Courtney and
K. Grein and
M. Matzner and
E. Schiebel The Cdc31p-binding protein Kar1p is a
component of the half bridge of the
yeast spindle pole body . . . . . . . . 863
V. Allan Protein phosphatase 1 regulates the
cytoplasmic dynein-driven formation of
endoplasmic reticulum networks in vitro 879
G. Giannini and
A. Conti and
S. Mammarella and
M. Scrobogna and
V. Sorrentino The ryanodine receptor/calcium channel
genes are widely and differentially
expressed in murine brain and peripheral
tissues . . . . . . . . . . . . . . . . 893
P. E. Ceccaldi and
F. Grohovaz and
F. Benfenati and
E. Chieregatti and
P. Greengard and
F. Valtorta Dephosphorylated synapsin I anchors
synaptic vesicles to actin cytoskeleton:
an analysis by videomicroscopy . . . . . 905
E. Posse de Chaves and
D. E. Vance and
R. B. Campenot and
J. E. Vance Axonal synthesis of phosphatidylcholine
is required for normal axonal growth in
rat sympathetic neurons . . . . . . . . 913
B. Allinquant and
P. Hantraye and
P. Mailleux and
K. Moya and
C. Bouillot and
A. Prochiantz Downregulation of amyloid precursor
protein inhibits neurite outgrowth in
vitro . . . . . . . . . . . . . . . . . 919
S. Higashiyama and
R. Iwamoto and
K. Goishi and
G. Raab and
N. Taniguchi and
M. Klagsbrun and
E. Mekada The membrane protein CD9/DRAP 27
potentiates the juxtacrine growth factor
activity of the membrane-anchored
heparin-binding EGF-like growth factor 929
J. Y. Roh and
J. R. Stanley Intracellular domain of desmoglein 3
(pemphigus vulgaris antigen) confers
adhesive function on the extracellular
domain of E-cadherin without binding
catenins . . . . . . . . . . . . . . . . 939
S. Shibamoto and
M. Hayakawa and
K. Takeuchi and
T. Hori and
K. Miyazawa and
N. Kitamura and
K. R. Johnson and
M. J. Wheelock and
N. Matsuyoshi and
M. Takeichi Association of p120, a tyrosine kinase
substrate, with E-cadherin/catenin
complexes . . . . . . . . . . . . . . . 949
N. Funayama and
F. Fagotto and
P. McCrea and
B. M. Gumbiner Embryonic axis induction by the
armadillo repeat domain of beta-catenin:
evidence for intracellular signaling . . 959
S. Pfau and
D. Leitenberg and
H. Rinder and
B. R. Smith and
R. Pardi and
J. R. Bender Lymphocyte adhesion-dependent calcium
signaling in human endothelial cells . . 969
R. Fässler and
M. Pfaff and
J. Murphy and
A. A. Noegel and
S. Johansson and
R. Timpl and
R. Albrecht Lack of beta 1 integrin gene in
embryonic stem cells affects morphology,
adhesion, and migration but not
integration into the inner cell mass of
blastocysts . . . . . . . . . . . . . . 979
K. L. Taneja and
M. McCurrach and
M. Schalling and
D. Housman and
R. H. Singer Foci of trinucleotide repeat transcripts
in nuclei of myotonic dystrophy cells
and tissues . . . . . . . . . . . . . . 995
P. J. Peters and
V. W. Hsu and
C. E. Ooi and
D. Finazzi and
S. B. Teal and
V. Oorschot and
J. G. Donaldson and
R. D. Klausner Overexpression of wild-type and mutant
ARF1 and ARF6: distinct perturbations of
nonoverlapping membrane compartments . . 1003
K. Sadoul and
J. Lang and
C. Montecucco and
U. Weller and
R. Regazzi and
S. Catsicas and
C. B. Wollheim and
P. A. Halban SNAP-25 is expressed in islets of
Langerhans and is involved in insulin
release . . . . . . . . . . . . . . . . 1019
B. F. Roettger and
R. U. Rentsch and
D. Pinon and
E. Holicky and
E. Hadac and
J. M. Larkin and
L. J. Miller Dual pathways of internalization of the
cholecystokinin receptor . . . . . . . . 1029
K. Fiedler and
F. Lafont and
R. G. Parton and
K. Simons Annexin XIIIb: a novel epithelial
specific annexin is implicated in
vesicular traffic to the apical plasma
membrane . . . . . . . . . . . . . . . . 1043
B. Govindan and
R. Bowser and
P. Novick The role of Myo2, a yeast class V
myosin, in vesicular transport . . . . . 1055
R. J. Hu and
S. Moorthy and
V. Bennett Expression of functional domains of beta
G-spectrin disrupts epithelial
morphology in cultured cells . . . . . . 1069
M. Martin and
C. Andréoli and
A. Sahuquet and
P. Montcourrier and
M. Algrain and
P. Mangeat Ezrin NH2-terminal domain inhibits the
cell extension activity of the
COOH-terminal domain . . . . . . . . . . 1081
J. Z. Chuang and
D. C. Lin and
S. Lin Molecular cloning, expression, and
mapping of the high affinity
actin-capping domain of chicken cardiac
tensin . . . . . . . . . . . . . . . . . 1095
C. Rosette and
M. Karin Cytoskeletal control of gene expression:
depolymerization of microtubules
activates NF-kappa B . . . . . . . . . . 1111
B. G. Wallace Regulation of the interaction of
nicotinic acetylcholine receptors with
the cytoskeleton by agrin-activated
protein tyrosine kinase . . . . . . . . 1121
E. Sontag and
V. Nunbhakdi-Craig and
G. S. Bloom and
M. C. Mumby A novel pool of protein phosphatase 2A
is associated with microtubules and is
regulated during the cell cycle . . . . 1131
J. E. Turner and
C. G. Minkoff and
K. H. Martin and
R. Misra and
K. I. Swenson Oocyte activation and passage through
the metaphase/anaphase transition of the
meiotic cell cycle is blocked in clams
by inhibitors of HMG--CoA reductase
activity . . . . . . . . . . . . . . . . 1145
D. R. Robinson and
T. Sherwin and
A. Ploubidou and
E. H. Byard and
K. Gull Microtubule polarity and dynamics in the
control of organelle positioning,
segregation, and cytokinesis in the
trypanosome cell cycle . . . . . . . . . 1163
T. Yang and
K. M. Kozopas and
R. W. Craig The intracellular distribution and
pattern of expression of Mcl-1 overlap
with, but are not identical to, those of
Bcl-2 . . . . . . . . . . . . . . . . . 1173
G. R. Merlo and
F. Basolo and
L. Fiore and
L. Duboc and
N. E. Hynes p53-dependent and p53-independent
activation of apoptosis in mammary
epithelial cells reveals a survival
function of EGF and insulin . . . . . . 1185
I. Västrik and
A. Kaipainen and
T. L. Penttilä and
A. Lymboussakis and
R. Alitalo and
M. Parvinen and
K. Alitalo Expression of the mad gene during cell
differentiation in vivo and its
inhibition of cell growth in vitro . . . 1197
N. A. Hotchin and
A. Gandarillas and
F. M. Watt Regulation of cell surface beta 1
integrin levels during keratinocyte
terminal differentiation . . . . . . . . 1209
A. Hanneken and
P. A. Maher and
A. Baird High affinity immunoreactive FGF
receptors in the extracellular matrix of
vascular endothelial cells--implications
for the modulation of FGF-2 . . . . . . 1221
J. Fawcett and
C. Buckley and
C. L. Holness and
I. N. Bird and
J. H. Spragg and
J. Saunders and
A. Harris and
D. L. Simmons Mapping the homotypic binding sites in
CD31 and the role of CD31 adhesion in
the formation of interendothelial cell
contacts . . . . . . . . . . . . . . . . 1229
R. Alon and
P. D. Kassner and
M. W. Carr and
E. B. Finger and
M. E. Hemler and
T. A. Springer The integrin VLA-4 supports tethering
and rolling in flow on VCAM-1 . . . . . 1243
H. Yan and
J. Newport An analysis of the regulation of DNA
synthesis by cdk2, Cip1, and licensing
factor . . . . . . . . . . . . . . . . . 1
I. Firmbach-Kraft and
R. Stick Analysis of nuclear lamin isoprenylation
in \bionameXenopus oocytes:
isoprenylation of lamin B3 precedes its
uptake into the nucleus . . . . . . . . 17
S. Gratzer and
T. Lithgow and
R. E. Bauer and
E. Lamping and
F. Paltauf and
S. D. Kohlwein and
V. Haucke and
T. Junne and
G. Schatz and
M. Horst Mas37p, a novel receptor subunit for
protein import into mitochondria . . . . 25
S. F. Nothwehr and
E. Conibear and
T. H. Stevens Golgi and vacuolar membrane proteins
reach the vacuole in vps1 mutant yeast
cells via the plasma membrane . . . . . 35
C. Lamaze and
S. L. Schmid Recruitment of epidermal growth factor
receptors into coated pits requires
their activated tyrosine kinase . . . . 47
A. Hémar and
A. Subtil and
M. Lieb and
E. Morelon and
R. Hellio and
A. Dautry-Varsat Endocytosis of interleukin 2 receptors
in human T lymphocytes: distinct
intracellular localization and fate of
the receptor alpha, beta, and gamma
chains . . . . . . . . . . . . . . . . . 55
J. W. Zhang and
P. B. Lazarow PEB1 (PAS7) in \bionameSaccharomyces
cerevisiae encodes a hydrophilic,
intra-peroxisomal protein that is a
member of the WD repeat family and is
essential for the import of thiolase
into peroxisomes . . . . . . . . . . . . 65
F. Garcia-del Portillo and
B. B. Finlay Targeting of Salmonella typhimurium to
vesicles containing lysosomal membrane
glycoproteins bypasses compartments with
mannose $6$-phosphate receptors . . . . 81
K. Lollike and
N. Borregaard and
M. Lindau The exocytotic fusion pore of small
granules has a conductance similar to an
ion channel . . . . . . . . . . . . . . 99
E. P. Garcia and
P. S. McPherson and
T. J. Chilcote and
K. Takei and
P. De Camilli rbSec1A and B colocalize with syntaxin 1
and SNAP-25 throughout the axon, but are
not in a stable complex with syntaxin 105
A. Taraboulos and
M. Scott and
A. Semenov and
D. Avrahami and
L. Laszlo and
S. B. Prusiner and
D. Avraham Cholesterol depletion and modification
of COOH-terminal targeting sequence of
the prion protein inhibit formation of
the scrapie isoform . . . . . . . . . . 121
H. S. Kruth and
S. I. Skarlatos and
K. Lilly and
J. Chang and
I. Ifrim Sequestration of acetylated LDL and
cholesterol crystals by human
monocyte-derived macrophages . . . . . . 133
H. Q. Sun and
K. Kwiatkowska and
D. C. Wooten and
H. L. Yin Effects of CapG overexpression on
agonist-induced motility and second
messenger generation . . . . . . . . . . 147
Y. Noda and
R. Sato-Yoshitake and
S. Kondo and
M. Nangaku and
N. Hirokawa KIF2 is a new microtubule-based
anterograde motor that transports
membranous organelles distinct from
those carried by kinesin heavy chain or
KIF3A/B . . . . . . . . . . . . . . . . 157
C. G. Wilkerson and
S. M. King and
A. Koutoulis and
G. J. Pazour and
G. B. Witman The 78,000 M(r) intermediate chain of
Chlamydomonas outer arm dynein isa
WD-repeat protein required for arm
assembly . . . . . . . . . . . . . . . . 169
M. Kreitmeier and
G. Gerisch and
C. Heizer and
A. Müller-Taubenberger A talin homologue of
\bionameDictyostelium rapidly assembles
at the leading edge of cells in response
to chemoattractant . . . . . . . . . . . 179
A. M. Fannon and
D. L. Sherman and
G. Ilyina-Gragerova and
P. J. Brophy and
V. L. Friedrich and
D. R. Colman Novel E-cadherin-mediated adhesion in
peripheral nerve: Schwann cell
architecture is stabilized by autotypic
adherens junctions . . . . . . . . . . . 189
M. G. Lampugnani and
M. Corada and
L. Caveda and
F. Breviario and
O. Ayalon and
B. Geiger and
E. Dejana The molecular organization of
endothelial cell to cell junctions:
differential association of plakoglobin,
beta-catenin, and alpha-catenin with
vascular endothelial cadherin
(VE-cadherin) . . . . . . . . . . . . . 203
T. J. Chilcote and
T. Galli and
O. Mundigl and
L. Edelmann and
P. S. McPherson and
K. Takei and
P. De Camilli Cellubrevin and synaptobrevins: similar
subcellular localization and biochemical
properties in PC12 cells . . . . . . . . 219
A. Bikfalvi and
S. Klein and
G. Pintucci and
N. Quarto and
P. Mignatti and
D. B. Rifkin Differential modulation of cell
phenotype by different molecular weight
forms of basic fibroblast growth factor:
possible intracellular signaling by the
high molecular weight forms . . . . . . 233
H. A. Franch and
J. W. Shay and
R. J. Alpern and
P. A. Preisig Involvement of pRB family in TGF
beta-dependent epithelial cell
hypertrophy . . . . . . . . . . . . . . 245
J. Wesseling and
S. W. van der Valk and
H. L. Vos and
A. Sonnenberg and
J. Hilkens Episialin (MUC1) overexpression inhibits
integrin-mediated cell adhesion to
extracellular matrix components . . . . 255
T. A. Mitsiadis and
T. Muramatsu and
H. Muramatsu and
I. Thesleff Midkine (MK), a heparin-binding
growth/differentiation factor, is
regulated by retinoic acid and
epithelial-mesenchymal interactions in
the developing mouse tooth, and affects
cell proliferation and morphogenesis . . 267
D. B. Bregman and
L. Du and
S. van der Zee and
S. L. Warren Transcription-dependent redistribution
of the large subunit of RNA polymerase
II to discrete nuclear domains . . . . . 287
S. Reinbothe and
C. Reinbothe and
S. Runge and
K. Apel Enzymatic product formation impairs both
the chloroplast receptor-binding
function as well as translocation
competence of the NADPH:
protochlorophyllide oxidoreductase, a
nuclear-encoded plastid precursor
protein . . . . . . . . . . . . . . . . 299
G. Miesenböck and
J. E. Rothman The capacity to retrieve escaped ER
proteins extends to the trans-most
cisterna of the Golgi stack . . . . . . 309
J. H. Stack and
D. B. DeWald and
K. Takegawa and
S. D. Emr Vesicle-mediated protein transport:
regulatory interactions between the
Vps15 protein kinase and the Vps34
PtdIns $3$-kinase essential for protein
sorting to the vacuole in yeast . . . . 321
A. Stahl and
B. M. Mueller The urokinase-type plasminogen activator
receptor, a GPI-linked protein, is
localized in caveolae . . . . . . . . . 335
P. A. Marshall and
Y. I. Krimkevich and
R. H. Lark and
J. M. Dyer and
M. Veenhuis and
J. M. Goodman Pmp27 promotes peroxisomal proliferation 345
W. J. LaRochelle and
O. R. Dirsch and
P. W. Finch and
H. G. Cheon and
M. May and
C. Marchese and
J. H. Pierce and
S. A. Aaronson Specific receptor detection by a
functional keratinocyte growth
factor-immunoglobulin chimera . . . . . 357
T. Adam and
M. Arpin and
M. C. Prévost and
P. Gounon and
P. J. Sansonetti Cytoskeletal rearrangements and the
functional role of T-plastin during
entry of Shigella flexneri into HeLa
cells . . . . . . . . . . . . . . . . . 367
R. Kelly and
S. Alonso and
S. Tajbakhsh and
G. Cossu and
M. Buckingham Myosin light chain 3F regulatory
sequences confer regionalized cardiac
and skeletal muscle expression in
transgenic mice . . . . . . . . . . . . 383
P. Turowski and
A. Fernandez and
B. Favre and
N. J. Lamb and
B. A. Hemmings Differential methylation and altered
conformation of cytoplasmic and nuclear
forms of protein phosphatase 2A during
cell cycle progression . . . . . . . . . 397
T. Nakagawa and
J. Chen and
Z. Zhang and
Y. Kanai and
N. Hirokawa Two distinct functions of the
carboxyl-terminal tail domain of NF--M
upon neurofilament assembly:
cross-bridge formation and longitudinal
elongation of filaments . . . . . . . . 411
T. Yamazaki and
D. J. Selkoe and
E. H. Koo Trafficking of cell surface beta-amyloid
precursor protein: retrograde and
transcytotic transport in cultured
neurons . . . . . . . . . . . . . . . . 431
S. Einheber and
M. J. Hannocks and
C. N. Metz and
D. B. Rifkin and
J. L. Salzer Transforming growth factor-beta 1
regulates axon/Schwann cell interactions 443
N. Benlimame and
D. Simard and
I. R. Nabi Autocrine motility factor receptor is a
marker for a distinct membranous tubular
organelle . . . . . . . . . . . . . . . 459
L. Spinardi and
S. Einheber and
T. Cullen and
T. A. Milner and
F. G. Giancotti A recombinant tail-less integrin beta 4
subunit disrupts hemidesmosomes, but
does not suppress alpha 6 beta
$4$-mediated cell adhesion to laminins 473
M. L. Hermiston and
J. I. Gordon In vivo analysis of cadherin function in
the mouse intestinal epithelium:
essential roles in adhesion, maintenance
of differentiation, and regulation of
programmed cell death . . . . . . . . . 489
J. A. Marrs and
C. Andersson-Fisone and
M. C. Jeong and
L. Cohen-Gould and
C. Zurzolo and
I. R. Nabi and
E. Rodriguez-Boulan and
W. J. Nelson Plasticity in epithelial cell phenotype:
modulation by expression of different
cadherin cell adhesion molecules . . . . 507
Y. Kadoya and
K. Kadoya and
M. Durbeej and
K. Holmvall and
L. Sorokin and
P. Ekblom Antibodies against domain E3 of
laminin-1 and integrin alpha 6 subunit
perturb branching epithelial
morphogenesis of submandibular gland,
but by different modes . . . . . . . . . 521
R. Killick and
P. K. Legan and
C. Malenczak and
G. P. Richardson Molecular cloning of chick
beta-tectorin, an extracellular matrix
molecule of the inner ear . . . . . . . 535
H. Siomi and
G. Dreyfuss A nuclear localization domain in the
hnRNP A1 protein . . . . . . . . . . . . 551
D. Weisenberger and
U. Scheer A possible mechanism for the inhibition
of ribosomal RNA gene transcription
during mitosis . . . . . . . . . . . . . 561
U. Acharya and
J. M. McCaffery and
R. Jacobs and
V. Malhotra Reconstitution of vesiculated Golgi
membranes into stacks of cisternae:
requirement of NSF in stack formation 577
C. H. Streuli and
C. Schmidhauser and
N. Bailey and
P. Yurchenco and
A. P. Skubitz and
C. Roskelley and
M. J. Bissell Laminin mediates tissue-specific gene
expression in mammary epithelia . . . . 591
C. Rabouille and
T. Misteli and
R. Watson and
G. Warren Reassembly of Golgi stacks from mitotic
Golgi fragments in a cell-free system 605
A. Gorodinsky and
D. A. Harris Glycolipid-anchored proteins in
neuroblastoma cells form
detergent-resistant complexes without
caveolin . . . . . . . . . . . . . . . . 619
D. Hamburger and
M. Egerton and
H. Riezman Yeast Gaa1p is required for attachment
of a completed GPI anchor onto proteins 629
P. M. Haney and
M. A. Levy and
M. S. Strube and
M. Mueckler Insulin-sensitive targeting of the GLUT4
glucose transporter in L6 myoblasts is
conferred by its COOH-terminal
cytoplasmic tail . . . . . . . . . . . . 641
X. H. Sun and
F. Protasi and
M. Takahashi and
H. Takeshima and
D. G. Ferguson and
C. Franzini-Armstrong Molecular architecture of membranes
involved in excitation-contraction
coupling of cardiac muscle . . . . . . . 659
S. L. Carl and
K. Felix and
A. H. Caswell and
N. R. Brandt and
W. J. Ball and
P. L. Vaghy and
G. Meissner and
D. G. Ferguson Immunolocalization of sarcolemmal
dihydropyridine receptor and
sarcoplasmic reticular triadin and
ryanodine receptor in rabbit ventricle
and atrium . . . . . . . . . . . . . . . 673
C. C. Gregorio and
V. M. Fowler Mechanisms of thin filament assembly in
embryonic chick cardiac myocytes:
tropomodulin requires tropomyosin for
assembly . . . . . . . . . . . . . . . . 683
K. S. Warren and
J. L. Lin and
J. P. McDermott and
J. J. Lin Forced expression of chimeric human
fibroblast tropomyosin mutants affects
cytokinesis . . . . . . . . . . . . . . 697
B. C. Williams and
M. F. Riedy and
E. V. Williams and
M. Gatti and
M. L. Goldberg The \bionameDrosophila kinesin-like
protein KLP3A is a midbody component
required for central spindle assembly
and initiation of cytokinesis . . . . . 709
I. A. Dawson and
S. Roth and
S. Artavanis-Tsakonas The \bionameDrosophila cell cycle gene
fizzy is required for normal degradation
of cyclins A and B during mitosis and
has homology to the CDC20 gene of
\bionameSaccharomyces cerevisiae . . . . 725
D. J. Lew and
S. I. Reed A cell cycle checkpoint monitors cell
morphogenesis in budding yeast . . . . . 739
J. Chant and
J. R. Pringle Patterns of bud-site selection in the
yeast \bionameSaccharomyces cerevisiae 751
J. Chant and
M. Mischke and
E. Mitchell and
I. Herskowitz and
J. R. Pringle Role of Bud3p in producing the axial
budding pattern of yeast . . . . . . . . 767
R. S. Slack and
I. S. Skerjanc and
B. Lach and
J. Craig and
K. Jardine and
M. W. McBurney Cells differentiating into neuroectoderm
undergo apoptosis in the absence of
functional retinoblastoma family
proteins . . . . . . . . . . . . . . . . 779
L. Cheng and
M. Khan and
A. W. Mudge Calcitonin gene-related peptide promotes
Schwann cell proliferation . . . . . . . 789
P. Lorenzon and
D. Zacchetti and
F. Codazzi and
G. Fumagalli and
J. Meldolesi and
F. Grohovaz Ca$^{2+}$ waves in PC12 neurites: a
bidirectional, receptor-oriented form of
Ca$^{2+}$ signaling . . . . . . . . . . 797
C. Elfgang and
R. Eckert and
H. Lichtenberg-Fraté and
A. Butterweck and
O. Traub and
R. A. Klein and
D. F. Hülser and
K. Willecke Specific permeability and selective
formation of gap junction channels in
connexin-transfected HeLa cells . . . . 805
H. E. Stöffler and
C. Ruppert and
J. Reinhard and
M. Bähler A novel mammalian myosin I from rat with
an SH3 domain localizes to Con
A-inducible, F-actin-rich structures at
cell--cell contacts . . . . . . . . . . 819
C. Guinebault and
B. Payrastre and
C. Racaud-Sultan and
H. Mazarguil and
M. Breton and
G. Mauco and
M. Plantavid and
H. Chap Integrin-dependent translocation of
phosphoinositide $3$-kinase to the
cytoskeleton of thrombin-activated
platelets involves specific interactions
of p85 alpha with actin filaments and
focal adhesion kinase . . . . . . . . . 831
J. Zheng and
O. Saksela and
S. Matikainen and
A. Vaheri Keratinocyte growth factor is a
bifunctional regulator of HPV16
DNA-immortalized cervical epithelial
cells . . . . . . . . . . . . . . . . . 843
G. Zambruno and
P. C. Marchisio and
A. Marconi and
C. Vaschieri and
A. Melchiori and
A. Giannetti and
M. De Luca Transforming growth factor-beta 1
modulates beta 1 and beta 5 integrin
receptors and induces the de novo
expression of the alpha v beta 6
heterodimer in normal human
keratinocytes: implications for wound
healing . . . . . . . . . . . . . . . . 853
P. Huhtala and
M. J. Humphries and
J. B. McCarthy and
P. M. Tremble and
Z. Werb and
C. H. Damsky Cooperative signaling by alpha 5 beta 1
and alpha 4 beta 1 integrins regulates
metalloproteinase gene expression in
fibroblasts adhering to fibronectin . . 867
D. Aeschlimann and
O. Kaupp and
M. Paulsson Transglutaminase-catalyzed matrix
cross-linking in differentiating
cartilage: identification of osteonectin
as a major glutaminyl substrate . . . . 881
T. Mustonen and
K. Alitalo Endothelial receptor tyrosine kinases
involved in angiogenesis . . . . . . . . 895
K. M. Neugebauer and
J. A. Stolk and
M. B. Roth A conserved epitope on a subset of SR
proteins defines a larger family of
Pre-mRNA splicing factors . . . . . . . 899
M. Cockell and
F. Palladino and
T. Laroche and
G. Kyrion and
C. Liu and
A. J. Lustig and
S. M. Gasser The carboxy termini of Sir4 and Rap1
affect Sir3 localization: evidence for a
multicomponent complex required for
yeast telomeric silencing . . . . . . . 909
B. M. Paschal and
L. Gerace Identification of NTF2, a cytosolic
factor for nuclear import that interacts
with nuclear pore complex protein p62 925
L. C. Gorsch and
T. C. Dockendorff and
C. N. Cole A conditional allele of the novel
repeat-containing yeast nucleoporin
RAT7/NUP159 causes both rapid cessation
of mRNA export and reversible clustering
of nuclear pore complexes . . . . . . . 939
C. V. Nicchitta and
E. C. Murphy and
R. Haynes and
G. S. Shelness Stage- and ribosome-specific alterations
in nascent chain--Sec61p interactions
accompany translocation across the ER
membrane . . . . . . . . . . . . . . . . 957
F. Letourneur and
S. Hennecke and
C. Démolli\`ere and
P. Cosson Steric masking of a dilysine endoplasmic
reticulum retention motif during
assembly of the human high affinity
receptor for immunoglobulin E . . . . . 971
G. Schlenstedt and
S. Harris and
B. Risse and
R. Lill and
P. A. Silver A yeast DnaJ homologue, Scj1p, can
function in the endoplasmic reticulum
with BiP/Kar2p via a conserved domain
that specifies interactions with Hsp70s 979
E. P. Berthiaume and
C. Medina and
J. A. Swanson Molecular size-fractionation during
endocytosis in macrophages . . . . . . . 989
K. V. Kandror and
J. M. Stephens and
P. F. Pilch Expression and compartmentalization of
caveolin in adipose cells: coordinate
regulation with and structural
segregation from GLUT4 . . . . . . . . . 999
M. D. Henry and
C. Gonzalez Agosti and
F. Solomon Molecular dissection of radixin:
distinct and interdependent functions of
the amino- and carboxy-terminal domains 1007
J. M. Schumacher and
K. Lee and
S. Edelhoff and
R. E. Braun Spnr, a murine RNA-binding protein that
is localized to cytoplasmic microtubules 1023
I. Hagan and
M. Yanagida The product of the spindle formation
gene sad1+ associates with the fission
yeast spindle pole body and is essential
for viability . . . . . . . . . . . . . 1033
R. Kuriyama and
M. Kofron and
R. Essner and
T. Kato and
S. Dragas-Granoic and
C. K. Omoto and
A. Khodjakov Characterization of a minus end-directed
kinesin-like motor protein from cultured
mammalian cells . . . . . . . . . . . . 1049
K. Goto and
C. H. Johnson Is the cell division cycle gated by a
circadian clock? The case of
Chlamydomonas reinhardtii . . . . . . . 1061
B. Goldstein Cell contacts orient some cell division
axes in the \bionameCaenorhabditis
elegans embryo . . . . . . . . . . . . . 1071
A. J. Otsuka and
R. Franco and
B. Yang and
K. H. Shim and
L. Z. Tang and
Y. Y. Zhang and
P. Boontrakulpoontawee and
A. Jeyaprakash and
E. Hedgecock and
V. I. Wheaton An ankyrin-related gene (unc-44) is
necessary for proper axonal guidance in
\bionameCaenorhabditis elegans . . . . . 1081
M. W. Cohen and
C. Jacobson and
E. W. Godfrey and
K. P. Campbell and
S. Carbonetto Distribution of alpha-dystroglycan
during embryonic nerve-muscle
synaptogenesis . . . . . . . . . . . . . 1093
H. G. Wang and
J. A. Millan and
A. D. Cox and
C. J. Der and
U. R. Rapp and
T. Beck and
H. Zha and
J. C. Reed R-Ras promotes apoptosis caused by
growth factor deprivation via a Bcl-2
suppressible mechanism . . . . . . . . . 1103
C. Q. Lin and
P. J. Dempsey and
R. J. Coffey and
M. J. Bissell Extracellular matrix regulates whey
acidic protein gene expression by
suppression of TGF-alpha in mouse
mammary epithelial cells: studies in
culture and in transgenic mice . . . . . 1115
S. N. Gettner and
C. Kenyon and
L. F. Reichardt Characterization of beta pat-3
heterodimers, a family of essential
integrin receptors in \bionameC. elegans 1127
R. Li and
J. Xie and
C. Kantor and
V. Koistinen and
D. C. Altieri and
P. Nortamo and
C. G. Gahmberg A peptide derived from the intercellular
adhesion molecule-2 regulates the
avidity of the leukocyte integrins
CD11b/CD18 and CD11c/CD18 . . . . . . . 1143
F. M. Pavalko and
D. M. Walker and
L. Graham and
M. Goheen and
C. M. Doerschuk and
G. S. Kansas The cytoplasmic domain of L-selectin
interacts with cytoskeletal proteins via
alpha-actinin: receptor positioning in
microvilli does not require interaction
with alpha-actinin . . . . . . . . . . . 1155
H. Zhang and
W. Hu and
F. Ramirez Developmental expression of fibrillin
genes suggests heterogeneity of
extracellular microfibrils . . . . . . . 1165
R. Zarnegar and
G. K. Michalopoulos The many faces of hepatocyte growth
factor: from hepatopoiesis to
hematopoiesis . . . . . . . . . . . . . 1177
A. G. Matera and
M. R. Frey and
K. Margelot and
S. L. Wolin A perinucleolar compartment contains
several RNA polymerase III transcripts
as well as the polypyrimidine
tract-binding protein, hnRNP I . . . . . 1181
M. S. Campbell and
G. J. Gorbsky Microinjection of mitotic cells with the
3F3/2 anti-phosphoepitope antibody
delays the onset of anaphase . . . . . . 1195
H. Mehlin and
B. Daneholt and
U. Skoglund Structural interaction between the
nuclear pore complex and a specific
translocating RNP particle . . . . . . . 1205
L. S. Arneson and
J. Miller Efficient endosomal localization of
major histocompatibility complex class
II-invariant chain complexes requires
multimerization of the invariant chain
targeting sequence . . . . . . . . . . . 1217
D. M. Ward and
C. M. Perou and
M. Lloyd and
J. Kaplan ''Synchronized'' endocytosis and
intracellular sorting in alveolar
macrophages: the early sorting endosome
is a transient organelle . . . . . . . . 1229
H. Y. Naim and
D. T. Dodds and
C. B. Brewer and
M. G. Roth Apical and basolateral coated pits of
MDCK cells differ in their rates of
maturation into coated vesicles, but not
in the ability to distinguish between
mutant hemagglutinin proteins with
different internalization signals . . . 1241
I. S. Yuen and
R. Jain and
J. D. Bishop and
D. F. Lindsey and
W. J. Deery and
P. J. Van Haastert and
R. H. Gomer A density-sensing factor regulates
signal transduction in
\bionameDictyostelium . . . . . . . . . 1251
A. Rodríguez and
M. G. Rioult and
A. Ora and
N. W. Andrews A trypanosome-soluble factor induces IP3
formation, intracellular Ca$^{2+}$
mobilization and microfilament
rearrangement in host cells . . . . . . 1263
J. V. Small and
M. Herzog and
K. Anderson Actin filament organization in the fish
keratocyte lamellipodium . . . . . . . . 1275
D. Zhang and
R. B. Nicklas The impact of chromosomes and
centrosomes on spindle assembly as
observed in living cells . . . . . . . . 1287
J. Gaertig and
M. A. Cruz and
J. Bowen and
L. Gu and
D. G. Pennock and
M. A. Gorovsky Acetylation of lysine 40 in
alpha-tubulin is not essential in
\bionameTetrahymena thermophila . . . . 1301
D. Chrétien and
S. D. Fuller and
E. Karsenti Structure of growing microtubule ends:
two-dimensional sheets close into tubes
at variable rates . . . . . . . . . . . 1311
C. Lloyd and
Q. C. Yu and
J. Cheng and
K. Turksen and
L. Degenstein and
E. Hutton and
E. Fuchs The basal keratin network of stratified
squamous epithelia: defining K15
function in the absence of K14 . . . . . 1329
Y. Xiao and
U. Grieshammer and
N. Rosenthal Regulation of a muscle-specific
transgene by retinoic acid . . . . . . . 1345
K. K. Briggs and
A. J. Silvers and
K. M. Johansen and
J. Johansen Calsensin: a novel calcium-binding
protein expressed in a subset of
peripheral leech neurons fasciculating
in a single axon tract . . . . . . . . . 1355
P. J. Lu and
Q. L. Lu and
A. Rughetti and
J. Taylor-Papadimitriou bcl-2 overexpression inhibits cell death
and promotes the morphogenesis, but not
tumorigenesis of human mammary
epithelial cells . . . . . . . . . . . . 1363
C. Murphy-Erdosh and
C. K. Yoshida and
N. Paradies and
L. F. Reichardt The cadherin-binding specificities of
B-cadherin and LCAM . . . . . . . . . . 1379
J. Balsamo and
H. Ernst and
M. K. Zanin and
S. Hoffman and
J. Lilien The interaction of the retina cell
surface
N-acetylgalactosaminylphosphotransferase
with an endogenous proteoglycan ligand
results in inhibition of
cadherin-mediated adhesion . . . . . . . 1391
S. Godyna and
G. Liau and
I. Popa and
S. Stefansson and
W. S. Argraves Identification of the low density
lipoprotein receptor-related protein
(LRP) as an endocytic receptor for
thrombospondin-1 . . . . . . . . . . . . 1403
T. Takebayashi and
M. Iwamoto and
A. Jikko and
T. Matsumura and
M. Enomoto-Iwamoto and
F. Myoukai and
E. Koyama and
T. Yamaai and
K. Matsumoto and
T. Nakamura Hepatocyte growth factor/scatter factor
modulates cell motility, proliferation,
and proteoglycan synthesis of
chondrocytes . . . . . . . . . . . . . . 1411
J. Rossert and
H. Eberspaecher and
B. de Crombrugghe Separate cis-acting DNA elements of the
mouse pro-alpha 1(I) collagen promoter
direct expression of reporter genes to
different type I collagen-producing
cells in transgenic mice . . . . . . . . 1421
I. T. Todorov and
A. Attaran and
S. E. Kearsey BM28, a human member of the MCM2-3-5
family, is displaced from chromatin
during DNA replication . . . . . . . . . 1433
G. Sluder and
E. A. Thompson and
C. L. Rieder and
F. J. Miller Nuclear envelope breakdown is under
nuclear not cytoplasmic control in sea
urchin zygotes . . . . . . . . . . . . . 1447
E. Meier and
B. R. Miller and
D. J. Forbes Nuclear pore complex assembly studied
with a biochemical assay for annulate
lamellae formation . . . . . . . . . . . 1459
I. Török and
D. Strand and
R. Schmitt and
G. Tick and
T. Török and
I. Kiss and
B. M. Mechler The overgrown hematopoietic organs-31
tumor suppressor gene of
\bionameDrosophila encodes an
Importin-like protein accumulating in
the nucleus at the onset of mitosis . . 1473
P. Küssel and
M. Frasch Pendulin, a \bionameDrosophila protein
with cell cycle-dependent nuclear
localization, is required for normal
cell proliferation . . . . . . . . . . . 1491
E. W. Marsh and
P. L. Leopold and
N. L. Jones and
F. R. Maxfield Oligomerized transferrin receptors are
selectively retained by a lumenal
sorting signal in a long-lived endocytic
recycling compartment . . . . . . . . . 1509
C. C. Mastick and
M. J. Brady and
A. R. Saltiel Insulin stimulates the tyrosine
phosphorylation of caveolin . . . . . . 1523
D. J. FitzGerald and
C. M. Fryling and
A. Zdanovsky and
C. B. Saelinger and
M. Kounnas and
J. A. Winkles and
D. Strickland and
S. Leppla Pseudomonas exotoxin-mediated selection
yields cells with altered expression of
low-density lipoprotein receptor-related
protein . . . . . . . . . . . . . . . . 1533
T. W. Gadella and
T. M. Jovin Oligomerization of epidermal growth
factor receptors on A431 cells studied
by time-resolved fluorescence imaging
microscopy. A stereochemical model for
tyrosine kinase receptor activation . . 1543
Y. Sako and
A. Kusumi Barriers for lateral diffusion of
transferrin receptor in the plasma
membrane as characterized by receptor
dragging by laser tweezers: fence versus
tether . . . . . . . . . . . . . . . . . 1559
V. Mermall and
K. G. Miller The 95F unconventional myosin is
required for proper organization of the
\bionameDrosophila syncytial blastoderm 1575
C. C. Cunningham Actin polymerization and intracellular
solvent flow in cell surface blebbing 1589
M. Winey and
C. L. Mamay and
E. T. O'Toole and
D. N. Mastronarde and
T. H. Giddings and
K. L. McDonald and
J. R. McIntosh Three-dimensional ultrastructural
analysis of the \bionameSaccharomyces
cerevisiae mitotic spindle . . . . . . . 1601
R. M. Golsteyn and
K. E. Mundt and
A. M. Fry and
E. A. Nigg Cell cycle regulation of the activity
and subcellular localization of Plk1, a
human protein kinase implicated in
mitotic spindle function . . . . . . . . 1617
P. H. Tu and
G. Elder and
R. A. Lazzarini and
D. Nelson and
J. Q. Trojanowski and
V. M. Lee Overexpression of the human NFM subunit
in transgenic mice modifies the level of
endogenous NFL and the phosphorylation
state of NFH subunits . . . . . . . . . 1629
X. Zhu and
I. Lindberg 7B2 facilitates the maturation of proPC2
in neuroendocrine cells and is required
for the expression of enzymatic activity 1641
Y. Geng and
M. Lotz Increased intracellular Ca$^{2+}$
selectively suppresses IL-1-induced NO
production by reducing iNOS mRNA
stability . . . . . . . . . . . . . . . 1651
P. J. Lilly and
P. N. Devreotes Chemoattractant and GTP gamma S-mediated
stimulation of adenylyl cyclase in
\bionameDictyostelium requires
translocation of CRAC to membranes . . . 1659
L. Wu and
R. Valkema and
P. J. Van Haastert and
P. N. Devreotes The G protein beta subunit is essential
for multiple responses to
chemoattractants in
\bionameDictyostelium . . . . . . . . . 1667
R. H. Brakenhoff and
M. Gerretsen and
E. M. Knippels and
M. van Dijk and
H. van Essen and
D. O. Weghuis and
R. J. Sinke and
G. B. Snow and
G. A. van Dongen The human E48 antigen, highly homologous
to the murine Ly-6 antigen ThB, is a
GPI-anchored molecule apparently
involved in keratinocyte cell--cell
adhesion . . . . . . . . . . . . . . . . 1677
K. Nakamura and
R. Iwamoto and
E. Mekada Membrane-anchored heparin-binding
EGF-like growth factor (HB--EGF) and
diphtheria toxin receptor-associated
protein (DRAP27)/CD9 form a complex with
integrin alpha 3 beta 1 at cell--cell
contact sites . . . . . . . . . . . . . 1691
P. Tremble and
C. H. Damsky and
Z. Werb Components of the nuclear signaling
cascade that regulate collagenase gene
expression in response to
integrin-derived signals . . . . . . . . 1707
F. Korioth and
C. Gieffers and
G. G. Maul and
J. Frey Molecular characterization of NDP52, a
novel protein of the nuclear domain 10,
which is redistributed upon virus
infection and interferon treatment . . . 1
B. Soullam and
H. J. Worman Signals and structural features involved
in integral membrane protein targeting
to the inner nuclear membrane . . . . . 15
E. E. Wanker and
Y. Sun and
A. J. Savitz and
D. I. Meyer Functional characterization of the
180-kD ribosome receptor in vivo . . . . 29
J. F. Simons and
S. Ferro-Novick and
M. D. Rose and
A. Helenius BiP\slash Kar2p serves as a molecular
chaperone during carboxypeptidase Y
folding in yeast . . . . . . . . . . . . 41
E. A. Wiemer and
W. M. Nuttley and
B. L. Bertolaet and
X. Li and
U. Francke and
M. J. Wheelock and
U. K. Anné and
K. R. Johnson and
S. Subramani Human peroxisomal targeting signal-1
receptor restores peroxisomal protein
import in cells from patients with fatal
peroxisomal disorders . . . . . . . . . 51
K. A. Knudsen and
A. P. Soler and
K. R. Johnson and
M. J. Wheelock Interaction of alpha-actinin with the
cadherin/catenin cell--cell adhesion
complex via alpha-catenin . . . . . . . 67
M. Durbeej and
E. Larsson and
O. Ibraghimov-Beskrovnaya and
S. L. Roberds and
K. P. Campbell and
P. Ekblom Non-muscle alpha-dystroglycan is
involved in epithelial development . . . 79
D. J. Sharp and
W. Yu and
P. W. Baas Transport of dendritic microtubules
establishes their nonuniform polarity
orientation . . . . . . . . . . . . . . 93
R. Balczon and
L. Bao and
W. E. Zimmer and
K. Brown and
R. P. Zinkowski and
B. R. Brinkley Dissociation of centrosome replication
events from cycles of DNA synthesis and
mitotic division in hydroxyurea-arrested
Chinese hamster ovary cells . . . . . . 105
S. B. Hopkinson and
S. E. Baker and
J. C. Jones Molecular genetic studies of a human
epidermal autoantigen (the 180-kD
bullous pemphigoid antigen/BP180):
identification of functionally important
sequences within the BP180 molecule and
evidence for an interaction between
BP180 and alpha 6 integrin . . . . . . . 117
J. A. Loeb and
G. D. Fischbach ARIA can be released from extracellular
matrix through cleavage of a
heparin-binding domain . . . . . . . . . 127
M. Trupp and
M. Rydén and
H. Jörnvall and
H. Funakoshi and
T. Timmusk and
E. Arenas and
C. F. Ibáñez Peripheral expression and biological
activities of GDNF, a new neurotrophic
factor for avian and mammalian
peripheral neurons . . . . . . . . . . . 137
M. D. Ehlers and
D. R. Kaplan and
D. L. Price and
V. E. Koliatsos NGF-stimulated retrograde transport of
trkA in the mammalian nervous system . . 149
P. X. Petit and
H. Lecoeur and
E. Zorn and
C. Dauguet and
B. Mignotte and
M. L. Gougeon Alterations in mitochondrial structure
and function are early events of
dexamethasone-induced thymocyte
apoptosis . . . . . . . . . . . . . . . 157
W. C. Li and
J. R. Kuszak and
K. Dunn and
R. R. Wang and
W. Ma and
G. M. Wang and
A. Spector and
M. Leib and
A. M. Cotliar and
M. Weiss Lens epithelial cell apoptosis appears
to be a common cellular basis for
non-congenital cataract development in
humans and animals . . . . . . . . . . . 169
I. Screpanti and
S. Scarpa and
D. Meco and
D. Bellavia and
L. Stuppia and
L. Frati and
A. Modesti and
A. Gulino Epidermal growth factor promotes a
neural phenotype in thymic epithelial
cells and enhances neuropoietic cytokine
expression . . . . . . . . . . . . . . . 183
K. E. Bornfeldt and
L. M. Graves and
E. W. Raines and
Y. Igarashi and
G. Wayman and
S. Yamamura and
Y. Yatomi and
J. S. Sidhu and
E. G. Krebs and
S. Hakomori Sphingosine-$1$-phosphate inhibits
PDGF-induced chemotaxis of human
arterial smooth muscle cells: spatial
and temporal modulation of PDGF
chemotactic signal transduction . . . . 193
D. G. Chalupowicz and
Z. A. Chowdhury and
T. L. Bach and
C. Barsigian and
J. Martinez Fibrin II induces endothelial cell
capillary tube formation . . . . . . . . 207
H. Yamashita and
P. ten Dijke and
D. Huylebroeck and
T. K. Sampath and
M. Andries and
J. C. Smith and
C. H. Heldin and
K. Miyazono Osteogenic protein-1 binds to activin
type II receptors and induces certain
activin-like effects . . . . . . . . . . 217
X. Liu and
H. Wu and
M. Byrne and
J. Jeffrey and
S. Krane and
R. Jaenisch A targeted mutation at the known
collagenase cleavage site in mouse type
I collagen impairs tissue remodeling . . 227
G. Fang and
T. R. Cech Telomerase RNA localized in the
replication band and spherical
subnuclear organelles in hypotrichous
ciliates . . . . . . . . . . . . . . . . 243
T. Tagawa and
T. Kuroki and
P. K. Vogt and
K. Chida The cell cycle-dependent nuclear import
of v--Jun is regulated by
phosphorylation of a serine adjacent to
the nuclear localization signal . . . . 255
N. C. Chi and
E. J. Adam and
S. A. Adam Sequence and characterization of
cytoplasmic nuclear protein import
factor p97 . . . . . . . . . . . . . . . 265
C. J. Gallo and
A. R. Hand and
T. L. Jones and
L. A. Jaffe Stimulation of \bionameXenopus oocyte
maturation by inhibition of the
G-protein alpha S subunit, a component
of the plasma membrane and yolk platelet
membranes . . . . . . . . . . . . . . . 275
J. M. Wahlberg and
I. Geffen and
F. Reymond and
T. Simmen and
M. Spiess trans-Golgi retention of a plasma
membrane protein: mutations in the
cytoplasmic domain of the
asialoglycoprotein receptor subunit H1
result in trans-Golgi retention . . . . 285
D. R. TerBush and
P. Novick Sec6, Sec8, and Sec15 are components of
a multisubunit complex which localizes
to small bud tips in
\bionameSaccharomyces cerevisiae . . . . 299
L. L. Peters and
K. M. John and
F. M. Lu and
E. M. Eicher and
A. Higgins and
M. Yialamas and
L. C. Turtzo and
A. J. Otsuka and
S. E. Lux Ank3 (epithelial ankyrin), a widely
distributed new member of the ankyrin
gene family and the major ankyrin in
kidney, is expressed in alternatively
spliced forms, including forms that lack
the repeat domain . . . . . . . . . . . 313
J. B. Marchand and
P. Moreau and
A. Paoletti and
P. Cossart and
M. F. Carlier and
D. Pantaloni Actin-based movement of \bionameListeria
monocytogenes: actin assembly results
from the local maintenance of uncapped
filament barbed ends at the bacterium
surface . . . . . . . . . . . . . . . . 331
V. R. Simon and
T. C. Swayne and
L. A. Pon Actin-dependent mitochondrial motility
in mitotic yeast and cell-free systems:
identification of a motor activity on
the mitochondrial surface . . . . . . . 345
J. H. Chang and
S. Gill and
J. Settleman and
S. J. Parsons c-Src regulates the simultaneous
rearrangement of actin cytoskeleton,
p190RhoGAP, and p120RasGAP following
epidermal growth factor stimulation . . 355
J. M. Staddon and
C. Smales and
C. Schulze and
F. S. Esch and
L. L. Rubin p120, a p120-related protein (p100), and
the cadherin/catenin complex . . . . . . 369
M. Demetriou and
I. R. Nabi and
M. Coppolino and
S. Dedhar and
J. W. Dennis Reduced contact-inhibition and
substratum adhesion in epithelial cells
expressing GlcNAc-transferase V . . . . 383
F. Strutz and
H. Okada and
C. W. Lo and
T. Danoff and
R. L. Carone and
J. E. Tomaszewski and
E. G. Neilson Identification and characterization of a
fibroblast marker: FSP1 . . . . . . . . 393
T. A. Mitsiadis and
M. Lardelli and
U. Lendahl and
I. Thesleff Expression of Notch 1, 2 and 3 is
regulated by epithelial-mesenchymal
interactions and retinoic acid in the
developing mouse tooth and associated
with determination of ameloblast cell
fate . . . . . . . . . . . . . . . . . . 407
R. Sullivan and
C. W. Lo Expression of a connexin
43/beta-galactosidase fusion protein
inhibits gap junctional communication in
NIH3T3 cells . . . . . . . . . . . . . . 419
S. J. Pittler and
S. J. Fliesler and
P. L. Fisher and
P. K. Keller and
L. M. Rapp In vivo requirement of protein
prenylation for maintenance of retinal
cytoarchitecture and photoreceptor
structure . . . . . . . . . . . . . . . 431
E. J. Filardo and
P. C. Brooks and
S. L. Deming and
C. Damsky and
D. A. Cheresh Requirement of the NPXY motif in the
integrin beta 3 subunit cytoplasmic tail
for melanoma cell migration in vitro and
in vivo . . . . . . . . . . . . . . . . 441
L. Piali and
P. Hammel and
C. Uherek and
F. Bachmann and
R. H. Gisler and
D. Dunon and
B. A. Imhof CD31\slash PECAM-1 is a ligand for alpha
v beta 3 integrin involved in adhesion
of leukocytes to endothelium . . . . . . 451
M. S. Kinch and
G. J. Clark and
C. J. Der and
K. Burridge Tyrosine phosphorylation regulates the
adhesions of ras-transformed breast
epithelia . . . . . . . . . . . . . . . 461
U. Nörenberg and
M. Hubert and
T. Brümmendorf and
A. Tárnok and
F. G. Rathjen Characterization of functional domains
of the tenascin--R (restrictin)
polypeptide: cell attachment site,
binding with F11, and enhancement of
F11-mediated neurite outgrowth by
tenascin--R . . . . . . . . . . . . . . 473
Z. Zheng and
S. Katoh and
Q. He and
K. Oritani and
K. Miyake and
J. Lesley and
R. Hyman and
A. Hamik and
R. M. Parkhouse and
A. G. Farr Monoclonal antibodies to CD44 and their
influence on hyaluronan recognition . . 485
P. Bornstein Diversity of function is inherent in
matricellular proteins: an appraisal of
thrombospondin 1 . . . . . . . . . . . . 503
H. Liao and
R. J. Winkfein and
G. Mack and
J. B. Rattner and
T. J. Yen CENP-F is a protein of the nuclear
matrix that assembles onto kinetochores
at late G2 and is rapidly degraded after
mitosis . . . . . . . . . . . . . . . . 507
S. Wang and
H. Sakai and
M. Wiedmann NAC covers ribosome-associated nascent
chains thereby forming a protective
environment for regions of nascent
chains just emerging from the peptidyl
transferase center . . . . . . . . . . . 519
J. S. Rush and
C. J. Waechter Transmembrane movement of a
water-soluble analogue of
mannosylphosphoryldolichol is mediated
by an endoplasmic reticulum protein . . 529
B. Volz and
G. Orberger and
S. Porwoll and
H. P. Hauri and
R. Tauber Selective reentry of recycling cell
surface glycoproteins to the
biosynthetic pathway in human
hepatocarcinoma HepG2 cells . . . . . . 537
A. E. Gammie and
L. J. Kurihara and
R. B. Vallee and
M. D. Rose DNM1, a dynamin-related gene,
participates in endosomal trafficking in
yeast . . . . . . . . . . . . . . . . . 553
D. Karaoglu and
D. J. Kelleher and
R. Gilmore Functional characterization of Ost3p.
Loss of the 34-kD subunit of the
\bionameSaccharomyces cerevisiae
oligosaccharyltransferase results in
biased underglycosylation of acceptor
substrates . . . . . . . . . . . . . . . 567
B. F. Roettger and
R. U. Rentsch and
E. M. Hadac and
E. H. Hellen and
T. P. Burghardt and
L. J. Miller Insulation of a G protein-coupled
receptor on the plasmalemmal surface of
the pancreatic acinar cell . . . . . . . 579
I. C. Baines and
A. Corigliano-Murphy and
E. D. Korn Quantification and localization of
phosphorylated myosin I isoforms in
Acanthamoeba castellanii . . . . . . . . 591
C. G. Burns and
M. Reedy and
J. Heuser and
A. De Lozanne Expression of light meromyosin in
\bionameDictyostelium blocks normal
myosin II function . . . . . . . . . . . 605
Z. M. Goeckeler and
R. B. Wysolmerski Myosin light chain kinase-regulated
endothelial cell contraction: the
relationship between isometric tension,
actin polymerization, and myosin
phosphorylation . . . . . . . . . . . . 613
L. G. Tilney and
M. S. Tilney and
G. M. Guild F actin bundles in \bionameDrosophila
bristles. I. Two filament cross-links
are involved in bundling . . . . . . . . 629
K. R. Olson and
J. R. McIntosh and
J. B. Olmsted Analysis of MAP 4 function in living
cells using green fluorescent protein
(GFP) chimeras . . . . . . . . . . . . . 639
D. McCollum and
M. K. Balasubramanian and
L. E. Pelcher and
S. M. Hemmingsen and
K. L. Gould \bionameSchizosaccharomyces pombe cdc4+
gene encodes a novel EF-hand protein
essential for cytokinesis . . . . . . . 651
D. R. Kellogg and
A. Kikuchi and
T. Fujii-Nakata and
C. W. Turck and
A. W. Murray Members of the NAP/SET family of
proteins interact specifically with
B-type cyclins . . . . . . . . . . . . . 661
D. R. Kellogg and
A. W. Murray NAP1 acts with Clb1 to perform mitotic
functions and to suppress polar bud
growth in budding yeast . . . . . . . . 675
E. Yeh and
R. V. Skibbens and
J. W. Cheng and
E. D. Salmon and
K. Bloom Spindle dynamics and cell cycle
regulation of dynein in the budding
yeast, \bionameSaccharomyces cerevisiae 687
M. D. Mark and
Y. Liu and
S. T. Wong and
T. R. Hinds and
D. R. Storm Stimulation of neurite outgrowth in PC12
cells by EGF and KCl depolarization: a
Ca(2+)-independent phenomenon . . . . . 701
S. D. Gross and
D. P. Hoffman and
P. L. Fisette and
P. Baas and
R. A. Anderson A phosphatidylinositol
4,5-bisphosphate-sensitive casein kinase
I alpha associates with synaptic
vesicles and phosphorylates a subset of
vesicle proteins . . . . . . . . . . . . 711
V. Kundra and
B. Anand-Apte and
L. A. Feig and
B. R. Zetter The chemotactic response to PDGF--BB:
evidence of a role for Ras . . . . . . . 725
M. P. Burgoon and
R. B. Hazan and
G. R. Phillips and
K. L. Crossin and
G. M. Edelman and
B. A. Cunningham Functional analysis of posttranslational
cleavage products of the neuron-glia
cell adhesion molecule, Ng--CAM . . . . 733
S. D. Blystone and
F. P. Lindberg and
S. E. LaFlamme and
E. J. Brown Integrin beta 3 cytoplasmic tail is
necessary and sufficient for regulation
of alpha 5 beta 1 phagocytosis by alpha
v beta 3 and integrin-associated protein 745
P. K. Jackson and
S. Chevalier and
M. Philippe and
M. W. Kirschner Early events in DNA replication require
cyclin E and are blocked by p21CIP1 . . 755
C. Labriola and
J. J. Cazzulo and
A. J. Parodi Retention of glucose units added by the
UDP--GLC: glycoprotein
glucosyltransferase delays exit of
glycoproteins from the endoplasmic
reticulum . . . . . . . . . . . . . . . 771
W. J. Brown and
D. B. DeWald and
S. D. Emr and
H. Plutner and
W. E. Balch Role for phosphatidylinositol $3$-kinase
in the sorting and transport of newly
synthesized lysosomal enzymes in
mammalian cells . . . . . . . . . . . . 781
H. W. Davidson Wortmannin causes mistargeting of
procathepsin D. Evidence for the
involvement of a phosphatidylinositol
$3$-kinase in vesicular transport to
lysosomes . . . . . . . . . . . . . . . 797
S. Vijayasaradhi and
Y. Xu and
B. Bouchard and
A. N. Houghton Intracellular sorting and targeting of
melanosomal membrane proteins:
identification of signals for sorting of
the human brown locus protein, gp75 . . 807
A. W. van Weert and
K. W. Dunn and
H. J. Gueze and
F. R. Maxfield and
W. Stoorvogel Transport from late endosomes to
lysosomes, but not sorting of integral
membrane proteins in endosomes, depends
on the vacuolar proton pump . . . . . . 821
T. A. Nicolson and
L. S. Weisman and
G. S. Payne and
W. T. Wickner A truncated form of the Pho80 cyclin
redirects the Pho85 kinase to disrupt
vacuole inheritance in S. cerevisiae . . 835
C. Bastianutto and
E. Clementi and
F. Codazzi and
P. Podini and
F. De Giorgi and
R. Rizzuto and
J. Meldolesi and
T. Pozzan Overexpression of calreticulin increases
the Ca$^{2+}$ capacity of rapidly
exchanging Ca$^{2+}$ stores and reveals
aspects of their lumenal
microenvironment and function . . . . . 847
L. D. Walensky and
S. H. Snyder Inositol 1,4,5-trisphosphate receptors
selectively localized to the acrosomes
of mammalian sperm . . . . . . . . . . . 857
L. Castellani and
M. C. Reedy and
M. C. Gauzzi and
C. Provenzano and
S. Alem\`a and
G. Falcone Maintenance of the differentiated state
in skeletal muscle: activation of v--Src
disrupts sarcomeres in quail myotubes 871
C. Chaponnier and
M. Goethals and
P. A. Janmey and
F. Gabbiani and
G. Gabbiani and
J. Vandekerckhove The specific NH2-terminal sequence
Ac--EEED of alpha-smooth muscle actin
plays a role in polymerization in vitro
and in vivo . . . . . . . . . . . . . . 887
D. E. Discher and
R. Winardi and
P. O. Schischmanoff and
M. Parra and
J. G. Conboy and
N. Mohandas Mechanochemistry of protein 4.1's
spectrin-actin-binding domain: ternary
complex interactions, membrane binding,
network integration, structural
strengthening . . . . . . . . . . . . . 897
B. Mickey and
J. Howard Rigidity of microtubules is increased by
stabilizing agents . . . . . . . . . . . 909
B. M. Lange and
K. Gull A molecular marker for centriole
maturation in the mammalian cell cycle 919
R. B. Nicklas and
S. C. Ward and
G. J. Gorbsky Kinetochore chemistry is sensitive to
tension and may link mitotic forces to a
cell cycle checkpoint . . . . . . . . . 929
C. L. Rieder and
R. W. Cole and
A. Khodjakov and
G. Sluder The checkpoint delaying anaphase in
response to chromosome monoorientation
is mediated by an inhibitory signal
produced by unattached kinetochores . . 941
W. A. Kues and
H. R. Brenner and
B. Sakmann and
V. Witzemann Local neurotrophic repression of gene
transcripts encoding fetal AChRs at rat
neuromuscular synapses . . . . . . . . . 949
C. Antony and
M. Huchet and
J. P. Changeux and
J. Cartaud Developmental regulation of membrane
traffic organization during
synaptogenesis in mouse diaphragm muscle 959
M. Bastmeyer and
H. Ott and
C. A. Leppert and
C. A. Stuermer Fish E587 glycoprotein, a member of the
L1 family of cell adhesion molecules,
participates in axonal fasciculation and
the age-related order of ganglion cell
axons in the goldfish retina . . . . . . 969
S. M. Brady-Kalnay and
D. L. Rimm and
N. K. Tonks Receptor protein tyrosine phosphatase
PTPmu associates with cadherins and
catenins in vivo . . . . . . . . . . . . 977
M. Koval and
S. T. Geist and
E. M. Westphale and
A. E. Kemendy and
R. Civitelli and
E. C. Beyer and
T. H. Steinberg Transfected connexin45 alters gap
junction permeability in cells
expressing endogenous connexin43 . . . . 987
T. Ochiya and
H. Sakamoto and
M. Tsukamoto and
T. Sugimura and
M. Terada Hst-1 (FGF-4) antisense oligonucleotides
block murine limb development . . . . . 997
M. Koch and
B. Bohrmann and
M. Matthison and
C. Hagios and
B. Trueb and
M. Chiquet Large and small splice variants of
collagen XII: differential expression
and ligand binding . . . . . . . . . . . 1005
A. H. Corbett and
D. M. Koepp and
G. Schlenstedt and
M. S. Lee and
A. K. Hopper and
P. A. Silver RNA1p, a Ran/TC4 GTPase activating
protein, is required for nuclear import 1017
T. Misteli and
G. Warren A role for tubular networks and a COP
I-independent pathway in the mitotic
fragmentation of Golgi stacks in a
cell-free system . . . . . . . . . . . . 1027
C. Desnos and
L. Clift-O'Grady and
R. B. Kelly Biogenesis of synaptic vesicles in vitro 1041
S. Jones and
R. J. Litt and
C. J. Richardson and
N. Segev Requirement of nucleotide exchange
factor for Ypt1 GTPase mediated protein
transport . . . . . . . . . . . . . . . 1051
L. H. Chamberlain and
D. Roth and
A. Morgan and
R. D. Burgoyne Distinct effects of alpha--SNAP, 14-3-3
proteins, and calmodulin on priming and
triggering of regulated exocytosis . . . 1063
K. J. Verhey and
J. I. Yeh and
M. J. Birnbaum Distinct signals in the GLUT4 glucose
transporter for internalization and for
targeting to an insulin-responsive
compartment . . . . . . . . . . . . . . 1071
B. J. Marsh and
R. A. Alm and
S. R. McIntosh and
D. E. James Molecular regulation of GLUT-4 targeting
in 3T3-L1 adipocytes . . . . . . . . . . 1081
A. R. Robbins and
R. D. Ward and
C. Oliver A mutation in glyceraldehyde
$3$-phosphate dehydrogenase alters
endocytosis in CHO cells . . . . . . . . 1093
R. W. Mays and
K. A. Siemers and
B. A. Fritz and
A. W. Lowe and
G. van Meer and
W. J. Nelson Hierarchy of mechanisms involved in
generating Na/K--ATPase polarity in MDCK
epithelial cells . . . . . . . . . . . . 1105
A. Shaw and
P. A. Fortes and
C. D. Stout and
V. D. Vacquier Crystal structure and subunit dynamics
of the abalone sperm lysin dimer: egg
envelopes dissociate dimers, the monomer
is the active species . . . . . . . . . 1117
S. J. Kang and
K. S. Shin and
W. K. Song and
D. B. Ha and
C. H. Chung and
M. S. Kang Involvement of transglutaminase in
myofibril assembly of chick embryonic
myoblasts in culture . . . . . . . . . . 1127
H. B. Shu and
H. C. Joshi Gamma-tubulin can both nucleate
microtubule assembly and self-assemble
into novel tubular structures in
mammalian cells . . . . . . . . . . . . 1137
M. Moritz and
M. B. Braunfeld and
J. C. Fung and
J. W. Sedat and
B. M. Alberts and
D. A. Agard Three-dimensional structural
characterization of centrosomes from
early \bionameDrosophila embryos . . . . 1149
C. M. Waterman-Storer and
J. Gregory and
S. F. Parsons and
E. D. Salmon Membrane\slash microtubule tip
attachment complexes (TACs) allow the
assembly dynamics of plus ends to push
and pull membranes into tubulovesicular
networks in interphase \bionameXenopus
egg extracts . . . . . . . . . . . . . . 1161
S. Haas and
P. Thatikunta and
A. Steplewski and
E. M. Johnson and
K. Khalili and
S. Amini A 39-kD DNA-binding protein from mouse
brain stimulates transcription of myelin
basic protein gene in oligodendrocytic
cells . . . . . . . . . . . . . . . . . 1171
M. D. Schaller and
C. A. Otey and
J. D. Hildebrand and
J. T. Parsons Focal adhesion kinase and paxillin bind
to peptides mimicking beta integrin
cytoplasmic domains . . . . . . . . . . 1181
R. Pasqualini and
E. Koivunen and
E. Ruoslahti A peptide isolated from phage display
libraries is a structural and functional
mimic of an RGD-binding site on
integrins . . . . . . . . . . . . . . . 1189
Y. He and
F. Grinnell Role of phospholipase D in the cAMP
signal transduction pathway activated
during fibroblast contraction of
collagen matrices . . . . . . . . . . . 1197
K. Watanabe and
H. Yamada and
Y. Yamaguchi K-glypican: a novel GPI-anchored heparan
sulfate proteoglycan that is highly
expressed in developing brain and kidney 1207
Y. Ninomiya and
M. Kagawa and
K. Iyama and
I. Naito and
Y. Kishiro and
J. M. Seyer and
M. Sugimoto and
T. Oohashi and
Y. Sado Differential expression of two basement
membrane collagen genes, COL4A6 and
COL4A5, demonstrated by
immunofluorescence staining using
peptide-specific monoclonal antibodies 1219
H. Yokota and
G. van den Engh and
J. E. Hearst and
R. K. Sachs and
B. J. Trask Evidence for the organization of
chromatin in megabase pair-sized loops
arranged along a random walk path in the
human G0/G1 interphase nucleus . . . . . 1239
A. Böttger and
B. A. Spruce Proenkephalin is a nuclear protein
responsive to growth arrest and
differentiation signals . . . . . . . . 1251
P. Grandi and
S. Emig and
C. Weise and
F. Hucho and
T. Pohl and
E. C. Hurt A novel nuclear pore protein Nup82p
which specifically binds to a fraction
of Nsp1p . . . . . . . . . . . . . . . . 1263
M. E. Hurwitz and
G. Blobel NUP82 is an essential yeast nucleoporin
required for poly(A)+ RNA export . . . . 1275
E. A. Elion and
J. Trueheart and
G. R. Fink Fus2 localizes near the site of cell
fusion and is required for both cell
fusion and nuclear alignment during
zygote formation . . . . . . . . . . . . 1283
J. Rohrer and
A. Schweizer and
K. F. Johnson and
S. Kornfeld A determinant in the cytoplasmic tail of
the cation-dependent mannose
$6$-phosphate receptor prevents
trafficking to lysosomes . . . . . . . . 1297
K. Matsuoka and
D. C. Bassham and
N. V. Raikhel and
K. Nakamura Different sensitivity to wortmannin of
two vacuolar sorting signals indicates
the presence of distinct sorting
machineries in tobacco cells . . . . . . 1307
G. Schmalzing and
H. P. Richter and
A. Hansen and
W. Schwarz and
I. Just and
K. Aktories Involvement of the GTP binding protein
Rho in constitutive endocytosis in
\bionameXenopus laevis oocytes . . . . . 1319
M. Benghezal and
P. N. Lipke and
A. Conzelmann Identification of six complementation
classes involved in the biosynthesis of
glycosylphosphatidylinositol anchors in
\bionameSaccharomyces cerevisiae . . . . 1333
A. L. Samuels and
T. H. Giddings and
L. A. Staehelin Cytokinesis in tobacco BY-2 and root tip
cells: a new model of cell plate
formation in higher plants . . . . . . . 1345
H. Sawitzky and
F. Grolig Phragmoplast of the green alga Spirogyra
is functionally distinct from the higher
plant phragmoplast . . . . . . . . . . . 1359
D. Pellman and
M. Bagget and
Y. H. Tu and
G. R. Fink and
H. Tu Two microtubule-associated proteins
required for anaphase spindle movement
in \bionameSaccharomyces cerevisiae . . 1373
H. Yamazaki and
T. Nakata and
Y. Okada and
N. Hirokawa KIF3A\slash B: a heterodimeric kinesin
superfamily protein that works as a
microtubule plus end-directed motor for
membrane organelle transport . . . . . . 1387
I. Huttenlauch and
N. Geisler and
U. Plessmann and
R. K. Peck and
K. Weber and
R. Stick Major epiplasmic proteins of ciliates
are articulins: cloning, recombinant
expression, and structural
characterization . . . . . . . . . . . . 1401
P. C. Wong and
J. Marszalek and
T. O. Crawford and
Z. Xu and
S. T. Hsieh and
J. W. Griffin and
D. W. Cleveland Increasing neurofilament subunit NF--M
expression reduces axonal NF--H,
inhibits radial growth, and results in
neurofilamentous accumulation in motor
neurons . . . . . . . . . . . . . . . . 1413
A. D. Goodearl and
A. G. Yee and
A. W. Sandrock and
G. Corfas and
G. D. Fischbach ARIA is concentrated in the synaptic
basal lamina of the developing chick
neuromuscular junction . . . . . . . . . 1423
S. Wyatt and
A. M. Davies Regulation of nerve growth factor
receptor gene expression in sympathetic
neurons during development . . . . . . . 1435
M. de Hoop and
C. von Poser and
C. Lange and
E. Ikonen and
W. Hunziker and
C. G. Dotti Intracellular routing of wild-type and
mutated polymeric immunoglobulin
receptor in hippocampal neurons in
culture . . . . . . . . . . . . . . . . 1447
A. Poliard and
A. Nifuji and
D. Lamblin and
E. Plee and
C. Forest and
O. Kellermann Controlled conversion of an immortalized
mesodermal progenitor cell towards
osteogenic, chondrogenic, or adipogenic
pathways . . . . . . . . . . . . . . . . 1461
M. S. Diamond and
R. Alon and
C. A. Parkos and
M. T. Quinn and
T. A. Springer Heparin is an adhesive ligand for the
leukocyte integrin Mac-1 (CD11b/CD1) . . 1473
K. G. Miller and
D. P. Kiehart Fly division . . . . . . . . . . . . . . 1
J. F. Giménez-Abián and
D. J. Clarke and
A. M. Mullinger and
C. S. Downes and
R. T. Johnson A postprophase topoisomerase
II-dependent chromatid core separation
step in the formation of metaphase
chromosomes . . . . . . . . . . . . . . 7
C. Strambio-de-Castillia and
G. Blobel and
M. P. Rout Isolation and characterization of
nuclear envelopes from the yeast
Saccharomyces . . . . . . . . . . . . . 19
H. Taniura and
C. Glass and
L. Gerace A chromatin binding site in the tail
domain of nuclear lamins that interacts
with core histones . . . . . . . . . . . 33
T. Carvalho and
J. S. Seeler and
K. Ohman and
P. Jordan and
U. Pettersson and
G. Akusjärvi and
M. Carmo-Fonseca and
A. Dejean Targeting of adenovirus E1A and E4-ORF3
proteins to nuclear matrix-associated
PML bodies . . . . . . . . . . . . . . . 45
C. Itin and
R. Schindler and
H. P. Hauri Targeting of protein ERGIC-53 to the
ER/ERGIC/cis-Golgi recycling pathway . . 57
H. Damke and
T. Baba and
A. M. van der Bliek and
S. L. Schmid Clathrin-independent pinocytosis is
induced in cells overexpressing a
temperature-sensitive mutant of dynamin 69
P. Y. Lum and
R. Wright Degradation of HMG--CoA
reductase-induced membranes in the
fission yeast,
\bionameSchizosaccharomyces pombe . . . 81
A. Motley and
M. J. Lumb and
P. B. Oatey and
P. R. Jennings and
P. A. De Zoysa and
R. J. Wanders and
H. F. Tabak and
C. J. Danpure Mammalian alanine/glyoxylate
aminotransferase 1 is imported into
peroxisomes via the PTS1 translocation
pathway. Increased degeneracy and
context specificity of the mammalian
PTS1 motif and implications for the
peroxisome-to-mitochondrion mistargeting
of AGT in primary hyperoxaluria type 1 95
E. Prchla and
C. Plank and
E. Wagner and
D. Blaas and
R. Fuchs Virus-mediated release of endosomal
content in vitro: different behavior of
adenovirus and rhinovirus serotype 2 . . 111
S. Parpal and
J. Gustavsson and
P. Strålfors Isolation of
phosphooligosaccharide/phosphoinositol
glycan from caveolae and cytosol of
insulin-stimulated cells . . . . . . . . 125
R. Mayer and
J. Kartenbeck and
M. Büchler and
G. Jedlitschky and
I. Leier and
D. Keppler Expression of the MRP gene-encoded
conjugate export pump in liver and its
selective absence from the canalicular
membrane in transport-deficient mutant
hepatocytes . . . . . . . . . . . . . . 137
S. Eaton and
P. Auvinen and
L. Luo and
Y. N. Jan and
K. Simons CDC42 and Rac1 control different
actin-dependent processes in the
\bionameDrosophila wing disc epithelium 151
C. M. Field and
B. M. Alberts Anillin, a contractile ring protein that
cycles from the nucleus to the cell
cortex . . . . . . . . . . . . . . . . . 165
L. P. Cramer and
T. J. Mitchison Myosin is involved in postmitotic cell
spreading . . . . . . . . . . . . . . . 179
S. N. Martineau and
P. R. Andreassen and
R. L. Margolis Delay of HeLa cell cleavage into
interphase using dihydrocytochalasin B:
retention of a postmitotic spindle and
telophase disc correlates with
synchronous cleavage recovery . . . . . 191
Q. Li and
H. C. Joshi gamma-tubulin is a minus end-specific
microtubule binding protein . . . . . . 207
Y. Yang and
E. Spitzer and
D. Meyer and
M. Sachs and
C. Niemann and
G. Hartmann and
K. M. Weidner and
C. Birchmeier and
W. Birchmeier Sequential requirement of hepatocyte
growth factor and neuregulin in the
morphogenesis and differentiation of the
mammary gland . . . . . . . . . . . . . 215
O. Kranenburg and
V. Scharnhorst and
A. J. Van der Eb and
A. Zantema Inhibition of cyclin-dependent kinase
activity triggers neuronal
differentiation of mouse neuroblastoma
cells . . . . . . . . . . . . . . . . . 227
Z. Fan and
Y. Lu and
X. Wu and
A. DeBlasio and
A. Koff and
J. Mendelsohn Prolonged induction of
p21Cip1/WAF1/CDK2/PCNA complex by
epidermal growth factor receptor
activation mediates ligand-induced A431
cell growth inhibition . . . . . . . . . 235
S. Armeanu and
H. J. Bühring and
M. Reuss-Borst and
C. A. Müller and
G. Klein E-cadherin is functionally involved in
the maturation of the erythroid lineage 243
M. F. Gebbink and
G. C. Zondag and
G. M. Koningstein and
E. Feiken and
R. W. Wubbolts and
W. H. Moolenaar Cell surface expression of receptor
protein tyrosine phosphatase RPTP mu is
regulated by cell--cell contact . . . . 251
K. D. Puri and
E. B. Finger and
G. Gaudernack and
T. A. Springer Sialomucin CD34 is the major L-selectin
ligand in human tonsil high endothelial
venules . . . . . . . . . . . . . . . . 261
T. G. Wolfsberg and
P. Primakoff and
D. G. Myles and
J. M. White ADAM, a novel family of membrane
proteins containing A Disintegrin And
Metalloprotease domain: multipotential
functions in cell--cell and cell-matrix
interactions . . . . . . . . . . . . . . 275
Y. Urata and
S. J. Parmelee and
D. A. Agard and
J. W. Sedat A three-dimensional structural
dissection of \bionameDrosophila
polytene chromosomes . . . . . . . . . . 279
E. Harsay and
A. Bretscher Parallel secretory pathways to the cell
surface in yeast . . . . . . . . . . . . 297
P. Espenshade and
R. E. Gimeno and
E. Holzmacher and
P. Teung and
C. A. Kaiser Yeast SEC16 gene encodes a multidomain
vesicle coat protein that interacts with
Sec23p . . . . . . . . . . . . . . . . . 311
R. E. Gimeno and
P. Espenshade and
C. A. Kaiser SED4 encodes a yeast endoplasmic
reticulum protein that binds Sec16p and
participates in vesicle formation . . . 325
D. J. Opstelten and
M. J. Raamsman and
K. Wolfs and
M. C. Horzinek and
P. J. Rottier Envelope glycoprotein interactions in
coronavirus assembly . . . . . . . . . . 339
M. S. Marks and
P. A. Roche and
E. van Donselaar and
L. Woodruff and
P. J. Peters and
J. S. Bonifacino A lysosomal targeting signal in the
cytoplasmic tail of the beta chain
directs HLA--DM to MHC class II
compartments . . . . . . . . . . . . . . 351
S. Silberstein and
P. G. Collins and
D. J. Kelleher and
R. Gilmore The essential OST2 gene encodes the
16-kD subunit of the yeast
oligosaccharyltransferase, a highly
conserved protein expressed in diverse
eukaryotic organisms . . . . . . . . . . 371
J. F. Kelleher and
S. J. Atkinson and
T. D. Pollard Sequences, structural models, and
cellular localization of the
actin-related proteins Arp2 and Arp3
from Acanthamoeba . . . . . . . . . . . 385
S. M. King and
R. S. Patel-King and
C. G. Wilkerson and
G. B. Witman The 78,000-M(r) intermediate chain of
Chlamydomonas outer arm dynein is a
microtubule-binding protein . . . . . . 399
M. McGrail and
J. Gepner and
A. Silvanovich and
S. Ludmann and
M. Serr and
T. S. Hays Regulation of cytoplasmic dynein
function in vivo by the
\bionameDrosophila Glued complex . . . . 411
G. J. Pazour and
O. A. Sineshchekov and
G. B. Witman Mutational analysis of the
phototransduction pathway of
Chlamydomonas reinhardtii . . . . . . . 427
T. Meier and
G. M. Perez and
B. G. Wallace Immobilization of nicotinic
acetylcholine receptors in mouse C2
myotubes by agrin-induced protein
tyrosine phosphorylation . . . . . . . . 441
J. Frisén and
C. B. Johansson and
C. Török and
M. Risling and
U. Lendahl Rapid, widespread, and longlasting
induction of nestin contributes to the
generation of glial scar tissue after
CNS injury . . . . . . . . . . . . . . . 453
J. P. Doyle and
J. G. Stempak and
P. Cowin and
D. R. Colman and
D. D'Urso Protein zero, a nervous system adhesion
molecule, triggers epithelial reversion
in host carcinoma cells . . . . . . . . 465
H. I. Roach and
J. Erenpreisa and
T. Aigner Osteogenic differentiation of
hypertrophic chondrocytes involves
asymmetric cell divisions and apoptosis 483
M. A. del Pozo and
P. Sánchez-Mateos and
M. Nieto and
F. Sánchez-Madrid Chemokines regulate cellular
polarization and adhesion receptor
redistribution during lymphocyte
interaction with endothelium and
extracellular matrix. Involvement of
cAMP signaling pathway . . . . . . . . . 495
T. Y. Nakamura and
I. Yamamoto and
H. Nishitani and
T. Matozaki and
T. Suzuki and
S. Wakabayashi and
M. Shigekawa and
K. Goshima Detachment of cultured cells from the
substratum induced by the
neutrophil-derived oxidant NH2Cl:
synergistic role of phosphotyrosine and
intracellular Ca$^{2+}$ concentration 509
E. Crowley and
A. F. Horwitz Tyrosine phosphorylation and
cytoskeletal tension regulate the
release of fibroblast adhesions . . . . 525
S. L. Dallas and
K. Miyazono and
T. M. Skerry and
G. R. Mundy and
L. F. Bonewald Dual role for the latent transforming
growth factor-beta binding protein in
storage of latent TGF-beta in the
extracellular matrix and as a structural
matrix protein . . . . . . . . . . . . . 539
L. Bruckner-Tuderman and
O. Nilssen and
D. R. Zimmermann and
M. T. Dours-Zimmermann and
D. U. Kalinke and
T. Gedde-Dahl and
J. O. Winberg Immunohistochemical and mutation
analyses demonstrate that procollagen
VII is processed to collagen VII through
removal of the NC-2 domain . . . . . . . 551
M. Bellini and
J. C. Lacroix and
J. G. Gall A zinc-binding domain is required for
targeting the maternal nuclear protein
PwA33 to lampbrush chromosome loops . . 563
F. Melchior and
T. Guan and
N. Yokoyama and
T. Nishimoto and
L. Gerace GTP hydrolysis by Ran occurs at the
nuclear pore complex in an early step of
protein import . . . . . . . . . . . . . 571
G. Jedd and
C. Richardson and
R. Litt and
N. Segev The Ypt1 GTPase is essential for the
first two steps of the yeast secretory
pathway . . . . . . . . . . . . . . . . 583
T. M. Harding and
K. A. Morano and
S. V. Scott and
D. J. Klionsky Isolation and characterization of yeast
mutants in the cytoplasm to vacuole
protein targeting pathway . . . . . . . 591
R. C. Piper and
A. A. Cooper and
H. Yang and
T. H. Stevens VPS27 controls vacuolar and endocytic
traffic through a prevacuolar
compartment in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 603
L. J. Page and
M. S. Robinson Targeting signals and subunit
interactions in coated vesicle adaptor
complexes . . . . . . . . . . . . . . . 619
J. A. Lorenzen and
C. Y. Dadabay and
E. H. Fischer COOH-terminal sequence motifs target the
T cell protein tyrosine phosphatase to
the ER and nucleus . . . . . . . . . . . 631
I. van Genderen and
G. van Meer Differential targeting of
glucosylceramide and galactosylceramide
analogues after synthesis but not during
transcytosis in Madin--Darby canine
kidney cells . . . . . . . . . . . . . . 645
C. M. Fanger and
M. Hoth and
G. R. Crabtree and
R. S. Lewis Characterization of T cell mutants with
defects in capacitative calcium entry:
genetic evidence for the physiological
roles of CRAC channels . . . . . . . . . 655
C. W. van den Berg and
T. Cinek and
M. B. Hallett and
V. Horejsi and
B. P. Morgan Exogenous glycosyl
phosphatidylinositol-anchored CD59
associates with kinases in membrane
clusters on U937 cells and becomes
Ca(2+)-signaling competent . . . . . . . 669
G. B. Melikyan and
J. M. White and
F. S. Cohen GPI-anchored influenza hemagglutinin
induces hemifusion to both red blood
cell and planar bilayer membranes . . . 679
T. Gaglio and
A. Saredi and
D. A. Compton NuMA is required for the organization of
microtubules into aster-like mitotic
arrays . . . . . . . . . . . . . . . . . 693
K. G. Hardwick and
A. W. Murray Mad1p, a phosphoprotein component of the
spindle assembly checkpoint in budding
yeast . . . . . . . . . . . . . . . . . 709
Y. Zhai and
P. J. Kronebusch and
G. G. Borisy Kinetochore microtubule dynamics and the
metaphase-anaphase transition . . . . . 721
F. Shibasaki and
F. McKeon Calcineurin functions in
Ca(2+)-activated cell death in mammalian
cells . . . . . . . . . . . . . . . . . 735
M. P. Demlehner and
S. Schäfer and
C. Grund and
W. W. Franke Continual assembly of half-desmosomal
structures in the absence of cell
contacts and their frustrated
endocytosis: a coordinated Sisyphus
cycle . . . . . . . . . . . . . . . . . 745
J. M. Rodier and
A. M. Vallés and
M. Denoyelle and
J. P. Thiery and
B. Boyer pp60c-src is a positive regulator of
growth factor-induced cell scattering in
a rat bladder carcinoma cell line . . . 761
C. A. Owen and
M. A. Campbell and
P. L. Sannes and
S. S. Boukedes and
E. J. Campbell Cell surface-bound elastase and
cathepsin G on human neutrophils: a
novel, non-oxidative mechanism by which
neutrophils focus and preserve catalytic
activity of serine proteinases . . . . . 775
S. Miyamoto and
H. Teramoto and
O. A. Coso and
J. S. Gutkind and
P. D. Burbelo and
S. K. Akiyama and
K. M. Yamada Integrin function: molecular hierarchies
of cytoskeletal and signaling molecules 791
S. J. Shattil and
T. O'Toole and
M. Eigenthaler and
V. Thon and
M. Williams and
B. M. Babior and
M. H. Ginsberg Beta $3$-endonexin, a novel polypeptide
that interacts specifically with the
cytoplasmic tail of the integrin beta 3
subunit . . . . . . . . . . . . . . . . 807
K. Bohmann and
J. A. Ferreira and
A. I. Lamond Mutational analysis of p80 coilin
indicates a functional interaction
between coiled bodies and the nucleolus 817
K. Afshar and
J. Scholey and
R. S. Hawley Identification of the chromosome
localization domain of the
\bionameDrosophila nod kinesin-like
protein . . . . . . . . . . . . . . . . 833
R. Dorer and
P. M. Pryciak and
L. H. Hartwell Saccharomyces cerevisiae cells execute a
default pathway to select a mate in the
absence of pheromone gradients . . . . . 845
N. Valtz and
M. Peter and
I. Herskowitz FAR1 is required for oriented
polarization of yeast cells in response
to mating pheromones . . . . . . . . . . 863
M. Aridor and
S. I. Bannykh and
T. Rowe and
W. E. Balch Sequential coupling between COPII and
COPI vesicle coats in endoplasmic
reticulum to Golgi transport . . . . . . 875
S. Schröder and
F. Schimmöller and
B. Singer-Krüger and
H. Riezman The Golgi-localization of yeast Emp47p
depends on its di-lysine motif but is
not affected by the ret1-1 mutation in
alpha--COP . . . . . . . . . . . . . . . 895
M. Lussier and
A. M. Sdicu and
T. Ketela and
H. Bussey Localization and targeting of the
\bionameSaccharomyces cerevisiae
Kre2p/Mnt1p alpha
1,2-mannosyltransferase to a media-Golgi
compartment . . . . . . . . . . . . . . 913
E. J. Smart and
Y. S. Ying and
R. G. Anderson Hormonal regulation of caveolae
internalization . . . . . . . . . . . . 929
E. M. Danielsen and
B. van Deurs A transferrin-like GPI-linked
iron-binding protein in
detergent-insoluble noncaveolar
microdomains at the apical surface of
fetal intestinal epithelial cells . . . 939
W. I. Lencer and
C. Constable and
S. Moe and
M. G. Jobling and
H. M. Webb and
S. Ruston and
J. L. Madara and
T. R. Hirst and
R. K. Holmes Targeting of cholera toxin and
\bionameEscherichia coli heat labile
toxin in polarized epithelia: role of
COOH-terminal KDEL . . . . . . . . . . . 951
I. Sase and
T. Okinaga and
M. Hoshi and
G. W. Feigenson and
K. Kinosita Regulatory mechanisms of the acrosome
reaction revealed by multiview
microscopy of single starfish sperm . . 963
J. T. Vilquin and
E. Wagner and
I. Kinoshita and
R. Roy and
J. P. Tremblay Successful histocompatible myoblast
transplantation in dystrophin-deficient
mdx mouse despite the production of
antibodies against dystrophin . . . . . 975
A. B. Verkhovsky and
T. M. Svitkina and
G. G. Borisy Myosin II filament assemblies in the
active lamella of fibroblasts: their
morphogenesis and role in the formation
of actin filament bundles . . . . . . . 989
M. Farkasovsky and
H. Küntzel Yeast Num1p associates with the mother
cell cortex during S/G2 phase and
affects microtubular functions . . . . . 1003
D. Masson and
T. E. Kreis Binding of E--MAP--115 to microtubules
is regulated by cell cycle-dependent
phosphorylation . . . . . . . . . . . . 1015
S. Loukin and
C. Kung Manganese effectively supports yeast
cell-cycle progression in place of
calcium . . . . . . . . . . . . . . . . 1025
T. Nakata and
N. Hirokawa Point mutation of adenosine
triphosphate-binding motif generated
rigor kinesin that selectively blocks
anterograde lysosome membrane transport 1039
M. Ogawara and
N. Inagaki and
K. Tsujimura and
Y. Takai and
M. Sekimata and
M. H. Ha and
S. Imajoh-Ohmi and
S. Hirai and
S. Ohno and
H. Sugiura Differential targeting of protein kinase
C and CaM kinase II signalings to
vimentin . . . . . . . . . . . . . . . . 1055
D. M. Suter and
G. E. Pollerberg and
A. Buchstaller and
R. J. Giger and
W. J. Dreyer and
P. Sonderegger Binding between the neural cell adhesion
molecules axonin-1 and Nr-CAM\slash
Bravo is involved in neuron-glia
interaction . . . . . . . . . . . . . . 1067
S. Arber and
P. Caroni Thrombospondin-4, an extracellular
matrix protein expressed in the
developing and adult nervous system
promotes neurite outgrowth . . . . . . . 1083
Z. Feng and
A. Marti and
B. Jehn and
H. J. Altermatt and
G. Chicaiza and
R. Jaggi Glucocorticoid and progesterone inhibit
involution and programmed cell death in
the mouse mammary gland . . . . . . . . 1095
L. Gnessi and
A. Emidi and
E. A. Jannini and
E. Carosa and
M. Maroder and
M. Arizzi and
S. Ulisse and
G. Spera Testicular development involves the
spatiotemporal control of PDGFs and PDGF
receptors gene expression and action . . 1105
D. Zhang and
R. B. Nicklas Chromosomes initiate spindle assembly
upon experimental dissolution of the
nuclear envelope in grasshopper
spermatocytes . . . . . . . . . . . . . 1125
J. D. Aitchison and
M. P. Rout and
M. Marelli and
G. Blobel and
R. W. Wozniak Two novel related yeast nucleoporins
Nup170p and Nup157p: complementation
with the vertebrate homologue Nup155p
and functional interactions with the
yeast nuclear pore-membrane protein
Pom152p . . . . . . . . . . . . . . . . 1133
K. I. Lin and
S. H. Lee and
R. Narayanan and
J. M. Baraban and
J. M. Hardwick and
R. R. Ratan Thiol agents and Bcl-2 identify an
alphavirus-induced apoptotic pathway
that requires activation of the
transcription factor NF-kappa B . . . . 1149
S. K. Lyman and
R. Schekman Interaction between BiP and Sec63p is
required for the completion of protein
translocation into the ER of
\bionameSaccharomyces cerevisiae . . . . 1163
D. Steverding and
Y. D. Stierhof and
H. Fuchs and
R. Tauber and
P. Overath Transferrin-binding protein complex is
the receptor for transferrin uptake in
Trypanosoma brucei . . . . . . . . . . . 1173
T. Whalley and
M. Terasaki and
M. S. Cho and
S. S. Vogel Direct membrane retrieval into large
vesicles after exocytosis in sea urchin
eggs . . . . . . . . . . . . . . . . . . 1183
D. W. Laird and
M. Castillo and
L. Kasprzak Gap junction turnover, intracellular
trafficking, and phosphorylation of
connexin43 in brefeldin A-treated rat
mammary tumor cells . . . . . . . . . . 1193
K. D. Novak and
M. D. Peterson and
M. C. Reedy and
M. A. Titus \bionameDictyostelium myosin I double
mutants exhibit conditional defects in
pinocytosis . . . . . . . . . . . . . . 1205
F. Castellino and
S. Ono and
F. Matsumura and
A. Luini Essential role of caldesmon in the actin
filament reorganization induced by
glucocorticoids . . . . . . . . . . . . 1223
M. Berryman and
R. Gary and
A. Bretscher Ezrin oligomers are major cytoskeletal
components of placental microvilli: a
proposal for their involvement in
cortical morphogenesis . . . . . . . . . 1231
K. C. Gunsalus and
S. Bonaccorsi and
E. Williams and
F. Verni and
M. Gatti and
M. L. Goldberg Mutations in twinstar, a
\bionameDrosophila gene encoding a
cofilin/ADF homologue, result in defects
in centrosome migration and cytokinesis 1243
K. Oegema and
W. G. Whitfield and
B. Alberts The cell cycle-dependent localization of
the CP190 centrosomal protein is
determined by the coordinate action of
two separable domains . . . . . . . . . 1261
G. Gurland and
G. G. Gundersen Stable, detyrosinated microtubules
function to localize vimentin
intermediate filaments in fibroblasts 1275
J. Liao and
L. A. Lowthert and
N. O. Ku and
R. Fernandez and
M. B. Omary Dynamics of human keratin 18
phosphorylation: polarized distribution
of phosphorylated keratins in simple
epithelial tissues . . . . . . . . . . . 1291
N. O. Ku and
S. Michie and
R. G. Oshima and
M. B. Omary Chronic hepatitis, hepatocyte fragility,
and increased soluble
phosphoglycokeratins in transgenic mice
expressing a keratin 18 conserved
arginine mutant . . . . . . . . . . . . 1303
R. L. Morris and
P. J. Hollenbeck Axonal transport of mitochondria along
microtubules and F-actin in living
vertebrate neurons . . . . . . . . . . . 1315
R. Brandt and
J. Léger and
G. Lee Interaction of tau with the neural
plasma membrane mediated by tau's
amino-terminal projection domain . . . . 1327
L. Adams and
B. M. Carlson and
L. Henderson and
D. Goldman Adaptation of nicotinic acetylcholine
receptor, myogenin, and MRF4 gene
expression to long-term muscle
denervation . . . . . . . . . . . . . . 1341
R. St-Arnaud and
J. Prud'homme and
C. Leung-Hagesteijn and
S. Dedhar Constitutive expression of calreticulin
in osteoblasts inhibits mineralization 1351
J. R. McIntosh and
R. R. West A cell biological perspective on genome
research . . . . . . . . . . . . . . . . 1361
J. Bednar and
R. A. Horowitz and
J. Dubochet and
C. L. Woodcock Chromatin conformation and salt-induced
compaction: three-dimensional structural
information from cryoelectron microscopy 1365
P. Mayinger and
V. A. Bankaitis and
D. I. Meyer Sac1p mediates the adenosine
triphosphate transport into yeast
endoplasmic reticulum that is required
for protein translocation . . . . . . . 1377
J. C. Stinchcombe and
H. Nomoto and
D. F. Cutler and
C. R. Hopkins Anterograde and retrograde traffic
between the rough endoplasmic reticulum
and the Golgi complex . . . . . . . . . 1387
G. Raposo and
H. M. van Santen and
R. Leijendekker and
H. J. Geuze and
H. L. Ploegh Misfolded major histocompatibility
complex class I molecules accumulate in
an expanded ER--Golgi intermediate
compartment . . . . . . . . . . . . . . 1403
P. A. Conrad and
E. J. Smart and
Y. S. Ying and
R. G. Anderson and
G. S. Bloom Caveolin cycles between plasma membrane
caveolae and the Golgi complex by
microtubule-dependent and
microtubule-independent steps . . . . . 1421
Y. Feng and
B. Press and
A. Wandinger-Ness Rab 7: an important regulator of late
endocytic membrane traffic . . . . . . . 1435
R. K. Szilard and
V. I. Titorenko and
M. Veenhuis and
R. A. Rachubinski Pay32p of the yeast Yarrowia lipolytica
is an intraperoxisomal component of the
matrix protein translocation machinery 1453
A. Houmeida and
J. Holt and
L. Tskhovrebova and
J. Trinick Studies of the interaction between titin
and myosin . . . . . . . . . . . . . . . 1471
T. S. Karpova and
K. Tatchell and
J. A. Cooper Actin filaments in yeast are unstable in
the absence of capping protein or
fimbrin . . . . . . . . . . . . . . . . 1483
D. C. Shutt and
D. Wessels and
K. Wagenknecht and
A. Chandrasekhar and
A. L. Hitt and
E. J. Luna and
D. R. Soll Ponticulin plays a role in the
positional stabilization of pseudopods 1495
K. T. Vaughan and
R. B. Vallee Cytoplasmic dynein binds dynactin
through a direct interaction between the
intermediate chains and p150Glued . . . 1507
K. G. Kozminski and
P. L. Beech and
J. L. Rosenbaum The Chlamydomonas kinesin-like protein
FLA10 is involved in motility associated
with the flagellar membrane . . . . . . 1517
F. Verde and
J. Mata and
P. Nurse Fission yeast cell morphogenesis:
identification of new genes and analysis
of their role during the cell cycle . . 1529
D. C. Chang and
C. Meng A localized elevation of cytosolic free
calcium is associated with cytokinesis
in the zebrafish embryo . . . . . . . . 1539
A. J. Denzer and
M. Gesemann and
B. Schumacher and
M. A. Ruegg An amino-terminal extension is required
for the secretion of chick agrin and its
binding to extracellular matrix . . . . 1547
C. Vozzi and
S. Ullrich and
A. Charollais and
J. Philippe and
L. Orci and
P. Meda Adequate connexin-mediated coupling is
required for proper insulin production 1561
V. Brinkmann and
H. Foroutan and
M. Sachs and
K. M. Weidner and
W. Birchmeier Hepatocyte growth factor/scatter factor
induces a variety of tissue-specific
morphogenic programs in epithelial cells 1573
J. Rak and
Y. Mitsuhashi and
V. Erdos and
S. N. Huang and
J. Filmus and
R. S. Kerbel Massive programmed cell death in
intestinal epithelial cells induced by
three-dimensional growth conditions:
suppression by mutant c--H--ras oncogene
expression . . . . . . . . . . . . . . . 1587
B. A. McCormick and
P. M. Hofman and
J. Kim and
D. K. Carnes and
S. I. Miller and
J. L. Madara Surface attachment of Salmonella
typhimurium to intestinal epithelia
imprints the subepithelial matrix with
gradients chemotactic for neutrophils 1599
M. Conese and
A. Nykjaer and
C. M. Petersen and
O. Cremona and
R. Pardi and
P. A. Andreasen and
J. Gliemann and
E. I. Christensen and
F. Blasi alpha-2 Macroglobulin receptor/Ldl
receptor-related protein(Lrp)-dependent
internalization of the urokinase
receptor . . . . . . . . . . . . . . . . 1609
K. L. Bennett and
B. Modrell and
B. Greenfield and
A. Bartolazzi and
I. Stamenkovic and
R. Peach and
D. G. Jackson and
F. Spring and
A. Aruffo Regulation of CD44 binding to hyaluronan
by glycosylation of variably spliced
exons . . . . . . . . . . . . . . . . . 1623
Y. Xing and
C. V. Johnson and
P. T. Moen and
J. A. McNeil and
J. Lawrence Nonrandom gene organization: structural
arrangements of specific pre-mRNA
transcription and splicing with SC-35
domains . . . . . . . . . . . . . . . . 1635
M. R. Jacobson and
L. G. Cao and
Y. L. Wang and
T. Pederson Dynamic localization of RNase MRP RNA in
the nucleolus observed by fluorescent
RNA cytochemistry in living cells . . . 1649
J. D. Aitchison and
G. Blobel and
M. P. Rout Nup120p: a yeast nucleoporin required
for NPC distribution and mRNA transport 1659
C. V. Heath and
C. S. Copeland and
D. C. Amberg and
V. Del Priore and
M. Snyder and
C. N. Cole Nuclear pore complex clustering and
nuclear accumulation of poly(A)+ RNA
associated with mutation of the
\bionameSaccharomyces cerevisiae
RAT2/NUP120 gene . . . . . . . . . . . . 1677
M. K. Iovine and
J. L. Watkins and
S. R. Wente The GLFG repetitive region of the
nucleoporin Nup116p interacts with
Kap95p, an essential yeast nuclear
import factor . . . . . . . . . . . . . 1699
N. Nakamura and
C. Rabouille and
R. Watson and
T. Nilsson and
N. Hui and
P. Slusarewicz and
T. E. Kreis and
G. Warren Characterization of a cis-Golgi matrix
protein, GM130 . . . . . . . . . . . . . 1715
S. V. Scott and
D. J. Klionsky In vitro reconstitution of cytoplasm to
vacuole protein targeting in yeast . . . 1727
K. Miyake and
P. L. McNeil Vesicle accumulation and exocytosis at
sites of plasma membrane disruption . . 1737
G. Q. Bi and
J. M. Alderton and
R. A. Steinhardt Calcium-regulated exocytosis is required
for cell membrane resealing . . . . . . 1747
P. von Arx and
S. Bantle and
T. Soldati and
J. C. Perriard Dominant negative effect of cytoplasmic
actin isoproteins on cardiomyocyte
cytoarchitecture and function . . . . . 1759
S. G. Sobel and
M. Snyder A highly divergent gamma-tubulin gene is
essential for cell growth and proper
microtubule organization in
\bionameSaccharomyces cerevisiae . . . . 1775
Y. Takei and
A. Harada and
S. Takeda and
K. Kobayashi and
S. Terada and
T. Noda and
T. Takahashi and
N. Hirokawa Synapsin I deficiency results in the
structural change in the presynaptic
terminals in the murine nervous system 1789
K. Stenius and
R. Janz and
T. C. Südhof and
R. Jahn Structure of synaptogyrin (p29) defines
novel synaptic vesicle protein . . . . . 1801
L. Bö and
R. H. Quarles and
N. Fujita and
Z. Bartoszewicz and
S. Sato and
B. D. Trapp Endocytic depletion of L--MAG from CNS
myelin in quaking mice . . . . . . . . . 1811
M. Kunimoto A neuron-specific isoform of brain
ankyrin, 440-kD ankyrinB, is targeted to
the axons of rat cerebellar neurons . . 1821
A. Benmerah and
J. Gagnon and
B. B\`egue and
B. Mégarbané and
A. Dautry-Varsat and
N. Cerf-Bensussan The tyrosine kinase substrate eps15 is
constitutively associated with the
plasma membrane adaptor AP-2 . . . . . . 1831
H. Takeda and
A. Nagafuchi and
S. Yonemura and
S. Tsukita and
J. Behrens and
W. Birchmeier and
S. Tsukita V-src kinase shifts the cadherin-based
cell adhesion from the strong to the
weak state and beta catenin is not
required for the shift . . . . . . . . . 1839
M. H. Driessens and
P. J. Stroeken and
N. F. Rodriguez Erena and
M. A. van der Valk and
E. A. van Rijthoven and
E. Roos Targeted disruption of CD44 in MDAY--D2
lymphosarcoma cells has no effect on
subcutaneous growth or metastatic
capacity . . . . . . . . . . . . . . . . 1849
N. A. Hotchin and
A. Hall The assembly of integrin adhesion
complexes requires both extracellular
matrix and intracellular rho/rac GTPases 1857
Y. Shimizu and
J. L. Mobley and
L. D. Finkelstein and
A. S. Chan A role for phosphatidylinositol
$3$-kinase in the regulation of beta 1
integrin activity by the CD2 antigen . . 1867
M. Ruppert and
S. Aigner and
M. Hubbe and
H. Yagita and
P. Altevogt The L1 adhesion molecule is a cellular
ligand for VLA-5 . . . . . . . . . . . . 1881
K. D. Patel and
M. U. Nollert and
R. P. McEver P-selectin must extend a sufficient
length from the plasma membrane to
mediate rolling of neutrophils . . . . . 1893
O. Langholz and
D. Röckel and
C. Mauch and
E. Kozlowska and
I. Bank and
T. Krieg and
B. Eckes Collagen and collagenase gene expression
in three-dimensional collagen lattices
are differentially regulated by alpha 1
beta 1 and alpha 2 beta 1 integrins . . 1903
S. A. Lewis and
G. Tian and
I. E. Vainberg and
N. J. Cowan Chaperonin-mediated folding of actin and
tubulin . . . . . . . . . . . . . . . . 1
C. Macaulay and
D. J. Forbes Assembly of the nuclear pore:
biochemically distinct steps revealed
with NEM, GTP gamma S, and BAPTA . . . . 5
W. Stoorvogel and
V. Oorschot and
H. J. Geuze A novel class of clathrin-coated
vesicles budding from endosomes . . . . 21
S. Rijnboutt and
G. Jansen and
G. Posthuma and
J. B. Hynes and
J. H. Schornagel and
G. J. Strous Endocytosis of GPI-linked membrane
folate receptor-alpha . . . . . . . . . 35
S. Zimmerli and
M. Majeed and
M. Gustavsson and
O. Stendahl and
D. A. Sanan and
J. D. Ernst Phagosome-lysosome fusion is a
calcium-independent event in macrophages 49
S. V. Scott and
S. M. Theg A new chloroplast protein import
intermediate reveals distinct
translocation machineries in the two
envelope membranes: energetics and
mechanistic implications . . . . . . . . 63
R. Prekeris and
M. W. Mayhew and
J. B. Cooper and
D. M. Terrian Identification and localization of an
actin-binding motif that is unique to
the epsilon isoform of protein kinase C
and participates in the regulation of
synaptic function . . . . . . . . . . . 77
M. Yasunaga and
T. Yagi and
N. Hanzawa and
M. Yasuda and
Y. Yamanashi and
T. Yamamoto and
S. Aizawa and
Y. Miyauchi and
S. Nishikawa Involvement of Fyn tyrosine kinase in
progression of cytokinesis of B
lymphocyte progenitor . . . . . . . . . 91
M. F. Kolman and
L. M. Futey and
T. T. Egelhoff \bionameDictyostelium myosin heavy chain
kinase A regulates myosin localization
during growth and development . . . . . 101
E. Weiss and
M. Winey The \bionameSaccharomyces cerevisiae
spindle pole body duplication gene MPS1
is part of a mitotic checkpoint . . . . 111
E. Okumura and
T. Sekiai and
S. Hisanaga and
K. Tachibana and
T. Kishimoto Initial triggering of M-phase in
starfish oocytes: a possible novel
component of maturation-promoting factor
besides cdc2 kinase . . . . . . . . . . 125
G. Mondésert and
S. I. Reed BED1, a gene encoding a
galactosyltransferase homologue, is
required for polarized growth and
efficient bud emergence in
\bionameSaccharomyces cerevisiae . . . . 137
J. B. Bachant and
M. W. Klymkowsky A nontetrameric species is the major
soluble form of keratin in
\bionameXenopus oocytes and rabbit
reticulocyte lysates . . . . . . . . . . 153
O. Rossetto and
L. Gorza and
G. Schiavo and
N. Schiavo and
R. H. Scheller and
C. Montecucco VAMP\slash synaptobrevin isoforms 1 and
2 are widely and differentially
expressed in nonneuronal tissues . . . . 167
S. Yoshida and
A. Fujisawa-Sehara and
T. Taki and
K. Arai and
Y. Nabeshima Lysophosphatidic acid and bFGF control
different modes in proliferating
myoblasts . . . . . . . . . . . . . . . 181
A. Erlebacher and
R. Derynck Increased expression of TGF-beta 2 in
osteoblasts results in an
osteoporosis-like phenotype . . . . . . 195
A. M. Belkin and
N. I. Zhidkova and
F. Balzac and
F. Altruda and
D. Tomatis and
A. Maier and
G. Tarone and
V. E. Koteliansky and
K. Burridge Beta $1$D integrin displaces the beta 1A
isoform in striated muscles:
localization at junctional structures
and signaling potential in nonmuscle
cells . . . . . . . . . . . . . . . . . 211
K. Wennerberg and
L. Lohikangas and
D. Gullberg and
M. Pfaff and
S. Johansson and
R. Fässler Beta 1 integrin-dependent and
-independent polymerization of
fibronectin . . . . . . . . . . . . . . 227
J. Xu and
R. A. Clark Extracellular matrix alters PDGF
regulation of fibroblast integrins . . . 239
S. A. Hayes and
J. F. Dice Roles of molecular chaperones in protein
degradation . . . . . . . . . . . . . . 255
C. M. Clemson and
J. A. McNeil and
H. F. Willard and
J. B. Lawrence XIST RNA paints the inactive X
chromosome at interphase: evidence for a
novel RNA involved in nuclear/chromosome
structure . . . . . . . . . . . . . . . 259
V. V. Lupashin and
S. Hamamoto and
R. W. Schekman Biochemical requirements for the
targeting and fusion of ER-derived
transport vesicles with purified yeast
Golgi membranes . . . . . . . . . . . . 277
A. A. McCracken and
J. L. Brodsky Assembly of ER-associated protein
degradation in vitro: dependence on
cytosol, calnexin, and ATP . . . . . . . 291
J. Dietrich and
A. Neisig and
X. Hou and
A. M. Wegener and
M. Gajhede and
C. Geisler Role of CD3 gamma in T cell receptor
assembly . . . . . . . . . . . . . . . . 299
T. Häusler and
Y. D. Stierhof and
E. Wirtz and
C. Clayton Import of a DHFR hybrid protein into
glycosomes in vivo is not inhibited by
the folate-analogue aminopterin . . . . 311
J. W. Zhang and
P. B. Lazarow Peb1p (Pas7p) is an intraperoxisomal
receptor for the NH2-terminal, type 2,
peroxisomal targeting sequence of
thiolase: Peb1p itself is targeted to
peroxisomes by an NH2-terminal peptide 325
H. Aizawa and
K. Sutoh and
I. Yahara Overexpression of cofilin stimulates
bundling of actin filaments, membrane
ruffling, and cell movement in
\bionameDictyostelium . . . . . . . . . 335
X. M. Wang and
J. G. Peloquin and
Y. Zhai and
J. C. Bulinski and
G. G. Borisy Removal of MAP4 from microtubules in
vivo produces no observable phenotype at
the cellular level . . . . . . . . . . . 345
E. F. Smith and
P. A. Lefebvre PF16 encodes a protein with armadillo
repeats and localizes to a single
microtubule of the central apparatus in
Chlamydomonas flagella . . . . . . . . . 359
K. P. Wedaman and
D. W. Meyer and
D. J. Rashid and
D. G. Cole and
J. M. Scholey Sequence and submolecular localization
of the 115-kD accessory subunit of the
heterotrimeric kinesin-II (KRP85/95)
complex . . . . . . . . . . . . . . . . 371
R. D. Paladini and
K. Takahashi and
N. S. Bravo and
P. A. Coulombe Onset of re-epithelialization after skin
injury correlates with a reorganization
of keratin filaments in wound edge
keratinocytes: defining a potential role
for keratin 16 . . . . . . . . . . . . . 381
H. Fares and
L. Goetsch and
J. R. Pringle Identification of a developmentally
regulated septin and involvement of the
septins in spore formation in
\bionameSaccharomyces cerevisiae . . . . 399
I. Vincent and
M. Rosado and
P. Davies Mitotic mechanisms in Alzheimer's
disease? . . . . . . . . . . . . . . . . 413
N. Cabrera and
E. Díaz-Rodríguez and
E. Becker and
D. Martín-Zanca and
A. Pandiella TrkA receptor ectodomain cleavage
generates a tyrosine-phosphorylated
cell-associated fragment . . . . . . . . 427
C. A. Parkos and
S. P. Colgan and
T. W. Liang and
A. Nusrat and
A. E. Bacarra and
D. K. Carnes and
J. L. Madara CD47 mediates post-adhesive events
required for neutrophil migration across
polarized intestinal epithelia . . . . . 437
A. K. Rajasekaran and
M. Hojo and
T. Huima and
E. Rodriguez-Boulan Catenins and zonula occludens-1 form a
complex during early stages in the
assembly of tight junctions . . . . . . 451
M. L. Dustin and
L. M. Ferguson and
P. Y. Chan and
T. A. Springer and
D. E. Golan Visualization of CD2 interaction with
LFA-3 and determination of the
two-dimensional dissociation constant
for adhesion receptors in a contact area 465
A. M. Montgomery and
J. C. Becker and
C. H. Siu and
V. P. Lemmon and
D. A. Cheresh and
J. D. Pancook and
X. Zhao and
R. A. Reisfeld Human neural cell adhesion molecule L1
and rat homologue NILE are ligands for
integrin alpha v beta 3 . . . . . . . . 475
G. Mertens and
B. Van der Schueren and
H. van den Berghe and
G. David Heparan sulfate expression in polarized
epithelial cells: the apical sorting of
glypican (GPI-anchored proteoglycan) is
inversely related to its heparan sulfate
content . . . . . . . . . . . . . . . . 487
D. T. Ng and
P. Walter ER membrane protein complex required for
nuclear fusion . . . . . . . . . . . . . 499
H. L. Pahl and
M. Sester and
H. G. Burgert and
P. A. Baeuerle Activation of transcription factor
NF-kappaB by the adenovirus E3/19K
protein requires its ER retention . . . 511
A. S. Dittie and
N. Hajibagheri and
S. A. Tooze The AP-1 adaptor complex binds to
immature secretory granules from PC12
cells, and is regulated by
ADP-ribosylation factor . . . . . . . . 523
E. Grote and
R. B. Kelly Endocytosis of VAMP is facilitated by a
synaptic vesicle targeting signal . . . 537
E. E. Swartzman and
M. N. Viswanathan and
J. Thorner The PAL1 gene product is a peroxisomal
ATP-binding cassette transporter in the
yeast \bionameSaccharomyces cerevisiae 549
J. Rohrer and
A. Schweizer and
D. Russell and
S. Kornfeld The targeting of Lamp1 to lysosomes is
dependent on the spacing of its
cytoplasmic tail tyrosine sorting motif
relative to the membrane . . . . . . . . 565
A. Schweizer and
S. Kornfeld and
J. Rohrer Cysteine34 of the cytoplasmic tail of
the cation-dependent mannose
$6$-phosphate receptor is reversibly
palmitoylated and required for normal
trafficking and lysosomal enzyme sorting 577
Y. K. Oh and
J. A. Swanson Different fates of phagocytosed
particles after delivery into macrophage
lysosomes . . . . . . . . . . . . . . . 585
H. Shpetner and
M. Joly and
D. Hartley and
S. Corvera Potential sites of PI-3 kinase function
in the endocytic pathway revealed by the
PI-3 kinase inhibitor, wortmannin . . . 595
A. Tanimura and
R. J. Turner Calcium release in HSY cells conforms to
a steady-state mechanism involving
regulation of the inositol
1,4,5-trisphosphate receptor Ca$^{2+}$
channel by luminal [Ca$^{2+}$] . . . . . 607
C. J. Echeverri and
B. M. Paschal and
K. T. Vaughan and
R. B. Vallee Molecular characterization of the 50-kD
subunit of dynactin reveals function for
the complex in chromosome alignment and
spindle organization during mitosis . . 617
M. Sekimata and
K. Tsujimura and
J. Tanaka and
Y. Takeuchi and
N. Inagaki and
M. Inagaki Detection of protein kinase activity
specifically activated at
metaphase-anaphase transition . . . . . 635
G. Goulielmos and
F. Gounari and
S. Remington and
S. Müller and
M. Häner and
U. Aebi and
S. D. Georgatos Filensin and phakinin form a novel type
of beaded intermediate filaments and
coassemble de novo in cultured cells . . 643
V. Andrés and
K. Walsh Myogenin expression, cell cycle
withdrawal, and phenotypic
differentiation are temporally separable
events that precede cell fusion upon
myogenesis . . . . . . . . . . . . . . . 657
N. Hirokawa and
T. Funakoshi and
R. Sato-Harada and
Y. Kanai Selective stabilization of tau in axons
and microtubule-associated protein 2C in
cell bodies and dendrites contributes to
polarized localization of cytoskeletal
proteins in mature neurons . . . . . . . 667
B. Götz and
A. Scholze and
A. Clement and
A. Joester and
K. Schütte and
F. Wigger and
R. Frank and
E. Spiess and
P. Ekblom and
A. Faissner Tenascin-C contains distinct adhesive,
anti-adhesive, and neurite outgrowth
promoting sites for neurons . . . . . . 681
I. Dunia and
J. J. Smit and
M. A. van der Valk and
H. Bloemendal and
P. Borst and
E. L. Benedetti Human multidrug resistance
3-P-glycoprotein expression in
transgenic mice induces lens membrane
alterations leading to cataract . . . . 701
G. Weskamp and
J. Krätzschmar and
M. S. Reid and
C. P. Blobel MDC9, a widely expressed cellular
disintegrin containing cytoplasmic SH3
ligand domains . . . . . . . . . . . . . 717
Y. Xia and
S. G. Gil and
W. G. Carter Anchorage mediated by integrin
alpha6beta4 to laminin 5 (epiligrin)
regulates tyrosine phosphorylation of a
membrane-associated 80-kD protein . . . 727
C. Sundberg and
K. Rubin Stimulation of beta1 integrins on
fibroblasts induces PDGF independent
tyrosine phosphorylation of PDGF
beta-receptors . . . . . . . . . . . . . 741
S. K. Sapperstein and
V. V. Lupashin and
H. D. Schmitt and
M. G. Waters Assembly of the ER to Golgi SNARE
complex requires Uso1p . . . . . . . . . 755
J. N. Glickman and
P. A. Morton and
J. W. Slot and
S. Kornfeld and
H. J. Geuze The biogenesis of the MHC class II
compartment in human I-cell disease B
lymphoblasts . . . . . . . . . . . . . . 769
Z. Xu and
W. Wickner Thioredoxin is required for vacuole
inheritance in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 787
M. M. Sauter and
A. Pelchen-Matthews and
R. Bron and
M. Marsh and
C. C. LaBranche and
P. J. Vance and
J. Romano and
B. S. Haggarty and
T. K. Hart and
W. M. Lee and
J. A. Hoxie An internalization signal in the simian
immunodeficiency virus transmembrane
protein cytoplasmic domain modulates
expression of envelope glycoproteins on
the cell surface . . . . . . . . . . . . 795
P. van der Bijl and
M. Lopes-Cardozo and
G. van Meer Sorting of newly synthesized
galactosphingolipids to the two surface
domains of epithelial cells . . . . . . 813
K. M. Marr and
D. N. Mastronarde and
M. K. Lyon Two-dimensional crystals of photosystem
II: biochemical characterization,
cryoelectron microscopy and localization
of the D1 and cytochrome b559
polypeptides . . . . . . . . . . . . . . 823
G. M. Benian and
T. L. Tinley and
X. Tang and
M. Borodovsky The \bionameCaenorhabditis elegans gene
unc-89, required fpr muscle M-line
assembly, encodes a giant modular
protein composed of Ig and signal
transduction domains . . . . . . . . . . 835
L. Li and
J. M. Miano and
B. Mercer and
E. N. Olson Expression of the SM22alpha promoter in
transgenic mice provides evidence for
distinct transcriptional regulatory
programs in vascular and visceral smooth
muscle cells . . . . . . . . . . . . . . 849
J. A. Waddle and
T. S. Karpova and
R. H. Waterston and
J. A. Cooper Movement of cortical actin patches in
yeast . . . . . . . . . . . . . . . . . 861
H. Abe and
T. Obinata and
L. S. Minamide and
J. R. Bamburg \bionameXenopus laevis
actin-depolymerizing factor/cofilin: a
phosphorylation-regulated protein
essential for development . . . . . . . 871
A. D. Donaldson and
J. V. Kilmartin Spc42p: a phosphorylated component of
the S. cerevisiae spindle pole body
(SPD) with an essential function during
SPB duplication . . . . . . . . . . . . 887
D. B. Friedman and
H. A. Sundberg and
E. Y. Huang and
T. N. Davis The 110-kD spindle pole body component
of \bionameSaccharomyces cerevisiae is a
phosphoprotein that is modified in a
cell cycle-dependent manner . . . . . . 903
T. Kono and
K. T. Jones and
A. Bos-Mikich and
D. G. Whittingham and
J. Carroll A cell cycle-associated change in
Ca$^{2+}$ releasing activity leads to
the generation of Ca$^{2+}$ transients
in mouse embryos during the first
mitotic division . . . . . . . . . . . . 915
R. M. Porter and
S. Leitgeb and
D. W. Melton and
O. Swensson and
R. A. Eady and
T. M. Magin Gene targeting at the mouse cytokeratin
10 locus: severe skin fragility and
changes of cytokeratin expression in the
epidermis . . . . . . . . . . . . . . . 925
M. Ferns and
M. Deiner and
Z. Hall Agrin-induced acetylcholine receptor
clustering in mammalian muscle requires
tyrosine phosphorylation . . . . . . . . 937
A. H. Ross and
M. C. Daou and
C. A. McKinnon and
P. J. Condon and
M. B. Lachyankar and
R. M. Stephens and
D. R. Kaplan and
D. E. Wolf The neurotrophin receptor, gp75, forms a
complex with the receptor tyrosine
kinase TrkA . . . . . . . . . . . . . . 945
H. Okazawa and
J. Shimizu and
M. Kamei and
I. Imafuku and
H. Hamada and
I. Kanazawa Bcl-2 inhibits retinoic acid-induced
apoptosis during the neural
differentiation of embryonal stem cells 955
V. F. Rafuse and
L. Landmesser Contractile activity regulates isoform
expression and polysialylation of NCAM
in cultured myotubes: involvement of
Ca$^{2+}$ and protein kinase C . . . . . 969
S. L. Harris and
M. G. Waters Localization of a yeast early Golgi
mannosyltransferase, Och1p, involves
retrograde transport . . . . . . . . . . 985
M. N. Oda and
S. V. Scott and
A. Hefner-Gravink and
A. D. Caffarelli and
D. J. Klionsky Identification of a cytoplasm to vacuole
targeting determinant in aminopeptidase
I . . . . . . . . . . . . . . . . . . . 999
C. E. Futter and
A. Pearse and
L. J. Hewlett and
C. R. Hopkins Multivesicular endosomes containing
internalized EGF--EGF receptor complexes
mature and then fuse directly with
lysosomes . . . . . . . . . . . . . . . 1011
F. Santini and
J. H. Keen Endocytosis of activated receptors and
clathrin-coated pit formation:
deciphering the chicken or egg
relationship . . . . . . . . . . . . . . 1025
T. Fukushima and
T. K. Waddell and
S. Grinstein and
G. G. Goss and
J. Orlowski and
G. P. Downey Na$^+$ /H$^+$ exchange activity during
phagocytosis in human neutrophils: role
of Fcgamma receptors and tyrosine
kinases . . . . . . . . . . . . . . . . 1037
E. M. Ostap and
T. D. Pollard Biochemical kinetic characterization of
the Acanthamoeba myosin--I ATPase . . . 1053
C. D. Myers and
P. Y. Goh and
T. S. Allen and
E. A. Bucher and
T. Bogaert Developmental genetic analysis of
troponin T mutations in striated and
nonstriated muscle cells of
\bionameCaenorhabditis elegans . . . . . 1061
C. E. Creutz and
S. L. Snyder and
S. N. Daigle and
J. Redick Identification, localization, and
functional implications of an abundant
nematode annexin . . . . . . . . . . . . 1079
A. Khodjakov and
R. W. Cole and
A. S. Bajer and
C. L. Rieder The force for poleward chromosome motion
in Haemanthus cells acts along the
length of the chromosome during
metaphase but only at the kinetochore
during anaphase . . . . . . . . . . . . 1093
F. Fagotto and
N. Funayama and
U. Gluck and
B. M. Gumbiner Binding to cadherins antagonizes the
signaling activity of beta-catenin
during axis formation in \bionameXenopus 1105
I. Fialka and
H. Schwarz and
E. Reichmann and
M. Oft and
M. Busslinger and
H. Beug The estrogen-dependent c--JunER protein
causes a reversible loss of mammary
epithelial cell polarity involving a
destabilization of adherens junctions 1115
G. D. Block and
J. Locker and
W. C. Bowen and
B. E. Petersen and
S. Katyal and
S. C. Strom and
T. Riley and
T. A. Howard and
G. K. Michalopoulos Population expansion, clonal growth, and
specific differentiation patterns in
primary cultures of hepatocytes induced
by HGF/SF, EGF and TGF alpha in a
chemically defined (HGM) medium . . . . 1133
K. Hannon and
A. J. Kudla and
M. J. McAvoy and
K. L. Clase and
B. B. Olwin Differentially expressed fibroblast
growth factors regulate skeletal muscle
development through autocrine and
paracrine mechanisms . . . . . . . . . . 1151
J. Wada and
A. Kumar and
Z. Liu and
E. Ruoslahti and
L. Reichardt and
J. Marvaldi and
Y. S. Kanwar Cloning of mouse integrin alphaV cDNA
and role of the alphaV-related matrix
receptors in metanephric development . . 1161
P. Koolwijk and
M. G. van Erck and
W. J. de Vree and
M. A. Vermeer and
H. A. Weich and
R. Hanemaaijer and
V. W. van Hinsbergh Cooperative effect of TNFalpha, bFGF,
and VEGF on the formation of tubular
structures of human microvascular
endothelial cells in a fibrin matrix.
Role of urokinase activity . . . . . . . 1177
M. F. Champliaud and
G. P. Lunstrum and
P. Rousselle and
T. Nishiyama and
D. R. Keene and
R. E. Burgeson Human amnion contains a novel laminin
variant, laminin 7, which like laminin
6, covalently associates with laminin 5
to promote stable epithelial-stromal
attachment . . . . . . . . . . . . . . . 1189
A. Bartolazzi and
A. Nocks and
A. Aruffo and
F. Spring and
I. Stamenkovic Glycosylation of CD44 is implicated in
CD44-mediated cell adhesion to
hyaluronan . . . . . . . . . . . . . . . 1199
C. S. Lebakken and
A. C. Rapraeger Syndecan-1 mediates cell spreading in
transfected human lymphoblastoid (Raji)
cells . . . . . . . . . . . . . . . . . 1209
J. M. Scholey Kinesin-II, a membrane traffic motor in
axons, axonemes, and spindles . . . . . 1
N. Visa and
E. Izaurralde and
J. Ferreira and
B. Daneholt and
I. W. Mattaj A nuclear cap-binding complex binds
Balbiani ring pre-mRNA
cotranscriptionally and accompanies the
ribonucleoprotein particle during
nuclear export . . . . . . . . . . . . . 5
K. N. Burger and
P. van der Bijl and
G. van Meer Topology of sphingolipid
galactosyltransferases in ER and Golgi:
transbilayer movement of monohexosyl
sphingolipids is required for higher
glycosphingolipid biosynthesis . . . . . 15
F. Aniento and
F. Gu and
R. G. Parton and
J. Gruenberg An endosomal beta COP is involved in the
pH-dependent formation of transport
vesicles destined for late endosomes . . 29
Y. Ando-Akatsuka and
M. Saitou and
T. Hirase and
M. Kishi and
A. Sakakibara and
M. Itoh and
S. Yonemura and
M. Furuse and
S. Tsukita Interspecies diversity of the occludin
sequence: cDNA cloning of human, mouse,
dog, and rat-kangaroo homologues . . . . 43
W. L. Zeile and
D. L. Purich and
F. S. Southwick Recognition of two classes of
oligoproline sequences in
profilin-mediated acceleration of
actin-based Shigella motility . . . . . 49
L. G. Tilney and
M. S. Tilney and
G. M. Guild Formation of actin filament bundles in
the ring canals of developing
\bionameDrosophila follicles . . . . . . 61
W. A. Wells and
A. W. Murray Aberrantly segregating centromeres
activate the spindle assembly checkpoint
in budding yeast . . . . . . . . . . . . 75
A. Yamamoto and
V. Guacci and
D. Koshland Pds1p is required for faithful execution
of anaphase in the yeast,
\bionameSaccharomyces cerevisiae . . . . 85
A. Yamamoto and
V. Guacci and
D. Koshland Pds1p, an inhibitor of anaphase in
budding yeast, plays a critical role in
the APC and checkpoint pathway(s) . . . 99
H. A. Sundberg and
L. Goetsch and
B. Byers and
T. N. Davis Role of calmodulin and Spc110p
interaction in the proper assembly of
spindle pole body compenents . . . . . . 111
M. Dogterom and
M. A. Félix and
C. C. Guet and
S. Leibler Influence of M-phase chromatin on the
anisotropy of microtubule asters . . . . 125
Y. Takai and
M. Ogawara and
Y. Tomono and
C. Moritoh and
S. Imajoh-Ohmi and
O. Tsutsumi and
Y. Taketani and
M. Inagaki Mitosis-specific phosphorylation of
vimentin by protein kinase C coupled
with reorganization of intracellular
membranes . . . . . . . . . . . . . . . 141
W. Yu and
M. J. Schwei and
P. W. Baas Microtubule transport and assembly
during axon growth . . . . . . . . . . . 151
A. Saada and
F. Reichert and
S. Rotshenker Granulocyte macrophage colony
stimulating factor produced in lesioned
peripheral nerves induces the
up-regulation of cell surface expression
of MAC-2 by macrophages and Schwann
cells . . . . . . . . . . . . . . . . . 159
S. K. Sastry and
M. Lakonishok and
D. A. Thomas and
J. Muschler and
A. F. Horwitz Integrin alpha subunit ratios,
cytoplasmic domains, and growth factor
synergy regulate muscle proliferation
and differentiation . . . . . . . . . . 169
J. T. Vilquin and
I. Kinoshita and
B. Roy and
M. Goulet and
E. Engvall and
F. Tomé and
M. Fardeau and
J. P. Tremblay Partial laminin alpha2 chain restoration
in alpha2 chain-deficient dy/dy mouse by
primary muscle cell culture
transplantation . . . . . . . . . . . . 185
I. Simcha and
B. Geiger and
S. Yehuda-Levenberg and
D. Salomon and
A. Ben-Ze'ev Suppression of tumorigenicity by
plakoglobin: an augmenting effect of
N-cadherin . . . . . . . . . . . . . . . 199
R. P. Huang and
J. X. Wu and
Y. Fan and
E. D. Adamson UV activates growth factor receptors via
reactive oxygen intermediates . . . . . 211
E. M. Ostap and
T. D. Pollard Overlapping functions of myosin--I
isoforms? . . . . . . . . . . . . . . . 221
P. Jordan and
M. Mannervik and
L. Tora and
M. Carmo-Fonseca In vivo evidence that TATA-binding
protein/SL1 colocalizes with UBF and RNA
polymerase I when rRNA synthesis is
either active or inactive . . . . . . . 225
P. Roussel and
C. André and
L. Comai and
D. Hernandez-Verdun The rDNA transcription machinery is
assembled during mitosis in active NORs
and absent in inactive NORs . . . . . . 235
T. Yoshimori and
P. Keller and
M. G. Roth and
K. Simons Different biosynthetic transport routes
to the plasma membrane in BHK and CHO
cells . . . . . . . . . . . . . . . . . 247
P. E. Scherer and
G. Z. Lederkremer and
S. Williams and
M. Fogliano and
G. Baldini and
H. F. Lodish Cab45, a novel (Ca$^{2+}$)-binding
protein localized to the Golgi lumen . . 257
J. M. Dyer and
J. A. McNew and
J. M. Goodman The sorting sequence of the peroxisomal
integral membrane protein PMP47 is
contained within a short hydrophilic
loop . . . . . . . . . . . . . . . . . . 269
P. A. Warmerdam and
E. O. Long and
P. A. Roche Isoforms of the invariant chain regulate
transport of MHC class II molecules to
antigen processing compartments . . . . 281
J. R. Sevinsky and
L. V. Rao and
W. Ruf Ligand-induced protease receptor
translocation into caveolae: a mechanism
for regulating cell surface proteolysis
of the tissue factor-dependent
coagulation pathway . . . . . . . . . . 293
G. Jung and
X. Wu and
J. A. Hammer \bionameDictyostelium mutants lacking
multiple classic myosin I isoforms
reveal combinations of shared and
distinct functions . . . . . . . . . . . 305
Y. Liu and
R. N. Kitsis Induction of DNA synthesis and apoptosis
in cardiac myocytes by E1A oncoprotein 325
L. E. French and
M. Hahne and
I. Viard and
G. Radlgruber and
R. Zanone and
K. Becker and
C. Müller and
J. Tschopp Fas and Fas ligand in embryos and adult
mice: ligand expression in several
immune-privileged tissues and
coexpression in adult tissues
characterized by apoptotic cell turnover 335
J. Liao and
M. B. Omary 14-3-3 proteins associate with
phosphorylated simple epithelial
keratins during cell cycle progression
and act as a solubility cofactor . . . . 345
N. A. Chitaev and
R. E. Leube and
R. B. Troyanovsky and
L. G. Eshkind and
W. W. Franke and
S. M. Troyanovsky The binding of plakoglobin to desmosomal
cadherins: patterns of binding sites and
topogenic potential . . . . . . . . . . 359
G. Piperno and
K. Mead and
S. Henderson Inner dynein arms but not outer dynein
arms require the activity of kinesin
homologue protein KHP1(FLA10) to reach
the distal part of flagella in
Chlamydomonas . . . . . . . . . . . . . 371
R. Ramanathan and
M. F. Wilkemeyer and
B. Mittal and
G. Perides and
M. E. Charness Alcohol inhibits cell--cell adhesion
mediated by human L1 . . . . . . . . . . 381
X. Zhu and
M. Ohtsubo and
R. M. Böhmer and
J. M. Roberts and
R. K. Assoian Adhesion-dependent cell cycle
progression linked to the expression of
cyclin D1, activation of cyclin E-cdk2,
and phosphorylation of the
retinoblastoma protein . . . . . . . . . 391
R. Steinfeld and
H. Van Den Berghe and
G. David Stimulation of fibroblast growth factor
receptor-1 occupancy and signaling by
cell surface-associated syndecans and
glypican . . . . . . . . . . . . . . . . 405
A. De Arcangelis and
P. Neuville and
R. Boukamel and
O. Lefebvre and
M. Kedinger and
P. Simon-Assmann Inhibition of laminin alpha $1$-chain
expression leads to alteration of
basement membrane assembly and cell
differentiation . . . . . . . . . . . . 417
D. C. Hocking and
R. K. Smith and
P. J. McKeown-Longo A novel role for the integrin-binding
III-10 module in fibronectin matrix
assembly . . . . . . . . . . . . . . . . 431
M. Yoshida and
W. F. Westlin and
N. Wang and
D. E. Ingber and
A. Rosenzweig and
N. Resnick and
M. A. Gimbrone Leukocyte adhesion to vascular
endothelium induces E-selectin linkage
to the actin cytoskeleton . . . . . . . 445
C. Shukunami and
C. Shigeno and
T. Atsumi and
K. Ishizeki and
F. Suzuki and
Y. Hiraki Chondrogenic differentiation of clonal
mouse embryonic cell line ATDC5 in
vitro: differentiation-dependent gene
expression of parathyroid hormone
(PTH)/PTH-related peptide receptor . . . 457
M. Satoh and
K. Hirayoshi and
S. Yokota and
N. Hosokawa and
K. Nagata Intracellular interaction of
collagen-specific stress protein HSP47
with newly synthesized procollagen . . . 469
I. Palacios and
K. Weis and
C. Klebe and
I. W. Mattaj and
C. Dingwall RAN\slash TC4 mutants identify a common
requirement for snRNP and protein import
into the nucleus . . . . . . . . . . . . 485
A. Verschoor and
S. Srivastava and
R. Grassucci and
J. Frank Native $3$D structure of eukaryotic 80s
ribosome: morphological homology with
\bionameE. coli 70S ribosome . . . . . . 495
M. Nagahama and
L. Orci and
M. Ravazzola and
M. Amherdt and
L. Lacomis and
P. Tempst and
J. E. Rothman and
T. H. Söllner A v--SNARE implicated in intra-Golgi
transport . . . . . . . . . . . . . . . 507
P. S. Kim and
O. Y. Kwon and
P. Arvan An endoplasmic reticulum storage disease
causing congenital goiter with
hypothyroidism . . . . . . . . . . . . . 517
A. A. Cooper and
T. H. Stevens Vps10p cycles between the late-Golgi and
prevacuolar compartments in its function
as the sorting receptor for multiple
yeast vacuolar hydrolases . . . . . . . 529
A. Müsch and
H. Xu and
D. Shields and
E. Rodriguez-Boulan Transport of vesicular stomatitis virus
G protein to the cell surface is signal
mediated in polarized and nonpolarized
cells . . . . . . . . . . . . . . . . . 543
T. Danieli and
S. L. Pelletier and
Y. I. Henis and
J. M. White Membrane fusion mediated by the
influenza virus hemagglutinin requires
the concerted action of at least three
hemagglutinin trimers . . . . . . . . . 559
J. P. Schroeter and
J. P. Bretaudiere and
R. L. Sass and
M. A. Goldstein Three-dimensional structure of the Z
band in a normal mammalian skeletal
muscle . . . . . . . . . . . . . . . . . 571
J. Niclas and
V. J. Allan and
R. D. Vale Cell cycle regulation of dynein
association with membranes modulates
microtubule-based organelle transport 585
H. Wein and
M. Foss and
B. Brady and
W. Z. Cande DSK1, a novel kinesin-related protein
from the diatom Cylindrotheca fusiformis
that is involved in anaphase spindle
elongation . . . . . . . . . . . . . . . 595
C. M. Field and
O. al-Awar and
J. Rosenblatt and
M. L. Wong and
B. Alberts and
T. J. Mitchison A purified \bionameDrosophila septin
complex forms filaments and exhibits
GTPase activity . . . . . . . . . . . . 605
A. M. Murphy and
D. J. Montell Cell type-specific roles for Cdc42, Rac,
and RhoL in \bionameDrosophila oogenesis 617
I. Neveu and
E. Arenas Neurotrophins promote the survival and
development of neurons in the cerebellum
of hypothyroid rats in vivo . . . . . . 631
R. R. Dubreuil and
G. MacVicar and
S. Dissanayake and
C. Liu and
D. Homer and
M. Hortsch Neuroglian-mediated cell adhesion
induces assembly of the membrane
skeleton at cell contact sites . . . . . 647
A. P. DeBernardo and
S. Chang Heterophilic interactions of DM--GRASP:
GRASP--NgCAM interactions involved in
neurite extension . . . . . . . . . . . 657
Y. Kanai and
M. Kanai-Azuma and
T. Noce and
T. C. Saido and
T. Shiroishi and
Y. Hayashi and
K. Yazaki Identification of two Sox17 messenger
RNA isoforms, with and without the high
mobility group box region, and their
differential expression in mouse
spermatogenesis . . . . . . . . . . . . 667
P. L. James and
C. E. Stewart and
P. Rotwein Insulin-like growth factor binding
protein-5 modulates muscle
differentiation through an insulin-like
growth factor-dependent mechanism . . . 683
G. M. Zinkl and
A. Zuk and
P. van der Bijl and
G. van Meer and
K. S. Matlin An antiglycolipid antibody inhibits
Madin--Darby canine kidney cell adhesion
to laminin and interferes with
basolateral polarization and tight
junction formation . . . . . . . . . . . 695
R. H. Schwall and
L. Y. Chang and
P. J. Godowski and
D. W. Kahn and
K. J. Hillan and
K. D. Bauer and
T. F. Zioncheck Heparin induces dimerization and confers
proliferative activity onto the
hepatocyte growth factor antagonists NK1
and NK2 . . . . . . . . . . . . . . . . 709
S. Huang and
D. L. Spector Intron-dependent recruitment of pre-mRNA
splicing factors to sites of
transcription . . . . . . . . . . . . . 719
T. Sakaguchi and
G. P. Leser and
R. A. Lamb The ion channel activity of the
influenza virus M2 protein affects
transport through the Golgi apparatus 733
F. Simpson and
N. A. Bright and
M. A. West and
L. S. Newman and
R. B. Darnell and
M. S. Robinson A novel adaptor-related protein complex 749
J. R. Henley and
M. A. McNiven Association of a dynamin-like protein
with the Golgi apparatus in mammalian
cells . . . . . . . . . . . . . . . . . 761
I. V. Majoul and
P. I. Bastiaens and
H. D. Söling Transport of an external
Lys--Asp--Glu--Leu (KDEL) protein from
the plasma membrane to the endoplasmic
reticulum: studies with cholera toxin in
Vero cells . . . . . . . . . . . . . . . 777
M. Deckert and
M. Ticchioni and
A. Bernard Endocytosis of GPI-anchored proteins in
human lymphocytes: role of
glycolipid-based domains, actin
cytoskeleton, and protein kinases . . . 791
P. Lupetti and
J. E. Heuser and
R. Manetti and
P. Massari and
S. Lanzavecchia and
P. L. Bellon and
R. Dallai and
R. Rappuoli and
J. L. Telford Oligomeric and subunit structure of the
Helicobacter pylori vacuolating
cytotoxin . . . . . . . . . . . . . . . 801
G. W. Moy and
L. M. Mendoza and
J. R. Schulz and
W. J. Swanson and
C. G. Glabe and
V. D. Vacquier The sea urchin sperm receptor for egg
jelly is a modular protein with
extensive homology to the human
polycystic kidney disease protein, PKD1 809
P. Devarajan and
P. R. Stabach and
A. S. Mann and
T. Ardito and
M. Kashgarian and
J. S. Morrow Identification of a small cytoplasmic
ankyrin (AnkG119) in the kidney and
muscle that binds beta I sigma spectrin
and associates with the Golgi apparatus 819
E. A. Vaisberg and
P. M. Grissom and
J. R. McIntosh Mammalian cells express three distinct
dynein heavy chains that are localized
to different cytoplasmic organelles . . 831
B. M. McCartney and
R. G. Fehon Distinct cellular and subcellular
patterns of expression imply distinct
functions for the \bionameDrosophila
homologues of moesin and the
neurofibromatosis 2 tumor suppressor,
merlin . . . . . . . . . . . . . . . . . 843
M. Galou and
E. Colucci-Guyon and
D. Ensergueix and
J. L. Ridet and
M. Gimenez y Ribotta and
A. Privat and
C. Babinet and
P. Dupouey Disrupted glial fibrillary acidic
protein network in astrocytes from
vimentin knockout mice . . . . . . . . . 853
Y. Matsui and
R. Matsui and
R. Akada and
A. Toh-e Yeast src homology region 3
domain-binding proteins involved in bud
formation . . . . . . . . . . . . . . . 865
L. Bender and
H. S. Lo and
H. Lee and
V. Kokojan and
V. Peterson and
A. Bender Associations among PH and SH3
domain-containing proteins and Rho-type
GTPases in Yeast . . . . . . . . . . . . 879
C. A. Lowell and
L. Fumagalli and
G. Berton Deficiency of Src family kinases
p59/61hck and p58c-fgr results in
defective adhesion-dependent neutrophil
functions . . . . . . . . . . . . . . . 895
R. N. Knibbs and
R. A. Craig and
S. Natsuka and
A. Chang and
M. Cameron and
J. B. Lowe and
L. M. Stoolman The fucosyltransferase FucT--VII
regulates E-selectin ligand synthesis in
human T cells . . . . . . . . . . . . . 911
X. Z. Huang and
J. F. Wu and
D. Cass and
D. J. Erle and
D. Corry and
S. G. Young and
R. V. Farese and
D. Sheppard Inactivation of the integrin beta 6
subunit gene reveals a role of
epithelial integrins in regulating
inflammation in the lung and skin . . . 921
G. Baurén and
W. Q. Jiang and
K. Bernholm and
F. Gu and
L. Wieslander Demonstration of a dynamic,
transcription-dependent organization of
pre-mRNA splicing factors in polytene
nuclei . . . . . . . . . . . . . . . . . 929
Y. N. Osheim and
E. B. Mougey and
J. Windle and
M. Anderson and
M. O'Reilly and
O. L. Miller and
A. Beyer and
B. Sollner-Webb Metazoan rDNA enhancer acts by making
more genes transcriptionally active . . 943
J. Fang and
R. M. Benbow Nuclear proteins of quiescent
\bionameXenopus laevis cells inhibit DNA
replication in intact and permeabilized
nuclei . . . . . . . . . . . . . . . . . 955
D. J. Sweet and
L. Gerace A GTPase distinct from Ran is involved
in nuclear protein import . . . . . . . 971
K. L. Carey and
S. A. Richards and
K. M. Lounsbury and
I. G. Macara Evidence using a green fluorescent
protein-glucocorticoid receptor chimera
that the Ran/TC4 GTPase mediates an
essential function independent of
nuclear protein import . . . . . . . . . 985
M. H. Cardone and
B. L. Smith and
P. A. Mennitt and
D. Mochly-Rosen and
R. B. Silver and
K. E. Mostov Signal transduction by the polymeric
immunoglobulin receptor suggests a role
in regulation of receptor transcytosis 997
L. K. Timson Gauen and
M. E. Linder and
A. S. Shaw Multiple features of the p59fyn src
homology 4 domain define a motif for
immune-receptor tyrosine-based
activation motif (ITAM) binding and for
plasma membrane localization . . . . . . 1007
A. E. Cleves and
D. N. Cooper and
S. H. Barondes and
R. B. Kelly A new pathway for protein export in
\bionameSaccharomyces cerevisiae . . . . 1017
S. P. Denker and
J. M. McCaffery and
G. E. Palade and
P. A. Insel and
M. G. Farquhar Differential distribution of alpha
subunits and beta gamma subunits of
heterotrimeric G proteins on Golgi
membranes of the exocrine pancreas . . . 1027
M. D. Jacobsen and
M. Weil and
M. C. Raff Role of Ced-3/ICE-family proteases in
staurosporine-induced programmed cell
death . . . . . . . . . . . . . . . . . 1041
M. Weil and
M. D. Jacobson and
H. S. Coles and
T. J. Davies and
R. L. Gardner and
K. D. Raff and
M. C. Raff Constitutive expression of the machinery
for programmed cell death . . . . . . . 1053
Z. Xu and
J. R. Marszalek and
M. K. Lee and
P. C. Wong and
J. Folmer and
T. O. Crawford and
S. T. Hsieh and
J. W. Griffin and
D. W. Cleveland Subunit composition of neurofilaments
specifies axonal diameter . . . . . . . 1061
C. C. Lai and
K. Hong and
M. Kinnell and
M. Chalfie and
M. Driscoll Sequence and transmembrane topology of
MEC-4, an ion channel subunit required
for mechanotransduction in
\bionameCaenorhabditis elegans . . . . . 1071
C. Kretz-Remy and
P. Mehlen and
M. E. Mirault and
A. P. Arrigo Inhibition of I kappa B-alpha
phosphorylation and degradation and
subsequent NF-kappa B activation by
glutathione peroxidase overexpression 1083
M. Sachs and
K. M. Weidner and
V. Brinkmann and
I. Walther and
A. Obermeier and
A. Ullrich and
W. Birchmeier Motogenic and morphogenic activity of
epithelial receptor tyrosine kinases . . 1095
P. Lastres and
A. Letamendía and
H. Zhang and
C. Rius and
N. Almendro and
U. Raab and
L. A. López and
C. Langa and
A. Fabra and
M. Letarte and
C. Bernabéu Endoglin modulates cellular responses to
TGF-beta 1 . . . . . . . . . . . . . . . 1109
M. A. Torres and
J. A. Yang-Snyder and
S. M. Purcell and
A. A. DeMarais and
L. L. McGrew and
R. T. Moon Activities of the Wnt-1 class of
secreted signaling factors are
antagonized by the Wnt-5A class and by a
dominant negative cadherin in early
\bionameXenopus development . . . . . . 1123
U. Zabel and
V. Doye and
H. Tekotte and
R. Wepf and
P. Grandi and
E. C. Hurt Nic96p is required for nuclear pore
formation and functionally interacts
with a novel nucleoporin, Nup188p . . . 1141
U. Nehrbass and
M. P. Rout and
S. Maguire and
G. Blobel and
R. W. Wozniak The yeast nucleoporin Nup188p interacts
genetically and physically with the core
structures of the nuclear pore complex 1153
D. M. Koepp and
D. H. Wong and
A. H. Corbett and
P. A. Silver Dynamic localization of the nuclear
import receptor and its interactions
with transport factors . . . . . . . . . 1163
R. A. Chavez and
S. G. Miller and
H. P. Moore A biosynthetic regulated secretory
pathway in constitutive secretory cells 1177
K. Geering and
A. Beggah and
P. Good and
S. Girardet and
S. Roy and
D. Schaer and
P. Jaunin Oligomerization and maturation of
Na,K--ATPase: functional interaction of
the cytoplasmic NH2 terminus of the beta
subunit with the alpha subunit . . . . . 1193
H. Krämer and
M. Phistry Mutations in the \bionameDrosophila hook
gene inhibit endocytosis of the boss
transmembrane ligand into multivesicular
bodies . . . . . . . . . . . . . . . . . 1205
S. Chasserot-Golaz and
N. Vitale and
I. Sagot and
B. Delouche and
S. Dirrig and
L. A. Pradel and
J. P. Henry and
D. Aunis and
M. F. Bader Annexin II in exocytosis: catecholamine
secretion requires the translocation of
p36 to the subplasmalemmal region in
chromaffin cells . . . . . . . . . . . . 1217
K. Takei and
O. Mundigl and
L. Daniell and
P. De Camilli The synaptic vesicle cycle: a single
vesicle budding step involving clathrin
and dynamin . . . . . . . . . . . . . . 1237
S. Aubert and
E. Gout and
R. Bligny and
D. Marty-Mazars and
F. Barrieu and
J. Alabouvette and
F. Marty and
R. Douce Ultrastructural and biochemical
characterization of autophagy in higher
plant cells subjected to carbon
deprivation: control by the supply of
mitochondria with respiratory substrates 1251
L. A. Hannan and
M. Edidin Traffic, polarity, and detergent
solubility of a
glycosylphosphatidylinositol-anchored
protein after LDL-deprivation of MDCK
cells . . . . . . . . . . . . . . . . . 1265
H. V. Goodson and
B. L. Anderson and
H. M. Warrick and
L. A. Pon and
J. A. Spudich Synthetic lethality screen identifies a
novel yeast myosin I gene (MYO5): myosin
I proteins are required for polarization
of the actin cytoskeleton . . . . . . . 1277
R. Hopmann and
J. A. Cooper and
K. G. Miller Actin organization, bristle morphology,
and viability are affected by actin
capping protein mutations in
\bionameDrosophila . . . . . . . . . . . 1293
K. Song and
K. E. Mach and
C. Y. Chen and
T. Reynolds and
C. F. Albright A novel suppressor of ras1 in fission
yeast, byr4, is a dosage-dependent
inhibitor of cytokinesis . . . . . . . . 1307
D. A. Larochelle and
K. K. Vithalani and
A. De Lozanne A novel member of the rho family of
small GTP-binding proteins is
specifically required for cytokinesis 1321
S. Biggins and
I. Ivanovska and
M. D. Rose Yeast ubiquitin-like genes are involved
in duplication of the microtubule
organizing center . . . . . . . . . . . 1331
T. Funakoshi and
S. Takeda and
N. Hirokawa Active transport of photoactivated
tubulin molecules in growing axons
revealed by a new electron microscopic
analysis . . . . . . . . . . . . . . . . 1347
K. E. Miller and
H. C. Joshi Tubulin transport in neurons . . . . . . 1355
E. Allen and
Q. C. Yu and
E. Fuchs Mice expressing a mutant desmosomal
cadherin exhibit abnormalities in
desmosomes, proliferation, and epidermal
differentiation . . . . . . . . . . . . 1367
G. Di Paolo and
V. Pellier and
M. Catsicas and
B. Antonsson and
S. Catsicas and
G. Grenningloh The phosphoprotein stathmin is essential
for nerve growth factor-stimulated
differentiation . . . . . . . . . . . . 1383
N. Demaurex and
G. P. Downey and
T. K. Waddell and
S. Grinstein Intracellular pH regulation during
spreading of human neutrophils . . . . . 1391
M. Chrzanowska-Wodnicka and
K. Burridge Rho-stimulated contractility drives the
formation of stress fibers and focal
adhesions . . . . . . . . . . . . . . . 1403
S. Henderson and
R. Allsopp and
D. Spector and
S. S. Wang and
C. Harley In situ analysis of changes in telomere
size during replicative aging and cell
transformation . . . . . . . . . . . . . 1
S. Grimm and
M. K. Bauer and
P. A. Baeuerle and
K. Schulze-Osthoff Bcl-2 down-regulates the activity of
transcription factor NF-kappaB induced
upon apoptosis . . . . . . . . . . . . . 13
S. Voigt and
B. Jungnickel and
E. Hartmann and
T. A. Rapoport Signal sequence-dependent function of
the TRAM protein during early phases of
protein transport across the endoplasmic
reticulum membrane . . . . . . . . . . . 25
Y. Sakai and
A. Saiganji and
H. Yurimoto and
K. Takabe and
H. Saiki and
N. Kato The absence of Pmp47, a putative yeast
peroxisomal transporter, causes a defect
in transport and folding of a specific
matrix enzyme . . . . . . . . . . . . . 37
J. Q. Xu and
B. A. Harder and
P. Uman and
R. Craig Myosin filament structure in vertebrate
smooth muscle . . . . . . . . . . . . . 53
L. Rònnov-Jessen and
O. W. Petersen A function for filamentous alpha-smooth
muscle actin: retardation of motility in
fibroblasts . . . . . . . . . . . . . . 67
M. Maroto and
J. Arredondo and
D. Goulding and
R. Marco and
B. Bullard and
M. Cervera Drosophila paramyosin/miniparamyosin
gene products show a large diversity in
quantity, localization, and isoform
pattern: a possible role in muscle
maturation and function . . . . . . . . 81
J. A. Rafael and
G. A. Cox and
K. Corrado and
D. Jung and
K. P. Campbell and
J. S. Chamberlain Forced expression of dystrophin deletion
constructs reveals structure-function
correlations . . . . . . . . . . . . . . 93
A. Debec and
R. F. Kalpin and
D. R. Daily and
P. D. McCallum and
W. F. Rothwell and
W. Sullivan Live analysis of free centrosomes in
normal and aphidicolin-treated
\bionameDrosophila embryos . . . . . . . 103
V. Moreau and
A. Madania and
R. P. Martin and
B. Winson The \bionameSaccharomyces cerevisiae
actin-related protein Arp2 is involved
in the actin cytoskeleton . . . . . . . 117
R. T. Cox and
C. Kirkpatrick and
M. Peifer Armadillo is required for adherens
junction assembly, cell polarity, and
morphogenesis during \bionameDrosophila
embryogenesis . . . . . . . . . . . . . 133
H. A. Müller and
E. Wieschaus armadillo, bazooka, and stardust are
critical for early stages in formation
of the zonula adherens and maintenance
of the polarized blastoderm epithelium
in \bionameDrosophila . . . . . . . . . 149
I. S. Näthke and
C. L. Adams and
P. Polakis and
J. H. Sellin and
W. J. Nelson The adenomatous polyposis coli tumor
suppressor protein localizes to plasma
membrane sites involved in active cell
migration . . . . . . . . . . . . . . . 165
D. B. Constam and
M. Calfon and
E. J. Robertson SPC4, SPC6, and the novel protease SPC7
are coexpressed with bone morphogenetic
proteins at distinct sites during
embryogenesis . . . . . . . . . . . . . 181
S. Soddu and
G. Blandino and
R. Scardigli and
S. Coen and
A. Marchetti and
M. G. Rizzo and
G. Bossi and
L. Cimino and
M. Crescenzi and
A. Sacchi Interference with p53 protein inhibits
hematopoietic and muscle differentiation 193
M. Igarashi and
S. Kozaki and
S. Terakawa and
S. Kawano and
C. Ide and
Y. Komiya Growth cone collapse and inhibition of
neurite growth by Botulinum neurotoxin
C1: a t--SNARE is involved in axonal
growth . . . . . . . . . . . . . . . . . 205
M. D. Martin-Bermudo and
N. H. Brown Intracellular signals direct integrin
localization to sites of function in
embryonic muscles . . . . . . . . . . . 217
J. W. Ramos and
D. W. DeSimone \bionameXenopus embryonic cell adhesion
to fibronectin: position-specific
activation of RGD/synergy site-dependent
migratory behavior at gastrulation . . . 227
F. Mainiero and
A. Pepe and
M. Yeon and
Y. Ren and
F. G. Giancotti The intracellular functions of
alpha6beta4 integrin are regulated by
EGF . . . . . . . . . . . . . . . . . . 241
J. J. Campbell and
S. Qin and
K. B. Bacon and
C. R. Mackay and
E. C. Butcher Biology of chemokine and classical
chemoattractant receptors: differential
requirements for adhesion-triggering
versus chemotactic responses in lymphoid
cells . . . . . . . . . . . . . . . . . 255
D. T. Ng and
J. D. Brown and
P. Walter Signal sequences specify the targeting
route to the endoplasmic reticulum
membrane . . . . . . . . . . . . . . . . 269
M. Sato and
K. Sato and
A. Nakano Endoplasmic reticulum localization of
Sec12p is achieved by two mechanisms:
Rer1p-dependent retrieval that requires
the transmembrane domain and
Rer1p-independent retention that
involves the cytoplasmic domain . . . . 279
N. T. Ktistakis and
H. A. Brown and
M. G. Waters and
P. C. Sternweis and
M. G. Roth Evidence that phospholipase D mediates
ADP ribosylation factor-dependent
formation of Golgi coated vesicles . . . 295
H. M. McBride and
I. S. Goping and
G. C. Shore The human mitochondrial import receptor,
hTom20p, prevents a cryptic matrix
targeting sequence from gaining access
to the protein translocation machinery 307
Y. Ma and
A. Kouranov and
S. E. LaSala and
D. J. Schnell Two components of the chloroplast
protein import apparatus, IAP86 and
IAP75, interact with the transit
sequence during the recognition and
translocation of precursor proteins at
the outer envelope . . . . . . . . . . . 315
S. S. Vogel and
P. S. Blank and
J. Zimmerberg Poisson-distributed active fusion
complexes underlie the control of the
rate and extent of exocytosis by calcium 329
J. Lazarovits and
H. Y. Naim and
A. C. Rodriguez and
R. H. Wang and
E. Fire and
C. Bird and
Y. I. Henis and
M. G. Roth Endocytosis of chimeric influenza virus
hemagglutinin proteins that lack a
cytoplasmic recognition feature for
coated pits . . . . . . . . . . . . . . 339
A. Rodríguez and
E. Samoff and
M. G. Rioult and
A. Chung and
N. W. Andrews Host cell invasion by trypanosomes
requires lysosomes and
microtubule/kinesin-mediated transport 349
M. A. Scidmore and
E. R. Fischer and
T. Hackstadt Sphingolipids and glycoproteins are
differentially trafficked to the
\bionameChlamydia trachomatis inclusion 363
J. A. Powell and
L. Petherbridge and
B. E. Flucher Formation of triads without the
dihydropyridine receptor alpha subunits
in cell lines from dysgenic skeletal
muscle . . . . . . . . . . . . . . . . . 375
K. Barkalow and
W. Witke and
D. J. Kwiatkowski and
J. H. Hartwig Coordinated regulation of platelet actin
filament barbed ends by gelsolin and
capping protein . . . . . . . . . . . . 389
F. T. van der Loop and
G. Schaart and
E. D. Timmer and
F. C. Ramaekers and
G. J. van Eys Smoothelin, a novel cytoskeletal protein
specific for smooth muscle cells . . . . 401
S. L. Sanders and
I. Herskowitz The BUD4 protein of yeast, required for
axial budding, is localized to the
mother/BUD neck in a cell
cycle-dependent manner . . . . . . . . . 413
A. Spang and
S. Geissler and
K. Grein and
E. Schiebel gamma-Tubulin-like Tub4p of
\bionameSaccharomyces cerevisiae is
associated with the spindle pole body
substructures that organize microtubules
and is required for mitotic spindle
formation . . . . . . . . . . . . . . . 429
L. G. Marschall and
R. L. Jeng and
J. Mulholland and
T. Stearns Analysis of Tub4p, a yeast
gamma-tubulin-like protein: implications
for microtubule-organizing center
function . . . . . . . . . . . . . . . . 443
H. J. Matthies and
H. B. McDonald and
L. S. Goldstein and
W. E. Theurkauf Anastral meiotic spindle morphogenesis:
role of the non-claret disjunctional
kinesin-like protein . . . . . . . . . . 455
M. G. Tansey and
G. C. Chu and
J. P. Merlie ARIA/HRG regulates AChR epsilon subunit
gene expression at the neuromuscular
synapse via activation of
phosphatidylinositol $3$-kinase and
Ras/MAPK pathway . . . . . . . . . . . . 465
P. Liesi and
J. M. Wright Weaver granule neurons are rescued by
calcium channel antagonists and
antibodies against a neurite outgrowth
domain of the B2 chain of laminin . . . 477
K. M. Albers and
T. N. Perrone and
T. P. Goodness and
M. E. Jones and
M. A. Green and
B. M. Davis Cutaneous overexpression of NT-3
increases sensory and sympathetic neuron
number and enhances touch dome and hair
follicle innervation . . . . . . . . . . 487
C. Paillart and
J. L. Boudier and
J. A. Boudier and
H. Rochat and
F. Couraud and
B. Dargent Activity-induced internalization and
rapid degradation of sodium channels in
cultured fetal neurons . . . . . . . . . 499
T. Sakurai and
R. E. Westenbroek and
J. Rettig and
J. Hell and
W. A. Catterall Biochemical properties and subcellular
distribution of the BI and rbA isoforms
of alpha 1A subunits of brain calcium
channels . . . . . . . . . . . . . . . . 511
P. A. Maher Nuclear Translocation of fibroblast
growth factor (FGF) receptors in
response to FGF-2 . . . . . . . . . . . 529
T. A. Starich and
R. Y. Lee and
C. Panzarella and
L. Avery and
J. E. Shaw eat-5 and unc-7 represent a multigene
family in \bionameCaenorhabditis elegans
involved in cell--cell coupling . . . . 537
B. Angres and
A. Barth and
W. J. Nelson Mechanism for transition from initial to
stable cell--cell adhesion: kinetic
analysis of E-cadherin-mediated adhesion
using a quantitative adhesion assay . . 549
J. Dowling and
Q. C. Yu and
E. Fuchs Beta4 integrin is required for
hemidesmosome formation, cell adhesion
and cell survival . . . . . . . . . . . 559
J. L. Sechler and
Y. Takada and
J. E. Schwarzbauer Altered rate of fibronectin matrix
assembly by deletion of the first type
III repeats . . . . . . . . . . . . . . 573
T. Hu and
T. Guan and
L. Gerace Molecular and functional
characterization of the p62 complex, an
assembly of nuclear pore complex
glycoproteins . . . . . . . . . . . . . 589
B. Schilke and
J. Forster and
J. Davis and
P. James and
W. Walter and
S. Laloraya and
J. Johnson and
B. Miao and
E. Craig The cold sensitivity of a mutant of
\bionameSaccharomyces cerevisiae lacking
a mitochondrial heat shock protein 70 is
suppressed by loss of mitochondrial DNA 603
D. Kasper and
F. Dittmer and
K. von Figura and
R. Pohlmann Neither type of mannose $6$-phosphate
receptor is sufficient for targeting of
lysosomal enzymes along intracellular
routes . . . . . . . . . . . . . . . . . 615
S. Martin and
J. Tellam and
C. Livingstone and
J. W. Slot and
G. W. Gould and
D. E. James The glucose transporter (GLUT-4) and
vesicle-associated membrane protein-2
(VAMP-2) are segregated from recycling
endosomes in insulin-sensitive cells . . 625
C. Arnoult and
Y. Zeng and
H. M. Florman ZP3-dependent activation of sperm cation
channels regulates acrosomal secretion
during mammalian fertilization . . . . . 637
H. Schroeder and
R. Leventis and
S. Shahinian and
P. A. Walton and
J. R. Silvius Lipid-modified, cysteinyl-containing
peptides of diverse structures are
efficiently S-acylated at the plasma
membrane of mammalian cells . . . . . . 647
A. F. Roth and
N. G. Davis Ubiquitination of the yeast a-factor
receptor . . . . . . . . . . . . . . . . 661
C. A. Kelley and
J. R. Sellers and
D. L. Gard and
D. Bui and
R. S. Adelstein and
I. C. Baines Xenopus nonmuscle myosin heavy chain
isoforms have different subcellular
localizations and enzymatic activities 675
P. Chen and
J. E. Murphy-Ullrich and
A. Wells A role for gelsolin in actuating
epidermal growth factor
receptor-mediated cell motility . . . . 689
K. Iwasaki and
J. McCarter and
R. Francis and
T. Schedl emo-1, a \bionameCaenorhabditis elegans
Sec61p gamma homologue, is required for
oocyte development and ovulation . . . . 699
C. Ruhrberg and
M. A. Hajibagheri and
M. Simon and
T. P. Dooley and
F. M. Watt Envoplakin, a novel precursor of the
cornified envelope that has homology to
desmoplakin . . . . . . . . . . . . . . 715
N. K. Haass and
M. A. Kartenbeck and
R. E. Leube Pantophysin is a ubiquitously expressed
synaptophysin homologue and defines
constitutive transport vesicles . . . . 731
C. Bertolotto and
K. Bille and
J. P. Ortonne and
R. Ballotti Regulation of tyrosinase gene expression
by cAMP in B16 melanoma cells involves
two CATGTG motifs surrounding the TATA
box: implication of the microphthalmia
gene product . . . . . . . . . . . . . . 747
E. J. Morris and
H. M. Geller Induction of neuronal apoptosis by
camptothecin, an inhibitor of DNA
topoisomerase--I: evidence for cell
cycle-independent toxicity . . . . . . . 757
K. Oritani and
P. W. Kincade Identification of stromal cell products
that interact with pre--B cells . . . . 771
S. Garfinkel and
X. Hu and
I. A. Prudovsky and
G. A. McMahon and
E. M. Kapnik and
S. D. McDowell and
T. Maciag FGF-$1$-dependent proliferative and
migratory responses are impaired in
senescent human umbilical vein
endothelial cells and correlate with the
inability to signal tyrosine
phosphorylation of fibroblast growth
factor receptor-1 substrates . . . . . . 783
S. M. Frisch and
K. Vuori and
E. Ruoslahti and
P. Y. Chan-Hui Control of adhesion-dependent cell
survival by focal adhesion kinase . . . 793
J. Balsamo and
T. Leung and
H. Ernst and
M. K. Zanin and
S. Hoffman and
J. Lilien Regulated binding of PTP1B-like
phosphatase to N-cadherin: control of
cadherin-mediated adhesion by
dephosphorylation of beta-catenin . . . 801
A. M. Ishov and
G. G. Maul The periphery of nuclear domain 10
(ND10) as site of DNA virus deposition 815
K. Reynolds and
A. M. Zimmer and
A. Zimmer Regulation of RAR beta 2 mRNA
expression: evidence for an inhibitory
peptide encoded in the 5'-untranslated
region . . . . . . . . . . . . . . . . . 827
J. A. Gogos and
R. Thompson and
W. Lowry and
B. F. Sloane and
H. Weintraub and
M. Horwitz Gene trapping in differentiating cell
lines: regulation of the lysosomal
protease cathepsin B in skeletal
myoblast growth and fusion . . . . . . . 837
P. E. Purdue and
P. B. Lazarow Targeting of human catalase to
peroxisomes is dependent upon a novel
COOH-terminal peroxisomal targeting
sequence . . . . . . . . . . . . . . . . 849
M. Kielian and
M. R. Klimjack and
S. Ghosh and
W. A. Duffus Mechanisms of mutations inhibiting
fusion and infection by Semliki Forest
virus . . . . . . . . . . . . . . . . . 863
K. Corrado and
J. A. Rafael and
P. L. Mills and
N. M. Cole and
J. A. Faulkner and
K. Wang and
J. S. Chamberlain Transgenic mdx mice expressing
dystrophin with a deletion in the
actin-binding domain display a ``mild
Becker'' phenotype . . . . . . . . . . . 873
E. B. Maryon and
R. Coronado and
P. Anderson unc-68 encodes a ryanodine receptor
involved in regulating \bionameC.
elegans body-wall muscle contraction . . 885
F. Kinose and
S. X. Wang and
U. S. Kidambi and
C. L. Moncman and
D. A. Winkelmann Glycine 699 is pivotal for the motor
activity of skeletal muscle myosin . . . 895
A. Dembinsky and
H. Rubin and
S. Ravid Chemoattractant-mediated increases in
cGMP induce changes in
\bionameDictyostelium myosin II heavy
chain-specific protein kinase C
activities . . . . . . . . . . . . . . . 911
C. X. Zhang and
M. P. Lee and
A. D. Chen and
S. D. Brown and
T. Hsieh Isolation and characterization of a
\bionameDrosophila gene essential for
early embryonic development and
formation of cortical cleavage furrows 923
H. Radhakrishna and
R. D. Klausner and
J. G. Donaldson Aluminum fluoride stimulates surface
protrusions in cells overexpressing the
ARF6 GTPase . . . . . . . . . . . . . . 935
S. Saitoh and
K. Takahashi and
K. Nabeshima and
Y. Yamashita and
Y. Nakaseko and
A. Hirata and
M. Yanagida Aberrant mitosis in fission yeast
mutants defective in fatty acid
synthetase and acetyl CoA carboxylase 949
P. Jin and
Y. Gu and
D. O. Morgan Role of inhibitory CDC2 phosphorylation
in radiation-induced G2 arrest in human
cells . . . . . . . . . . . . . . . . . 963
R. D. Goldman and
S. Khuon and
Y. H. Chou and
P. Opal and
P. M. Steinert The function of intermediate filaments
in cell shape and cytoskeletal integrity 971
E. A. Bornslaeger and
C. M. Corcoran and
T. S. Stappenbeck and
K. J. Green Breaking the connection: displacement of
the desmosomal plaque protein
desmoplakin from cell--cell interfaces
disrupts anchorage of intermediate
filament bundles and alters
intercellular junction assembly . . . . 985
B. H. Keon and
S. Schäfer and
C. Kuhn and
C. Grund and
W. W. Franke Symplekin, a novel type of tight
junction plaque protein . . . . . . . . 1003
H. Li and
T. F. Liu and
A. Lazrak and
C. Peracchia and
G. S. Goldberg and
P. D. Lampe and
R. G. Johnson Properties and regulation of gap
junctional hemichannels in the plasma
membranes of cultured cells . . . . . . 1019
M. S. Balda and
J. A. Whitney and
C. Flores and
S. González and
M. Cereijido and
K. Matter Functional dissociation of paracellular
permeability and transepithelial
electrical resistance and disruption of
the apical-basolateral intramembrane
diffusion barrier by expression of a
mutant tight junction membrane protein 1031
F. Castets and
M. Bartoli and
J. V. Barnier and
G. Baillat and
P. Salin and
A. Moqrich and
J. P. Bourgeois and
F. Denizot and
G. Rougon and
G. Calothy and
A. Monneron A novel calmodulin-binding protein,
belonging to the WD-repeat family, is
localized in dendrites of a subset of
CNS neurons . . . . . . . . . . . . . . 1051
C. Weber and
R. Alon and
B. Moser and
T. A. Springer Sequential regulation of alpha 4 beta 1
and alpha 5 beta 1 integrin avidity by
CC chemokines in monocytes: implications
for transendothelial chemotaxis . . . . 1063
R. A. Clark and
R. Alon and
T. A. Springer CD44 and hyaluronan-dependent rolling
interactions of lymphocytes on tonsillar
stroma . . . . . . . . . . . . . . . . . 1075
A. R. Günthert and
J. Sträter and
U. von Reyher and
C. Henne and
S. Joos and
K. Koretz and
G. Moldenhauer and
P. H. Krammer and
P. Möller Early detachment of colon carcinoma
cells during CD95(APO-1/Fas)-mediated
apoptosis. I. De-adhesion from
hyaluronate by shedding of CD44 . . . . 1089
J. B. Rattner and
M. J. Hendzel and
C. S. Furbee and
M. T. Muller and
D. P. Bazett-Jones Topoisomerase II alpha is associated
with the mammalian centromere in a cell
cycle- and species-specific manner and
is required for proper
centromere/kinetochore structure . . . . 1097
H. Scherthan and
S. Weich and
H. Schwegler and
C. Heyting and
M. Härle and
T. Cremer Centromere and telomere movements during
early meiotic prophase of mouse and man
are associated with the onset of
chromosome pairing . . . . . . . . . . . 1109
B. C. Williams and
M. Gatti and
M. L. Goldberg Bipolar spindle attachments affect
redistributions of ZW10, a
\bionameDrosophila
centromere/kinetochore component
required for accurate chromosome
segregation . . . . . . . . . . . . . . 1127
R. Bastos and
A. Lin and
M. Enarson and
B. Burke Targeting and function in mRNA export of
nuclear pore complex protein Nup153 . . 1141
S. A. Richards and
K. M. Lounsbury and
K. L. Carey and
I. G. Macara A nuclear export signal is essential for
the cytosolic localization of the Ran
binding protein, RanBP1 . . . . . . . . 1157
E. J. Smart and
C. Mineo and
R. G. Anderson Clustered folate receptors deliver
$5$-methyltetrahydrofolate to cytoplasm
of MA104 cells . . . . . . . . . . . . . 1169
B. E. Stronach and
S. E. Siegrist and
M. C. Beckerle Two muscle-specific LIM proteins in
\bionameDrosophila . . . . . . . . . . . 1179
A. M. Sydor and
A. L. Su and
F. S. Wang and
A. Xu and
D. G. Jay Talin and vinculin play distinct roles
in filopodial motility in the neuronal
growth cone . . . . . . . . . . . . . . 1197
K. I. Anderson and
Y. L. Wang and
J. V. Small Coordination of protrusion and
translocation of the keratocyte involves
rolling of the cell body . . . . . . . . 1209
T. A. Ryan and
L. Li and
L. S. Chin and
P. Greengard and
S. J. Smith Synaptic vesicle recycling in synapsin I
knock-out mice . . . . . . . . . . . . . 1219
J. P. Norcott and
R. Solari and
D. F. Cutler Targeting of P-selectin to two regulated
secretory organelles in PC12 cells . . . 1229
T. Imaizumi-Scherrer and
D. M. Faust and
J. C. Bénichou and
R. Hellio and
M. C. Weiss Accumulation in fetal muscle and
localization to the neuromuscular
junction of cAMP-dependent protein
kinase A regulatory and catalytic
subunits RI alpha and C alpha . . . . . 1241
D. J. Milner and
G. Weitzer and
D. Tran and
A. Bradley and
Y. Capetanaki Disruption of muscle architecture and
myocardial degeneration in mice lacking
desmin . . . . . . . . . . . . . . . . . 1255
Y. S. Tao and
R. A. Edwards and
B. Tubb and
S. Wang and
J. Bryan and
P. D. McCrea beta-Catenin associates with the
actin-bundling protein fascin in a
noncadherin complex . . . . . . . . . . 1271
S. Orsulic and
M. Peifer An in vivo structure-function study of
armadillo, the beta-catenin homologue,
reveals both separate and overlapping
regions of the protein required for cell
adhesion and for wingless signaling . . 1283
J. Xu and
M. M. Zutter and
S. A. Santoro and
R. A. Clark PDGF induction of alpha 2 integrin gene
expression is mediated by protein kinase
C-zeta . . . . . . . . . . . . . . . . . 1301
F. P. Lindberg and
H. D. Gresham and
M. I. Reinhold and
E. J. Brown Integrin-associated protein
immunoglobulin domain is necessary for
efficient vitronectin bead binding . . . 1313
J. M. Lewis and
D. A. Cheresh and
M. A. Schwartz Protein kinase C regulates alpha v beta
$5$-dependent cytoskeletal associations
and focal adhesion kinase
phosphorylation . . . . . . . . . . . . 1323
G. Bou-Gharios and
L. A. Garrett and
J. Rossert and
K. Niederreither and
H. Eberspaecher and
C. Smith and
C. Black and
B. Crombrugghe A potent far-upstream enhancer in the
mouse pro alpha 2(I) collagen gene
regulates expression of reporter genes
in transgenic mice . . . . . . . . . . . 1333
J. A. Cooper and
D. P. Kiehart Septins may form a ubiquitous family of
cytoskeletal filaments . . . . . . . . . 1345
M. Gotta and
T. Laroche and
A. Formenton and
L. Maillet and
H. Scherthan and
S. M. Gasser The clustering of telomeres and
colocalization with Rap1, Sir3, and Sir4
proteins in wild-type
\bionameSaccharomyces cerevisiae . . . . 1349
S. Nakielny and
G. Dreyfuss The hnRNP C proteins contain a nuclear
retention sequence that can override
nuclear export signals . . . . . . . . . 1365
M. Schmitt and
W. Neupert and
T. Langer The molecular chaperone Hsp78 confers
compartment-specific thermotolerance to
mitochondria . . . . . . . . . . . . . . 1375
J. H. Kim and
C. A. Lingwood and
D. B. Williams and
W. Furuya and
M. F. Manolson and
S. Grinstein Dynamic measurement of the pH of the
Golgi complex in living cells using
retrograde transport of the verotoxin
receptor . . . . . . . . . . . . . . . . 1387
J. Prestle and
K. Pfizenmaier and
J. Brenner and
F. J. Johannes Protein kinase C mu is located at the
Golgi compartment . . . . . . . . . . . 1401
B. Sönnichsen and
R. Watson and
H. Clausen and
T. Misteli and
G. Warren Sorting by COP I-coated vesicles under
interphase and mitotic conditions . . . 1411
L. Pierini and
D. Holowka and
B. Baird Fc epsilon RI-mediated association of
$6$-micron beads with RBL-2H3 mast cells
results in exclusion of signaling
proteins from the forming phagosome and
abrogation of normal downstream
signaling . . . . . . . . . . . . . . . 1427
W. M. Obermann and
M. Gautel and
F. Steiner and
P. F. van der Ven and
K. Weber and
D. O. Fürst The structure of the sarcomeric M band:
localization of defined domains of
myomesin, M-protein, and the 250-kD
carboxy-terminal region of titin by
immunoelectron microscopy . . . . . . . 1441
B. Nikolic and
E. Mac Nulty and
B. Mir and
G. Wiche Basic amino acid residue cluster within
nuclear targeting sequence motif is
essential for cytoplasmic
plectin-vimentin network junctions . . . 1455
D. F. Woods and
C. Hough and
D. Peel and
G. Callaini and
P. J. Bryant Dlg protein is required for junction
structure, cell polarity, and
proliferation control in
\bionameDrosophila epithelia . . . . . . 1469
P. H. Vachon and
F. Loechel and
H. Xu and
U. M. Wewer and
E. Engvall Merosin and laminin in myogenesis;
specific requirement for merosin in
myotube stability and survival . . . . . 1483
C. Hagios and
M. Koch and
J. Spring and
M. Chiquet and
R. Chiquet-Ehrismann Tenascin-Y: a protein of novel domain
structure is secreted by differentiated
fibroblasts of muscle connective tissue 1499
G. C. Zondag and
W. H. Moolenaar and
M. F. Gebbink Lack of association between receptor
protein tyrosine phosphatase RPTP mu and
cadherins . . . . . . . . . . . . . . . 1513
R. M. Kypta and
H. Su and
L. F. Reichardt Association between a transmembrane
protein tyrosine phosphatase and the
cadherin-catenin complex . . . . . . . . 1519
M. H. Wong and
M. T. Filbin Dominant-negative effect on adhesion by
myelin Po protein truncated in its
cytoplasmic domain . . . . . . . . . . . 1531
P. J. Van Haastert and
J. D. Bishop and
R. H. Gomer The cell density factor CMF regulates
the chemoattractant receptor cAR1 in
\bionameDictyostelium . . . . . . . . . 1543
A. Huttenlocher and
M. H. Ginsberg and
A. F. Horwitz Modulation of cell migration by
integrin-mediated cytoskeletal linkages
and ligand-binding affinity . . . . . . 1551
G. Deng and
S. A. Curriden and
S. Wang and
S. Rosenberg and
D. J. Loskutoff Is plasminogen activator inhibitor-1 the
molecular switch that governs urokinase
receptor-mediated cell adhesion and
release? . . . . . . . . . . . . . . . . 1563
N. Tsumaki and
T. Kimura and
Y. Matsui and
K. Nakata and
T. Ochi Separable cis-regulatory elements that
contribute to tissue- and site-specific
alpha 2(XI) collagen gene expression in
the embryonic mouse cartilage . . . . . 1573
B. Distel and
R. Erdmann and
S. J. Gould and
G. Blobel and
D. I. Crane and
J. M. Cregg and
G. Dodt and
Y. Fujiki and
J. M. Goodman and
W. W. Just and
J. A. Kiel and
W. H. Kunau and
P. B. Lazarow and
G. P. Mannaerts and
H. W. Moser and
T. Osumi and
R. A. Rachubinski and
A. Roscher and
S. Subramani and
H. F. Tabak and
T. Tsukamoto and
D. Valle and
I. van der Klei and
P. P. van Veldhoven and
M. Veenhuis A unified nomenclature for peroxisome
biogenesis factors . . . . . . . . . . . 1
H. P. Erickson and
D. Stoffler Protofilaments and rings, two
conformations of the tubulin family
conserved from bacterial FtsZ to
alpha/beta and gamma tubulin . . . . . . 5
G. Zhang and
M. L. Zapp and
G. Yan and
M. R. Green Localization of HIV-1 RNA in mammalian
nuclei . . . . . . . . . . . . . . . . . 9
S. I. Bannykh and
T. Rowe and
W. E. Balch The organization of endoplasmic
reticulum export complexes . . . . . . . 19
M. Hirao and
N. Sato and
T. Kondo and
S. Yonemura and
M. Monden and
T. Sasaki and
Y. Takai and
S. Tsukita and
S. Tsukita Regulation mechanism of ERM
(ezrin/radixin/moesin) protein/plasma
membrane association: possible
involvement of phosphatidylinositol
turnover and Rho-dependent signaling
pathway . . . . . . . . . . . . . . . . 37
D. Faulstich and
S. Auerbach and
L. Orci and
M. Ravazzola and
S. Wegchingel and
F. Lottspeich and
G. Stenbeck and
C. Harter and
F. T. Wieland and
H. Tschochner Architecture of coatomer: molecular
characterization of delta--COP and
protein interactions within the complex 53
R. Blumenthal and
D. P. Sarkar and
S. Durell and
D. E. Howard and
S. J. Morris Dilation of the influenza hemagglutinin
fusion pore revealed by the kinetics of
individual cell--cell fusion events . . 63
S. Bagai and
R. A. Lamb Truncation of the COOH-terminal region
of the paramyxovirus SV5 fusion protein
leads to hemifusion but not complete
fusion . . . . . . . . . . . . . . . . . 73
S. J. Gould and
J. E. Kalish and
J. C. Morrell and
J. Bjorkman and
A. J. Urquhart and
D. I. Crane Pex13p is an SH3 protein of the
peroxisome membrane and a docking factor
for the predominantly cytoplasmic PTs1
receptor . . . . . . . . . . . . . . . . 85
Y. Elgersma and
L. Kwast and
A. Klein and
T. Voorn-Brouwer and
M. van den Berg and
B. Metzig and
T. America and
H. F. Tabak and
B. Distel The SH3 domain of the
\bionameSaccharomyces cerevisiae
peroxisomal membrane protein Pex13p
functions as a docking site for Pex5p, a
mobile receptor for the import
PTS1-containing proteins . . . . . . . . 97
R. Erdmann and
G. Blobel Identification of Pex13p a peroxisomal
membrane receptor for the PTS1
recognition factor . . . . . . . . . . . 111
P. A. Marshall and
J. M. Dyer and
M. E. Quick and
J. M. Goodman Redox-sensitive homodimerization of
Pex11p: a proposed mechanism to regulate
peroxisomal division . . . . . . . . . . 123
G. Odorizzi and
A. Pearse and
D. Domingo and
I. S. Trowbridge and
C. R. Hopkins Apical and basolateral endosomes of MDCK
cells are interconnected and contain a
polarized sorting mechanism . . . . . . 139
J. Peränen and
P. Auvinen and
H. Virta and
R. Wepf and
K. Simons Rab8 promotes polarized membrane
transport through reorganization of
actin and microtubules in fibroblasts 153
D. A. Schafer and
P. B. Jennings and
J. A. Cooper Dynamics of capping protein and actin
assembly in vitro: uncapping barbed ends
by polyphosphoinositides . . . . . . . . 169
A. Muto and
S. Kume and
T. Inoue and
H. Okano and
K. Mikoshiba Calcium waves along the cleavage furrows
in cleavage-stage \bionameXenopus
embryos and its inhibition by heparin 181
M. Wilding and
E. M. Wright and
R. Patel and
G. Ellis-Davies and
M. Whitaker Local perinuclear calcium signals
associated with mitosis-entry in early
sea urchin embryos . . . . . . . . . . . 191
Y. Zhai and
P. J. Kronebusch and
P. M. Simon and
G. G. Borisy Microtubule dynamics at the G2/M
transition: abrupt breakdown of
cytoplasmic microtubules at nuclear
envelope breakdown and implications for
spindle morphogenesis . . . . . . . . . 201
P. Ruiz and
V. Brinkmann and
B. Ledermann and
M. Behrend and
C. Grund and
C. Thalhammer and
F. Vogel and
C. Birchmeier and
U. Günthert and
W. W. Franke and
W. Birchmeier Targeted mutation of plakoglobin in mice
reveals essential functions of
desmosomes in the embryonic heart . . . 215
M. Blessing and
P. Schirmacher and
S. Kaiser Overexpression of bone morphogenetic
protein-6 (BMP-6) in the epidermis of
transgenic mice: inhibition or
stimulation of proliferation depending
on the pattern of transgene expression
and formation of psoriatic lesions . . . 227
S. Fazeli and
D. J. Wells and
C. Hobbs and
F. S. Walsh Altered secondary myogenesis in
transgenic animals expressing the neural
cell adhesion molecule under the control
of a skeletal muscle alpha-actin
promoter . . . . . . . . . . . . . . . . 241
S. Kunz and
U. Ziegler and
B. Kunz and
P. Sonderegger Intracellular signaling is changed after
clustering of the neural cell adhesion
molecules axonin-1 and NgCAM during
neurite fasciculation . . . . . . . . . 253
F. Guinet and
J. A. Dvorak and
H. Fujioka and
D. B. Keister and
O. Muratova and
D. C. Kaslow and
M. Aikawa and
A. B. Vaidya and
T. E. Wellems A developmental defect in Plasmodium
falciparum male gametogenesis . . . . . 269
D. S. Friend and
N. Ghildyal and
K. F. Austen and
M. F. Gurish and
R. Matsumoto and
R. L. Stevens Mast cells that reside at different
locations in the jejunum of mice
infected with Trichinella spiralis
exhibit sequential changes in their
granule ultrastructure and chymase
phenotype . . . . . . . . . . . . . . . 279
R. D. Vale Switches, latches, and amplifiers:
common themes of G proteins and
molecular motors . . . . . . . . . . . . 291
E. Bridge and
K. U. Riedel and
B. M. Johansson and
U. Pettersson Spliced exons of adenovirus late RNAs
colocalize with snRNP in a specific
nuclear domain . . . . . . . . . . . . . 303
A. Khodjakov and
C. L. Rieder Kinetochores moving away from their
associated pole do not exert a
significant pushing force on the
chromosome . . . . . . . . . . . . . . . 315
N. Shulga and
P. Roberts and
Z. Gu and
L. Spitz and
M. M. Tabb and
M. Nomura and
D. S. Goldfarb In vivo nuclear transport kinetics in
\bionameSaccharomyces cerevisiae: a role
for heat shock protein 70 during
targeting and translocation . . . . . . 329
M. S. Marks and
L. Woodruff and
H. Ohno and
J. S. Bonifacino Protein targeting by tyrosine- and
di-leucine-based signals: evidence for
distinct saturable components . . . . . 341
J. P. Simon and
I. E. Ivanov and
M. Adesnik and
D. D. Sabatini The production of post-Golgi vesicles
requires a protein kinase C-like
molecule, but not its phosphorylating
activity . . . . . . . . . . . . . . . . 355
P. E. Hoppe and
R. H. Waterston Hydrophobicity variations along the
surface of the coiled-coil rod may
mediate striated muscle myosin assembly
in \bionameCaenorhabditis elegans . . . 371
V. Muresan and
C. P. Godek and
T. S. Reese and
B. J. Schnapp Plus-end motors override minus-end
motors during transport of squid axon
vesicles on microtubules . . . . . . . . 383
T. Gaglio and
A. Saredi and
J. B. Bingham and
M. J. Hasbani and
S. R. Gill and
T. A. Schroer and
D. A. Compton Opposing motor activities are required
for the organization of the mammalian
mitotic spindle pole . . . . . . . . . . 399
W. Wang and
P. A. Hansen and
B. A. Marshall and
J. O. Holloszy and
M. Mueckler Insulin unmasks a COOH-terminal Glut4
epitope and increases glucose transport
across T-tubules in skeletal muscle . . 415
J. C. Engert and
E. B. Berglund and
N. Rosenthal Proliferation precedes differentiation
in IGF--I--stimulated myogenesis . . . . 431
B. G. Novitch and
G. J. Mulligan and
T. Jacks and
A. B. Lassar Skeletal muscle cells lacking the
retinoblastoma protein display defects
in muscle gene expression and accumulate
in S and G2 phases of the cell cycle . . 441
R. M. Jotte and
J. T. Holt Myristylation of FBR v-fos dictates the
differentiation pathways in malignant
osteosarcoma . . . . . . . . . . . . . . 457
M. Oulad-Abdelghani and
P. Bouillet and
D. Décimo and
A. Gansmuller and
S. Heyberger and
P. Dollé and
S. Bronner and
Y. Lutz and
P. Chambon Characterization of a premeiotic germ
cell-specific cytoplasmic protein
encoded by Stra8, a novel retinoic
acid-responsive gene . . . . . . . . . . 469
B. Allet and
A. Hochmann and
I. Martinou and
A. Berger and
M. Missotten and
B. Antonsson and
R. Sadoul and
J. C. Martinou and
L. Bernasconi Dissecting processing and apoptotic
activity of a cysteine protease by
mutant analysis . . . . . . . . . . . . 479
W. M. Brieher and
A. S. Yap and
B. M. Gumbiner Lateral dimerization is required for the
homophilic binding activity of
C-cadherin . . . . . . . . . . . . . . . 487
A. Del Maschio and
A. Zanetti and
M. Corada and
Y. Rival and
L. Ruco and
M. G. Lampugnani and
E. Dejana Polymorphonuclear leukocyte adhesion
triggers the disorganization of
endothelial cell-to-cell adherens
junctions . . . . . . . . . . . . . . . 497
R. Menegazzi and
S. Busetto and
P. Dri and
R. Cramer and
P. Patriarca Chloride ion efflux regulates adherence,
spreading, and respiratory burst of
neutrophils stimulated by tumor necrosis
factor-alpha (TNF) on biologic surfaces 511
O. Spertini and
A. S. Cordey and
N. Monai and
L. Giuffr\`e and
M. Schapira P-selectin glycoprotein ligand 1 is a
ligand for L-selectin on neutrophils,
monocytes, and CD34+ hematopoietic
progenitor cells . . . . . . . . . . . . 523
A. G. Gao and
F. P. Lindberg and
J. M. Dimitry and
E. J. Brown and
W. A. Frazier Thrombospondin modulates alpha v beta 3
function through integrin-associated
protein . . . . . . . . . . . . . . . . 533
R. D. Shelby and
K. M. Hahn and
K. F. Sullivan Dynamic elastic behavior of
alpha-satellite DNA domains visualized
in situ in living human cells . . . . . 545
N. C. Chi and
E. J. Adam and
G. D. Visser and
S. A. Adam RanBP1 stabilizes the interaction of Ran
with p97 nuclear protein import . . . . 559
E. M. Stone and
L. Pillus Activation of an MAP kinase cascade
leads to Sir3p hyperphosphorylation and
strengthens transcriptional silencing 571
M. J. Kuehn and
R. Schekman and
P. O. Ljungdahl Amino acid permeases require COPII
components and the ER resident membrane
protein Shr3p for packaging into
transport vesicles in vitro . . . . . . 585
J. S. Chuang and
R. W. Schekman Differential trafficking and timed
localization of two chitin synthase
proteins, Chs2p and Chs3p . . . . . . . 597
R. Wubbolts and
M. Fernandez-Borja and
L. Oomen and
D. Verwoerd and
H. Janssen and
J. Calafat and
A. Tulp and
S. Dusseljee and
J. Neefjes Direct vesicular transport of MHC class
II molecules from lysosomal structures
to the cell surface . . . . . . . . . . 611
E. Hong and
A. R. Davidson and
C. A. Kaiser A pathway for targeting soluble
misfolded proteins to the yeast vacuole 623
A. Wilde and
F. M. Brodsky In vivo phosphorylation of adaptors
regulates their interaction with
clathrin . . . . . . . . . . . . . . . . 635
G. A. Smith and
J. A. Theriot and
D. A. Portnoy The tandem repeat domain in the
\bionameListeria monocytogenes ActA
protein controls the rate of actin-based
motility, the percentage of moving
bacteria, and the localization of
vasodilator-stimulated phosphoprotein
and profilin . . . . . . . . . . . . . . 647
I. N. Rybakova and
K. J. Amann and
J. M. Ervasti A new model for the interaction of
dystrophin with F-actin . . . . . . . . 661
A. J. Kreuz and
A. Simcox and
D. Maughan Alterations in flight muscle
ultrastructure and function in
\bionameDrosophila tropomyosin mutants 673
M. O. Trielli and
P. R. Andreassen and
F. B. Lacroix and
R. L. Margolis Differential Taxol-dependent arrest of
transformed and nontransformed cells in
the G1 phase of the cell cycle, and
specific-related mortality of
transformed cells . . . . . . . . . . . 689
B. Campenot and
K. Lund and
D. L. Senger Delivery of newly synthesized tubulin to
rapidly growing distal axons of
sympathetic neurons in compartmented
cultures . . . . . . . . . . . . . . . . 701
J. R. Marszalek and
T. L. Williamson and
M. K. Lee and
Z. Xu and
P. N. Hoffman and
M. W. Becher and
T. O. Crawford and
D. W. Cleveland Neurofilament subunit NF--H modulates
axonal diameter by selectively slowing
neurofilament transport . . . . . . . . 711
N. Valtz and
I. Herskowitz Pea2 protein of yeast is localized to
sites of polarized growth and is
required for efficient mating and
bipolar budding . . . . . . . . . . . . 725
L. Elia and
L. Marsh Role of the ABC transporter Ste6 in cell
fusion during yeast conjugation . . . . 741
S. M. Marfatia and
J. H. Morais Cabral and
L. Lin and
C. Hough and
P. J. Bryant and
L. Stolz and
A. H. Chishti Modular organization of the PDZ domains
in the human discs-large protein
suggests a mechanism for coupling PDZ
domain-binding proteins to ATP and the
membrane cytoskeleton . . . . . . . . . 753
N. Uchida and
Y. Honjo and
K. R. Johnson and
M. J. Wheelock and
M. Takeichi The catenin/cadherin adhesion system is
localized in synaptic junctions
bordering transmitter release zones . . 767
C. Soans and
J. A. Holash and
Y. Pavlova and
E. B. Pasquale Developmental expression and distinctive
tyrosine phosphorylation of the
Eph-related receptor tyrosine kinase
Cek9 . . . . . . . . . . . . . . . . . . 781
J. H. Koenig and
K. Ikeda Synaptic vesicles have two distinct
recycling pathways . . . . . . . . . . . 797
Z. Z. Wang and
S. F. Hardy and
Z. W. Hall Membrane tethering enables an
extracellular domain of the
acetylcholine receptor alpha subunit to
form a heterodimeric ligand-binding site 809
F. Reichsman and
L. Smith and
S. Cumberledge Glycosaminoglycans can modulate
extracellular localization of the
wingless protein and promote signal
transduction . . . . . . . . . . . . . . 819
J. T. Yang and
T. A. Rando and
W. A. Mohler and
H. Rayburn and
H. M. Blau and
R. O. Hynes Genetic analysis of alpha 4 integrin
functions in the development of mouse
skeletal muscle . . . . . . . . . . . . 829
R. C. Fuhlbrigge and
R. Alon and
K. D. Puri and
J. B. Lowe and
T. A. Springer Sialylated, fucosylated ligands for
L-selectin expressed on leukocytes
mediate tethering and rolling adhesions
in physiologic flow conditions . . . . . 837
R. Alon and
R. C. Fuhlbrigge and
E. B. Finger and
T. A. Springer Interactions through L-selectin between
leukocytes and adherent leukocytes
nucleate rolling adhesions on selectins
and VCAM-1 in shear flow . . . . . . . . 849
M. E. Ludérus and
B. van Steensel and
L. Chong and
O. C. Sibon and
F. F. Cremers and
T. de Lange Structure, subnuclear distribution, and
nuclear matrix association of the
mammalian telomeric complex . . . . . . 867
A. F. Davis and
D. A. Clayton In situ localization of mitochondrial
DNA replication in intact mammalian
cells . . . . . . . . . . . . . . . . . 883
T. Rowe and
M. Aridor and
J. M. McCaffery and
H. Plutner and
C. Nuoffer and
W. E. Balch COPII vesicles derived from mammalian
endoplasmic reticulum microsomes recruit
COPI . . . . . . . . . . . . . . . . . . 895
O. Ullrich and
S. Reinsch and
S. Urbé and
M. Zerial and
R. G. Parton Rab11 regulates recycling through the
pericentriolar recycling endosome . . . 913
S. E. Holstein and
H. Ungewickell and
E. Ungewickell Mechanism of clathrin basket
dissociation: separate functions of
protein domains of the DnaJ homologue
auxilin . . . . . . . . . . . . . . . . 925
J. M. Leiper and
P. B. Oatey and
C. J. Danpure Inhibition of alanine: glyoxylate
aminotransferase 1 dimerization is a
prerequisite for its
peroxisome-to-mitochondrion mistargeting
in primary hyperoxaluria type 1 . . . . 939
G. Liu and
J. Tang and
B. T. Edmonds and
J. Murray and
S. Levin and
J. Condeelis F-actin sequesters elongation factor
1alpha from interaction with
aminoacyl-tRNA in a pH-dependent
reaction . . . . . . . . . . . . . . . . 953
F. Rivero and
R. Furukawa and
A. A. Noegel and
M. Fechheimer \bionameDictyostelium discoideum cells
lacking the 34,000-dalton actin-binding
protein can grow, locomote, and develop,
but exhibit defects in regulation of
cell structure and movement: a case of
partial redundancy . . . . . . . . . . . 965
S. P. Wheatley and
Y. Wang Midzone microtubule bundles are
continuously required for cytokinesis in
cultured epithelial cells . . . . . . . 981
T. M. Svitkina and
A. B. Verkhovsky and
G. G. Borisy Plectin sidearms mediate interaction of
intermediate filaments with microtubules
and other components of the cytoskeleton 991
C. Mertens and
C. Kuhn and
W. W. Franke Plakophilins 2a and 2b: constitutive
proteins of dual location in the
karyoplasm and the desmosomal plaque . . 1009
P. Ouyang and
S. P. Sugrue Characterization of pinin, a novel
protein associated with the
desmosome-intermediate filament complex 1027
F. Q. Li and
A. Coonrod and
M. Horwitz Preferential MyoD homodimer formation
demonstrated by a general method of
dominant negative mutation employing
fusion with a lysosomal protease . . . . 1043
H. Volkmer and
R. Leuschner and
U. Zacharias and
F. G. Rathjen Neurofascin induces neurites by
heterophilic interactions with axonal
NrCAM while NrCAM requires F11 on the
axonal surface to extend neurites . . . 1059
J. H. Hecht and
J. A. Weiner and
S. R. Post and
J. Chun Ventricular zone gene-1 (vzg-1) encodes
a lysophosphatidic acid receptor
expressed in neurogenic regions of the
developing cerebral cortex . . . . . . . 1071
R. S. Slack and
D. J. Belliveau and
M. Rosenberg and
J. Atwal and
H. Lochmüller and
R. Aloyz and
A. Haghighi and
B. Lach and
P. Seth and
E. Cooper and
F. D. Miller Adenovirus-mediated gene transfer of the
tumor suppressor, p53, induces apoptosis
in postmitotic neurons . . . . . . . . . 1085
J. Brock and
K. Midwinter and
J. Lewis and
P. Martin Healing of incisional wounds in the
embryonic chick wing bud:
characterization of the actin
purse-string and demonstration of a
requirement for Rho activation . . . . . 1097
M. C. Brown and
J. A. Perrotta and
C. E. Turner Identification of LIM3 as the principal
determinant of paxillin focal adhesion
localization and characterization of a
novel motif on paxillin directing
vinculin and focal adhesion kinase
binding . . . . . . . . . . . . . . . . 1109
R. A. Lue and
E. Brandin and
E. P. Chan and
D. Branton Two independent domains of hDlg are
sufficient for subcellular targeting:
the PDZ1-2 conformational unit and an
alternatively spliced domain . . . . . . 1125
J. Sleeman and
W. Rudy and
M. Hofmann and
J. Moll and
P. Herrlich and
H. Ponta Regulated clustering of variant CD44
proteins increases their hyaluronate
binding capacity . . . . . . . . . . . . 1139
H. Wang and
Z. Xie and
R. E. Scott Differentiation modulates the balance of
positive and negative Jun/AP-1 DNA
binding activities to regulate cellular
proliferative potential: different
effects in nontransformed and
transformed cells . . . . . . . . . . . 1151
P. Braghetta and
C. Fabbro and
S. Piccolo and
D. Marvulli and
P. Bonaldo and
D. Volpin and
G. M. Bressan Distinct regions control transcriptional
activation of the alpha1(VI) collagen
promoter in different tissues of
transgenic mice . . . . . . . . . . . . 1163
S. Erdmann and
W. Müller and
S. Bahrami and
S. I. Vornehm and
H. Mayer and
P. Bruckner and
K. von der Mark and
H. Burkhardt Differential effects of parathyroid
hormone fragments on collagen gene
expression in chondrocytes . . . . . . . 1179
A. Kurz and
S. Lampel and
J. E. Nickolenko and
J. Bradl and
A. Benner and
R. M. Zirbel and
T. Cremer and
P. Lichter Active and inactive genes localize
preferentially in the periphery of
chromosome territories . . . . . . . . . 1195
S. J. Lawlis and
S. M. Keezer and
J. R. Wu and
D. M. Gilbert Chromosome architecture can dictate
site-specific initiation of DNA
replication in \bionameXenopus egg
extracts . . . . . . . . . . . . . . . . 1207
M. T. Sweet and
K. Jones and
C. D. Allis Phosphorylation of linker histone is
associated with transcriptional
activation in a normally silent nucleus 1219
G. L. Bush and
D. I. Meyer The refolding activity of the yeast heat
shock proteins Ssa1 and Ssa2 defines
their role in protein translocation . . 1229
K. Sohn and
L. Orci and
M. Ravazzola and
M. Amherdt and
M. Bremser and
F. Lottspeich and
K. Fiedler and
J. B. Helms and
F. T. Wieland A major transmembrane protein of
Golgi-derived COPI-coated vesicles
involved in coatomer binding . . . . . . 1239
N. Araki and
M. T. Johnson and
J. A. Swanson A role for phosphoinositide $3$-kinase
in the completion of macropinocytosis
and phagocytosis by macrophages . . . . 1249
I. De Bie and
M. Marcinkiewicz and
D. Malide and
C. Lazure and
K. Nakayama and
M. Bendayan and
N. G. Seidah The isoforms of proprotein convertase
PC5 are sorted to different subcellular
compartments . . . . . . . . . . . . . . 1261
S. Eaton and
R. Wepf and
K. Simons Roles for Rac1 and Cdc42 in planar
polarization and hair outgrowth in the
wing of \bionameDrosophila . . . . . . . 1277
L. G. Tilney and
P. Connelly and
S. Smith and
G. M. Guild F-actin bundles in \bionameDrosophila
bristles are assembled from modules
composed of short filaments . . . . . . 1291
J. W. Murray and
B. T. Edmonds and
G. Liu and
J. Condeelis Bundling of actin filaments by
elongation factor 1 alpha inhibits
polymerization at filament ends . . . . 1309
I. Irminger-Finger and
E. Hurt and
A. Roebuck and
M. A. Collart and
S. J. Edelstein MHP1, an essential gene in
\bionameSaccharomyces cerevisiae
required for microtubule function . . . 1323
M. Deshmukh and
J. Vasilakos and
T. L. Deckwerth and
P. A. Lampe and
B. D. Shivers and
E. M. Johnson Genetic and metabolic status of
NGF-deprived sympathetic neurons saved
by an inhibitor of ICE family proteases 1341
J. Q. Davis and
S. Lambert and
V. Bennett Molecular composition of the node of
Ranvier: identification of
ankyrin-binding cell adhesion molecules
neurofascin (mucin+/third FNIII domain-)
and NrCAM at nodal axon segments . . . . 1355
V. V. Didenko and
P. J. Hornsby Presence of double-strand breaks with
single-base 3' overhangs in cells
undergoing apoptosis but not necrosis 1369
S. M. Frisch and
K. Vuori and
D. Kelaita and
S. Sicks A role for Jun--N--terminal kinase in
anoikis; suppression by bcl-2 and crmA 1377
J. E. Hungerford and
M. T. Compton and
M. L. Matter and
B. G. Hoffstrom and
C. A. Otey Inhibition of pp125FAK in cultured
fibroblasts results in apoptosis . . . . 1383
S. Vagner and
C. Touriol and
B. Galy and
S. Audigier and
M. C. Gensac and
F. Amalric and
F. Bayard and
H. Prats and
A. C. Prats Translation of CUG- but not
AUG-initiated forms of human fibroblast
growth factor 2 is activated in
transformed and stressed cells . . . . . 1391
J. H. Miner and
J. R. Sanes Molecular and functional defects in
kidneys of mice lacking collagen alpha
3(IV): implications for Alport syndrome 1403
J. K. Marchant and
R. A. Hahn and
T. F. Linsenmayer and
D. E. Birk Reduction of type V collagen using a
dominant-negative strategy alters the
regulation of fibrillogenesis and
results in the loss of corneal-specific
fibril morphology . . . . . . . . . . . 1415
R. Eils and
S. Dietzel and
E. Bertin and
E. Schröck and
M. R. Speicher and
T. Ried and
M. Robert-Nicoud and
C. Cremer and
T. Cremer Three-dimensional reconstruction of
painted human interphase chromosomes:
active and inactive X chromosome
territories have similar volumes but
differ in shape and surface structure 1427
L. Rao and
D. Perez and
E. White Lamin proteolysis facilitates nuclear
events during apoptosis . . . . . . . . 1441
M. J. Matunis and
E. Coutavas and
G. Blobel A novel ubiquitin-like modification
modulates the partitioning of the
Ran--GTPase--activating protein RanGAP1
between the cytosol and the nuclear pore
complex . . . . . . . . . . . . . . . . 1457
C. D. Austin and
D. Shields Formation of nascent secretory vesicles
from the trans-Golgi network of
endocrine cells is inhibited by tyrosine
kinase and phosphatase inhibitors . . . 1471
B. Wendland and
J. M. McCaffery and
Q. Xiao and
S. D. Emr A novel fluorescence-activated cell
sorter-based screen for yeast
endocytosis mutants identifies a yeast
homologue of mammalian eps15 . . . . . . 1485
N. Borgese and
D. Aggujaro and
P. Carrera and
G. Pietrini and
M. Bassetti A role for N-myristoylation in protein
targeting: NADH-cytochrome b5 reductase
requires myristic acid for association
with outer mitochondrial but not ER
membranes . . . . . . . . . . . . . . . 1501
W. Rodgers and
J. K. Rose Exclusion of CD45 inhibits activity of
p56lck associated with
glycolipid-enriched membrane domains . . 1515
M. L. Gonzalez-Garay and
F. Cabral alpha-Tubulin limits its own synthesis:
evidence for a mechanism involving
translational repression . . . . . . . . 1525
K. L. Hill and
N. L. Catlett and
L. S. Weisman Actin and myosin function in directed
vacuole movement during cell division in
\bionameSaccharomyces cerevisiae . . . . 1535
V. J. Fincham and
M. Unlu and
V. G. Brunton and
J. D. Pitts and
J. A. Wyke and
M. C. Frame Translocation of Src kinase to the cell
periphery is mediated by the actin
cytoskeleton under the control of the
Rho family of small G proteins . . . . . 1551
C. Wang and
W. F. Pralong and
M. F. Schulz and
G. Rougon and
J. M. Aubry and
S. Pagliusi and
A. Robert and
J. Z. Kiss Functional N--methyl--D--aspartate
receptors in O-2A glial precursor cells:
a critical role in regulating polysialic
acid-neural cell adhesion molecule
expression and cell migration . . . . . 1565
R. Brandenberger and
R. A. Kammerer and
J. Engel and
M. Chiquet Native chick laminin-4 containing the
beta 2 chain (s-laminin) promotes motor
axon growth . . . . . . . . . . . . . . 1583
A. Buchstaller and
S. Kunz and
P. Berger and
B. Kunz and
U. Ziegler and
C. Rader and
P. Sonderegger Cell adhesion molecules NgCAM and
axonin-1 form heterodimers in the
neuronal membrane and cooperate in
neurite outgrowth promotion . . . . . . 1593
D. Lu and
H. Yang and
M. K. Raizada Angiotensin II regulation of
neuromodulation: downstream signaling
mechanism from activation of
mitogen-activated protein kinase . . . . 1609
R. H. Scannevin and
H. Murakoshi and
K. J. Rhodes and
J. S. Trimmer Identification of a cytoplasmic domain
important in the polarized expression
and clustering of the Kv2.1 K+ channel 1619
S. Miyamoto and
H. Teramoto and
J. S. Gutkind and
K. M. Yamada Integrins can collaborate with growth
factors for phosphorylation of receptor
tyrosine kinases and MAP kinase
activation: roles of integrin
aggregation and occupancy of receptors 1633
S. Islam and
T. E. Carey and
G. T. Wolf and
M. J. Wheelock and
K. R. Johnson Expression of N-cadherin by human
squamous carcinoma cells induces a
scattered fibroblastic phenotype with
disrupted cell--cell adhesion . . . . . 1643
O. Vainio and
D. Dunon and
F. A\"\issi and
J. P. Dangy and
K. M. McNagny and
B. A. Imhof HEMCAM, an adhesion molecule expressed
by c-kit+ hemopoietic progenitors . . . 1655
C. M. Alexander and
E. W. Howard and
M. J. Bissell and
Z. Werb Rescue of mammary epithelial cell
apoptosis and entactin degradation by a
tissue inhibitor of metalloproteinases-1
transgene . . . . . . . . . . . . . . . 1669
C. C. Robinett and
A. Straight and
G. Li and
C. Willhelm and
G. Sudlow and
A. Murray and
A. S. Belmont In vivo localization of DNA sequences
and visualization of large-scale
chromatin organization using lac
operator/repressor recognition . . . . . 1685
H. A. Lane and
E. A. Nigg Antibody microinjection reveals an
essential role for human polo-like
kinase 1 (Plk1) in the functional
maturation of mitotic centrosomes . . . 1701
P. Collas and
J. C. Courvalin and
D. Poccia Targeting of membranes to sea urchin
sperm chromatin is mediated by a lamin B
receptor-like integral membrane protein 1715
V. Brizzio and
A. E. Gammie and
G. Nijbroek and
S. Michaelis and
M. D. Rose Cell fusion during yeast mating requires
high levels of a-factor mating pheromone 1727
N. Masumoto and
T. Sasaki and
M. Tahara and
A. Mammoto and
Y. Ikebuchi and
K. Tasaka and
M. Tokunaga and
Y. Takai and
A. Miyake Involvement of Rabphilin-3A in cortical
granule exocytosis in mouse eggs . . . . 1741
A. O. Johnson and
R. N. Ghosh and
K. W. Dunn and
R. Garippa and
J. Park and
S. Mayor and
F. R. Maxfield and
T. E. McGraw Transferrin receptor containing the
SDYQRL motif of TGN38 causes a
reorganization of the recycling
compartment but is not targeted to the
TGN . . . . . . . . . . . . . . . . . . 1749
G. Dodt and
S. J. Gould Multiple PEX genes are required for
proper subcellular distribution and
stability of Pex5p, the PTS1 receptor:
evidence that PTS1 protein import is
mediated by a cycling receptor . . . . . 1763
N. D. Chilcoat and
S. M. Melia and
A. Haddad and
A. P. Turkewitz Granule lattice protein 1 (Grl1p), an
acidic, calcium-binding protein in
\bionameTetrahymena thermophila
dense-core secretory granules,
influences granule size, shape, content
organization, and release but not
protein sorting or condensation . . . . 1775
P. K. Tan and
J. P. Howard and
G. S. Payne The sequence NPFXD defines a new class
of endocytosis signal in
\bionameSaccharomyces cerevisiae . . . . 1789
L. M. Traub and
S. I. Bannykh and
J. E. Rodel and
M. Aridor and
W. E. Balch and
S. Kornfeld AP-$2$-containing clathrin coats
assemble on mature lysosomes . . . . . . 1801
E. A. Holleran and
M. K. Tokito and
S. Karki and
E. L. Holzbaur Centractin (ARP1) associates with
spectrin revealing a potential mechanism
to link dynactin to intracellular
organelles . . . . . . . . . . . . . . . 1815
I. Plonsky and
J. Zimmerberg The initial fusion pore induced by
baculovirus GP64 is large and forms
quickly . . . . . . . . . . . . . . . . 1831
M. Suomalainen and
K. Hultenby and
H. Garoff Targeting of Moloney murine leukemia
virus gag precursor to the site of virus
budding . . . . . . . . . . . . . . . . 1841
G. Rupp and
E. O'Toole and
L. C. Gardner and
B. F. Mitchell and
M. E. Porter The sup-pf-$2$ mutations of
Chlamydomonas alter the activity of the
outer dynein arms by modification of the
gamma-dynein heavy chain . . . . . . . . 1853
S. Wahle and
W. Stoffel Membrane topology of the high-affinity
L-glutamate transporter (GLAST-1) of the
central nervous system . . . . . . . . . 1867
M. I. Morasso and
N. G. Markova and
T. D. Sargent Regulation of epidermal differentiation
by a Distal-less homeodomain gene . . . 1879
D. Schadendorf and
M. A. Kern and
M. Artuc and
H. L. Pahl and
T. Rosenbach and
I. Fichtner and
W. Nürnberg and
S. Stüting and
E. von Stebut and
M. Worm and
A. Makki and
K. Jurgovsky and
G. Kolde and
B. M. Henz Treatment of melanoma cells with the
synthetic retinoid CD437 induces
apoptosis via activation of AP-1 in
vitro, and causes growth inhibition in
xenografts in vivo . . . . . . . . . . . 1889
C. L. Adams and
W. J. Nelson and
S. J. Smith Quantitative analysis of
cadherin-catenin-actin reorganization
during development of cell--cell
adhesion . . . . . . . . . . . . . . . . 1899
M. Opas and
M. Szewczenko-Pawlikowski and
G. K. Jass and
N. Mesaeli and
M. Michalak Calreticulin modulates cell adhesiveness
via regulation of vinculin expression 1913
D. M. Glover and
H. Ohkura and
A. Tavares Polo kinase: the choreographer of the
mitotic stage? . . . . . . . . . . . . . 1681
Richard K. Assoian Anchorage-dependent Cell Cycle
Progression . . . . . . . . . . . . . . 1
Lei Du and
Stephen L. Warren A Functional Interaction between the
Carboxy--Terminal Domain of RNA
Polymerase II and Pre-mRNA Splicing . . 5
Euikyung Kim and
Lei Du and
David B. Bregman and
Stephen L. Warren Splicing Factors Associate with
Hyperphosphorylated RNA Polymerase II in
the Absence of Pre-mRNA . . . . . . . . 19
Paul R. Andreassen and
Françoise B. Lacroix and
Robert L. Margolis Chromosomes with Two Intact Axial Cores
Are Induced by G$_2$ Checkpoint
Override: Evidence That DNA Decatenation
Is not Required to Template the
Chromosome Structure . . . . . . . . . . 29
Agn\`es Saint-Pol and
Chantal Bauvy and
Patrice Codogno and
Stuart E. H. Moore Transfer of Free Polymannose-type
Oligosaccharides from the Cytosol to
Lysosomes in Cultured Human
Hepatocellular Carcinoma HEPG2 Cells . . 45
Willisa Liou and
Hans J. Geuze and
Math. J. H. Geelen and
Jan W. Slot The Autophagic and Endocytic Pathways
Converge at the Nascent Autophagic
Vacuoles . . . . . . . . . . . . . . . . 61
Erik A. C. Wiemer and
Thibaut Wenzel and
Thomas J. Deerinck and
Mark H. Ellisman and
Suresh Subramani Visualization of the Peroxisomal
Compartment in Living Mammalian Cells:
Dynamic Behavior and Association with
Microtubules . . . . . . . . . . . . . . 71
Leonid V. Chernomordik and
Eugenia Leikina and
Vadim Frolov and
Peter Bronk and
Joshua Zimmerberg An Early Stage of Membrane Fusion
Mediated by the Low pH Conformation of
Influenza Hemagglutinin Depends upon
Membrane Lipids . . . . . . . . . . . . 81
Beatriz Santos and
Michael Snyder Targeting of Chitin Synthase 3 to
Polarized Growth Sites in Yeast Requires
Chs5p and Myo2p . . . . . . . . . . . . 95
Shirley Yang and
Kathryn R. Ayscough and
David G. Drubin A Role for the Actin Cytoskeleton of
\bionameSaccharomyces cerevisiae in
Bipolar Bud--Site Selection . . . . . . 111
Hiro M. Mahbubani and
James P. J. Chong and
Stephane Chevalier and
Pia Thömmes and
J. Julian Blow Cell Cycle Regulation of the Replication
Licensing System: Involvement of a
Cdk-dependent Inhibitor . . . . . . . . 125
Robert G. Parton and
Michael Way and
Natasha Zorzi and
Espen Stang Caveolin-3 Associates with Developing
T-tubules during Muscle Differentiation 137
Elly M. Tanaka and
Alexander A. F. Gann and
Phillip B. Gates and
Jeremy P. Brockes Newt Myotubes Reenter the Cell Cycle by
Phosphorylation of the Retinoblastoma
Protein . . . . . . . . . . . . . . . . 155
Geoffrey Habermacher and
Winfield S. Sale Regulation of Flagellar Dynein by
Phosphorylation of a 138-kD Inner Arm
Dynein Intermediate Chain . . . . . . . 167
Stephen J. King and
Susan K. Dutcher Phosphoregulation of an Inner Dynein Arm
Complex in Chlamydomonas reinhardtii Is
Altered in Phototactic Mutant Strains 177
Yuji Nakajima and
Kohei Miyazono and
Mitsuyasu Kato and
Masao Takase and
Toshiyuki Yamagishi and
Hiroaki Nakamura Extracellular Fibrillar Structure of
Latent TGF$ \beta $ Binding Protein-1:
Role in TGF$ \beta $-dependent
Endothelial--Mesenchymal Transformation
during Endocardial Cushion Tissue
Formation in Mouse Embryonic Heart . . . 193
Michael Amling and
Lynn Neff and
Sakae Tanaka and
Daisuke Inoue and
Keisuke Kuida and
Eleanor Weir and
William M. Philbrick and
Arthur E. Broadus and
Roland Baron Bcl-2 Lies Downstream of Parathyroid
Hormone--related Peptide in a Signaling
Pathway That Regulates Chondrocyte
Maturation during Skeletal Development 205
Nicola J. McCarthy and
Moira K. B. Whyte and
Christopher S. Gilbert and
Gerard I. Evan Inhibition of Ced-3/ICE-related
Proteases Does Not Prevent Cell Death
Induced by Oncogenes, DNA Damage, or the
Bcl-2 Homologue Bak . . . . . . . . . . 215
Alexey Khodjakov and
Richard W. Cole and
Bruce F. McEwen and
Karolyn F. Buttle and
Conly L. Rieder Chromosome Fragments Possessing Only One
Kinetochore Can Congress to the Spindle
Equator . . . . . . . . . . . . . . . . 229
Maureen A. Powers and
Douglass J. Forbes and
James E. Dahlberg and
Elsebet Lund The Vertebrate GLFG Nucleoporin, Nup98,
Is an Essential Component of Multiple
RNA Export Pathways . . . . . . . . . . 241
Peng Chen and
Stephanie K. Sapperstein and
Jonathan D. Choi and
Susan Michaelis Biogenesis of the \bionameSaccharomyces
cerevisiae Mating Pheromone a--Factor 251
Konomi Fujimura-Kamada and
Franklin J. Nouvet and
Susan Michaelis A Novel Membrane-associated
Metalloprotease, Ste24p, Is Required for
the First Step of NH$_2$-terminal
Processing of the Yeast a-Factor
Precursor . . . . . . . . . . . . . . . 271
Nia J. Bryant and
Tom H. Stevens Two Separate Signals Act Independently
to Localize a Yeast Late Golgi Membrane
Protein through a Combination of
Retrieval and Retention . . . . . . . . 287
Zuoyu Xu and
Andreas Mayer and
Eric Muller and
William Wickner A Heterodimer of Thioredoxin and I$^B_2$
Cooperates with Sec18p (NSF) to Promote
Yeast Vacuole Inheritance . . . . . . . 299
Andreas Mayer and
William Wickner Docking of Yeast Vacuoles Is Catalyzed
by the Ras-like GTPase Ypt7p after
Symmetric Priming by Sec18p (NSF) . . . 307
Jean M. Wilson and
Tamara L. Colton Targeting of an Intestinal Apical
Endosomal Protein to Endosomes in
Nonpolarized Cells . . . . . . . . . . . 319
R. Dyche Mullins and
Walter F. Stafford and
Thomas D. Pollard Structure, Subunit Topology, and
Actin-binding Activity of the Arp2/3
Complex from \bionameAcanthamoeba . . . 331
Sam S. Yang and
Elaine Yeh and
E. D. Salmon and
Kerry Bloom Identification of a Mid-anaphase
Checkpoint in Budding Yeast . . . . . . 345
Paola Pizzo and
Cristina Fasolato and
Tullio Pozzan Dynamic Properties of an Inositol
1,4,5-Trisphosphate- and
Thapsigargin-insensitive Calcium Pool in
Mammalian Cell Lines . . . . . . . . . . 355
Richard L. Rotundo and
Susana G. Rossi and
Lili Anglister Transplantation of Quail Collagen-tailed
Acetylcholinesterase Molecules Onto the
Frog Neuromuscular Synapse . . . . . . . 367
Daniel J. Belliveau and
Irena Krivko and
Judi Kohn and
Christian Lachance and
Christine Pozniak and
Dmitri Rusakov and
David Kaplan and
Freda D. Miller NGF and Neurotrophin-3 Both Activate
TrkA on Sympathetic Neurons but
Differentially Regulate Survival and
Neuritogenesis . . . . . . . . . . . . . 375
Eleni Dicou and
Beth Pflug and
Marilyn Magazin and
Thér\`ese Lehy and
Daniel Djakiew and
Pascual Ferrara and
Véronique Nerri\`ere and
Douglas Harvie Two Peptides Derived from the Nerve
Growth Factor Precursor Are Biologically
Active . . . . . . . . . . . . . . . . . 389
Vivian Wong and
Barry M. Gumbiner A Synthetic Peptide Corresponding to the
Extracellular Domain of Occludin
Perturbs the Tight Junction Permeability
Barrier . . . . . . . . . . . . . . . . 399
Kris Vleminckx and
Ellen Wong and
Kathy Guger and
Bonnee Rubinfeld and
Paul Polakis and
Barry M. Gumbiner Adenomatous Polyposis Coli Tumor
Suppressor Protein Has Signaling
Activity in \bionameXenopus laevis
Embryos Resulting in the Induction of an
Ectopic Dorsoanterior Axis . . . . . . . 411
Laura Airas and
Jussi Niemelä and
Marko Salmi and
Tarja Puurunen and
David J. Smith and
Sirpa Jalkanen Differential Regulation and Function of
CD73, a
Glycosyl--Phosphatidylinositol--linked
70-kD Adhesion Molecule, on Lymphocytes
and Endothelial Cells . . . . . . . . . 421
Rong-Rong Wu and
John R. Couchman cDNA Cloning of the Basement Membrane
Chondroitin Sulfate Proteoglycan Core
Protein, Bamacan: a Five Domain
Structure Including Coiled--Coil Motifs 433
David E. Cash and
Cheryl B. Bock and
Klaus Schughart and
Elwood Linney and
T. Michael Underhill Retinoic Acid Receptor $ \alpha $
Function in Vertebrate Limb
Skeletogenesis: a Modulator of
Chondrogenesis . . . . . . . . . . . . . 445
Kin Ming Kwan and
Michael K. M. Pang and
Sheila Zhou and
Soot Keng Cowan and
Richard Y. C. Kong and
Tim Pfordte and
Bjorn R. Olsen and
David O. Sillence and
Patrick P. L. Tam and
Kathryn S. E. Cheah Abnormal Compartmentalization of
Cartilage Matrix Components in Mice
Lacking Collagen X: Implications for
Function . . . . . . . . . . . . . . . . 459
Jiahua Xu and
Richard A. F. Clark A Three-dimensional Collagen Lattice
Induces Protein Kinase C-$ \zeta $
Activity: Role in $ \alpha_2 $ Integrin
and Collagenase mRNA Expression . . . . 473
Dana Halverson and
Mary Baum and
Janet Stryker and
John Carbon and
Louise Clarke A Centromere DNA-binding Protein from
Fission Yeast Affects Chromosome
Segregation and Has Homology to Human
CENP--B . . . . . . . . . . . . . . . . 487
Richard D. Shelby and
Omid Vafa and
Kevin F. Sullivan Assembly of CENP--A into Centromeric
Chromatin Requires a Cooperative Array
of Nucleosomal DNA Contact Sites . . . . 501
Volker C. Cordes and
Sonja Reidenbach and
Hans-Richard Rackwitz and
Werner W. Franke Identification of Protein p270/Tpr as a
Constitutive Component of the Nuclear
Pore Complex--attached Intranuclear
Filaments . . . . . . . . . . . . . . . 515
Mark Fricker and
Michael Hollinshead and
Nick White and
David Vaux Interphase Nuclei of Many Mammalian Cell
Types Contain Deep, Dynamic, Tubular
Membrane-bound Invaginations of the
Nuclear Envelope . . . . . . . . . . . . 531
Karen H. Berger and
L. Farah Sogo and
Michael P. Yaffe Mdm12p, a Component Required for
Mitochondrial Inheritance That Is
Conserved between Budding and Fission
Yeast . . . . . . . . . . . . . . . . . 545
Utpal Tatu and
Ari Helenius Interactions between Newly Synthesized
Glycoproteins, Calnexin and a Network of
Resident Chaperones in the Endoplasmic
Reticulum . . . . . . . . . . . . . . . 555
Jaisri R. Lingappa and
Rebecca L. Hill and
Mei Lie Wong and
Ramanujan S. Hegde A Multistep, ATP-dependent Pathway for
Assembly of Human Immunodeficiency Virus
Capsids in a Cell-free System . . . . . 567
Agathe Subtil and
Muriel Delepierre and
Alice Dautry-Varsat An $ \alpha $-Helical Signal in the
Cytosolic Domain of the Interleukin 2
Receptor $ \beta $ Chain Mediates
Sorting Towards Degradation after
Endocytosis . . . . . . . . . . . . . . 583
Christian Erxleben and
Norbert Klauke and
Matthias Flötenmeyer and
Marie-Pierre Blanchard and
Claudia Braun and
Helmut Plattner Microdomain Ca$^{2+}$ Activation during
Exocytosis in Paramecium Cells.
Superposition of Local Subplasmalemmal
Calcium Store Activation by Local
Ca$^{2+}$ Influx . . . . . . . . . . . . 597
Barbara A. Burleigh and
Elisabet V. Caler and
Paul Webster and
Norma W. Andrews A Cytosolic Serine Endopeptidase from
Trypanosoma cruzi Is Required for the
Generation of Ca$^{2+}$ Signaling in
Mammalian Cells . . . . . . . . . . . . 609
Daixing Zhou and
Connie S. Birkenmeier and
McRae W. Williams and
John J. Sharp and
Jane E. Barker and
Robert J. Bloch Small, Membrane-bound, Alternatively
Spliced Forms of Ankyrin 1 Associated
with the Sarcoplasmic Reticulum of
Mammalian Skeletal Muscle . . . . . . . 621
Kristine D. Novak and
Margaret A. Titus Myosin I Overexpression Impairs Cell
Migration . . . . . . . . . . . . . . . 633
Rong Li Bee1, a Yeast Protein with Homology to
Wiscott--Aldrich Syndrome Protein, Is
Critical for the Assembly of Cortical
Actin Cytoskeleton . . . . . . . . . . . 649
Wenqian Yu and
David J. Sharp and
Ryoko Kuriyama and
Prabhat Mallik and
Peter W. Baas Inhibition of a Mitotic Motor
Compromises the Formation of
Dendrite-like Processes from
Neuroblastoma Cells . . . . . . . . . . 659
Eunjoon Kim and
Scott Naisbitt and
Yi-Ping Hsueh and
Anuradha Rao and
Adam Rothschild and
Ann Marie Craig and
Morgan Sheng GKAP, a Novel Synaptic Protein That
Interacts with the Guanylate Kinase-like
Domain of the PSD-95/SAP90 Family of
Channel Clustering Molecules . . . . . . 669
Pico Caroni and
Ludwig Aigner and
Corinna Schneider Intrinsic Neuronal Determinants Locally
Regulate Extrasynaptic and Synaptic
Growth at the Adult Neuromuscular
Junction . . . . . . . . . . . . . . . . 679
Angela I. M. Barth and
Anne L. Pollack and
Yoram Altschuler and
Keith E. Mostov and
W. James Nelson NH$_2$-terminal Deletion of $ \beta
$-Catenin Results in Stable
Colocalization of Mutant $ \beta
$-Catenin with Adenomatous Polyposis
Coli Protein and Altered MDCK Cell
Adhesion . . . . . . . . . . . . . . . . 693
Olaf Zöllner and
Martin C. Lenter and
James E. Blanks and
Eric Borges and
Martin Steegmaier and
Hans-Günther Zerwes and
Dietmar Vestweber L-Selectin from Human, but Not from
Mouse Neutrophils Binds Directly to
E--Selectin . . . . . . . . . . . . . . 707
Michael B. Lawrence and
Geoffrey S. Kansas and
Eric J. Kunkel and
Klaus Ley Threshold Levels of Fluid Shear Promote
Leukocyte Adhesion through Selectins
(CD62L,P,E) . . . . . . . . . . . . . . 717
Keith G. Danielson and
Helene Baribault and
David F. Holmes and
Helen Graham and
Karl E. Kadler and
Renato V. Iozzo Targeted Disruption of Decorin Leads to
Abnormal Collagen Fibril Morphology and
Skin Fragility . . . . . . . . . . . . . 729
Na\"\ima Belgareh and
Valérie Doye Dynamics of Nuclear Pore Distribution in
Nucleoporin Mutant Yeast Cells . . . . . 747
Vladimir I. Bashkirov and
Harry Scherthan and
Jachen A. Solinger and
Jean-Marie Buerstedde and
Wolf-Dietrich Heyer A Mouse Cytoplasmic Exoribonuclease
(mXRN1p) with Preference for G4
Tetraplex Substrates . . . . . . . . . . 761
Kay N. Meyer and
Eigil Kjeldsen and
Tobias Straub and
Birgitta R. Knudsen and
Ian D. Hickson and
Akihiko Kikuchi and
Hans Kreipe and
Fritz Boege Cell Cycle--coupled Relocation of Types
I and II Topoisomerases and Modulation
of Catalytic Enzyme Activities . . . . . 775
Erin C. Gaynor and
Scott D. Emr COPI-independent Anterograde Transport:
Cargo-selective ER to Golgi Protein
Transport in Yeast COPI Mutants . . . . 789
Pei-Hsin Huang and
Hui-Ling Chiang Identification of Novel Vesicles in the
Cytosol to Vacuole Protein Degradation
Pathway . . . . . . . . . . . . . . . . 803
Sanne van Delft and
Christopher Schumacher and
Willem Hage and
Arie J. Verkleij and
Paul M. P. van Bergen en Henegouwen Association and Colocalization of Eps15
with Adaptor Protein-2 and Clathrin . . 811
Ralph Henry and
Matthew Carrigan and
Michael McCaffery and
Xianyue Ma and
Kenneth Cline Targeting Determinants and Proposed
Evolutionary Basis for the Sec and the
Delta pH Protein Transport Systems in
Chloroplast Thylakoid Membranes . . . . 823
Donner F. Babcock and
James Herrington and
Paul C. Goodwin and
Young Bae Park and
Bertil Hille Mitochondrial Participation in the
Intracellular Ca$^{2+}$ Network . . . . 833
C. Casey Cunningham and
Nicole Leclerc and
Lisa A. Flanagan and
Mei Lu and
Paul A. Janmey and
Kenneth S. Kosik Microtubule-associated Protein 2c
Reorganizes Both Microtubules and
Microfilaments into Distinct Cytological
Structures in an Actin-binding
Protein-280--deficient Melanoma Cell
Line . . . . . . . . . . . . . . . . . . 845
Claire E. Walczak and
Suzie Verma and
Timothy J. Mitchison XCTK2: a Kinesin-related Protein That
Promotes Mitotic Spindle Assembly in
\bionameXenopus laevis Egg Extracts . . 859
R. Mark Grady and
John P. Merlie and
Joshua R. Sanes Subtle Neuromuscular Defects in
Utrophin-deficient Mice . . . . . . . . 871
Anne E. Deconinck and
Allyson C. Potter and
Jonathon M. Tinsley and
Sarah J. Wood and
Ruth Vater and
Carol Young and
Laurent Metzinger and
Angela Vincent and
Clarke R. Slater and
Kay E. Davies Postsynaptic Abnormalities at the
Neuromuscular Junctions of
Utrophin-deficient Mice . . . . . . . . 883
Stefan Schumacher and
Hansjürgen Volkmer and
Fritz Buck and
Albrecht Otto and
Attila Tárnok and
Siegfried Roth and
Fritz G. Rathjen Chicken Acidic Leucine-rich EGF-like
Domain Containing Brain Protein (CALEB),
a Neural Member of the EGF Family of
Differentiation Factors, Is Implicated
in Neurite Formation . . . . . . . . . . 895
Takeshi Sakurai and
Marc Lustig and
Moshe Nativ and
John J. Hemperly and
Joseph Schlessinger and
Elior Peles and
Martin Grumet Induction of Neurite Outgrowth through
Contactin and Nr--CAM by Extracellular
Regions of Glial Receptor Tyrosine
Phosphatase $ \beta $ . . . . . . . . . 907
Jani E. Lewis and
James K. Wahl and
Kristin M. Sass and
Pamela J. Jensen and
Keith R. Johnson and
Margaret J. Wheelock Cross-Talk between Adherens Junctions
and Desmosomes Depends on Plakoglobin 919
Christine Sers and
Urban Emmenegger and
Knut Husmann and
Katharina Bucher and
Ann-Catherine Andres and
Reinhold Schäfer Growth-inhibitory Activity and
Downregulation of the Class II
Tumor-suppressor Gene H-rev107 in Tumor
Cell Lines and Experimental Tumors . . . 935
Laura Giuffr\`e and
Anne-Sophie Cordey and
Natacha Monai and
Yanik Tardy and
Marc Schapira and
Olivier Spertini Monocyte Adhesion to Activated Aortic
Endothelium: Role of L--Selectin and
Heparan Sulfate Proteoglycans . . . . . 945
Albert V. Smith and
G. Shirleen Roeder The Yeast Red1 Protein Localizes to the
Cores of Meiotic Chromosomes . . . . . . 957
Amy R. Schutz and
Thomas H. Giddings and
Estelle Steiner and
Mark Winey The Yeast CDC37 Gene Interacts with MPS1
and Is Required for Proper Execution of
Spindle Pole Body Duplication . . . . . 969
Mitsuru Akita and
Erik Nielsen and
Kenneth Keegstra Identification of Protein Transport
Complexes in the Chloroplastic Envelope
Membranes via Chemical Cross--Linking 983
Grigory B. Melikyan and
Sofya A. Brener and
Dong C. Ok and
Fredric S. Cohen Inner but Not Outer Membrane Leaflets
Control the Transition from
Glycosylphosphatidylinositol-anchored
Influenza Hemagglutinin-induced
Hemifusion to Full Fusion . . . . . . . 995
Beate Sodeik and
Melanie W. Ebersold and
Ari Helenius Microtubule-mediated Transport of
Incoming Herpes Simplex Virus 1 Capsids
to the Nucleus . . . . . . . . . . . . . 1007
Wouter van 't Hof and
Marilyn D. Resh Rapid Plasma Membrane Anchoring of Newly
Synthesized p59$^{\rm fyn}$: Selective
Requirement for NH$_2$-Terminal
Myristoylation and Palmitoylation at
Cysteine-3 . . . . . . . . . . . . . . . 1023
Theodore M. Shih and
Alan L. Goldin Topology of the Shaker Potassium Channel
Probed with Hydrophilic Epitope
Insertions . . . . . . . . . . . . . . . 1037
Monroe W. Cohen and
Christian Jacobson and
Peter D. Yurchenco and
Glenn E. Morris and
Salvatore Carbonetto Laminin-induced Clustering of
Dystroglycan on Embryonic Muscle Cells:
Comparison with Agrin-induced Clustering 1047
Thomas C. Hoock and
Luanne L. Peters and
Samuel E. Lux Isoforms of Ankyrin-3 That Lack the
NH$_2$-terminal Repeats Associate with
Mouse Macrophage Lysosomes . . . . . . . 1059
Alice D. Ma and
Lawrence F. Brass and
Charles S. Abrams Pleckstrin Associates with Plasma
Membranes and Induces the Formation of
Membrane Projections: Requirements for
Phosphorylation and the NH$_2$-terminal
PH Domain . . . . . . . . . . . . . . . 1071
Andrea J. Pereira and
Brian Dalby and
Russell J. Stewart and
Stephen J. Doxsey and
Lawrence S. B. Goldstein Mitochondrial Association of a Plus
End--Directed Microtubule Motor
Expressed during Mitosis in
\bionameDrosophila . . . . . . . . . . . 1081
Katsuya Takenaka and
Yukiko Gotoh and
Eisuke Nishida MAP Kinase Is Required for the Spindle
Assembly Checkpoint but Is Dispensable
for the Normal M Phase Entry and Exit in
\bionameXenopus Egg Cell Cycle Extracts 1091
Jingdong Tian and
Hui Gong and
Gerald H. Thomsen and
William J. Lennarz Gamete Interactions in \bionameXenopus
laevis: Identification of Sperm Binding
Glycoproteins in the Egg Vitelline
Envelope . . . . . . . . . . . . . . . . 1099
Bertolt Kreft and
Dietmar Berndorff and
Anja Böttinger and
Silvia Finnemann and
Doris Wedlich and
Michael Hortsch and
Rudolf Tauber and
Reinhard Geßner LI-Cadherin-mediated Cell--Cell Adhesion
Does Not Require Cytoplasmic
Interactions . . . . . . . . . . . . . . 1109
Carolyn A. Larabell and
Monica Torres and
Brian A. Rowning and
Cynthia Yost and
Jeffrey R. Miller and
Mike Wu and
David Kimelman and
Randall T. Moon Establishment of the Dorso-ventral Axis
in \bionameXenopus Embryos Is Presaged
by Early Asymmetries in $ \beta
$-Catenin That Are Modulated by the Wnt
Signaling Pathway . . . . . . . . . . . 1123
Katsutoshi Furukawa and
Steven Estus and
Weiming Fu and
Robert J. Mark and
Mark P. Mattson Neuroprotective Action of Cycloheximide
Involves Induction of Bcl-2 and
Antioxidant Pathways . . . . . . . . . . 1137
Irene Nunes and
Pierre-Emmanuel Gleizes and
Christine N. Metz and
Daniel B. Rifkin Latent Transforming Growth Factor-$
\beta $ Binding Protein Domains Involved
in Activation and
Transglutaminase-dependent
Cross--Linking of Latent Transforming
Growth Factor-$ \beta $ . . . . . . . . 1151
Julie A. Theriot Accelerating on a Treadmill: ADF/Cofilin
Promotes Rapid Actin Filament Turnover
in the Dynamic Cytoskeleton . . . . . . 1165
D. Mark Eckley and
Alexandra M. Ainsztein and
Alastair M. Mackay and
Ilya G. Goldberg and
William C. Earnshaw Chromosomal Proteins and Cytokinesis:
Patterns of Cleavage Furrow Formation
and Inner Centromere Protein Positioning
in Mitotic Heterokaryons and
Mid-anaphase Cells . . . . . . . . . . . 1169
Mirella Bucci and
Susan R. Wente In Vivo Dynamics of Nuclear Pore
Complexes in Yeast . . . . . . . . . . . 1185
Timothy P. Spann and
Robert D. Moir and
Anne E. Goldman and
Reimer Stick and
Robert D. Goldman Disruption of Nuclear Lamin Organization
Alters the Distribution of Replication
Factors and Inhibits DNA Synthesis . . . 1201
Edwin C. Murphy and
Tianli Zheng and
Christopher V. Nicchitta Identification of a Novel Stage of
Ribosome/Nascent Chain Association with
the Endoplasmic Reticulum Membrane . . . 1213
Amitabha Mukhopadhyay and
Alejandro M. Barbieri and
Kouichi Funato and
Richard Roberts and
Philip D. Stahl Sequential Actions of Rab5 and Rab7
Regulate Endocytosis in the
\bionameXenopus Oocyte . . . . . . . . . 1227
Jun Katahira and
Norimitsu Inoue and
Yasuhiko Horiguchi and
Morihiro Matsuda and
Nakaba Sugimoto Molecular Cloning and Functional
Characterization of the Receptor for
Clostridium perfringens Enterotoxin . . 1239
Stephen K. Doberstein and
Richard D. Fetter and
Anand Y. Mehta and
Corey S. Goodman Genetic Analysis of Myoblast Fusion:
blown fuse Is Required for Progression
Beyond the Prefusion Complex . . . . . . 1249
Edward H. Kislauskis and
Xiao-chun Zhu and
Robert H. Singer $ \beta $-Actin Messenger RNA
Localization and Protein Synthesis
Augment Cell Motility . . . . . . . . . 1263
Greg Buczynski and
Bryon Grove and
Anson Nomura and
Maurice Kleve and
John Bush and
Richard A. Firtel and
James Cardelli Inactivation of Two
\bionameDictyostelium discoideum Genes,
DdPIK1 and DdPIK2, Encoding Proteins
Related to Mammalian
Phosphatidylinositide $3$-kinases,
Results in Defects in Endocytosis,
Lysosome to Postlysosome Transport, and
Actin Cytoskeleton Organization . . . . 1271
Louise P. Cramer and
Margaret Siebert and
Timothy J. Mitchison Identification of Novel Graded Polarity
Actin Filament Bundles in Locomoting
Heart Fibroblasts: Implications for the
Generation of Motile Force . . . . . . . 1287
Marie-France Carlier and
Valérie Laurent and
Jérôme Santolini and
Ronald Melki and
Dominique Didry and
Gui-Xian Xia and
Yan Hong and
Nam-Hai Chua and
Dominique Pantaloni Actin Depolymerizing Factor
(ADF/Cofilin) Enhances the Rate of
Filament Turnover: Implication in
Actin-based Motility . . . . . . . . . . 1307
Jody Rosenblatt and
Brian J. Agnew and
Hiroshi Abe and
James R. Bamburg and
Timothy J. Mitchison \bionameXenopus Actin Depolymerizing
Factor/Cofilin (XAC) Is Responsible for
the Turnover of Actin Filaments in
\bionameListeria monocytogenes Tails . . 1323
Luca Borradori and
Peter J. Koch and
Carien M. Niessen and
Stefan Erkeland and
Manuel R. van Leusden and
Arnoud Sonnenberg The Localization of Bullous Pemphigoid
Antigen 180 (BP180) in Hemidesmosomes Is
Mediated by Its Cytoplasmic Domain and
Seems to be Regulated by the $ \beta $4
Integrin Subunit . . . . . . . . . . . . 1333
Su Hao Lo and
Qian-Chun Yu and
Linda Degenstein and
Lan Bo Chen and
Elaine Fuchs Progressive Kidney Degeneration in Mice
Lacking Tensin . . . . . . . . . . . . . 1349
Brigitte Lelongt and
Germain Trugnan and
Gillian Murphy and
Pierre M. Ronco Matrix Metalloproteinases MMP2 and MMP9
Are Produced in Early Stages of Kidney
Morphogenesis but Only MMP9 Is Required
for Renal Organogenesis In Vitro . . . . 1363
Mariella F. Carlevaro and
Adriana Albini and
Domenico Ribatti and
Chiara Gentili and
Roberto Benelli and
Silvia Cermelli and
Ranieri Cancedda and
Fiorella Descalzi Cancedda Transferrin Promotes Endothelial Cell
Migration and Invasion: Implication in
Cartilage Neovascularization . . . . . . 1375
Tsung H. Lin and
Andrew E. Aplin and
Yu Shen and
Qiming Chen and
Michael Schaller and
Lewis Romer and
Ikramuddin Aukhil and
R. L. Juliano Integrin-mediated Activation of MAP
Kinase Is Independent of FAK: Evidence
for Dual Integrin Signaling Pathways in
Fibroblasts . . . . . . . . . . . . . . 1385
Paul L. McNeil and
Richard A. Steinhardt Loss, Restoration, and Maintenance of
Plasma Membrane Integrity . . . . . . . 1
Hank W. Bass and
Wallace F. Marshall and
John W. Sedat and
David A. Agard and
W. Zacheus Cande Telomeres Cluster De Novo before the
Initiation of Synapsis: a
Three-dimensional Spatial Analysis of
Telomere Positions before and during
Meiotic Prophase . . . . . . . . . . . . 5
Luca Falciola and
Fabio Spada and
Sabina Calogero and
Gernot Längst and
Renate Voit and
Ingrid Grummt and
Marco E. Bianchi High Mobility Group 1 Protein Is Not
Stably Associated with the Chromosomes
of Somatic Cells . . . . . . . . . . . . 19
Elisa Izaurralde and
Artur Jarmolowski and
Christina Beisel and
Iain W. Mattaj and
Gideon Dreyfuss and
Utz Fischer A Role for the M9 Transport Signal of
hnRNP A1 in mRNA Nuclear Export . . . . 27
Steven Bassnett and
Danijela Mataic Chromatin Degradation in Differentiating
Fiber Cells of the Eye Lens . . . . . . 37
Valérie Brachet and
Graça Raposo and
Sebastian Amigorena and
Ira Mellman Ii Chain Controls the Transport of Major
Histocompatibility Complex Class II
Molecules to and from Lysosomes . . . . 51
Akiko Okada and
Catherine Tomasetto and
Yves Lutz and
Jean-Pierre Bellocq and
Marie-Christine Rio and
Paul Basset Expression of Matrix Metalloproteinases
during Rat Skin Wound Healing: Evidence
that Membrane Type-1 Matrix
Metalloproteinase Is a Stromal Activator
of Pro--Gelatinase A . . . . . . . . . . 67
Matthew N. J. Seaman and
Eric G. Marcusson and
Joan Lin Cereghino and
Scott D. Emr Endosome to Golgi Retrieval of the
Vacuolar Protein Sorting Receptor,
Vps10p, Requires the Function of the
VPS29, VPS30, and VPS35 Gene Products 79
Ana Rodríguez and
Paul Webster and
Javier Ortego and
Norma W. Andrews Lysosomes Behave as Ca$^{2+}$-regulated
Exocytic Vesicles in Fibroblasts and
Epithelial Cells . . . . . . . . . . . . 93
Ruiyong Yuan and
Paul Primakoff and
Diana G. Myles A Role for the Disintegrin Domain of
Cyritestin, a Sperm Surface Protein
Belonging to the ADAM Family, in Mouse
Sperm--Egg Plasma Membrane Adhesion and
Fusion . . . . . . . . . . . . . . . . . 105
Ariel Blocker and
Fedor F. Severin and
Janis K. Burkhardt and
James B. Bingham and
Hanry Yu and
Jean-Christophe Olivo and
Trina A. Schroer and
Anthony A. Hyman and
Gareth Griffiths Molecular Requirements for
Bi-directional Movement of Phagosomes
Along Microtubules . . . . . . . . . . . 113
K. David Becker and
Kim R. Gottshall and
Reed Hickey and
Jean-Claude Perriard and
Kenneth R. Chien Point Mutations in Human $ \beta $
Cardiac Myosin Heavy Chain Have
Differential Effects on Sarcomeric
Structure and Assembly: an ATP Binding
Site Change Disrupts Both Thick and Thin
Filaments, Whereas Hypertrophic
Cardiomyopathy Mutations Display Normal
Assembly . . . . . . . . . . . . . . . . 131
Greg J. Hermann and
Edward J. King and
Janet M. Shaw The Yeast Gene, MDM20, Is Necessary for
Mitochondrial Inheritance and
Organization of the Actin Cytoskeleton 141
Antonio S. Sechi and
Jürgen Wehland and
J. Victor Small The Isolated Comet Tail Pseudopodium of
\bionameListeria monocytogenes: a Tail
of Two Actin Filament Populations, Long
and Axial and Short and Random . . . . . 155
Fred Chang and
David Drubin and
Paul Nurse cdc12p, a Protein Required for
Cytokinesis in Fission Yeast, Is a
Component of the Cell Division Ring and
Interacts with Profilin . . . . . . . . 169
Xuequn Helen Hua and
Hong Yan and
John Newport A Role for Cdk2 Kinase in Negatively
Regulating DNA Replication during S
Phase of the Cell Cycle . . . . . . . . 183
Jacalyn M. Vogel and
Tim Stearns and
Conly L. Rieder and
Robert E. Palazzo Centrosomes Isolated from Spisula
solidissima Oocytes Contain Rings and an
Unusual Stoichiometric Ratio of $ \alpha
$ /$ \beta $ Tubulin . . . . . . . . . . 193
Han-qing Xie and
Dale W. Laird and
Tsg-Hui Chang and
Valerie W. Hu A Mitosis-specific Phosphorylation of
the Gap Junction Protein Connexin43 in
Human Vascular Cells: Biochemical
Characterization and Localization . . . 203
Timothy Vartanian and
Andrew Goodearl and
Andrea Viehöver and
Gerald Fischbach Axonal Neuregulin Signals Cells of the
Oligodendrocyte Lineage through
Activation of HER4 and Schwann Cells
through HER2 and HER3 . . . . . . . . . 211
Sara M. Mariani and
Bernd Matiba and
Elena A. Armandola and
Peter H. Krammer Interleukin 1$ \beta $-converting Enzyme
Related Proteases/Caspases Are Involved
in TRAIL-induced Apoptosis of Myeloma
and Leukemia Cells . . . . . . . . . . . 221
V. M. Weaver and
O. W. Petersen and
F. Wang and
C. A. Larabell and
P. Briand and
C. Damsky and
M. J. Bissell Reversion of the Malignant Phenotype of
Human Breast Cells in Three--Dimensional
Culture and In Vivo by Integrin Blocking
Antibodies . . . . . . . . . . . . . . . 231
Yousef Abu-Amer and
F. Patrick Ross and
Paul Schlesinger and
M. Mehrdad Tondravi and
Steven L. Teitelbaum Substrate Recognition by Osteoclast
Precursors Induces C-src/Microtubule
Association . . . . . . . . . . . . . . 247
Jose C. Reyes and
Christian Muchardt and
Moshe Yaniv Components of the Human SWI/SNF Complex
Are Enriched in Active Chromatin and Are
Associated with the Nuclear Matrix . . . 263
Sharon Wald Krauss and
Carolyn A. Larabell and
Stephen Lockett and
Philippe Gascard and
Sheldon Penman and
Narla Mohandas and
Joel Anne Chasis Structural Protein 4.1 in the Nucleus of
Human Cells: Dynamic Rearrangements
during Cell Division . . . . . . . . . . 275
Peter Buchenau and
Harald Saumweber and
Donna J. Arndt-Jovin The Dynamic Nuclear Redistribution of an
hnRNP K-homologous Protein during
\bionameDrosophila Embryo Development
and Heat Shock. Flexibility of
Transcription Sites In Vivo . . . . . . 291
Armin Rehm and
Hidde L. Ploegh Assembly and Intracellular Targeting of
the $ \beta \gamma $ Subunits of
Heterotrimeric G Proteins . . . . . . . 305
Jochen Scheel and
Rainer Pepperkok and
Martin Lowe and
Gareth Griffiths and
Thomas E. Kreis Dissociation of Coatomer from Membranes
Is Required for Brefeldin A--induced
Transfer of Golgi Enzymes to the
Endoplasmic Reticulum . . . . . . . . . 319
Roland Le Borgne and
Bernard Hoflack Mannose 6-Phosphate Receptors Regulate
the Formation of Clathrin-coated
Vesicles in the TGN . . . . . . . . . . 335
Sven C. D. van IJzendoorn and
Mirjam M. P. Zegers and
Jan Willem Kok and
Dick Hoekstra Segregation of Glucosylceramide and
Sphingomyelin Occurs in the Apical to
Basolateral Transcytotic Route in HepG2
Cells . . . . . . . . . . . . . . . . . 347
Pedro J. I. Salas and
Marcelo L. Rodriguez and
Ana L. Viciana and
Dora E. Vega-Salas and
Hans-Peter Hauri The Apical Submembrane Cytoskeleton
Participates in the Organization of the
Apical Pole in Epithelial Cells . . . . 359
Timothy A. Lohret and
Robert E. Jensen and
Kathleen W. Kinnally Tim23, a Protein Import Component of the
Mitochondrial Inner Membrane, Is
Required for Normal Activity of the
Multiple Conductance Channel, MCC . . . 377
Frits Michiels and
Jord C. Stam and
Peter L. Hordijk and
Rob A. van der Kammen and
Lisette Ruuls-Van Stalle and
Constance A. Feltkamp and
John G. Collard Regulated Membrane Localization of
Tiam1, Mediated by the NH$_2$-terminal
Pleckstrin Homology Domain, Is Required
for Rac-dependent Membrane Ruffling and
C--Jun NH$_2$-terminal Kinase Activation 387
Kathryn R. Ayscough and
Joel Stryker and
Navin Pokala and
Miranda Sanders and
Phil Crews and
David G. Drubin High Rates of Actin Filament Turnover in
Budding Yeast and Roles for Actin in
Establishment and Maintenance of Cell
Polarity Revealed Using the Actin
Inhibitor Latrunculin--A . . . . . . . . 399
William Saunders and
David Hornack and
Valerie Lengyel and
Changchun Deng The \bionameSaccharomyces cerevisiae
Kinesin-related Motor Kar3p Acts at
Preanaphase Spindle Poles to Limit the
Number and Length of Cytoplasmic
Microtubules . . . . . . . . . . . . . . 417
Xiao Min Wang and
Ye Zhai and
James E. Ferrell A Role for Mitogen-activated Protein
Kinase in the Spindle Assembly
Checkpoint in XTC Cells . . . . . . . . 433
Anne Schmidt and
Matthew J. Hannah and
Wieland B. Huttner Synaptic-like Microvesicles of
Neuroendocrine Cells Originate from a
Novel Compartment That Is Continuous
with the Plasma Membrane and Devoid of
Transferrin Receptor . . . . . . . . . . 445
Bruce D. Trapp and
Akiko Nishiyama and
David Cheng and
Wendy Macklin Differentiation and Death of
Premyelinating Oligodendrocytes in
Developing Rodent Brain . . . . . . . . 459
Marion MacFarlane and
Kelvin Cain and
Xiao-Ming Sun and
Emad S. Alnemri and
Gerald M. Cohen Processing\slash Activation of At Least
Four Interleukin-1$ \beta $ Converting
Enzyme-like Proteases Occurs during the
Execution Phase of Apoptosis in Human
Monocytic Tumor Cells . . . . . . . . . 469
Richard L. Klemke and
Shuang Cai and
Ana L. Giannini and
Patricia J. Gallagher and
Primal de Lanerolle and
David A. Cheresh Regulation of Cell Motility by
Mitogen-activated Protein Kinase . . . . 481
Miguel Angel del Pozo and
Carlos Cabañas and
María C. Montoya and
Ann Ager and
Paloma Sánchez-Mateos and
Francisco Sánchez-Madrid ICAMs Redistributed by Chemokines to
Cellular Uropods as a Mechanism for
Recruitment of T Lymphocytes . . . . . . 493
Douglas J. Goetz and
Daniel M. Greif and
Han Ding and
Raymond T. Camphausen and
Steven Howes and
Kenneth M. Comess and
Karen R. Snapp and
Geoffrey S. Kansas and
Francis W. Luscinskas Isolated P-selectin Glycoprotein
Ligand-1 Dynamic Adhesion to P- and
E-selectin . . . . . . . . . . . . . . . 509
Jun Yang and
Jimin Liu and
Donald B. DeFranco Subnuclear Trafficking of Glucocorticoid
Receptors In Vitro: Chromatin Recycling
and Nuclear Export . . . . . . . . . . . 523
Heather B. McDonald and
Breck Byers A Proteasome Cap Subunit Required for
Spindle Pole Body Duplication in Yeast 539
Johanna M. Wahlberg and
Martin Spiess Multiple Determinants Direct the
Orientation of Signal--Anchor Proteins:
The Topogenic Role of the Hydrophobic
Signal Domain . . . . . . . . . . . . . 555
Gregory Jedd and
Jon Mulholland and
Nava Segev Two New Ypt GTPases Are Required for
Exit From the Yeast trans -Golgi
Compartment . . . . . . . . . . . . . . 563
Ellen J. Tisdale and
Helen Plutner and
Jeanne Matteson and
William E. Balch p53/58 Binds COPI and Is Required for
Selective Transport through the Early
Secretory Pathway . . . . . . . . . . . 581
Regina Kuliawat and
Judith Klumperman and
Thomas Ludwig and
Peter Arvan Differential Sorting of Lysosomal
Enzymes Out of the Regulated Secretory
Pathway in Pancreatic $ \beta $-Cells 595
John Kim and
Sidney V. Scott and
Michael N. Oda and
Daniel J. Klionsky Transport of a Large Oligomeric Protein
by the Cytoplasm to Vacuole Protein
Targeting Pathway . . . . . . . . . . . 609
Lucinda I. Chen and
Melanie K. Webster and
April N. Meyer and
Daniel J. Donoghue Transmembrane Domain Sequence
Requirements for Activation of the
p185$^{c - neu}$ Receptor Tyrosine
Kinase . . . . . . . . . . . . . . . . . 619
Markus Hoth and
Christopher M. Fanger and
Richard S. Lewis Mitochondrial Regulation of
Store-operated Calcium Signaling in T
Lymphocytes . . . . . . . . . . . . . . 633
Takako Kato-Minoura and
Masafumi Hirono and
Ritsu Kamiya Chlamydomonas Inner--Arm Dynein Mutant,
ida5, Has a Mutation in an
Actin-encoding Gene . . . . . . . . . . 649
Zhao-hui Yang and
G. Ian Gallicano and
Qian-Chun Yu and
Elaine Fuchs An Unexpected Localization of Basonuclin
in the Centrosome, Mitochondria, and
Acrosome of Developing Spermatids . . . 657
Alain J. Denzer and
Ralph Brandenberger and
Matthias Gesemann and
Matthias Chiquet and
Markus A. Ruegg Agrin Binds to the Nerve--Muscle Basal
Lamina via Laminin . . . . . . . . . . . 671
Jeffrey H. Miner and
Bruce L. Patton and
Stephen I. Lentz and
Debra J. Gilbert and
William D. Snider and
Nancy A. Jenkins and
Neal G. Copeland and
Joshua R. Sanes The Laminin $ \alpha $ Chains:
Expression, Developmental Transitions,
and Chromosomal Locations of $ \alpha
$1-5, Identification of Heterotrimeric
Laminins 8--11, and Cloning of a Novel $
\alpha $3 Isoform . . . . . . . . . . . 685
Timothy D. Garver and
Qun Ren and
Shmuel Tuvia and
Vann Bennett Tyrosine Phosphorylation at a Site
Highly Conserved in the L1 Family of
Cell Adhesion Molecules Abolishes
Ankyrin Binding and Increases Lateral
Mobility of Neurofascin . . . . . . . . 703
Stefan Magez and
Maurice Geuskens and
Alain Beschin and
Herwig del Favero and
Hendrik Verschueren and
Ralf Lucas and
Etienne Pays and
Patrick de Baetselier Specific Uptake of Tumor Necrosis
Factor-$ \alpha $ Is Involved in Growth
Control of Trypanosoma brucei . . . . . 715
C. Michael DiPersio and
Kairbaan M. Hodivala-Dilke and
Rudolf Jaenisch and
Jordan A. Kreidberg and
Richard O. Hynes $ \alpha $3$ \beta $1 Integrin Is
Required for Normal Development of the
Epidermal Basement Membrane . . . . . . 729
Jian-Guo Geng and
Thomas J. Raub and
Carolyn A. Baker and
Geri A. Sawada and
Li Ma and
Åke P. Elhammer Expression of a P-selectin Ligand in
\bionameZona Pellucida of Porcine
Oocytes and P-selectin on Acrosomal
Membrane of Porcine Sperm Cells.
Potential Implications for Their
Involvement in Sperm--Egg Interactions 743
Rachael A. Clark and
Harold P. Erickson and
Timothy A. Springer Tenascin Supports Lymphocyte Rolling . . 755
W. Yu and
J. Kim and
L. Ossowski Reduction in Surface Urokinase Receptor
Forces Malignant Cells into a Protracted
State of Dormancy . . . . . . . . . . . 767
Paola Franco and
Ciro Iaccarino and
Ferdinando Chiaradonna and
Anna Brandazza and
Carlo Iavarone and
M. Rosaria Mastronicola and
M. Luisa Nolli and
M. Patrizia Stoppelli Phosphorylation of Human Pro--Urokinase
on Ser$^{138 \slash 303}$ Impairs Its
Receptor-dependent Ability to Promote
Myelomonocytic Adherence and Motility 779
J. Troy Littleton and
Manzoor A. Bhat and
Hugo J. Bellen Deciphering the Function of Neurexins at
Cellular Junctions . . . . . . . . . . . 793
M. Kathryn Iovine and
Susan R. Wente A Nuclear Export Signal in Kap95p Is
Required for Both Recycling the Import
Factor and Interaction with the
Nucleoporin GLFG Repeat Regions of
Nup116p and Nup100p . . . . . . . . . . 797
Nina Saris and
Heidi Holkeri and
Rachel A. Craven and
Colin J. Stirling and
Marja Makarow The Hsp70 Homologue Lhs1p Is Involved in
a Novel Function of the Yeast
Endoplasmic Reticulum, Refolding and
Stabilization of Heat-denatured Protein
Aggregates . . . . . . . . . . . . . . . 813
Fernando A. Agarraberes and
Stanley R. Terlecky and
J. Fred Dice An Intralysosomal hsp70 Is Required for
a Selective Pathway of Lysosomal Protein
Degradation . . . . . . . . . . . . . . 825
Fiona Simpson and
Andrew A. Peden and
Lina Christopoulou and
Margaret S. Robinson Characterization of the Adaptor-related
Protein Complex, AP-3 . . . . . . . . . 835
Michael Koval and
James E. Harley and
Elizabeth Hick and
Thomas H. Steinberg Connexin46 Is Retained as Monomers in a
trans -Golgi Compartment of Osteoblastic
Cells . . . . . . . . . . . . . . . . . 847
Feliciano Protasi and
Clara Franzini-Armstrong and
Bernhard E. Flucher Coordinated Incorporation of Skeletal
Muscle Dihydropyridine Receptors and
Ryanodine Receptors in Peripheral
Couplings of BC$_3$ H1 Cells . . . . . . 859
Ji Woong Han and
Jong Ho Park and
Misook Kim and
JooHun Lee mRNAs for Microtubule Proteins Are
Specifically Colocalized during the
Sequential Formation of Basal Body,
Flagella, and Cytoskeletal Microtubules
in the Differentiation of Naegleria
gruberi . . . . . . . . . . . . . . . . 871
Robert D. C. Saunders and
Maria do Carmo Avides and
Thomas Howard and
Cayetano Gonzalez and
David M. Glover The \bionameDrosophila Gene abnormal
spindle Encodes a Novel
Microtubule-associated Protein That
Associates with the Polar Regions of the
Mitotic Spindle . . . . . . . . . . . . 881
Hiroyuki Adachi and
Yasuhiro Takahashi and
Takeshi Hasebe and
Mikako Shirouzu and
Shigeyuki Yokoyama and
Kazuo Sutoh \bionameDictyostelium IQGAP-related
Protein Specifically Involved in the
Completion of Cytokinesis . . . . . . . 891
Hiroyuki Nishiyama and
Katsuhiko Itoh and
Yoshiyuki Kaneko and
Masamichi Kishishita and
Osamu Yoshida and
Jun Fujita A Glycine-rich RNA-binding Protein
Mediating Cold-inducible Suppression of
Mammalian Cell Growth . . . . . . . . . 899
Frank Rauch and
Bernhard Polzar and
Harald Stephan and
Silvia Zanotti and
Renate Paddenberg and
Hans Georg Mannherz Androgen Ablation Leads to an
Upregulation and Intranuclear
Accumulation of Deoxyribonuclease I in
Rat Prostate Epithelial Cells
Paralleling Their Apoptotic Elimination 909
Jill E. Hungerford and
James P. Hoeffler and
Chauncey W. Bowers and
Lisa M. Dahm and
Rocco Falchetto and
Jeffrey Shabanowitz and
Donald F. Hunt and
Charles D. Little Identification of a Novel Marker for
Primordial Smooth Muscle and Its
Differential Expression Pattern in
Contractile vs Noncontractile Cells . . 925
Robert A. Screaton and
Linda Z. Penn and
Clifford P. Stanners Carcinoembryonic Antigen, a Human Tumor
Marker, Cooperates with Myc and Bcl-2 in
Cellular Transformation . . . . . . . . 939
Kanaga T. Sabapathy and
Michael S. Pepper and
Friedemann Kiefer and
Uta Möhle-Steinlein and
Fabienne Tacchini-Cottier and
Ingrid Fetka and
Georg Breier and
Werner Risau and
Peter Carmeliet and
Roberto Montesano and
Erwin F. Wagner Polyoma Middle T-induced Vascular Tumor
Formation: The Role of the Plasminogen
Activator/Plasmin System . . . . . . . . 953
Sui Huang and
Thomas J. Deerinck and
Mark H. Ellisman and
David L. Spector The Dynamic Organization of the
Perinucleolar Compartment in the Cell
Nucleus . . . . . . . . . . . . . . . . 965
Margarida Gama-Carvalho and
Randy D. Krauss and
Lijian Chiang and
Juan Valcárcel and
Michael R. Green and
Maria Carmo-Fonseca Targeting of U2AF$^{65}$ to Sites of
Active Splicing in the Nucleus . . . . . 975
Ricardo Bastos and
Lluis Ribas de Pouplana and
Mark Enarson and
Khaldon Bodoor and
Brian Burke Nup84, A Novel Nucleoporin That Is
Associated With CAN/Nup214 on the
Cytoplasmic Face of the Nuclear Pore
Complex . . . . . . . . . . . . . . . . 989
Bettina Lenz-Böhme and
Jasmine Wismar and
Silke Fuchs and
Rita Reifegerste and
Erich Buchner and
Heinrich Betz and
Bertram Schmitt Insertional Mutation of the
\bionameDrosophila Nuclear Lamin Dm$_0$
Gene Results in Defective Nuclear
Envelopes, Clustering of Nuclear Pore
Complexes, and Accumulation of Annulate
Lamellae . . . . . . . . . . . . . . . . 1001
Inbok Paek and
Lelio Orci and
Mariella Ravazzola and
Hediye Erdjument-Bromage and
Mylene Amherdt and
Paul Tempst and
Thomas H. Söllner and
James E. Rothman ERS-24, a Mammalian v--SNARE Implicated
in Vesicle Traffic between the ER and
the Golgi . . . . . . . . . . . . . . . 1017
Marie-José J. E. Bijlmakers and
Misako Isobe-Nakamura and
Lindsay J. Ruddock and
Mark Marsh Intrinsic Signals in the Unique Domain
Target p56 $^{\rm lck}$ to the Plasma
Membrane Independently of CD4 . . . . . 1029
Toku Kanaseki and
Kazunori Kawasaki and
Masayuki Murata and
Yoko Ikeuchi and
Shun-ichi Ohnishi Structural Features of Membrane Fusion
between Influenza Virus and Liposome as
Revealed by Quick--Freezing Electron
Microscopy . . . . . . . . . . . . . . . 1041
Sergio Anastasi and
Silvia Giordano and
Olga Sthandier and
Giovanna Gambarotta and
Rossella Maione and
Paolo Comoglio and
Paolo Amati A Natural Hepatocyte Growth
Factor/Scatter Factor Autocrine Loop in
Myoblast Cells and the Effect of the
Constitutive Met Kinase Activation on
Myogenic Differentiation . . . . . . . . 1057
Anthony Koutoulis and
Gregory J. Pazour and
Curtis G. Wilkerson and
Kazuo Inaba and
Hong Sheng and
Saeko Takada and
George B. Witman The Chlamydomonas reinhardtii ODA3 Gene
Encodes a Protein of the Outer Dynein
Arm Docking Complex . . . . . . . . . . 1069
Ramila S. Patel-King and
Sharon E. Benashski and
Alistair Harrison and
Stephen M. King A Chlamydomonas Homologue of the
Putative Murine t Complex Distorter
Tctex-2 Is an Outer Arm Dynein Light
Chain . . . . . . . . . . . . . . . . . 1081
Peter J. Koch and
M. G. Mahoney and
Hiroyasu Ishikawa and
Leena Pulkkinen and
Jouni Uitto and
Leonard Shultz and
George F. Murphy and
Diana Whitaker-Menezes and
John R. Stanley Targeted Disruption of the
\bionamePemphigus Vulgaris Antigen
(Desmoglein 3) Gene in Mice Causes Loss
of Keratinocyte Cell Adhesion with a
Phenotype Similar to \bionamePemphigus
Vulgaris . . . . . . . . . . . . . . . . 1091
Jolanda van Hengel and
Lionel Gohon and
Erik Bruyneel and
Stefan Vermeulen and
Maria Cornelissen and
Marc Mareel and
Frans van Roy Protein Kinase C Activation Upregulates
Intercellular Adhesion of $ \alpha
$-Catenin--negative Human Colon Cancer
Cell Variants via Induction of
Desmosomes . . . . . . . . . . . . . . . 1103
David M. Farschon and
Clément Couture and
Tomas Mustelin and
Donald D. Newmeyer Temporal Phases in Apoptosis Defined by
the Actions of Src Homology 2 Domains,
Ceramide, Bcl-2, Interleukin-1$ \beta $
Converting Enzyme Family Proteases, and
a Dense Membrane Fraction . . . . . . . 1117
Andrzej Ptasznik and
Gillian M. Beattie and
Martin I. Mally and
Vincenzo Cirulli and
Ana Lopez and
Alberto Hayek Phosphatidylinositol 3-Kinase Is a
Negative Regulator of Cellular
Differentiation . . . . . . . . . . . . 1127
Johannes M. Weiss and
Jonathan Sleeman and
Andreas C. Renkl and
Henning Dittmar and
Christian C. Termeer and
Sabine Taxis and
Norma Howells and
Martin Hofmann and
Gabriele Köhler and
Erwin Schöpf and
Helmut Ponta and
Peter Herrlich and
Jan C. Simon An Essential Role for CD44 Variant
Isoforms in Epidermal Langerhans Cell
and Blood Dendritic Cell Function . . . 1137
Thorsten Kirsch and
Hyun-Duck Nah and
Irving M. Shapiro and
Maurizio Pacifici Regulated Production of
Mineralization-competent Matrix Vesicles
in Hypertrophic Chondrocytes . . . . . . 1149
Nancy R. Gough and
Douglas M. Fambrough Different Steady State Subcellular
Distributions of the Three Splice
Variants of Lysosome-associated Membrane
Protein LAMP-2 Are Determined Largely by
the COOH-terminal Amino Acid Residue . . 1161
Patricia L. Graham and
Jeffrey J. Johnson and
Shaoru Wang and
Marion H. Sibley and
Malini C. Gupta and
James M. Kramer Type IV Collagen Is Detectable in Most,
but Not All, Basement Membranes of
\bionameCaenorhabditis elegans and
Assembles on Tissues That Do Not Express
It . . . . . . . . . . . . . . . . . . . 1171
Malini C. Gupta and
Patricia L. Graham and
James M. Kramer Characterization of $ \alpha $1(IV)
Collagen Mutations in
\bionameCaenorhabditis elegans and the
Effects of $ \alpha $1 and $ \alpha
$2(IV) Mutations on Type IV Collagen
Distribution . . . . . . . . . . . . . . 1185
Li Yang and
Tinglu Guan and
Larry Gerace Integral Membrane Proteins of the
Nuclear Envelope Are Dispersed
throughout the Endoplasmic Reticulum
during Mitosis . . . . . . . . . . . . . 1199
David T. Shima and
Kasturi Haldar and
Rainer Pepperkok and
Rose Watson and
Graham Warren Partitioning of the Golgi Apparatus
during Mitosis in Living HeLa Cells . . 1211
Caroline Whitehouse and
Joy Burchell and
Stephen Gschmeissner and
Inka Brockhausen and
Kenneth O. Lloyd and
Joyce Taylor-Papadimitriou A Transfected Sialyltransferase That Is
Elevated in Breast Cancer and Localizes
to the medial/trans -Golgi Apparatus
Inhibits the Development of
core-$2$--based O--Glycans . . . . . . . 1229
Jan W. Slot and
Gabriella Garruti and
Sally Martin and
Viola Oorschot and
George Posthuma and
Edward W. Kraegen and
Ross Laybutt and
Gaétan Thibault and
David E. James Glucose Transporter (GLUT-4) Is Targeted
to Secretory Granules in Rat Atrial
Cardiomyocytes . . . . . . . . . . . . . 1243
Greg Odorizzi and
Ian S. Trowbridge Structural Requirements for Basolateral
Sorting of the Human Transferrin
Receptor in the Biosynthetic and
Endocytic Pathways of Madin--Darby
Canine Kidney Cells . . . . . . . . . . 1255
Gary A. Eitzen and
Rachel K. Szilard and
Richard A. Rachubinski Enlarged Peroxisomes Are Present in
Oleic Acid--grown Yarrowia lipolytica
Overexpressing the PEX16 Gene Encoding
an Intraperoxisomal Peripheral Membrane
Peroxin . . . . . . . . . . . . . . . . 1265
Jens Lübeck and
Lisa Heins and
Jürgen Soll A Nuclear-coded Chloroplastic Inner
Envelope Membrane Protein Uses a Soluble
Sorting Intermediate upon Import into
the Organelle . . . . . . . . . . . . . 1279
Tama Hasson and
Peter G. Gillespie and
Jesus A. Garcia and
Richard B. MacDonald and
Yi-dong Zhao and
Ann G. Yee and
Mark S. Mooseker and
David P. Corey Unconventional Myosins in Inner--Ear
Sensory Epithelia . . . . . . . . . . . 1287
Chikako Kitayama and
Asako Sugimoto and
Masayuki Yamamoto Type II Myosin Heavy Chain Encoded by
the myo2 Gene Composes the Contractile
Ring during Cytokinesis in
\bionameSchizosaccharomyces pombe . . . 1309
Sharyn A. Endow and
Donald J. Komma Spindle Dynamics during Meiosis in
\bionameDrosophila Oocytes . . . . . . . 1321
Lynne D. Berry and
Kathleen L. Gould Fission Yeast dim1$^+$ Encodes a
Functionally Conserved Polypeptide
Essential for Mitosis . . . . . . . . . 1337
Margaret Husta Butler and
Carol David and
Gian-Carlo Ochoa and
Zachary Freyberg and
Laurie Daniell and
Detlev Grabs and
Ottavio Cremona and
Pietro De Camilli Amphiphysin II (SH3P9; BIN1), a Member
of the Amphiphysin/Rvs Family, Is
Concentrated in the Cortical Cytomatrix
of Axon Initial Segments and Nodes of
Ranvier in Brain and around T Tubules in
Skeletal Muscle . . . . . . . . . . . . 1355
Stefan Ruepp and
André Furger and
Ursula Kurath and
Christina Kunz Renggli and
Andrew Hemphill and
Reto Brun and
Isabel Roditi Survival of Trypanosoma brucei in the
Tsetse Fly Is Enhanced by the Expression
of Specific Forms of Procyclin . . . . . 1369
Hél\`ene Marquis and
Howard Goldfine and
Daniel A. Portnoy Proteolytic Pathways of Activation and
Degradation of a Bacterial Phospholipase
C during Intracellular Infection by
\bionameListeria monocytogenes . . . . . 1381
Akira Sakakibara and
Mikio Furuse and
Mitinori Saitou and
Yuhko Ando-Akatsuka and
Shoichiro Tsukita Possible Involvement of Phosphorylation
of Occludin in Tight Junction Formation 1393
Pierre Savagner and
Kenneth M. Yamada and
Jean Paul Thiery The Zinc--Finger Protein Slug Causes
Desmosome Dissociation, an Initial and
Necessary Step for Growth
Factor--induced Epithelial--Mesenchymal
Transition . . . . . . . . . . . . . . . 1403
Vania M. M. Braga and
Laura M. Machesky and
Alan Hall and
Neil A. Hotchin The Small GTPases Rho and Rac Are
Required for the Establishment of
Cadherin-dependent Cell--Cell Contacts 1421
Hirokazu Kashiwagi and
Martin A. Schwartz and
Martin Eigenthaler and
K. A. Davis and
Mark H. Ginsberg and
Sanford J. Shattil Affinity Modulation of Platelet Integrin
$ \alpha_{\rm IIb} \beta_3 $ by $
\beta_3 $-Endonexin, a Selective Binding
Partner of the $ \beta_3 $ Integrin
Cytoplasmic Tail . . . . . . . . . . . . 1433
Brian K. Pilcher and
Jo Ann Dumin and
Barry D. Sudbeck and
Stephen M. Krane and
Howard G. Welgus and
William C. Parks The Activity of Collagenase-1 Is
Required for Keratinocyte Migration on a
Type I Collagen Matrix . . . . . . . . . 1445
James R. Abney and
Bryan Cutler and
Misty L. Fillbach and
Daniel Axelrod and
Bethe A. Scalettar Chromatin Dynamics in Interphase Nuclei
and Its Implications for Nuclear
Structure . . . . . . . . . . . . . . . 1459
Kevin J. Roberg and
Neil Rowley and
Chris A. Kaiser Physiological Regulation of Membrane
Protein Sorting Late in the Secretory
Pathway of \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 1469
Ann K. Corsi and
Randy Schekman The Lumenal Domain of Sec63p Stimulates
the ATPase Activity of BiP and Mediates
BiP Recruitment to the Translocon in
\bionameSaccharomyces cerevisiae . . . . 1483
Christiane Walch-Solimena and
Ruth N. Collins and
Peter J. Novick Sec2p Mediates Nucleotide Exchange on
Sec4p and Is Involved in Polarized
Delivery of Post-Golgi Vesicles . . . . 1495
Gabriele Fischer von Mollard and
Steven F. Nothwehr and
Tom H. Stevens The Yeast v--SNARE Vti1p Mediates Two
Vesicle Transport Pathways through
Interactions with the t--SNAREs Sed5p
and Pep12p . . . . . . . . . . . . . . . 1511
Jianwei Liu and
Thomas E. Hughes and
William C. Sessa The First 35 Amino Acids and Fatty
Acylation Sites Determine the Molecular
Targeting of Endothelial Nitric Oxide
Synthase into the Golgi Region of Cells:
a Green Fluorescent Protein Study . . . 1525
Nedra F. Wilson and
Mary J. Foglesong and
William J. Snell The Chlamydomonas Mating Type Plus
Fertilization Tubule, a Prototypic Cell
Fusion Organelle: Isolation,
Characterization, and In Vitro Adhesion
to Mating Type Minus Gametes . . . . . . 1537
Anne-Marie Bashour and
Aaron T. Fullerton and
Matthew J. Hart and
George S. Bloom IQGAP1, a Rac- and Cdc42-binding
Protein, Directly Binds and Cross-links
Microfilaments . . . . . . . . . . . . . 1555
Bruce F. McEwen and
Amy B. Heagle and
Grisel O. Cassels and
Karolyn F. Buttle and
Conly L. Rieder Kinetochore Fiber Maturation in PtK$_1$
Cells and Its Implications for the
Mechanisms of Chromosome Congression and
Anaphase Onset . . . . . . . . . . . . . 1567
Valter D. Longo and
Lisa M. Ellerby and
Dale E. Bredesen and
Joan S. Valentine and
Edith B. Gralla Human Bcl-2 Reverses Survival Defects in
Yeast Lacking Superoxide Dismutase and
Delays Death of Wild--Type Yeast . . . . 1581
Rytis Prekeris and
David M. Terrian Brain Myosin V Is a Synaptic
Vesicle-associated Motor Protein:
Evidence for a Ca$^2 + $-dependent
Interaction with the
Synaptobrevin--Synaptophysin Complex . . 1589
Martijn F. B. G. Gebbink and
Onno Kranenburg and
Mieke Poland and
Francis P. G. van Horck and
Brahim Houssa and
Wouter H. Moolenaar Identification of a Novel, Putative
Rho-specific GDP/GTP Exchange Factor and
a RhoA-binding Protein: Control of
Neuronal Morphology . . . . . . . . . . 1603
Yosuke Takei and
Satoru Kondo and
Akihiro Harada and
Satomi Inomata and
Tetsuo Noda and
Nobutaka Hirokawa Delayed Development of Nervous System in
Mice Homozygous for Disrupted
Microtubule-associated Protein 1B
(MAP1B) Gene . . . . . . . . . . . . . . 1615
Veronique Vandevoorde and
Guy Haegeman and
Walter Fiers Induced Expression of Trimerized
Intracellular Domains of the Human Tumor
Necrosis Factor (TNF) p55 Receptor
Elicits TNF Effects . . . . . . . . . . 1627
Russell D. J. Huby and
Makio Iwashima and
Arthur Weiss and
Steven C. Ley ZAP-70 Protein Tyrosine Kinase Is
Constitutively Targeted to the T Cell
Cortex Independently of its SH2 Domains 1639
Anne L. Pollack and
Angela I. M. Barth and
Yoram Altschuler and
W. James Nelson and
Keith E. Mostov Dynamics of $ \beta $-Catenin
Interactions with APC Protein Regulate
Epithelial Tubulogenesis . . . . . . . . 1651
Frédérique Monier-Gavelle and
Jean-Loup Duband Cross Talk between Adhesion Molecules:
Control of N-cadherin Activity by
Intracellular Signals Elicited by $
\beta $1 and $ \beta $3 Integrins in
Migrating Neural Crest Cells . . . . . . 1663
Sergei I. Bannykh and
William E. Balch Membrane Dynamics at the Endoplasmic
Reticulum-Golgi Interface . . . . . . . 1
Alexander M. Ishov and
Richard M. Stenberg and
Gerd G. Maul Human Cytomegalovirus Immediate Early
Interaction with Host Nuclear
Structures: Definition of an Immediate
Transcript Environment . . . . . . . . . 5
Robert A. Arkowitz and
Nick Lowe A Small Conserved Domain in the Yeast
Spa2p Is Necessary and Sufficient for
Its Polarized Localization . . . . . . . 17
Sidney V. Scott and
Misuzu Baba and
Yoshinori Ohsumi and
Daniel J. Klionsky Aminopeptidase I Is Targeted to the
Vacuole by a Nonclassical Vesicular
Mechanism . . . . . . . . . . . . . . . 37
Anna M. Castle and
Amy Y. Huang and
J. David Castle Passive Sorting in Maturing Granules of
AtT-20 Cells: The Entry and Exit of
Salivary Amylase and Proline-rich
Protein . . . . . . . . . . . . . . . . 45
Noriko Takahashi and
Takashi Kadowaki and
Yoshio Yazaki and
Yasushi Miyashita and
Haruo Kasai Multiple Exocytotic Pathways in
Pancreatic $ \beta $ Cells . . . . . . . 55
Dirk Görlich and
Marylena Dabrowski and
F. Ralf Bischoff and
Ulrike Kutay and
Peer Bork and
Enno Hartmann and
Siegfried Prehn and
Elisa Izaurralde A Novel Class of RanGTP Binding Proteins 65
Matthew F. Peters and
Marvin E. Adams and
Stanley C. Froehner Differential Association of Syntrophin
Pairs with the Dystrophin Complex . . . 81
Terry Lechler and
Rong Li In Vitro Reconstitution of Cortical
Actin Assembly Sites in Budding Yeast 95
P. T. Tran and
R. A. Walker and
E. D. Salmon A Metastable Intermediate State of
Microtubule Dynamic Instability That
Differs Significantly between Plus and
Minus Ends . . . . . . . . . . . . . . . 105
Roger Altman and
Douglas Kellogg Control of Mitotic Events by Nap1 and
the Gin4 Kinase . . . . . . . . . . . . 119
Olivier Seksek and
Joachim Biwersi and
A. S. Verkman Translational Diffusion of
Macromolecule-sized Solutes in Cytoplasm
and Nucleus . . . . . . . . . . . . . . 131
Yueqiao Huang and
John Jellies and
Kristen M. Johansen and
Jòrgen Johansen Differential Glycosylation of Tractin
and LeechCAM, Two Novel Ig Superfamily
Members, Regulates Neurite Extension and
Fascicle Formation . . . . . . . . . . . 143
James P. O'Malley and
Charlotte T. Moore and
Miriam M. Salpeter Stabilization of Acetylcholine Receptors
by Exogenous ATP and Its Reversal by
cAMP and Calcium . . . . . . . . . . . . 159
Craig M. Coopersmith and
Chitra Chandrasekaran and
M. Shane McNevin and
Jeffrey I. Gordon Bi-transgenic Mice Reveal that
K-ras$^{\rm Val12}$ Augments a
p53-independent Apoptosis When Small
Intestinal Villus Enterocytes Reenter
the Cell Cycle . . . . . . . . . . . . . 167
Masahiko Itoh and
Akira Nagafuchi and
Seiji Moroi and
Shoichiro Tsukita Involvement of ZO-1 in Cadherin-based
Cell Adhesion through Its Direct Binding
to $ \alpha $ Catenin and Actin
Filaments . . . . . . . . . . . . . . . 181
Nikolai A. Chitaev and
Sergey M. Troyanovsky Direct Ca$^{2+}$-dependent Heterophilic
Interaction between Desmosomal
Cadherins, Desmoglein and Desmocollin,
Contributes to Cell--Cell Adhesion . . . 193
Jong-Sun Kang and
Min Gao and
Jessica L. Feinleib and
Philip D. Cotter and
Sarah N. Guadagno and
Robert S. Krauss CDO: an Oncogene-, Serum-, and
Anchorage-regulated Member of the
Ig/Fibronectin Type III Repeat Family 203
Javier F. Cáceres and
Tom Misteli and
Gavin R. Screaton and
David L. Spector and
Adrian R. Krainer Role of the Modular Domains of SR
Proteins in Subnuclear Localization and
Alternative Splicing Specificity . . . . 225
Christian R. Eckmann and
Michael F. Jantsch Xlrbpa, a Double-stranded RNA-binding
Protein Associated with Ribosomes and
Heterogeneous Nuclear RNPs . . . . . . . 239
Leslie S. Kean and
Althea M. Grant and
Cesar Angeletti and
Yannick Mahé and
Karl Kuchler and
Robert S. Fuller and
J. Wylie Nichols Plasma Membrane Translocation of
Fluorescent-labeled
Phosphatidylethanolamine Is Controlled
by Transcription Regulators, PDR1 and
PDR3 . . . . . . . . . . . . . . . . . . 255
Jes Dietrich and
Jesper Kastrup and
Bodil L. Nielsen and
Niels Òdum and
Carsten Geisler Regulation and Function of the CD3$
\gamma $ DxxxLL Motif: a Binding Site
for Adaptor Protein-1 and Adaptor
Protein-2 in Vitro . . . . . . . . . . . 271
Elva Díaz and
Frauke Schimmöller and
Suzanne R. Pfeffer A Novel Rab9 Effector Required for
Endosome--to--TGN Transport . . . . . . 283
Anne Müsch and
David Cohen and
Enrique Rodriguez-Boulan Myosin II Is Involved in the Production
of Constitutive Transport Vesicles from
the TGN . . . . . . . . . . . . . . . . 291
Mirjam M. P. Zegers and
Dick Hoekstra Sphingolipid Transport to the Apical
Plasma Membrane Domain in Human Hepatoma
Cells Is Controlled by PKC and PKA
Activity: a Correlation with Cell
Polarity in HepG2 Cells . . . . . . . . 307
Harry F. G. Heijnen and
Viola Oorschot and
Jan J. Sixma and
Jan W. Slot and
David E. James Thrombin Stimulates Glucose Transport in
Human Platelets via the Translocation of
the Glucose Transporter GLUT-3 from $
\alpha $-Granules to the Cell Surface 323
Carol A. Charlton and
William A. Mohler and
Glenn L. Radice and
Richard O. Hynes and
Helen M. Blau Fusion Competence of Myoblasts Rendered
Genetically Null for N--Cadherin in
Culture . . . . . . . . . . . . . . . . 331
Achim Paululat and
Anette Goubeaud and
Christine Damm and
Stefan Knirr and
Susanne Burchard and
Renate Renkawitz-Pohl The Mesodermal Expression of rolling
stone (rost) Is Essential for Myoblast
Fusion in \bionameDrosophila and Encodes
a Potential Transmembrane Protein . . . 337
Jens Niewöhner and
Igor Weber and
Markus Maniak and
Annette Müller-Taubenberger and
Günther Gerisch Talin-Null Cells of
\bionameDictyostelium Are Strongly
Defective in Adhesion to Particle and
Substrate Surfaces and Slightly Impaired
in Cytokinesis . . . . . . . . . . . . . 349
Sally H. Zigmond and
Michael Joyce and
Jane Borleis and
Gary M. Bokoch and
Peter N. Devreotes Regulation of Actin Polymerization in
Cell-free Systems by GTP$ \gamma $S and
Cdc42 . . . . . . . . . . . . . . . . . 363
Matthew D. Welch and
Angela H. DePace and
Suzie Verma and
Akihiro Iwamatsu and
Timothy J. Mitchison The Human Arp2/3 Complex Is Composed of
Evolutionarily Conserved Subunits and Is
Localized to Cellular Regions of Dynamic
Actin Filament Assembly . . . . . . . . 375
Sally P. Wheatley and
Edward H. Hinchcliffe and
Michael Glotzer and
Anthony A. Hyman and
Greenfield Sluder and
Yu-li Wang CDK1 Inactivation Regulates Anaphase
Spindle Dynamics and Cytokinesis In Vivo 385
Luke Alphey and
Louise Parker and
Gillian Hawcroft and
Yiquan Guo and
Kim Kaiser and
Gareth Morgan KLP38B: a Mitotic Kinesin-related
Protein That Binds PP1 . . . . . . . . . 395
Donna L. Senger and
Robert B. Campenot Rapid Retrograde Tyrosine
Phosphorylation of trkA and Other
Proteins in Rat Sympathetic Neurons in
Compartmented Cultures . . . . . . . . . 411
Tiziana Crepaldi and
Alexis Gautreau and
Paolo M. Comoglio and
Daniel Louvard and
Monique Arpin Ezrin Is an Effector of Hepatocyte
Growth Factor--mediated Migration and
Morphogenesis in Epithelial Cells . . . 423
Thomas Sternsdorf and
Kirsten Jensen and
Dirk Züchner and
Hans Will Cellular Localization, Expression, and
Structure of the Nuclear Dot Protein 52 435
Mariangela Mancini and
Benjamin O. Anderson and
Elizabeth Caldwell and
Monireh Sedghinasab and
Philip B. Paty and
David M. Hockenbery Mitochondrial Proliferation and
Paradoxical Membrane Depolarization
during Terminal Differentiation and
Apoptosis in a Human Colon Carcinoma
Cell Line . . . . . . . . . . . . . . . 449
Martín I. García-Castro and
Robert Anderson and
Janet Heasman and
Christopher Wylie Interactions between Germ Cells and
Extracellular Matrix Glycoproteins
during Migration and Gonad Assembly in
the Mouse Embryo . . . . . . . . . . . . 471
Alexander A. Mironov and
Peggy Weidman and
Alberto Luini Variations on the Intracellular
Transport Theme: Maturing Cisternae and
Trafficking Tubules . . . . . . . . . . 481
Harold A. Fisk and
Michael P. Yaffe Mutational Analysis of Mdm1p Function in
Nuclear and Mitochondrial Inheritance 485
Ye-Guang Chen and
Anirban Siddhanta and
Cary D. Austin and
Scott M. Hammond and
Tsung-Chang Sung and
Michael A. Frohman and
Andrew J. Morris and
Dennis Shields Phospholipase D Stimulates Release of
Nascent Secretory Vesicles from the
trans -Golgi Network . . . . . . . . . . 495
Victor Faúndez and
Jim-Tong Horng and
Regis B. Kelly ADP Ribosylation Factor 1 Is Required
for Synaptic Vesicle Budding in PC12
Cells . . . . . . . . . . . . . . . . . 505
Tamara Darsow and
Stephanie E. Rieder and
Scott D. Emr A Multispecificity Syntaxin Homologue,
Vam3p, Essential for Autophagic and
Biosynthetic Protein Transport to the
Vacuole . . . . . . . . . . . . . . . . 517
Robert C. Piper and
Nia J. Bryant and
Tom H. Stevens The Membrane Protein Alkaline
Phosphatase Is Delivered to the Vacuole
by a Route That Is Distinct from the
VPS-dependent Pathway . . . . . . . . . 531
Mathilde Waser and
Nasrin Mesaeli and
Charlotte Spencer and
Marek Michalak Regulation of Calreticulin Gene
Expression by Calcium . . . . . . . . . 547
Michel O. Steinmetz and
Kenneth N. Goldie and
Ueli Aebi A Correlative Analysis of Actin Filament
Assembly, Structure, and Dynamics . . . 559
Dorothy J. Roof and
Annmarie Hayes and
Michael Adamian and
Athar H. Chishti and
Tiansen Li Molecular Characterization of abLIM, a
Novel Actin-binding and Double Zinc
Finger Protein . . . . . . . . . . . . . 575
Mary Ruth S. Erickson and
Brian J. Galletta and
Susan M. Abmayr Drosophila myoblast city Encodes a
Conserved Protein That Is Essential for
Myoblast Fusion, Dorsal Closure, and
Cytoskeletal Organization . . . . . . . 589
Richard I. Tuxworth and
Janet L. Cheetham and
Laura M. Machesky and
George B. Spiegelmann and
Gerald Weeks and
Robert H. Insall \bionameDictyostelium RasG Is Required
for Normal Motility and Cytokinesis, But
Not Growth . . . . . . . . . . . . . . . 605
Rebecca Heald and
Régis Tournebize and
Anja Habermann and
Eric Karsenti and
Anthony Hyman Spindle Assembly in \bionameXenopus Egg
Extracts: Respective Roles of
Centrosomes and Microtubule
Self--Organization . . . . . . . . . . . 615
Janet L. Carminati and
Tim Stearns Microtubules Orient the Mitotic Spindle
in Yeast through Dynein-dependent
Interactions with the Cell Cortex . . . 629
Ganesan Gopalan and
Clarence S. M. Chan and
Peter J. Donovan A Novel Mammalian, Mitotic
Spindle--associated Kinase Is Related to
Yeast and Fly Chromosome Segregation
Regulators . . . . . . . . . . . . . . . 643
Gerardo Morfini and
Santiago Quiroga and
Alberto Rosa and
Kenneth Kosik and
Alfredo Cáceres Suppression of KIF2 in PC12 Cells Alters
the Distribution of a Growth Cone
Nonsynaptic Membrane Receptor and
Inhibits Neurite Extension . . . . . . . 657
Abraham S. C. Chyung and
Barry D. Greenberg and
David G. Cook and
Robert W. Doms and
Virginia M.-Y. Lee Novel $ \beta $-Secretase Cleavage of $
\beta $-Amyloid Precursor Protein in the
Endoplasmic Reticulum/Intermediate
Compartment of NT2N Cells . . . . . . . 671
Babette Aicher and
Markus M. Lerch and
Thomas Müller and
James Schilling and
Axel Ullrich Cellular Redistribution of Protein
Tyrosine Phosphatases LAR and PTP$
\sigma $ by Inducible Proteolytic
Processing . . . . . . . . . . . . . . . 681
Paola Chiozzi and
Juana M. Sanz and
Davide Ferrari and
Simonetta Falzoni and
Arrigo Aleotti and
Gary N. Buell and
Ginetta Collo and
Francesco Di Virgilio Spontaneous Cell Fusion in Macrophage
Cultures Expressing High Levels of the
P2Z/P2X$_7$ Receptor . . . . . . . . . . 697
David W. Dawson and
S. Frieda A. Pearce and
Ruiqin Zhong and
Roy L. Silverstein and
William A. Frazier and
Noël P. Bouck CD36 Mediates the In Vitro Inhibitory
Effects of Thrombospondin-1 on
Endothelial Cells . . . . . . . . . . . 707
Patricia Rousselle and
Douglas R. Keene and
Florence Ruggiero and
Marie-France Champliaud and
Michel van der Rest and
Robert E. Burgeson Laminin 5 Binds the NC-1 Domain of Type
VII Collagen . . . . . . . . . . . . . . 719
Wen-jie Luo and
Amy Chang Novel Genes Involved in Endosomal
Traffic in Yeast Revealed by Suppression
of a Targeting-defective Plasma Membrane
ATPase Mutant . . . . . . . . . . . . . 731
Peter J. Dempsey and
Katherine S. Meise and
Yoshino Yoshitake and
Katsuzo Nishikawa and
Robert J. Coffey Apical Enrichment of Human EGF Precursor
in Madin--Darby Canine Kidney Cells
Involves Preferential Basolateral
Ectodomain Cleavage Sensitive to a
Metalloprotease Inhibitor . . . . . . . 747
Timothy L. Cover and
Phyllis I. Hanson and
John E. Heuser Acid-induced Dissociation of VacA, the
Helicobacter pylori Vacuolating
Cytotoxin, Reveals Its Pattern of
Assembly . . . . . . . . . . . . . . . . 759
Amy McGough and
Brian Pope and
Wah Chiu and
Alan Weeds Cofilin Changes the Twist of F--Actin:
Implications for Actin Filament Dynamics
and Cellular Function . . . . . . . . . 771
Gregory M. Guild and
Patricia S. Connelly and
Michael K. Shaw and
Lewis G. Tilney Actin Filament Cables in
\bionameDrosophila Nurse Cells Are
Composed of Modules That Slide Passively
Past One Another during Dumping . . . . 783
Douglas N. Robinson and
Lynn Cooley Drosophila Kelch Is an Oligomeric Ring
Canal Actin Organizer . . . . . . . . . 799
Hui-qiao Sun and
Keng-mean Lin and
Helen L. Yin Gelsolin Modulates Phospholipase C
Activity In Vivo through Phospholipid
Binding . . . . . . . . . . . . . . . . 811
Guoling Tian and
Sally A. Lewis and
Becket Feierbach and
Timothy Stearns and
Heidi Rommelaere and
Christophe Ampe and
Nicholas J. Cowan Tubulin Subunits Exist in an Activated
Conformational State Generated and
Maintained by Protein Cofactors . . . . 821
David J. Sharp and
Wenqian Yu and
Lotfi Ferhat and
Ryoko Kuriyama and
David C. Rueger and
Peter W. Baas Identification of a
Microtubule-associated Motor Protein
Essential for Dendritic Differentiation 833
Susan Spencer and
Donald Dowbenko and
Jill Cheng and
Wenlu Li and
Jennifer Brush and
Suzan Utzig and
Viesturs Simanis and
Laurence A. Lasky PSTPIP: a Tyrosine Phosphorylated
Cleavage Furrow--associated Protein that
Is a Substrate for a PEST Tyrosine
Phosphatase . . . . . . . . . . . . . . 845
Robert W. Burgess and
David L. Deitcher and
Thomas L. Schwarz The Synaptic Protein Syntaxin1 Is
Required for Cellularization of
\bionameDrosophila Embryos . . . . . . . 861
Bénédicte Dehouck and
Laurence Fenart and
Marie-Pierre Dehouck and
Annick Pierce and
Gérard Torpier and
Roméo Cecchelli A New Function for the LDL Receptor:
Transcytosis of LDL across the
Blood--Brain Barrier . . . . . . . . . . 877
Yan-hua Chen and
Christa Merzdorf and
David L. Paul and
Daniel A. Goodenough COOH Terminus of Occludin Is Required
for Tight Junction Barrier Function in
Early \bionameXenopus Embryos . . . . . 891
Gaël McGill and
Akiko Shimamura and
Richard C. Bates and
Robert E. Savage and
David E. Fisher Loss of Matrix Adhesion Triggers Rapid
Transformation--Selective Apoptosis in
Fibroblasts . . . . . . . . . . . . . . 901
Laura M. Machesky and
Alan Hall Role of Actin Polymerization and
Adhesion to Extracellular Matrix in Rac-
and Rho-induced Cytoskeletal
Reorganization . . . . . . . . . . . . . 913
Deborah J. G. Mackay and
Fred Esch and
Heinz Furthmayr and
Alan Hall Rho- and Rac-dependent Assembly of Focal
Adhesion Complexes and Actin Filaments
in Permeabilized Fibroblasts: an
Essential Role for Ezrin/Radixin/Moesin
Proteins . . . . . . . . . . . . . . . . 927
Hiromi Sesaki and
Estella F. S. Wong and
Chi-Hung Siu The Cell Adhesion Molecule DdCAD-1 in
\bionameDictyostelium Is Targeted to the
Cell Surface by a Nonclassical Transport
Pathway Involving Contractile Vacuoles 939
Andreas Merdes and
Don W. Cleveland Pathways of Spindle Pole Formation:
Different Mechanisms; Conserved
Components . . . . . . . . . . . . . . . 953
Tim Stearns Motoring to the Finish: Kinesin and
Dynein Work Together to Orient the Yeast
Mitotic Spindle . . . . . . . . . . . . 957
Jennifer Philips and
Ira Herskowitz Osmotic Balance Regulates Cell Fusion
during Mating in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 961
José R. Castón and
Benes L. Trus and
Frank P. Booy and
Reed B. Wickner and
Joseph S. Wall and
Alasdair C. Steven Structure of L--A Virus: a Specialized
Compartment for the Transcription and
Replication of Double-stranded RNA . . . 975
Paul E. Ross and
George R. Ehring and
Michael D. Cahalan Dynamics of ATP-induced Calcium
Signaling in Single Mouse Thymocytes . . 987
Guo-Qiang Bi and
Robert L. Morris and
Guochun Liao and
Janet M. Alderton and
Jonathan M. Scholey and
Richard A. Steinhardt Kinesin- and Myosin-driven Steps of
Vesicle Recruitment for
Ca$^{2+}$-regulated Exocytosis . . . . . 999
Robert L. Morris and
Jonathan M. Scholey Heterotrimeric Kinesin--II Is Required
for the Assembly of Motile 9+2 Ciliary
Axonemes on Sea Urchin Embryos . . . . . 1009
Todd M. DeZwaan and
Eric Ellingson and
David Pellman and
David M. Roof Kinesin-related KIP3 of
\bionameSaccharomyces cerevisiae Is
Required for a Distinct Step in Nuclear
Migration . . . . . . . . . . . . . . . 1023
Frank R. Cottingham and
M. Andrew Hoyt Mitotic Spindle Positioning in
\bionameSaccharomyces cerevisiae Is
Accomplished by Antagonistically Acting
Microtubule Motor Proteins . . . . . . . 1041
Tirso Gaglio and
Mary A. Dionne and
Duane A. Compton Mitotic Spindle Poles are Organized by
Structural and Motor Proteins in
Addition to Centrosomes . . . . . . . . 1055
Harald Felgner and
Rainer Frank and
Jacek Biernat and
Eva-Maria Mandelkow and
Eckhard Mandelkow and
Beat Ludin and
Andrew Matus and
Manfred Schliwa Domains of Neuronal
Microtubule-associated Proteins and
Flexural Rigidity of Microtubules . . . 1067
Kevin Ainger and
Daniela Avossa and
Amy S. Diana and
Christopher Barry and
Elisa Barbarese and
John H. Carson Transport and Localization Elements in
Myelin Basic Protein mRNA . . . . . . . 1077
Thomas R. Cimato and
Murray J. Ettinger and
Xianbo Zhou and
John M. Aletta Nerve Growth Factor--specific Regulation
of Protein Methylation during Neuronal
Differentiation of PC12 Cells . . . . . 1089
Hitoshi Nishijima and
Hideo Nishitani and
Takashi Seki and
Takeharu Nishimoto A Dual-Specificity Phosphatase Cdc25B Is
an Unstable Protein and Triggers
p34$^{\rm cdc2}$ /Cyclin B Activation in
Hamster BHK21 Cells Arrested with
Hydroxyurea . . . . . . . . . . . . . . 1105
William C. Aird and
Jay M. Edelberg and
Hartmut Weiler-Guettler and
William W. Simmons and
Thomas W. Smith and
Robert D. Rosenberg Vascular Bed--specific Expression of an
Endothelial Cell Gene Is Programmed by
the Tissue Microenvironment . . . . . . 1117
H. Makarenkova and
D. L. Becker and
C. Tickle and
A. E. Warner Fibroblast Growth Factor 4 Directs Gap
Junction Expression in the Mesenchyme of
the Vertebrate Limb Bud . . . . . . . . 1125
David A. Nix and
Mary C. Beckerle Nuclear--Cytoplasmic Shuttling of the
Focal Contact Protein, Zyxin: a
Potential Mechanism for Communication
between Sites of Cell Adhesion and the
Nucleus . . . . . . . . . . . . . . . . 1139
David D. Chang and
Carol Wong and
Healy Smith and
Jenny Liu ICAP-1, a Novel $ \beta_1 $ Integrin
Cytoplasmic Domain-associated Protein,
Binds to a Conserved and Functionally
Important NPXY Sequence Motif of $
\beta_1 $ Integrin . . . . . . . . . . . 1149
Lisbet Camper and
Dick Heinegård and
Evy Lundgren-Åkerlund Integrin $ \alpha $2$ \beta $1 Is a
Receptor for the Cartilage Matrix
Protein Chondroadherin . . . . . . . . . 1159
Ronen Alon and
Shuqi Chen and
Kamal D. Puri and
Erik B. Finger and
Timothy A. Springer The Kinetics of L-selectin Tethers and
the Mechanics of Selectin-mediated
Rolling . . . . . . . . . . . . . . . . 1169
Mikiko C. Siomi and
Paul S. Eder and
Naoyuki Kataoka and
Lili Wan and
Qing Liu and
Gideon Dreyfuss Transportin-mediated Nuclear Import of
Heterogeneous Nuclear RNP Proteins . . . 1181
Jan Ellenberg and
Eric D. Siggia and
Jorge E. Moreira and
Carolyn L. Smith and
John F. Presley and
Howard J. Worman and
Jennifer Lippincott-Schwartz Nuclear Membrane Dynamics and Reassembly
in Living Cells: Targeting of an Inner
Nuclear Membrane Protein in Interphase
and Mitosis . . . . . . . . . . . . . . 1193
Hél\`ene Boeuf and
Charlotte Hauss and
Fabienne De Graeve and
Nathalie Baran and
Claude Kedinger Leukemia Inhibitory Factor-dependent
Transcriptional Activation in Embryonic
Stem Cells . . . . . . . . . . . . . . . 1207
Huiling He and
Minh Lam and
Thomas S. McCormick and
Clark W. Distelhorst Maintenance of Calcium Homeostasis in
the Endoplasmic Reticulum by Bcl-2 . . . 1219
Bjòrn Holst and
Christine Tachibana and
Jakob R. Winther Active Site Mutations in Yeast Protein
Disulfide Isomerase Cause Dithiothreitol
Sensitivity and a Reduced Rate of
Protein Folding in the Endoplasmic
Reticulum . . . . . . . . . . . . . . . 1229
Michele A. West and
Nicholas A. Bright and
Margaret S. Robinson The Role of ADP-ribosylation Factor and
Phospholipase D in Adaptor Recruitment 1239
Roney O. Laine and
William Zeile and
Fan Kang and
Daniel L. Purich and
Frederick S. Southwick Vinculin Proteolysis Unmasks an ActA
Homolog for Actin-based Shigella
Motility . . . . . . . . . . . . . . . . 1255
Suranganie Dharmawardhane and
Luraynne C. Sanders and
Stuart S. Martin and
R. Hugh Daniels and
Gary M. Bokoch Localization of p21-Activated Kinase 1
(PAK1) to Pinocytic Vesicles and
Cortical Actin Structures in Stimulated
Cells . . . . . . . . . . . . . . . . . 1265
Mei Lu and
Walter Witke and
David J. Kwiatkowski and
Kenneth S. Kosik Delayed Retraction of Filopodia in
Gelsolin Null Mice . . . . . . . . . . . 1279
Daniel A. Starr and
Byron C. Williams and
Zexiao Li and
Bijan Etemad-Moghadam and
R. Kelly Dawe and
Michael L. Goldberg Conservation of the
Centromere/Kinetochore Protein ZW10 . . 1289
David J. Carroll and
Chodavarapu S. Ramarao and
Lisa M. Mehlmann and
Serge Roche and
Mark Terasaki and
Laurinda A. Jaffe Calcium Release at Fertilization in
Starfish Eggs Is Mediated by
Phospholipase C$ \gamma $ . . . . . . . 1303
Toshinobu Tokumoto and
Masakane Yamashita and
Mika Tokumoto and
Yoshinao Katsu and
Ryo Horiguchi and
Hiroko Kajiura and
Yoshitaka Nagahama Initiation of Cyclin B Degradation by
the 26S Proteasome upon Egg Activation 1313
Ann Redfield and
Marvin T. Nieman and
Karen A. Knudsen Cadherins Promote Skeletal Muscle
Differentiation in Three-dimensional
Cultures . . . . . . . . . . . . . . . . 1323
Christof Zitt and
Alexander G. Obukhov and
Carsten Strübing and
Andrea Zobel and
Frank Kalkbrenner and
Andreas Lückhoff and
Günter Schultz Expression of TRPC3 in Chinese Hamster
Ovary Cells Results in Calcium-activated
Cation Currents Not Related to Store
Depletion . . . . . . . . . . . . . . . 1333
Pekka Kallunki and
Gerald M. Edelman and
Frederick S. Jones Tissue-specific Expression of the L1
Cell Adhesion Molecule Is Modulated by
the Neural Restrictive Silencer Element 1343
Song Tang and
Ying Jing Shen and
Maria Elena DeBellard and
Gitali Mukhopadhyay and
James L. Salzer and
Paul R. Crocker and
Marie T. Filbin Myelin-associated Glycoprotein Interacts
with Neurons via a Sialic Acid Binding
Site at ARG118 and a Distinct Neurite
Inhibition Site . . . . . . . . . . . . 1355
Fen-Biao Gao and
Martin Raff Cell Size Control and a Cell-intrinsic
Maturation Program in Proliferating
Oligodendrocyte Precursor Cells . . . . 1367
Carlos Caulín and
Guy S. Salvesen and
Robert G. Oshima Caspase Cleavage of Keratin 18 and
Reorganization of Intermediate Filaments
during Epithelial Cell Apoptosis . . . . 1379
Kelly M. McNagny and
Inger Pettersson and
Fabio Rossi and
Ingo Flamme and
Andrej Shevchenko and
Matthias Mann and
Thomas Graf Thrombomucin, a Novel Cell Surface
Protein that Defines Thrombocytes and
Multipotent Hematopoietic Progenitors 1395
Juan M. Serrador and
José L. Alonso-Lebrero and
Miguel A. del Pozo and
Heinz Furthmayr and
Reinhard Schwartz-Albiez and
Javier Calvo and
Francisco Lozano and
Francisco Sánchez-Madrid Moesin Interacts with the Cytoplasmic
Region of Intercellular Adhesion
Molecule-3 and Is Redistributed to the
Uropod of T Lymphocytes during Cell
Polarization . . . . . . . . . . . . . . 1409
Julie Famiglietti and
Jing Sun and
Horace M. DeLisser and
Steven M. Albelda Tyrosine Residue in Exon 14 of the
Cytoplasmic Domain of Platelet
Endothelial Cell Adhesion Molecule-1
(PECAM-1/CD31) Regulates Ligand Binding
Specificity . . . . . . . . . . . . . . 1425
Joanna C. Porter and
Nancy Hogg Integrin Cross Talk: Activation of
Lymphocyte Function-associated Antigen-1
on Human T Cells Alters $ \alpha $4$
\beta $1- and $ \alpha $5$ \beta
$1-mediated Function . . . . . . . . . . 1437
Bahram Houchmandzadeh and
John F. Marko and
Didier Chatenay and
Albert Libchaber Elasticity and Structure of Eukaryote
Chromosomes Studied by Micromanipulation
and Micropipette Aspiration . . . . . . 1
Tin Tin Su and
Patrick H. O'Farrell Chromosome Association of Minichromosome
Maintenance Proteins in
\bionameDrosophila Mitotic Cycles . . . 13
Jason H. Brickner and
Robert S. Fuller SOI1 Encodes a Novel, Conserved Protein
That Promotes TGN--Endosomal Cycling of
Kex2p and Other Membrane Proteins by
Modulating the Function of Two TGN
Localization Signals . . . . . . . . . . 23
Michelangelo Foti and
Aram Mangasarian and
Vincent Piguet and
Daniel P. Lew and
Karl-Heinz Krause and
Didier Trono and
Jean-Louis Carpentier Nef-mediated Clathrin-coated Pit
Formation . . . . . . . . . . . . . . . 37
Harish Radhakrishna and
Julie G. Donaldson ADP-Ribosylation Factor 6 Regulates a
Novel Plasma Membrane Recycling Pathway 49
Mark Terasaki and
Katsuya Miyake and
Paul L. McNeil Large Plasma Membrane Disruptions Are
Rapidly Resealed by Ca$^{2+}$-dependent
Vesicle--Vesicle Fusion Events . . . . . 63
Douglas J. DeMarini and
Alison E. M. Adams and
Hanna Fares and
Claudio De Virgilio and
Giorgio Valle and
John S. Chuang and
John R. Pringle A Septin-based Hierarchy of Proteins
Required for Localized Deposition of
Chitin in the \bionameSaccharomyces
cerevisiae Cell Wall . . . . . . . . . . 75
Stephanie Ruf and
Hans Kössel and
Ralph Bock Targeted Inactivation of a Tobacco
Intron--containing Open Reading Frame
Reveals a Novel Chloroplast-encoded
Photosystem I--related Gene . . . . . . 95
Helena Webb and
Nicola Carnall and
Luc Vanhamme and
Sylvie Rolin and
Jakke Van Den Abbeele and
Sue Welburn and
Etienne Pays and
Mark Carrington The GPI--Phospholipase C of Trypanosoma
brucei Is Nonessential But Influences
Parasitemia in Mice . . . . . . . . . . 103
Dietmar Zechner and
Donna J. Thuerauf and
Deanna S. Hanford and
Patrick M. McDonough and
Christopher C. Glembotski A Role for the p38 Mitogen-activated
Protein Kinase Pathway in Myocardial
Cell Growth, Sarcomeric Organization,
and Cardiac-specific Gene Expression . . 115
Zhenlin Li and
Mathias Mericskay and
Onnik Agbulut and
Gillian Butler-Browne and
Lena Carlsson and
Lars-Eric Thornell and
Charles Babinet and
Denise Paulin Desmin Is Essential for the Tensile
Strength and Integrity of Myofibrils but
Not for Myogenic Commitment,
Differentiation, and Fusion of Skeletal
Muscle . . . . . . . . . . . . . . . . . 129
Shao Jun Du and
Stephen H. Devoto and
Monte Westerfield and
Randall T. Moon Positive and Negative Regulation of
Muscle Cell Identity by Members of the
hedgehog and TGF-$ \beta $ Gene Families 145
Pascal Pomi\`es and
Heather A. Louis and
Mary C. Beckerle CRP1, a LIM Domain Protein Implicated in
Muscle Differentiation, Interacts with $
\alpha $-Actinin . . . . . . . . . . . . 157
David Reczek and
Mark Berryman and
Anthony Bretscher Identification of EBP50: a
PDZ-containing Phosphoprotein that
Associates with Members of the
Ezrin--Radixin--Moesin Family . . . . . 169
J. E. Sugiyama and
D. J. Glass and
G. D. Yancopoulos and
Z. W. Hall Laminin-induced Acetylcholine Receptor
Clustering: an Alternative Pathway . . . 181
Peter Mundel and
Hans W. Heid and
Thomas M. Mundel and
Meike Krüger and
Jochen Reiser and
Wilhelm Kriz Synaptopodin: an Actin-associated
Protein in Telencephalic Dendrites and
Renal Podocytes . . . . . . . . . . . . 193
Timothy M. Miller and
Krista L. Moulder and
C. Michael Knudson and
Douglas J. Creedon and
Mohanish Deshmukh and
Stanley J. Korsmeyer and
Eugene M. Johnson Bax Deletion Further Orders the Cell
Death Pathway in Cerebellar Granule
Cells and Suggests a Caspase-independent
Pathway to Cell Death . . . . . . . . . 205
Marek Litwin and
Katherine Clark and
Leanne Noack and
Jill Furze and
Michael Berndt and
Steven Albelda and
Mathew Vadas and
Jennifer Gamble Novel Cytokine-independent Induction of
Endothelial Adhesion Molecules Regulated
by Platelet/Endothelial Cell Adhesion
Molecule (CD31) . . . . . . . . . . . . 219
Jeffrey R. Miller and
Randall T. Moon Analysis of the Signaling Activities of
Localization Mutants of $ \beta
$-Catenin during Axis Specification in
\bionameXenopus . . . . . . . . . . . . 229
J. J. Emeis and
Y. van den Eijnden-Schrauwen and
C. M. van den Hoogen and
W. de Priester and
A. Westmuckett and
F. Lupu An Endothelial Storage Granule for
Tissue--Type Plasminogen Activator . . . 245
Nancy Boudreau and
Catherine Andrews and
Anabella Srebrow and
Ali Ravanpay and
David A. Cheresh Induction of the Angiogenic Phenotype by
Hox D3 . . . . . . . . . . . . . . . . . 257
Wilhelm Bloch and
Erik Forsberg and
Sylvia Lentini and
Cord Brakebusch and
Karl Martin and
Hans W. Krell and
Ulrich H. Weidle and
Klaus Addicks and
Reinhard Fässler $ \beta $1 Integrin Is Essential for
Teratoma Growth and Angiogenesis . . . . 265
Peter Lloyd Jones and
Julie Crack and
Marlene Rabinovitch Regulation of Tenascin-C, a Vascular
Smooth Muscle Cell Survival Factor that
Interacts with the $ \alpha_v \beta_3 $
Integrin to Promote Epidermal Growth
Factor Receptor Phosphorylation and
Growth . . . . . . . . . . . . . . . . . 279
Ri-ichiroh Manabe and
Naoko Oh-e and
Toshinaga Maeda and
Tomohiko Fukuda and
Kiyotoshi Sekiguchi Modulation of Cell-adhesive Activity of
Fibronectin by the Alternatively Spliced
EDA Segment . . . . . . . . . . . . . . 295
Peter M. Lansdorp Lessons from Mice without Telomerase . . 309
Irene Boche and
Ellen Fanning Nucleocytoplasmic Recycling of the
Nuclear Localization Signal Receptor $
\alpha $ Subunit In Vivo Is Dependent on
a Nuclear Export Signal, Energy, and
RCC1 . . . . . . . . . . . . . . . . . . 313
Florence W. H. Ng and
Mai Nguyen and
Tony Kwan and
Philip E. Branton and
Donald W. Nicholson and
James A. Cromlish and
Gordon C. Shore p28 Bap31, a Bcl-2/Bcl--X$_L$- and
Procaspase-8--associated Protein in the
Endoplasmic Reticulum . . . . . . . . . 327
Steven M. Jones and
Kathryn E. Howell Phosphatidylinositol 3--Kinase Is
Required for the Formation of
Constitutive Transport Vesicles from the
TGN . . . . . . . . . . . . . . . . . . 339
Scott C. Milligan and
James G. Alb and
Raya B. Elagina and
Vytas A. Bankaitis and
David R. Hyde The Phosphatidylinositol Transfer
Protein Domain of \bionameDrosophila
Retinal Degeneration B Protein Is
Essential for Photoreceptor Cell
Survival and Recovery from Light
Stimulation . . . . . . . . . . . . . . 351
Zhan Xiao and
Ning Zhang and
Douglas B. Murphy and
Peter N. Devreotes Dynamic Distribution of Chemoattractant
Receptors in Living Cells During
Chemotaxis and Persistent Stimulation 365
Volker Straub and
Jill A. Rafael and
Jeffrey S. Chamberlain and
Kevin P. Campbell Animal Models for Muscular Dystrophy
Show Different Patterns of Sarcolemmal
Disruption . . . . . . . . . . . . . . . 375
Dorit Hanein and
Paul Matsudaira and
David J. DeRosier Evidence for a Conformational Change in
Actin Induced by Fimbrin (N375) Binding 387
Tatyana M. Svitkina and
Alexander B. Verkhovsky and
Kyle M. McQuade and
Gary G. Borisy Analysis of the Actin--Myosin II System
in Fish Epidermal Keratocytes: Mechanism
of Cell Body Translocation . . . . . . . 397
Clare M. Waterman-Storer and
E. D. Salmon Actomyosin-based Retrograde Flow of
Microtubules in the Lamella of Migrating
Epithelial Cells Influences Microtubule
Dynamic Instability and Turnover and Is
Associated with Microtubule Breakage and
Treadmilling . . . . . . . . . . . . . . 417
Xuebiao Yao and
Karen L. Anderson and
Don W. Cleveland The Microtubule-dependent Motor
Centromere--associated Protein E
(CENP--E) Is an Integral Component of
Kinetochore Corona Fibers That Link
Centromeres to Spindle Microtubules . . 435
Yuka Nagata and
Yoshinao Muro and
Kazuo Todokoro Thrombopoietin-induced Polyploidization
of Bone Marrow Megakaryocytes Is Due to
a Unique Regulatory Mechanism in Late
Mitosis . . . . . . . . . . . . . . . . 449
Carol A. Bascom-Slack and
Dean S. Dawson The Yeast Motor Protein, Kar3p, Is
Essential for Meiosis I . . . . . . . . 459
Janis K. Burkhardt and
Christophe J. Echeverri and
Tommy Nilsson and
Richard B. Vallee Overexpression of the Dynamitin (p50)
Subunit of the Dynactin Complex Disrupts
Dynein-dependent Maintenance of Membrane
Organelle Distribution . . . . . . . . . 469
Susan Janicki and
Mervyn J. Monteiro Increased Apoptosis Arising from
Increased Expression of the Alzheimer's
Disease--associated Presenilin-2
Mutation (N141I) . . . . . . . . . . . . 485
Niklas R. Jòrgensen and
Steven T. Geist and
Roberto Civitelli and
Thomas H. Steinberg ATP- and Gap Junction-dependent
Intercellular Calcium Signaling in
Osteoblastic Cells . . . . . . . . . . . 497
Houhui Xia and
Sara T. Winokur and
Wen-Lin Kuo and
Michael R. Altherr and
David S. Bredt Actinin-associated LIM Protein:
Identification of a Domain Interaction
between PDZ and Spectrin-like Repeat
Motifs . . . . . . . . . . . . . . . . . 507
Kenji Mandai and
Hiroyuki Nakanishi and
Ayako Satoh and
Hiroshi Obaishi and
Manabu Wada and
Hideo Nishioka and
Masahiko Itoh and
Akira Mizoguchi and
Takeo Aoki and
Toyoshi Fujimoto and
Yoichi Matsuda and
Shoichiro Tsukita and
Yoshimi Takai Afadin: a Novel Actin Filament--binding
Protein with One PDZ Domain Localized at
Cadherin-based Cell--to--Cell Adherens
Junction . . . . . . . . . . . . . . . . 517
Wen-cheng Xiong and
J. Thomas Parsons Induction of Apoptosis after Expression
of PYK2, a Tyrosine Kinase Structurally
Related to Focal Adhesion Kinase . . . . 529
Rosa Serra and
Mahlon Johnson and
Ellen H. Filvaroff and
James LaBorde and
Daniel M. Sheehan and
Rik Derynck and
Harold L. Moses Expression of a Truncated,
Kinase--Defective TGF-$ \beta $ Type II
Receptor in Mouse Skeletal Tissue
Promotes Terminal Chondrocyte
Differentiation and Osteoarthritis . . . 541
Lucia Schuger and
Amy P. N. Skubitz and
Jun Zhang and
Lydia Sorokin and
Li He Laminin $ \alpha $1 Chain Synthesis in
the Mouse Developing Lung: Requirement
for Epithelial--Mesenchymal Contact and
Possible Role in Bronchial Smooth muscle
Development . . . . . . . . . . . . . . 553
M. Abi Abitorabi and
Russell K. Pachynski and
Ronald E. Ferrando and
Mark Tidswell and
David J. Erle Presentation of Integrins on Leukocyte
Microvilli: a Role for the Extracellular
Domain in Determining Membrane
Localization . . . . . . . . . . . . . . 563
Martin Alexander Schwartz Integrins, Oncogenes, and Anchorage
Independence . . . . . . . . . . . . . . 575
M. Cristina Cardoso and
Cuthbert Joseph and
Hans-Peter Rahn and
Regina Reusch and
Bernardo Nadal-Ginard and
Heinrich Leonhardt Mapping and Use of a Sequence that
Targets DNA Ligase I to Sites of DNA
Replication In Vivo . . . . . . . . . . 579
Sankar Addya and
Hindupur K. Anandatheerthavarada and
Gopa Biswas and
Shripad V. Bhagwat and
Jayati Mullick and
Narayan G. Avadhani Targeting of NH$_2$-terminal-processed
Microsomal Protein to Mitochondria: A
Novel Pathway for the Biogenesis of
Hepatic Mitochondrial P450MT2 . . . . . 589
Mayte Montero and
Javier Alvarez and
Wilhelm J. J. Scheenen and
Rosario Rizzuto and
Jacopo Meldolesi and
Tullio Pozzan Ca$^{2+}$ Homeostasis in the Endoplasmic
Reticulum: Coexistence of High and Low
[Ca$^{2+}$] Subcompartments in Intact
HeLa Cells . . . . . . . . . . . . . . . 601
Daniel N. Hebert and
Jian-Xin Zhang and
Wei Chen and
Brigitte Foellmer and
Ari Helenius The Number and Location of Glycans on
Influenza Hemagglutinin Determine
Folding and Association with Calnexin
and Calreticulin . . . . . . . . . . . . 613
Laurent Muller and
Xiaorong Zhu and
Iris Lindberg Mechanism of the Facilitation of PC2
Maturation by 7B2: Involvement in ProPC2
Transport and Activation but Not Folding 625
Monique J. Kleijmeer and
Stanislaw Morkowski and
Janice M. Griffith and
Alexander Y. Rudensky and
Hans J. Geuze Major Histocompatibility Complex Class
II Compartments in Human and Mouse B
Lymphoblasts Represent Conventional
Endocytic Compartments . . . . . . . . . 639
Natalie Signoret and
Joanne Oldridge and
Annegret Pelchen-Matthews and
Per J. Klasse and
Thanh Tran and
Lawrence F. Brass and
Mette M. Rosenkilde and
Thue W. Schwartz and
William Holmes and
Walt Dallas and
Michael A. Luther and
Timothy N. C. Wells and
James A. Hoxie and
Mark Marsh Phorbol Esters and SDF-1 Induce Rapid
Endocytosis and Down Modulation of the
Chemokine Receptor CXCR4 . . . . . . . . 651
Diane M. Ward and
Jonathan D. Leslie and
Jerry Kaplan Homotypic Lysosome Fusion in
Macrophages: Analysis Using an In Vitro
Assay . . . . . . . . . . . . . . . . . 665
S. A. Burgess and
M. L. Walker and
H. D. White and
J. Trinick Flexibility within Myosin Heads Revealed
by Negative Stain and Single--Particle
Analysis . . . . . . . . . . . . . . . . 675
James D. Jontes and
Ronald A. Milligan Brush Border Myosin--I Structure and
ADP-dependent Conformational Changes
Revealed by Cryoelectron Microscopy and
Image Analysis . . . . . . . . . . . . . 683
Holger Schmitz and
Mary C. Reedy and
Michael K. Reedy and
Richard T. Tregear and
Kenneth A. Taylor Tomographic Three-dimensional
Reconstruction of Insect Flight Muscle
Partially Relaxed by AMPPNP and Ethylene
Glycol . . . . . . . . . . . . . . . . . 695
G. D. Sterne and
G. R. Coulton and
R. A. Brown and
C. J. Green and
G. Terenghi Neurotrophin-$3$--enhanced Nerve
Regeneration Selectively Improves
Recovery of Muscle Fibers Expressing
Myosin Heavy Chains 2b . . . . . . . . . 709
Jens D. Beinhauer and
Iain M. Hagan and
Johannes H. Hegemann and
Ursula Fleig Mal3, the Fission Yeast Homologue of the
Human APC-interacting Protein EB-1 Is
Required for Microtubule Integrity and
the Maintenance of Cell Form . . . . . . 717
Frank Madeo and
Eleonore Fröhlich and
Kai-Uwe Fröhlich A Yeast Mutant Showing Diagnostic
Markers of Early and Late Apoptosis . . 729
Hideki Chiba and
John Clifford and
Daniel Metzger and
Pierre Chambon Specific and Redundant Functions of
Retinoid X Receptor/Retinoic Acid
Receptor Heterodimers in
Differentiation, Proliferation, and
Apoptosis of F9 Embryonal Carcinoma
Cells . . . . . . . . . . . . . . . . . 735
Takahisa Kondo and
Kosei Takeuchi and
Yoshinori Doi and
Shigenobu Yonemura and
Shigekazu Nagata and
Shoichiro Tsukita and
Sachiko Tsukita ERM (Ezrin/Radixin/Moesin)-based
Molecular Mechanism of Microvillar
Breakdown at an Early Stage of Apoptosis 749
Claudio Brancolini and
Dean Lazarevic and
Joe Rodriguez and
Claudio Schneider Dismantling Cell--Cell Contacts during
Apoptosis Is Coupled to a
Caspase-dependent Proteolytic Cleavage
of $ \beta $-Catenin . . . . . . . . . . 759
Andrew P. Kowalczyk and
Elayne A. Bornslaeger and
Jeffrey E. Borgwardt and
Helena L. Palka and
Avninder S. Dhaliwal and
Connie M. Corcoran and
Mitchell F. Denning and
Kathleen J. Green The Amino-terminal Domain of Desmoplakin
Binds to Plakoglobin and Clusters
Desmosomal Cadherin--Plakoglobin
Complexes . . . . . . . . . . . . . . . 773
Takaharu Yamamoto and
Naozumi Harada and
Kyoko Kano and
Shin-ichiro Taya and
Eli Canaani and
Yoshiharu Matsuura and
Akira Mizoguchi and
Chizuka Ide and
Kozo Kaibuchi The Ras Target AF-6 Interacts with ZO-1
and Serves as a Peripheral Component of
Tight Junctions in Epithelial Cells . . 785
Frank N. van Leeuwen and
Hendrie E. T. Kain and
Rob A. van der Kammen and
Frits Michiels and
Onno W. Kranenburg and
John G. Collard The Guanine Nucleotide Exchange Factor
Tiam1 Affects Neuronal Morphology;
Opposing Roles for the Small GTPases Rac
and Rho . . . . . . . . . . . . . . . . 797
Karen L. Philpott and
Mary Jane McCarthy and
Anke Klippel and
Lee L. Rubin Activated Phosphatidylinositol 3-Kinase
and Akt Kinase Promote Survival of
Superior Cervical Neurons . . . . . . . 809
Michaela Wilsch-Bräuninger and
Heinz Schwarz and
Christiane Nüsslein-Volhard A Sponge-like Structure Involved in the
Association and Transport of Maternal
Products during \bionameDrosophila
Oogenesis . . . . . . . . . . . . . . . 817
Hong-Guo Yu and
Evelyn N. Hiatt and
Annette Chan and
Mary Sweeney and
R. Kelly Dawe Neocentromere-mediated Chromosome
Movement in Maize . . . . . . . . . . . 831
Shingo Kose and
Naoko Imamoto and
Taro Tachibana and
Takuya Shimamoto and
Yoshihiro Yoneda Ran-unassisted Nuclear Migration of a
97-kD Component of Nuclear
Pore--targeting Complex . . . . . . . . 841
Yu Liang and
Monika Häring and
Peter J. Roughley and
Renée K. Margolis and
Richard U. Margolis Glypican and Biglycan in the Nuclei of
Neurons and Glioma Cells: Presence of
Functional Nuclear Localization Signals
and Dynamic Changes in Glypican During
the Cell Cycle . . . . . . . . . . . . . 851
Nathalie Dejucq and
Suzanne Chousterman and
Bernard Jégou The Testicular Antiviral Defense System:
Localization, Expression, and Regulation
of 2'5' Oligoadenylate Synthetase,
Double--Stranded RNA-activated Protein
Kinase, and Mx Proteins in the Rat
Seminiferous Tubule . . . . . . . . . . 865
Richard J. O. Barnard and
Alan Morgan and
Robert D. Burgoyne Stimulation of NSF ATPase Activity by $
\alpha $-SNAP Is Required for SNARE
Complex Disassembly and Exocytosis . . . 875
Corey Smith and
Erwin Neher Multiple Forms of Endocytosis In Bovine
Adrenal Chromaffin Cells . . . . . . . . 885
Jesus A. Gutierrez and
Jianming Yu and
Susan Rivera and
Marianne Wessling-Resnick Functional Expression Cloning and
Characterization of SFT, a Stimulator of
Fe Transport . . . . . . . . . . . . . . 895
Yongjian Liu and
Robert H. Edwards Differential Localization of Vesicular
Acetylcholine and Monoamine Transporters
in PC12 Cells but Not CHO Cells . . . . 907
Anne E. West and
Rachael L. Neve and
Kathleen M. Buckley Targeting of the Synaptic Vesicle
Protein Synaptobrevin in the Axon of
Cultured Hippocampal Neurons: Evidence
for Two Distinct Sorting Steps . . . . . 917
Charles Yeaman and
Annick H. Le Gall and
Anne N. Baldwin and
Laure Monlauzeur and
Andre Le Bivic and
Enrique Rodriguez-Boulan The O-glycosylated Stalk Domain Is
Required for Apical Sorting of
Neurotrophin Receptors in Polarized MDCK
Cells . . . . . . . . . . . . . . . . . 929
Wouter van't Hof and
Abha Malik and
S. Vijayakumar and
Jizeng Qiao and
Janet van Adelsberg and
Qais Al-Awqati The Effect of Apical and Basolateral
Lipids on the Function of the Band 3
Anion Exchange Protein . . . . . . . . . 941
Hiroyuki Nakanishi and
Hiroshi Obaishi and
Ayako Satoh and
Manabu Wada and
Kenji Mandai and
Keiko Satoh and
Hideo Nishioka and
Yoshiharu Matsuura and
Akira Mizoguchi and
Yoshimi Takai Neurabin: a Novel Neural
Tissue--specific Actin Filament--binding
Protein Involved in Neurite Formation 951
Hiroshi Sato and
Toshio Nagai and
Dhandapani Kuppuswamy and
Takahiro Narishige and
Masaaki Koide and
Donald R. Menick and
George Cooper Microtubule Stabilization in Pressure
Overload Cardiac Hypertrophy . . . . . . 963
Sòren S. L. Andersen and
Eric Karsenti XMAP310: a \bionameXenopus
Rescue-promoting Factor Localized to the
Mitotic Spindle . . . . . . . . . . . . 975
Sidney L. Shaw and
Elaine Yeh and
Paul Maddox and
E. D. Salmon and
Kerry Bloom Astral Microtubule Dynamics in Yeast: a
Microtubule-based Searching Mechanism
for Spindle Orientation and Nuclear
Migration into the Bud . . . . . . . . . 985
Manuela Vecchi and
Graham Carpenter Constitutive Proteolysis of the ErbB-4
Receptor Tyrosine Kinase by a Unique,
Sequential Mechanism . . . . . . . . . . 995
Fumiko Toyoshima and
Tetsuo Moriguchi and
Eisuke Nishida Fas Induces Cytoplasmic Apoptotic
Responses and Activation of the
MKK7-JNK/SAPK and MKK6-p38 Pathways
Independent of CPP32-like Proteases . . 1005
Asim Khwaja and
Julian Downward Lack of Correlation between Activation
of Jun--NH$_2$-terminal Kinase and
Induction of Apoptosis after Detachment
of Epithelial Cells . . . . . . . . . . 1017
Glenn L. Radice and
M. Celeste Ferreira-Cornwell and
Stephen D. Robinson and
Helen Rayburn and
Lewis A. Chodosh and
Masatoshi Takeichi and
Richard O. Hynes Precocious Mammary Gland Development in
P--Cadherin--deficient Mice . . . . . . 1025
Ravinder N. M. Sehgal and
Barry M. Gumbiner and
Louis F. Reichardt Antagonism of Cell Adhesion by an $
\alpha $-Catenin Mutant, and of the
Wnt-signaling Pathway by $ \alpha
$-Catenin in \bionameXenopus Embryos . . 1033
Kenji Takaishi and
Takuya Sasaki and
Hirokazu Kotani and
Hideo Nishioka and
Yoshimi Takai Regulation of Cell--Cell Adhesion by Rac
and Rho Small G Proteins in MDCK Cells 1047
Christopher T. Beh and
Valeria Brizzio and
Mark D. Rose KAR5 Encodes a Novel Pheromone-inducible
Protein Required for Homotypic Nuclear
Fusion . . . . . . . . . . . . . . . . . 1063
Li Yang and
Tinglu Guan and
Larry Gerace Lamin-binding Fragment of LAP2 Inhibits
Increase in Nuclear Volume during the
Cell Cycle and Progression into S Phase 1077
Kazutoyo Terada and
Masaki Kanazawa and
Bernd Bukau and
Masataka Mori The Human DnaJ Homologue dj2 Facilitates
Mitochondrial Protein Import and
Luciferase Refolding . . . . . . . . . . 1089
Charles Barlowe Coupled ER to Golgi Transport
Reconstituted with Purified Cytosolic
Proteins . . . . . . . . . . . . . . . . 1097
Alexander Mironov and
Antonino Colanzi and
Maria Giuseppina Silletta and
Giusy Fiucci and
Silvio Flati and
Aurora Fusella and
Roman Polishchuk and
Alexander Mironov and
Giuseppe Di Tullio and
Roberto Weigert and
Vivek Malhotra and
Daniela Corda and
Maria Antonietta De Matteis and
Alberto Luini Role of NAD$^+$ and ADP--Ribosylation in
the Maintenance of the Golgi Structure 1109
Manuel Rojo and
Rainer Pepperkok and
Gregory Emery and
Roland Kellner and
Espen Stang and
Robert G. Parton and
Jean Gruenberg Involvement of the Transmembrane Protein
p23 in Biosynthetic Protein Transport 1119
Noah Sciaky and
John Presley and
Carolyn Smith and
Kristien J. M. Zaal and
Nelson Cole and
Jorge E. Moreira and
Mark Terasaki and
Eric Siggia and
Jennifer Lippincott-Schwartz Golgi Tubule Traffic and the Effects of
Brefeldin A Visualized in Living Cells 1137
Tao Zhang and
Siew Heng Wong and
Bor Luen Tang and
Yue Xu and
Frank Peter and
V. Nathan Subramaniam and
Wanjin Hong The Mammalian Protein (rbet1) Homologous
to Yeast Bet1p Is Primarily Associated
with the Pre-Golgi Intermediate
Compartment and Is Involved in Vesicular
Transport from the Endoplasmic Reticulum
to the Golgi Apparatus . . . . . . . . . 1157
Karl R. Fath and
Gina M. Trimbur and
David R. Burgess Molecular Motors and a Spectrin Matrix
Associate with Golgi Membranes In Vitro 1169
Feng Gu and
Fernando Aniento and
Robert G. Parton and
Jean Gruenberg Functional Dissection of COP--I Subunits
in the Biogenesis of Multivesicular
Endosomes . . . . . . . . . . . . . . . 1183
N. Doane Chilcoat and
Aaron P. Turkewitz In Vivo Analysis of the Major
Exocytosis-sensitive Phosphoprotein in
\bionameTetrahymena . . . . . . . . . . 1197
Jennifer M. Green and
Alan D. Schreiber and
Eric J. Brown Role for a Glycan Phosphoinositol Anchor
in Fc$ \gamma $ Receptor Synergy . . . . 1209
Leslie J. R. Acakpo-Satchivi and
Winfried Edelmann and
Carol Sartorius and
Brian D. Lu and
Philip A. Wahr and
Simon C. Watkins and
Joseph M. Metzger and
Leslie Leinwand and
Raju Kucherlapati Growth and Muscle Defects in Mice
Lacking Adult Myosin Heavy Chain Genes 1219
Anja Baumeister and
Silvia Arber and
Pico Caroni Accumulation of Muscle Ankyrin Repeat
Protein Transcript Reveals Local
Activation of Primary Myotube
Endcompartments during Muscle
Morphogenesis . . . . . . . . . . . . . 1231
R. J. Eddy and
J. Han and
J. S. Condeelis Capping Protein Terminates but Does Not
Initiate Chemoattractant-induced Actin
Assembly in \bionameDictyostelium . . . 1243
Kersi N. Pestonjamasp and
Robert K. Pope and
Julia D. Wulfkuhle and
Elizabeth J. Luna Supervillin (p205): a Novel
Membrane-associated, F-Actin-binding
Protein in the Villin/Gelsolin
Superfamily . . . . . . . . . . . . . . 1255
Peijing Jeremy Wang and
Tim C. Huffaker Stu2p: a Microtubule-Binding Protein
that Is an Essential Component of the
Yeast Spindle Pole Body . . . . . . . . 1271
Keith G. Wolter and
Yi-Te Hsu and
Carolyn L. Smith and
Amotz Nechushtan and
Xu-Guang Xi and
Richard J. Youle Movement of Bax from the Cytosol to
Mitochondria during Apoptosis . . . . . 1281
Phyllis L. Faust and
Mary E. Hatten Targeted Deletion of the PEX2 Peroxisome
Assembly Gene in Mice Provides a Model
for Zellweger Syndrome, a Human Neuronal
Migration Disorder . . . . . . . . . . . 1293
Bin Zhang and
Pang-hsien Tu and
Farhad Abtahian and
John Q. Trojanowski and
Virginia M.-Y. Lee Neurofilaments and Orthograde Transport
Are Reduced in Ventral Root Axons of
Transgenic Mice that Express Human SOD1
with a G93A Mutation . . . . . . . . . . 1307
Yonghong Li and
Pamela Maher and
David Schubert Requirement for cGMP in Nerve Cell Death
Caused by Glutathione Depletion . . . . 1317
Daniela Salomon and
Paula A. Sacco and
Sujata Guha Roy and
Inbal Simcha and
Keith R. Johnson and
Margaret J. Wheelock and
Avri Ben-Ze'ev Regulation of $ \beta $-Catenin Levels
and Localization by Overexpression of
Plakoglobin and Inhibition of the
Ubiquitin--Proteasome System . . . . . . 1325
Sergey V. Litvinov and
Maarten Balzar and
Manon J. Winter and
Hellen A. M. Bakker and
Inge H. Briaire-de Bruijn and
Frans Prins and
Gert Jan Fleuren and
Sven O. Warnaar Epithelial Cell Adhesion Molecule
(Ep--CAM) Modulates Cell--Cell
Interactions Mediated by Classic
Cadherins . . . . . . . . . . . . . . . 1337
Ellen F. Foxman and
James J. Campbell and
Eugene C. Butcher Multistep Navigation and the
Combinatorial Control of Leukocyte
Chemotaxis . . . . . . . . . . . . . . . 1349
Isabel Molina and
Sigrid Baars and
Julie A. Brill and
Karen G. Hales and
Margaret T. Fuller and
Pedro Ripoll A Chromatin-associated Kinesin-related
Protein Required for Normal Mitotic
Chromosome Segregation in
\bionameDrosophila . . . . . . . . . . . 1361
B. T. Schaar and
G. K. T. Chan and
P. Maddox and
E. D. Salmon and
T. J. Yen CENP-E Function at Kinetochores Is
Essential for Chromosome Alignment . . . 1373
Christopher W. Espelin and
Kenneth B. Kaplan and
Peter K. Sorger Probing the Architecture of a Simple
Kinetochore Using DNA--Protein
Crosslinking . . . . . . . . . . . . . . 1383
Wim G. Annaert and
Bernd Becker and
Ute Kistner and
Michael Reth and
Reinhard Jahn Export of Cellubrevin from the
Endoplasmic Reticulum Is Controlled by
BAP31 . . . . . . . . . . . . . . . . . 1397
Michael Maceyka and
Carolyn E. Machamer Ceramide Accumulation Uncovers a Cycling
Pathway for the cis -Golgi Network
Marker, Infectious Bronchitis Virus M
Protein . . . . . . . . . . . . . . . . 1411
Hans R. Waterham and
Kimberly A. Russell and
Yne de Vries and
James M. Cregg Peroxisomal Targeting, Import, and
Assembly of Alcohol Oxidase in Pichia
pastoris . . . . . . . . . . . . . . . . 1419
Giorgio Ferrari and
Andrew M. Knight and
Colin Watts and
Jean Pieters Distinct Intracellular Compartments
Involved in Invariant Chain Degradation
and Antigenic Peptide Loading of Major
Histocompatibility Complex (MHC) Class
II Molecules . . . . . . . . . . . . . . 1433
Thomas P. Stauffer and
Tobias Meyer Compartmentalized IgE Receptor--mediated
Signal Transduction in Living Cells . . 1447
Lorraine D. Hernandez and
Reuben J. Peters and
Sue E. Delos and
John A. T. Young and
David A. Agard and
Judith M. White Activation of a Retroviral Membrane
Fusion Protein: Soluble Receptor-induced
Liposome Binding of the ALSV Envelope
Glycoprotein . . . . . . . . . . . . . . 1455
Norio Sakai and
Keiko Sasaki and
Natsu Ikegaki and
Yasuhito Shirai and
Yoshitaka Ono and
Naoaki Saito Direct Visualization of the
Translocation of the $ \gamma
$-Subspecies of Protein Kinase C in
Living Cells Using Fusion Proteins with
Green Fluorescent Protein . . . . . . . 1465
D. C. Ghislaine Mayer and
Leslie A. Leinwand Sarcomeric Gene Expression and
Contractility in Myofibroblasts . . . . 1477
Martina H. Lauber and
Irene Waizenegger and
Thomas Steinmann and
Heinz Schwarz and
Ulrike Mayer and
Inwhan Hwang and
Wolfgang Lukowitz and
Gerd Jürgens The Arabidopsis KNOLLE Protein Is a
Cytokinesis-specific Syntaxin . . . . . 1485
Steven Einheber and
George Zanazzi and
William Ching and
Steven Scherer and
Teresa A. Milner and
Elior Peles and
James L. Salzer The Axonal Membrane Protein Caspr, a
Homologue of Neurexin IV, Is a Component
of the Septate-like Paranodal Junctions
That Assemble during Myelination . . . . 1495
Bruce L. Patton and
Jeffrey H. Miner and
Arlene Y. Chiu and
Joshua R. Sanes Distribution and Function of Laminins in
the Neuromuscular System of Developing,
Adult, and Mutant Mice . . . . . . . . . 1507
Sòren Skov and
Pia Klausen and
Mogens H. Claesson Ligation of Major Histocompatability
Complex (MHC) Class I Molecules on Human
T Cells Induces Cell Death through PI-3
Kinase-induced c-Jun NH$_2$-terminal
Kinase Activity: A Novel Apoptotic
Pathway Distinct from Fas-induced
Apoptosis . . . . . . . . . . . . . . . 1523
Yuan Su and
Yufang Shi and
Melissa A. Stolow and
Yun-Bo Shi Thyroid Hormone Induces Apoptosis in
Primary Cell Cultures of Tadpole
Intestine: Cell Type Specificity and
Effects of Extracellular Matrix . . . . 1533
D. Holstead Jones and
Tyler C. Davies and
Gerald M. Kidder Embryonic Expression of the Putative $
\gamma $ Subunit of the Sodium Pump Is
Required for Acquisition of Fluid
Transport Capacity during Mouse
Blastocyst Development . . . . . . . . . 1545
Olivier Lorentz and
Isabelle Duluc and
Ad\`ele De Arcangelis and
Patricia Simon-Assmann and
Mich\`ele Kedinger and
Jean-Noël Freund Key Role of the Cdx2 Homeobox Gene in
Extracellular Matrix--mediated
Intestinal Cell Differentiation . . . . 1553
Brunhilde Felding-Habermann and
Steve Silletti and
Fang Mei and
Chi-Hung Siu and
Paul M. Yip and
Peter C. Brooks and
David A. Cheresh and
Timothy E. O'Toole and
Mark H. Ginsberg and
Anthony M. P. Montgomery A Single Immunoglobulin-like Domain of
the Human Neural Cell Adhesion Molecule
L1 Supports Adhesion by Multiple
Vascular and Platelet Integrins . . . . 1567
Alexey M. Belkin and
S. Francesco Retta and
Olga Y. Pletjushkina and
Fiorella Balzac and
Lorenzo Silengo and
Reinhard Fassler and
Victor E. Koteliansky and
Keith Burridge and
Guido Tarone Muscle $ \beta $1D Integrin Reinforces
the Cytoskeleton--Matrix Link:
Modulation of Integrin Adhesive Function
by Alternative Splicing . . . . . . . . 1583
João Ferreira and
Giovanni Paolella and
Carlos Ramos and
Angus I. Lamond Spatial Organization of Large-Scale
Chromatin Domains in the Nucleus: a
Magnified View of Single Chromosome
Territories . . . . . . . . . . . . . . 1597
Renée LeMaire-Adkins and
Kristi Radke and
Patricia A. Hunt Lack of Checkpoint Control at the
Metaphase/Anaphase Transition: a
Mechanism of Meiotic Nondisjunction in
Mammalian Females . . . . . . . . . . . 1611
Thomas Sternsdorf and
Kirsten Jensen and
Hans Will Evidence for Covalent Modification of
the Nuclear Dot-associated Proteins PML
and Sp100 by PIC1/SUMO-1 . . . . . . . . 1621
Davide Ferrari and
Sebastian Wesselborg and
Manuel K. A. Bauer and
Klaus Schulze-Osthoff Extracellular ATP Activates
Transcription Factor NF-$ \kappa $B
through the P2Z Purinoreceptor by
Selectively Targeting NF-$ \kappa $B p65
(RelA) . . . . . . . . . . . . . . . . . 1635
Lucy F. Pemberton and
Jonathan S. Rosenblum and
Günter Blobel A Distinct and Parallel Pathway for the
Nuclear Import of an mRNA-binding
Protein . . . . . . . . . . . . . . . . 1645
Jonathan S. Rosenblum and
Lucy F. Pemberton and
Günter Blobel A Nuclear Import Pathway for a Protein
Involved in tRNA Maturation . . . . . . 1655
Oliver Kerscher and
Jason Holder and
Maithreyan Srinivasan and
Roxanne S. Leung and
Robert E. Jensen The Tim54p--Tim22p Complex Mediates
Insertion of Proteins into the
Mitochondrial Inner Membrane . . . . . . 1663
Andrei Kouranov and
Danny J. Schnell Analysis of the Interactions of
Preproteins with the Import Machinery
over the Course of Protein Import into
Chloroplasts . . . . . . . . . . . . . . 1677
Misuzu Baba and
Masako Osumi and
Sidney V. Scott and
Daniel J. Klionsky and
Yoshinori Ohsumi Two Distinct Pathways for Targeting
Proteins from the Cytoplasm to the
Vacuole/Lysosome . . . . . . . . . . . . 1687
Christopher V. Nicchitta and
Tianli Zheng Regulation of the Ribosome--Membrane
Junction at Early Stages of Presecretory
Protein Translocation in the Mammalian
Endoplasmic Reticulum . . . . . . . . . 1697
Helmut Plattner and
Antonio R. Artalejo and
Erwin Neher Ultrastructural Organization of Bovine
Chromaffin Cell Cortex --- Analysis by
Cryofixation and Morphometry of Aspects
Pertinent to Exocytosis . . . . . . . . 1709
Gseping Liu and
Laurel Thomas and
Robin A. Warren and
Caroline A. Enns and
C. Casey Cunningham and
John H. Hartwig and
Gary Thomas Cytoskeletal Protein ABP-280 Directs the
Intracellular Trafficking of Furin and
Modulates Proprotein Processing in the
Endocytic Pathway . . . . . . . . . . . 1719
Nathan Wolins and
Herbert Bosshart and
Helmut Küster and
Juan S. Bonifacino Aggregation As a Determinant of Protein
Fate in Post-Golgi Compartments: Role of
the Luminal Domain of Furin in Lysosomal
Targeting . . . . . . . . . . . . . . . 1735
Elizabeth Daro and
David Sheff and
Marie Gomez and
Thomas Kreis and
Ira Mellman Inhibition of Endosome Function in CHO
Cells Bearing a Temperature-sensitive
Defect in the Coatomer (COPI) Component
$ \epsilon $-COP . . . . . . . . . . . . 1747
J. David Stepp and
Kristen Huang and
Sandra K. Lemmon The Yeast Adaptor Protein Complex, AP-3,
Is Essential for the Efficient Delivery
of Alkaline Phosphatase by the Alternate
Pathway to the Vacuole . . . . . . . . . 1761
Erik L. Snapp and
Scott M. Landfear Cytoskeletal Association Is Important
for Differential Targeting of Glucose
Transporter Isoforms in Leishmania . . . 1775
Xiaojun Guan and
Benjamin F. Cravatt and
George R. Ehring and
James E. Hall and
Dale L. Boger and
Richard A. Lerner and
Norton B. Gilula The Sleep-inducing Lipid Oleamide
Deconvolutes Gap Junction Communication
and Calcium Wave Transmission in Glial
Cells . . . . . . . . . . . . . . . . . 1785
Ralph Neujahr and
Christina Heizer and
Richard Albrecht and
Maria Ecke and
Jean-Marc Schwartz and
Igor Weber and
Günther Gerisch Three-dimensional Patterns and
Redistribution of Myosin II and Actin in
Mitotic \bionameDictyostelium Cells . . 1793
Pascale Jordan and
Roger Karess Myosin Light Chain--activating
Phosphorylation Sites Are Required for
Oogenesis in \bionameDrosophila . . . . 1805
Gabriela Vaduva and
Nancy C. Martin and
Anita K. Hopper Actin-binding Verprolin Is a Polarity
Development Protein Required for the
Morphogenesis and Function of the Yeast
Actin Cytoskeleton . . . . . . . . . . . 1821
Christiana Ruhrberg and
M. A. Nasser Hajibagheri and
David A. D. Parry and
Fiona M. Watt Periplakin, a Novel Component of
Cornified Envelopes and Desmosomes That
Belongs to the Plakin Family and Forms
Complexes with Envoplakin . . . . . . . 1835
Peter Kueng and
Zariana Nikolova and
Valentin Djonov and
Andrew Hemphill and
Valeria Rohrbach and
Dominik Boehlen and
Gisela Zuercher and
Anne-Catherine Andres and
Andrew Ziemiecki A Novel Family of Serine/Threonine
Kinases Participating in Spermiogenesis 1851
André Lochter and
Sybille Galosy and
John Muschler and
Neal Freedman and
Zena Werb and
Mina J. Bissell Matrix Metalloproteinase Stromelysin-1
Triggers a Cascade of Molecular
Alterations That Leads to Stable
Epithelial--to--Mesenchymal Conversion
and a Premalignant Phenotype in Mammary
Epithelial Cells . . . . . . . . . . . . 1861
Isaac Rabinovitz and
Arthur M. Mercurio The Integrin $ \alpha $6$ \beta $4
Functions in Carcinoma Cell Migration on
Laminin-1 by Mediating the Formation and
Stabilization of Actin-containing
Motility Structures . . . . . . . . . . 1873
Nelson B. Cole and
Jan Ellenberg and
Jia Song and
Diane DiEuliis and
Jennifer Lippincott-Schwartz Retrograde Transport of Golgi-localized
Proteins to the ER . . . . . . . . . . . 1
Reinhard Gabathuler and
Judie Alimonti and
Qian-Jin Zhang and
Gerassimos Kolaitis and
Gregor Reid and
Wilfred A. Jefferies Surrogate Antigen Processing Mediated by
TAP-dependent Antigenic Peptide
Secretion . . . . . . . . . . . . . . . 17
Aaron M. Neiman Prospore Membrane Formation Defines a
Developmentally Regulated Branch of the
Secretory Pathway in Yeast . . . . . . . 29
Xiaohui Zha and
Lynda M. Pierini and
Philip L. Leopold and
Paul J. Skiba and
Ira Tabas and
Frederick R. Maxfield Sphingomyelinase Treatment Induces
ATP-independent Endocytosis . . . . . . 39
Bettina Huhse and
Peter Rehling and
Markus Albertini and
Lars Blank and
Karl Meller and
Wolf-H. Kunau Pex17p of \bionameSaccharomyces
cerevisiae Is a Novel Peroxin and
Component of the Peroxisomal Protein
Translocation Machinery . . . . . . . . 49
Christian Ungermann and
Benjamin J. Nichols and
Hugh R. B. Pelham and
William Wickner A Vacuolar v--t--SNARE Complex, the
Predominant Form In Vivo and on Isolated
Vacuoles, Is Disassembled and Activated
for Docking and Fusion . . . . . . . . . 61
Richard J. Cherry and
Keith M. Wilson and
Kathy Triantafilou and
Peter O'Toole and
Ian E. G. Morrison and
Patricia R. Smith and
Nelson Fernández Detection of Dimers of Dimers of Human
Leukocyte Antigen (HLA)--DR on the
Surface of Living Cells by
Single--Particle Fluorescence Imaging 71
Simon A. Rudge and
Andrew J. Morris and
JoAnne Engebrecht Relocalization of Phospholipase D
Activity Mediates Membrane Formation
During Meiosis . . . . . . . . . . . . . 81
Malini Vashishtha and
Thomas Phalen and
Marianne T. Marquardt and
Jae S. Ryu and
Alice C. Ng and
Margaret Kielian A Single Point Mutation Controls the
Cholesterol Dependence of Semliki Forest
Virus Entry and Exit . . . . . . . . . . 91
William Zerges and
Jean-David Rochaix Low Density Membranes Are Associated
with RNA-binding Proteins and Thylakoids
in the Chloroplast of Chlamydomonas
reinhardtii . . . . . . . . . . . . . . 101
Catherine Lindon and
Didier Montarras and
Christian Pinset Cell Cycle--regulated Expression of the
Muscle Determination Factor Myf5 in
Proliferating Myoblasts . . . . . . . . 111
Fumio Matsumura and
Shoichiro Ono and
Yoshihiko Yamakita and
Go Totsukawa and
Shigeko Yamashiro Specific Localization of Serine 19
Phosphorylated Myosin II during Cell
Locomotion and Mitosis of Cultured Cells 119
Helena Melander Gradin and
Niklas Larsson and
Ulrica Marklund and
Martin Gullberg Regulation of Microtubule Dynamics by
Extracellular Signals: cAMP-dependent
Protein Kinase Switches Off the Activity
of Oncoprotein 18 in Intact Cells . . . 131
Christopher M. Adams and
Michael G. Anderson and
David G. Motto and
Margaret P. Price and
Wayne A. Johnson and
Michael J. Welsh Ripped Pocket and Pickpocket, Novel
\bionameDrosophila DEG/ENaC Subunits
Expressed in Early Development and in
Mechanosensory Neurons . . . . . . . . . 143
Yasuki Ishizaki and
Michael D. Jacobson and
Martin C. Raff A Role for Caspases in Lens Fiber
Differentiation . . . . . . . . . . . . 153
Yohei Hirai and
André Lochter and
Sybille Galosy and
Shogo Koshida and
Shinichiro Niwa and
Mina J. Bissell Epimorphin Functions as a Key
Morphoregulator for Mammary Epithelial
Cells . . . . . . . . . . . . . . . . . 159
Yoshinori Aragane and
Dagmar Kulms and
Dieter Metze and
Gabriele Wilkes and
Birgit Pöppelmann and
Thomas A. Luger and
Thomas Schwarz Ultraviolet Light Induces Apoptosis via
Direct Activation of CD95 (Fas/APO-1)
Independently of Its Ligand CD95L . . . 171
Phoebe White and
Hermann Aberle and
Jean-Paul Vincent Signaling and Adhesion Activities of
Mammalian $ \beta $-Catenin and
Plakoglobin in \bionameDrosophila . . . 183
Jonathan M. G. Higgins and
Didier A. Mandlebrot and
Sunil K. Shaw and
Gary J. Russell and
Elizabeth A. Murphy and
Yih-Tai Chen and
W. James Nelson and
Christina M. Parker and
Michael B. Brenner Direct and Regulated Interaction of
Integrin $ \alpha_E \beta_7 $ with
E-Cadherin . . . . . . . . . . . . . . . 197
Leslie A. Cary and
Dong Cho Han and
Thomas R. Polte and
Steven K. Hanks and
Jun-Lin Guan Identification of p130$^{\rm Cas}$ as a
Mediator of Focal Adhesion
Kinase-promoted Cell Migration . . . . . 211
Noam E. Ziv and
Micha E. Spira Induction of Growth Cone Formation by
Transient and Localized Increases of
Intracellular Proteolytic Activity . . . 223
Peter Carmeliet and
Lieve Moons and
Mieke Dewerchin and
Steven Rosenberg and
Jean-Marc Herbert and
Florea Lupu and
Désiré Collen Receptor-independent Role of
Urokinase--Type Plasminogen Activator in
Pericellular Plasmin and Matrix
Metalloproteinase Proteolysis during
Vascular Wound Healing in Mice . . . . . 233
Yoshie Tange and
Tetsuya Horio and
Mizuki Shimanuki and
Da-Qiao Ding and
Yasushi Hiraoka and
Osami Niwa A Novel Fission Yeast Gene, tht1$^+$, Is
Required for the Fusion of Nuclear
Envelopes during Karyogamy . . . . . . . 247
Rohit Mahajan and
Larry Gerace and
Frauke Melchior Molecular Characterization of the SUMO-1
Modification of RanGAP1 and Its Role in
Nuclear Envelope Association . . . . . . 259
Xuequn Helen Hua and
John Newport Identification of a Preinitiation Step
in DNA Replication That Is Independent
of Origin Recognition Complex and cdc6,
but Dependent on cdk2 . . . . . . . . . 271
Jean-Claude Lozano and
Philippe Schatt and
François Marqu\`es and
Gérard Peaucellier and
Philippe Fort and
Jean-Pierre Féral and
Anne-Marie Genevi\`ere and
André Picard A Presumptive Developmental Role for a
Sea Urchin Cyclin B Splice Variant . . . 283
Elaine C. Davis and
Thomas J. Broekelmann and
Yuji Ozawa and
Robert P. Mecham Identification of Tropoelastin as a
Ligand for the 65-kD FK506-binding
Protein, FKBP65, in the Secretory
Pathway . . . . . . . . . . . . . . . . 295
Giulia Baldini and
Giovanna Baldini and
Guangyi Wang and
Mattew Weber and
Marina Zweyer and
Renato Bareggi and
Joan W. Witkin and
Alberto M. Martelli Expression of Rab3D N135I Inhibits
Regulated Secretion of ACTH in AtT-20
Cells . . . . . . . . . . . . . . . . . 305
Isabel Muñoz-Barroso and
Stewart Durell and
Kazuyasu Sakaguchi and
Ettore Appella and
Robert Blumenthal Dilation of the Human Immunodeficiency
Virus--1 Envelope Glycoprotein Fusion
Pore Revealed by the Inhibitory Action
of a Synthetic Peptide from gp41 . . . . 315
Aldebaran M. Hofer and
Cristina Fasolato and
Tullio Pozzan Capacitative Ca$^{2+}$ Entry Is Closely
Linked to the Filling State of Internal
Ca$^{2+}$ Stores: a Study Using
Simultaneous Measurements of I$_{\rm
CRAC}$ and Intraluminal [Ca$^{2+}$] . . 325
Stefan Wünsch and
Cecilia P. Sanchez and
Michael Gekle and
Lars Große-Wortmann and
Jochen Wiesner and
Michael Lanzer Differential Stimulation of the Na$^+$
/H$^+$ Exchanger Determines Chloroquine
Uptake in \bionamePlasmodium falciparum 335
Feizhou Liu and
Christopher C. Bauer and
Irving Ortiz and
Richard G. Cook and
Michael F. Schmid and
Henry F. Epstein $ \beta $-Filagenin, a Newly Identified
Protein Coassembling with Myosin and
Paramyosin in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 347
John Lippincott and
Rong Li Sequential Assembly of Myosin II, an
IQGAP-like Protein, and Filamentous
Actin to a Ring Structure Involved in
Budding Yeast Cytokinesis . . . . . . . 355
Thomas M. Roberts and
E. D. Salmon and
Murray Stewart Hydrostatic Pressure Shows That
Lamellipodial Motility in Ascaris Sperm
Requires Membrane-associated Major Sperm
Protein Filament Nucleation and
Elongation . . . . . . . . . . . . . . . 367
Rita K. Miller and
Mark D. Rose Kar9p Is a Novel Cortical Protein
Required for Cytoplasmic Microtubule
Orientation in Yeast . . . . . . . . . . 377
Fridoon J. Ahmad and
Christophe J. Echeverri and
Richard B. Vallee and
Peter W. Baas Cytoplasmic Dynein and Dynactin Are
Required for the Transport of
Microtubules into the Axon . . . . . . . 391
Thomas Moll and
Elisabetta Dejana and
Dietmar Vestweber In Vitro Degradation of Endothelial
Catenins by a Neutrophil Protease . . . 403
Motomi Enomoto-Iwamoto and
Masahiro Iwamoto and
Yoshiki Mukudai and
Yasuhiko Kawakami and
Tsutomu Nohno and
Yoshinobu Higuchi and
Seiji Takemoto and
Hideyo Ohuchi and
Sumihare Noji and
Kojiro Kurisu Bone Morphogenetic Protein Signaling Is
Required for Maintenance of
Differentiated Phenotype, Control of
Proliferation, and Hypertrophy in
Chondrocytes . . . . . . . . . . . . . . 409
Themis R. Kyriakides and
Yu-Hong Zhu and
Lynne T. Smith and
Steven D. Bain and
Zhantao Yang and
Ming T. Lin and
Keith G. Danielson and
Renato V. Iozzo and
Mary LaMarca and
Cindy E. McKinney and
Edward I. Ginns and
Paul Bornstein Mice That Lack Thrombospondin 2 Display
Connective Tissue Abnormalities That Are
Associated with Disordered Collagen
Fibrillogenesis, an Increased Vascular
Density, and a Bleeding Diathesis . . . 419
Timothy P. Skelton and
Chunxun Zeng and
Aaron Nocks and
Ivan Stamenkovic Glycosylation Provides Both Stimulatory
and Inhibitory Effects on Cell Surface
and Soluble CD44 Binding to Hyaluronan 431
Tin Tin Su and
Patrick H. O'Farrell Chromosome Association of Minichromosome
Maintenance Proteins in
\bionameDrosophila Endoreplication
Cycles . . . . . . . . . . . . . . . . . 451
Scott Erdman and
Li Lin and
Michael Malczynski and
Michael Snyder Pheromone-regulated Genes Required for
Yeast Mating Differentiation . . . . . . 461
Elena Oancea and
Mary N. Teruel and
Andrew F. G. Quest and
Tobias Meyer Green Fluorescent Protein (GFP)-tagged
Cysteine-rich Domains from Protein
Kinase C as Fluorescent Indicators for
Diacylglycerol Signaling in Living Cells 485
Michael J. Matunis and
Jian Wu and
Günter Blobel SUMO-1 Modification and Its Role in
Targeting the Ran GTPase-activating
Protein, RanGAP1, to the Nuclear Pore
Complex . . . . . . . . . . . . . . . . 499
Scott Happe and
Peggy Weidman Cell-free Transport to Distinct Golgi
Cisternae Is Compartment Specific and
ARF Independent . . . . . . . . . . . . 511
Laurence Abrami and
Marc Fivaz and
Pierre-Etienne Glauser and
Robert G. Parton and
F. van der Goot A Pore-forming Toxin Interacts with a
GPI-anchored Protein and Causes
Vacuolation of the Endoplasmic Reticulum 525
Harold D. Love and
Chung-Chih Lin and
Craig S. Short and
Joachim Ostermann Isolation of Functional Golgi-derived
Vesicles with a Possible Role in
Retrograde Transport . . . . . . . . . . 541
Alicia Llorente and
Andrzej Rapak and
Sandra L. Schmid and
Bo van Deurs and
Kirsten Sandvig Expression of Mutant Dynamin Inhibits
Toxicity and Transport of Endocytosed
Ricin to the Golgi Apparatus . . . . . . 553
Maria L. Wei and
Frank Bonzelius and
Rebecca M. Scully and
Regis B. Kelly and
Gary A. Herman GLUT4 and Transferrin Receptor Are
Differentially Sorted Along the
Endocytic Pathway in CHO Cells . . . . . 565
Wolfgang Voos and
Tom H. Stevens Retrieval of Resident Late-Golgi
Membrane Proteins from the Prevacuolar
Compartment of \bionameSaccharomyces
cerevisiae Is Dependent on the Function
of Grd19p . . . . . . . . . . . . . . . 577
Barbara M. Mullock and
Nicholas A. Bright and
Clare W. Fearon and
Sally R. Gray and
J. Luzio Fusion of Lysosomes with Late Endosomes
Produces a Hybrid Organelle of
Intermediate Density and Is NSF
Dependent . . . . . . . . . . . . . . . 591
Crislyn D'Souza-Schorey and
Elly van Donselaar and
Victor W. Hsu and
Chunzhi Yang and
Philip D. Stahl and
Peter J. Peters ARF6 Targets Recycling Vesicles to the
Plasma Membrane: Insights from an
Ultrastructural Investigation . . . . . 603
Concetta Lipardi and
Rosalia Mora and
Veronica Colomer and
Simona Paladino and
Lucio Nitsch and
Enrique Rodriguez-Boulan and
Chiara Zurzolo Caveolin Transfection Results in
Caveolae Formation but Not Apical
Sorting of Glycosylphosphatidylinositol
(GPI)-anchored Proteins in Epithelial
Cells . . . . . . . . . . . . . . . . . 617
Jason C. Mills and
Nicole L. Stone and
Joseph Erhardt and
Randall N. Pittman Apoptotic Membrane Blebbing Is Regulated
by Myosin Light Chain Phosphorylation 627
Josée N. Lavoie and
M. Nguyen and
R. C. Marcellus and
P. E. Branton and
G. C. Shore E4orf4, a Novel Adenovirus Death Factor
That Induces p53-independent Apoptosis
by a Pathway That Is Not Inhibited by
zVAD-fmk . . . . . . . . . . . . . . . . 637
Takeshi Matsui and
Masato Maeda and
Yoshinori Doi and
Shigenobu Yonemura and
Mutsuki Amano and
Kozo Kaibuchi and
Sachiko Tsukita and
Shoichiro Tsukita Rho-Kinase Phosphorylates COOH-terminal
Threonines of Ezrin/Radixin/Moesin (ERM)
Proteins and Regulates Their
Head-to-Tail Association . . . . . . . . 647
Takao Nakata and
Sumio Terada and
Nobutaka Hirokawa Visualization of the Dynamics of
Synaptic Vesicle and Plasma Membrane
Proteins in Living Axons . . . . . . . . 659
S. J. Wood and
C. R. Slater $ \beta $-Spectrin Is Colocalized with
Both Voltage-gated Sodium Channels and
Ankyrin$_G$ at the Adult Rat
Neuromuscular Junction . . . . . . . . . 675
Chung-Jiuan Jeng and
Steven A. McCarroll and
Thomas F. J. Martin and
Erik Floor and
James Adams and
David Krantz and
Stefan Butz and
Robert Edwards and
Erik S. Schweitzer Thy-1 Is a Component Common to Multiple
Populations of Synaptic Vesicles . . . . 685
Mairi P. Stewart and
Alison McDowall and
Nancy Hogg LFA-$1$-mediated Adhesion Is Regulated
by Cytoskeletal Restraint and by a
Ca$^{2+}$-dependent Protease, Calpain 699
Jiahua Xu and
Mary M. Zutter and
Samuel A. Santoro and
Richard A. F. Clark A Three-dimensional Collagen Lattice
Activates NF-$ \kappa $B in Human
Fibroblasts: Role in Integrin $ \alpha_2
$ Gene Expression and Tissue Remodeling 709
Rachael A. Clark and
Robert C. Fuhlbrigge and
Timothy A. Springer L-Selectin Ligands That Are O
-glycoprotease Resistant and Distinct
from MECA-79 Antigen are Sufficient for
Tethering and Rolling of Lymphocytes on
Human High Endothelial Venules . . . . . 721
J. Michael Lord and
Lynne M. Roberts Toxin Entry: Retrograde Transport
through the Secretory Pathway . . . . . 733
Huan-You Wang and
Wen Lin and
Jacqueline A. Dyck and
Joanne M. Yeakley and
Zhou Songyang and
Lewis C. Cantley and
Xiang-Dong Fu SRPK2: A Differentially Expressed SR
Protein-specific Kinase Involved in
Mediating the Interaction and
Localization of Pre-mRNA Splicing
Factors in Mammalian Cells . . . . . . . 737
Michel Dominguez and
Kurt Dejgaard and
Joachim Füllekrug and
Sophie Dahan and
Ali Fazel and
Jean-Pierre Paccaud and
David Y. Thomas and
John J. M. Bergeron and
Tommy Nilsson gp25L\slash emp24/p24 Protein Family
Members of the cis- Golgi Network Bind
Both COP I and II Coatomer . . . . . . . 751
Lilach Gilboa and
Rebecca G. Wells and
Harvey F. Lodish and
Yoav I. Henis Oligomeric Structure of Type I and Type
II Transforming Growth Factor $ \beta $
Receptors: Homodimers Form in the ER and
Persist at the Plasma Membrane . . . . . 767
Yisang Yoon and
Kelly R. Pitts and
Sophie Dahan and
Mark A. McNiven A Novel Dynamin-like Protein Associates
with Cytoplasmic Vesicles and Tubules of
the Endoplasmic Reticulum in Mammalian
Cells . . . . . . . . . . . . . . . . . 779
P. Scheiffele and
P. Verkade and
A. M. Fra and
H. Virta and
K. Simons and
E. Ikonen Caveolin-1 and -2 in the Exocytic
Pathway of MDCK Cells . . . . . . . . . 795
Ype Elgersma and
Minetta Elgersma-Hooisma and
Thibaut Wenzel and
J. Michael McCaffery and
Marilyn G. Farquhar and
Suresh Subramani A Mobile PTS2 Receptor for Peroxisomal
Protein Import in Pichia pastoris . . . 807
Arthur Partikian and
Bence Ölveczky and
R. Swaminathan and
Yuxin Li and
A. S. Verkman Rapid Diffusion of Green Fluorescent
Protein in the Mitochondrial Matrix . . 821
Feliciano Protasi and
Clara Franzini-Armstrong and
Paul D. Allen Role of Ryanodine Receptors in the
Assembly of Calcium Release Units in
Skeletal Muscle . . . . . . . . . . . . 831
R. A. Moore and
H. Nguyen and
J. Galceran and
I. N. Pessah and
P. D. Allen A Transgenic Myogenic Cell Line Lacking
Ryanodine Receptor Protein for
Homologous Expression Studies:
Reconstitution of Ry$_1$ R Protein and
Function . . . . . . . . . . . . . . . . 843
Karoly Trombitás and
Marion Greaser and
Siegfried Labeit and
Jian-Ping Jin and
Miklós Kellermayer and
Michiel Helmes and
Henk Granzier Titin Extensibility In Situ: Entropic
Elasticity of Permanently Folded and
Permanently Unfolded Molecular Segments 853
Bente Lowin-Kropf and
Virginia Smith Shapiro and
Arthur Weiss Cytoskeletal Polarization of T Cells Is
Regulated by an Immunoreceptor
Tyrosine-based Activation
Motif-dependent Mechanism . . . . . . . 861
S. H. Lillie and
S. S. Brown Smy1p, a Kinesin-related Protein That
Does Not Require Microtubules . . . . . 873
Shigenobu Yonemura and
Motohiro Hirao and
Yoshinori Doi and
Nobuyuki Takahashi and
Takahisa Kondo and
Sachiko Tsukita and
Shoichiro Tsukita Ezrin\slash Radixin\slash Moesin (ERM)
Proteins Bind to a Positively Charged
Amino Acid Cluster in the
Juxta--Membrane Cytoplasmic Domain of
CD44, CD43, and ICAM-2 . . . . . . . . . 885
Valerie A. Lantz and
Kathryn G. Miller A Class VI Unconventional Myosin Is
Associated with a Homologue of a
Microtubule-binding Protein, Cytoplasmic
Linker Protein--170, in Neurons and at
the Posterior Pole of \bionameDrosophila
Embryos . . . . . . . . . . . . . . . . 897
Shernaz X. Bamji and
Marta Majdan and
Christine D. Pozniak and
Daniel J. Belliveau and
Raquel Aloyz and
Judi Kohn and
Carrie G. Causing and
Freda D. Miller The p75 Neurotrophin Receptor Mediates
Neuronal Apoptosis and Is Essential for
Naturally Occurring Sympathetic Neuron
Death . . . . . . . . . . . . . . . . . 911
Alexander Gow and
Cherie M. Southwood and
Robert A. Lazzarini Disrupted Proteolipid Protein
Trafficking Results in Oligodendrocyte
Apoptosis in an Animal Model of
Pelizaeus--Merzbacher Disease . . . . . 925
Gerald F. Späth and
Mary C. Weiss Hepatocyte Nuclear Factor 4 Provokes
Expression of Epithelial Marker Genes,
Acting As a Morphogen in
Dedifferentiated Hepatoma Cells . . . . 935
Sybille Esser and
Karen Wolburg and
Hartwig Wolburg and
Georg Breier and
Teymuras Kurzchalia and
Werner Risau Vascular Endothelial Growth Factor
Induces Endothelial Fenestrations In
Vitro . . . . . . . . . . . . . . . . . 947
Richard L. Klemke and
Jie Leng and
Rachel Molander and
Peter C. Brooks and
Kristiina Vuori and
David A. Cheresh CAS\slash Crk Coupling Serves as a
``Molecular Switch'' for Induction of
Cell Migration . . . . . . . . . . . . . 961
Gang Li and
Gail Sudlow and
Andrew S. Belmont Interphase Cell Cycle Dynamics of a
Late-Replicating, Heterochromatic
Homogeneously Staining Region: Precise
Choreography of
Condensation/Decondensation and Nuclear
Positioning . . . . . . . . . . . . . . 975
Alastair M. Mackay and
Alexandra M. Ainsztein and
D. Mark Eckley and
William C. Earnshaw A Dominant Mutant of Inner Centromere
Protein (INCENP), a Chromosomal Protein,
Disrupts Prometaphase Congression and
Cytokinesis . . . . . . . . . . . . . . 991
Daniel P. Moore and
Andrea W. Page and
Tracy Tzu-Ling Tang and
Anne W. Kerrebrock and
Terry L. Orr-Weaver The Cohesion Protein MEI--S332 Localizes
to Condensed Meiotic and Mitotic
Centromeres until Sister Chromatids
Separate . . . . . . . . . . . . . . . . 1003
Birte Sönnichsen and
Martin Lowe and
Tim Levine and
Eija Jämsä and
Barbara Dirac-Svejstrup and
Graham Warren A Role for Giantin in Docking COPI
Vesicles to Golgi Membranes . . . . . . 1013
Shu-Hui Liu and
Michael S. Marks and
Frances M. Brodsky A Dominant-negative Clathrin Mutant
Differentially Affects Trafficking of
Molecules with Distinct Sorting Motifs
in the Class II Major Histocompatibility
Complex (MHC) Pathway . . . . . . . . . 1023
Paola Zacchi and
Harald Stenmark and
Robert G. Parton and
Donata Orioli and
Filip Lim and
Angelika Giner and
Ira Mellman and
Marino Zerial and
Carol Murphy Rab17 Regulates Membrane Trafficking
through Apical Recycling Endosomes in
Polarized Epithelial Cells . . . . . . . 1039
Alexandre Benmerah and
Christophe Lamaze and
Bernadette B\`egue and
Sandra L. Schmid and
Alice Dautry-Varsat and
Nadine Cerf-Bensussan AP-2\slash Eps15 Interaction Is Required
for Receptor-mediated Endocytosis . . . 1055
Yong-Xu Wang and
Natalie L. Catlett and
Lois S. Weisman Vac8p, a Vacuolar Protein with Armadillo
Repeats, Functions in both Vacuole
Inheritance and Protein Targeting from
the Cytoplasm to Vacuole . . . . . . . . 1063
Barry Press and
Yan Feng and
Bernard Hoflack and
Angela Wandinger-Ness Mutant Rab7 Causes the Accumulation of
Cathepsin D and Cation-independent
Mannose 6--Phosphate Receptor in an
Early Endocytic Compartment . . . . . . 1075
Andrey V. Kuznetsov and
Oleg Mayboroda and
Dagmar Kunz and
Kirstin Winkler and
Walter Schubert and
Wolfram S. Kunz Functional Imaging of Mitochondria in
Saponin-permeabilized Mice Muscle Fibers 1091
P. Rahkila and
V. Luukela and
K. Väänänen and
K. Metsikkö Differential Targeting of Vesicular
Stomatitis Virus G Protein and Influenza
Virus Hemagglutinin Appears During
Myogenesis of L6 Muscle Cells . . . . . 1101
Atsushi Suzuki and
Yuki Sugiyama and
Yukiko Hayashi and
Nobuo Nyu-i and
Michihiko Yoshida and
Ikuya Nonaka and
Sho-ichi Ishiura and
Kiichi Arahata and
Shigeo Ohno MKBP, a Novel Member of the Small Heat
Shock Protein Family, Binds and
Activates the Myotonic Dystrophy Protein
Kinase . . . . . . . . . . . . . . . . . 1113
Le Ma and
Lewis C. Cantley and
Paul A. Janmey and
Marc W. Kirschner Corequirement of Specific
Phosphoinositides and Small GTP-binding
Protein Cdc42 in Inducing Actin Assembly
in \bionameXenopus Egg Extracts . . . . 1125
Alistair Harrison and
Patricia Olds-Clarke and
Stephen M. King Identification of the t Complex--encoded
Cytoplasmic Dynein Light Chain Tctex1 in
Inner Arm I1 Supports the Involvement of
Flagellar Dyneins in Meiotic Drive . . . 1137
Stefan Geimer and
Judith Clees and
Michael Melkonian and
Karl-Ferdinand Lechtreck A Novel 95-kD Protein Is Located in a
Linker between Cytoplasmic Microtubules
and Basal Bodies in a Green Flagellate
and Forms Striated Filaments In Vitro 1149
Cay M. Kielty and
Michael Raghunath and
Linda D. Siracusa and
Michael J. Sherratt and
Reiner Peters and
C. Adrian Shuttleworth and
Sergio A. Jimenez The Tight Skin Mouse: Demonstration of
Mutant Fibrillin-1 Production and
Assembly into Abnormal Microfibrils . . 1159
Jiming Kong and
Vivian W.-Y. Tung and
John Aghajanian and
Zuoshang Xu Antagonistic Roles of Neurofilament
Subunits NF--H and NF--M Against NF--L
in Shaping Dendritic Arborization in
Spinal Motor Neurons . . . . . . . . . . 1167
Juan L. Brusés and
Urs Rutishauser Regulation of Neural Cell Adhesion
Molecule Polysialylation: Evidence for
Nontranscriptional Control and
Sensitivity to an Intracellular Pool of
Calcium . . . . . . . . . . . . . . . . 1177
Cynthia I. Foote and
Lan Zhou and
Xing Zhu and
Bruce J. Nicholson The Pattern of Disulfide Linkages in the
Extracellular Loop Regions of Connexin
32 Suggests a Model for the Docking
Interface of Gap Junctions . . . . . . . 1187
Friso R. Postma and
Trudi Hengeveld and
Jacqueline Alblas and
Ben N. G. Giepmans and
Gerben C. M. Zondag and
Kees Jalink and
Wouter H. Moolenaar Acute loss of Cell--Cell Communication
Caused by G Protein--coupled Receptors:
a Critical Role for c--Src . . . . . . . 1199
Sharon F. Clark and
Sally Martin and
Amanda J. Carozzi and
Michelle M. Hill and
David E. James Intracellular Localization of
Phosphatidylinositide $3$-kinase and
Insulin Receptor Substrate-1 in
Adipocytes: Potential Involvement of a
Membrane Skeleton . . . . . . . . . . . 1211
Yasushi Sako and
Akira Nagafuchi and
Shoichiro Tsukita and
Masatoshi Takeichi and
Akihiro Kusumi Cytoplasmic Regulation of the Movement
of E--Cadherin on the Free Cell Surface
as Studied by Optical Tweezers and
Single Particle Tracking: Corralling and
Tethering by the Membrane Skeleton . . . 1227
Ilka Ott and
Edgar G. Fischer and
Yohei Miyagi and
Barbara M. Mueller and
Wolfram Ruf A Role for Tissue Factor in Cell
Adhesion and Migration Mediated by
Interaction with Actin-binding Protein
280 . . . . . . . . . . . . . . . . . . 1241
Brian P. Eliceiri and
Richard Klemke and
Staffan Strömblad and
David A. Cheresh Integrin $ \alpha $ v$ \beta $3
Requirement for Sustained
Mitogen-activated Protein Kinase
Activity during Angiogenesis . . . . . . 1255
Traci L. Jesse and
Rhonda LaChance and
Michael F. Iademarco and
Douglas C. Dean Interferon Regulatory Factor-2 Is a
Transcriptional Activator in Muscle
Where It Regulates Expression of
Vascular Cell Adhesion Molecule-1 . . . 1265
George S. Bloom and
Lawrence S. B. Goldstein Cruising along Microtubule Highways: How
Membranes Move through the Secretory
Pathway . . . . . . . . . . . . . . . . 1277
Steven M. Block Leading the Procession: New Insights
into Kinesin Motors . . . . . . . . . . 1281
Dean A. Jackson and
Ana Pombo Replicon Clusters Are Stable Units of
Chromosome Structure: Evidence That
Nuclear Organization Contributes to the
Efficient Activation and Propagation of
S Phase in Human Cells . . . . . . . . . 1285
J. Suso Platero and
Amy K. Csink and
Adrian Quintanilla and
Steven Henikoff Changes in Chromosomal Localization of
Heterochromatin-binding Proteins during
the Cell Cycle in \bionameDrosophila . . 1297
Noriaki Shimizu and
Nobuo Itoh and
Hiroyasu Utiyama and
Geoffrey M. Wahl Selective Entrapment of
Extrachromosomally Amplified DNA by
Nuclear Budding and Micronucleation
during S Phase . . . . . . . . . . . . . 1307
Deborah J. Frank and
Mark B. Roth ncl-1 Is Required for the Regulation of
Cell Size and Ribosomal RNA Synthesis in
\bionameCaenorhabditis elegans . . . . . 1321
Andreas Krömer and
Michael M. Glombik and
Wieland B. Huttner and
Hans-Hermann Gerdes Essential Role of the Disulfide-bonded
Loop of Chromogranin B for Sorting to
Secretory Granules Is Revealed by
Expression of a Deletion Mutant in the
Absence of Endogenous Granin Synthesis 1331
Meng-Chieh Chiang and
Hui-Ling Chiang Vid24p, a Novel Protein Localized to the
Fructose-1,6-bisphosphatase--containing
Vesicles, Regulates Targeting of
Fructose-1,6-bisphosphatase from the
Vesicles to the Vacuole for Degradation 1347
Patrick Keller and
Kai Simons Cholesterol Is Required for Surface
Transport of Influenza Virus
Hemagglutinin . . . . . . . . . . . . . 1357
Leonid V. Chernomordik and
Vadim A. Frolov and
Eugenia Leikina and
Peter Bronk and
Joshua Zimmerberg The Pathway of Membrane Fusion Catalyzed
by Influenza Hemagglutinin: Restriction
of Lipids, Hemifusion, and Lipidic
Fusion Pore Formation . . . . . . . . . 1369
Kazufumi Honda and
Tesshi Yamada and
Ritsuko Endo and
Yoshinori Ino and
Masahiro Gotoh and
Hitoshi Tsuda and
Yozo Yamada and
Hiroshige Chiba and
Setsuo Hirohashi Actinin-4, a Novel Actin-bundling
Protein Associated with Cell Motility
and Cancer Invasion . . . . . . . . . . 1383
William O. Hancock and
Jonathon Howard Processivity of the Motor Protein
Kinesin Requires Two Heads . . . . . . . 1395
Laura Romberg and
Daniel W. Pierce and
Ronald D. Vale Role of the Kinesin Neck Region in
Processive Microtubule-based Motility 1407
Edward H. Hinchcliffe and
Grizzel O. Cassels and
Conly L. Rieder and
Greenfield Sluder The Coordination of Centrosome
Reproduction with Nuclear Events of the
Cell Cycle in the Sea Urchin Zygote . . 1417
Fabienne Depoortere and
Alexandra Van Keymeulen and
Jiri Lukas and
Sabine Costagliola and
Jirina Bartkova and
Jacques E. Dumont and
Jiri Bartek and
Pierre P. Roger and
Sarah Dremier A Requirement for Cyclin
D3--Cyclin-dependent Kinase (cdk)-4
Assembly in the Cyclic Adenosine
Monophosphate-dependent Proliferation of
Thyrocytes . . . . . . . . . . . . . . . 1427
Thomas M. Magin and
Rolf Schröder and
Sabine Leitgeb and
Frederique Wanninger and
Kurt Zatloukal and
Christine Grund and
David W. Melton Lessons from Keratin 18 Knockout Mice:
Formation of Novel Keratin Filaments,
Secondary Loss of Keratin 7 and
Accumulation of Liver-specific Keratin
8-Positive Aggregates . . . . . . . . . 1441
Heinz-Dieter Gabriel and
Dirk Jung and
Christoph Bützler and
Achim Temme and
Otto Traub and
Elke Winterhager and
Klaus Willecke Transplacental Uptake of Glucose Is
Decreased in Embryonic Lethal
Connexin26-deficient Mice . . . . . . . 1453
Robert E. Ward and
Rebecca S. Lamb and
Richard G. Fehon A Conserved Functional Domain of
\bionameDrosophila Coracle Is Required
for Localization at the Septate Junction
and Has Membrane-organizing Activity . . 1463
Pilar Navarro and
Luigi Ruco and
Elisabetta Dejana Differential Localization of VE- and
N--Cadherins in Human Endothelial Cells:
VE--Cadherin Competes with N--Cadherin
for Junctional Localization . . . . . . 1475
Marie Mancini and
Donald W. Nicholson and
Sophie Roy and
Nancy A. Thornberry and
Erin P. Peterson and
Livia A. Casciola-Rosen and
Antony Rosen The Caspase-3 Precursor Has a Cytosolic
and Mitochondrial Distribution:
Implications for Apoptotic Signaling . . 1485
Ruth S. Slack and
Hiba El-Bizri and
Josée Wong and
Daniel J. Belliveau and
Freda D. Miller A Critical Temporal Requirement for the
Retinoblastoma Protein Family During
Neuronal Determination . . . . . . . . . 1497
Andrew Pierce and
Clare M. Heyworth and
Sian E. Nicholls and
Elaine Spooncer and
T. Michael Dexter and
Janet M. Lord and
P. Jane Owen-Lynch and
Gwen Wark and
Anthony D. Whetton An Activated Protein Kinase C $ \alpha $
Gives a Differentiation Signal for
Hematopoietic Progenitor Cells and
Mimicks Macrophage Colony-stimulating
Factor--stimulated Signaling Events . . 1511
V. Cirulli and
L. Crisa and
G. M. Beattie and
M. I. Mally and
A. D. Lopez and
A. Fannon and
A. Ptasznik and
L. Inverardi and
C. Ricordi and
T. Deerinck and
M. Ellisman and
R. A. Reisfeld and
A. Hayek KSA Antigen Ep--CAM Mediates Cell--Cell
Adhesion of Pancreatic Epithelial Cells:
Morphoregulatory Roles in Pancreatic
Islet Development . . . . . . . . . . . 1519
Régis Masson and
Olivier Lefebvre and
Agn\`es Noël and
Mostapha El Fahime and
Marie-Pierre Chenard and
Corinne Wendling and
Florence Kebers and
Marianne LeMeur and
Andrée Dierich and
Jean-Michel Foidart and
Paul Basset and
Marie-Christine Rio In Vivo Evidence That the Stromelysin-3
Metalloproteinase Contributes in a
Paracrine Manner to Epithelial Cell
Malignancy . . . . . . . . . . . . . . . 1535
Steven R. Heidemann and
Robert E. Buxbaum Cell Crawling: First the Motor, Now the
Transmission . . . . . . . . . . . . . . 1
Jennifer C. Fung and
Wallace F. Marshall and
Abby Dernburg and
David A. Agard and
John W. Sedat Homologous Chromosome Pairing in
\bionameDrosophila melanogaster Proceeds
through Multiple Independent Initiations 5
Quan-wen Jin and
Edgar Trelles-Sticken and
Harry Scherthan and
Josef Loidl Yeast Nuclei Display Prominent
Centromere Clustering That Is Reduced in
Nondividing Cells and in Meiotic
Prophase . . . . . . . . . . . . . . . . 21
Sundeep Shah and
Stuart Tugendreich and
Douglass Forbes Major Binding Sites for the Nuclear
Import Receptor Are the Internal
Nucleoporin Nup153 and the Adjacent
Nuclear Filament Protein Tpr . . . . . . 31
A. Harada and
Y. Takei and
Y. Kanai and
Y. Tanaka and
S. Nonaka and
N. Hirokawa Golgi Vesiculation and Lysosome
Dispersion in Cells Lacking Cytoplasmic
Dynein . . . . . . . . . . . . . . . . . 51
Meir Aridor and
Jacques Weissman and
Sergei Bannykh and
Claude Nuoffer and
William E. Balch Cargo Selection by the COPII Budding
Machinery during Export from the ER . . 61
Beverly Wendland and
Scott D. Emr Pan1p, Yeast eps15, Functions as a
Multivalent Adaptor That Coordinates
Protein--Protein Interactions Essential
for Endocytosis . . . . . . . . . . . . 71
John R. Henley and
Eugene W. A. Krueger and
Barbara J. Oswald and
Mark A. McNiven Dynamin-mediated Internalization of
Caveolae . . . . . . . . . . . . . . . . 85
Phil Oh and
Deirdre P. McIntosh and
Jan E. Schnitzer Dynamin at the Neck of Caveolae Mediates
Their Budding to Form Transport Vesicles
by GTP-driven Fission from the Plasma
Membrane of Endothelium . . . . . . . . 101
Gudrun Ihrke and
Greg V. Martin and
Michael R. Shanks and
Michael Schrader and
Trina A. Schroer and
Ann L. Hubbard Apical Plasma Membrane Proteins and
Endolyn-78 Travel through a Subapical
Compartment in Polarized WIF--B
Hepatocytes . . . . . . . . . . . . . . 115
Miki Yamamoto-Hino and
Atsushi Miyawaki and
Akihisa Segawa and
Eijiro Adachi and
Shohei Yamashina and
Toyoshi Fujimoto and
Tomoyasu Sugiyama and
Teiichi Furuichi and
Mamoru Hasegawa and
Katsuhiko Mikoshiba Apical Vesicles Bearing Inositol
1,4,5-trisphosphate Receptors in the
Ca$^{2+}$ Initiation Site of Ductal
Epithelium of Submandibular Gland . . . 135
Loren D. Walensky and
Philippe Gascard and
Michael E. Field and
Seth Blackshaw and
John G. Conboy and
Narla Mohandas and
Solomon H. Snyder The 13-kD FK506 Binding Protein, FKBP13,
Interacts with a Novel Homologue of the
Erythrocyte Membrane Cytoskeletal
Protein 4.1 . . . . . . . . . . . . . . 143
James D. Jontes and
E. Michael Ostap and
Thomas D. Pollard and
Ronald A. Milligan Three-dimensional Structure of
Acanthamoeba castellanii Myosin--IB
(MIB) Determined by Cryoelectron
Microscopy of Decorated Actin Filaments 155
Jason B. Dictenberg and
Wendy Zimmerman and
Cynthia A. Sparks and
Aaron Young and
Charles Vidair and
Yixian Zheng and
Walter Carrington and
Fredric S. Fay and
Stephen J. Doxsey Pericentrin and $ \gamma $-Tubulin Form
a Protein Complex and Are Organized into
a Novel Lattice at the Centrosome . . . 163
Tiffani A. Cook and
Takayuki Nagasaki and
Gregg G. Gundersen Rho Guanosine Triphosphatase Mediates
the Selective Stabilization of
Microtubules Induced by Lysophosphatidic
Acid . . . . . . . . . . . . . . . . . . 175
Catherine D. Nobes and
Inger Lauritzen and
Marie-Genevi\`eve Mattei and
Sonia Paris and
Alan Hall and
Pierre Chardin A New Member of the Rho Family, Rnd1,
Promotes Disassembly of Actin Filament
Structures and Loss of Cell Adhesion . . 187
Julie Haskins and
Lijie Gu and
Erika S. Wittchen and
Jennifer Hibbard and
Bruce R. Stevenson ZO-3, a Novel Member of the MAGUK
Protein Family Found at the Tight
Junction, Interacts with ZO-1 and
Occludin . . . . . . . . . . . . . . . . 199
Günther A. Rezniczek and
José M. de Pereda and
Siegfried Reipert and
Gerhard Wiche Linking Integrin $ \alpha_6 \beta_4
$-based Cell Adhesion to the
Intermediate Filament Cytoskeleton:
Direct Interaction between the $ \beta_4
$ Subunit and Plectin at Multiple
Molecular Sites . . . . . . . . . . . . 209
Daniel M. Suter and
Laura D. Errante and
Victoria Belotserkovsky and
Paul Forscher The Ig Superfamily Cell Adhesion
Molecule, apCAM, Mediates Growth Cone
Steering by Substrate--Cytoskeletal
Coupling . . . . . . . . . . . . . . . . 227
Denise C. Hocking and
Jane Sottile and
Paula J. McKeown-Longo Activation of Distinct $ \alpha_5
\beta_1$-mediated Signaling Pathways by
Fibronectin's Cell Adhesion and Matrix
Assembly Domains . . . . . . . . . . . . 241
Lawrence E. Goldfinger and
M. Sharon Stack and
Jonathan C. R. Jones Processing of Laminin-5 and Its
Functional Consequences: Role of Plasmin
and Tissue-type Plasminogen Activator 255
Christoph Claas and
Simone Seiter and
Andreas Claas and
Larissa Savelyeva and
Manfred Schwab and
Margot Zöller Association Between the Rat Homologue of
CO-029, a Metastasis-associated
Tetraspanin Molecule and Consumption
Coagulopathy . . . . . . . . . . . . . . 267
Albrecht Lepple-Wienhues and
Ildik\`o Szab\`o and
Tilmann Laun and
Nubia Kristen Kaba and
Erich Gulbins and
Florian Lang The Tyrosine Kinase p56 $^{\rm lck}$
Mediates Activation of Swelling-induced
Chloride Channels in Lymphocytes . . . . 281
Susann M. Brady-Kalnay and
Tracy Mourton and
Joseph P. Nixon and
Gregory E. Pietz and
Michael Kinch and
Haiyan Chen and
Robert Brackenbury and
David L. Rimm and
Robert L. Del Vecchio and
Nicholas K. Tonks Dynamic Interaction of PTP$ \mu $ with
Multiple Cadherins In Vivo . . . . . . . 287
Michael Costa and
William Raich and
Cristina Agbunag and
Ben Leung and
Jeff Hardin and
James R. Priess A Putative Catenin--Cadherin System
Mediates Morphogenesis of the
\bionameCaenorhabditis elegans Embryo 297
Damien F. Hudson and
Kerry J. Fowler and
Elizabeth Earle and
Richard Saffery and
Paul Kalitsis and
Helen Trowell and
Joanne Hill and
Nigel G. Wreford and
David M. de Kretser and
Michael R. Cancilla and
Emily Howman and
Linda Hii and
Suzanne M. Cutts and
Danielle V. Irvine and
K. H. A. Choo Centromere Protein B Null Mice are
Mitotically and Meiotically Normal but
Have Lower Body and Testis Weights . . . 309
Cristina Machado and
Claudio E. Sunkel and
Deborah J. Andrew Human Autoantibodies Reveal Titin as a
Chromosomal Protein . . . . . . . . . . 321
Ian de Belle and
Shutao Cai and
Terumi Kohwi-Shigematsu The Genomic Sequences Bound to Special
AT-rich Sequence-binding Protein 1
(SATB1) In Vivo in Jurkat T Cells Are
Tightly Associated with the Nuclear
Matrix at the Bases of the Chromatin
Loops . . . . . . . . . . . . . . . . . 335
Linda Hicke and
Bettina Zanolari and
Howard Riezman Cytoplasmic Tail Phosphorylation of the
$ \alpha $-Factor Receptor Is Required
for Its Ubiquitination and
Internalization . . . . . . . . . . . . 349
Judith Klumperman and
Regina Kuliawat and
Janice M. Griffith and
Hans J. Geuze and
Peter Arvan Mannose 6--Phosphate Receptors Are
Sorted from Immature Secretory Granules
via Adaptor Protein AP-1, Clathrin, and
Syntaxin $6$--positive Vesicles . . . . 359
Michael Passreiter and
Markus Anton and
Dorothee Lay and
Rainer Frank and
Cordula Harter and
Felix T. Wieland and
Karin Gorgas and
Wilhelm W. Just Peroxisome Biogenesis: Involvement of
ARF and Coatomer . . . . . . . . . . . . 373
Laura M. Roy and
Alice Barkan A SecY Homologue Is Required for the
Elaboration of the Chloroplast Thylakoid
Membrane and for Normal Chloroplast Gene
Expression . . . . . . . . . . . . . . . 385
Mitinori Saitou and
Kazushi Fujimoto and
Yoshinori Doi and
Masahiko Itoh and
Toyoshi Fujimoto and
Mikio Furuse and
Hiroshi Takano and
Tetsuo Noda and
Shoichiro Tsukita Occludin-deficient Embryonic Stem Cells
Can Differentiate into Polarized
Epithelial Cells Bearing Tight Junctions 397
Yuko Fukata and
Kazushi Kimura and
Noriko Oshiro and
Hideyuki Saya and
Yoshiharu Matsuura and
Kozo Kaibuchi Association of the Myosin-binding
Subunit of Myosin Phosphatase and
Moesin: Dual Regulation of Moesin
Phosphorylation by Rho-associated Kinase
and Myosin Phosphatase . . . . . . . . . 409
A. Hoenger and
S. Sack and
M. Thormählen and
A. Marx and
J. Müller and
H. Gross and
E. Mandelkow Image Reconstructions of Microtubules
Decorated with Monomeric and Dimeric
Kinesins: Comparison with X--Ray
Structure and Implications for Motility 419
Yoshiaki Yonekawa and
Akihiro Harada and
Yasushi Okada and
Takeshi Funakoshi and
Yoshimitsu Kanai and
Yosuke Takei and
Sumio Terada and
Tetsuo Noda and
Nobutaka Hirokawa Defect in Synaptic Vesicle Precursor
Transport and Neuronal Cell Death in
KIF1A Motor Protein--deficient Mice . . 431
Joseph G. Gindhart and
Chand J. Desai and
Sven Beushausen and
Kai Zinn and
Lawrence S. B. Goldstein Kinesin Light Chains Are Essential for
Axonal Transport in \bionameDrosophila 443
Kaijun Li and
Eugene Yujun Xu and
Jeffrey K. Cecil and
F. Rudolf Turner and
Timothy L. Megraw and
Thomas C. Kaufman Drosophila Centrosomin Protein is
Required for Male Meiosis and Assembly
of the Flagellar Axoneme . . . . . . . . 455
Peter Buchenau and
Jacob Hodgson and
Helen Strutt and
Donna J. Arndt-Jovin The Distribution of Polycomb--Group
Proteins During Cell Division and
Development in \bionameDrosophila
Embryos: Impact on Models for Silencing 469
Noel Gerald and
Jianwu Dai and
H. Ping Ting-Beall and
Arturo De Lozanne A Role for \bionameDictyostelium RacE in
Cortical Tension and Cleavage Furrow
Progression . . . . . . . . . . . . . . 483
Marjorie Gondré and
Patrick Burrola and
David E. Weinstein Accelerated Nerve Regeneration Mediated
by Schwann Cells Expressing a Mutant
Form of the POU Protein SCIP . . . . . . 493
James Brugarolas and
Roderick T. Bronson and
Tyler Jacks p21 Is a Critical CDK2 Regulator
Essential for Proliferation Control in
Rb -deficient Cells . . . . . . . . . . 503
Anna Huttenlocher and
Margot Lakonishok and
Melissa Kinder and
Stanley Wu and
Tho Truong and
Karen A. Knudsen and
Alan F. Horwitz Integrin and Cadherin Synergy Regulates
Contact Inhibition of Migration and
Motile Activity . . . . . . . . . . . . 515
Takao Sakai and
Qinghong Zhang and
Reinhard Fässler and
Deane F. Mosher Modulation of $ \beta $1A Integrin
Functions by Tyrosine Residues in the $
\beta $1 Cytoplasmic Domain . . . . . . 527
Cuiling Zhong and
Magdalena Chrzanowska-Wodnicka and
James Brown and
Amy Shaub and
Alexey M. Belkin and
Keith Burridge Rho-mediated Contractility Exposes a
Cryptic Site in Fibronectin and Induces
Fibronectin Matrix Assembly . . . . . . 539
Tae-Aug Kim and
Jinkyu Lim and
Setsuo Ota and
Sandhya Raja and
Rick Rogers and
Benjamin Rivnay and
Hava Avraham and
Shalom Avraham NRP\slash B, a Novel Nuclear Matrix
Protein, Associates With p110$^{\rm RB}$
and Is Involved in Neuronal
Differentiation . . . . . . . . . . . . 553
Valeria Brizzio and
Alison E. Gammie and
Mark D. Rose Rvs161p Interacts with Fus2p to Promote
Cell Fusion in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 567
Xiaobo Du and
J. Daniel Stoops and
James R. Mertz and
C. Michael Stanley and
Joseph L. Dixon Identification of Two Regions in
Apolipoprotein B100 that are Exposed on
the Cytosolic Side of the Endoplasmic
Reticulum Membrane . . . . . . . . . . . 585
Chieko Mineo and
Yun-Shu Ying and
Christine Chapline and
Susan Jaken and
Richard G. W. Anderson Targeting of Protein Kinase C$ \alpha $
to Caveolae . . . . . . . . . . . . . . 601
C. E. Futter and
A. Gibson and
E. H. Allchin and
S. Maxwell and
L. J. Ruddock and
G. Odorizzi and
D. Domingo and
I. S. Trowbridge and
C. R. Hopkins In Polarized MDCK Cells Basolateral
Vesicles Arise from Clathrin-$ \gamma
$-adaptin-coated Domains on Endosomal
Tubules . . . . . . . . . . . . . . . . 611
Yasuyoshi Sakai and
Antonius Koller and
Linda K. Rangell and
Gilbert A. Keller and
Suresh Subramani Peroxisome Degradation by Microautophagy
in Pichia pastoris: Identification of
Specific Steps and Morphological
Intermediates . . . . . . . . . . . . . 625
Joseph Bass and
Gavin Chiu and
Yair Argon and
Donald F. Steiner Folding of Insulin Receptor Monomers Is
Facilitated by the Molecular Chaperones
Calnexin and Calreticulin and Impaired
by Rapid Dimerization . . . . . . . . . 637
David A. Potter and
Jennifer S. Tirnauer and
Richard Janssen and
Dorothy E. Croall and
Christina N. Hughes and
Kerry A. Fiacco and
James W. Mier and
Masatoshi Maki and
Ira M. Herman Calpain Regulates Actin Remodeling
during Cell Spreading . . . . . . . . . 647
Steven M. Murphy and
Lenore Urbani and
Tim Stearns The Mammalian $ \gamma $-Tubulin Complex
Contains Homologues of the Yeast Spindle
Pole Body Components Spc97p and Spc98p 663
Ona C. Martin and
Ruwanthi N. Gunawardane and
Akihiro Iwamatsu and
Yixian Zheng Xgrip109: a $ \gamma $
Tubulin--Associated Protein with an
Essential Role in $ \gamma $ Tubulin
Ring Complex ($ \gamma $TuRC) Assembly
and Centrosome Function . . . . . . . . 675
Anne-Marie Tassin and
Claude Celati and
Mohammed Moudjou and
Michel Bornens Characterization of the Human Homologue
of the Yeast Spc98p and Its Association
with $ \gamma $-Tubulin . . . . . . . . 689
Arshad Desai and
Paul S. Maddox and
Timothy J. Mitchison and
E. D. Salmon Anaphase A Chromosome Movement and
Poleward Spindle Microtubule Flux Occur
At Similar Rates in \bionameXenopus
Extract Spindles . . . . . . . . . . . . 703
Thomas Meier and
Fabrizio Masciulli and
Chris Moore and
Fabrice Schoumacher and
Urs Eppenberger and
Alain J. Denzer and
Graham Jones and
Hans Rudolf Brenner Agrin Can Mediate Acetylcholine Receptor
Gene Expression in Muscle by Aggregation
of Muscle-derived Neuregulins . . . . . 715
Gregory A. Elder and
Victor L. Friedrich and
Paolo Bosco and
Chulho Kang and
Andrei Gourov and
Pang-Hsien Tu and
Virginia M.-Y. Lee and
Robert A. Lazzarini Absence of the Mid-sized Neurofilament
Subunit Decreases Axonal Calibers,
Levels of Light Neurofilament (NF--L),
and Neurofilament Content . . . . . . . 727
Honami Naora and
Izumi Takai and
Masakazu Adachi and
Hiroto Naora Altered Cellular Responses by Varying
Expression of a Ribosomal Protein Gene:
Sequential Coordination of Enhancement
and Suppression of Ribosomal Protein S3a
Gene Expression Induces Apoptosis . . . 741
Elisabeth E. Weiss and
Martina Kroemker and
Angelika-H. Rüdiger and
Brigitte M. Jockusch and
Manfred Rüdiger Vinculin Is Part of the
Cadherin--Catenin Junctional Complex:
Complex Formation between $ \alpha
$-Catenin and Vinculin . . . . . . . . . 755
Melissa H. Wong and
Bonnee Rubinfeld and
Jeffrey I. Gordon Effects of Forced Expression of an
NH$_2$-terminal Truncated $ \beta
$-Catenin on Mouse Intestinal Epithelial
Homeostasis . . . . . . . . . . . . . . 765
Alpha S. Yap and
Carien M. Niessen and
Barry M. Gumbiner The Juxtamembrane Region of the Cadherin
Cytoplasmic Tail Supports Lateral
Clustering, Adhesive Strengthening, and
Interaction with p120$^{\rm ctn}$ . . . 779
María Yáñez-Mó and
Arántzazu Alfranca and
Carlos Cabañas and
Mónica Marazuela and
Reyes Tejedor and
M. Angeles Ursa and
Leonie K. Ashman and
Manuel O. de Landázuri and
Francisco Sánchez-Madrid Regulation of Endothelial Cell Motility
by Complexes of Tetraspan Molecules
CD81/TAPA-1 and CD151/PETA-3 with $
\alpha $3$ \beta $1 Integrin Localized
at Endothelial Lateral Junctions . . . . 791
Karen K. Hirschi and
Stephanie A. Rohovsky and
Patricia A. D'Amore PDGF, TGF-$ \beta $, and Heterotypic
Cell--Cell Interactions Mediate
Endothelial Cell-induced Recruitment of
10T1/2 Cells and Their Differentiation
to a Smooth Muscle Fate . . . . . . . . 805
Anders Nykjær and
Erik I. Christensen and
Henrik Vorum and
Henrik Hager and
Claus M. Petersen and
Hans Ròigaard and
Hye Y. Min and
Frederik Vilhardt and
Lisbeth B. Mòller and
Stuart Kornfeld and
Jòrgen Gliemann Mannose 6-Phosphate/Insulin-like Growth
Factor-II Receptor Targets the Urokinase
Receptor to Lysosomes via a Novel
Binding Interaction . . . . . . . . . . 815
T. J. Wess and
P. P. Purslow and
M. J. Sherratt and
J. Ashworth and
C. A. Shuttleworth and
C. M. Kielty Calcium Determines the Supramolecular
Organization of Fibrillin-rich
Microfibrils . . . . . . . . . . . . . . 829
Mikael Wendel and
Yngve Sommarin and
Dick Heinegård Bone Matrix Proteins: Isolation and
Characterization of a Novel Cell-binding
Keratan Sulfate Proteoglycan
(Osteoadherin) from Bovine Bone . . . . 839
Denis Dujardin and
U. Irene Wacker and
Anne Moreau and
Trina A. Schroer and
Janet E. Rickard and
Jan R. De Mey Evidence for a Role of CLIP-170 in the
Establishment of Metaphase Chromosome
Alignment . . . . . . . . . . . . . . . 849
Ralph H. Kehlenbach and
Achim Dickmanns and
Larry Gerace Nucleocytoplasmic Shuttling Factors
Including Ran and CRM1 Mediate Nuclear
Export of NFAT In Vitro . . . . . . . . 863
Pei Jin and
Stephen Hardy and
David O. Morgan Nuclear Localization of Cyclin B1
Controls Mitotic Entry After DNA Damage 875
Kai-Uwe Kalies and
Tom A. Rapoport and
Enno Hartmann The $ \beta $ Subunit of the Sec61
Complex Facilitates Cotranslational
Protein Transport and Interacts with the
Signal Peptidase during Translocation 887
Timo May and
Jürgen Soll Positive Charges Determine the Topology
and Functionality of the Transmembrane
Domain in the Chloroplastic Outer
Envelope Protein Toc34 . . . . . . . . . 895
Palmer A. Orlandi and
Peter H. Fishman Filipin-dependent Inhibition of Cholera
Toxin: Evidence for Toxin
Internalization and Activation through
Caveolae-like Domains . . . . . . . . . 905
Anne A. Wolf and
Michael G. Jobling and
Susan Wimer-Mackin and
Margaret Ferguson-Maltzman and
James L. Madara and
Randall K. Holmes and
Wayne I. Lencer Ganglioside Structure Dictates Signal
Transduction by Cholera Toxin and
Association with Caveolae-like Membrane
Domains in Polarized Epithelia . . . . . 917
Thomas Harder and
Peter Scheiffele and
Paul Verkade and
Kai Simons Lipid Domain Structure of the Plasma
Membrane Revealed by Patching of
Membrane Components . . . . . . . . . . 929
Carol A. Sartorius and
Brian D. Lu and
Leslie Acakpo-Satchivi and
Renee P. Jacobsen and
William C. Byrnes and
Leslie A. Leinwand Myosin Heavy Chains IIa and IId Are
Functionally Distinct in the Mouse . . . 943
David T. Shima and
Noemí Cabrera-Poch and
Rainer Pepperkok and
Graham Warren An Ordered Inheritance Strategy for the
Golgi Apparatus: Visualization of
Mitotic Disassembly Reveals a Role for
the Mitotic Spindle . . . . . . . . . . 955
Philip A. Wigge and
Ole N. Jensen and
Simon Holmes and
Sylvie Sou\`es and
Matthias Mann and
John V. Kilmartin Analysis of the \bionameSaccharomyces
Spindle Pole by Matrix-assisted Laser
Desorption/Ionization (MALDI) Mass
Spectrometry . . . . . . . . . . . . . . 967
Gregory J. Pazour and
Curtis G. Wilkerson and
George B. Witman A Dynein Light Chain Is Essential for
the Retrograde Particle Movement of
Intraflagellar Transport (IFT) . . . . . 979
Douglas G. Cole and
Dennis R. Diener and
Amy L. Himelblau and
Peter L. Beech and
Jason C. Fuster and
Joel L. Rosenbaum \bionameChlamydomonas
Kinesin-II-dependent Intraflagellar
Transport (IFT): IFT Particles Contain
Proteins Required for Ciliary Assembly
in \bionameCaenorhabditis elegans
Sensory Neurons . . . . . . . . . . . . 993
Laura Torroja and
Daniel Ortuño-Sahagún and
Alberto Ferrús and
Barbara Hämmerle and
Julio A. Barbas scully, an Essential Gene of
\bionameDrosophila, is Homologous to
Mammalian Mitochondrial Type II
l-3-hydroxyacyl-CoA
Dehydrogenase/Amyloid-$ \beta $
Peptide-binding Protein . . . . . . . . 1009
Michelle L. Matter and
Zhuohua Zhang and
Christer Nordstedt and
Erkki Ruoslahti The $ \alpha $5$ \beta $1 Integrin
Mediates Elimination of Amyloid-$ \beta
$ Peptide and Protects Against Apoptosis 1019
Daniel M. Skovronsky and
Robert W. Doms and
Virginia M.-Y. Lee Detection of a Novel Intraneuronal Pool
of Insoluble Amyloid $ \beta $ Protein
that Accumulates with Time in Culture 1031
Oliver Wessely and
Eva-Maria Deiner and
Kim Chew Lim and
Georg Mellitzer and
Peter Steinlein and
Hartmut Beug Mammalian Granulocyte--Macrophage
Colony-stimulating Factor Receptor
Expressed in Primary Avian Hematopoietic
Progenitors: Lineage-specific Regulation
of Proliferation and Differentiation . . 1041
James J. Campbell and
Edward P. Bowman and
Kristine Murphy and
Kenneth R. Youngman and
Michael A. Siani and
Darren A. Thompson and
Lijun Wu and
Albert Zlotnik and
Eugene C. Butcher $6$-C-kine (SLC), a Lymphocyte
Adhesion-triggering Chemokine Expressed
by High Endothelium, Is an Agonist for
the MIP-3$ \beta $ Receptor CCR7 . . . . 1053
Maria Guttinger and
Francesca Sutti and
Maddalena Panigada and
Simona Porcellini and
Barbara Merati and
Margherita Mariani and
Tambet Teesalu and
G. Giacomo Consalez and
Fabio Grassi Epithelial V-like Antigen (EVA), a Novel
Member of the Immunoglobulin
Superfamily, Expressed in Embryonic
Epithelia with a Potential Role as
Homotypic Adhesion Molecule in Thymus
Histogenesis . . . . . . . . . . . . . . 1061
Maria D. Martin-Bermudo and
Olga M. Dunin-Borkowski and
Nicholas H. Brown Modulation of Integrin Activity is Vital
for Morphogenesis . . . . . . . . . . . 1073
Marta Scatena and
Manuela Almeida and
Michelle L. Chaisson and
Nelson Fausto and
Roberto F. Nicosia and
Cecilia M. Giachelli NF-$ \kappa $B Mediates $ \alpha $ v$
\beta $3 Integrin-induced Endothelial
Cell Survival . . . . . . . . . . . . . 1083
Abigail S. Hackam and
Roshni Singaraja and
Cheryl L. Wellington and
Martina Metzler and
Krista McCutcheon and
Taiqi Zhang and
Michael Kalchman and
Michael R. Hayden The Influence of Huntingtin Protein Size
on Nuclear Localization and Cellular
Toxicity . . . . . . . . . . . . . . . . 1097
Susan M. VanRheenen and
Xiaochun Cao and
Vladimir V. Lupashin and
Charles Barlowe and
M. Gerard Waters Sec35p, a Novel Peripheral Membrane
Protein, Is Required for ER to Golgi
Vesicle Docking . . . . . . . . . . . . 1107
Wolfgang Faigle and
Graça Raposo and
Daniele Tenza and
Valérie Pinet and
Anne B. Vogt and
Harald Kropshofer and
Alain Fischer and
Genevi\`eve de Saint-Basile and
Sebastian Amigorena Deficient Peptide Loading and MHC Class
II Endosomal Sorting in a Human Genetic
Immunodeficiency Disease: the
Chediak--Higashi Syndrome . . . . . . . 1121
Sudipto Roy and
K. VijayRaghavan Patterning Muscles Using Organizers:
Larval Muscle Templates and Adult
Myoblasts Actively Interact to Pattern
the Dorsal Longitudinal Flight Muscles
of \bionameDrosophila . . . . . . . . . 1135
William E. Allen and
Daniel Zicha and
Anne J. Ridley and
Gareth E. Jones A Role for Cdc42 in Macrophage
Chemotaxis . . . . . . . . . . . . . . . 1147
Lisa R. Matthews and
Philip Carter and
Danielle Thierry-Mieg and
Ken Kemphues ZYG-9, A \bionameCaenorhabditis elegans
Protein Required for Microtubule
Organization and Function, Is a
Component of Meiotic and Mitotic Spindle
Poles . . . . . . . . . . . . . . . . . 1159
Xiaoyue Peter Chen and
Hongwei Yin and
Tim C. Huffaker The Yeast Spindle Pole Body Component
Spc72p Interacts with Stu2p and Is
Required for Proper Microtubule Assembly 1169
Jennifer C. Waters and
Rey-Huei Chen and
Andrew W. Murray and
E. D. Salmon Localization of Mad2 to Kinetochores
Depends on Microtubule Attachment, Not
Tension . . . . . . . . . . . . . . . . 1181
Gary J. Gorbsky and
Rey-Huei Chen and
Andrew W. Murray Microinjection of Antibody to Mad2
Protein into Mammalian Cells in Mitosis
Induces Premature Anaphase . . . . . . . 1193
Paul R. Andreassen and
Françoise B. Lacroix and
Emma Villa-Moruzzi and
Robert L. Margolis Differential Subcellular Localization of
Protein Phosphatase-1 $ \alpha $, $
\gamma $1, and $ \delta $ Isoforms
during Both Interphase and Mitosis in
Mammalian Cells . . . . . . . . . . . . 1207
Janni Petersen and
Olaf Nielsen and
Richard Egel and
Iain M. Hagan FH3, A Domain Found in Formins, Targets
the Fission Yeast Formin Fus1 to the
Projection Tip During Conjugation . . . 1217
Elizabeth A. Smith and
Elaine Fuchs Defining the Interactions Between
Intermediate Filaments and Desmosomes 1229
Richard M. Siegel and
David A. Martin and
Lixin Zheng and
Samuel Y. Ng and
John Bertin and
Jeffrey Cohen and
Michael J. Lenardo Death-effector Filaments: Novel
Cytoplasmic Structures that Recruit
Caspases and Trigger Apoptosis . . . . . 1243
Denise Perez and
Eileen White E1B 19K Inhibits Fas-mediated Apoptosis
through FADD-dependent Sequestration of
FLICE . . . . . . . . . . . . . . . . . 1255
Marc Chanson and
Marjorie Fanjul and
Domenico Bosco and
Eric Nelles and
Susanne Suter and
Klaus Willecke and
Paolo Meda Enhanced Secretion of Amylase from
Exocrine Pancreas of
Connexin32-deficient Mice . . . . . . . 1267
Shukti Chakravarti and
Terry Magnuson and
Jonathan H. Lass and
Karl J. Jepsen and
Christian LaMantia and
Heidi Carroll Lumican Regulates Collagen Fibril
Assembly: Skin Fragility and Corneal
Opacity in the Absence of Lumican . . . 1277
Keith K. H. Leung and
Ling Jim Ng and
Ken K. Y. Ho and
Patrick P. L. Tam and
Kathryn S. E. Cheah Different cis -Regulatory DNA Elements
Mediate Developmental Stage- and
Tissue-specific Expression of the Human
COL2A1 Gene in Transgenic Mice . . . . . 1291
Ciro Abbondanza and
Valentina Rossi and
Annarita Roscigno and
Luigi Gallo and
Angela Belsito and
Giulio Piluso and
Nicola Medici and
Vincenzo Nigro and
Anna Maria Molinari and
Bruno Moncharmont and
Giovanni A. Puca Interaction of Vault Particles with
Estrogen Receptor in the MCF-7 Breast
Cancer Cell . . . . . . . . . . . . . . 1301
Guillemette Huet and
Sylviane Hennebicq-Reig and
Carmen de Bolos and
Fausto Ulloa and
Thécla Lesuffleur and
Alain Barbat and
Véronique Carri\`ere and
Isabelle Kim and
Francisco X. Real and
Philippe Delannoy and
Alain Zweibaum GalNAc-$ \alpha $-O-benzyl Inhibits
NeuAc$ \alpha $2-3 Glycosylation and
Blocks the Intracellular Transport of
Apical Glycoproteins and Mucus in
Differentiated HT-29 Cells . . . . . . . 1311
Verena Karsten and
Huilin Qi and
Con J. M. Beckers and
Anita Reddy and
Jean-Francois Dubremetz and
Paul Webster and
Keith A. Joiner The Protozoan Parasite Toxoplasma gondii
Targets Proteins to Dense Granules and
the Vacuolar Space Using Both Conserved
and Unusual Mechanisms . . . . . . . . . 1323
Hui Qiao and
Sandra L. Pelletier and
Lucas Hoffman and
Jill Hacker and
R. Todd Armstrong and
Judith M. White Specific Single or Double Proline
Substitutions in the ``Spring-loaded''
Coiled--Coil Region of the Influenza
Hemagglutinin Impair or Abolish Membrane
Fusion Activity . . . . . . . . . . . . 1335
Michael B. Ferrari and
Katharina Ribbeck and
Donald J. Hagler and
Nicholas C. Spitzer A Calcium Signaling Cascade Essential
for Myosin Thick Filament Assembly in
\bionameXenopus Myocytes . . . . . . . . 1349
Blake L. Anderson and
Istvan Boldogh and
Marie Evangelista and
Charles Boone and
Lloyd A. Greene and
Liza A. Pon The Src Homology Domain 3 (SH3) of a
Yeast Type I Myosin, Myo5p, Binds to
Verprolin and Is Required for Targeting
to Sites of Actin Polarization . . . . . 1357
Istvan Boldogh and
Nikola Vojtov and
Sharon Karmon and
Liza A. Pon Interaction between Mitochondria and the
Actin Cytoskeleton in Budding Yeast
Requires Two Integral Mitochondrial
Outer Membrane Proteins, Mmm1p and
Mdm10p . . . . . . . . . . . . . . . . . 1371
Brigitte de Saint Phalle and
William Sullivan Spindle Assembly and Mitosis without
Centrosomes in Parthenogenetic Sciara
Embryos . . . . . . . . . . . . . . . . 1383
Marko Kallio and
Jasminder Weinstein and
John R. Daum and
Daniel J. Burke and
Gary J. Gorbsky Mammalian p55CDC Mediates Association of
the Spindle Checkpoint Protein Mad2 with
the Cyclosome/Anaphase-promoting
Complex, and is Involved in Regulating
Anaphase Onset and Late Mitotic Events 1393
Alfonso Dueñas Gonzalez and
Mitsunori Kaya and
Wen Shi and
Howard Song and
Joseph R. Testa and
Linda Z. Penn and
Jorge Filmus OCI-5\slash GPC3, a Glypican Encoded by
a Gene That Is Mutated in the
Simpson--Golabi--Behmel Overgrowth
Syndrome, Induces Apoptosis in a Cell
Line--specific Manner . . . . . . . . . 1407
Hans-Peter Hauser and
Michael Bardroff and
George Pyrowolakis and
Stefan Jentsch A Giant Ubiquitin-conjugating Enzyme
Related to IAP Apoptosis Inhibitors . . 1415
Shirlee Tan and
Yutaka Sagara and
Yuanbin Liu and
Pamela Maher and
David Schubert The Regulation of Reactive Oxygen
Species Production during Programmed
Cell Death . . . . . . . . . . . . . . . 1423
Inbal Simcha and
Michael Shtutman and
Daniela Salomon and
Jacob Zhurinsky and
Einat Sadot and
Benjamin Geiger and
Avri Ben-Ze'ev Differential Nuclear Translocation and
Transactivation Potential of $ \beta
$-Catenin and Plakoglobin . . . . . . . 1433
Enzo Calautti and
Sara Cabodi and
Paul L. Stein and
Mechthild Hatzfeld and
Nancy Kedersha and
G. Paolo Dotto Tyrosine Phosphorylation and Src Family
Kinases Control Keratinocyte Cell--Cell
Adhesion . . . . . . . . . . . . . . . . 1449
Gabriel Mbalaviele and
Riko Nishimura and
Akira Myoi and
Maria Niewolna and
Sakamuri V. Reddy and
Di Chen and
Jian Feng and
David Roodman and
Gregory R. Mundy and
Toshiyuki Yoneda Cadherin-6 Mediates the Heterotypic
Interactions between the Hemopoietic
Osteoclast Cell Lineage and Stromal
Cells in a Murine Model of Osteoclast
Differentiation . . . . . . . . . . . . 1467
Kuo-I Lin and
Joseph A. DiDonato and
Alexander Hoffmann and
J. Marie Hardwick and
Rajiv R. Ratan Suppression of Steady-state, but not
Stimulus-induced NF-$ \kappa $B Activity
Inhibits Alphavirus-induced Apoptosis 1479
Jesse C. Hay and
Judith Klumperman and
Viola Oorschot and
Martin Steegmaier and
Christin S. Kuo and
Richard H. Scheller Localization, Dynamics, and Protein
Interactions Reveal Distinct Roles for
ER and Golgi SNAREs . . . . . . . . . . 1489
Seng Hui Low and
Steven J. Chapin and
Christian Wimmer and
Sidney W. Whiteheart and
László G. Kömüves and
Keith E. Mostov and
Thomas Weimbs The SNARE Machinery Is Involved in
Apical Plasma Membrane Trafficking in
MDCK Cells . . . . . . . . . . . . . . . 1503
Ping Lin and
Helen Le-Niculescu and
Robert Hofmeister and
J. Michael McCaffery and
Mingjie Jin and
Hanjo Hennemann and
Tammie McQuistan and
Luc De Vries and
Marilyn Gist Farquhar The Mammalian Calcium-binding Protein,
Nucleobindin (CALNUC), Is a Golgi
Resident Protein . . . . . . . . . . . . 1515
Barbara Peracino and
Jane Borleis and
Tian Jin and
Monika Westphal and
Jean-Marc Schwartz and
Lijun Wu and
Enrico Bracco and
Günther Gerisch and
Peter Devreotes and
Salvatore Bozzaro G Protein $ \beta $ Subunit--null
Mutants Are Impaired in Phagocytosis and
Chemotaxis Due to Inappropriate
Regulation of the Actin Cytoskeleton . . 1529
Mikio Furuse and
Kohji Fujita and
Takashi Hiiragi and
Kazushi Fujimoto and
Shoichiro Tsukita Claudin-1 and -2: Novel Integral
Membrane Proteins Localizing at Tight
Junctions with No Sequence Similarity to
Occludin . . . . . . . . . . . . . . . . 1539
Shmuel Tuvia and
Shlomo Levin and
Arkady Bitler and
Rafi Korenstein Mechanical Fluctuations of the
Membrane--Skeleton Are Dependent on
F--Actin ATPase in Human Erythrocytes 1551
Andrew M. Fry and
Thibault Mayor and
Patrick Meraldi and
York-Dieter Stierhof and
Kayoko Tanaka and
Erich A. Nigg C-Nap1, a Novel Centrosomal Coiled--Coil
Protein and Candidate Substrate of the
Cell Cycle--regulated Protein Kinase
Nek2 . . . . . . . . . . . . . . . . . . 1563
L. Wu and
S. A. Osmani and
P. M. Mirabito A Role for NIMA in the Nuclear
Localization of Cyclin B in Aspergillus
nidulans . . . . . . . . . . . . . . . . 1575
Dennis R. LaJeunesse and
Brooke M. McCartney and
Richard G. Fehon Structural Analysis of
\bionameDrosophila Merlin Reveals
Functional Domains Important for Growth
Control and Subcellular Localization . . 1589
Ilham A. Muslimov and
Gary Banker and
Jürgen Brosius and
Henri Tiedge Activity-dependent Regulation of
Dendritic BC1 RNA in Hippocampal Neurons
in Culture . . . . . . . . . . . . . . . 1601
Zhengshan Dai and
H. Benjamin Peng A Role of Tyrosine Phosphatase in
Acetylcholine Receptor Cluster Dispersal
and Formation . . . . . . . . . . . . . 1613
Masaya Hirose and
Toshimasa Ishizaki and
Naoki Watanabe and
Masayoshi Uehata and
Onno Kranenburg and
Wouter H. Moolenaar and
Fumio Matsumura and
Midori Maekawa and
Haruhiko Bito and
Shuh Narumiya Molecular Dissection of the
Rho-associated Protein Kinase
(p160ROCK)-regulated Neurite Remodeling
in Neuroblastoma N1E-115 Cells . . . . . 1625
Michel Pucéat and
Serge Roche and
Guy Vassort Src Family Tyrosine Kinase Regulates
Intracellular pH in Cardiomyocytes . . . 1637
Theresa M. LaVallee and
Igor A. Prudovsky and
Grainne A. McMahon and
Xiaoguo Hu and
Thomas Maciag Activation of the MAP Kinase Pathway by
FGF-1 Correlates with Cell Proliferation
Induction While Activation of the Src
Pathway Correlates with Migration . . . 1647
Graziano Seghezzi and
Sundeep Patel and
Christine J. Ren and
Anna Gualandris and
Giuseppe Pintucci and
Edith S. Robbins and
Richard L. Shapiro and
Aubrey C. Galloway and
Daniel B. Rifkin and
Paolo Mignatti Fibroblast Growth Factor-2 (FGF-2)
Induces Vascular Endothelial Growth
Factor (VEGF) Expression in the
Endothelial Cells of Forming
Capillaries: an Autocrine Mechanism
Contributing to Angiogenesis . . . . . . 1659
Pauline O'Grady and
Tran Cam Thai and
Haruo Saito The Laminin--Nidogen Complex is a Ligand
for a Specific Splice Isoform of the
Transmembrane Protein Tyrosine
Phosphatase LAR . . . . . . . . . . . . 1675
Takaaki Hato and
Nisar Pampori and
Sanford J. Shattil Complementary Roles for Receptor
Clustering and Conformational Change in
the Adhesive and Signaling Functions of
Integrin $ \alpha_{IIb} $ $ \beta_3 $ 1685
Stephen S. Taylor and
Edward Ha and
Frank McKeon The Human Homologue of Bub3 Is Required
for Kinetochore Localization of Bub1 and
a Mad3/Bub1-related Protein Kinase . . . 1
Christine Moulton Clemson and
Jennifer C. Chow and
Carolyn J. Brown and
Jeanne Bentley Lawrence Stabilization and Localization of Xist
RNA are Controlled by Separate
Mechanisms and are Not Sufficient for X
Inactivation . . . . . . . . . . . . . . 13
Jan Willem Kok and
Teresa Babia and
Catalin M. Filipeanu and
Adriaan Nelemans and
Gustavo Egea and
Dick Hoekstra PDMP Blocks Brefeldin A--induced
Retrograde Membrane Transport from Golgi
to ER: Evidence for Involvement of
Calcium Homeostasis and Dissociation
from Sphingolipid Metabolism . . . . . . 25
Laurie A. Graham and
Kathryn J. Hill and
Tom H. Stevens Assembly of the Yeast Vacuolar
H$^+$-ATPase Occurs in the Endoplasmic
Reticulum and Requires a Vma12p/Vma22p
Assembly Complex . . . . . . . . . . . . 39
Sasa Lin and
Hussein Y. Naim and
A. Chapin Rodriguez and
Michael G. Roth Mutations in the Middle of the
Transmembrane Domain Reverse the
Polarity of Transport of the Influenza
Virus Hemagglutinin in MDCK Epithelial
Cells . . . . . . . . . . . . . . . . . 51
Richard G. Kibbey and
Josep Rizo and
Lila M. Gierasch and
Richard G. W. Anderson The LDL Receptor Clustering Motif
Interacts with the Clathrin Terminal
Domain in a Reverse Turn Conformation 59
A. K. Kenworthy and
M. Edidin Distribution of a
glycosylphosphatidylinositol-anchored
protein at the apical surface of MDCK
cells examined at a resolution of $< 100$Å
using imaging fluorescence resonance
energy transfer . . . . . . . . . . . . 69
Tzuu-Shuh Jou and
W. James Nelson Effects of Regulated Expression of
Mutant RhoA and Rac1 Small GTPases on
the Development of Epithelial (MDCK)
Cell Polarity . . . . . . . . . . . . . 85
Tzuu-Shuh Jou and
Eveline E. Schneeberger and
W. James Nelson Structural and Functional Regulation of
Tight Junctions by RhoA and Rac1 Small
GTPases . . . . . . . . . . . . . . . . 101
Inés Mart\`\in-Padura and
Susan Lostaglio and
Markus Schneemann and
Lisa Williams and
Maria Romano and
Paolo Fruscella and
Carla Panzeri and
Antonella Stoppacciaro and
Luigi Ruco and
Antonello Villa and
David Simmons and
Elisabetta Dejana Junctional Adhesion Molecule, a Novel
Member of the Immunoglobulin Superfamily
That Distributes at Intercellular
Junctions and Modulates Monocyte
Transmigration . . . . . . . . . . . . . 117
Alexandra R. Cohen and
Daniel F. Wood and
Shirin M. Marfatia and
Zenta Walther and
Athar H. Chishti and
James Melvin Anderson Human CASK/LIN-2 Binds Syndecan-2 and
Protein 4.1 and Localizes to the
Basolateral Membrane of Epithelial Cells 129
Yi-Ping Hsueh and
Fu-Chia Yang and
Viktor Kharazia and
Scott Naisbitt and
Alexandra R. Cohen and
Richard J. Weinberg and
Morgan Sheng Direct Interaction of CASK/LIN-2 and
Syndecan Heparan Sulfate Proteoglycan
and Their Overlapping Distribution in
Neuronal Synapses . . . . . . . . . . . 139
C. Poüs and
K. Chabin and
A. Drechou and
L. Barbot and
T. Phung-Koskas and
C. Settegrana and
M. L. Bourguet-Kondracki and
M. Maurice and
D. Cassio and
M. Guyot and
G. Durand Functional Specialization of Stable and
Dynamic Microtubules in Protein Traffic
in WIF--B Cells . . . . . . . . . . . . 153
Laurent Guillaud and
Christophe Bosc and
Anne Fourest-Lieuvin and
Eric Denarier and
Fabienne Pirollet and
Laurence Lafanech\`ere and
Didier Job STOP Proteins are Responsible for the
High Degree of Microtubule Stabilization
Observed in Neuronal Cells . . . . . . . 167
Irina Kaverina and
Klemens Rottner and
J. Victor Small Targeting, Capture, and Stabilization of
Microtubules at Early Focal Adhesions 181
A. Shibata and
M. V. Wright and
S. David and
L. McKerracher and
P. E. Braun and
S. B. Kater Unique Responses of Differentiating
Neuronal Growth Cones to Inhibitory Cues
Presented by Oligodendrocytes . . . . . 191
Nobuaki Maeda and
Masaharu Noda Involvement of Receptor-like Protein
Tyrosine Phosphatase $ \zeta $ /RPTP$
\beta $ and Its Ligand
Pleiotrophin/Heparin-binding
Growth-associated Molecule (HB-GAM) in
Neuronal Migration . . . . . . . . . . . 203
Di Lu and
Hong Yang and
Robert H. Lenox and
Mohan K. Raizada Regulation of Angiotensin II--induced
Neuromodulation by MARCKS in Brain
Neurons . . . . . . . . . . . . . . . . 217
James R. Van Brocklyn and
Menq-Jer Lee and
Ramil Menzeleev and
Ana Olivera and
Lisa Edsall and
Olivier Cuvillier and
Dianne M. Thomas and
Peter J. P. Coopman and
Shobha Thangada and
Catherine H. Liu and
Timothy Hla and
Sarah Spiegel Dual Actions of Sphingosine-1-Phosphate:
Extracellular through the G$_i$-coupled
Receptor Edg-1 and Intracellular to
Regulate Proliferation and Survival . . 229
Arthur J. Kudla and
Nathan C. Jones and
R. Scott Rosenthal and
Kirstin Arthur and
Kari L. Clase and
Bradley B. Olwin The FGF Receptor--1 Tyrosine Kinase
Domain Regulates Myogenesis but Is Not
Sufficient to Stimulate Proliferation 241
Michael Hortsch and
Diahann Homer and
Jyoti Dhar Malhotra and
Sherry Chang and
Jason Frankel and
Gregory Jefford and
Ronald R. Dubreuil Structural Requirements for Outside--In
and Inside--Out Signaling by
\bionameDrosophila Neuroglian, a Member
of the L1 Family of Cell Adhesion
Molecules . . . . . . . . . . . . . . . 251
Karen R. Snapp and
Ron Craig and
Michael Herron and
Robert D. Nelson and
Lloyd M. Stoolman and
Geoffrey S. Kansas Dimerization of P--Selectin Glycoprotein
Ligand-1 (PSGL-1) Required for Optimal
Recognition of P--Selectin . . . . . . . 263
Roel Q. J. Schaapveld and
Luca Borradori and
Dirk Geerts and
Manuel R. van Leusden and
Ingrid Kuikman and
Mirjam G. Nievers and
Carien M. Niessen and
Renske D. M. Steenbergen and
Peter J. F. Snijders and
Arnoud Sonnenberg Hemidesmosome Formation Is Initiated by
the $ \beta $4 Integrin Subunit,
Requires Complex Formation of $ \beta $4
and HD1/Plectin, and Involves a Direct
Interaction between $ \beta $4 and the
Bullous Pemphigoid Antigen 180 . . . . . 271
Rupert Hagg and
Peter Bruckner and
Erik Hedbom Cartilage Fibrils of Mammals are
Biochemically Heterogeneous:
Differential Distribution of Decorin and
Collagen IX . . . . . . . . . . . . . . 285
D. Chen and
X. Ji and
M. A. Harris and
J. Q. Feng and
G. Karsenty and
A. J. Celeste and
V. Rosen and
G. R. Mundy and
S. E. Harris Differential Roles for Bone
Morphogenetic Protein (BMP) Receptor
Type IB and IA in Differentiation and
Specification of Mesenchymal Precursor
Cells to Osteoblast and Adipocyte
Lineages . . . . . . . . . . . . . . . . 295
Da Wei Huang and
Laura Fanti and
Daniel T. S. Pak and
Michael R. Botchan and
Sergio Pimpinelli and
Rebecca Kellum Distinct Cytoplasmic and Nuclear
Fractions of \bionameDrosophila
Heterochromatin Protein 1: Their
Phosphorylation Levels and Associations
with Origin Recognition Complex Proteins 307
Cynthia Isaac and
Yunfeng Yang and
U. Thomas Meier Nopp140 Functions as a Molecular Link
Between the Nucleolus and the Coiled
Bodies . . . . . . . . . . . . . . . . . 319
Li Yuan and
Jeanette Pelttari and
Eva Brundell and
Birgitta Björkroth and
Jian Zhao and
Jian-Guo Liu and
Hjalmar Brismar and
Bertil Daneholt and
Christer Höög The Synaptonemal Complex Protein SCP3
Can Form Multistranded, Cross-striated
Fibers In Vivo . . . . . . . . . . . . . 331
Stephen C. Ogg and
Wolfgang P. Barz and
Peter Walter A Functional GTPase Domain, but not its
Transmembrane Domain, is Required for
Function of the SRP Receptor $ \beta
$-subunit . . . . . . . . . . . . . . . 341
Walther Mothes and
Berit Jungnickel and
Josef Brunner and
Tom A. Rapoport Signal Sequence Recognition in
Cotranslational Translocation by Protein
Components of the Endoplasmic Reticulum
Membrane . . . . . . . . . . . . . . . . 355
Domenico Tortorella and
Craig M. Story and
Johannes B. Huppa and
Emmanuel J. H. J. Wiertz and
Thomas R. Jones and
Hidde L. Ploegh Dislocation of Type I Membrane Proteins
from the ER to the Cytosol Is Sensitive
to Changes in Redox Potential . . . . . 365
Florence Vollenweider and
Felix Kappeler and
Christian Itin and
Hans-Peter Hauri Mistargeting of the Lectin ERGIC-53 to
the Endoplasmic Reticulum of HeLa Cells
Impairs the Secretion of a Lysosomal
Enzyme . . . . . . . . . . . . . . . . . 377
Chean Eng Ooi and
Esteban C. Dell'Angelica and
Juan S. Bonifacino ADP-Ribosylation Factor 1 (ARF1)
Regulates Recruitment of the AP-3
Adaptor Complex to Membranes . . . . . . 391
Vladimir I. Titorenko and
Jennifer J. Smith and
Rachel K. Szilard and
Richard A. Rachubinski Pex20p of the Yeast Yarrowia lipolytica
Is Required for the Oligomerization of
Thiolase in the Cytosol and for Its
Targeting to the Peroxisome . . . . . . 403
Ewald H. Hettema and
Caroline C. M. Ruigrok and
Marian Groot Koerkamp and
Marlene van den Berg and
Henk F. Tabak and
Ben Distel and
Ineke Braakman The Cytosolic DnaJ-like Protein Djp1p Is
Involved Specifically in Peroxisomal
Protein Import . . . . . . . . . . . . . 421
Christopher B. Yohn and
Amybeth Cohen and
Cristen Rosch and
Michael R. Kuchka and
Stephen P. Mayfield Translation of the Chloroplast psbA mRNA
Requires the Nuclear-encoded
Poly(A)-binding Protein, RB47 . . . . . 435
Mahasin A. Osman and
Richard A. Cerione Iqg1p, a Yeast Homologue of the
Mammalian IQGAPs, Mediates Cdc42p
Effects on the Actin Cytoskeleton . . . 443
Kenneth E. Sawin and
Paul Nurse Regulation of Cell Polarity by
Microtubules in Fission Yeast . . . . . 457
Burkhard Wiesner and
Jocelyn Weiner and
Ralf Middendorff and
Volker Hagen and
U. Benjamin Kaupp and
Ingo Weyand Cyclic Nucleotide-gated Channels on the
Flagellum Control Ca$^{2+}$ Entry into
Sperm . . . . . . . . . . . . . . . . . 473
Yoichiro Matsuoka and
Xiaolin Li and
Vann Bennett Adducin Is an In Vivo Substrate for
Protein Kinase C: Phosphorylation in the
MARCKS-related Domain Inhibits Activity
in Promoting Spectrin--Actin Complexes
and Occurs in Many Cells, Including
Dendritic Spines of Neurons . . . . . . 485
Susannetom Dieck and
Lydia Sanmartí-Vila and
Kristina Langnaese and
Karin Richter and
Stefan Kindler and
Antje Soyke and
Heike Wex and
Karl-Heinz Smalla and
Udo Kämpf and
Jürgen-Theodor Fränzer and
Markus Stumm and
Craig C. Garner and
Eckart D. Gundelfinger Bassoon, a Novel Zinc-finger
CAG/Glutamine-repeat Protein Selectively
Localized at the Active Zone of
Presynaptic Nerve Terminals . . . . . . 499
Jiacheng Yang and
Judith A. Drazba and
Donald G. Ferguson and
Meredith Bond A-kinase Anchoring Protein 100 (AKAP100)
is Localized in Multiple Subcellular
Compartments in the Adult Rat Heart . . 511
Angela Clerk and
Ashour Michael and
Peter H. Sugden Stimulation of the p38 Mitogen-activated
Protein Kinase Pathway in Neonatal Rat
Ventricular Myocytes by the G
Protein--coupled Receptor Agonists,
Endothelin-1 and Phenylephrine: a Role
in Cardiac Myocyte Hypertrophy? . . . . 523
Janice A. Dominov and
Jonathan J. Dunn and
Jeffrey Boone Miller Bcl-2 Expression Identifies an Early
Stage of Myogenesis and Promotes Clonal
Expansion of Muscle Cells . . . . . . . 537
Xian-Zhong Shawn Xu and
Atish Choudhury and
Xiaoling Li and
Craig Montell Coordination of an Array of Signaling
Proteins through Homo- and Heteromeric
Interactions Between PDZ Domains and
Target Proteins . . . . . . . . . . . . 545
Brad St. Croix and
Capucine Sheehan and
Janusz W. Rak and
Vivi Ann Flòrenes and
Joyce M. Slingerland and
Robert S. Kerbel E-Cadherin-dependent Growth Suppression
is Mediated by the Cyclin-dependent
Kinase Inhibitor p27$^{\rm KIP1}$ . . . 557
Edwin A. Clark and
Warren G. King and
Joan S. Brugge and
Marc Symons and
Richard O. Hynes Integrin-mediated Signals Regulated by
Members of the Rho Family of GTPases . . 573
Ambra Pozzi and
Kishore K. Wary and
Filippo G. Giancotti and
Humphrey A. Gardner Integrin $ \alpha $1$ \beta $1 Mediates
a Unique Collagen-dependent
Proliferation Pathway In Vivo . . . . . 587
Dheepika Weerasinghe and
Kevin P. McHugh and
Frederick P. Ross and
Eric J. Brown and
Roland H. Gisler and
Beat A. Imhof A Role for the $ \alpha $ v$ \beta $3
Integrin in the Transmigration of
Monocytes . . . . . . . . . . . . . . . 595
Fern P. Finger and
Peter Novick Spatial Regulation of Exocytosis:
Lessons from Yeast . . . . . . . . . . . 609
Koji Okamoto and
Philip S. Perlman and
Ronald A. Butow The Sorting of Mitochondrial DNA and
Mitochondrial Proteins in Zygotes:
Preferential Transmission of
Mitochondrial DNA to the Medial Bud . . 613
Philippe Lenormand and
Jean-Marc Brondello and
Anne Brunet and
Jacques Pouysségur Growth Factor--induced p42/p44 MAPK
Nuclear Translocation and Retention
Requires Both MAPK Activation and
Neosynthesis of Nuclear Anchoring
Proteins . . . . . . . . . . . . . . . . 625
Amy Tam and
Franklin J. Nouvet and
Konomi Fujimura-Kamada and
Hilda Slunt and
Sangram S. Sisodia and
Susan Michaelis Dual Roles for Ste24p in Yeast a--Factor
Maturation: NH$_2$-terminal Proteolysis
and COOH-terminal CAAX Processing . . . 635
Nia J. Bryant and
Robert C. Piper and
Lois S. Weisman and
Tom H. Stevens Retrograde Traffic Out of the Yeast
Vacuole to the TGN Occurs via the
Prevacuolar/Endosomal Compartment . . . 651
Matthew N. J. Seaman and
J. Michael McCaffery and
Scott D. Emr A Membrane Coat Complex Essential for
Endosome-to-Golgi Retrograde Transport
in Yeast . . . . . . . . . . . . . . . . 665
Sven C. D. van IJzendoorn and
Dick Hoekstra (Glyco)sphingolipids Are Sorted in
Sub--Apical Compartments in HepG2 Cells:
a Role for Non--Golgi-Related
Intracellular Sites in the Polarized
Distribution of (Glyco)sphingolipids . . 683
Alan D. Marmorstein and
Yunbo C. Gan and
Vera L. Bonilha and
Silvia C. Finnemann and
Karl G. Csaky and
Enrique Rodriguez-Boulan Apical Polarity of N-CAM and EMMPRIN in
Retinal Pigment Epithelium Resulting
from Suppression of Basolateral Signal
Recognition . . . . . . . . . . . . . . 697
Richard C. Stevens and
Trisha N. Davis Mlc1p Is a Light Chain for the
Unconventional Myosin Myo2p in
\bionameSaccharomyces cerevisiae . . . . 711
Bruce L. Goode and
David G. Drubin and
Pekka Lappalainen Regulation of the Cortical Actin
Cytoskeleton in Budding Yeast by
Twinfilin, a Ubiquitous Actin
Monomer-sequestering Protein . . . . . . 723
Francisco Rivero and
Adam Kuspa and
Regine Brokamp and
Monika Matzner and
Angelika A. Noegel Interaptin, an Actin-binding Protein of
the $ \alpha $-Actinin Superfamily in
\bionameDictyostelium discoideum, Is
Developmentally and cAMP-regulated and
Associates with Intracellular Membrane
Compartments . . . . . . . . . . . . . . 735
Silvia Bonaccorsi and
Maria Grazia Giansanti and
Maurizio Gatti Spindle Self-organization and
Cytokinesis During Male Meiosis in
asterless Mutants of \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 751
Daniel A. Starr and
Byron C. Williams and
Thomas S. Hays and
Michael L. Goldberg ZW10 Helps Recruit Dynactin and Dynein
to the Kinetochore . . . . . . . . . . . 763
Michelle Moritz and
Yixian Zheng and
Bruce M. Alberts and
Karen Oegema Recruitment of the $ \gamma $-Tubulin
Ring Complex to \bionameDrosophila
Salt-stripped Centrosome Scaffolds . . . 775
Todd Maney and
Andrew W. Hunter and
Mike Wagenbach and
Linda Wordeman Mitotic Centromere--associated Kinesin
Is Important for Anaphase Chromosome
Segregation . . . . . . . . . . . . . . 787
Amy R. Reilein and
Irina S. Tint and
Natalia I. Peunova and
Grigori N. Enikolopov and
Vladimir I. Gelfand Regulation of Organelle Movement in
Melanophores by Protein Kinase A (PKA),
Protein Kinase C (PKC), and Protein
Phosphatase 2A (PP2A) . . . . . . . . . 803
Chiara Albertinazzi and
Daniela Gilardelli and
Simona Paris and
Renato Longhi and
Ivan de Curtis Overexpression of a Neural-specific Rho
Family GTPase, cRac1B, Selectively
Induces Enhanced Neuritogenesis and
Neurite Branching in Primary Neurons . . 815
Corine Bertolotto and
Patricia Abbe and
Timothy J. Hemesath and
Karine Bille and
David E. Fisher and
Jean-Paul Ortonne and
Robert Ballotti Microphthalmia Gene Product as a Signal
Transducer in cAMP--Induced
Differentiation of Melanocytes . . . . . 827
Nikolai A. Chitaev and
Sergey M. Troyanovsky Adhesive But Not Lateral E-cadherin
Complexes Require Calcium and Catenins
for Their Formation . . . . . . . . . . 837
Mitsuko Watabe-Uchida and
Naoshige Uchida and
Yuzo Imamura and
Akira Nagafuchi and
Kazushi Fujimoto and
Tadashi Uemura and
Stefan Vermeulen and
Frans van Roy and
Eileen D. Adamson and
Masatoshi Takeichi $ \alpha $-Catenin-Vinculin Interaction
Functions to Organize the Apical
Junctional Complex in Epithelial Cells 847
Hendra Setiadi and
Gerald Sedgewick and
Stanley L. Erlandsen and
Rodger P. McEver Interactions of the Cytoplasmic Domain
of P--Selectin with Clathrin-coated Pits
Enhance Leukocyte Adhesion under Flow 859
Guido Serini and
Marie-Luce Bochaton-Piallat and
Patricia Ropraz and
Antoine Geinoz and
Laura Borsi and
Luciano Zardi and
Giulio Gabbiani The Fibronectin Domain ED--A Is Crucial
for Myofibroblastic Phenotype Induction
by Transforming Growth Factor-$ \beta $1 873
Andrew J. Saurin and
Carol Shiels and
Jill Williamson and
David P. E. Satijn and
Arie P. Otte and
Denise Sheer and
Paul S. Freemont The Human Polycomb Group Complex
Associates with Pericentromeric
Heterochromatin to Form a Novel Nuclear
Domain . . . . . . . . . . . . . . . . . 887
Fátima Almeida and
Rainer Saffrich and
Wilhelm Ansorge and
Maria Carmo-Fonseca Microinjection of Anti-coilin Antibodies
Affects the Structure of Coiled Bodies 899
Tamara Darsow and
Christopher G. Burd and
Scott D. Emr Acidic Di-leucine Motif Essential for
AP-3-dependent Sorting and Restriction
of the Functional Specificity of the
Vam3p Vacuolar t-SNARE . . . . . . . . . 913
Richik N. Ghosh and
William G. Mallet and
Thwe T. Soe and
Timothy E. McGraw and
Frederick R. Maxfield An Endocytosed TGN38 Chimeric Protein Is
Delivered to the TGN after Trafficking
through the Endocytic Recycling
Compartment in CHO Cells . . . . . . . . 923
Adeela Kamal and
Yun-shu Ying and
Richard G. W. Anderson Annexin VI-mediated Loss of Spectrin
during Coated Pit Budding Is Coupled to
Delivery of LDL to Lysosomes . . . . . . 937
Amy F. Roth and
Daniel M. Sullivan and
Nicholas G. Davis A Large PEST-like Sequence Directs the
Ubiquitination, Endocytosis, and
Vacuolar Degradation of the Yeast
a--Factor Receptor . . . . . . . . . . . 949
Linu M. John and
James D. Lechleiter and
Patricia Camacho Differential Modulation of SERCA2
Isoforms by Calreticulin . . . . . . . . 963
Michael R. Duchen and
Anne Leyssens and
Martin Crompton Transient Mitochondrial Depolarizations
Reflect Focal Sarcoplasmic Reticular
Calcium Release in Single Rat
Cardiomyocytes . . . . . . . . . . . . . 975
Michio Tomishige and
Yasushi Sako and
Akihiro Kusumi Regulation Mechanism of the Lateral
Diffusion of Band 3 in Erythrocyte
Membranes by the Membrane Skeleton . . . 989
Sally H. Zigmond and
Michael Joyce and
Changsong Yang and
Kevin Brown and
Minzhou Huang and
Martin Pring Mechanism of Cdc42-induced Actin
Polymerization in Neutrophil Extracts 1001
Conly L. Rieder and
Richard W. Cole Entry into Mitosis in Vertebrate Somatic
Cells Is Guarded by a Chromosome Damage
Checkpoint That Reverses the Cell Cycle
When Triggered during Early but Not Late
Prophase . . . . . . . . . . . . . . . . 1013
Sher Karki and
Bernadette LaMonte and
Erika L. F. Holzbaur Characterization of the p22 Subunit of
Dynactin Reveals the Localization of
Cytoplasmic Dynein and Dynactin to the
Midbody of Dividing Cells . . . . . . . 1023
Rudolph D. Paladini and
Pierre A. Coulombe Directed Expression of Keratin 16 to the
Progenitor Basal Cells of Transgenic
Mouse Skin Delays Skin Maturation . . . 1035
Shinichiro Taya and
Takaharu Yamamoto and
Kyoko Kano and
Yoji Kawano and
Akihiro Iwamatsu and
Tomoko Tsuchiya and
Keiji Tanaka and
Masami Kanai-Azuma and
Stephen A. Wood and
John S. Mattick and
Kozo Kaibuchi The Ras Target AF-6 is a Substrate of
the Fam Deubiquitinating Enzyme . . . . 1053
Claudio Sette and
Arturo Bevilacqua and
Raffaele Geremia and
Pellegrino Rossi Involvement of Phospholipase C$ \gamma
$1 in Mouse Egg Activation Induced by a
Truncated Form of the C-kit Tyrosine
Kinase Present in Spermatozoa . . . . . 1063
Zhican Qu and
Lawrence A. Wolfraim and
John Svaren and
Markus U. Ehrengruber and
Norman Davidson and
Jeffrey Milbrandt The Transcriptional Corepressor NAB2
Inhibits NGF-induced Differentiation of
PC12 Cells . . . . . . . . . . . . . . . 1075
Hansjürgen Volkmer and
Ute Zacharias and
Ursel Nörenberg and
Fritz G. Rathjen Dissection of Complex Molecular
Interactions of Neurofascin with
Axonin-1, F11, and Tenascin--R, Which
Promote Attachment and Neurite Formation
of Tectal Cells . . . . . . . . . . . . 1083
Rita J. Balice-Gordon and
Linda J. Bone and
Steven S. Scherer Functional Gap Junctions in the Schwann
Cell Myelin Sheath . . . . . . . . . . . 1095
Cynthia L. Adams and
Yih-Tai Chen and
Stephen J. Smith and
W. James Nelson Mechanisms of Epithelial Cell--Cell
Adhesion and Cell Compaction Revealed by
High-resolution Tracking of
E-Cadherin/Green Fluorescent Protein . . 1105
Helen Priddle and
Lance Hemmings and
Susan Monkley and
Alison Woods and
Bipin Patel and
Deborah Sutton and
Graham A. Dunn and
Daniel Zicha and
David R. Critchley Disruption of the Talin Gene Compromises
Focal Adhesion Assembly in
Undifferentiated but Not Differentiated
Embryonic Stem Cells . . . . . . . . . . 1121
Maria Nurminskaya and
Cordula Magee and
Dmitry Nurminsky and
Thomas F. Linsenmayer Plasma Transglutaminase in Hypertrophic
Chondrocytes: Expression and
Cell-specific Intracellular Activation
Produce Cell Death and Externalization 1135
Livio Trusolino and
Guido Serini and
Germana Cecchini and
Cristina Besati and
Francesco Saverio Ambesi-Impiombato and
Pier Carlo Marchisio and
Rosaria De Filippi Growth Factor-dependent Activation of $
\alpha v \beta 3 $ Integrin in Normal
Epithelial Cells: Implications for Tumor
Invasion . . . . . . . . . . . . . . . . 1145
Jean-Marc Lemaitre and
Gérard Géraud and
Marcel Méchali Dynamics of the Genome during Early
\bionameXenopus laevis Development:
Karyomeres As Independent Units of
Replication . . . . . . . . . . . . . . 1159
Céline Verheggen and
Sophie Le Panse and
Genevi\`eve Almouzni and
Dani\`ele Hernandez-Verdun Presence of Pre-rRNAs before Activation
of Polymerase I Transcription in the
Building Process of Nucleoli during
Early Development of \bionameXenopus
laevis . . . . . . . . . . . . . . . . . 1167
Xin Sun and
Alla T. Alzhanova-Ericsson and
Neus Visa and
Youssef Aissouni and
Jian Zhao and
Bertil Daneholt The hrp23 Protein in the Balbiani Ring
Pre-mRNP Particles Is Released Just
before or at the Binding of the
Particles to the Nuclear Pore Complex 1181
Silvia Gigliotti and
Giuliano Callaini and
Silvia Andone and
Maria Giovanna Riparbelli and
Roberto Pernas-Alonso and
Gyula Hoffmann and
Franco Graziani and
Carla Malva Nup154, a New \bionameDrosophila Gene
Essential for Male and Female
Gametogenesis Is Related to the Nup155
Vertebrate Nucleoporin Gene . . . . . . 1195
Jacqueline Powers and
Charles Barlowe Transport of Axl2p Depends on Erv14p, an
ER--Vesicle Protein Related to the
\bionameDrosophila cornichon Gene
Product . . . . . . . . . . . . . . . . 1209
Claude A. Jakob and
Patricie Burda and
Jürgen Roth and
Markus Aebi Degradation of Misfolded Endoplasmic
Reticulum Glycoproteins in
\bionameSaccharomyces cerevisiae Is
Determined by a Specific Oligosaccharide
Structure . . . . . . . . . . . . . . . 1223
Barbara Landolfi and
Silvana Curci and
Lucantonio Debellis and
Tullio Pozzan and
Aldebaran M. Hofer Ca$^{2+}$ Homeostasis in the
Agonist-sensitive Internal Store:
Functional Interactions Between
Mitochondria and the ER Measured In Situ
in Intact Cells . . . . . . . . . . . . 1235
Jen-Zen Chuang and
Ching-Hwa Sung The Cytoplasmic Tail of Rhodopsin Acts
as a Novel Apical Sorting Signal in
Polarized MDCK Cells . . . . . . . . . . 1245
Zhuqing Qu and
Levent Balkir and
Judith C. T. van Deutekom and
Paul D. Robbins and
Ryan Pruchnic and
Johnny Huard Development of Approaches to Improve
Cell Survival in Myoblast Transfer
Therapy . . . . . . . . . . . . . . . . 1257
Matthew F. Peters and
Hél\`ene M. Sadoulet-Puccio and
R. Mark Grady and
Neal R. Kramarcy and
Louis M. Kunkel and
Joshua R. Sanes and
Robert Sealock and
Stanley C. Froehner Differential Membrane Localization and
Intermolecular Associations of $ \alpha
$-Dystrobrevin Isoforms in Skeletal
Muscle . . . . . . . . . . . . . . . . . 1269
Andrew A. Hack and
Chantal T. Ly and
Fang Jiang and
Cynthia J. Clendenin and
Kirsten S. Sigrist and
Robert L. Wollmann and
Elizabeth M. McNally $ \gamma $-Sarcoglycan Deficiency Leads
to Muscle Membrane Defects and Apoptosis
Independent of Dystrophin . . . . . . . 1279
Lisa D. Belmont and
David G. Drubin The Yeast V159N Actin Mutant Reveals
Roles for Actin Dynamics In Vivo . . . . 1289
Erfei Bi and
Paul Maddox and
Daniel J. Lew and
E. D. Salmon and
John N. McMillan and
Elaine Yeh and
John R. Pringle Involvement of an Actomyosin Contractile
Ring in \bionameSaccharomyces cerevisiae
Cytokinesis . . . . . . . . . . . . . . 1301
James L. Franklin and
Eugene M. Johnson Control of Neuronal Size Homeostasis by
Trophic Factor--mediated Coupling of
Protein Degradation to Protein Synthesis 1313
James E. Bear and
John F. Rawls and
Charles L. Saxe SCAR, a WASP-related Protein, Isolated
as a Suppressor of Receptor Defects in
Late \bionameDictyostelium Development 1325
Ming-Jer Tang and
Dane Worley and
Michele Sanicola and
Gregory R. Dressler The RET--Glial Cell-derived Neurotrophic
Factor (GDNF) Pathway Stimulates
Migration and Chemoattraction of
Epithelial Cells . . . . . . . . . . . . 1337
Olugbenga A. Adebanjo and
Baljit S. Moonga and
Tomoo Yamate and
Li Sun and
Cedric Minkin and
Etsuko Abe and
Mone Zaidi Mode of Action of Interleukin-6 on
Mature Osteoclasts. Novel Interactions
with Extracellular Ca$^{2+}$ Sensing in
the Regulation of Osteoclastic Bone
Resorption . . . . . . . . . . . . . . . 1347
Kairbaan M. Hodivala-Dilke and
C. Michael DiPersio and
Jordan A. Kreidberg and
Richard O. Hynes Novel Roles for $ \alpha $3$ \beta $1
Integrin as a Regulator of Cytoskeletal
Assembly and as a Trans-dominant
Inhibitor of Integrin Receptor Function
in Mouse Keratinocytes . . . . . . . . . 1357
Ron D. M. Soede and
Yvonne M. Wijnands and
Ioana Van Kouteren-Cobzaru and
Ed Roos ZAP-70 Tyrosine Kinase Is Required for
LFA-1-dependent T Cell Migration . . . . 1371
P. Lorenzon and
E. Vecile and
E. Nardon and
E. Ferrero and
J. M. Harlan and
F. Tedesco and
A. Dobrina Endothelial Cell E- and P--Selectin and
Vascular Cell Adhesion Molecule-1
Function as Signaling Receptors . . . . 1381
Jacopo Meldolesi and
Tullio Pozzan The Heterogeneity of ER Ca$^{2+}$ Stores
Has a Key Role in Nonmuscle Cell
Signaling and Function . . . . . . . . . 1395
Sean S. Molloy and
Laurel Thomas and
Craig Kamibayashi and
Marc C. Mumby and
Gary Thomas Regulation of Endosome Sorting by a
Specific PP2A Isoform . . . . . . . . . 1399
Frank Lafont and
Sandra Lecat and
Paul Verkade and
Kai Simons Annexin XIIIb Associates with Lipid
Microdomains to Function in Apical
Delivery . . . . . . . . . . . . . . . . 1413
Thorkil Ploug and
Bo van Deurs and
Hua Ai and
Samuel W. Cushman and
Evelyn Ralston Analysis of GLUT4 Distribution in Whole
Skeletal Muscle Fibers: Identification
of Distinct Storage Compartments That
Are Recruited by Insulin and Muscle
Contractions . . . . . . . . . . . . . . 1429
Magali Kitzmann and
Gilles Carnac and
Marie Vandromme and
Michael Primig and
Ned J. C. Lamb and
Anne Fernandez The Muscle Regulatory Factors MyoD and
Myf-5 Undergo Distinct Cell
Cycle--specific Expression in Muscle
Cells . . . . . . . . . . . . . . . . . 1447
Franck Duclos and
Volker Straub and
Steven A. Moore and
David P. Venzke and
Ron F. Hrstka and
Rachelle H. Crosbie and
Madeleine Durbeej and
Connie S. Lebakken and
Audrey J. Ettinger and
Jack van der Meulen and
Kathleen H. Holt and
Leland E. Lim and
Joshua R. Sanes and
Beverly L. Davidson and
John A. Faulkner and
Roger Williamson and
Kevin P. Campbell Progressive Muscular Dystrophy in $
\alpha $-Sarcoglycan--deficient Mice . . 1461
Lisa Elia and
Lorraine Marsh A Role for a Protease in Morphogenic
Responses during Yeast Cell Fusion . . . 1473
John N. McMillan and
Rey A. L. Sia and
Daniel J. Lew A Morphogenesis Checkpoint Monitors the
Actin Cytoskeleton in Yeast . . . . . . 1487
Tatiana S. Karpova and
James G. McNally and
Samuel L. Moltz and
John A. Cooper Assembly and Function of the Actin
Cytoskeleton of Yeast: Relationships
between Cables and Patches . . . . . . . 1501
Yasmina Saoudi and
Rati Fotedar and
Ariane Abrieu and
Marcel Dorée and
Jürgen Wehland and
Robert L. Margolis and
Didier Job Stepwise Reconstitution of Interphase
Microtubule Dynamics in Permeabilized
Cells and Comparison to Dynamic
Mechanisms in Intact Cells . . . . . . . 1519
Paul S. Shapiro and
Eugeni Vaisberg and
Alan J. Hunt and
Nicholas S. Tolwinski and
Anne M. Whalen and
J. Richard McIntosh and
Natalie G. Ahn Activation of the MKK/ERK Pathway during
Somatic Cell Mitosis: Direct
Interactions of Active ERK with
Kinetochores and Regulation of the
Mitotic 3F3/2 Phosphoantigen . . . . . . 1533
Maja Zecevic and
Andrew D. Catling and
Scott T. Eblen and
Luigina Renzi and
James C. Hittle and
Tim J. Yen and
Gary J. Gorbsky and
Michael J. Weber Active MAP Kinase in Mitosis:
Localization at Kinetochores and
Association with the Motor Protein
CENP--E . . . . . . . . . . . . . . . . 1547
Akiko Kumagai and
Zijian Guo and
Katayoon H. Emami and
Sophie X. Wang and
William G. Dunphy The \bionameXenopus Chk1 Protein Kinase
Mediates a Caffeine-sensitive Pathway of
Checkpoint Control in Cell-free Extracts 1559
Xu Zhang and
Vann Bennett Restriction of 480/270-kD Ankyrin$_G$ to
Axon Proximal Segments Requires Multiple
Ankyrin$_G$-specific Domains . . . . . . 1571
Stephen J. Neame and
Lee L. Rubin and
Karen L. Philpott Blocking Cytochrome c Activity within
Intact Neurons Inhibits Apoptosis . . . 1583
Thomas E. Melby and
Charles N. Ciampaglio and
Gina Briscoe and
Harold P. Erickson The Symmetrical Structure of Structural
Maintenance of Chromosomes (SMC) and
MukB Proteins: Long, Antiparallel Coiled
Coils, Folded at a Flexible Hinge . . . 1595
Masayuki Ozawa and
Rolf Kemler The Membrane-proximal Region of the
E--Cadherin Cytoplasmic Domain Prevents
Dimerization and Negatively Regulates
Adhesion Activity . . . . . . . . . . . 1605
Nobutaka Hirokawa and
Sen Takeda Gene Targeting Studies Begin to Reveal
the Function of Neurofilament Proteins 1
Rita Abranches and
Alison F. Beven and
Luis Aragón-Alcaide and
Peter J. Shaw Transcription Sites Are Not Correlated
with Chromosome Territories in Wheat
Nuclei . . . . . . . . . . . . . . . . . 5
Amy K. Csink and
Steven Henikoff Large-scale Chromosomal Movements During
Interphase Progression in
\bionameDrosophila . . . . . . . . . . . 13
M. Oakes and
J. P. Aris and
J. S. Brockenbrough and
H. Wai and
L. Vu and
M. Nomura Mutational Analysis of the Structure and
Localization of the Nucleolus in the
Yeast \bionameSaccharomyces cerevisiae 23
Sui Huang and
Thomas J. Deerinck and
Mark H. Ellisman and
David L. Spector The Perinucleolar Compartment and
Transcription . . . . . . . . . . . . . 35
G. K. T. Chan and
B. T. Schaar and
T. J. Yen Characterization of the Kinetochore
Binding Domain of CENP--E Reveals
Interactions with the Kinetochore
Proteins CENP--F and hBUBR1 . . . . . . 49
Jonathan D. Gary and
Andrew E. Wurmser and
Cecilia J. Bonangelino and
Lois S. Weisman and
Scott D. Emr Fab1p Is Essential for PtdIns(3)P
5-Kinase Activity and the Maintenance of
Vacuolar Size and Membrane Homeostasis 65
A. Gibson and
C. E. Futter and
S. Maxwell and
E. H. Allchin and
M. Shipman and
J.-P. Kraehenbuhl and
D. Domingo and
G. Odorizzi and
I. S. Trowbridge and
C. R. Hopkins Sorting Mechanisms Regulating Membrane
Protein Traffic in the Apical
Transcytotic Pathway of Polarized MDCK
Cells . . . . . . . . . . . . . . . . . 81
Yasushi Izumi and
Tomonori Hirose and
Yoko Tamai and
Syu-ichi Hirai and
Yoji Nagashima and
Toyoshi Fujimoto and
Yo Tabuse and
Kenneth J. Kemphues and
Shigeo Ohno An Atypical PKC Directly Associates and
Colocalizes at the Epithelial Tight
Junction with ASIP, a Mammalian
Homologue of \bionameCaenorhabditis
elegans Polarity Protein PAR-3 . . . . . 95
James R. Bartles and
Lili Zheng and
Anli Li and
Allison Wierda and
Bin Chen Small Espin: a Third Actin-bundling
Protein and Potential Forked Protein
Ortholog in Brush Border Microvilli . . 107
Lewis G. Tilney and
Patricia S. Connelly and
Kelly A. Vranich and
Michael K. Shaw and
Gregory M. Guild Why Are Two Different Cross-linkers
Necessary for Actin Bundle Formation In
Vivo and What Does Each Cross-link
Contribute? . . . . . . . . . . . . . . 121
Marisa Segal and
Duncan J. Clarke and
Steven I. Reed Clb5-associated Kinase Activity is
Required Early in the Spindle Pathway
for Correct Preanaphase Nuclear
Positioning in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 135
Miri Yoon and
Robert D. Moir and
Veena Prahlad and
Robert D. Goldman Motile Properties of Vimentin
Intermediate Filament Networks in Living
Cells . . . . . . . . . . . . . . . . . 147
Veena Prahlad and
Miri Yoon and
Robert D. Moir and
Ronald D. Vale and
Robert D. Goldman Rapid Movements of Vimentin on
Microtubule Tracks: Kinesin-dependent
Assembly of Intermediate Filament
Networks . . . . . . . . . . . . . . . . 159
Mala V. Rao and
Megan K. Houseweart and
Toni L. Williamson and
Thomas O. Crawford and
Janet Folmer and
Don W. Cleveland Neurofilament-dependent Radial Growth of
Motor Axons and Axonal Organization of
Neurofilaments Does Not Require the
Neurofilament Heavy Subunit (NF--H) or
Its Phosphorylation . . . . . . . . . . 171
Qinzhang Zhu and
Michael Lindenbaum and
Françoise Levavasseur and
Hél\`ene Jacomy and
Jean-Pierre Julien Disruption of the NF--H Gene Increases
Axonal Microtubule Content and Velocity
of Neurofilament Transport: Relief of
Axonopathy Resulting from the Toxin $
\beta $,$ \beta $'-Iminodipropionitrile 183
Gregory A. Elder and
Victor L. Friedrich and
Chulho Kang and
Paolo Bosco and
Andrei Gourov and
Pang-Hsien Tu and
Bin Zhang and
Virginia M.-Y. Lee and
Robert A. Lazzarini Requirement of Heavy Neurofilament
Subunit in the Development of Axons with
Large Calibers . . . . . . . . . . . . . 195
Ing Swie Goping and
Atan Gross and
Josée N. Lavoie and
Mai Nguyen and
Ronald Jemmerson and
Kevin Roth and
Stanley J. Korsmeyer and
Gordon C. Shore Regulated Targeting of BAX to
Mitochondria . . . . . . . . . . . . . . 207
Robert Eskes and
Bruno Antonsson and
Astrid Osen-Sand and
Sylvie Montessuit and
Christoph Richter and
Rémy Sadoul and
Gonzalo Mazzei and
Anthony Nichols and
Jean-Claude Martinou Bax-induced Cytochrome C Release from
Mitochondria Is Independent of the
Permeability Transition Pore but Highly
Dependent on Mg$^{2+}$ Ions . . . . . . 217
Kumiko Samejima and
Shigenobu Toné and
Timothy J. Kottke and
Masato Enari and
Hideki Sakahira and
Carol A. Cooke and
Françoise Durrieu and
Luis M. Martins and
Shigekazu Nagata and
Scott H. Kaufmann and
William C. Earnshaw Transition from Caspase-dependent to
Caspase-independent Mechanisms at the
Onset of Apoptotic Execution . . . . . . 225
Xin Wu and
Jon E. Mogford and
Steven H. Platts and
George E. Davis and
Gerald A. Meininger and
Michael J. Davis Modulation of Calcium Current in
Arteriolar Smooth Muscle by $ \alpha_v
\beta_3 $ and $ \alpha_5 \beta_1 $
Integrin Ligands . . . . . . . . . . . . 241
Clotilde Gimond and
Christian Baudoin and
Ronald van der Neut and
Duco Kramer and
Jero Calafat and
Arnoud Sonnenberg Cre- loxP --mediated Inactivation of the
$ \alpha $6A Integrin Splice Variant In
Vivo: Evidence for a Specific Functional
Role of $ \alpha $6A in Lymphocyte
Migration but Not in Heart Development 253
Sandrine Bourdoulous and
Gertraud Orend and
Deidre A. MacKenna and
Renata Pasqualini and
Erkki Ruoslahti Fibronectin Matrix Regulates Activation
of RHO and CDC42 GTPases and Cell Cycle
Progression . . . . . . . . . . . . . . 267
Thoru Pederson Growth Factors in the Nucleolus? . . . . 279
Rey-Huei Chen and
Andrej Shevchenko and
Matthias Mann and
Andrew W. Murray Spindle Checkpoint Protein Xmad1
Recruits Xmad2 to Unattached
Kinetochores . . . . . . . . . . . . . . 283
Tom Misteli and
Javier F. Cáceres and
Jade Q. Clement and
Adrian R. Krainer and
Miles F. Wilkinson and
David L. Spector Serine Phosphorylation of SR Proteins Is
Required for Their Recruitment to Sites
of Transcription In Vivo . . . . . . . . 297
Andrea Herold and
Ray Truant and
Heather Wiegand and
Bryan R. Cullen Determination of the Functional Domain
Organization of the Importin $ \alpha $
Nuclear Import Factor . . . . . . . . . 309
David S. Nelson and
Cecilia Alvarez and
Ya-sheng Gao and
Rafael García-Mata and
Elizabeth Fialkowski and
Elizabeth Sztul The Membrane Transport Factor TAP/p115
Cycles between the Golgi and Earlier
Secretory Compartments and Contains
Distinct Domains Required for Its
Localization and Function . . . . . . . 319
Denichiro Otsuga and
Brian R. Keegan and
Ellen Brisch and
John W. Thatcher and
Greg J. Hermann and
William Bleazard and
Janet M. Shaw The Dynamin-related GTPase, Dnm1p,
Controls Mitochondrial Morphology in
Yeast . . . . . . . . . . . . . . . . . 333
Elena Smirnova and
Dixie-Lee Shurland and
Sergey N. Ryazantsev and
Alexander M. van der Bliek A Human Dynamin-related Protein Controls
the Distribution of Mitochondria . . . . 351
Greg J. Hermann and
John W. Thatcher and
John P. Mills and
Karen G. Hales and
Margaret T. Fuller and
Jodi Nunnari and
Janet M. Shaw Mitochondrial Fusion in Yeast Requires
the Transmembrane GTPase Fzo1p . . . . . 359
Jennifer Philips and
Ira Herskowitz Identification of Kel1p, a Kelch
Domain-containing Protein Involved in
Cell Fusion and Morphology in
\bionameSaccharomyces cerevisiae . . . . 375
Mikio Furuse and
Hiroyuki Sasaki and
Kazushi Fujimoto and
Shoichiro Tsukita A Single Gene Product, Claudin-1 or -2,
Reconstitutes Tight Junction Strands and
Recruits Occludin in Fibroblasts . . . . 391
Jong-Sun Kang and
Philip J. Mulieri and
Cary Miller and
David A. Sassoon and
Robert S. Krauss CDO, A Robo-related Cell Surface Protein
that Mediates Myogenic Differentiation 403
Janos Demeter and
Shelley Sazer imp2, a New Component of the Actin Ring
in the Fission Yeast
\bionameSchizosaccharomyces pombe . . . 415
Mark L. Borowsky and
Richard O. Hynes Layilin, A Novel Talin-binding
Transmembrane Protein Homologous with
C-type Lectins, is Localized in Membrane
Ruffles . . . . . . . . . . . . . . . . 429
Gabriela Paglini and
Patricia Kunda and
Santiago Quiroga and
Kenneth Kosik and
Alfredo Cáceres Suppression of Radixin and Moesin Alters
Growth Cone Morphology, Motility, and
Process Formation In Primary Cultured
Neurons . . . . . . . . . . . . . . . . 443
David S. Park and
Erick J. Morris and
Jaya Padmanabhan and
Michael L. Shelanski and
Herbert M. Geller and
Lloyd A. Greene Cyclin-dependent Kinases Participate in
Death of Neurons Evoked by DNA-damaging
Agents . . . . . . . . . . . . . . . . . 457
Kevin M. McGowan and
Pierre A. Coulombe Onset of Keratin 17 Expression Coincides
with the Definition of Major Epithelial
Lineages during Skin Development . . . . 469
Elizabeth Hutton and
Rudolph D. Paladini and
Qian-Chun Yu and
Mei Yen and
Pierre A. Coulombe and
Elaine Fuchs Functional Differences between Keratins
of Stratified and Simple Epithelia . . . 487
Péter Várnai and
Tamás Balla Visualization of Phosphoinositides That
Bind Pleckstrin Homology Domains:
Calcium- and Agonist-induced Dynamic
Changes and Relationship to Myo-[$^3$
H]inositol-labeled Phosphoinositide
Pools . . . . . . . . . . . . . . . . . 501
Yasuhito Shirai and
Kaori Kashiwagi and
Keiko Yagi and
Norio Sakai and
Naoaki Saito Distinct Effects of Fatty Acids on
Translocation of $ \gamma $- and $
\epsilon $-Subspecies of Protein Kinase
C . . . . . . . . . . . . . . . . . . . 511
Janne Balsamo and
Carlos Arregui and
TinChung Leung and
Jack Lilien The Nonreceptor Protein Tyrosine
Phosphatase PTP1B Binds to the
Cytoplasmic Domain of N--Cadherin and
Regulates the Cadherin--Actin Linkage 523
Catherin Niemann and
Volker Brinkmann and
Eva Spitzer and
Guido Hartmann and
Martin Sachs and
Helga Naundorf and
Walter Birchmeier Reconstitution of Mammary Gland
Development In Vitro: Requirement of
c-met and c-erbB2 Signaling for
Branching and Alveolar Morphogenesis . . 533
Du\vsko Ili\'c and
Eduardo A. C. Almeida and
David D. Schlaepfer and
Paul Dazin and
Shinichi Aizawa and
Caroline H. Damsky Extracellular Matrix Survival Signals
Transduced by Focal Adhesion Kinase
Suppress p53-mediated Apoptosis . . . . 547
Emmanuelle Martini and
Dani\`ele M. J. Roche and
Kathrin Marheineke and
Alain Verreault and
Genevi\`eve Almouzni Recruitment of Phosphorylated Chromatin
Assembly Factor 1 to Chromatin after UV
Irradiation of Human Cells . . . . . . . 563
Birthe Fahrenkrog and
Eduard C. Hurt and
Ueli Aebi and
Nelly Panté Molecular Architecture of the Yeast
Nuclear Pore Complex: Localization of
Nsp1p Subcomplexes . . . . . . . . . . . 577
Anne Spang and
Randy Schekman Reconstitution of Retrograde Transport
from the Golgi to the ER In Vitro . . . 589
Irina Majoul and
Kai Sohn and
Felix Theodor Wieland and
Rainer Pepperkok and
Mariagrazia Pizza and
Jörg Hillemann and
Hans-Dieter Söling KDEL Receptor (Erd2p)-mediated
Retrograde Transport of the Cholera
Toxin A Subunit from the Golgi Involves
COPI, p23, and the COOH Terminus of
Erd2p . . . . . . . . . . . . . . . . . 601
Joanne Sloan-Lancaster and
John Presley and
Jan Ellenberg and
Tetsuo Yamazaki and
Jennifer Lippincott-Schwartz and
Lawrence E. Samelson ZAP-70 Association with T Cell Receptor
$ \zeta $ (TCR$ \zeta $): Fluorescence
Imaging of Dynamic Changes upon Cellular
Stimulation . . . . . . . . . . . . . . 613
Sandra Fanchiotti and
Fabiana Fernández and
Cecilia D'Alessio and
Armando J. Parodi The UDP--Glc: Glycoprotein
Glucosyltransferase Is Essential for
\bionameSchizosaccharomyces pombe
Viability under Conditions of Extreme
Endoplasmic Reticulum Stress . . . . . . 625
Thomas M. Stulnig and
Markus Berger and
Thomas Sigmund and
Daniel Raederstorff and
Hannes Stockinger and
Werner Waldhäusl Polyunsaturated Fatty Acids Inhibit T
Cell Signal Transduction by Modification
of Detergent-insoluble Membrane Domains 637
Qinshi Jiang and
Daniel Mak and
Sreenivas Devidas and
Erik M. Schwiebert and
Alvina Bragin and
Yulong Zhang and
William R. Skach and
William B. Guggino and
J. Kevin Foskett and
John F. Engelhardt Cystic Fibrosis Transmembrane
Conductance Regulator--associated ATP
Release Is Controlled by a Chloride
Sensor . . . . . . . . . . . . . . . . . 645
Mar Carmena and
Maria Giovanna Riparbelli and
Gianluca Minestrini and
Álvaro M. Tavares and
Richard Adams and
Giuliano Callaini and
David M. Glover Drosophila Polo Kinase Is Required for
Cytokinesis . . . . . . . . . . . . . . 659
Torsten Wittmann and
Haralabia Boleti and
Claude Antony and
Eric Karsenti and
Isabelle Vernos Localization of the Kinesin-like Protein
Xklp2 to Spindle Poles Requires a
Leucine Zipper, a Microtubule-associated
Protein, and Dynein . . . . . . . . . . 673
Aaron F. Straight and
John W. Sedat and
Andrew W. Murray Time-Lapse Microscopy Reveals Unique
Roles for Kinesins during Anaphase in
Budding Yeast . . . . . . . . . . . . . 687
Martin Tögel and
Gerhard Wiche and
Friedrich Propst Novel Features of the Light Chain of
Microtubule-associated Protein MAP1B:
Microtubule Stabilization, Self
Interaction, Actin Filament Binding, and
Regulation by the Heavy Chain . . . . . 695
Christopher W. Carroll and
Roger Altman and
David Schieltz and
John R. Yates and
Douglas Kellogg The Septins Are Required for the
Mitosis-specific Activation of the Gin4
Kinase . . . . . . . . . . . . . . . . . 709
Mark S. Longtine and
Hanna Fares and
John R. Pringle Role of the Yeast Gin4p Protein Kinase
in Septin Assembly and the Relationship
between Septin Assembly and Septin
Function . . . . . . . . . . . . . . . . 719
Jennifer A. Frazier and
Mei Lie Wong and
Mark S. Longtine and
John R. Pringle and
Matthias Mann and
Timothy J. Mitchison and
Christine Field Polymerization of Purified Yeast
Septins: Evidence That Organized
Filament Arrays May Not Be Required for
Septin Function . . . . . . . . . . . . 737
Donald S. Sullivan and
Sue Biggins and
Mark D. Rose The Yeast Centrin, Cdc31p, and the
Interacting Protein Kinase, Kic1p, Are
Required for Cell Integrity . . . . . . 751
Luis A. Pardo and
Andrea Brüggemann and
Javier Camacho and
Walter Stühmer Cell Cycle--related Changes in the
Conducting Properties of r-eag K$^+$
Channels . . . . . . . . . . . . . . . . 767
A. Ebneth and
R. Godemann and
K. Stamer and
S. Illenberger and
B. Trinczek and
E.-M. Mandelkow and
E. Mandelkow Overexpression of Tau Protein Inhibits
Kinesin-dependent Trafficking of
Vesicles, Mitochondria, and Endoplasmic
Reticulum: Implications for Alzheimer's
Disease . . . . . . . . . . . . . . . . 777
Christian Kutzleb and
Gabriele Sanders and
Raina Yamamoto and
Xiaolu Wang and
Beate Lichte and
Elisabeth Petrasch-Parwez and
Manfred W. Kilimann Paralemmin, a
Prenyl--Palmitoyl--anchored
Phosphoprotein Abundant in Neurons and
Implicated in Plasma Membrane Dynamics
and Cell Process Formation . . . . . . . 795
Thomas W. White and
Daniel A. Goodenough and
David L. Paul Targeted Ablation of Connexin50 in Mice
Results in Microphthalmia and Zonular
Pulverulent Cataracts . . . . . . . . . 815
Francisco Miralles and
Tadej Battelino and
Paul Czernichow and
Raphael Scharfmann TGF-$ \beta $ Plays a Key Role in
Morphogenesis of the Pancreatic Islets
of Langerhans by Controlling the
Activity of the Matrix Metalloproteinase
MMP-2 . . . . . . . . . . . . . . . . . 827
Hyacinth Sterling and
Charles Saginario and
Agn\`es Vignery CD44 Occupancy Prevents Macrophage
Multinucleation . . . . . . . . . . . . 837
Daniela Taverna and
Marie-Helene Disatnik and
Helen Rayburn and
Roderick T. Bronson and
Joy Yang and
Thomas A. Rando and
Richard O. Hynes Dystrophic Muscle in Mice Chimeric for
Expression of $ \alpha $5 Integrin . . . 849
Carlos O. Arregui and
Janne Balsamo and
Jack Lilien Impaired Integrin-mediated Adhesion and
Signaling in Fibroblasts Expressing a
Dominant-negative Mutant PTP1B . . . . . 861
Yonchu Jenkins and
Michele McEntee and
Karsten Weis and
Warner C. Greene Characterization of HIV-1 Vpr Nuclear
Import: Analysis of Signals and Pathways 875
Jonathan S. Rosenblum and
Lucy F. Pemberton and
Neris Bonifaci and
Günter Blobel Nuclear Import and the Evolution of a
Multifunctional RNA-binding Protein . . 887
Wolfgang M. J. Obermann and
Holger Sondermann and
Alicia A. Russo and
Nikola P. Pavletich and
F. Ulrich Hartl In Vivo Function of Hsp90 Is Dependent
on ATP Binding and ATP Hydrolysis . . . 901
Catharine E. Johnson and
Paul T. Englund Changes in Organization of Crithidia
fasciculata Kinetoplast DNA Replication
Proteins during the Cell Cycle . . . . . 911
Susana Silberstein and
Gabriel Schlenstedt and
Pam A. Silver and
Reid Gilmore A Role for the DnaJ Homologue Scj1p in
Protein Folding in the Yeast Endoplasmic
Reticulum . . . . . . . . . . . . . . . 921
Todd B. Reynolds and
B. Diane Hopkins and
Matthew R. Lyons and
Todd R. Graham The High Osmolarity Glycerol Response
(HOG) MAP Kinase Pathway Controls
Localization of a Yeast Golgi
Glycosyltransferase . . . . . . . . . . 935
Gongyi Shi and
Victor Faúndez and
Jack Roos and
Esteban C. Dell'Angelica and
Regis B. Kelly Neuroendocrine Synaptic Vesicles Are
Formed In Vitro by Both
Clathrin-dependent and
Clathrin-independent Pathways . . . . . 947
Rytis Prekeris and
Judith Klumperman and
Yu A. Chen and
Richard H. Scheller Syntaxin 13 Mediates Cycling of Plasma
Membrane Proteins via Tubulovesicular
Recycling Endosomes . . . . . . . . . . 957
Frédéric Mallard and
Claude Antony and
Dani\`ele Tenza and
Jean Salamero and
Bruno Goud and
Ludger Johannes Direct Pathway from Early/Recycling
Endosomes to the Golgi Apparatus
Revealed through the Study of Shiga
Toxin B-fragment Transport . . . . . . . 973
Andrei Kouranov and
Xuejun Chen and
Bruno Fuks and
Danny J. Schnell Tic20 and Tic22 Are New Components of
the Protein Import Apparatus at the
Chloroplast Inner Envelope Membrane . . 991
G. Duménil and
J. C. Olivo and
S. Pellegrini and
M. Fellous and
P. J. Sansonetti and
G. Tran Van Nhieu Interferon $ \alpha $ Inhibits a
Src-mediated Pathway Necessary for
Shigella -induced Cytoskeletal
Rearrangements in Epithelial Cells . . . 1003
Carol C. Gregorio and
Karoly Trombitás and
Thomas Centner and
Bernhard Kolmerer and
Gunter Stier and
Kathleen Kunke and
Koichi Suzuki and
Franz Obermayr and
Bernhard Herrmann and
Henk Granzier and
Hiroyuki Sorimachi and
Siegfried Labeit The NH$_2$ Terminus of Titin Spans the
Z--Disc: Its Interaction with a Novel
19-kD Ligand (T-cap) Is Required for
Sarcomeric Integrity . . . . . . . . . . 1013
Christian Hofmann and
Iain M. Cheeseman and
Bruce L. Goode and
Kent L. McDonald and
Georjana Barnes and
David G. Drubin Saccharomyces cerevisiae Duo1p and
Dam1p, Novel Proteins Involved in
Mitotic Spindle Function . . . . . . . . 1029
Masafumi Nakamura and
Hirohisa Masuda and
Johji Horii and
Kei-ichi Kuma and
Nobuhiko Yokoyama and
Tomoyuki Ohba and
Hideo Nishitani and
Takashi Miyata and
Masao Tanaka and
Takeharu Nishimoto When Overexpressed, a Novel Centrosomal
Protein, RanBPM, Causes Ectopic
Microtubule Nucleation Similar to $
\gamma $-Tubulin . . . . . . . . . . . . 1041
Kristen J. Verhey and
Donna L. Lizotte and
Tatiana Abramson and
Linda Barenboim and
Bruce J. Schnapp and
Tom A. Rapoport Light Chain-dependent Regulation of
Kinesin's Interaction with Microtubules 1053
Dean J. Burkin and
Maojian Gu and
Bradley L. Hodges and
James T. Campanelli and
Stephen J. Kaufman A Functional Role for Specific Spliced
Variants of the $ \alpha $7$ \beta $1
Integrin in Acetylcholine Receptor
Clustering . . . . . . . . . . . . . . . 1067
Stanislav Zakharenko and
Sergey Popov Dynamics of Axonal Microtubules Regulate
the Topology of New Membrane Insertion
into the Growing Neurites . . . . . . . 1077
Angeliki Malliri and
Marc Symons and
Robert F. Hennigan and
Adam F. L. Hurlstone and
Richard F. Lamb and
Tricia Wheeler and
Bradford W. Ozanne The Transcription Factor AP-1 Is
Required for EGF-induced Activation of
Rho-like GTPases, Cytoskeletal
Rearrangements, Motility, and In Vitro
Invasion of A431 Cells . . . . . . . . . 1087
Francesca M. Spagnoli and
Laura Amicone and
Marco Tripodi and
Mary C. Weiss Identification of a Bipotential
Precursor Cell in Hepatic Cell Lines
Derived from Transgenic Mice Expressing
Cyto--Met in the Liver . . . . . . . . . 1101
Shinji Imai and
Marko Kaksonen and
Erkki Raulo and
Tarja Kinnunen and
Carole Fages and
Xiaojuan Meng and
Merja Lakso and
Heikki Rauvala Osteoblast Recruitment and Bone
Formation Enhanced by Cell
Matrix--associated Heparin-binding
Growth-associated Molecule (HB--GAM) . . 1113
Daqing W. Hartwell and
Tanya N. Mayadas and
Gaëtan Berger and
Paul S. Frenette and
Helen Rayburn and
Richard O. Hynes and
Denisa D. Wagner Role of P--Selectin Cytoplasmic Domain
in Granular Targeting In Vivo and in
Early Inflammatory Responses . . . . . . 1129
Richard K. Bruick and
Stephen P. Mayfield Processing of the psbA 5' Untranslated
Region in Chlamydomonas reinhardtii
Depends upon Factors Mediating Ribosome
Association . . . . . . . . . . . . . . 1145
Ingrid Markovic and
Helena Pulyaeva and
Alexander Sokoloff and
Leonid V. Chernomordik Membrane Fusion Mediated by Baculovirus
gp64 Involves Assembly of Stable gp64
Trimers into Multiprotein Aggregates . . 1155
Doris David and
Sumathy Sundarababu and
Jeffrey E. Gerst Involvement of Long Chain Fatty Acid
Elongation in the Trafficking of
Secretory Vesicles in Yeast . . . . . . 1167
Liwen Jiang and
John C. Rogers Integral Membrane Protein Sorting to
Vacuoles in Plant Cells: Evidence for
Two Pathways . . . . . . . . . . . . . . 1183
Kristen McArdle and
Taylor StC. Allen and
Elizabeth A. Bucher Ca$^{2+}$-dependent Muscle Dysfunction
Caused by Mutation of the
\bionameCaenorhabditis elegans Troponin
T-1 Gene . . . . . . . . . . . . . . . . 1201
José M. Barral and
Christopher C. Bauer and
Irving Ortiz and
Henry F. Epstein Unc-45 Mutations in
\bionameCaenorhabditis elegans Implicate
a CRO1/She4p-like Domain in Myosin
Assembly . . . . . . . . . . . . . . . . 1215
Toshihisa Ohtsuka and
Hiroyuki Nakanishi and
Wataru Ikeda and
Ayako Satoh and
Yumiko Momose and
Hideo Nishioka and
Yoshimi Takai Nexilin: a Novel Actin Filament-binding
Protein Localized at Cell--Matrix
Adherens Junction . . . . . . . . . . . 1227
Susan M. Beckwith and
Christian H. Roghi and
Bo Liu and
N. Ronald Morris The ``8-kD'' Cytoplasmic Dynein Light
Chain Is Required for Nuclear Migration
and for Dynein Heavy Chain Localization
in Aspergillus nidulans . . . . . . . . 1239
Yoshihiro Yasui and
Mutsuki Amano and
Koh-ichi Nagata and
Naoyuki Inagaki and
Hideo Nakamura and
Hideyuki Saya and
Kozo Kaibuchi and
Masaki Inagaki Roles of Rho-associated Kinase in
Cytokinesis; Mutations in Rho-associated
Kinase Phosphorylation Sites Impair
Cytokinetic Segregation of Glial
Filaments . . . . . . . . . . . . . . . 1249
Dan Strumpf and
Talila Volk Kakapo, a Novel Cytoskeletal-associated
Protein Is Essential for the Restricted
Localization of the Neuregulin-like
Factor, Vein, at the Muscle--Tendon
Junction Site . . . . . . . . . . . . . 1259
Stephen L. Gregory and
Nicholas H. Brown kakapo, a Gene Required for Adhesion
Between and Within Cell Layers in
\bionameDrosophila, Encodes a Large
Cytoskeletal Linker Protein Related to
Plectin and Dystrophin . . . . . . . . . 1271
Andreas Prokop and
Jay Uhler and
John Roote and
Michael Bate The kakapo Mutation Affects Terminal
Arborization and Central Dendritic
Sprouting of \bionameDrosophila
Motorneurons . . . . . . . . . . . . . . 1283
Daixing Zhou and
Stephen Lambert and
Peter L. Malen and
Scott Carpenter and
Linda M. Boland and
Vann Bennett Ankyrin$_G$ Is Required for Clustering
of Voltage-gated Na Channels at Axon
Initial Segments and for Normal Action
Potential Firing . . . . . . . . . . . . 1295
Paula Scotland and
Daixing Zhou and
Helene Benveniste and
Vann Bennett Nervous System Defects of Ankyrin$_B$
(-/-) Mice Suggest Functional Overlap
between the Cell Adhesion Molecule L1
and 440-kD Ankyrin$_B$ in Premyelinated
Axons . . . . . . . . . . . . . . . . . 1305
H. Steven Wiley and
Margaret F. Woolf and
Lee K. Opresko and
Patrick M. Burke and
Birgit Will and
Jeffrey R. Morgan and
Douglas A. Lauffenburger Removal of the Membrane-anchoring Domain
of Epidermal Growth Factor Leads to
Intracrine Signaling and Disruption of
Mammary Epithelial Cell Organization . . 1317
Irmgard Irminger-Finger and
Jesus V. Soriano and
Genevi\`eve Vaudan and
Roberto Montesano and
André-Pascal Sappino In Vitro Repression of Brca1-associated
RING Domain Gene, Bard1, Induces
Phenotypic Changes in Mammary Epithelial
Cells . . . . . . . . . . . . . . . . . 1329
Thomas Korff and
Hellmut G. Augustin Integration of Endothelial Cells in
Multicellular Spheroids Prevents
Apoptosis and Induces Differentiation 1341
Atsuo Kawahara and
Yoshiyuki Ohsawa and
Hirotaka Matsumura and
Yasuo Uchiyama and
Shigekazu Nagata Caspase-independent Cell Killing by
Fas-associated Protein with Death Domain 1353
Jacques Huot and
François Houle and
Simon Rousseau and
Réna G. Deschesnes and
Girish M. Shah and
Jacques Landry SAPK2\slash p38-dependent F--Actin
Reorganization Regulates Early Membrane
Blebbing during Stress-induced Apoptosis 1361
Jianguo Gu and
Masahito Tamura and
Kenneth M. Yamada Tumor Suppressor PTEN Inhibits Integrin-
and Growth Factor--mediated
Mitogen-activated Protein (MAP) Kinase
Signaling Pathways . . . . . . . . . . . 1375
Eva E. Sander and
Sanne van Delft and
Jean P. ten Klooster and
Tim Reid and
Rob A. van der Kammen and
Frits Michiels and
John G. Collard Matrix-dependent Tiam1/Rac Signaling in
Epithelial Cells Promotes Either
Cell--Cell Adhesion or Cell Migration
and Is Regulated by Phosphatidylinositol
3-Kinase . . . . . . . . . . . . . . . . 1385
Attila Aszódi and
Danny Chan and
Ernst Hunziker and
John F. Bateman and
Reinhard Fässler Collagen II Is Essential for the Removal
of the Notochord and the Formation of
Intervertebral Discs . . . . . . . . . . 1399
Hong Ma and
Jagath Samarabandu and
Rekandu S. Devdhar and
Raj Acharya and
Ping-chin Cheng and
Chunling Meng and
Ronald Berezney Spatial and Temporal Dynamics of DNA
Replication Sites in Mammalian Cells . . 1415
Robert Hock and
Ulrich Scheer and
Michael Bustin Chromosomal Proteins HMG-14 and HMG-17
Are Released from Mitotic Chromosomes
and Imported into the Nucleus by Active
Transport . . . . . . . . . . . . . . . 1427
Fabien Cubizolles and
Vincent Legagneux and
René Le Guellec and
Isabelle Chartrain and
Rustem Uzbekov and
Chris Ford and
Katherine Le Guellec pEg7, a New \bionameXenopus Protein
Required for Mitotic Chromosome
Condensation in Egg Extracts . . . . . . 1437
Markus Albertini and
Lucy F. Pemberton and
Jonathan S. Rosenblum and
Günter Blobel A Novel Nuclear Import Pathway for the
Transcription Factor TFIIS . . . . . . . 1447
Matthew K. Perez and
Henry L. Paulson and
Sagun J. Pendse and
Sarah J. Saionz and
Nancy M. Bonini and
Randall N. Pittman Recruitment and the Role of Nuclear
Localization in Polyglutamine-mediated
Aggregation . . . . . . . . . . . . . . 1457
Laxman Gangwani and
Monique Mikrut and
Zoya Galcheva-Gargova and
Roger J. Davis Interaction of ZPR1 with Translation
Elongation Factor-1$ \alpha $ in
Proliferating Cells . . . . . . . . . . 1471
Koret Hirschberg and
Chad M. Miller and
Jan Ellenberg and
John F. Presley and
Eric D. Siggia and
Robert D. Phair and
Jennifer Lippincott-Schwartz Kinetic Analysis of Secretory Protein
Traffic and Characterization of Golgi to
Plasma Membrane Transport Intermediates
in Living Cells . . . . . . . . . . . . 1485
Brian Storrie and
Jamie White and
Sabine Röttger and
Ernst H. K. Stelzer and
Tatsuo Suganuma and
Tommy Nilsson Recycling of Golgi-resident
Glycosyltransferases through the ER
Reveals a Novel Pathway and Provides an
Explanation for Nocodazole-induced Golgi
Scattering . . . . . . . . . . . . . . . 1505
Rui Li and
Philippe Rieu and
Diana L. Griffith and
David Scott and
M. Amin Arnaout Two Functional States of the CD11b
A--Domain: Correlations with Key
Features of Two Mn$^{2+}$-complexed
Crystal Structures . . . . . . . . . . . 1523
Folma Buss and
John Kendrick-Jones and
Corinne Lionne and
Alex E. Knight and
Graham P. Côté and
J. Paul Luzio The Localization of Myosin VI at the
Golgi Complex and Leading Edge of
Fibroblasts and Its Phosphorylation and
Recruitment into Membrane Ruffles of
A431 Cells after Growth Factor
Stimulation . . . . . . . . . . . . . . 1535
M. Carolina Tuma and
Andrew Zill and
Nathalie Le Bot and
Isabelle Vernos and
Vladimir Gelfand Heterotrimeric Kinesin II Is the
Microtubule Motor Protein Responsible
for Pigment Dispersion in
\bionameXenopus Melanophores . . . . . . 1547
Nathalie Le Bot and
Claude Antony and
Jamie White and
Eric Karsenti and
Isabelle Vernos Role of Xklp3, a Subunit of the Xenopus
Kinesin II Heterotrimeric Complex, in
Membrane Transport between the
Endoplasmic Reticulum and the Golgi
Apparatus . . . . . . . . . . . . . . . 1559
Y. Bobinnec and
A. Khodjakov and
L. M. Mir and
C. L. Rieder and
B. Eddé and
M. Bornens Centriole Disassembly In Vivo and Its
Effect on Centrosome Structure and
Function in Vertebrate Cells . . . . . . 1575
Gianni Piperno and
Edward Siuda and
Scott Henderson and
Margarethe Segil and
Heikki Vaananen and
Massimo Sassaroli Distinct Mutants of Retrograde
Intraflagellar Transport (IFT) Share
Similar Morphological and Molecular
Defects . . . . . . . . . . . . . . . . 1591
Jürg Bähler and
Alexander B. Steever and
Sally Wheatley and
Yu-li Wang and
John R. Pringle and
Kathleen L. Gould and
Dannel McCollum Role of Polo Kinase and Mid1p in
Determining the Site of Cell Division in
Fission Yeast . . . . . . . . . . . . . 1603
Javier Jiménez and
Víctor J. Cid and
Rosa Cenamor and
María Yuste and
Gloria Molero and
César Nombela and
Miguel Sánchez Morphogenesis beyond Cytokinetic Arrest
in \bionameSaccharomyces cerevisiae . . 1617
Jill M. Schumacher and
Andy Golden and
Peter J. Donovan AIR-2: an Aurora/Ipl1-related Protein
Kinase Associated with Chromosomes and
Midbody Microtubules Is Required for
Polar Body Extrusion and Cytokinesis in
\bionameCaenorhabditis elegans Embryos 1635
Uma Siddhanta and
James McIlroy and
Amishi Shah and
Yitao Zhang and
Jonathan M. Backer Distinct Roles for the p110$ \alpha $
and hVPS34 Phosphatidylinositol
3'-Kinases in Vesicular Trafficking,
Regulation of the Actin Cytoskeleton,
and Mitogenesis . . . . . . . . . . . . 1647
Christy Job and
Leon Lagnado Calcium and Protein Kinase C Regulate
the Actin Cytoskeleton in the Synaptic
Terminal of Retinal Bipolar Cells . . . 1661
Stefan Kunz and
Marianne Spirig and
Claudia Ginsburg and
Andrea Buchstaller and
Philipp Berger and
Rainer Lanz and
Christoph Rader and
Lorenz Vogt and
Beat Kunz and
Peter Sonderegger Neurite Fasciculation Mediated by
Complexes of Axonin-1 and Ng Cell
Adhesion Molecule . . . . . . . . . . . 1673
Raquel S. Aloyz and
Shernaz X. Bamji and
Christine D. Pozniak and
Jean G. Toma and
Jasvinder Atwal and
David R. Kaplan and
Freda D. Miller P53 Is Essential for Developmental
Neuron Death as Regulated by the TrkA
and p75 Neurotrophin Receptors . . . . . 1691
Eija I. Korpelainen and
Marika J. Karkkainen and
Auri Tenhunen and
Merja Lakso and
Heikki Rauvala and
Matti Vierula and
Martti Parvinen and
Kari Alitalo Overexpression of VEGF in Testis and
Epididymis Causes Infertility in
Transgenic Mice: Evidence for
Nonendothelial Targets for VEGF . . . . 1705
Jeffrey H. Miner and
Jeanette Cunningham and
Joshua R. Sanes Roles for Laminin in Embryogenesis:
Exencephaly, Syndactyly, and
Placentopathy in Mice Lacking the
Laminin $ \alpha $5 Chain . . . . . . . 1713
G. Y. Huang and
E. S. Cooper and
K. Waldo and
M. L. Kirby and
N. B. Gilula and
C. W. Lo Gap Junction--mediated Cell--Cell
Communication Modulates Mouse Neural
Crest Migration . . . . . . . . . . . . 1725
Paul D. Lampe and
Beth P. Nguyen and
Susana Gil and
Marcia Usui and
John Olerud and
Yoshikazu Takada and
William G. Carter Cellular Interaction of Integrin $
\alpha $3$ \beta $1 with Laminin 5
Promotes Gap Junctional Communication 1735
Kathleen L. O'Connor and
Leslie M. Shaw and
Arthur M. Mercurio Release of cAMP Gating by the $ \alpha
$6$ \beta $4 Integrin Stimulates
Lamellae Formation and the Chemotactic
Migration of Invasive Carcinoma Cells 1749
Alexandra M. Ainsztein and
Stefanie E. Kandels-Lewis and
Alastair M. Mackay and
William C. Earnshaw INCENP Centromere and Spindle Targeting:
Identification of Essential Conserved
Motifs and Involvement of
Heterochromatin Protein HP1 . . . . . . 1763
Pascal Bernard and
Kevin Hardwick and
Jean-Paul Javerzat Fission Yeast Bub1 Is a Mitotic
Centromere Protein Essential for the
Spindle Checkpoint and the Preservation
of Correct Ploidy through Mitosis . . . 1775
Heidi J. Chial and
Michael P. Rout and
Thomas H. Giddings and
Mark Winey Saccharomyces cerevisiae Ndc1p Is a
Shared Component of Nuclear Pore
Complexes and Spindle Pole Bodies . . . 1789
Peter Bangs and
Brian Burke and
Christine Powers and
Roger Craig and
Aruna Purohit and
Stephen Doxsey Functional Analysis of Tpr:
Identification of Nuclear Pore Complex
Association and Nuclear Localization
Domains and a Role in mRNA Export . . . 1801
Marcello Marelli and
John D. Aitchison and
Richard W. Wozniak Specific Binding of the Karyopherin
Kap121p to a Subunit of the Nuclear Pore
Complex Containing Nup53p, Nup59p, and
Nup170p . . . . . . . . . . . . . . . . 1813
Sylvie Urbé and
Lesley J. Page and
Sharon A. Tooze Homotypic Fusion of Immature Secretory
Granules during Maturation in a
Cell-free Assay . . . . . . . . . . . . 1831
Jens R. Coorssen and
Paul S. Blank and
Masahiro Tahara and
Joshua Zimmerberg Biochemical and Functional Studies of
Cortical Vesicle Fusion: The SNARE
Complex and Ca$^{2+}$ Sensitivity . . . 1845
P. Edward Purdue and
Xudong Yang and
Paul B. Lazarow Pex18p and Pex21p, a Novel Pair of
Related Peroxins Essential for
Peroxisomal Targeting by the PTS2
Pathway . . . . . . . . . . . . . . . . 1859
Yoram Altschuler and
Shana M. Barbas and
Laura J. Terlecky and
Kitty Tang and
Stephen Hardy and
Keith E. Mostov and
Sandra L. Schmid Redundant and Distinct Functions for
Dynamin-1 and Dynamin-2 Isoforms . . . . 1871
Jennifer A. Johnston and
Cristina L. Ward and
Ron R. Kopito Aggresomes: a Cellular Response to
Misfolded Proteins . . . . . . . . . . . 1883
Xufeng Wu and
Blair Bowers and
Kang Rao and
Qin Wei and
John A. Hammer Visualization of Melanosome Dynamics
within Wild--Type and Dilute Melanocytes
Suggests a Paradigm for Myosin V
Function In Vivo . . . . . . . . . . . . 1899
Dorothy A. Schafer and
Matthew D. Welch and
Laura M. Machesky and
Paul C. Bridgman and
Shelley M. Meyer and
John A. Cooper Visualization and Molecular Analysis of
Actin Assembly in Living Cells . . . . . 1919
David W. Pruyne and
Daniel H. Schott and
Anthony Bretscher Tropomyosin-containing Actin Cables
Direct the Myo2p-dependent Polarized
Delivery of Secretory Vesicles in
Budding Yeast . . . . . . . . . . . . . 1931
John Lippincott and
Rong Li Dual Function of Cyk2, a cdc15/PSTPIP
Family Protein, in Regulating Actomyosin
Ring Dynamics and Septin Distribution 1947
Naoto Kobayashi and
Jochen Reiser and
Wilhelm Kriz and
Ryoko Kuriyama and
Peter Mundel Nonuniform Microtubular Polarity
Established by CHO1/MKLP1 Motor Protein
Is Necessary for Process Formation of
Podocytes . . . . . . . . . . . . . . . 1961
Venkatesh Kurvari and
Nick V. Grishin and
William J. Snell A Gamete-specific, Sex-limited
Homeodomain Protein in Chlamydomonas . . 1971
J. C. Norman and
D. Jones and
S. T. Barry and
M. R. Holt and
S. Cockcroft and
D. R. Critchley ARF1 Mediates Paxillin Recruitment to
Focal Adhesions and Potentiates
Rho-stimulated Stress Fiber Formation in
Intact and Permeabilized Swiss 3T3
Fibroblasts . . . . . . . . . . . . . . 1981
Ji-He Zhao and
Heinz Reiske and
Jun-Lin Guan Regulation of the Cell Cycle by Focal
Adhesion Kinase . . . . . . . . . . . . 1997
G. Ian Gallicano and
Panos Kouklis and
Christoph Bauer and
Mei Yin and
Valeri Vasioukhin and
Linda Degenstein and
Elaine Fuchs Desmoplakin Is Required Early in
Development for Assembly of Desmosomes
and Cytoskeletal Linkage . . . . . . . . 2009
Nam-On Ku and
Sara A. Michie and
Roy M. Soetikno and
Evelyn Z. Resurreccion and
Rosemary L. Broome and
M. Bishr Omary Mutation of a Major Keratin
Phosphorylation Site Predisposes to
Hepatotoxic Injury in Transgenic Mice 2023
Yiu-mo Chan and
Carsten G. Bönnemann and
Hart G. W. Lidov and
Louis M. Kunkel Molecular Organization of Sarcoglycan
Complex in Mouse Myotubes in Culture . . 2033
E. Kolossov and
B. K. Fleischmann and
Q. Liu and
W. Bloch and
S. Viatchenko-Karpinski and
O. Manzke and
G. J. Ji and
H. Bohlen and
K. Addicks and
J. Hescheler Functional Characteristics of ES
Cell--derived Cardiac Precursor Cells
Identified by Tissue-specific Expression
of the Green Fluorescent Protein . . . . 2045
Els Decoster and
Sigrid Cornelis and
Bart Vanhaesebroeck and
Walter Fiers Autocrine Tumor Necrosis Factor (TNF)
and Lymphotoxin (LT) $ \alpha $
Differentially Modulate Cellular
Sensitivity to TNF/LT-$ \alpha $
Cytotoxicity in L929 Cells . . . . . . . 2057
Hanna Debiec and
Erik Ilsò Christensen and
Pierre Marie Ronco The Cell Adhesion Molecule L1 Is
Developmentally Regulated in the Renal
Epithelium and Is Involved in Kidney
Branching Morphogenesis . . . . . . . . 2067
Tatiana V. Byzova and
Edward F. Plow Activation of $ \alpha_V $ $ \beta_3 $
on Vascular Cells Controls Recognition
of Prothrombin . . . . . . . . . . . . . 2081
Miwa Shiratori and
Sakae Sakamoto and
Noriyuki Suzuki and
Yoshiki Tokutake and
Yoichi Kawabe and
Takemi Enomoto and
Masanobu Sugimoto and
Makoto Goto and
Takehisa Matsumoto and
Yasuhiro Furuichi Detection by Epitope-defined Monoclonal
Antibodies of Werner DNA Helicases in
the Nucleoplasm and Their Upregulation
by Cell Transformation and
Immortalization . . . . . . . . . . . . 1
Thomas Haaf and
Elke Raderschall and
Gurucharan Reddy and
David C. Ward and
Charles M. Radding and
Efim I. Golub Sequestration of Mammalian
Rad51-Recombination Protein into
Micronuclei . . . . . . . . . . . . . . 11
Rachel Hellman and
Marc Vanhove and
Annabelle Lejeune and
Fred J. Stevens and
Linda M. Hendershot The In Vivo Association of BiP with
Newly Synthesized Proteins Is Dependent
on the Rate and Stability of Folding and
Not Simply on the Presence of Sequences
That Can Bind to BiP . . . . . . . . . . 21
Ross G. Vickery and
Mark von Zastrow Distinct Dynamin-dependent and
-independent Mechanisms Target
Structurally Homologous Dopamine
Receptors to Different Endocytic
Membranes . . . . . . . . . . . . . . . 31
Oliver Hobert and
Donald G. Moerman and
Kathleen A. Clark and
Mary C. Beckerle and
Gary Ruvkun A Conserved LIM Protein That Affects
Muscular Adherens Junction Integrity and
Mechanosensory Function in
\bionameCaenorhabditis elegans . . . . . 45
Noriyuki Kioka and
Shohei Sakata and
Takeshi Kawauchi and
Teruo Amachi and
Steven K. Akiyama and
Kenji Okazaki and
Christopher Yaen and
Kenneth M. Yamada and
Shin-ichi Aota Vinexin: a Novel Vinculin-binding
Protein with Multiple SH3 Domains
Enhances Actin Cytoskeletal Organization 59
Guisheng Zeng and
Mingjie Cai Regulation of the Actin Cytoskeleton
Organization in Yeast by a Novel
Serine/Threonine Kinase Prk1p . . . . . 71
Bruce L. Goode and
Jonathan J. Wong and
Anne-Christine Butty and
Matthias Peter and
Ashley L. McCormack and
John R. Yates and
David G. Drubin and
Georjana Barnes Coronin Promotes the Rapid Assembly and
Cross-linking of Actin Filaments and May
Link the Actin and Microtubule
Cytoskeletons in Yeast . . . . . . . . . 83
Georgios S. Diamantopoulos and
Franck Perez and
Holly V. Goodson and
Gérard Batelier and
Ronald Melki and
Thomas E. Kreis and
Janet E. Rickard Dynamic Localization of CLIP-170 to
Microtubule Plus Ends Is Coupled to
Microtubule Assembly . . . . . . . . . . 99
Becket Feierbach and
Eva Nogales and
Kenneth H. Downing and
Tim Stearns Alf1p, a CLIP-170 Domain-containing
Protein, Is Functionally and Physically
Associated with $ \alpha $-Tubulin . . . 113
David J. Sharp and
Kent L. McDonald and
Heather M. Brown and
Heinrich J. Matthies and
Claire Walczak and
Ron D. Vale and
Timothy J. Mitchison and
Jonathan M. Scholey The Bipolar Kinesin, KLP61F, Cross-links
Microtubules within Interpolar
Microtubule Bundles of
\bionameDrosophila Embryonic Mitotic
Spindles . . . . . . . . . . . . . . . . 125
Daniel B. Constam and
Elizabeth J. Robertson Regulation of Bone Morphogenetic Protein
Activity by Pro Domains and Proprotein
Convertases . . . . . . . . . . . . . . 139
Neil Smyth and
H. Seda Vatansever and
Patricia Murray and
Michael Meyer and
Christian Frie and
Mats Paulsson and
David Edgar Absence of Basement Membranes after
Targeting the LAMC1 Gene Results in
Embryonic Lethality Due to Failure of
Endoderm Differentiation . . . . . . . . 151
Noriyuki Tsumaki and
Kazuhiro Tanaka and
Eri Arikawa-Hirasawa and
Takanobu Nakase and
Tomoatsu Kimura and
J. Terrig Thomas and
Takahiro Ochi and
Frank P. Luyten and
Yoshihiko Yamada Role of CDMP-1 in Skeletal
Morphogenesis: Promotion of Mesenchymal
Cell Recruitment and Chondrocyte
Differentiation . . . . . . . . . . . . 161
Ravinder Pabla and
Andrew S. Weyrich and
Dan A. Dixon and
Paul F. Bray and
Thomas M. McIntyre and
Stephen M. Prescott and
Guy A. Zimmerman Integrin-dependent Control of
Translation: Engagement of Integrin $
\alpha_{IIb} $ $ \beta_3 $ Regulates
Synthesis of Proteins in Activated Human
Platelets . . . . . . . . . . . . . . . 175
Shuqi Chen and
Timothy A. Springer An Automatic Braking System That
Stabilizes Leukocyte Rolling by an
Increase in Selectin Bond Number with
Shear . . . . . . . . . . . . . . . . . 185
Stefan Kircher and
Frank Wellmer and
Peter Nick and
Alexander Rügner and
Eberhard Schäfer and
Klaus Harter Nuclear Import of the Parsley bZIP
Transcription Factor CPRF2 Is Regulated
by Phytochrome Photoreceptors . . . . . 201
Jonathan D. Moore and
Jing Yang and
Ray Truant and
Sally Kornbluth Nuclear Import of Cdk/Cyclin Complexes:
Identification of Distinct Mechanisms
for Import of Cdk2/Cyclin E and
Cdc2/Cyclin B1 . . . . . . . . . . . . . 213
Sheona Drummond and
Paul Ferrigno and
Carol Lyon and
Jackie Murphy and
Martin Goldberg and
Terry Allen and
Carl Smythe and
Christopher J. Hutchison Temporal Differences in the Appearance
of NEP--B78 and an LBR-like Protein
during \bionameXenopus Nuclear Envelope
Reassembly Reflect the Ordered
Recruitment of Functionally Discrete
Vesicle Types . . . . . . . . . . . . . 225
Maria Teresa Alonso and
Maria José Barrero and
Pedro Michelena and
Estela Carnicero and
Inmaculada Cuchillo and
Antonio G. García and
Javier García-Sancho and
Mayte Montero and
Javier Alvarez Ca$^{2+}$-induced Ca$^{2+}$ Release in
Chromaffin Cells Seen from inside the ER
with Targeted Aequorin . . . . . . . . . 241
Sarah T. South and
Stephen J. Gould Peroxisome Synthesis in the Absence of
Preexisting Peroxisomes . . . . . . . . 255
Jacomine Krijnse Locker and
Gareth Griffiths An Unconventional Role for Cytoplasmic
Disulfide Bonds in Vaccinia Virus
Proteins . . . . . . . . . . . . . . . . 267
Elizabeth A. Slee and
Mary T. Harte and
Ruth M. Kluck and
Beni B. Wolf and
Carlos A. Casiano and
Donald D. Newmeyer and
Hong-Gang Wang and
John C. Reed and
Donald W. Nicholson and
Emad S. Alnemri and
Douglas R. Green and
Seamus J. Martin Ordering the Cytochrome c-initiated
Caspase Cascade: Hierarchical Activation
of Caspases-2, -3, -6, -7, -8, and -10
in a Caspase-9-dependent Manner . . . . 281
David R. Mitchell and
Winfield S. Sale Characterization of a Chlamydomonas
Insertional Mutant that Disrupts
Flagellar Central Pair
Microtubule-associated Structures . . . 293
Christopher B. O'Connell and
Sally P. Wheatley and
Sohail Ahmed and
Yu-li Wang The Small GTP-binding Protein Rho
Regulates Cortical Activities in
Cultured Cells during Division . . . . . 305
Yoshihiko Yamakita and
Go Totsukawa and
Shigeko Yamashiro and
David Fry and
Xiaoe Zhang and
Steven K. Hanks and
Fumio Matsumura Dissociation of FAK/p130$^{\rm CAS}$
/c--Src Complex during Mitosis: Role of
Mitosis-specific Serine Phosphorylation
of FAK . . . . . . . . . . . . . . . . . 315
Farzad Esni and
Inge-Bert Täljedal and
Anne-Karina Perl and
Harold Cremer and
Gerhard Christofori and
Henrik Semb Neural Cell Adhesion Molecule (N-CAM) Is
Required for Cell Type Segregation and
Normal Ultrastructure in Pancreatic
Islets . . . . . . . . . . . . . . . . . 325
Christian A. Leppert and
Heike Diekmann and
Claudia Paul and
Ute Laessing and
Monika Marx and
Martin Bastmeyer and
Claudia A. O. Stuermer Neurolin Ig Domain 2 Participates in
Retinal Axon Guidance and Ig Domains 1
and 3 in Fasciculation . . . . . . . . . 339
Yun Zhong and
William M. Brieher and
Barry M. Gumbiner Analysis of C-cadherin Regulation during
Tissue Morphogenesis with an Activating
Antibody . . . . . . . . . . . . . . . . 351
Michael Buchert and
Stefan Schneider and
Virginia Meskenaite and
Mark T. Adams and
Eli Canaani and
Thomas Baechi and
Karin Moelling and
Christopher M. Hovens The Junction-associated Protein AF-6
Interacts and Clusters with Specific Eph
Receptor Tyrosine Kinases at Specialized
Sites of Cell--Cell Contact in the Brain 361
Ann T. J. Beliën and
Paolo A. Paganetti and
Martin E. Schwab Membrane-type 1 Matrix Metalloprotease
(MT1-MMP) Enables Invasive Migration of
Glioma Cells in Central Nervous System
White Matter . . . . . . . . . . . . . . 373
Joel L. Rosenbaum and
Douglas G. Cole and
Dennis R. Diener Intraflagellar Transport: The Eyes Have
It . . . . . . . . . . . . . . . . . . . 385
Ed Hurt and
Stefan Hannus and
Birgit Schmelzl and
Denise Lau and
David Tollervey and
George Simos A Novel In Vivo Assay Reveals Inhibition
of Ribosomal Nuclear Export in
Ran--Cycle and Nucleoporin Mutants . . . 389
Shun'ichi Kuroda and
Noritaka Nakagawa and
Chiharu Tokunaga and
Kenji Tatematsu and
Katsuyuki Tanizawa Mammalian Homologue of the
\bionameCaenorhabditis elegans UNC-76
Protein Involved in Axonal Outgrowth Is
a Protein Kinase C $ \zeta
$--interacting Protein . . . . . . . . . 403
Florian Überall and
Karina Hellbert and
Sonja Kampfer and
Karl Maly and
Andreas Villunger and
Martin Spitaler and
James Mwanjewe and
Gabriele Baier-Bitterlich and
Gottfried Baier and
Hans H. Grunicke Evidence That Atypical Protein Kinase
C-$ \lambda $ and Atypical Protein
Kinase C-$ \zeta $ Participate in
Ras-mediated Reorganization of the
F-actin Cytoskeleton . . . . . . . . . . 413
Tomomi Gotoh and
Masataka Mori Arginase II Downregulates Nitric Oxide
(NO) Production and Prevents NO-mediated
Apoptosis in Murine Macrophage-derived
RAW 264.7 Cells . . . . . . . . . . . . 427
Conrad L. Leung and
Dongming Sun and
Ronald K. H. Liem The Intermediate Filament Protein
Peripherin Is the Specific Interaction
Partner of Mouse BPAG1-n (Dystonin) in
Neurons . . . . . . . . . . . . . . . . 435
Thomas J. Koehnle and
Anthony Brown Slow Axonal Transport of Neurofilament
Protein in Cultured Neurons . . . . . . 447
Giuseppe D. Ciccotosto and
Martin R. Schiller and
Betty A. Eipper and
Richard E. Mains Induction of Integral Membrane PAM
Expression in AtT-20 Cells Alters the
Storage and Trafficking of POMC and PC1 459
Gregory J. Pazour and
Bethany L. Dickert and
George B. Witman The DHC1b (DHC2) Isoform of Cytoplasmic
Dynein Is Required for Flagellar
Assembly . . . . . . . . . . . . . . . . 473
J. A. Feijó and
J. Sainhas and
G. R. Hackett and
J. G. Kunkel and
P. K. Hepler Growing Pollen Tubes Possess a
Constitutive Alkaline Band in the Clear
Zone and a Growth-dependent Acidic Tip 483
Drazen Raucher and
Michael P. Sheetz Membrane Expansion Increases Endocytosis
Rate during Mitosis . . . . . . . . . . 497
Stanislav Zakharenko and
Sunghoe Chang and
Michael O'Donoghue and
Sergey V. Popov Neurotransmitter Secretion along Growing
Nerve Processes: Comparison with
Synaptic Vesicle Exocytosis . . . . . . 507
Qun Lu and
Mercedes Paredes and
Miguel Medina and
Jianhua Zhou and
Robert Cavallo and
Mark Peifer and
Lisa Orecchio and
Kenneth S. Kosik $ \delta $-catenin, an Adhesive
Junction--associated Protein Which
Promotes Cell Scattering . . . . . . . . 519
Paulina Niewiadomska and
Dorothea Godt and
Ulrich Tepass D E--Cadherin Is Required for
Intercellular Motility during
\bionameDrosophila Oogenesis . . . . . . 533
M. S. Chen and
E. A. C. Almeida and
A.-P. J. Huovila and
Y. Takahashi and
L. M. Shaw and
A. M. Mercurio and
J. M. White Evidence that Distinct States of the
Integrin $ \alpha $6$ \beta $1 Interact
with Laminin and an ADAM . . . . . . . . 549
Myl\`ene Vivinus-Nebot and
Michel Ticchioni and
Florence Mary and
Paul Hofman and
Vito Quaranta and
Patricia Rousselle and
Alain Bernard Laminin 5 in the Human Thymus: Control
of T Cell Proliferation via $ \alpha_6
\beta_4 $ Integrins . . . . . . . . . . 563
Iryna M. Ethell and
Yu Yamaguchi Cell Surface Heparan Sulfate
Proteoglycan Syndecan-2 Induces the
Maturation of Dendritic Spines in Rat
Hippocampal Neurons . . . . . . . . . . 575
M. Prakash Hande and
Enrique Samper and
Peter Lansdorp and
María A. Blasco Telomere Length Dynamics and Chromosomal
Instability in Cells Derived from
Telomerase Null Mice . . . . . . . . . . 589
Christian R. Eckmann and
Michael F. Jantsch The RNA-editing Enzyme ADAR1 Is
Localized to the Nascent
Ribonucleoprotein Matrix on
\bionameXenopus Lampbrush Chromosomes
but Specifically Associates with an
Atypical Loop . . . . . . . . . . . . . 603
Kelly P. Smith and
Phillip T. Moen and
Karen L. Wydner and
John R. Coleman and
Jeanne B. Lawrence Processing of Endogenous Pre-mRNAs in
Association with SC-35 Domains Is Gene
Specific . . . . . . . . . . . . . . . . 617
Luc A. Sabourin and
Adele Girgis-Gabardo and
Patrick Seale and
Atsushi Asakura and
Michael A. Rudnicki Reduced Differentiation Potential of
Primary MyoD -/- Myogenic Cells Derived
from Adult Skeletal Muscle . . . . . . . 631
Miki Hieda and
Taro Tachibana and
Fumihiko Yokoya and
Shingo Kose and
Naoko Imamoto and
Yoshihiro Yoneda A Monoclonal Antibody to the
COOH-terminal Acidic Portion of Ran
Inhibits Both the Recycling of Ran and
Nuclear Protein Import in Living Cells 645
Maarit Suomalainen and
Michel Y. Nakano and
Stephan Keller and
Karin Boucke and
Robert P. Stidwill and
Urs F. Greber Microtubule-dependent Plus- and Minus
End--directed Motilities Are Competing
Processes for Nuclear Targeting of
Adenovirus . . . . . . . . . . . . . . . 657
Masayoshi Fukasawa and
Masahiro Nishijima and
Kentaro Hanada Genetic Evidence for ATP-dependent
Endoplasmic Reticulum-to-Golgi Apparatus
Trafficking of Ceramide for
Sphingomyelin Synthesis in Chinese
Hamster Ovary Cells . . . . . . . . . . 673
Yih-Tai Chen and
Daniel B. Stewart and
W. James Nelson Coupling Assembly of the E-Cadherin/$
\beta $--Catenin Complex to Efficient
Endoplasmic Reticulum Exit and
Basal-lateral Membrane Targeting of
E-Cadherin in Polarized MDCK Cells . . . 687
Johnson Varkey and
Po Chen and
Ronald Jemmerson and
John M. Abrams Altered Cytochrome c Display Precedes
Apoptotic Cell Death in
\bionameDrosophila . . . . . . . . . . . 701
Kelly A. Shepard and
Michael P. Yaffe The Yeast Dynamin-like Protein, Mgm1p,
Functions on the Mitochondrial Outer
Membrane to Mediate Mitochondrial
Inheritance . . . . . . . . . . . . . . 711
Karen Oegema and
Christiane Wiese and
Ona C. Martin and
Ronald A. Milligan and
Akihiro Iwamatsu and
Timothy J. Mitchison and
Yixian Zheng Characterization of Two Related
\bionameDrosophila $ \gamma $-tubulin
Complexes that Differ in Their Ability
to Nucleate Microtubules . . . . . . . . 721
Go Totsukawa and
Yoshihiko Yamakita and
Shigeko Yamashiro and
Hiroshi Hosoya and
David J. Hartshorne and
Fumio Matsumura Activation of Myosin Phosphatase
Targeting Subunit by Mitosis-specific
Phosphorylation . . . . . . . . . . . . 735
Birgit Klages and
Ursula Brandt and
Melvin I. Simon and
Günter Schultz and
Stefan Offermanns Activation of G$_{12}$ /G$_{13}$ Results
in Shape Change and
Rho/Rho-Kinase-mediated Myosin Light
Chain Phosphorylation in Mouse Platelets 745
José M. Rodríguez-Frade and
Antonio J. Vila-Coro and
Ana Martín and
Marta Nieto and
Francisco Sánchez-Madrid and
Amanda E. I. Proudfoot and
Timothy N. C. Wells and
Carlos Martínez-A and
Mario Mellado Similarities and Differences in RANTES-
and (AOP)-RANTES--triggered Signals:
Implications for Chemotaxis . . . . . . 755
P. Hermann and
M. Armant and
E. Brown and
M. Rubio and
H. Ishihara and
D. Ulrich and
R. G. Caspary and
F. P. Lindberg and
R. Armitage and
C. Maliszewski and
G. Delespesse and
M. Sarfati The Vitronectin Receptor and its
Associated CD47 Molecule Mediates
Proinflammatory Cytokine Synthesis in
Human Monocytes by Interaction with
Soluble CD23 . . . . . . . . . . . . . . 767
Dwayne G. Stupack and
Erguang Li and
Steve A. Silletti and
Jacqueline A. Kehler and
Robert L. Geahlen and
Klaus Hahn and
Glen R. Nemerow and
David A. Cheresh Matrix Valency Regulates
Integrin-mediated Lymphoid Adhesion via
Syk Kinase . . . . . . . . . . . . . . . 777
Suneale Banerji and
Jian Ni and
Shu-Xia Wang and
Steven Clasper and
Jeffrey Su and
Raija Tammi and
Margaret Jones and
David G. Jackson LYVE-1, a New Homologue of the CD44
Glycoprotein, Is a Lymph-specific
Receptor for Hyaluronan . . . . . . . . 789
Richard A. Heil-Chapdelaine and
Neil R. Adames and
John A. Cooper Formin' the Connection between
Microtubules and the Cell Cortex . . . . 809
Erik M. M. Manders and
Hiroshi Kimura and
Peter R. Cook Direct Imaging of DNA in Living Cells
Reveals the Dynamics of Chromosome
Formation . . . . . . . . . . . . . . . 813
Francesca Sanvito and
Simonetta Piatti and
Antonello Villa and
Mario Bossi and
Giovanna Lucchini and
Pier Carlo Marchisio and
Stefano Biffo The $ \beta $4 Integrin Interactor
p27$^{\rm BBP}$ /eIF6 Is an Essential
Nuclear Matrix Protein Involved in 60S
Ribosomal Subunit Assembly . . . . . . . 823
Caterina Strambio-de-Castillia and
Günter Blobel and
Michael P. Rout Proteins Connecting the Nuclear Pore
Complex with the Nuclear Interior . . . 839
Nasrin Mesaeli and
Kimitoshi Nakamura and
Elena Zvaritch and
Peter Dickie and
Ewa Dziak and
Karl-Heinz Krause and
Michal Opas and
David H. MacLennan and
Marek Michalak Calreticulin Is Essential for Cardiac
Development . . . . . . . . . . . . . . 857
Daniel S. Chao and
Jesse C. Hay and
Shawn Winnick and
Rytis Prekeris and
Judith Klumperman and
Richard H. Scheller SNARE Membrane Trafficking Dynamics In
Vivo . . . . . . . . . . . . . . . . . . 869
Isabelle Martinou and
Solange Desagher and
Robert Eskes and
Bruno Antonsson and
Elisabeth André and
Stanislav Fakan and
Jean-Claude Martinou The Release of Cytochrome c from
Mitochondria during Apoptosis of
NGF-deprived Sympathetic Neurons Is a
Reversible Event . . . . . . . . . . . . 883
Solange Desagher and
Astrid Osen-Sand and
Anthony Nichols and
Robert Eskes and
Sylvie Montessuit and
Sandra Lauper and
Kinsey Maundrell and
Bruno Antonsson and
Jean-Claude Martinou Bid-induced Conformational Change of Bax
Is Responsible for Mitochondrial
Cytochrome c Release during Apoptosis 891
Gareth J. Griffiths and
Laurence Dubrez and
Clive P. Morgan and
Neil A. Jones and
Jenna Whitehouse and
Bernard M. Corfe and
Caroline Dive and
John A. Hickman Cell Damage-induced Conformational
Changes of the Pro--Apoptotic Protein
Bak In Vivo Precede the Onset of
Apoptosis . . . . . . . . . . . . . . . 903
Joseph F. Krebs and
Robert C. Armstrong and
Anu Srinivasan and
Teresa Aja and
Angela M. Wong and
Aileen Aboy and
Rob Sayers and
Bryan Pham and
Tam Vu and
Kim Hoang and
Donald S. Karanewsky and
Christian Leist and
Albert Schmitz and
Joe C. Wu and
Kevin J. Tomaselli and
Lawrence C. Fritz Activation of Membrane-associated
Procaspase-3 Is Regulated by Bcl-2 . . . 915
Pierre Gönczy and
Heinke Schnabel and
Titus Kaletta and
Ana Duran Amores and
Tony Hyman and
Ralf Schnabel Dissection of Cell Division Processes in
the One Cell Stage
\bionameCaenorhabditis elegans Embryo by
Mutational Analysis . . . . . . . . . . 927
Laifong Lee and
Saskia K. Klee and
Marie Evangelista and
Charles Boone and
David Pellman Control of Mitotic Spindle Position by
the \bionameSaccharomyces cerevisiae
Formin Bni1p . . . . . . . . . . . . . . 947
Rita K. Miller and
Dina Matheos and
Mark D. Rose The Cortical Localization of the
Microtubule Orientation Protein, Kar9p,
Is Dependent upon Actin and Proteins
Required for Polarization . . . . . . . 963
Paul Maddox and
E. Chin and
A. Mallavarapu and
E. Yeh and
E. D. Salmon and
K. Bloom Microtubule Dynamics from Mating through
the First Zygotic Division in the
Budding Yeast \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 977
William A. Kronert and
Angel Acebes and
Alberto Ferrús and
Sanford I. Bernstein Specific Myosin Heavy Chain Mutations
Suppress Troponin I Defects in
\bionameDrosophila Muscles . . . . . . . 989
Kenji Mandai and
Hiroyuki Nakanishi and
Ayako Satoh and
Kenichi Takahashi and
Keiko Satoh and
Hideo Nishioka and
Akira Mizoguchi and
Yoshimi Takai Ponsin/SH3P12: An l-Afadin- and
Vinculin-binding Protein Localized at
Cell--Cell and Cell--Matrix Adherens
Junctions . . . . . . . . . . . . . . . 1001
Alexandre Angers-Loustau and
Jean-François Côté and
Alain Charest and
Donald Dowbenko and
Susan Spencer and
Laurence A. Lasky and
Michel L. Tremblay Protein Tyrosine Phosphatase--PEST
Regulates Focal Adhesion Disassembly,
Migration, and Cytokinesis in
Fibroblasts . . . . . . . . . . . . . . 1019
Lan Zhou and
Eileen M. Kasperek and
Bruce J. Nicholson Dissection of the Molecular Basis of
pp60$^{v - src}$ Induced Gating of
Connexin 43 Gap Junction Channels . . . 1033
John D. Loike and
Long Cao and
Sadna Budhu and
Eugene E. Marcantonio and
Joseph El Khoury and
Stanley Hoffman and
Ted A. Yednock and
Samuel C. Silverstein Differential Regulation of $ \beta_1 $
Integrins by Chemoattractants Regulates
Neutrophil Migration through Fibrin . . 1047
S. Vijayakumar and
Jiro Takito and
Chinami Hikita and
Qais Al-Awqati Hensin Remodels the Apical Cytoskeleton
and Induces Columnarization of
Intercalated Epithelial Cells: Processes
that Resemble Terminal Differentiation 1057
Yong Zhu and
Anush Oganesian and
Douglas R. Keene and
Linda J. Sandell Type IIA Procollagen Containing the
Cysteine-rich Amino Propeptide Is
Deposited in the Extracellular Matrix of
Prechondrogenic Tissue and Binds to
TGF-$ \beta $1 and BMP-2 . . . . . . . . 1069
Tracey Michele Gant and
Crafford A. Harris and
Katherine L. Wilson Roles of LAP2 Proteins in Nuclear
Assembly and DNA Replication: Truncated
LAP2$ \beta $ Proteins Alter Lamina
Assembly, Envelope Formation, Nuclear
Size, and DNA Replication Efficiency in
\bionameXenopus laevis Extracts . . . . 1083
Beatriz M. A. Fontoura and
Günter Blobel and
Michael J. Matunis A Conserved Biogenesis Pathway for
Nucleoporins: Proteolytic Processing of
a 186-Kilodalton Precursor Generates
Nup98 and the Novel Nucleoporin, Nup96 1097
Jonathan R. Beauchamp and
Jennifer E. Morgan and
Charles N. Pagel and
Terence A. Partridge Dynamics of Myoblast Transplantation
Reveal a Discrete Minority of Precursors
with Stem Cell-like Properties as the
Myogenic Source . . . . . . . . . . . . 1113
Ennio Giordano and
Ivana Peluso and
Stefania Senger and
Maria Furia minifly, A \bionameDrosophila Gene
Required for Ribosome Biogenesis . . . . 1123
Mark S. Ladinsky and
David N. Mastronarde and
J. Richard McIntosh and
Kathryn E. Howell and
L. Andrew Staehelin Golgi Structure in Three Dimensions:
Functional Insights from the Normal Rat
Kidney Cell . . . . . . . . . . . . . . 1135
Wolfgang Girzalsky and
Peter Rehling and
Katharina Stein and
Julia Kipper and
Lars Blank and
Wolf-Hubert Kunau and
Ralf Erdmann Involvement of Pex13p in Pex14p
Localization and Peroxisomal Targeting
Signal $2$-dependent Protein Import into
Peroxisomes . . . . . . . . . . . . . . 1151
Christine Herrmann and
Elaheh Golkaramnay and
Elisabeth Inman and
Leonard Rome and
Walter Volknandt Recombinant Major Vault Protein Is
Targeted to Neuritic Tips of PC12 Cells 1163
Satoshi Katayama and
Dai Hirata and
Manuel Arellano and
Pilar Pérez and
Takashi Toda Fission Yeast $ \alpha $-Glucan Synthase
Mok1 Requires the Actin Cytoskeleton to
Localize the Sites of Growth and Plays
an Essential Role in Cell Morphogenesis
Downstream of Protein Kinase C Function 1173
Aljoscha Nern and
Robert A. Arkowitz A Cdc24p--Far1p--G$ \beta \gamma $
Protein Complex Required for Yeast
Orientation during Mating . . . . . . . 1187
M. Jamie T. V. Cope and
Shirley Yang and
Ching Shang and
David G. Drubin Novel Protein Kinases Ark1p and Prk1p
Associate with and Regulate the Cortical
Actin Cytoskeleton in Budding Yeast . . 1203
Brendan D. Manning and
Jennifer G. Barrett and
Julie A. Wallace and
Howard Granok and
Michael Snyder Differential Regulation of the Kar3p
Kinesin-related Protein by Two
Associated Proteins, Cik1p and Vik1p . . 1219
Catherine D. Nobes and
Alan Hall Rho GTPases Control Polarity,
Protrusion, and Adhesion during Cell
Movement . . . . . . . . . . . . . . . . 1235
Valérie Laurent and
Thomas P. Loisel and
Birgit Harbeck and
Ann Wehman and
Lothar Gröbe and
Brigitte M. Jockusch and
Jürgen Wehland and
Frank B. Gertler and
Marie-France Carlier Role of Proteins of the Ena/VASP Family
in Actin-based Motility of
\bioname\bionameListeria monocytogenes 1245
McRae W. Williams and
Robert J. Bloch Extensive but Coordinated Reorganization
of the Membrane Skeleton in Myofibers of
Dystrophic (mdx) Mice . . . . . . . . . 1259
Sushmita Mukherjee and
Thwe Thwe Soe and
Frederick R. Maxfield Endocytic Sorting of Lipid Analogues
Differing Solely in the Chemistry of
Their Hydrophobic Tails . . . . . . . . 1271
Ying Wei and
Xiuwei Yang and
Qiumei Liu and
John A. Wilkins and
Harold A. Chapman A Role for Caveolin and the Urokinase
Receptor in Integrin-mediated Adhesion
and Signaling . . . . . . . . . . . . . 1285
Sarita K. Sastry and
Margot Lakonishok and
Stanley Wu and
Tho Q. Truong and
Anna Huttenlocher and
Christopher E. Turner and
Alan F. Horwitz Quantitative Changes in Integrin and
Focal Adhesion Signaling Regulate
Myoblast Cell Cycle Withdrawal . . . . . 1295
Yuzo Imamura and
Masahiko Itoh and
Yoshito Maeno and
Shoichiro Tsukita and
Akira Nagafuchi Functional Domains of $ \alpha $-Catenin
Required for the Strong State of
Cadherin-based Cell Adhesion . . . . . . 1311
Susan M. Burden-Gulley and
Susann M. Brady-Kalnay PTP$ \mu $ Regulates
N--Cadherin-dependent Neurite Outgrowth 1323
Nadia Farrelly and
Yi-Ju Lee and
Janine Oliver and
Caroline Dive and
Charles H. Streuli Extracellular Matrix Regulates Apoptosis
in Mammary Epithelium through a Control
on Insulin Signaling . . . . . . . . . . 1337
Guoping Feng and
Eric Krejci and
Jordi Molgo and
Jeanette M. Cunningham and
Jean Massoulié and
Joshua R. Sanes Genetic Analysis of Collagen Q: Roles in
Acetylcholinesterase and
Butyrylcholinesterase Assembly and in
Synaptic Structure and Function . . . . 1349
David C. Allison and
Andrea L. Nestor Evidence for a Relatively Random Array
of Human Chromosomes on the Mitotic Ring 1
Katherine M. Hyland and
Jeffrey Kingsbury and
Doug Koshland and
Philip Hieter Ctf19p: a Novel Kinetochore Protein in
\bionameSaccharomyces cerevisiae and a
Potential Link between the Kinetochore
and Mitotic Spindle . . . . . . . . . . 15
Subhendra N. Mattagajasingh and
Shu-Ching Huang and
Julia S. Hartenstein and
Michael Snyder and
Vincent T. Marchesi and
Edward J. Benz A Nonerythroid Isoform of Protein 4.1R
Interacts with the Nuclear Mitotic
Apparatus (NuMA) Protein . . . . . . . . 29
Michael Kann and
Beate Sodeik and
Angelika Vlachou and
Wolfram H. Gerlich and
Ari Helenius Phosphorylation-dependent Binding of
Hepatitis B Virus Core Particles to the
Nuclear Pore Complex . . . . . . . . . . 45
Arielle R. Rosenberg and
Lélia Delamarre and
Claudine Pique and
Isabelle Le Blanc and
Graziella Griffith and
Marie-Christine Dokhélar Early Assembly Step of a Retroviral
Envelope Glycoprotein: Analysis Using a
Dominant Negative Assay . . . . . . . . 57
Olivia W. Rossanese and
Jon Soderholm and
Brooke J. Bevis and
Irina B. Sears and
James O'Connor and
Edward K. Williamson and
Benjamin S. Glick Golgi Structure Correlates with
Transitional Endoplasmic Reticulum
Organization in Pichia pastoris and
\bionameSaccharomyces cerevisiae . . . . 69
Carlos Infante and
Francisco Ramos-Morales and
Concepción Fedriani and
Michel Bornens and
Rosa M. Rios GMAP-210, a cis-Golgi network-associated
protein, is a minus end
microtubule-binding protein . . . . . . 83
Jiandi Zhang and
Mary C. Reedy and
Yusuf A. Hannun and
Lina M. Obeid Inhibition of Caspases Inhibits the
Release of Apoptotic Bodies: Bcl-2
Inhibits the Initiation of Formation of
Apoptotic Bodies in Chemotherapeutic
Agent-induced Apoptosis . . . . . . . . 99
Steven R. Heidemann and
Stefanie Kaech and
Robert E. Buxbaum and
Andrew Matus Direct Observations of the Mechanical
Behaviors of the Cytoskeleton in Living
Fibroblasts . . . . . . . . . . . . . . 109
David R. Sheff and
Elizabeth A. Daro and
Michael Hull and
Ira Mellman The Receptor Recycling Pathway Contains
Two Distinct Populations of Early
Endosomes with Different Sorting
Functions . . . . . . . . . . . . . . . 123
Rosa Puertollano and
Fernando Martín-Belmonte and
Jaime Millán and
María del Carmen de Marco and
Juan P. Albar and
Leonor Kremer and
Miguel A. Alonso The MAL Proteolipid Is Necessary for
Normal Apical Transport and Accurate
Sorting of the Influenza Virus
Hemagglutinin in Madin--Darby Canine
Kidney Cells . . . . . . . . . . . . . . 141
Rachelle H. Crosbie and
Connie S. Lebakken and
Kathleen H. Holt and
David P. Venzke and
Volker Straub and
Jane C. Lee and
R. Mark Grady and
Jeffery S. Chamberlain and
Joshua R. Sanes and
Kevin P. Campbell Membrane Targeting and Stabilization of
Sarcospan Is Mediated by the Sarcoglycan
Subcomplex . . . . . . . . . . . . . . . 153
Iakowos Karakesisoglou and
Klaus-Peter Janssen and
Ludwig Eichinger and
Angelika A. Noegel and
Michael Schleicher Identification of a Suppressor of the
Dictyostelium Profilin-minus Phenotype
as a CD36/LIMP--II Homologue . . . . . . 167
S. J. Millward-Sadler and
M. O. Wright and
H.-S. Lee and
K. Nishida and
H. Caldwell and
G. Nuki and
D. M. Salter Integrin-regulated Secretion of
Interleukin 4: a Novel Pathway of
Mechanotransduction in Human Articular
Chondrocytes . . . . . . . . . . . . . . 183
Doris Martin and
Susan Zusman and
Xitong Li and
Erin L. Williams and
Narmada Khare and
Sol DaRocha and
Ruth Chiquet-Ehrismann and
Stefan Baumgartner wing blister, A New \bionameDrosophila
Laminin $ \alpha $ Chain Required for
Cell Adhesion and Migration during
Embryonic and Imaginal Development . . . 191
Christopher D. Smith and
Elizabeth H. Blackburn Uncapping and Deregulation of Telomeres
Lead to Detrimental Cellular
Consequences in Yeast . . . . . . . . . 203
Bahram Houchmandzadeh and
Stefan Dimitrov Elasticity Measurements Show the
Existence of Thin Rigid Cores Inside
Mitotic Chromosomes . . . . . . . . . . 215
Debra M. Sauvé and
Hilary J. Anderson and
Jill M. Ray and
William M. James and
Michel Roberge Phosphorylation-induced Rearrangement of
the Histone H3 NH$_2$-terminal Domain
during Mitotic Chromosome Condensation 225
Colin E. J. Pritchard and
Maarten Fornerod and
Lawryn H. Kasper and
Jan M. A. van Deursen RAE1 Is a Shuttling mRNA Export Factor
That Binds to a GLEBS-like NUP98 Motif
at the Nuclear Pore Complex through
Multiple Domains . . . . . . . . . . . . 237
Efrosyni Paraskeva and
Elisa Izaurralde and
F. Ralf Bischoff and
Jochen Huber and
Ulrike Kutay and
Enno Hartmann and
Reinhard Lührmann and
Dirk Görlich CRM1-mediated Recycling of Snurportin 1
to the Cytoplasm . . . . . . . . . . . . 255
William J. Hansen and
Nicholas J. Cowan and
William J. Welch Prefoldin--Nascent Chain Complexes in
the Folding of Cytoskeletal Proteins . . 265
Ping Lin and
Yong Yao and
Robert Hofmeister and
Roger Y. Tsien and
Marilyn Gist Farquhar Overexpression of CALNUC (Nucleobindin)
Increases Agonist and Thapsigargin
Releasable Ca$^{2+}$ Storage in the
Golgi . . . . . . . . . . . . . . . . . 279
Shelly Meeusen and
Quinton Tieu and
Edith Wong and
Eric Weiss and
David Schieltz and
John R. Yates and
Jodi Nunnari Mgm101p Is a Novel Component of the
Mitochondrial Nucleoid That Binds DNA
and Is Required for the Repair of
Oxidatively Damaged Mitochondrial DNA 291
Fridoon J. Ahmad and
Wenqian Yu and
Francis J. McNally and
Peter W. Baas An Essential Role for Katanin in
Severing Microtubules in the Neuron . . 305
Benedikt Kost and
Emmanuel Lemichez and
Pius Spielhofer and
Yan Hong and
Kimberly Tolias and
Christopher Carpenter and
Nam-Hai Chua Rac Homologues and Compartmentalized
Phosphatidylinositol 4, 5-Bisphosphate
Act in a Common Pathway to Regulate
Polar Pollen Tube Growth . . . . . . . . 317
Maryse Bailly and
Frank Macaluso and
Michael Cammer and
Amanda Chan and
Jeffrey E. Segall and
John S. Condeelis Relationship between Arp2/3 Complex and
the Barbed Ends of Actin Filaments at
the Leading Edge of Carcinoma Cells
after Epidermal Growth Factor
Stimulation . . . . . . . . . . . . . . 331
Yuko Fukata and
Noriko Oshiro and
Nagatoki Kinoshita and
Yoji Kawano and
Yoichiro Matsuoka and
Vann Bennett and
Yoshiharu Matsuura and
Kozo Kaibuchi Phosphorylation of Adducin by
Rho--Kinase Plays a Crucial Role in Cell
Motility . . . . . . . . . . . . . . . . 347
Patrick G. Bray and
Omar Janneh and
Kaylene J. Raynes and
Mathirut Mungthin and
Hagai Ginsburg and
Stephen A. Ward Cellular Uptake of Chloroquine Is
Dependent on Binding to
Ferriprotoporphyrin IX and Is
Independent of NHE Activity in
Plasmodium falciparum . . . . . . . . . 363
Woutervan't Hof and
Marilyn D. Resh Dual Fatty Acylation of p59 $^{\rm Fyn}$
Is Required for Association with the T
Cell Receptor $ \zeta $ Chain through
Phosphotyrosine--Src Homology Domain-2
Interactions . . . . . . . . . . . . . . 377
Amy M. Kachinsky and
Stanley C. Froehner and
Sharon L. Milgram A PDZ-containing Scaffold Related to the
Dystrophin Complex at the Basolateral
Membrane of Epithelial Cells . . . . . . 391
Anuska V. Andjelkovic and
Dennis D. Spencer and
Joel S. Pachter Visualization of Chemokine Binding Sites
on Human Brain Microvessels . . . . . . 403
Yasuyuki Taooka and
John Chen and
Ted Yednock and
Dean Sheppard The Integrin $ \alpha $9$ \beta $1
Mediates Adhesion to Activated
Endothelial Cells and Transendothelial
Neutrophil Migration through Interaction
with Vascular Cell Adhesion Molecule-1 413
Margit Keresztes and
Johannes Boonstra Import(ance) of Growth Factors in(to)
the Nucleus . . . . . . . . . . . . . . 421
Hong-Guo Yu and
Michael G. Muszynski and
R. Kelly Dawe The Maize Homologue of the Cell Cycle
Checkpoint Protein MAD2 Reveals
Kinetochore Substructure and Contrasting
Mitotic and Meiotic Localization
Patterns . . . . . . . . . . . . . . . . 425
Rumi Yamaguchi and
Masanobu Nakamura and
Nobuyoshi Mochizuki and
Steve A. Kay and
Akira Nagatani Light-dependent Translocation of a
Phytochrome B--GFP Fusion Protein to the
Nucleus in Transgenic Arabidopsis . . . 437
Joanne M. Yeakley and
Hél\`ene Tronch\`ere and
James Olesen and
Jacqueline A. Dyck and
Huan-You Wang and
Xiang-Dong Fu Phosphorylation Regulates In Vivo
Interaction and Molecular Targeting of
Serine/Arginine-rich Pre-mRNA Splicing
Factors . . . . . . . . . . . . . . . . 447
Marie-José J. E. Bijlmakers and
Mark Marsh Trafficking of an Acylated Cytosolic
Protein: Newly Synthesized p56 $^{\rm
lck}$ Travels to the Plasma Membrane via
the Exocytic Pathway . . . . . . . . . . 457
Joseph R. Marszalek and
Joshua A. Weiner and
Samuel J. Farlow and
Jerold Chun and
Lawrence S. B. Goldstein Novel Dendritic Kinesin Sorting
Identified by Different Process
Targeting of Two Related Kinesins:
KIF21A and KIF21B . . . . . . . . . . . 469
W. Christian Wigley and
Rosalind P. Fabunmi and
Min Goo Lee and
Christopher R. Marino and
Shmuel Muallem and
George N. DeMartino and
Philip J. Thomas Dynamic Association of Proteasomal
Machinery with the Centrosome . . . . . 481
Shoichiro Ono and
David L. Baillie and
Guy M. Benian UNC-60B, an ADF/Cofilin Family Protein,
Is Required for Proper Assembly of Actin
into Myofibrils in
\bionameCaenorhabditis elegans Body Wall
Muscle . . . . . . . . . . . . . . . . . 491
Milos Pekny and
Clas B. Johansson and
Camilla Eliasson and
Josefina Stakeberg and
Åsa Wallén and
Thomas Perlmann and
Urban Lendahl and
Christer Betsholtz and
Claes-Henric Berthold and
Jonas Frisén Abnormal Reaction to Central Nervous
System Injury in Mice Lacking Glial
Fibrillary Acidic Protein and Vimentin 503
Elisa M. Miguélez and
Carlos Hardisson and
Manuel B. Manzanal Hyphal Death during Colony Development
in \bionameStreptomyces antibioticus:
Morphological Evidence for the Existence
of a Process of Cell Deletion in a
Multicellular Prokaryote . . . . . . . . 515
Teresa L. Burgess and
Yi-xin Qian and
Stephen Kaufman and
Brian D. Ring and
Gwyneth Van and
Charles Capparelli and
Michael Kelley and
Hailing Hsu and
William J. Boyle and
Colin R. Dunstan and
Sylvia Hu and
David L. Lacey The Ligand for Osteoprotegerin (OPGL)
Directly Activates Mature Osteoclasts 527
Kenichi Takahashi and
Hiroyuki Nakanishi and
Masako Miyahara and
Kenji Mandai and
Keiko Satoh and
Ayako Satoh and
Hideo Nishioka and
Junken Aoki and
Akio Nomoto and
Akira Mizoguchi and
Yoshimi Takai Nectin/PRR: an Immunoglobulin-like Cell
Adhesion Molecule Recruited to
Cadherin-based Adherens Junctions
through Interaction with Afadin, a PDZ
Domain--containing Protein . . . . . . . 539
Shinya Aono and
Shinichi Nakagawa and
Albert B. Reynolds and
Masatoshi Takeichi p120$^{\rm ctn}$ Acts as an Inhibitory
Regulator of Cadherin Function in Colon
Carcinoma Cells . . . . . . . . . . . . 551
Toshitaka Oohashi and
Xiao-Hong Zhou and
Kang Feng and
Brigitta Richter and
Matthias Mörgelin and
Maria Thereza Perez and
Wei-Dong Su and
Ruth Chiquet-Ehrismann and
Uwe Rauch and
Reinhard Fässler Mouse Ten-m/Odz Is a New Family of
Dimeric Type II Transmembrane Proteins
Expressed in Many Tissues . . . . . . . 563
Kazumasa Morita and
Hiroyuki Sasaki and
Kazushi Fujimoto and
Mikio Furuse and
Shoichiro Tsukita Claudin-11\slash OSP-based Tight
Junctions of Myelin Sheaths in Brain and
Sertoli Cells in Testis . . . . . . . . 579
Tim Oliver and
Micah Dembo and
Ken Jacobson Separation of Propulsive and Adhesive
Traction Stresses in Locomoting
Keratocytes . . . . . . . . . . . . . . 589
Manuel Koch and
Pamela F. Olson and
Anne Albus and
William Jin and
Dale D. Hunter and
William J. Brunken and
Robert E. Burgeson and
Marie-France Champliaud Characterization and Expression of the
Laminin $ \gamma $3 Chain: A Novel,
Non-Basement Membrane-associated,
Laminin Chain . . . . . . . . . . . . . 605
Holly Colognato and
Donald A. Winkelmann and
Peter D. Yurchenco Laminin Polymerization Induces a
Receptor--Cytoskeleton Network . . . . . 619
Simon M. Hughes and
Maggie M.-Y. Chi and
Oliver H. Lowry and
Kristian Gundersen Myogenin Induces a Shift of Enzyme
Activity from Glycolytic to Oxidative
Metabolism in Muscles of Transgenic Mice 633
Ralph H. Kehlenbach and
Achim Dickmanns and
Angelika Kehlenbach and
Tinglu Guan and
Larry Gerace A Role for RanBP1 in the Release of CRM1
from the Nuclear Pore Complex in a
Terminal Step of Nuclear Export . . . . 645
Kevin J. Roberg and
Michelle Crotwell and
Peter Espenshade and
Ruth Gimeno and
Chris A. Kaiser LST1 Is a SEC24 Homologue Used for
Selective Export of the Plasma Membrane
ATPase from the Endoplasmic Reticulum 659
Michel Dominguez and
Ali Fazel and
Sophie Dahan and
Jacque Lovell and
Louis Hermo and
Alejandro Claude and
Paul Melançon and
J. J. M. Bergeron Fusogenic Domains of Golgi Membranes Are
Sequestered into Specialized Regions of
the Stack that Can Be Released by
Mechanical Fragmentation . . . . . . . . 673
Wandy L. Beatty and
Stéphane Méresse and
Pierre Gounon and
Jean Davoust and
Joëlle Mounier and
Philippe J. Sansonetti and
Jean-Pierre Gorvel Trafficking of Shigella
Lipopolysaccharide in Polarized
Intestinal Epithelial Cells . . . . . . 689
Nicole R. Murray and
Laurie A. Davidson and
Robert S. Chapkin and
W. Clay Gustafson and
Diane G. Schattenberg and
Alan P. Fields Overexpression of Protein Kinase C $
\beta_{II} $ Induces Colonic
Hyperproliferation and Increased
Sensitivity to Colon Carcinogenesis . . 699
Ruth Zeidman and
Bjarne Löfgren and
Sven Påhlman and
Christer Larsson PKC$ \epsilon $, Via its Regulatory
Domain and Independently of its
Catalytic Domain, Induces Neurite-like
Processes in Neuroblastoma Cells . . . . 713
Ken'ichiro Hayashi and
Masanori Takahashi and
Kazuhiro Kimura and
Wataru Nishida and
Hiroshi Saga and
Kenji Sobue Changes in the Balance of
Phosphoinositide 3-Kinase/Protein Kinase
B (Akt) and the Mitogen-activated
Protein Kinases (ERK/p38MAPK) Determine
a Phenotype of Visceral and Vascular
Smooth Muscle Cells . . . . . . . . . . 727
François Fagotto and
Eek-hoon Jho and
Li Zeng and
Thomas Kurth and
Thomas Joos and
Christine Kaufmann and
Frank Costantini Domains of Axin Involved in
Protein--Protein Interactions, Wnt
Pathway Inhibition, and Intracellular
Localization . . . . . . . . . . . . . . 741
Frank Madeo and
Eleonore Fröhlich and
Martin Ligr and
Martin Grey and
Stephan J. Sigrist and
Dieter H. Wolf and
Kai-Uwe Fröhlich Oxygen Stress: a Regulator of Apoptosis
in Yeast . . . . . . . . . . . . . . . . 757
Graziella Pellegrini and
Osvaldo Golisano and
Patrizia Paterna and
Alessandro Lambiase and
Stefano Bonini and
Paolo Rama and
Michele De Luca Location and Clonal Analysis of Stem
Cells and Their Differentiated Progeny
in the Human Ocular Surface . . . . . . 769
Rosa Serra and
Andrew Karaplis and
Philip Sohn Parathyroid Hormone--related Peptide
(PTHrP)-dependent and -independent
Effects of Transforming Growth Factor $
\beta $ (TGF-$ \beta $) on Endochondral
Bone Formation . . . . . . . . . . . . . 783
Eric Boitier and
Ruth Rea and
Michael R. Duchen Mitochondria Exert a Negative Feedback
on the Propagation of Intracellular
Ca$^{2+}$ Waves in Rat Cortical
Astrocytes . . . . . . . . . . . . . . . 795
Ian R. Adams and
John V. Kilmartin Localization of Core Spindle Pole Body
(SPB) Components during SPB Duplication
in \bionameSaccharomyces cerevisiae . . 809
Sen Takeda and
Yoshiaki Yonekawa and
Yosuke Tanaka and
Yasushi Okada and
Shigenori Nonaka and
Nobutaka Hirokawa Left-Right Asymmetry and Kinesin
Superfamily Protein KIF3A: New Insights
in Determination of Laterality and
Mesoderm Induction by kif3A$^- / - $
Mice Analysis . . . . . . . . . . . . . 825
Mary Ann Sells and
Jonathan T. Boyd and
Jonathan Chernoff p21-Activated Kinase 1 (Pak1) Regulates
Cell Motility in Mammalian Fibroblasts 837
Christopher E. Turner and
Michael C. Brown and
Joseph A. Perrotta and
M. C. Riedy and
Sotiris N. Nikolopoulos and
A. Rosa McDonald and
Shubha Bagrodia and
Sheila Thomas and
Phillip S. Leventhal Paxillin LD4 Motif Binds PAK and PIX
through a Novel 95-kD Ankyrin Repeat,
ARF--GAP Protein: a Role in Cytoskeletal
Remodeling . . . . . . . . . . . . . . . 851
Andreas Marg and
Pinar Sirim and
Frank Spaltmann and
Antonius Plagge and
Gunther Kauselmann and
Friedrich Buck and
Fritz G. Rathjen and
Thomas Brümmendorf Neurotractin, A Novel Neurite
Outgrowth-promoting Ig-like Protein that
Interacts with CEPU-1 and LAMP . . . . . 865
Erin D. Sheets and
David Holowka and
Barbara Baird Critical Role for Cholesterol in
Lyn-mediated Tyrosine Phosphorylation of
Fc$ \epsilon $RI and Their Association
with Detergent-resistant Membranes . . . 877
Scott D. Blystone and
Suzanne E. Slater and
Matthew P. Williams and
Michael T. Crow and
Eric J. Brown A Molecular Mechanism of Integrin
Crosstalk: $ \alpha_v \beta_3 $
Suppression of
Calcium/Calmodulin-dependent Protein
Kinase II Regulates $ \alpha_5 \beta_1 $
Function . . . . . . . . . . . . . . . . 889
Annette Bistrup and
Sunil Bhakta and
Jin Kyu Lee and
Yevgeniy Y. Belov and
Michael Dee Gunn and
Feng-Rong Zuo and
Chiao-Chain Huang and
Reiji Kannagi and
Steven D. Rosen and
Stefan Hemmerich Sulfotransferases of Two Specificities
Function in the Reconstitution of High
Endothelial Cell Ligands for L-selectin 899
H. Benjamin Peng and
Hongbo Xie and
Susanna G. Rossi and
Richard L. Rotundo Acetylcholinesterase Clustering at the
Neuromuscular Junction Involves Perlecan
and Dystroglycan . . . . . . . . . . . . 911
Juan S. Bonifacino and
Esteban C. Dell'Angelica Molecular Bases for the Recognition of
Tyrosine-based Sorting Signals . . . . . 923
Randy A. Hall and
Richard T. Premont and
Robert J. Lefkowitz Heptahelical Receptor Signaling: Beyond
the G Protein Paradigm . . . . . . . . . 927
Iain D. Russell and
Adam S. Grancell and
Peter K. Sorger The Unstable F-box Protein p58-Ctf13
Forms the Structural Core of the CBF3
Kinetochore Complex . . . . . . . . . . 933
Lily Jun-shen Huang and
Lin Wang and
Yuliang Ma and
Kyle Durick and
Guy Perkins and
Thomas J. Deerinck and
Mark H. Ellisman and
Susan S. Taylor NH$_2$ -Terminal Targeting Motifs Direct
Dual Specificity A--Kinase--anchoring
Protein 1 (D--AKAP1) to Either
Mitochondria or Endoplasmic Reticulum 951
Alessio Merlin and
Wolfgang Voos and
Ammy C. Maarse and
Michiel Meijer and
Nikolaus Pfanner and
Joachim Rassow The J-related Segment of Tim44 Is
Essential for Cell Viability: a Mutant
Tim44 Remains in the Mitochondrial
Import Site, but Inefficiently Recruits
mtHsp70 and Impairs Protein
Translocation . . . . . . . . . . . . . 961
Enrico Schleiff and
John R. Silvius and
Gordon C. Shore Direct Membrane Insertion of
Voltage-dependent Anion-selective
Channel Protein Catalyzed by
Mitochondrial Tom20 . . . . . . . . . . 973
Roberta Fraschini and
Elisa Formenti and
Giovanna Lucchini and
Simonetta Piatti Budding Yeast Bub2 Is Localized at
Spindle Pole Bodies and Activates the
Mitotic Checkpoint via a Different
Pathway from Mad2 . . . . . . . . . . . 979
Jennifer S. Tirnauer and
Eileen O'Toole and
Lisbeth Berrueta and
Barbara E. Bierer and
David Pellman Yeast Bim1p Promotes the G1-specific
Dynamics of Microtubules . . . . . . . . 993
Tatyana M. Svitkina and
Gary G. Borisy Arp2/3 Complex and Actin Depolymerizing
Factor/Cofilin in Dendritic Organization
and Treadmilling of Actin Filament Array
in \bionameLamellipodia . . . . . . . . 1009
Antonella Tripiciano and
Carmelina Peluso and
Anna Rita Morena and
Fioretta Palombi and
Mario Stefanini and
Elio Ziparo and
Masashi Yanagisawa and
Antonio Filippini Cyclic Expression of
Endothelin-converting Enzyme-1 Mediates
the Functional Regulation of
Seminiferous Tubule Contraction . . . . 1027
Sumio Terada and
Tetsuhiro Tsujimoto and
Yosuke Takei and
Tomoyuki Takahashi and
Nobutaka Hirokawa Impairment of Inhibitory Synaptic
Transmission in Mice Lacking Synapsin I 1039
Robert Eferl and
Maria Sibilia and
Frank Hilberg and
Andrea Fuchsbichler and
Iris Kufferath and
Barbara Guertl and
Rainer Zenz and
Erwin F. Wagner and
Kurt Zatloukal Functions of c--Jun in Liver and Heart
Development . . . . . . . . . . . . . . 1049
F. Frémion and
M. Astier and
S. Zaffran and
A. Guill\`en and
V. Homburger and
M. Sémériva The Heterotrimeric Protein G$_o$ Is
Required for the Formation of Heart
Epithelium in \bionameDrosophila . . . . 1063
Patricia J. Keely and
Elena V. Rusyn and
Adrienne D. Cox and
Leslie V. Parise R-Ras Signals through Specific Integrin
$ \alpha $ Cytoplasmic Domains to
Promote Migration and Invasion of Breast
Epithelial Cells . . . . . . . . . . . . 1077
Pamela L. Tuma and
Catherine M. Finnegan and
Ji-Hyun Yi and
Ann L. Hubbard Evidence for Apical Endocytosis in
Polarized Hepatic Cells:
Phosphoinositide 3-Kinase Inhibitors
Lead to the Lysosomal Accumulation of
Resident Apical Plasma Membrane Proteins 1089
M. M. French and
S. E. Smith and
K. Akanbi and
T. Sanford and
J. Hecht and
M. C. Farach-Carson and
D. D. Carson Expression of the Heparan Sulfate
Proteoglycan, Perlecan, during Mouse
Embryogenesis and Perlecan Chondrogenic
Activity In Vitro . . . . . . . . . . . 1103
Jenny A. Croft and
Joanna M. Bridger and
Shelagh Boyle and
Paul Perry and
Peter Teague and
Wendy A. Bickmore Differences in the Localization and
Morphology of Chromosomes in the Human
Nucleus . . . . . . . . . . . . . . . . 1119
Caroline Jolly and
Claire Vourc'h and
Michel Robert-Nicoud and
Richard I. Morimoto Intron-independent Association of
Splicing Factors with Active Genes . . . 1133
Naoyuki Kataoka and
Jennifer L. Bachorik and
Gideon Dreyfuss Transportin-SR, a Nuclear Import
Receptor for SR Proteins . . . . . . . . 1145
Jose A. Trilla and
Angel Durán and
Cesar Roncero Chs7p, a New Protein Involved in the
Control of Protein Export from the
Endoplasmic Reticulum that Is
Specifically Engaged in the Regulation
of Chitin Synthesis in
\bionameSaccharomyces cerevisiae . . . . 1153
Chenhui Wen and
Iva Greenwald p24 Proteins and Quality Control of
LIN-12 and GLP-1 Trafficking in
\bionameCaenorhabditis elegans . . . . . 1165
Sylvia L. Sanders and
Martina Gentzsch and
Widmar Tanner and
Ira Herskowitz O-Glycosylation of Axl2/Bud10p by Pmt4p
Is Required for Its Stability,
Localization, and Function in Daughter
Cells . . . . . . . . . . . . . . . . . 1177
Radu-Virgil Stan and
Lucian Ghitescu and
Bruce S. Jacobson and
George E. Palade Isolation, Cloning, and Localization of
Rat PV-1, a Novel Endothelial Caveolar
Protein . . . . . . . . . . . . . . . . 1189
Harold A. Fisk and
Michael P. Yaffe A Role for Ubiquitination in
Mitochondrial Inheritance in
\bionameSaccharomyces cerevisiae . . . . 1199
Donna J. Osterhout and
Amy Wolven and
Rebecca M. Wolf and
Marilyn D. Resh and
Moses V. Chao Morphological Differentiation of
Oligodendrocytes Requires Activation of
Fyn Tyrosine Kinase . . . . . . . . . . 1209
Miguel A. Gijón and
Diane M. Spencer and
Alan L. Kaiser and
Christina C. Leslie Role of Phosphorylation Sites and the C2
Domain in Regulation of Cytosolic
Phospholipase A$_2$ . . . . . . . . . . 1219
Ayumu Yamamoto and
Robert R. West and
J. Richard McIntosh and
Yasushi Hiraoka A Cytoplasmic Dynein Heavy Chain Is
Required for Oscillatory Nuclear
Movement of Meiotic Prophase and
Efficient Meiotic Recombination in
Fission Yeast . . . . . . . . . . . . . 1233
Avital A. Rodal and
Jonathan W. Tetreault and
Pekka Lappalainen and
David G. Drubin and
David C. Amberg Aip1p Interacts with Cofilin to
Disassemble Actin Filaments . . . . . . 1251
Pak-ming Lau and
Robert S. Zucker and
David Bentley Induction of Filopodia by Direct Local
Elevation of Intracellular Calcium Ion
Concentration . . . . . . . . . . . . . 1265
Stacy M. Stabler and
Lisa L. Ostrowski and
Susan M. Janicki and
Mervyn J. Monteiro A Myristoylated Calcium-binding Protein
that Preferentially Interacts with the
Alzheimer's Disease Presenilin 2 Protein 1277
Beata Wójciak-Stothard and
Lynn Williams and
Anne J. Ridley Monocyte Adhesion and Spreading on Human
Endothelial Cells Is Dependent on
Rho-regulated Receptor Clustering . . . 1293
Maureen C. Ryan and
Keesook Lee and
Yuko Miyashita and
William G. Carter Targeted Disruption of the LAMA3 Gene in
Mice Reveals Abnormalities in Survival
and Late Stage Differentiation of
Epithelial Cells . . . . . . . . . . . . 1309
Federica Montanaro and
Michael Lindenbaum and
Salvatore Carbonetto $ \alpha $-Dystroglycan Is a Laminin
Receptor Involved in Extracellular
Matrix Assembly on Myotubes and Muscle
Cell Viability . . . . . . . . . . . . . 1325
Tudorita Tumbar and
Gail Sudlow and
Andrew S. Belmont Large-Scale Chromatin Unfolding and
Remodeling Induced by VP16 Acidic
Activation Domain . . . . . . . . . . . 1341
Angela Krämer and
Patric Grüter and
Karsten Gröning and
Berthold Kastner Combined Biochemical and Electron
Microscopic Analyses Reveal the
Architecture of the Mammalian U2 snRNP 1355
Anne-Marie Dechampesme and
Olga Koroleva and
Isabelle Leger-Silvestre and
Nicole Gas and
Sylvie Camier Assembly of 5S Ribosomal RNA Is Required
at a Specific Step of the Pre-rRNA
Processing Pathway . . . . . . . . . . . 1369
Jae-hyun Kim and
Jung-seog Kang and
Clarence S. M. Chan Sli15 Associates with the Ipl1 Protein
Kinase to Promote Proper Chromosome
Segregation in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 1381
Linda M. Woods and
Craig A. Hodges and
Esther Baart and
Sean M. Baker and
Michael Liskay and
Patricia A. Hunt Chromosomal Influence on Meiotic Spindle
Assembly: Abnormal Meiosis I in Female
Mlh1 Mutant Mice . . . . . . . . . . . . 1395
Lucy F. Pemberton and
Jonathan S. Rosenblum and
Günter Blobel Nuclear Import of the TATA-binding
Protein: Mediation by the Karyopherin
Kap114p and a Possible Mechanism for
Intranuclear Targeting . . . . . . . . . 1407
Anastasiya D. Blagoveshchenskaya and
Eric W. Hewitt and
Daniel F. Cutler A Complex Web of Signal-dependent
Trafficking Underlies the Triorganellar
Distribution of P--Selectin in
Neuroendocrine PC12 Cells . . . . . . . 1419
Christian Ungermann and
Gabriele Fischer von Mollard and
Ole N. Jensen and
Nathan Margolis and
Tom H. Stevens and
William Wickner Three v--SNAREs and Two t--SNAREs,
Present in a Pentameric cis--SNARE
Complex on Isolated Vacuoles, Are
Essential for Homotypic Fusion . . . . . 1435
Robert Luetterforst and
Espen Stang and
Natasha Zorzi and
Amanda Carozzi and
Michael Way and
Robert G. Parton Molecular Characterization of Caveolin
Association with the Golgi Complex:
Identification of a cis-Golgi Targeting
Domain in the Caveolin Molecule . . . . 1443
Maja Oktay and
Kishore K. Wary and
Michael Dans and
Raymond B. Birge and
Filippo G. Giancotti Integrin-mediated Activation of Focal
Adhesion Kinase Is Required for
Signaling to Jun NH$_2$-terminal Kinase
and Progression through the G1 Phase of
the Cell Cycle . . . . . . . . . . . . . 1461
Karen Heyninck and
Dirk De Valck and
Wim Vanden Berghe and
Wim Van Criekinge and
Roland Contreras and
Walter Fiers and
Guy Haegeman and
Rudi Beyaert The Zinc Finger Protein A20 Inhibits
TNF-induced NF-$ \kappa $B-dependent
Gene Expression by Interfering with an
RIP- or TRAF2-mediated Transactivation
Signal and Directly Binds to a Novel
NF-$ \kappa $B-inhibiting Protein ABIN 1471
Daniel E. Michele and
Faris P. Albayya and
Joseph M. Metzger Thin Filament Protein Dynamics in Fully
Differentiated Adult Cardiac Myocytes:
Toward A Model of Sarcomere Maintenance 1483
Shigenobu Yonemura and
Sachiko Tsukita and
Shoichiro Tsukita Direct Involvement of
Ezrin/Radixin/Moesin (ERM)-binding
Membrane Proteins in the Organization of
Microvilli in Collaboration with
Activated ERM Proteins . . . . . . . . . 1497
Emmanuelle Astoul and
Sandra Watton and
Doreen Cantrell The Dynamics of Protein Kinase B
Regulation during B Cell Antigen
Receptor Engagement . . . . . . . . . . 1511
Alan W. Dove In Brief . . . . . . . . . . . . . . . . 0
Stéphane Brunet and
Angélica Santa Maria and
Philippe Guillaud and
Denis Dujardin and
Jacek Z. Kubiak and
Bernard Maro Kinetochore Fibers Are Not Involved in
the Formation of the First Meiotic
Spindle in Mouse Oocytes, but Control
the Exit from the First Meiotic M Phase 1
Joydeep Basu and
Hassan Bousbaa and
Elsa Logarinho and
ZeXiao Li and
Byron C. Williams and
Carla Lopes and
Claudio E. Sunkel and
Michael L. Goldberg Mutations in the Essential Spindle
Checkpoint Gene bub1 Cause Chromosome
Missegregation and Fail to Block
Apoptosis in \bionameDrosophila . . . . 13
Melissa M. Rolls and
Pascal A. Stein and
Stephen S. Taylor and
Edward Ha and
Frank McKeon and
Tom A. Rapoport A Visual Screen of a Gfp-Fusion Library
Identifies a New Type of Nuclear
Envelope Membrane Protein . . . . . . . 29
Hiroki Mori and
Elizabeth J. Summer and
Xianyue Ma and
Kenneth Cline Component Specificity for the
Thylakoidal Sec and Delta Ph-Dependent
Protein Transport Pathways . . . . . . . 45
James Shorter and
Graham Warren A Role for the Vesicle Tethering
Protein, P115, in the Post-Mitotic
Stacking of Reassembling Golgi Cisternae
in a Cell-Free System . . . . . . . . . 57
Alejandro Claude and
Bao-Ping Zhao and
Craig E. Kuziemsky and
Sophie Dahan and
Scott J. Berger and
Jian-Ping Yan and
Adrian D. Armold and
Eric M. Sullivan and
Paul Melançon Gbf1 . . . . . . . . . . . . . . . . . . 71
Thomas Vida and
Brenda Gerhardt A Cell-Free Assay Allows Reconstitution
of Vps33p-Dependent Transport to the
Yeast Vacuole/Lysosome . . . . . . . . . 85
Antonius Koller and
William B. Snyder and
Klaas Nico Faber and
Thibaut J. Wenzel and
Linda Rangell and
Gilbert A. Keller and
Suresh Subramani Pex22p of \bionamePichia pastoris,
Essential for Peroxisomal Matrix Protein
Import, Anchors the
Ubiquitin-Conjugating Enzyme, Pex4p, on
the Peroxisomal Membrane . . . . . . . . 99
Luis C. Antón and
Ulrich Schubert and
Igor Bacík and
Michael F. Princiotta and
Pamela A. Wearsch and
James Gibbs and
Patricia M. Day and
Claudio Realini and
Martin C. Rechsteiner and
Jack R. Bennink and
Jonathan W. Yewdell Intracellular Localization of
Proteasomal Degradation of a Viral
Antigen . . . . . . . . . . . . . . . . 113
Kevin Lehman and
Guendalina Rossi and
Joan E. Adamo and
Patrick Brennwald Yeast Homologues of Tomosyn and lethal
giant larvae Function in Exocytosis and
Are Associated with the Plasma Membrane
Snare, Sec9 . . . . . . . . . . . . . . 125
Ofer Cohen and
Boaz Inbal and
Joseph L. Kissil and
Tal Raveh and
Hanna Berissi and
Taly Spivak-Kroizaman and
Elena Feinstein and
Adi Kimchi Dap-Kinase Participates in TNF-$ \alpha
$-And FAS--Induced Apoptosis and Its
Function Requires the Death Domain . . . 141
Diem H. D. Nguyen and
Andrew D. Catling and
Donna J. Webb and
Mauricio Sankovic and
Lori A. Walker and
Avril V. Somlyo and
Michael J. Weber and
Steven L. Gonias Myosin Light Chain Kinase Functions
Downstream of Ras/ERK to Promote
Migration of Urokinase-Type Plasminogen
Activator-Stimulated Cells in an
Integrin--Selective Manner . . . . . . . 149
Aaron B. Bowman and
Ramila S. Patel-King and
Sharon E. Benashski and
J. Michael McCaffery and
Lawrence S. B. Goldstein and
Stephen M. King Drosophila roadblock and Chlamydomonas
Lc7 . . . . . . . . . . . . . . . . . . 165
Gregory A. Elder and
Victor L. Friedrich and
Alla Margita and
Robert A. Lazzarini Age-Related Atrophy of Motor Axons in
Mice Deficient in the Mid--Sized
Neurofilament Subunit . . . . . . . . . 181
Hiromi Terami and
Benjamin D. Williams and
Shin-ichi Kitamura and
Yasuji Sakube and
Shinji Matsumoto and
Shima Doi and
Takashi Obinata and
Hiroaki Kagawa Genomic Organization, Expression, and
Analysis of the Troponin C Gene pat-10
of \bionameCaenorhabditis elegans . . . 193
Sergey Rakhilin and
Renaldo C. Drisdel and
Daphna Sagher and
Daniel S. McGehee and
Yolanda Vallejo and
William N. Green $ \alpha $-Bungarotoxin Receptors
Contain $ \alpha $7 Subunits in Two
Different Disulfide--Bonded
Conformations . . . . . . . . . . . . . 203
Tam Luan Le and
Alpha S. Yap and
Jennifer L. Stow Recycling of E--Cadherin . . . . . . . . 219
Hua-Quan Miao and
Shay Soker and
Leonard Feiner and
José Luis Alonso and
Jonathan A. Raper and
Michael Klagsbrun Neuropilin-1 Mediates
Collapsin-1/Semaphorin III Inhibition of
Endothelial Cell Motility . . . . . . . 233
Hidenori Shiraha and
Angela Glading and
Kiran Gupta and
Alan Wells Ip-10 Inhibits Epidermal Growth
Factor--Induced Motility by Decreasing
Epidermal Growth Factor
Receptor--Mediated Calpain Activity . . 243
Danielle F. Cano-Gauci and
Howard H. Song and
Huiling Yang and
Colin McKerlie and
Barbara Choo and
Wen Shi and
Rose Pullano and
Tino D. Piscione and
Silviu Grisaru and
Shawn Soon and
Larisa Sedlackova and
A. Keith Tanswell and
Tak W. Mak and
Herman Yeger and
Gina A. Lockwood and
Norman D. Rosenblum and
Jorge Filmus Glypican-$3$--Deficient Mice Exhibit
Developmental Overgrowth and Some of the
Abnormalities Typical of
Simpson--Golabi--Behmel Syndrome . . . . 255
Laura M. Machesky and
Robert H. Insall Signaling to Actin Dynamics . . . . . . 267
Frank Becker and
Laura Block-Alper and
Gerald Nakamura and
Josephine Harada and
K. Dane Wittrup and
David I. Meyer Expression of the 180-kD Ribosome
Receptor Induces Membrane Proliferation
and Increased Secretory Activity in
Yeast . . . . . . . . . . . . . . . . . 273
C. Lavoie and
J. Paiement and
M. Dominguez and
L. Roy and
S. Dahan and
J. N. Gushue and
J. J. M. Bergeron Roles for $ \alpha_2 $ p24 and COPI in
Endoplasmic Reticulum Cargo Exit Site
Formation . . . . . . . . . . . . . . . 285
Lior Soussan and
Darya Burakov and
Mathew P. Daniels and
Mira Toister-Achituv and
Amir Porat and
Yossef Yarden and
Zvulun Elazar Erg30, a Vap-33--Related Protein,
Functions in Protein Transport Mediated
by Copi Vesicles . . . . . . . . . . . . 301
Jürgen H. Benting and
Anton G. Rietveld and
Kai Simons N-Glycans Mediate the Apical Sorting of
a Gpi--Anchored, Raft--Associated
Protein in Madin--Darby Canine Kidney
Cells . . . . . . . . . . . . . . . . . 313
Doron Rapaport and
Walter Neupert Biogenesis of Tom40, Core Component of
the Tom Complex of Mitochondria . . . . 321
Chavela M. Carr and
Eric Grote and
Mary Munson and
Frederick M. Hughson and
Peter J. Novick Sec1p Binds to SNARE Complexes and
Concentrates at Sites of Secretion . . . 333
William G. Mallet and
Frederick R. Maxfield Chimeric Forms of Furin and Tgn38 Are
Transported from the Plasma Membrane to
the Trans-Golgi Network via Distinct
Endosomal Pathways . . . . . . . . . . . 345
Kazunobu Sawamoto and
Per Winge and
Shinya Koyama and
Yuki Hirota and
Chiharu Yamada and
Sachiyo Miyao and
Shingo Yoshikawa and
Ming-hao Jin and
Akira Kikuchi and
Hideyuki Okano The \bionameDrosophila Ral GTPase
Regulates Developmental Cell Shape
Changes through the Jun NH$_2$-terminal
Kinase Pathway . . . . . . . . . . . . . 361
Jana Drgonová and
Tomás Drgon and
Dong-Hyun Roh and
Enrico Cabib The GTP-binding Protein Rho1p Is
Required for Cell Cycle Progression and
Polarization of the Yeast Cell . . . . . 373
Jianguo Gu and
Masahito Tamura and
Roumen Pankov and
Erik H. J. Danen and
Takahisa Takino and
Kazue Matsumoto and
Kenneth M. Yamada Shc and Fak Differentially Regulate Cell
Motility and Directionality Modulated by
Pten . . . . . . . . . . . . . . . . . . 389
Koichi Ito and
Yasushi Miyashita and
Haruo Kasai Kinetic Control of Multiple Forms of
Ca$^{2+}$ Spikes by Inositol
Trisphosphate in Pancreatic Acinar Cells 405
Xuemei Zeng and
Jason A. Kahana and
Pamela A. Silver and
Mary K. Morphew and
J. Richard McIntosh and
Ian T. Fitch and
John Carbon and
William S. Saunders Slk19p Is a Centromere Protein That
Functions to Stabilize Mitotic Spindles 415
Jeffrey R. Miller and
Brian A. Rowning and
Carolyn A. Larabell and
Julia A. Yang-Snyder and
Rebecca L. Bates and
Randall T. Moon Establishment of the Dorsal--Ventral
Axis in \bionameXenopus Embryos
Coincides with the Dorsal Enrichment of
Dishevelled That Is Dependent on
Cortical Rotation . . . . . . . . . . . 427
Christopher A. Shelton and
J. Clayton Carter and
Gregory C. Ellis and
Bruce Bowerman The Nonmuscle Myosin Regulatory Light
Chain Gene mlc-4 Is Required for
Cytokinesis, Anterior--Posterior
Polarity, and Body Morphology during
\bionameCaenorhabditis elegans
Embryogenesis . . . . . . . . . . . . . 439
Angelika Konzok and
Igor Weber and
Evelyn Simmeth and
Ulrike Hacker and
Markus Maniak and
Annette Müller-Taubenberger Daip1, a \bionameDictyostelium Homologue
of the Yeast Actin--Interacting Protein
1, Is Involved in Endocytosis,
Cytokinesis, and Motility . . . . . . . 453
Georgine Faulkner and
Alberto Pallavicini and
Elide Formentin and
Anna Comelli and
Chiara Ievolella and
Silvia Trevisan and
Gladis Bortoletto and
Paolo Scannapieco and
Michela Salamon and
Vincent Mouly and
Giorgio Valle and
Gerolamo Lanfranchi ZASP: a New Z-band Alternatively Spliced
PDZ-motif Protein . . . . . . . . . . . 465
Fedor Berditchevski and
Elena Odintsova Characterization of
Integrin--Tetraspanin Adhesion Complexes 477
Montserrat Samsó and
Ramon Trujillo and
Georgina B. Gurrola and
Hector H. Valdivia and
Terence Wagenknecht Three-Dimensional Location of the
Imperatoxin a Binding Site on the
Ryanodine Receptor . . . . . . . . . . . 493
Sylvie Dufour and
Alice Beauvais-Jouneau and
Annie Delouvée and
Jean Paul Thiery Differential Function of N--Cadherin and
Cadherin-7 in the Control of Embryonic
Cell Motility . . . . . . . . . . . . . 501
Claire Legrand and
Christine Gilles and
Jean-Marie Zahm and
Myriam Polette and
Anne-Cécile Buisson and
Hervé Kaplan and
Philippe Birembaut and
Jean-Marie Tournier Airway Epithelial Cell Migration
Dynamics: MMP-9 Role in
Cell--Extracellular Matrix Remodeling 517
Hong Ma and
Alan J. Siegel and
Ronald Berezney Association of Chromosome Territories
with the Nuclear Matrix . . . . . . . . 531
Xiangyun Wei and
Suryanarayan Somanathan and
Jagath Samarabandu and
Ronald Berezney Three-Dimensional Visualization of
Transcription Sites and Their
Association with Splicing Factor--Rich
Nuclear Speckles . . . . . . . . . . . . 543
Nayef Jarrous and
Joseph S. Wolenski and
Donna Wesolowski and
Christopher Lee and
Sidney Altman Localization in the Nucleolus and Coiled
Bodies of Protein Subunits of the
Ribonucleoprotein Ribonuclease P . . . . 559
Christina Karlsson and
Stephanie Katich and
Anja Hagting and
Ingrid Hoffmann and
Jonathon Pines Cdc25b and Cdc25c Differ Markedly in
Their Properties as Initiators of
Mitosis . . . . . . . . . . . . . . . . 573
Alexey Khodjakov and
Conly L. Rieder The Sudden Recruitment of $ \gamma
$-Tubulin to the Centrosome at the Onset
of Mitosis and Its Dynamic Exchange
Throughout the Cell Cycle, Do Not
Require Microtubules . . . . . . . . . . 585
John T. Robinson and
Edward J. Wojcik and
Mark A. Sanders and
Maura McGrail and
Thomas S. Hays Cytoplasmic Dynein Is Required for the
Nuclear Attachment and Migration of
Centrosomes during Mitosis in
\bionameDrosophila . . . . . . . . . . . 597
Jonathan S. Bogan and
Harvey F. Lodish Two Compartments for Insulin--Stimulated
Exocytosis in 3t3-L1 Adipocytes Defined
by Endogenous Acrp30 and Glut4 . . . . . 609
Bernhard E. Flucher and
Antonio Conti and
Hiroshi Takeshima and
Vincenzo Sorrentino Type 3 and Type 1 Ryanodine Receptors
Are Localized in Triads of the Same
Mammalian Skeletal Muscle Fibers . . . . 621
Wolfgang A. Linke and
Diane E. Rudy and
Thomas Centner and
Mathias Gautel and
Christian Witt and
Siegfried Labeit and
Carol C. Gregorio I-Band Titin in Cardiac Muscle Is a
Three--Element Molecular Spring and Is
Critical for Maintaining Thin Filament
Structure . . . . . . . . . . . . . . . 631
Pedro J. I. Salas Insoluble $ \gamma
$--Tubulin--Containing Structures Are
Anchored to the Apical Network of
Intermediate Filaments in Polarized
Caco-2 Epithelial Cells . . . . . . . . 645
Michelle Coutu Hresko and
Lawrence A. Schriefer and
Paresh Shrimankar and
Robert H. Waterston Myotactin, a Novel Hypodermal Protein
Involved in Muscle--Cell Adhesion in
\bionameCaenorhabditis elegans . . . . . 659
Jennifer M. Green and
Alexander Zheleznyak and
Jun Chung and
Frederik P. Lindberg and
Marika Sarfati and
William A. Frazier and
Eric J. Brown Role of Cholesterol in Formation and
Function of a Signaling Complex
Involving $ \alpha $ v$ \beta $3,
Integrin--Associated Protein (Cd47), and
Heterotrimeric G Proteins . . . . . . . 673
Laura L. Mitic and
Eveline E. Schneeberger and
Alan S. Fanning and
James Melvin Anderson Connexin-Occludin Chimeras Containing
the Zo--Binding Domain of Occludin
Localize at Mdck Tight Junctions and Nrk
Cell Contacts . . . . . . . . . . . . . 683
Graham Carpenter Employment of the Epidermal Growth
Factor Receptor in Growth
Factor--Independent Signaling Pathways 697
Jason C. Mills and
Nicole L. Stone and
Randall N. Pittman Extranuclear Apoptosis . . . . . . . . . 703
Daniela S. Dimitrova and
Ivan T. Todorov and
Thomas Melendy and
David M. Gilbert Mcm2, but Not Rpa, Is a Component of the
Mammalian Early G1-Phase Prereplication
Complex . . . . . . . . . . . . . . . . 709
Gerald Bacher and
Martin Pool and
Bernhard Dobberstein The Ribosome Regulates the Gtpase of the
$ \beta $-Subunit of the Signal
Recognition Particle Receptor . . . . . 723
Karen Purcell and
Spyros Artavanis-Tsakonas The Developmental Role of warthog, the
Notch Modifier Encoding Drab6 . . . . . 731
Roger Schneiter and
Britta Brügger and
Roger Sandhoff and
Günther Zellnig and
Andrea Leber and
Manfred Lampl and
Karin Athenstaedt and
Claudia Hrastnik and
Sandra Eder and
Günther Daum and
Fritz Paltauf and
Felix T. Wieland and
Sepp D. Kohlwein Electrospray Ionization Tandem Mass
Spectrometry (Esi--Ms/Ms) Analysis of
the Lipid Molecular Species Composition
of Yeast Subcellular Membranes Reveals
Acyl Chain--Based Sorting/Remodeling of
Distinct Molecular Species En Route to
the Plasma Membrane . . . . . . . . . . 741
Ibragim Gaidarov and
James H. Keen Phosphoinositide--Ap-2 Interactions
Required for Targeting to Plasma
Membrane Clathrin-Coated Pits . . . . . 755
Raj J. Advani and
Bin Yang and
Rytis Prekeris and
Kelly C. Lee and
Judith Klumperman and
Richard H. Scheller Vamp-7 Mediates Vesicular Transport from
Endosomes to Lysosomes . . . . . . . . . 765
Cynthia A. Sparks and
Mary Morphew and
Dannel McCollum Sid2p, a Spindle Pole Body Kinase That
Regulates the Onset of Cytokinesis . . . 777
Shuji Kotani and
Hirofumi Tanaka and
Hideyo Yasuda and
Kazuo Todokoro Regulation of APC Activity by
Phosphorylation and Regulatory Factors 791
Steven H. Myster and
Julie A. Knott and
Katrina M. Wysocki and
Eileen O'Toole and
Mary E. Porter Domains in the 1$ \alpha $ Dynein Heavy
Chain Required for Inner Arm Assembly
and Flagellar Motility in Chlamydomonas 801
Evelyne Ferrary and
Michel Cohen-Tannoudji and
Gérard Pehau-Arnaudet and
Alexandre Lapillonne and
Rafika Athman and
Tereza Ruiz and
Lilia Boulouha and
Fatima El Marjou and
Anne Doye and
Jean-Jacques Fontaine and
Claude Antony and
Charles Babinet and
Daniel Louvard and
Frédéric Jaisser and
Sylvie Robine In Vivo, Villin Is Required for
Ca$^{2+}$ -Dependent F--Actin Disruption
in Intestinal Brush Borders . . . . . . 819
Ivan Correia and
Donald Chu and
Ying-Hao Chou and
Robert D. Goldman and
Paul Matsudaira Integrating the Actin and Vimentin
Cytoskeletons . . . . . . . . . . . . . 831
Snezhana Oliferenko and
Karin Paiha and
Thomas Harder and
Volker Gerke and
Christoph Schwärzler and
Heinz Schwarz and
Hartmut Beug and
Ursula Günthert and
Lukas A. Huber Analysis of Cd44-Containing Lipid Rafts 843
Keith Orford and
Caroline C. Orford and
Stephen W. Byers Exogenous Expression of $ \beta
$-Catenin Regulates Contact Inhibition,
Anchorage--Independent Growth, Anoikis,
and Radiation--Induced Cell Cycle Arrest 855
Helen Gillham and
Matthew C. H. M. Golding and
Rainer Pepperkok and
William J. Gullick Intracellular Movement of Green
Fluorescent Protein--Tagged
Phosphatidylinositol 3-Kinase in
Response to Growth Factor Receptor
Signaling . . . . . . . . . . . . . . . 869
David C. Martin and
John L. Fowlkes and
Bojana Babic and
Rama Khokha Insulin-like Growth Factor II Signaling
in Neoplastic Proliferation Is Blocked
by Transgenic Expression of the
Metalloproteinase Inhibitor Timp-1 . . . 881
Isao Tachibana and
Martin E. Hemler Role of Transmembrane 4 Superfamily
(Tm4sf) Proteins Cd9 and Cd81 in Muscle
Cell Fusion and Myotube Maintenance . . 893
Emmy P. Rogakou and
Chye Boon and
Christophe Redon and
William M. Bonner Megabase Chromatin Domains Involved in
DNA Double--Strand Breaks in Vivo . . . 905
Valerie A. Kickhoefer and
Amara C. Siva and
Nancy L. Kedersha and
Elisabeth M. Inman and
Cristina Ruland and
Michel Streuli and
Leonard H. Rome The 193-Kd Vault Protein, Vparp, Is a
Novel Poly(Adp--Ribose) Polymerase . . . 917
Jean Schneikert and
Susanne Hübner and
Elke Martin and
Andrew C. B. Cato A Nuclear Action of the Eukaryotic
Cochaperone Rap46 in Downregulation of
Glucocorticoid Receptor Activity . . . . 929
G. K. T. Chan and
S. A. Jablonski and
V. Sudakin and
J. C. Hittle and
T. J. Yen Human Bubr1 Is a Mitotic Checkpoint
Kinase That Monitors Cenp-E Functions at
Kinetochores and Binds the Cyclosome/APC 941
A. R. Vaillant and
I. Mazzoni and
C. Tudan and
M. Boudreau and
D. R. Kaplan and
F. D. Miller Depolarization and Neurotrophins
Converge on the Phosphatidylinositol
3--Kinase--Akt Pathway to
Synergistically Regulate Neuronal
Survival . . . . . . . . . . . . . . . . 955
Jesús Espada and
Mirna Pérez-Moreno and
Vania M. M. Braga and
Pablo Rodriguez-Viciana and
Amparo Cano H-Ras Activation Promotes Cytoplasmic
Accumulation and Phosphoinositide 3-Oh
Kinase Association of $ \beta $-Catenin
in Epidermal Keratinocytes . . . . . . . 967
Charles B. Shuster and
David R. Burgess Parameters That Specify the Timing of
Cytokinesis . . . . . . . . . . . . . . 981
Lesley J. Page and
Penelope J. Sowerby and
Winnie W. Y. Lui and
Margaret S. Robinson $ \gamma $-Synergin . . . . . . . . . . 993
C. Fiona Cullen and
Peter Deák and
David M. Glover and
Hiroyuki Ohkura mini spindles . . . . . . . . . . . . . 1005
Chandra L. Theesfeld and
Javier E. Irazoqui and
Kerry Bloom and
Daniel J. Lew The Role of Actin in Spindle Orientation
Changes during the \bionameSaccharomyces
cerevisiae Cell Cycle . . . . . . . . . 1019
Irina Kaverina and
Olga Krylyshkina and
J. Victor Small Microtubule Targeting of Substrate
Contacts Promotes Their Relaxation and
Dissociation . . . . . . . . . . . . . . 1033
P. C. Bridgman Myosin VA Movements in Normal and
Dilute--Lethal Axons Provide Support for
a Dual Filament Motor Complex . . . . . 1045
Min-gang Li and
Madeline Serr and
Kevin Edwards and
Susan Ludmann and
Daisuke Yamamoto and
Lewis G. Tilney and
Christine M. Field and
Thomas S. Hays Filamin Is Required for Ring Canal
Assembly and Actin Organization during
\bionameDrosophila Oogenesis . . . . . . 1061
Daniela C. Zarnescu and
Graham H. Thomas Apical Spectrin Is Essential for
Epithelial Morphogenesis but Not
Apicobasal Polarity in
\bionameDrosophila . . . . . . . . . . . 1075
Joseph E. Italiano and
Murray Stewart and
Thomas M. Roberts Localized Depolymerization of the Major
Sperm Protein Cytoskeleton Correlates
with the Forward Movement of the Cell
Body in the Amoeboid Movement of
Nematode Sperm . . . . . . . . . . . . . 1087
Aneil Mallavarapu and
Tim Mitchison Regulated Actin Cytoskeleton Assembly at
Filopodium Tips Controls Their Extension
and Retraction . . . . . . . . . . . . . 1097
David A. Cheresh and
Jie Leng and
Richard L. Klemke Regulation of Cell Contraction and
Membrane Ruffling by Distinct Signals in
Migratory Cells . . . . . . . . . . . . 1107
Wataru Ikeda and
Hiroyuki Nakanishi and
Jun Miyoshi and
Kenji Mandai and
Hiroyoshi Ishizaki and
Miki Tanaka and
Atushi Togawa and
Kenichi Takahashi and
Hideo Nishioka and
Hisahiro Yoshida and
Akira Mizoguchi and
Shin-ichi Nishikawa and
Yoshimi Takai Afadin . . . . . . . . . . . . . . . . . 1117
Heather Zhou and
David J. Glass and
George D. Yancopoulos and
Joshua R. Sanes Distinct Domains of Musk Mediate Its
Abilities to Induce and to Associate
with Postsynaptic Specializations . . . 1133
Isaac Rabinovitz and
Alex Toker and
Arthur M. Mercurio Protein Kinase C--Dependent Mobilization
of the $ \alpha $6$ \beta $4 Integrin
from Hemidesmosomes and Its Association
with Actin--Rich Cell Protrusions Drive
the Chemotactic Migration of Carcinoma
Cells . . . . . . . . . . . . . . . . . 1147
Li Sun and
Olugbenga A. Adebanjo and
Baljit S. Moonga and
Susanne Corisdeo and
Hindupur K. Anandatheerthavarada and
Gopa Biswas and
Toshiya Arakawa and
Yoshiyuki Hakeda and
Antoliy Koval and
Bali Sodam and
Peter J. R. Bevis and
A. James Moser and
F. Anthony Lai and
Solomon Epstein and
Bruce R. Troen and
Masayoshi Kumegawa and
Mone Zaidi Cd38\slash Adp-Ribosyl Cyclase . . . . . 1161
C. A. Haney and
Z. Sahenk and
C. Li and
V. P. Lemmon and
J. Roder and
B. D. Trapp Heterophilic Binding of L1 on
Unmyelinated Sensory Axons Mediates
Schwann Cell Adhesion and Is Required
for Axonal Survival . . . . . . . . . . 1173
Rudolph D. Paladini and
Pierre A. Coulombe The Functional Diversity of Epidermal
Keratins Revealed by the Partial Rescue
of the Keratin 14 Null Phenotype by
Keratin 16 . . . . . . . . . . . . . . . 1185
Jason A. Kahana and
Don W. Cleveland Beyond Nuclear Transport . . . . . . . . 1205
Nicolas Sadoni and
Sabine Langer and
Christine Fauth and
Giorgio Bernardi and
Thomas Cremer and
Bryan M. Turner and
Daniele Zink Nuclear Organization of Mammalian
Genomes . . . . . . . . . . . . . . . . 1211
Thomas Beck and
Anja Schmidt and
Michael N. Hall Starvation Induces Vacuolar Targeting
and Degradation of the Tryptophan
Permease in Yeast . . . . . . . . . . . 1227
Rafael García-Mata and
Zsuzsa Bebök and
Eric J. Sorscher and
Elizabeth S. Sztul Characterization and Dynamics of
Aggresome Formation by a Cytosolic
Gfp--Chimera . . . . . . . . . . . . . . 1239
Maria Elena Bottazzi and
Xiaoyun Zhu and
Ralph M. Böhmer and
Richard K. Assoian Regulation of P21$^{\rm cip1}$
Expression by Growth Factors and the
Extracellular Matrix Reveals a Role for
Transient ERK Activity in G1 Phase . . . 1255
Stephen L. Rogers and
Ryan L. Karcher and
Joseph T. Roland and
Alexander A. Minin and
Walter Steffen and
Vladimir I. Gelfand Regulation of Melanosome Movement in the
Cell Cycle by Reversible Association
with Myosin V . . . . . . . . . . . . . 1265
Amena Rahman and
Adeela Kamal and
Elizabeth A. Roberts and
Lawrence S. B. Goldstein Defective Kinesin Heavy Chain Behavior
in Mouse Kinesin Light Chain Mutants . . 1277
Niklas Larsson and
Bo Segerman and
Bonnie Howell and
Kajsa Fridell and
Lynne Cassimeris and
Martin Gullberg Op18\slash Stathmin Mediates Multiple
Region--Specific Tubulin and
Microtubule--Regulating Activities . . . 1289
Brooke M. McCartney and
Herman A. Dierick and
Catherine Kirkpatrick and
Melissa M. Moline and
Annette Baas and
Mark Peifer and
Amy Bejsovec Drosophila Apc2 Is a
Cytoskeletally--Associated Protein That
Regulates Wingless Signaling in the
Embryonic Epidermis . . . . . . . . . . 1303
Coumaran Egile and
Thomas P. Loisel and
Valérie Laurent and
Rong Li and
Dominique Pantaloni and
Philippe J. Sansonetti and
Marie-France Carlier Activation of the Cdc42 Effector N-Wasp
by the \bionameShigella flexneri Icsa
Protein Promotes Actin Nucleation by
Arp2/3 Complex and Bacterial Actin-Based
Motility . . . . . . . . . . . . . . . . 1319
Jennifer R. Robbins and
Angela I. Barth and
Hél\`ene Marquis and
Eugenio L. de Hostos and
W. James Nelson and
Julie A. Theriot \bionameListeria monocytogenes Exploits
Normal Host Cell Processes to Spread
from Cell to Cell . . . . . . . . . . . 1333
Yihong Ye and
Mark E. Fortini Apoptotic Activities of Wild-Type and
Alzheimer's Disease-Related Mutant
Presenilins in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 1351
H. Ueda and
J. M. Levine and
R. H. Miller and
B. D. Trapp Rat Optic Nerve Oligodendrocytes Develop
in the Absence of Viable Retinal
Ganglion Cell Axons . . . . . . . . . . 1365
Tsuyoshi Sugiura and
Fedor Berditchevski Function of $ \alpha $3$ \beta
$1--Tetraspanin Protein Complexes in
Tumor Cell Invasion. Evidence for the
Role of the Complexes in Production of
Matrix Metalloproteinase 2 (Mmp-2) . . . 1375
Jane C. Stinchcombe and
Gillian M. Griffiths Regulated Secretion from Hemopoietic
Cells . . . . . . . . . . . . . . . . . 1
Y. Altschuler and
S.-H. Liu and
L. Katz and
K. Tang and
S. Hardy and
F. Brodsky and
G. Apodaca and
K. Mostov Adp-Ribosylation Factor 6 and
Endocytosis at the Apical Surface of
Madin--Darby Canine Kidney Cells . . . . 7
Pernette J. Verschure and
Ineke van der Kraan and
Erik M. M. Manders and
Roel van Driel Spatial Relationship between
Transcription Sites and Chromosome
Territories . . . . . . . . . . . . . . 13
M. Cristina Cardoso and
Heinrich Leonhardt DNA Methyltransferase Is Actively
Retained in the Cytoplasm during Early
Development . . . . . . . . . . . . . . 25
Stefan Richter and
Gayle K. Lamppa Stromal Processing Peptidase Binds
Transit Peptides and Initiates Their
ATP-Dependent Turnover in Chloroplasts 33
Caroline E. Shamu and
Craig M. Story and
Tom A. Rapoport and
Hidde L. Ploegh The Pathway of Us11-Dependent
Degradation of Mhc Class I Heavy Chains
Involves a Ubiquitin--Conjugated
Intermediate . . . . . . . . . . . . . . 45
H. L. Zhang and
R. H. Singer and
G. J. Bassell Neurotrophin Regulation of $ \beta
$-Actin mRNA and Protein Localization
within Growth Cones . . . . . . . . . . 59
Hongran Fan and
Paul A. Khavari Sonic Hedgehog Opposes Epithelial Cell
Cycle Arrest . . . . . . . . . . . . . . 71
Frank E. Jones and
Thomas Welte and
Xin-Yuan Fu and
David F. Stern Erbb4 Signaling in the Mammary Gland Is
Required for Lobuloalveolar Development
and Stat5 Activation during Lactation 77
Julio A. Aguirre Ghiso and
Katherine Kovalski and
Liliana Ossowski Tumor Dormancy Induced by Downregulation
of Urokinase Receptor in Human Carcinoma
Involves Integrin and MAPK Signaling . . 89
Hidemitsu Harada and
Päivi Kettunen and
Han-Sung Jung and
Tuija Mustonen and
Y. Alan Wang and
Irma Thesleff Localization of Putative Stem Cells in
Dental Epithelium and Their Association
with Notch and Fgf Signaling . . . . . . 105
I. Imafuku and
T. Masaki and
M. Waragai and
S. Takeuchi and
M. Kawabata and
S.-i. Hirai and
S. Ohno and
L. E. Nee and
C. F. Lippa and
I. Kanazawa and
M. Imagawa and
H. Okazawa Presenilin 1 Suppresses the Function of
C-Jun Homodimers via Interaction with
Qm/Jif-1 . . . . . . . . . . . . . . . . 121
Pierre Gönczy and
Silke Pichler and
Matthew Kirkham and
Anthony A. Hyman Cytoplasmic Dynein Is Required for
Distinct Aspects of Mtoc Positioning,
Including Centrosome Separation, in the
One Cell Stage \bionameCaenorhabditis
elegans Embryo . . . . . . . . . . . . . 135
Xiaolu Wang and
Mark Kibschull and
Michael M. Laue and
Beate Lichte and
Elisabeth Petrasch-Parwez and
Manfred W. Kilimann Aczonin, a 550-Kd Putative Scaffolding
Protein of Presynaptic Active Zones,
Shares Homology Regions with Rim and
Bassoon and Binds Profilin . . . . . . . 151
Pierre-Alain Delley and
Michael N. Hall Cell Wall Stress Depolarizes Cell Growth
via Hyperactivation of Rho1 . . . . . . 163
Laurence Abrami and
F. Gisou van der Goot Plasma Membrane Microdomains Act as
Concentration Platforms to Facilitate
Intoxication by Aerolysin . . . . . . . 175
Kazumasa Morita and
Hiroyuki Sasaki and
Mikio Furuse and
Shoichiro Tsukita Endothelial Claudin . . . . . . . . . . 185
Noriyuki Sonoda and
Mikio Furuse and
Hiroyuki Sasaki and
Shigenobu Yonemura and
Jun Katahira and
Yasuhiko Horiguchi and
Shoichiro Tsukita Clostridium perfringens Enterotoxin
Fragment Removes Specific Claudins from
Tight Junction Strands . . . . . . . . . 195
Madalena Tarsounas and
Takashi Morita and
Ronald E. Pearlman and
Peter B. Moens Rad51 and Dmc1 Form Mixed Complexes
Associated with Mouse Meiotic Chromosome
Cores and Synaptonemal Complexes . . . . 207
Alexander M. Ishov and
Alexey G. Sotnikov and
Dmitri Negorev and
Olga V. Vladimirova and
Norma Neff and
Tetsu Kamitani and
Edward T. H. Yeh and
Jerome F. Strauss and
Gerd G. Maul Pml Is Critical for Nd10 Formation and
Recruits the Pml--Interacting Protein
Daxx to This Nuclear Structure When
Modified by Sumo-1 . . . . . . . . . . . 221
Anton A. Titov and
Günter Blobel The Karyopherin Kap122p/Pdr6p Imports
Both Subunits of the Transcription
Factor IIA into the Nucleus . . . . . . 235
Sunjong Kwon and
Elisa Barbarese and
John H. Carson The Cis--Acting RNA Trafficking Signal
from Myelin Basic Protein mRNA and Its
Cognate Trans--Acting Ligand Hnrnp A2
Enhance CaP--Dependent Translation . . . 247
Veit Goder and
Christoph Bieri and
Martin Spiess Glycosylation Can Influence Topogenesis
of Membrane Proteins and Reveals Dynamic
Reorientation of Nascent Polypeptides
within the Translocon . . . . . . . . . 257
Macie B. Walker and
Laura M. Roy and
Eric Coleman and
Rodger Voelker and
Alice Barkan The Maize tha4 Gene Functions in
Sec--Independent Protein Transport in
Chloroplasts and Is Related to hcf106,
tatA, and tatB . . . . . . . . . . . . . 267
Wim G. Annaert and
Lyne Levesque and
Kathleen Craessaerts and
Inge Dierinck and
Greet Snellings and
David Westaway and
Peter St. George-Hyslop and
Barbara Cordell and
Paul Fraser and
Bart De Strooper Presenilin 1 Controls $ \gamma
$-Secretase Processing of Amyloid
Precursor Protein in Pre-Golgi
Compartments of Hippocampal Neurons . . 277
Nobuaki Furuno and
Nicole den Elzen and
Jonathon Pines Human Cyclin a Is Required for Mitosis
until Mid Prophase . . . . . . . . . . . 295
D. Mark Eckley and
Steven R. Gill and
Karin A. Melkonian and
James B. Bingham and
Holly V. Goodson and
John E. Heuser and
Trina A. Schroer Analysis of Dynactin Subcomplexes
Reveals a Novel Actin--Related Protein
Associated with the Arp1 Minifilament
Pointed End . . . . . . . . . . . . . . 307
N. J. Quintyne and
S. R. Gill and
D. M. Eckley and
C. L. Crego and
D. A. Compton and
T. A. Schroer Dynactin Is Required for Microtubule
Anchoring at Centrosomes . . . . . . . . 321
Frank R. Cottingham and
Larisa Gheber and
Dana L. Miller and
M. Andrew Hoyt Novel Roles for \bionameSaccharomyces
cerevisiae Mitotic Spindle Motors . . . 335
Vicki Mountain and
Calvin Simerly and
Louisa Howard and
Asako Ando and
Gerald Schatten and
Duane A. Compton The Kinesin--Related Protein, Hset,
Opposes the Activity of Eg5 and
Cross--Links Microtubules in the
Mammalian Mitotic Spindle . . . . . . . 351
Richard W. Nelson and
Barry M. Gumbiner A Cell--Free Assay System for $ \beta
$-Catenin Signaling That Recapitulates
Direct Inductive Events in the Early
\bionameXenopus laevis Embryo . . . . . 367
Matthias M. Ledig and
Fawaz Haj and
John L. Bixby and
Andrew W. Stoker and
Bernhard K. Mueller The Receptor Tyrosine Phosphatase Cryp$
\alpha $ Promotes Intraretinal Axon
Growth . . . . . . . . . . . . . . . . . 375
Xue-Qing Wang and
Frederik P. Lindberg and
William A. Frazier Integrin-Associated Protein Stimulates $
\alpha $2$ \beta $1-Dependent Chemotaxis
via GI--Mediated Inhibition of Adenylate
Cyclase and Extracellular--Regulated
Kinases . . . . . . . . . . . . . . . . 389
Johanna Ivaska and
Hilkka Reunanen and
Jukka Westermarck and
Leeni Koivisto and
Veli-Matti Kähäri and
Jyrki Heino Integrin $ \alpha $2$ \beta $1 Mediates
Isoform--Specific Activation of p38 and
Upregulation of Collagen Gene
Transcription by a Mechanism Involving
the $ \alpha $2 Cytoplasmic Tail . . . . 401
Dirk Geerts and
Lionel Fontao and
Mirjam G. Nievers and
Roel Q. J. Schaapveld and
Patricia E. Purkis and
Grant N. Wheeler and
E. Birgitte Lane and
Irene M. Leigh and
Arnoud Sonnenberg Binding of Integrin $ \alpha $6$ \beta
$4 to Plectin Prevents Plectin
Association with F--Actin but Does Not
Interfere with Intermediate Filament
Binding . . . . . . . . . . . . . . . . 417
Takayoshi Kirisako and
Misuzu Baba and
Naotada Ishihara and
Kouichi Miyazawa and
Mariko Ohsumi and
Tamotsu Yoshimori and
Takeshi Noda and
Yoshinori Ohsumi Formation Process of Autophagosome Is
Traced with Apg8/Aut7p in Yeast . . . . 435
Peter W. Janes and
Steven C. Ley and
Anthony I. Magee Aggregation of Lipid Rafts Accompanies
Signaling via the T Cell Antigen
Receptor . . . . . . . . . . . . . . . . 447
Douglas G. Cole Kinesin-Ii, Coming and Going . . . . . . 463
Minoru Fukuda and
Nobuyoshi Hiraoka and
Jiunn-Chern Yeh C-Type Lectins and Sialyl Lewis X
Oligosaccharides . . . . . . . . . . . . 467
Landon L. Moore and
Mike Morrison and
Mark B. Roth Hcp-1, a Protein Involved in Chromosome
Segregation, Is Localized to the
Centromere of Mitotic Chromosomes in
\bionameCaenorhabditis elegans . . . . . 471
Aruna Purohit and
Sharon H. Tynan and
Richard Vallee and
Stephen J. Doxsey Direct Interaction of Pericentrin with
Cytoplasmic Dynein Light Intermediate
Chain Contributes to Mitotic Spindle
Organization . . . . . . . . . . . . . . 481
Nira Pollock and
Eugenio L. de Hostos and
Christoph W. Turck and
Ronald D. Vale Reconstitution of Membrane Transport
Powered by a Novel Dimeric Kinesin Motor
of the Unc104/Kif1a Family Purified from
\bionameDictyostelium . . . . . . . . . 493
Krishanu Ray and
Sharon E. Perez and
Zhaohuai Yang and
Jenny Xu and
Bruce W. Ritchings and
Hermann Steller and
Lawrence S. B. Goldstein Kinesin-II Is Required for Axonal
Transport of Choline Acetyltransferase
in \bionameDrosophila . . . . . . . . . 507
Dawn Signor and
Karen P. Wedaman and
Jose T. Orozco and
Noelle D. Dwyer and
Cornelia I. Bargmann and
Lesilee S. Rose and
Jonathan M. Scholey Role of a Class Dhc1b Dynein in
Retrograde Transport of Ift Motors and
Ift Raft Particles along Cilia, but Not
Dendrites, in Chemosensory Neurons of
Living \bionameCaenorhabditis elegans 519
Jean-Martin Beaulieu and
Minh Dang Nguyen and
Jean-Pierre Julien Late Onset Death of Motor Neurons in
Mice Overexpressing Wild--Type
Peripherin . . . . . . . . . . . . . . . 531
Ana Olivera and
Takafumi Kohama and
Lisa Edsall and
Victor Nava and
Olivier Cuvillier and
Samantha Poulton and
Sarah Spiegel Sphingosine Kinase Expression Increases
Intracellular Sphingosine-1-Phosphate
and Promotes Cell Growth and Survival 545
Chang Y. Chung and
Richard A. Firtel Paka, a Putative Pak Family Member, Is
Required for Cytokinesis and the
Regulation of the Cytoskeleton in
\bionameDictyostelium discoideum Cells
during Chemotaxis . . . . . . . . . . . 559
Ellen F. Foxman and
Eric J. Kunkel and
Eugene C. Butcher Integrating Conflicting Chemotactic
Signals . . . . . . . . . . . . . . . . 577
R. Bryan Sutton and
James A. Ernst and
Axel T. Brunger Crystal Structure of the Cytosolic
C2a--C2b Domains of Synaptotagmin III 589
Clotilde Théry and
Armelle Regnault and
Jérôme Garin and
Joseph Wolfers and
Laurence Zitvogel and
Paola Ricciardi-Castagnoli and
Graça Raposo and
Sebastian Amigorena Molecular Characterization of Dendritic
Cell--Derived Exosomes . . . . . . . . . 599
Mark W. Renshaw and
Leo S. Price and
Martin Alexander Schwartz Focal Adhesion Kinase Mediates the
Integrin Signaling Requirement for
Growth Factor Activation of Map Kinase 611
Neil O. Carragher and
Bodo Levkau and
Russell Ross and
Elaine W. Raines Degraded Collagen Fragments Promote
Rapid Disassembly of Smooth Muscle Focal
Adhesions That Correlates with Cleavage
of Pp125$^{\rm FAK}$, Paxillin, and
Talin . . . . . . . . . . . . . . . . . 619
Marvin T. Nieman and
Ryan S. Prudoff and
Keith R. Johnson and
Margaret J. Wheelock N-Cadherin Promotes Motility in Human
Breast Cancer Cells Regardless of Their
E--Cadherin Expression . . . . . . . . . 631
Derek J. Blake and
Richard Hawkes and
Matthew A. Benson and
Phillip W. Beesley Different Dystrophin-like Complexes Are
Expressed in Neurons and Glia . . . . . 645
K. Haug-Collet and
B. Pearson and
R. Webel and
R. T. Szerencsei and
R. J. Winkfein and
P. P. M. Schnetkamp and
N. J. Colley Cloning and Characterization of a
Potassium-Dependent Sodium/Calcium
Exchanger in \bionameDrosophila . . . . 659
Minna M. Poranen and
Rimantas Daugelavi\vcius and
Päivi M. Ojala and
Michael W. Hess and
Dennis H. Bamford A Novel Virus--Host Cell Membrane
Interaction . . . . . . . . . . . . . . 671
Ariel Blocker and
Pierre Gounon and
Eric Larquet and
Kirsten Niebuhr and
Véronique Cabiaux and
Claude Parsot and
Philippe Sansonetti The Tripartite Type III Secreton of
Shigella flexneri Inserts Ipab and Ipac
into Host Membranes . . . . . . . . . . 683
Charles P. Ordahl Myogenic Shape--Shifters . . . . . . . . 695
Hiromi Sesaki and
Robert E. Jensen Division versus Fusion: Dnm1p and Fzo1p
Antagonistically Regulate Mitochondrial
Shape . . . . . . . . . . . . . . . . . 699
Li Zeng and
Luca D'Alessandri and
Markus B. Kalousek and
Lloyd Vaughan and
Catherine J. Pallen Protein Tyrosine Phosphatase $ \alpha $
(Ptp$ \alpha $) and Contactin Form a
Novel Neuronal Receptor Complex Linked
to the Intracellular Tyrosine Kinase Fyn 707
Teresa Carvalho and
Fátima Almeida and
Alexandre Calapez and
Miguel Lafarga and
Maria T. Berciano and
Maria Carmo-Fonseca The Spinal Muscular Atrophy Disease Gene
Product, Smn . . . . . . . . . . . . . . 715
Susan M. VanRheenen and
Xiaochun Cao and
Stephanie K. Sapperstein and
Elbert C. Chiang and
Vladimir V. Lupashin and
Charles Barlowe and
M. Gerard Waters Sec34p, a Protein Required for Vesicle
Tethering to the Yeast Golgi Apparatus,
Is in a Complex with Sec35p . . . . . . 729
Jamie White and
Ludger Johannes and
Frédéric Mallard and
Andreas Girod and
Stephan Grill and
Sigrid Reinsch and
Patrick Keller and
Barbara Tzschaschel and
Arnaud Echard and
Bruno Goud and
Ernst H. K. Stelzer Rab6 Coordinates a Novel Golgi to ER
Retrograde Transport Pathway in Live
Cells . . . . . . . . . . . . . . . . . 743
Chia-Che Chang and
Daniel S. Warren and
Katherine A. Sacksteder and
Stephen J. Gould Pex12 Interacts with Pex5 and Pex10 and
Acts Downstream of Receptor Docking in
Peroxisomal Matrix Protein Import . . . 761
Christoph Driessen and
Rebecca A. R. Bryant and
Ana-Maria Lennon-Duménil and
José A. Villadangos and
Paula Wolf Bryant and
Guo-Ping Shi and
Harold A. Chapman and
Hidde L. Ploegh Cathepsin S Controls the Trafficking and
Maturation of Mhc Class II Molecules in
Dendritic Cells . . . . . . . . . . . . 775
Daniel Schott and
Jackson Ho and
David Pruyne and
Anthony Bretscher The Cooh--Terminal Domain of Myo2p, a
Yeast Myosin V, Has a Direct Role in
Secretory Vesicle Targeting . . . . . . 791
Ruth M. Kluck and
Mauro Degli Esposti and
Guy Perkins and
Christian Renken and
Tomomi Kuwana and
Ella Bossy-Wetzel and
Martin Goldberg and
Terry Allen and
Michael J. Barber and
Douglas R. Green and
Donald D. Newmeyer The Pro--Apoptotic Proteins, Bid and
Bax, Cause a Limited Permeabilization of
the Mitochondrial Outer Membrane That Is
Enhanced by Cytosol . . . . . . . . . . 809
Li Fang and
Sam W. Lee and
Stuart A. Aaronson Comparative Analysis of P73 and P53
Regulation and Effector Functions . . . 823
William B. Kiosses and
R. Hugh Daniels and
Carol Otey and
Gary M. Bokoch and
Martin Alexander Schwartz A Role for P21-Activated Kinase in
Endothelial Cell Migration . . . . . . . 831
Stephen P. Holly and
Kendall J. Blumer Pak-Family Kinases Regulate Cell and
Actin Polarization Throughout the Cell
Cycle of \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 845
Fabienne Fava and
Brigitte Raynaud-Messina and
Jeanne Leung-Tack and
Laurent Mazzolini and
Min Li and
Jean Claude Guillemot and
Didier Cachot and
Yvette Tollon and
Pascual Ferrara and
Michel Wright Human 76p . . . . . . . . . . . . . . . 857
Luciana De Angelis and
Libera Berghella and
Marcello Coletta and
Laura Lattanzi and
Malvina Zanchi and
M. Gabriella and
Carola Ponzetto and
Giulio Cossu Skeletal Myogenic Progenitors
Originating from Embryonic Dorsal Aorta
Coexpress Endothelial and Myogenic
Markers and Contribute to Postnatal
Muscle Growth and Regeneration . . . . . 869
Peter J. Mohler and
Silvia M. Kreda and
Richard C. Boucher and
Marius Sudol and
M. Jackson Stutts and
Sharon L. Milgram Yes-Associated Protein 65 Localizes
P62$^{c - - Yes}$ to the Apical
Compartment of Airway Epithelia by
Association with Ebp50 . . . . . . . . . 879
Mikio Furuse and
Hiroyuki Sasaki and
Shoichiro Tsukita Manner of Interaction of Heterogeneous
Claudin Species within and between Tight
Junction Strands . . . . . . . . . . . . 891
Sanford M. Simon An Award for Cell Biology . . . . . . . 1
Adriana Verschoor and
Trevor Lithgow A First Glimpse at the Structure of the
Tom Translocase from the Mitochondrial
Outer Membrane . . . . . . . . . . . . . 905
Bjorn R. Olsen Life without Perlecan Has Its Problems 909
Teresa Sullivan and
Diana Escalante-Alcalde and
Harshida Bhatt and
Miriam Anver and
Narayan Bhat and
Kunio Nagashima and
Colin L. Stewart and
Brian Burke Loss of a--Type Lamin Expression
Compromises Nuclear Envelope Integrity
Leading to Muscular Dystrophy . . . . . 913
Takashi Tatsumoto and
Xiaozhen Xie and
Rayah Blumenthal and
Isamu Okamoto and
Toru Miki Human Ect2 Is an Exchange Factor for Rho
GTPases, Phosphorylated in G2/M Phases,
and Involved in Cytokinesis . . . . . . 921
Charles C. Fink and
Boris Slepchenko and
Ion I. Moraru and
James Schaff and
James Watras and
Leslie M. Loew Morphological Control of
Inositol--1,4,5--Trisphosphate--Dependent Signals 929
Stefan Kappe and
Thomas Bruderer and
Soren Gantt and
Hisashi Fujioka and
Victor Nussenzweig and
Robert Ménard Conservation of a Gliding Motility and
Cell Invasion Machinery in Apicomplexan
Parasites . . . . . . . . . . . . . . . 937
Paloma Más and
Roger N. Beachy Replication of Tobacco Mosaic Virus on
Endoplasmic Reticulum and Role of the
Cytoskeleton and Virus Movement Protein
in Intracellular Distribution of Viral
RNA . . . . . . . . . . . . . . . . . . 945
Uwe Ahting and
Clemens Thun and
Reiner Hegerl and
Dieter Typke and
Frank E. Nargang and
Walter Neupert and
Stephan Nussberger The Tom Core Complex . . . . . . . . . . 959
Akiharu Kubo and
Hiroyuki Sasaki and
Akiko Yuba-Kubo and
Shoichiro Tsukita and
Nobuyuki Shiina Centriolar Satellites . . . . . . . . . 969
Erica S. Johnson and
Günter Blobel Cell Cycle--Regulated Attachment of the
Ubiquitin--Related Protein Sumo to the
Yeast Septins . . . . . . . . . . . . . 981
Shmuel Tuvia and
Mona Buhusi and
Lydia Davis and
Mary Reedy and
Vann Bennett Ankyrin-B Is Required for Intracellular
Sorting of Structurally Diverse
Ca$^{2+}$ Homeostasis Proteins . . . . . 995
Eva E. Sander and
Jean P. ten Klooster and
Sanne van Delft and
Rob A. van der Kammen and
John G. Collard Rac Downregulates Rho Activity . . . . . 1009
Yoji Kawano and
Yuko Fukata and
Noriko Oshiro and
Mutsuki Amano and
Toshikazu Nakamura and
Masaaki Ito and
Fumio Matsumura and
Masaki Inagaki and
Kozo Kaibuchi Phosphorylation of Myosin--Binding
Subunit (Mbs) of Myosin Phosphatase by
Rho--Kinase in Vivo . . . . . . . . . . 1023
Wenchuan Liang and
Hans M. Warrick and
James A. Spudich A Structural Model for Phosphorylation
Control of \bionameDictyostelium Myosin
II Thick Filament Assembly . . . . . . . 1039
Cédric Raoul and
Christopher E. Henderson and
Brigitte Pettmann Programmed Cell Death of Embryonic
Motoneurons Triggered through the FAS
Death Receptor . . . . . . . . . . . . . 1049
Robin E. Bachelder and
Mark J. Ribick and
Alessandra Marchetti and
Rita Falcioni and
Silvia Soddu and
Kathryn R. Davis and
Arthur M. Mercurio P53 Inhibits $ \alpha 6 \beta 4 $
Integrin Survival Signaling by Promoting
the Caspase 3-Dependent Cleavage of
Akt/PKB . . . . . . . . . . . . . . . . 1063
Shaoqing Tang and
Yunling Gao and
J. Anthony Ware Enhancement of Endothelial Cell
Migration and in Vitro Tube Formation by
Tap20, a Novel $ \beta $5
Integrin--Modulating, Pkc$ \theta
$-Dependent Protein . . . . . . . . . . 1073
Minyi Gu and
Xiaodong Xi and
Graham D. Englund and
Michael C. Berndt and
Xiaoping Du Analysis of the Roles of 14-3-3 in the
Platelet Glycoprotein Ib--IX--Mediated
Activation of Integrin $ \alpha_{IIb} $
$ \beta_3 $ Using a Reconstituted
Mammalian Cell Expression Model . . . . 1085
Kimitoshi Yagami and
Jo-Young Suh and
Motomi Enomoto-Iwamoto and
Eiki Koyama and
William R. Abrams and
Irving M. Shapiro and
Maurizio Pacifici and
Masahiro Iwamoto Matrix Gla Protein Is a Developmental
Regulator of Chondrocyte Mineralization
And, When Constitutively Expressed,
Blocks Endochondral and Intramembranous
Ossification in the Limb . . . . . . . . 1097
Mercedes Costell and
Erika Gustafsson and
Attila Aszódi and
Matthias Mörgelin and
Wilhelm Bloch and
Ernst Hunziker and
Klaus Addicks and
Rupert Timpl and
Reinhard Fässler Perlecan Maintains the Integrity of
Cartilage and Some Basement Membranes 1109
Ben A. Barres and
Martin C. Raff Axonal Control of Oligodendrocyte
Development . . . . . . . . . . . . . . 1123
Carmen Blanco-Aparicio and
Josema Torres and
Rafael Pulido A Novel Regulatory Mechanism of Map
Kinases Activation and Nuclear
Translocation Mediated by Pka and the
Ptp--Sl Tyrosine Phosphatase . . . . . . 1129
Heinrich J. G. Matthies and
Lisa G. Messina and
Ruria Namba and
Kimberly J. Greer and
M. Y. Walker and
R. Scott Hawley Mutations in the $ \alpha $-Tubulin 67C
Gene Specifically Impair Achiasmate
Segregation in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 1137
Jeffrey L. Dupree and
Jean-Antoine Girault and
Brian Popko Axo-Glial Interactions Regulate the
Localization of Axonal Paranodal
Proteins . . . . . . . . . . . . . . . . 1145
Angela Taddei and
Dani\`ele Roche and
Jean-Baptiste Sibarita and
Bryan M. Turner and
Genevi\`eve Almouzni Duplication and Maintenance of
Heterochromatin Domains . . . . . . . . 1153
Philippe Collas and
Katherine Le Guellec and
Kjetil Taskén The a--Kinase--Anchoring Protein Akap95
Is a Multivalent Protein with a Key Role
in Chromatin Condensation at Mitosis . . 1167
Bernard Charroux and
Livio Pellizzoni and
Robert A. Perkinson and
Andrej Shevchenko and
Matthias Mann and
Gideon Dreyfuss Gemin3 . . . . . . . . . . . . . . . . . 1181
Atsushi Yamaguchi and
Osamu Hori and
David M. Stern and
Enno Hartmann and
Satoshi Ogawa and
Masaya Tohyama Stress-Associated Endoplasmic Reticulum
Protein 1 (Serp1)/Ribosome-Associated
Membrane Protein 4 (Ramp4) Stabilizes
Membrane Proteins during Stress and
Facilitates Subsequent Glycosylation . . 1195
Cecilia Alvarez and
Hideaki Fujita and
Ann Hubbard and
Elizabeth Sztul ER to Golgi Transport . . . . . . . . . 1205
Chih-Ying Chen and
Michael F. Ingram and
Peter H. Rosal and
Todd R. Graham Role for Drs2p, a P--Type Atpase and
Potential Aminophospholipid Translocase,
in Yeast Late Golgi Function . . . . . . 1223
Tracy L. Adair-Kirk and
Kathleen H. Cox and
John V. Cox Intracellular Trafficking of Variant
Chicken Kidney Ae1 Anion Exchangers . . 1237
Elaine A. Neale and
Linda M. Bowers and
Min Jia and
Karen E. Bateman and
Lura C. Williamson Botulinum Neurotoxin a Blocks Synaptic
Vesicle Exocytosis but Not Endocytosis
at the Nerve Terminal . . . . . . . . . 1249
Shuo Ma and
Leda Triviños-Lagos and
Ralph Gräf and
Rex L. Chisholm Dynein Intermediate Chain Mediated
Dynein--Dynactin Interaction Is Required
for Interphase Microtubule Organization
and Centrosome Replication and
Separation in \bionameDictyostelium . . 1261
Conrad L. Leung and
Dongming Sun and
Min Zheng and
David R. Knowles and
Ronald K. H. Liem Microtubule Actin Cross--Linking Factor
(Macf) . . . . . . . . . . . . . . . . . 1275
Marilyn C. Hart and
John A. Cooper Vertebrate Isoforms of Actin Capping
Protein $ \beta $ Have Distinct
Functions in Vivo . . . . . . . . . . . 1287
Joseph E. Italiano and
Patrick Lecine and
Ramesh A. Shivdasani and
John H. Hartwig Blood Platelets Are Assembled
Principally at the Ends of Proplatelet
Processes Produced by Differentiated
Megakaryocytes . . . . . . . . . . . . . 1299
Catherine G. Galbraith and
Michael P. Sheetz Keratocytes Pull with Similar Forces on
Their Dorsal and Ventral Surfaces . . . 1313
Clotilde Gimond and
Arjan van der Flier and
Sanne van Delft and
Cord Brakebusch and
Ingrid Kuikman and
John G. Collard and
Reinhard Fässler and
Arnoud Sonnenberg Induction of Cell Scattering by
Expression of $ \beta $1 Integrins in $
\beta $1-Deficient Epithelial Cells
Requires Activation of Members of the
Rho Family of Gtpases and Downregulation
of Cadherin and Catenin Function . . . . 1325
Nand K. Relan and
Yan Yang and
Safedin Beqaj and
Jeffrey H. Miner and
Lucia Schuger Cell Elongation Induces Laminin $ \alpha
$2 Chain Expression in Mouse Embryonic
Mesenchymal Cells . . . . . . . . . . . 1341
Masahiko Itoh and
Mikio Furuse and
Kazumasa Morita and
Koji Kubota and
Mitinori Saitou and
Shoichiro Tsukita Direct Binding of Three Tight
Junction--Associated Maguks, Zo-1, Zo-2,
and Zo-3, with the Cooh Termini of
Claudins . . . . . . . . . . . . . . . . 1351
Jan P. Tuckermann and
Holger M. Reichardt and
Rosa Arribas and
K. Hartmut Richter and
Günther Schütz and
Peter Angel The DNA Binding--Independent Function of
the Glucocorticoid Receptor Mediates
Repression of Ap-1--Dependent Genes in
Skin . . . . . . . . . . . . . . . . . . 1365
Smruti J. Vidwans and
Mei Lie Wong and
Patrick H. O'Farrell Mitotic Regulators Govern Progress
through Steps in the Centrosome
Duplication Cycle . . . . . . . . . . . 1371
Margherita Doria and
Anna Elisabetta Salcini and
Emanuela Colombo and
Tristram G. Parslow and
Pier Giuseppe Pelicci and
Pier Paolo Di Fiore The Eps15 Homology (Eh) Domain--Based
Interaction between Eps15 and Hrb
Connects the Molecular Machinery of
Endocytosis to That of Nucleocytosolic
Transport . . . . . . . . . . . . . . . 1379
Thomas Wendt and
Dianne Taylor and
Terri Messier and
Kathleen M. Trybus and
Kenneth A. Taylor Visualization of Head--Head Interactions
in the Inhibited State of Smooth Muscle
Myosin . . . . . . . . . . . . . . . . . 1385
Ji Li and
Richard Mayne and
Chuanyue Wu A Novel Muscle--Specific $ \beta $1
Integrin Binding Protein (Mibp) That
Modulates Myogenic Differentiation . . . 1391
Jacqueline E. Mermoud and
Carl Costanzi and
John R. Pehrson and
Neil Brockdorff Histone Macroh2a1.2 Relocates to the
Inactive X Chromosome after Initiation
and Propagation of X--Inactivation . . . 1399
Klara Weipoltshammer and
Christian Schöfer and
Marlene Almeder and
Vlada V. Philimonenko and
Klemens Frei and
Franz Wachtler and
Pavel Hozák Intranuclear Anchoring of Repetitive DNA
Sequences . . . . . . . . . . . . . . . 1409
Masamichi Shiraga and
Alec Ritchie and
Sallouha Aidoudi and
Veronique Baron and
David Wilcox and
Gilbert White and
Belen Ybarrondo and
George Murphy and
Andrew Leavitt and
Sanford Shattil Primary Megakaryocytes Reveal a Role for
Transcription Factor Nf--E2 in Integrin
$ \alpha $ iib$ \beta $3 Signaling . . . 1419
Nancy L. Kedersha and
Mita Gupta and
Wei Li and
Ira Miller and
Paul Anderson RNA-Binding Proteins Tia-1 and Tiar Link
the Phosphorylation of Eif-2$ \alpha $
to the Assembly of Mammalian Stress
Granules . . . . . . . . . . . . . . . . 1431
Pauline Gillece and
José Manuel Luz and
William J. Lennarz and
Francisco Javier de la Cruz and
Karin Römisch Export of a Cysteine--Free Misfolded
Secretory Protein from the Endoplasmic
Reticulum for Degradation Requires
Interaction with Protein Disulfide
Isomerase . . . . . . . . . . . . . . . 1443
Chung-Chih Lin and
Harold D. Love and
Jennifer N. Gushue and
John J. M. Bergeron and
Joachim Ostermann ER\slash Golgi Intermediates Acquire
Golgi Enzymes by Brefeldin a--Sensitive
Retrograde Transport in Vitro . . . . . 1457
Miyuki Nishi and
Shinji Komazaki and
Nagomi Kurebayashi and
Yasuo Ogawa and
Tetsuo Noda and
Masamitsu Iino and
Hiroshi Takeshima Abnormal Features in Skeletal Muscle
from Mice Lacking Mitsugumin29 . . . . . 1473
Kevin W. Trotter and
Iain D. C. Fraser and
Gregory K. Scott and
M. Jackson Stutts and
John D. Scott and
Sharon L. Milgram Alternative Splicing Regulates the
Subcellular Localization of a--Kinase
Anchoring Protein 18 Isoforms . . . . . 1481
Manuel K. A. Bauer and
Alexis Schubert and
Oliver Rocks and
Stefan Grimm Adenine Nucleotide Translocase-1, a
Component of the Permeability Transition
Pore, Can Dominantly Induce Apoptosis 1493
Åsa E. Y. Engqvist-Goldstein and
Michael M. Kessels and
Vikramjit S. Chopra and
Michael R. Hayden and
David G. Drubin An Actin-Binding Protein of the
Sla2/Huntingtin Interacting Protein 1
Family Is a Novel Component of
Clathrin-Coated Pits and Vesicles . . . 1503
Tomoyuki Sumi and
Kunio Matsumoto and
Yoshimi Takai and
Toshikazu Nakamura Cofilin Phosphorylation and Actin
Cytoskeletal Dynamics Regulated by Rho-
and Cdc42-Activated Lim--Kinase 2 . . . 1519
Vera Lúcia Bonilha and
Silvia C. Finnemann and
Enrique Rodriguez-Boulan Ezrin Promotes Morphogenesis of Apical
Microvilli and Basal Infoldings in
Retinal Pigment Epithelium . . . . . . . 1533
Beth E. Drees and
Katy M. Andrews and
Mary C. Beckerle Molecular Dissection of Zyxin Function
Reveals Its Involvement in Cell Motility 1549
Lila R. Collins and
William A. Ricketts and
Linda Yeh and
David Cheresh Bifurcation of Cell Migratory and
Proliferative Signaling by the Adaptor
Protein Shc . . . . . . . . . . . . . . 1561
Michelangelo Cordenonsi and
Fabio D'Atri and
Eva Hammar and
David A. D. Parry and
John Kendrick-Jones and
David Shore and
Sandra Citi Cingulin Contains Globular and
Coiled--Coil Domains and Interacts with
Zo-1, Zo-2, Zo-3, and Myosin . . . . . . 1569