Last update:
Thu Nov 3 12:11:27 MDT 2022
William A. Wells In Brief . . . . . . . . . . . . . . . . ??
Ira Mellman A New Year's Letter from The Editor . . ??
David J. DeRosier and
Lewis G. Tilney F-Actin Bundles Are Derivatives of
Microvilli . . . . . . . . . . . . . . . 1
Michael P. Czubryt and
J. Alejandro Austria and
Grant N. Pierce Hydrogen Peroxide Inhibition of Nuclear
Protein Import Is Mediated by the
Mitogen--Activated Protein Kinase, Erk2 7
Thomas Machleidt and
Wei-Ping Li and
Pingsheng Liu and
Richard G. W. Anderson Multiple Domains in Caveolin-1 Control
Its Intracellular Traffic . . . . . . . 17
Vladimir I. Titorenko and
Honey Chan and
Richard A. Rachubinski Fusion of Small Peroxisomal Vesicles in
Vitro Reconstructs an Early Step in the
in Vivo Multistep Peroxisome Assembly
Pathway of Yarrowia lipolytica . . . . . 29
Roman S. Polishchuk and
Elena V. Polishchuk and
Pierfrancesco Marra and
Saverio Alberti and
Roberto Buccione and
Alberto Luini and
Alexander A. Mironov Correlative Light--Electron Microscopy
Reveals the Tubular--Saccular
Ultrastructure of Carriers Operating
between Golgi Apparatus and Plasma
Membrane . . . . . . . . . . . . . . . . 45
Kevin J. Harvey and
Dunja Lukovic and
David S. Ucker Caspase-Dependent Cdk Activity Is a
Requisite Effector of Apoptotic Death
Events . . . . . . . . . . . . . . . . . 59
Monique A. Lorson and
H. Robert Horvitz and
Sander van den Heuvel LIN-5 Is a Novel Component of the
Spindle Apparatus Required for
Chromosome Segregation and Cleavage
Plane Specification in
\bionameCaenorhabditis elegans . . . . . 73
Lewis G. Tilney and
Patricia S. Connelly and
Kelly A. Vranich and
Michael K. Shaw and
Gregory M. Guild Regulation of Actin Filament
Cross-linking and Bundle Shape in
\bionameDrosophila Bristles . . . . . . 87
Satoko Hakeda and
Sachiko Endo and
Kaoru Saigo Requirements of Kettin, a Giant Muscle
Protein Highly Conserved in Overall
Structure in Evolution, for Normal
Muscle Function, Viability, and Flight
Activity of \bionameDrosophila . . . . . 101
Terri G. Thompson and
Yiu-Mo Chan and
Andrew A. Hack and
Melissa Brosius and
Michael Rajala and
Hart G. W. Lidov and
Elizabeth M. McNally and
Simon Watkins and
Louis M. Kunkel Filamin 2 (FLN2): a Muscle-specific
Sarcoglycan Interacting Protein . . . . 115
Drazen Raucher and
Michael P. Sheetz Cell Spreading and Lamellipodial
Extension Rate Is Regulated by Membrane
Tension . . . . . . . . . . . . . . . . 127
Michael A. McCloskey and
Lei Zhang Potentiation of Fc$ \epsilon $ Receptor
I-activated Ca$^{2+}$ Current (I$_{\rm
CRAC}$) by Cholera Toxin: Possible
Mediation by ADP Ribosylation Factor . . 137
Amanda M. Tiffany and
Louis N. Manganas and
Eunjoon Kim and
Yi-Ping Hsueh and
Morgan Sheng and
James S. Trimmer PSD-95 and SAP97 Exhibit Distinct
Mechanisms for Regulating K$^+$ Channel
Surface Expression and Clustering . . . 147
Alaa E. El-Husseini and
Sarah E. Craven and
Dane M. Chetkovich and
Bonnie L. Firestein and
Eric Schnell and
Chiye Aoki and
David S. Bredt Dual Palmitoylation of Psd-95 Mediates
Its Vesiculotubular Sorting,
Postsynaptic Targeting, and Ion Channel
Clustering . . . . . . . . . . . . . . . 159
Andreas Eger and
Andreas Stockinger and
Birgit Schaffhauser and
Hartmut Beug and
Roland Foisner Epithelial Mesenchymal Transition by
c-Fos Estrogen Receptor Activation
Involves Nuclear Translocation of $
\beta $-Catenin and Upregulation of $
\beta $-Catenin/Lymphoid Enhancer
Binding Factor-1 Transcriptional
Activity . . . . . . . . . . . . . . . . 173
Molly A. Thoreson and
Panos Z. Anastasiadis and
Juliet M. Daniel and
Reneé C. Ireton and
Margaret J. Wheelock and
Keith R. Johnson and
Diana K. Hummingbird and
Albert B. Reynolds Selective Uncoupling of P120$^{\rm ctn}$
from E--Cadherin Disrupts Strong
Adhesion . . . . . . . . . . . . . . . . 189
Jennifer R. Allport and
William A. Muller and
Francis W. Luscinskas Monocytes Induce Reversible Focal
Changes in Vascular Endothelial Cadherin
Complex during Transendothelial
Migration under Flow . . . . . . . . . . 203
Laura M. Machesky The Tails of Two Myosins . . . . . . . . 219
Patrik Ernfors Nuclear Factor-$ \kappa $ b to the
Rescue of Cytokine--Induced Neuronal
Survival . . . . . . . . . . . . . . . . 223
Arthur D. Lander and
Scott B. Selleck The Elusive Functions of Proteoglycans 227
Enrique Martinez-Perez and
Peter J. Shaw and
Graham Moore Polyploidy Induces Centromere
Association . . . . . . . . . . . . . . 233
Josée Dostie and
Flavio Lejbkowicz and
Nahum Sonenberg Nuclear Eukaryotic Initiation Factor 4e
(Eif4e) Colocalizes with Splicing
Factors in Speckles . . . . . . . . . . 239
Bin Yang and
Martin Steegmaier and
Lino C. Gonzalez and
Richard H. Scheller Nsec1 Binds a Closed Conformation of
Syntaxin1a . . . . . . . . . . . . . . . 247
Kathleen L. O'Connor and
Bao-Kim Nguyen and
Arthur M. Mercurio Rhoa Function in Lamellae Formation and
Migration Is Regulated by the $ \alpha
$6$ \beta $4 Integrin and Camp
Metabolism . . . . . . . . . . . . . . . 253
Valentina Sirri and
Pascal Roussel and
Dani\`ele Hernandez-Verdun In Vivo Release of Mitotic Silencing of
Ribosomal Gene Transcription Does Not
Give Rise to Precursor Ribosomal RNA
Processing . . . . . . . . . . . . . . . 259
Francesc Miralles and
Lars-Göran Öfverstedt and
Nafiseh Sabri and
Youssef Aissouni and
Ulf Hellman and
Ulf Skoglund and
Neus Visa Electron Tomography Reveals
Posttranscriptional Binding of
Pre--Mrnps to Specific Fibers in the
Nucleoplasm . . . . . . . . . . . . . . 271
François-Michel Boisvert and
Michael J. Hendzel and
David P. Bazett-Jones Promyelocytic Leukemia (Pml) Nuclear
Bodies Are Protein Structures That Do
Not Accumulate RNA . . . . . . . . . . . 283
Martin Hetzer and
Iain W. Mattaj An ATP--Dependent, Ran--Independent
Mechanism for Nuclear Import of the U1a
and U2b'' Spliceosome Proteins . . . . . 293
Florencia Schapiro and
Jason Sparkowski and
Alex Adduci and
Frank Suprynowicz and
Richard Schlegel and
Sergio Grinstein Golgi Alkalinization by the
Papillomavirus E5 Oncoprotein . . . . . 305
Julia Avery and
Darren J. Ellis and
Thorsten Lang and
Phillip Holroyd and
Dietmar Riedel and
Robert M. Henderson and
J. Michael Edwardson and
Reinhard Jahn A Cell--Free System for Regulated
Exocytosis in Pc12 Cells . . . . . . . . 317
Gayle Middleton and
Makoto Hamanoue and
Yasushi Enokido and
Sean Wyatt and
Diane Pennica and
Ellis Jaffray and
Ronald T. Hay and
Alun M. Davies Cytokine-Induced Nuclear Factor Kappa B
Activation Promotes the Survival of
Developing Neurons . . . . . . . . . . . 325
Tsuyoshi Miyazaki and
Hideki Katagiri and
Yumi Kanegae and
Hiroshi Takayanagi and
Yasuhiro Sawada and
Aiichiro Yamamoto and
Mattew P. Pando and
Tomoichiro Asano and
Inder M. Verma and
Hiromi Oda and
Kozo Nakamura and
Sakae Tanaka Reciprocal Role of ERK and Nf-$ \kappa $
b Pathways in Survival and Activation of
Osteoclasts . . . . . . . . . . . . . . 333
Connie Myers and
Aubri Charboneau and
Nancy Boudreau Homeobox B3 Promotes Capillary
Morphogenesis and Angiogenesis . . . . . 343
Marie Evangelista and
Bert M. Klebl and
Amy H. Y. Tong and
Bradley A. Webb and
Thomas Leeuw and
Ekkehard Leberer and
Malcolm Whiteway and
David Y. Thomas and
Charles Boone A Role for Myosin-I in Actin Assembly
through Interactions with Vrp1p, Bee1p,
and the Arp2/3 Complex . . . . . . . . . 353
Terry Lechler and
Anna Shevchenko and
Andrej Shevchenko and
Rong Li Direct Involvement of Yeast Type I
Myosins in Cdc42-Dependent Actin
Polymerization . . . . . . . . . . . . . 363
Wanyuan Ao and
Dave Pilgrim \bionameCaenorhabditis elegans Unc-45 Is
a Component of Muscle Thick Filaments
and Colocalizes with Myosin Heavy Chain
B, but Not Myosin Heavy Chain A . . . . 375
Kathryn S. R. Spencer and
Diana Graus-Porta and
Jie Leng and
Nancy E. Hynes and
Richard L. Klemke ErbB2 Is Necessary for Induction of
Carcinoma Cell Invasion by Erbb Family
Receptor Tyrosine Kinases . . . . . . . 385
Barry M. Gumbiner Regulation of Cadherin Adhesive Activity 399
Sandrine Middendorp and
Thomas Küntziger and
Yann Abraham and
Simon Holmes and
Nicole Bordes and
Michel Paintrand and
Anne Paoletti and
Michel Bornens A Role for Centrin 3 in Centrosome
Reproduction . . . . . . . . . . . . . . 405
Hengjiang Dong and
G. Shirleen Roeder Organization of the Yeast Zip1 Protein
within the Central Region of the
Synaptonemal Complex . . . . . . . . . . 417
James E. Wilhelm and
Jennifer Mansfield and
Nora Hom-Booher and
Shengxian Wang and
Christoph W. Turck and
Tulle Hazelrigg and
Ronald D. Vale Isolation of a Ribonucleoprotein Complex
Involved in mRNA Localization in
\bionameDrosophila Oocytes . . . . . . . 427
Marisa Segal and
Duncan J. Clarke and
Paul Maddox and
E. D. Salmon and
Kerry Bloom and
Steven I. Reed Coordinated Spindle Assembly and
Orientation Requires Clb5p--Dependent
Kinase in Budding Yeast . . . . . . . . 441
Kiminori Toyooka and
Takashi Okamoto and
Takao Minamikawa Mass Transport of Proform of a
Kdel--Tailed Cysteine Proteinase
(Sh--EP) to Protein Storage Vacuoles by
Endoplasmic Reticulum--Derived Vesicle
Is Involved in Protein Mobilization in
Germinating Seeds . . . . . . . . . . . 453
Takeshi Noda and
John Kim and
Wei-Pang Huang and
Misuzu Baba and
Chikara Tokunaga and
Yoshinori Ohsumi and
Daniel J. Klionsky Apg9p\slash Cvt7p Is an Integral
Membrane Protein Required for Transport
Vesicle Formation in the Cvt and
Autophagy Pathways . . . . . . . . . . . 465
Elizabeth Hong-Geller and
Richard A. Cerione Cdc42 and Rac Stimulate Exocytosis of
Secretory Granules by Activating the
Ip$_3$ /Calcium Pathway in Rbl-2h3 Mast
Cells . . . . . . . . . . . . . . . . . 481
Jennifer R. Henkel and
Gregory A. Gibson and
Paul A. Poland and
Mark A. Ellis and
Rebecca P. Hughey and
Ora A. Weisz Influenza M2 Proton Channel Activity
Selectively Inhibits Trans-Golgi Network
Release of Apical Membrane and Secreted
Proteins in Polarized Madin--Darby
Canine Kidney Cells . . . . . . . . . . 495
Yuko Mimori-Kiyosue and
Nobuyuki Shiina and
Shoichiro Tsukita Adenomatous Polyposis Coli (APC) Protein
Moves along Microtubules and
Concentrates at Their Growing Ends in
Epithelial Cells . . . . . . . . . . . . 505
Jack Taunton and
Brian A. Rowning and
Margaret L. Coughlin and
Michael Wu and
Randall T. Moon and
Timothy J. Mitchison and
Carolyn A. Larabell Actin-Dependent Propulsion of Endosomes
and Lysosomes by Recruitment of N-Wasp 519
Amanda Y. Chan and
Maryse Bailly and
Noureddine Zebda and
Jeffrey E. Segall and
John S. Condeelis Role of Cofilin in Epidermal Growth
Factor--Stimulated Actin Polymerization
and Lamellipod Protrusion . . . . . . . 531
Marc J. Servant and
Philippe Coulombe and
Benjamin Turgeon and
Sylvain Meloche Differential Regulation of P27$^{\rm
Kip1}$ Expression by Mitogenic and
Hypertrophic Factors . . . . . . . . . . 543
Hirotaka Kazama and
Shin Yonehara Oncogenic K--Ras and Basic Fibroblast
Growth Factor Prevent FAS-Mediated
Apoptosis in Fibroblasts through
Activation of Mitogen-Activated Protein
Kinase . . . . . . . . . . . . . . . . . 557
Joerg Huelsken and
Regina Vogel and
Volker Brinkmann and
Bettina Erdmann and
Carmen Birchmeier and
Walter Birchmeier Requirement for $ \beta $-Catenin in
Anterior--Posterior Axis Formation in
Mice . . . . . . . . . . . . . . . . . . 567
Wei-Song Shan and
Hidekazu Tanaka and
Greg R. Phillips and
Kirsten Arndt and
Mika Yoshida and
David R. Colman and
Lawrence Shapiro Functional Cis--Heterodimers of N- and
R--Cadherins . . . . . . . . . . . . . . 579
Wen Shi and
Huizhou Fan and
Lillian Shum and
Rik Derynck The Tetraspanin Cd9 Associates with
Transmembrane TGF-$ \alpha $ and
Regulates TGF-$ \alpha $-Induced Egf
Receptor Activation and Cell
Proliferation . . . . . . . . . . . . . 591
Adam Zweifach Target-Cell Contact Activates a Highly
Selective Capacitative Calcium Entry
Pathway in Cytotoxic T Lymphocytes . . . 603
Naohiko Koshikawa and
Gianluigi Giannelli and
Vincenzo Cirulli and
Kaoru Miyazaki and
Vito Quaranta Role of Cell Surface Metalloprotease
Mt1-Mmp in Epithelial Cell Migration
over Laminin-5 . . . . . . . . . . . . . 615
Po Chen and
John M. Abrams Drosophila Apoptosis and Bcl-2 Genes . . 625
Wolfgang Mayer and
Avril Smith and
Reinald Fundele and
Thomas Haaf Spatial Separation of Parental Genomes
in Preimplantation Mouse Embryos . . . . 629
Michael P. Rout and
John D. Aitchison and
Adisetyantari Suprapto and
Kelly Hjertaas and
Yingming Zhao and
Brian T. Chait The Yeast Nuclear Pore Complex . . . . . 635
Tsuyoshi Okagaki and
Akio Nakamura and
Tomohiko Suzuki and
Kazuhiro Ohmi and
Kazuhiro Kohama Assembly of Smooth Muscle Myosin by the
38k Protein, a Homologue of a Subunit of
Pre-mRNA Splicing Factor-2 . . . . . . . 653
Meenakshi Chellaiah and
Neil Kizer and
Matthew Silva and
Ulises Alvarez and
David Kwiatkowski and
Keith A. Hruska Gelsolin Deficiency Blocks Podosome
Assembly and Produces Increased Bone
Mass and Strength . . . . . . . . . . . 665
Andrea D. Weston and
Vicki Rosen and
Roshantha A. S. Chandraratna and
T. Michael Underhill Regulation of Skeletal Progenitor
Differentiation by the Bmp and Retinoid
Signaling Pathways . . . . . . . . . . . 679
Gist H. Farr and
Denise M. Ferkey and
Cynthia Yost and
Sarah B. Pierce and
Carole Weaver and
David Kimelman Interaction among Gsk-3, Gbp, Axin, and
APC in \bionameXenopus Axis
Specification . . . . . . . . . . . . . 691
Paul A. Colussi and
Leonie M. Quinn and
David C. S. Huang and
Michelle Coombe and
Stuart H. Read and
Helena Richardson and
Sharad Kumar Debcl, a Proapoptotic Bcl-2 Homologue,
Is a Component of the \bionameDrosophila
melanogaster Cell Death Machinery . . . 703
Rainer Pepperkok and
Agnes Hotz-Wagenblatt and
Norbert König and
Andreas Girod and
Dirk Bossemeyer and
Volker Kinzel Intracellular Distribution of Mammalian
Protein Kinase a Catalytic Subunit
Altered by Conserved Asn2 Deamidation 715
Paul Verkade and
Thomas Harder and
Frank Lafont and
Kai Simons Induction of Caveolae in the Apical
Plasma Membrane of Madin--Darby Canine
Kidney Cells . . . . . . . . . . . . . . 727
Konark Mukherjee and
Shadab A. Siddiqi and
Shehla Hashim and
Manoj Raje and
Sandip K. Basu and
Amitabha Mukhopadhyay Live Salmonella Recruits N
--Ethylmaleimide--Sensitive Fusion
Protein on Phagosomal Membrane and
Promotes Fusion with Early Endosome . . 741
Robert M. Smith and
Boris Baibakov and
Yoshihide Ikebuchi and
Benjamin H. White and
Nevin A. Lambert and
Leonard K. Kaczmarek and
Steven S. Vogel Exocytotic Insertion of Calcium Channels
Constrains Compensatory Endocytosis to
Sites of Exocytosis . . . . . . . . . . 755
Lisa A. Dunbar and
Paul Aronson and
Michael J. Caplan A Transmembrane Segment Determines the
Steady--State Localization of an
Ion--Transporting Adenosine
Triphosphatase . . . . . . . . . . . . . 769
Rachel B. Hazan and
Greg R. Phillips and
Rui Fang Qiao and
Larry Norton and
Stuart A. Aaronson Exogenous Expression of N--Cadherin in
Breast Cancer Cells Induces Cell
Migration, Invasion, and Metastasis . . 779
Danxi Li and
Randall J. Mrsny Oncogenic Raf-1 Disrupts Epithelial
Tight Junctions via Downregulation of
Occludin . . . . . . . . . . . . . . . . 791
Mark A. Bowe and
Duane B. Mendis and
Justin R. Fallon The Small Leucine--Rich Repeat
Proteoglycan Biglycan Binds to $ \alpha
$-Dystroglycan and Is Upregulated in
Dystrophic Muscle . . . . . . . . . . . 801
Marilyn L. Fitzgerald and
Zihua Wang and
Pyong Woo Park and
Gillian Murphy and
Merton Bernfield Shedding of Syndecan-1 and -4
Ectodomains Is Regulated by Multiple
Signaling Pathways and Mediated by a
Timp-3--Sensitive Metalloproteinase . . 811
Sergey S. Akimov and
Dmitry Krylov and
Laurie F. Fleischman and
Alexey M. Belkin Tissue Transglutaminase Is an
Integrin--Binding Adhesion Coreceptor
for Fibronectin . . . . . . . . . . . . 825
Mark Noble Precursor Cell Transitions in
Oligodendrocyte Development . . . . . . 839
Sergei N. Prokopenko and
Robert Saint and
Hugo J. Bellen Untying the Gordian Knot of Cytokinesis 843
Makoto Adachi and
Makoto Fukuda and
Eisuke Nishida Nuclear Export of Map Kinase (ERK)
Involves a Map Kinase Kinase
(Mek--Dependent) Active Transport
Mechanism . . . . . . . . . . . . . . . 849
Paolo Pinton and
Davide Ferrari and
Paulo Magalhães and
Klaus Schulze-Osthoff and
Francesco Di Virgilio and
Tullio Pozzan and
Rosario Rizzuto Reduced Loading of Intracellular
Ca$^{2+}$ Stores and Downregulation of
Capacitative Ca$^{2+}$ Influx in
Bcl-2--Overexpressing Cells . . . . . . 857
Yu Chen and
Sanford M. Simon In Situ Biochemical Demonstration That
P--Glycoprotein Is a Drug Efflux Pump
with Broad Specificity . . . . . . . . . 863
Kevin G. Hardwick and
Raymond C. Johnston and
Dana L. Smith and
Andrew W. Murray MAD3 Encodes a Novel Component of the
Spindle Checkpoint Which Interacts with
Bub3p, Cdc20p, and Mad2p . . . . . . . . 871
Lars Dreier and
Tom A. Rapoport In Vitro Formation of the Endoplasmic
Reticulum Occurs Independently of
Microtubules by a Controlled Fusion
Reaction . . . . . . . . . . . . . . . . 883
Emanuela Pedrazzini and
Antonello Villa and
Renato Longhi and
Alessandra Bulbarelli and
Nica Borgese Mechanism of Residence of Cytochrome
B(5), a Tail--Anchored Protein, in the
Endoplasmic Reticulum . . . . . . . . . 899
Stephen R. Cronin and
Afif Khoury and
Dana K. Ferry and
Randolph Y. Hampton Regulation of HMG--Coa Reductase
Degradation Requires the P-Type ATPase
Cod1p/Spf1p . . . . . . . . . . . . . . 915
Manuel Muñiz and
Claude Nuoffer and
Hans-Peter Hauri and
Howard Riezman The Emp24 Complex Recruits a Specific
Cargo Molecule into Endoplasmic
Reticulum--Derived Vesicles . . . . . . 925
Katherine A. Sacksteder and
Jacob M. Jones and
Sarah T. South and
Xiaoling Li and
Yifei Liu and
Stephen J. Gould Pex19 Binds Multiple Peroxisomal
Membrane Proteins, Is Predominantly
Cytoplasmic, and Is Required for
Peroxisome Membrane Synthesis . . . . . 931
Steven P. Gross and
Michael A. Welte and
Steven M. Block and
Eric F. Wieschaus Dynein-Mediated Cargo Transport in Vivo 945
Valérie Petit and
Brigitte Boyer and
Delphine Lentz and
Christopher E. Turner and
Jean Paul Thiery and
Ana M. Vallés Phosphorylation of Tyrosine Residues 31
and 118 on Paxillin Regulates Cell
Migration through an Association with
Crk in Nbt--II Cells . . . . . . . . . . 957
Dean G. Tang and
Yasuhito M. Tokumoto and
Martin C. Raff Long-Term Culture of Purified Postnatal
Oligodendrocyte Precursor Cells . . . . 971
Q. L. Lu and
G. E. Morris and
S. D. Wilton and
T. Ly and
O. V. Artem'yeva and
P. Strong and
T. A. Partridge Massive Idiosyncratic Exon Skipping
Corrects the Nonsense Mutation in
Dystrophic Mouse Muscle and Produces
Functional Revertant Fibers by Clonal
Expansion . . . . . . . . . . . . . . . 985
A. Pralle and
P. Keller and
E.-L. Florin and
K. Simons and
J. K. H. Hörber Sphingolipid--Cholesterol Rafts Diffuse
as Small Entities in the Plasma Membrane
of Mammalian Cells . . . . . . . . . . . 997
X. Yin and
G. J. Kidd and
L. Wrabetz and
M. L. Feltri and
A. Messing and
B. D. Trapp Schwann Cell Myelination Requires Timely
and Precise Targeting of P$_0$ Protein 1009
Lawrence Wrabetz and
Maria Laura Feltri and
Angelo Quattrini and
Daniele Imperiale and
Stefano Previtali and
Maurizio D'Antonio and
Rudolf Martini and
Xinghua Yin and
Bruce D. Trapp and
Lei Zhou and
Shing-Yan Chiu and
Albee Messing P$_0$ Glycoprotein Overexpression Causes
Congenital Hypomyelination of Peripheral
Nerves . . . . . . . . . . . . . . . . . 1021
Alistair N. Garratt and
Octavian Voiculescu and
Piotr Topilko and
Patrick Charnay and
Carmen Birchmeier A Dual Role of erbB2 in Myelination and
in Expansion of the Schwann Cell
Precursor Pool . . . . . . . . . . . . . 1035
Britta Qualmann and
Regis B. Kelly Syndapin Isoforms Participate in
Receptor-Mediated Endocytosis and Actin
Organization . . . . . . . . . . . . . . 1047
Arjan Pieter Quist and
Seung Keun Rhee and
Hai Lin and
Ratneshwar Lal Physiological Role of Gap--Junctional
Hemichannels . . . . . . . . . . . . . . 1063
Roumen Pankov and
Edna Cukierman and
Ben-Zion Katz and
Kazue Matsumoto and
Diane C. Lin and
Shin Lin and
Cornelia Hahn and
Kenneth M. Yamada Integrin Dynamics and Matrix Assembly 1075
Thoru Pederson and
Joan C. Politz The Nucleolus and the Four
Ribonucleoproteins of Translation . . . 1091
N. Ronald Morris Nuclear Migration . . . . . . . . . . . 1097
Harold P. Erickson Dynamin and Ftsz . . . . . . . . . . . . 1103
Roberto Giordano and
Anna Rosa Magnano and
Germana Zaccagnini and
Carmine Pittoggi and
Nicola Moscufo and
Rodolfo Lorenzini and
Corrado Spadafora Reverse Transcriptase Activity in Mature
Spermatozoa of Mouse . . . . . . . . . . 1107
Aljoscha Nern and
Robert A. Arkowitz Nucleocytoplasmic Shuttling of the
Cdc42p Exchange Factor Cdc24p . . . . . 1115
E. Sergio Trombetta and
Ari Helenius Conformational Requirements for
Glycoprotein Reglucosylation in the
Endoplasmic Reticulum . . . . . . . . . 1123
Chantal Guiet and
Pasquale Vito Caspase Recruitment Domain
(Card--Dependent) Cytoplasmic Filaments
Mediate Bcl10-Induced Nf-$ \kappa $ b
Activation . . . . . . . . . . . . . . . 1131
Iñigo Martinez and
Sabyasachi Chakrabarti and
Turid Hellevik and
Jennifer Morehead and
Kimberly Fowler and
Norma W. Andrews Synaptotagmin VII Regulates Ca$^{2+}$
-Dependent Exocytosis of Lysosomes in
Fibroblasts . . . . . . . . . . . . . . 1141
Kris A. Reedquist and
Ewan Ross and
Elianne A. Koop and
Rob M. F. Wolthuis and
Fried J. T. Zwartkruis and
Yvette van Kooyk and
Mike Salmon and
Christopher D. Buckley and
Johannes L. Bos The Small Gtpase, Rap1, Mediates
Cd31-Induced Integrin Adhesion . . . . . 1151
Snezhana Oliferenko and
Irina Kaverina and
J. Victor Small and
Lukas A. Huber Hyaluronic Acid (Ha) Binding to Cd44
Activates Rac1 and Induces Lamellipodia
Outgrowth . . . . . . . . . . . . . . . 1159
Sirpa Aho and
Monique Buisson and
Tiina Pajunen and
Young W. Ryoo and
Jean-François Giot and
Henry Gruffat and
Alain Sergeant and
Jouni Uitto Ubinuclein, a Novel Nuclear Protein
Interacting with Cellular and Viral
Transcription Factors . . . . . . . . . 1165
Bernard Charroux and
Livio Pellizzoni and
Robert A. Perkinson and
Jeongsik Yong and
Andrej Shevchenko and
Matthias Mann and
Gideon Dreyfuss Gemin4 . . . . . . . . . . . . . . . . . 1177
R. Montgomery Gill and
Paul A. Hamel Subcellular Compartmentalization of E2f
Family Members Is Required for
Maintenance of the Postmitotic State in
Terminally Differentiated Muscle . . . . 1187
Anton Schmitz and
Helga Herrgen and
Alexandra Winkeler and
Volker Herzog Cholera Toxin Is Exported from
Microsomes by the Sec61p Complex . . . . 1203
Karen Sohrt and
Jürgen Soll Toc64, a New Component of the Protein
Translocon of Chloroplasts . . . . . . . 1213
Albert Price and
William Wickner and
Christian Ungermann Proteins Needed for Vesicle Budding from
the Golgi Complex Are Also Required for
the Docking Step of Homotypic Vacuole
Fusion . . . . . . . . . . . . . . . . . 1223
Albert Price and
Darren Seals and
William Wickner and
Christian Ungermann The Docking Stage of Yeast Vacuole
Fusion Requires the Transfer of Proteins
from a Cis-Snare Complex to a Rab/Ypt
Protein . . . . . . . . . . . . . . . . 1231
Marion MacFarlane and
Wendy Merrison and
David Dinsdale and
Gerald M. Cohen Active Caspases and Cleaved Cytokeratins
Are Sequestered into Cytoplasmic
Inclusions in Trail--Induced Apoptosis 1239
Sen Takeda and
Hiroto Yamazaki and
Dae-Hyun Seog and
Yoshimitsu Kanai and
Sumio Terada and
Nobutaka Hirokawa Kinesin Superfamily Protein 3 (Kif3)
Motor Transports Fodrin--Associating
Vesicles Important for Neurite Building 1255
K. A. DeFea and
J. Zalevsky and
M. S. Thoma and
O. Déry and
R. D. Mullins and
N. W. Bunnett $ \beta $-Arrestin--Dependent
Endocytosis of Proteinase--Activated
Receptor 2 Is Required for Intracellular
Targeting of Activated Erk1/2 . . . . . 1267
Masayuki Shimizu and
Yasunori Murakami and
Fumikazu Suto and
Hajime Fujisawa Determination of Cell Adhesion Sites of
Neuropilin-1 . . . . . . . . . . . . . . 1283
Yan Ping Wu and
Chia-Jen Siao and
Weiquan Lu and
Tsung-Chang Sung and
Michael A. Frohman and
Peter Milev and
Thomas H. Bugge and
Jay L. Degen and
Joel M. Levine and
Richard U. Margolis and
Stella E. Tsirka The Tissue Plasminogen Activator
(Tpa/Plasmin) Extracellular Proteolytic
System Regulates Seizure-Induced
Hippocampal Mossy Fiber Outgrowth
through a Proteoglycan Substrate . . . . 1295
Yolanda S. López-Boado and
Carole L. Wilson and
Lora V. Hooper and
Jeffrey I. Gordon and
Scott J. Hultgren and
William C. Parks Bacterial Exposure Induces and Activates
Matrilysin in Mucosal Epithelial Cells 1305
Patrick Brennwald Reversal of Fortune . . . . . . . . . . ??
Susan L. Kline-Smith and
Claire E. Walczak Microtubules in orbit . . . . . . . . . 5
Thomas M. Roberts and
Murray Stewart Acting like Actin . . . . . . . . . . . 7
Shoichiro Tsukita and
Mikio Furuse Pores in the Wall . . . . . . . . . . . 13
Carlos Caulin and
Carl F. Ware and
Thomas M. Magin and
Robert G. Oshima Keratin-Dependent, Epithelial Resistance
to Tumor Necrosis Factor--Induced
Apoptosis . . . . . . . . . . . . . . . 17
Jan Schmoranzer and
Mark Goulian and
Dan Axelrod and
Sanford M. Simon Imaging Constitutive Exocytosis with
Total Internal Reflection Fluorescence
Microscopy . . . . . . . . . . . . . . . 23
Derek Toomre and
Jürgen A. Steyer and
Patrick Keller and
Wolfhard Almers and
Kai Simons Fusion of Constitutive Membrane Traffic
with the Cell Surface Observed by
Evanescent Wave Microscopy . . . . . . . 33
Symeon Siniossoglou and
Malik Lutzmann and
Helena Santos-Rosa and
Kevin Leonard and
Shirley Mueller and
Ueli Aebi and
Ed Hurt Structure and Assembly of the Nup84p
Complex . . . . . . . . . . . . . . . . 41
Xiaochun Cao and
Charles Barlowe Asymmetric Requirements for a Rab Gtpase
and Snare Proteins in Fusion of Copii
Vesicles with Acceptor Membranes . . . . 55
Jennifer Hirst and
Winnie W. Y. Lui and
Nicholas A. Bright and
Nicholas Totty and
Matthew N. J. Seaman and
Margaret S. Robinson A Family of Proteins with $ \gamma
$-Adaptin and VHS Domains That
Facilitate Trafficking between the
Trans-Golgi Network and the
Vacuole/Lysosome . . . . . . . . . . . . 67
Esteban C. Dell'Angelica and
Rosa Puertollano and
Chris Mullins and
Rubén C. Aguilar and
José D. Vargas and
Lisa M. Hartnell and
Juan S. Bonifacino Ggas . . . . . . . . . . . . . . . . . . 81
N. Barry Elkind and
Christiane Walch-Solimena and
Peter J. Novick The Role of the COOH Terminus of Sec2p
in the Transport of post-Golgi Vesicles 95
Audra J. Charron and
Sakie Nakamura and
Robert Bacallao and
Angela Wandinger-Ness Compromised Cytoarchitecture and
Polarized Trafficking in Autosomal
Dominant Polycystic Kidney Disease Cells 111
Andrew Bloecher and
Kelly Tatchell Dynamic Localization of Protein
Phosphatase Type 1 in the Mitotic Cell
Cycle of \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 125
Diego Peretti and
Leticia Peris and
Silvana Rosso and
Santiago Quiroga and
Alfredo Cáceres Evidence for the Involvement of Kif4 in
the Anterograde Transport of
L1-Containing Vesicles . . . . . . . . . 141
Yoshihiro H. Inoue and
Maria do Carmo Avides and
Michina Shiraki and
Peter Deak and
Masamitsu Yamaguchi and
Yoshio Nishimoto and
Akio Matsukage and
David M. Glover Orbit, a Novel Microtubule--Associated
Protein Essential for Mitosis in
\bionameDrosophila melanogaster . . . . 153
Isabelle Coppens and
Anthony P. Sinai and
Keith A. Joiner \bionameToxoplasma gondii Exploits Host
Low-Density Lipoprotein
Receptor-Mediated Endocytosis for
Cholesterol Acquisition . . . . . . . . 167
Matthias Krause and
Antonio S. Sechi and
Marlies Konradt and
David Monner and
Frank B. Gertler and
Jürgen Wehland Fyn-Binding Protein
(Fyb)/SLP-76-Associated Protein (SLAP),
Ena/Vasodilator-Stimulated
Phosphoprotein (VASP) Proteins and the
Arp2/3 Complex Link T Cell Receptor
(Tcr) Signaling to the Actin
Cytoskeleton . . . . . . . . . . . . . . 181
Iakowos Karakesisoglou and
Yanmin Yang and
Elaine Fuchs An Epidermal Plakin That Integrates
Actin and Microtubule Networks at
Cellular Junctions . . . . . . . . . . . 195
Mechthild Hatzfeld and
Christof Haffner and
Katrin Schulze and
Ute Vinzens The Function of Plakophilin 1 in
Desmosome Assembly and Actin Filament
Organization . . . . . . . . . . . . . . 209
Samuel Y. Cho and
Richard L. Klemke Extracellular-Regulated Kinase
Activation and CAS/Crk Coupling Regulate
Cell Migration and Suppress Apoptosis
during Invasion of the Extracellular
Matrix . . . . . . . . . . . . . . . . . 223
W. James Nelson W(H)ither the Golgi during Mitosis? . . 243
Ken-Ichi Takemaru and
Randall T. Moon The Transcriptional Coactivator Cbp
Interacts with $ \beta $-Catenin to
Activate Gene Expression . . . . . . . . 249
Matthias Becker and
Elke Martin and
Jean Schneikert and
Harald F. Krug and
Andrew C. B. Cato Cytoplasmic Localization and the Choice
of Ligand Determine Aggregate Formation
by Androgen Receptor with Amplified
Polyglutamine Stretch . . . . . . . . . 255
Siegfried Wahl and
Holger Barth and
Thomas Ciossek and
Klaus Aktories and
Bernhard K. Mueller Ephrin-A5 Induces Collapse of Growth
Cones by Activating Rho and Rho Kinase 263
Heinrich Leonhardt and
Hans-Peter Rahn and
Peter Weinzierl and
Anje Sporbert and
Thomas Cremer and
Daniele Zink and
M. Cristina Cardoso Dynamics of DNA Replication Factories in
Living Cells . . . . . . . . . . . . . . 271
Asoke Mal and
Debasis Chattopadhyay and
Mrinal K. Ghosh and
Randy Y. C. Poon and
Tony Hunter and
Marian L. Harter P21 and Retinoblastoma Protein Control
the Absence of DNA Replication in
Terminally Differentiated Muscle Cells 281
Céline Verheggen and
Genevi\`eve Almouzni and
Dani\`ele Hernandez-Verdun The Ribosomal RNA Processing Machinery
Is Recruited to the Nucleolar Domain
before RNA Polymerase I during
\bionameXenopus laevis Development . . . 293
Willemien van der Houven van Oordt and
María T. Diaz-Meco and
José Lozano and
Adrian R. Krainer and
Jorge Moscat and
Javier F. Cáceres The Mkk$_{3 \slash 6}$-p38-Signaling
Cascade Alters the Subcellular
Distribution of Hnrnp A1 and Modulates
Alternative Splicing Regulation . . . . 307
Matthieu Piel and
Pablo Meyer and
Alexey Khodjakov and
Conly L. Rieder and
Michel Bornens The Respective Contributions of the
Mother and Daughter Centrioles to
Centrosome Activity and Behavior in
Vertebrate Cells . . . . . . . . . . . . 317
Antonino Colanzi and
Thomas J. Deerinck and
Mark H. Ellisman and
Vivek Malhotra A Specific Activation of the
Mitogen--Activated Protein Kinase Kinase
1 (Mek1) Is Required for Golgi
Fragmentation during Mitosis . . . . . . 331
Martin Lowe and
Nicholas K. Gonatas and
Graham Warren The Mitotic Phosphorylation Cycle of the
cis-Golgi Matrix Protein Gm130 . . . . . 341
Fumi Kano and
Katsuya Takenaka and
Akitsugu Yamamoto and
Kuniaki Nagayama and
Eisuke Nishida and
Masayuki Murata Mek and Cdc2 Kinase Are Sequentially
Required for Golgi Disassembly in Mdck
Cells by the Mitotic \bionameXenopus
Extracts . . . . . . . . . . . . . . . . 357
Stephanie Ruf and
Klaus Biehler and
Ralph Bock A Small Chloroplast--Encoded Protein as
a Novel Architectural Component of the
Light--Harvesting Antenna . . . . . . . 369
David E. Krantz and
Clarissa Waites and
Viola Oorschot and
Yongjian Liu and
Rachel I. Wilson and
Philip K. Tan and
Judith Klumperman and
Robert H. Edwards A Phosphorylation Site Regulates Sorting
of the Vesicular Acetylcholine
Transporter to Dense Core Vesicles . . . 379
Andreas Wiederkehr and
Sandrine Avaro and
Cristina Prescianotto-Baschong and
Rosine Haguenauer-Tsapis and
Howard Riezman The F--Box Protein Rcy1p Is Involved in
Endocytic Membrane Traffic and Recycling
Out of an Early Endosome in
\bionameSaccharomyces cerevisiae . . . . 397
Alyson E. Fournier and
Fumio Nakamura and
Susumu Kawamoto and
Yoshio Goshima and
Robert G. Kalb and
Stephen M. Strittmatter Semaphorin3a Enhances Endocytosis at
Sites of Receptor--F--Actin
Colocalization during Growth Cone
Collapse . . . . . . . . . . . . . . . . 411
Hiroki Ueda and
Smita Abbi and
Chuanhai Zheng and
Jun-Lin Guan Suppression of Pyk2 Kinase and Cellular
Activities by Fip200 . . . . . . . . . . 423
Andrew P. Gilmore and
Anthony D. Metcalfe and
Lewis H. Romer and
Charles H. Streuli Integrin-Mediated Survival Signals
Regulate the Apoptotic Function of Bax
through Its Conformation and Subcellular
Localization . . . . . . . . . . . . . . 431
Kirill Rosen and
Janusz Rak and
Thomas Leung and
Nicholas M. Dean and
Robert S. Kerbel and
Jorge Filmus Activated ras Prevents Downregulation of
Bcl--X$_L$ Triggered by Detachment from
the Extracellular Matrix . . . . . . . . 447
Sarang V. Kulkarni and
Gerald Gish and
Peter van der Geer and
Mark Henkemeyer and
Tony Pawson Role of P120 Ras--Gap in Directed Cell
Movement . . . . . . . . . . . . . . . . 457
Daniel P. Kiehart and
Catherine G. Galbraith and
Kevin A. Edwards and
Wayne L. Rickoll and
Ruth A. Montague Multiple Forces Contribute to Cell Sheet
Morphogenesis for Dorsal Closure in
\bionameDrosophila . . . . . . . . . . . 471
Catherine Faivre-Sarrailh and
France Gauthier and
Natalia Denisenko-Nehrbass and
André Le Bivic and
Genevi\`eve Rougon and
Jean-Antoine Girault The Glycosylphosphatidyl
Inositol-Anchored Adhesion Molecule
F3/Contactin Is Required for Surface
Transport of
Paranodin/Contactin-Associated Protein
(Caspr) . . . . . . . . . . . . . . . . 491
Emmanuelle Charpentier and
Robert M. Lavker and
Elizabeth Acquista and
Pamela Cowin Plakoglobin Suppresses Epithelial
Proliferation and Hair Growth in Vivo 503
Sambra D. Redick and
Daniel L. Settles and
Gina Briscoe and
Harold P. Erickson Defining Fibronectin's Cell Adhesion
Synergy Site by Site-Directed
Mutagenesis . . . . . . . . . . . . . . 521
Ira Mellman Quo Vadis: Polarized Membrane Recycling
in Motility and Phagocytosis . . . . . . 529
Rikke Lise Steen and
Fabien Cubizolles and
Katherine Le Guellec and
Philippe Collas A Kinase-Anchoring Protein (Akap95)
Recruits Human Chromosome-Associated
Protein (Hcap--D2/Eg7) for Chromosome
Condensation in Mitotic Extract . . . . 531
Joel Hyman and
Hong Chen and
Pier Paolo Di Fiore and
Pietro De Camilli and
Axel T. Brunger Epsin 1 Undergoes Nucleocytosolic
Shuttling and Its Eps15 Interactor
Nh$_2$ -Terminal Homology (Enth) Domain,
Structurally Similar to Armadillo and
Heat Repeats, Interacts with the
Transcription Factor Promyelocytic
Leukemia Zn$^2$ + Finger Protein (Plzf) 537
Nam-On Ku and
M. Bishr Omary Keratins Turn over by Ubiquitination in
a Phosphorylation--Modulated Fashion . . 547
Soundarapandian Velmurugan and
Xian-Mei Yang and
Clarence S.-M. Chan and
Melanie Dobson and
Makkuni Jayaram Partitioning of the 2-$ \mu $ m Circle
Plasmid of \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 553
Young-Gyu Ko and
Young-Sun Kang and
Eun-Kyoung Kim and
Sang Gyu Park and
Sunghoon Kim Nucleolar Localization of Human
Methionyl--Trna Synthetase and Its Role
in Ribosomal RNA Synthesis . . . . . . . 567
Stephan Fath and
Philipp Milkereit and
Alexandre V. Podtelejnikov and
Nicolas Bischler and
Patrick Schultz and
Mirko Bier and
Matthias Mann and
Herbert Tschochner Association of Yeast RNA Polymerase I
with a Nucleolar Substructure Active in
Rrna Synthesis and Processing . . . . . 575
Christine D. McCallum and
Hung Do and
Arthur E. Johnson and
Judith Frydman The Interaction of the Chaperonin
Tailless Complex Polypeptide 1 (Tcp1)
Ring Complex (Tric) with Ribosome--Bound
Nascent Chains Examined Using
Photo--Cross--Linking . . . . . . . . . 591
Marie Mancini and
Carolyn E. Machamer and
Sophie Roy and
Donald W. Nicholson and
Nancy A. Thornberry and
Livia A. Casciola-Rosen and
Antony Rosen Caspase-2 Is Localized at the Golgi
Complex and Cleaves Golgin-160 during
Apoptosis . . . . . . . . . . . . . . . 603
Shin-Jung Kang and
Suyue Wang and
Hideaki Hara and
Erin P. Peterson and
Shobu Namura and
Sepideh Amin-Hanjani and
Zhihong Huang and
Anu Srinivasan and
Kevin J. Tomaselli and
Nancy A. Thornberry and
Michael A. Moskowitz and
Junying Yuan Dual Role of Caspase-11 in Mediating
Activation of Caspase-1 and Caspase-3
under Pathological Conditions . . . . . 613
George Hausmann and
Lorraine A. O'Reilly and
Rosemary van Driel and
Jennifer G. Beaumont and
Andreas Strasser and
Jerry M. Adams and
David C. S. Huang Pro-Apoptotic Apoptosis
Protease--Activating Factor 1 (Apaf-1)
Has a Cytoplasmic Localization Distinct
from Bcl-2 or Bcl--X$_L$ . . . . . . . . 623
Kenneth A. Taylor and
Dianne W. Taylor and
Fred Schachat Isoforms of $ \alpha $-Actinin from
Cardiac, Smooth, and Skeletal Muscle
Form Polar Arrays of Actin Filaments . . 635
Ronald R. Dubreuil and
Ping Wang and
Steve Dahl and
John Lee and
Lawrence S. B. Goldstein Drosophila $ \beta $ Spectrin Functions
Independently of $ \alpha $ Spectrin to
Polarize the Na,k Atpase in Epithelial
Cells . . . . . . . . . . . . . . . . . 647
Bret B. Friday and
Valerie Horsley and
Grace K. Pavlath Calcineurin Activity Is Required for the
Initiation of Skeletal Muscle
Differentiation . . . . . . . . . . . . 657
Lisa Choy and
Jeremy Skillington and
Rik Derynck Roles of Autocrine TGF-$ \beta $
Receptor and Smad Signaling in Adipocyte
Differentiation . . . . . . . . . . . . 667
Cedric S. Wesley and
Lino Saez Analysis of Notch Lacking the Carboxyl
Terminus Identified in
\bionameDrosophila Embryos . . . . . . . 683
Lydia Bajno and
Xiao-Rong Peng and
Alan D. Schreiber and
Hsiao-Ping Moore and
William S. Trimble and
Sergio Grinstein Focal Exocytosis of Vamp3-Containing
Vesicles at Sites of Phagosome Formation 697
Petr Tvrdik and
Rolf Westerberg and
Sandra Silve and
Abolfazl Asadi and
Andreas Jakobsson and
Barbara Cannon and
Gerard Loison and
Anders Jacobsson Role of a New Mammalian Gene Family in
the Biosynthesis of Very Long Chain
Fatty Acids and Sphingolipids . . . . . 707
David W. Schmidtke and
Scott L. Diamond Direct Observation of Membrane Tethers
Formed during Neutrophil Attachment to
Platelets or P--Selectin under
Physiological Flow . . . . . . . . . . . 719
Hans Reinecke and
Glen H. MacDonald and
Stephen D. Hauschka and
Charles E. Murry Electromechanical Coupling between
Skeletal and Cardiac Muscle . . . . . . 731
Eduardo A. C. Almeida and
Du\vsko Ili\'c and
Qin Han and
Christof R. Hauck and
Fang Jin and
Hisaaki Kawakatsu and
David D. Schlaepfer and
Caroline H. Damsky Matrix Survival Signaling . . . . . . . 741
Urs Rutishauser Defining a Role and Mechanism for Igcam
Function in Vertebrate Axon Guidance . . 757
Jennifer S. Tirnauer and
Barbara E. Bierer Eb1 Proteins Regulate Microtubule
Dynamics, Cell Polarity, and Chromosome
Stability . . . . . . . . . . . . . . . 761
Isabelle Arnal and
Eric Karsenti and
Anthony A. Hyman Structural Transitions at Microtubule
Ends Correlate with Their Dynamic
Properties in \bionameXenopus Egg
Extracts . . . . . . . . . . . . . . . . 767
Gerben C. M. Zondag and
Eva E. Evers and
Jean P. ten Klooster and
Lennert Janssen and
Rob A. van der Kammen and
John G. Collard Oncogenic Ras Downregulates Rac
Activity, Which Leads to Increased Rho
Activity and Epithelial--Mesenchymal
Transition . . . . . . . . . . . . . . . 775
Xiang-ping He and
Feng Yang and
Zuo-ping Xie and
Bai Lu Intracellular Ca$^{2+}$ and Ca$^{2+}$
/Calmodulin--Dependent Kinase II Mediate
Acute Potentiation of Neurotransmitter
Release by Neurotrophin-3 . . . . . . . 783
Malcolm A. Leissring and
Yama Akbari and
Christopher M. Fanger and
Michael D. Cahalan and
Mark P. Mattson and
Frank M. LaFerla Capacitative Calcium Entry Deficits and
Elevated Luminal Calcium Content in
Mutant Presenilin-1 Knockin Mice . . . . 793
Yaron Daniely and
James A. Borowiec Formation of a Complex between Nucleolin
and Replication Protein a after Cell
Stress Prevents Initiation of DNA
Replication . . . . . . . . . . . . . . 799
Lita Freeman and
Luis Aragon-Alcaide and
Alexander Strunnikov The Condensin Complex Governs Chromosome
Condensation and Mitotic Transmission of
Rdna . . . . . . . . . . . . . . . . . . 811
Jacquelyn Gerhart and
Michael Baytion and
Steven DeLuca and
Robert Getts and
Christian Lopez and
Robert Niewenhuis and
Thor Nilsen and
Scott Olex and
Harold Weintraub and
Mindy George-Weinstein DNA Dendrimers Localize Myod mRNA in
Presomitic Tissues of the Chick Embryo 825
Michael E. Nemergut and
Ian G. Macara Nuclear Import of the Ran Exchange
Factor, Rcc1, Is Mediated by at Least
Two Distinct Mechanisms . . . . . . . . 835
Andreas Merdes and
Rebecca Heald and
Kumiko Samejima and
William C. Earnshaw and
Don W. Cleveland Formation of Spindle Poles by
Dynein/Dynactin-Dependent Transport of
Numa . . . . . . . . . . . . . . . . . . 851
Neil R. Adames and
John A. Cooper Microtubule Interactions with the Cell
Cortex Causing Nuclear Movements in
\bionameSaccharomyces cerevisiae . . . . 863
Holger Knaut and
Francisco Pelegri and
Kerstin Bohmann and
Heinz Schwarz and
Christiane Nüsslein-Volhard Zebrafish vasa RNA but Not Its Protein
Is a Component of the Germ Plasm and
Segregates Asymmetrically before
Germline Specification . . . . . . . . . 875
Sonia Martinez-Arca and
Philipp Alberts and
Ahmed Zahraoui and
Daniel Louvard and
Thierry Galli Role of Tetanus Neurotoxin Insensitive
Vesicle--Associated Membrane Protein
(Ti--Vamp) in Vesicular Transport
Mediating Neurite Outgrowth . . . . . . 889
Birte Sönnichsen and
Stefano De Renzis and
Erik Nielsen and
Jens Rietdorf and
Marino Zerial Distinct Membrane Domains on Endosomes
in the Recycling Pathway Visualized by
Multicolor Imaging of Rab4, Rab5, and
Rab11 . . . . . . . . . . . . . . . . . 901
Suraj Moorthy and
Lihsia Chen and
Vann Bennett \bionameCaenorhabditis elegans $ \beta
$-G Spectrin Is Dispensable for
Establishment of Epithelial Polarity,
but Essential for Muscular and Neuronal
Function . . . . . . . . . . . . . . . . 915
Marc Hammarlund and
Warren S. Davis and
Erik M. Jorgensen Mutations in $ \beta $-Spectrin Disrupt
Axon Outgrowth and Sarcomere Structure 931
Takayuki Kanazawa and
Sachiko Nakamura and
Michiko Momoi and
Toshiyuki Yamaji and
Hiromu Takematsu and
Hajime Yano and
Hisataka Sabe and
Akitsugu Yamamoto and
Toshisuke Kawasaki and
Yasunori Kozutsumi Inhibition of Cytokinesis by a Lipid
Metabolite, Psychosine . . . . . . . . . 943
Dora Fitzli and
Esther T. Stoeckli and
Stefan Kunz and
Kingsley Siribour and
Christoph Rader and
Beat Kunz and
Serguei V. Kozlov and
Andrea Buchstaller and
Robert P. Lane and
Daniel M. Suter and
William J. Dreyer and
Peter Sonderegger A Direct Interaction of Axonin-1 with
Ngcam--Related Cell Adhesion Molecule
(Nrcam) Results in Guidance, but Not
Growth of Commissural Axons . . . . . . 951
Lotus M. Th. Sterk and
Cecile A. W. Geuijen and
Lauran C. J. M. Oomen and
Jero Calafat and
Hans Janssen and
Arnoud Sonnenberg The Tetraspan Molecule Cd151, a Novel
Constituent of Hemidesmosomes,
Associates with the Integrin $ \alpha
$6$ \beta $4 and May Regulate the
Spatial Organization of Hemidesmosomes 969
Catherine J. Gress and
Olena Jacenko Growth Plate Compressions and Altered
Hematopoiesis in Collagen X Null Mice 983
Alan C. Rapraeger Syndecan-Regulated Receptor Signaling 995
Charles K. Kaufman and
Elaine Fuchs It's Got You Covered . . . . . . . . . . 999
Ye Jin and
Yanming Wang and
Jòrgen Johansen and
Kristen M. Johansen Jil-1, a Chromosomal Kinase Implicated
in Regulation of Chromatin Structure,
Associates with the Male Specific Lethal
(Msl) Dosage Compensation Complex . . . 1005
Girish V. Putcha and
Mohanish Deshmukh and
Eugene M. Johnson Inhibition of Apoptotic Signaling
Cascades Causes Loss of Trophic Factor
Dependence during Neuronal Maturation 1011
Lucio Gnessi and
Sabrina Basciani and
Stefania Mariani and
Mario Arizzi and
Giovanni Spera and
Chiayeng Wang and
Cecilia Bondjers and
Linda Karlsson and
Christer Betsholtz Leydig Cell Loss and Spermatogenic
Arrest in Platelet--Derived Growth
Factor (Pdgf)--a--Deficient Mice . . . . 1019
Nataliya Shulga and
Nima Mosammaparast and
Richard Wozniak and
David S. Goldfarb Yeast Nucleoporins Involved in Passive
Nuclear Envelope Permeability . . . . . 1027
Tadashi Suzuki and
Hangil Park and
Nancy M. Hollingsworth and
Rolf Sternglanz and
William J. Lennarz PNG1, a Yeast Gene Encoding a Highly
Conserved Peptide: N -Glycanase . . . . 1039
Paul R. Pryor and
Barbara M. Mullock and
Nicholas A. Bright and
Sally R. Gray and
J. Paul Luzio The Role of Intraorganellar Ca$^{2+}$ In
Late Endosome--Lysosome Heterotypic
Fusion and in the Reformation of
Lysosomes from Hybrid Organelles . . . . 1053
Thomas Weber and
Francesco Parlati and
James A. McNew and
Robert J. Johnston and
Benedikt Westermann and
Thomas H. Söllner and
James E. Rothman Snarepins Are Functionally Resistant to
Disruption by Nsf and $ \alpha $SNAP . . 1063
Toru Hirota and
Tetsuro Morisaki and
Yasuyuki Nishiyama and
Tomotoshi Marumoto and
Kenji Tada and
Toshihiro Hara and
Norio Masuko and
Masaki Inagaki and
Katsuyoshi Hatakeyama and
Hideyuki Saya Zyxin, a Regulator of Actin Filament
Assembly, Targets the Mitotic Apparatus
by Interacting with H-Warts/Lats1 Tumor
Suppressor . . . . . . . . . . . . . . . 1073
Arunashree Bhamidipati and
Sally A. Lewis and
Nicholas J. Cowan Adp Ribosylation Factor-like Protein 2
(Arl2) Regulates the Interaction of
Tubulin--Folding Cofactor D with Native
Tubulin . . . . . . . . . . . . . . . . 1087
Lu Xia and
Bing Hai and
Yan Gao and
Dylan Burnette and
Rupal Thazhath and
Jianming Duan and
Marie-Helene Bré and
Nicolette Levilliers and
Martin A. Gorovsky and
Jacek Gaertig Polyglycylation of Tubulin Is Essential
and Affects Cell Motility and Division
in \bionameTetrahymena thermophila . . . 1097
Julie Y. Pan and
William E. Fieles and
Anne M. White and
Mark M. Egerton and
David S. Silberstein Ges, a Human GTPase of the Rad/Gem/Kir
Family, Promotes Endothelial Cell
Sprouting and Cytoskeleton
Reorganization . . . . . . . . . . . . . 1107
Elena Dellambra and
Osvaldo Golisano and
Sergio Bondanza and
Emanuela Siviero and
Pedro Lacal and
Marta Molinari and
Stefania D'Atri and
Michele De Luca Downregulation of 14-3-3$ \sigma $
Prevents Clonal Evolution and Leads to
Immortalization of Primary Human
Keratinocytes . . . . . . . . . . . . . 1117
Bridget S. Wilson and
Janet R. Pfeiffer and
Janet M. Oliver Observing Fc$ \epsilon $ ri Signaling
from the Inside of the Mast Cell
Membrane . . . . . . . . . . . . . . . . 1131
Kousuke Iba and
Reidar Albrechtsen and
Brent Gilpin and
Camilla Fröhlich and
Frosty Loechel and
Anna Zolkiewska and
Kazuhiro Ishiguro and
Tetsuhito Kojima and
Wei Liu and
J. Kevin Langford and
Ralph D. Sanderson and
Cord Brakebusch and
Reinhard Fässler and
Ulla M. Wewer The Cysteine--Rich Domain of Human Adam
12 Supports Cell Adhesion through
Syndecans and Triggers Signaling Events
That Lead to $ \beta $1
Integrin--Dependent Cell Spreading . . . 1143
Katerina Akassoglou and
Keith W. Kombrinck and
Jay L. Degen and
Sidney Strickland Tissue Plasminogen Activator-Mediated
Fibrinolysis Protects against Axonal
Degeneration and Demyelination after
Sciatic Nerve Injury . . . . . . . . . . 1157
Vito Quaranta Cell Migration through Extracellular
Matrix . . . . . . . . . . . . . . . . . 1167
William B. Snyder and
Antonius Koller and
A. Jobu Choy and
Suresh Subramani The Peroxin Pex19p Interacts with
Multiple, Integral Membrane Proteins at
the Peroxisomal Membrane . . . . . . . . 1171
Robert D. Moir and
Timothy P. Spann and
Harald Herrmann and
Robert D. Goldman Disruption of Nuclear Lamin Organization
Blocks the Elongation Phase of DNA
Replication . . . . . . . . . . . . . . 1179
Masakiyo Sakaguchi and
Masahiro Miyazaki and
Yusuke Inoue and
Toshiya Tsuji and
Hirosuke Kouchi and
Toshio Tanaka and
Hidenori Yamada and
Masayoshi Namba Relationship between Contact Inhibition
and Intranuclear S100c of Normal Human
Fibroblasts . . . . . . . . . . . . . . 1193
Kurt De Vos and
Fedor Severin and
Franky Van Herreweghe and
Katia Vancompernolle and
Vera Goossens and
Anthony Hyman and
Johan Grooten Tumor Necrosis Factor Induces
Hyperphosphorylation of Kinesin Light
Chain and Inhibits Kinesin-Mediated
Transport of Mitochondria . . . . . . . 1207
Kazuo Emoto and
Masato Umeda An Essential Role for a Membrane Lipid
in Cytokinesis . . . . . . . . . . . . . 1215
Thorsten Hornemann and
Martin Stolz and
Theo Wallimann Isoenzyme-Specific Interaction of
Muscle--Type Creatine Kinase with the
Sarcomeric M--Line Is Mediated by Nh$_2$
-Terminal Lysine Charge--Clamps . . . . 1225
H. Llewelyn Roderick and
James D. Lechleiter and
Patricia Camacho Cytosolic Phosphorylation of Calnexin
Controls Intracellular Ca$^{2+}$
Oscillations via an Interaction with
Serca2b . . . . . . . . . . . . . . . . 1235
David Sancho and
Marta Nieto and
Manuel Llano and
José L. Rodríguez-Fernández and
Reyes Tejedor and
Shalom Avraham and
Carlos Cabañas and
Miguel López-Botet and
Francisco Sánchez-Madrid The Tyrosine Kinase Pyk-2/Raftk
Regulates Natural Killer (Nk) Cell
Cytotoxic Response, and Is Translocated
and Activated upon Specific Target Cell
Recognition and Killing . . . . . . . . 1249
Carlos Arregui and
Purnima Pathre and
Jack Lilien and
Janne Balsamo The Nonreceptor Tyrosine Kinase Fer
Mediates Cross--Talk between N--Cadherin
and $ \beta $1-Integrins . . . . . . . . 1263
Hedong Li and
Tin-Chung Leung and
Stanley Hoffman and
Janne Balsamo and
Jack Lilien Coordinate Regulation of Cadherin and
Integrin Function by the Chondroitin
Sulfate Proteoglycan Neurocan . . . . . 1275
Brent J. Miller and
Elisabeth Georges-Labouesse and
Paul Primakoff and
Diana G. Myles Normal Fertilization Occurs with Eggs
Lacking the Integrin $ \alpha $6$ \beta
$1 and Is Cd9-Dependent . . . . . . . . 1289
Alka Mansukhani and
Paola Bellosta and
Malika Sahni and
Claudio Basilico Signaling by Fibroblast Growth Factors
(Fgf) and Fibroblast Growth Factor
Receptor 2 (Fgfr2)--Activating Mutations
Blocks Mineralization and Induces
Apoptosis in Osteoblasts . . . . . . . . 1297
Kevin Hotary and
Edward Allen and
Antonello Punturieri and
Ikuo Yana and
Stephen J. Weiss Regulation of Cell Invasion and
Morphogenesis in a Three--Dimensional
Type I Collagen Matrix by Membrane--Type
Matrix Metalloproteinases 1, 2, and 3 1309
Feng Wei and
Zao C. Xu and
Zhican Qu and
Jeffrey Milbrandt and
Min Zhuo Role of Egr1 in Hippocampal Synaptic
Enhancement Induced by Tetanic
Stimulation and Amputation . . . . . . . 1325
Sharif U. Ahmed and
Enrique Rojo and
Valentina Kovaleva and
Sridhar Venkataraman and
James E. Dombrowski and
Ken Matsuoka and
Natasha V. Raikhel The Plant Vacuolar Sorting Receptor
Atelp Is Involved in Transport of Nh$_2$
-Terminal Propeptide--Containing
Vacuolar Proteins in Arabidopsis
thaliana . . . . . . . . . . . . . . . . 1335
Sarah T. South and
Katherine A. Sacksteder and
Xiaoling Li and
Yifei Liu and
Stephen J. Gould Inhibitors of COPI and COPII Do Not
Block PEX3-Mediated Peroxisome Synthesis 1345
Adam D. Rudner and
Kevin G. Hardwick and
Andrew W. Murray Cdc28 Activates Exit from Mitosis in
Budding Yeast . . . . . . . . . . . . . 1361
Adam D. Rudner and
Andrew W. Murray Phosphorylation by Cdc28 Activates the
Cdc20-Dependent Activity of the
Anaphase--Promoting Complex . . . . . . 1377
Verena Jantsch-Plunger and
Pierre Gönczy and
Alper Romano and
Heinke Schnabel and
Danielle Hamill and
Ralf Schnabel and
Anthony A. Hyman and
Michael Glotzer Cyk-4 . . . . . . . . . . . . . . . . . 1391
Torsten Wittmann and
Matthias Wilm and
Eric Karsenti and
Isabelle Vernos Tpx2, a Novel \bionameXenopus Map
Involved in Spindle Pole Organization 1405
Ute Schaeper and
Niels H. Gehring and
Klaus P. Fuchs and
Martin Sachs and
Bettina Kempkes and
Walter Birchmeier Coupling of Gab1 to C--Met, Grb2, and
Shp2 Mediates Biological Responses . . . 1419
Monica A. Torres and
W. James Nelson Colocalization and Redistribution of
Dishevelled and Actin during
WNT--Induced Mesenchymal Morphogenesis 1433
Dunja Frey and
Thorsten Laux and
Lan Xu and
Corinna Schneider and
Pico Caroni Shared and Unique Roles of Cap23 and
Gap43 in Actin Regulation, Neurite
Outgrowth, and Anatomical Plasticity . . 1443
Thorsten Laux and
Kiyoko Fukami and
Marcus Thelen and
Tamara Golub and
Dunja Frey and
Pico Caroni Gap43, Marcks, and Cap23 Modulate
Pi(4,5)p$_2$ at Plasmalemmal Rafts, and
Regulate Cell Cortex Actin Dynamics
through a Common Mechanism . . . . . . . 1455
Pamela J. Plant and
Frank Lafont and
Sandra Lecat and
Paul Verkade and
Kai Simons and
Daniela Rotin Apical Membrane Targeting of Nedd4 Is
Mediated by an Association of Its C2
Domain with Annexin Xiiib . . . . . . . 1473
Steve Silletti and
Fang Mei and
Dean Sheppard and
Anthony M. P. Montgomery Plasmin-Sensitive Dibasic Sequences in
the Third Fibronectin-like Domain of
L1--Cell Adhesion Molecule (Cam)
Facilitate Homomultimerization and
Concomitant Integrin Recruitment . . . . 1485
Paul D. Lampe and
Erica M. TenBroek and
Janis M. Burt and
Wendy E. Kurata and
Ross G. Johnson and
Alan F. Lau Phosphorylation of Connexin43 on
Serine368 by Protein Kinase C Regulates
Gap Junctional Communication . . . . . . 1503
Nathalie Rouach and
Jacques Glowinski and
Christian Giaume Activity-Dependent Neuronal Control of
Gap--Junctional Communication in
Astrocytes . . . . . . . . . . . . . . . 1513
Lindsay S. Shopland and
Jeanne B. Lawrence Seeking Common Ground in Nuclear
Complexity . . . . . . . . . . . . . . . ??
Douglas R. Green Apoptosis and Sphingomyelin Hydrolysis ??
Michael D. Schaller Unc112 . . . . . . . . . . . . . . . . . ??
Ronald D. Vale Aaa Proteins . . . . . . . . . . . . . . ??
Jennifer K. Yucel and
Janet D. Marszalek and
J. Richard McIntosh and
Lawrence S. B. Goldstein and
Don W. Cleveland and
Alastair Valentine Philp CENP-meta, an Essential Kinetochore
Kinesin Required for the Maintenance of
Metaphase Chromosome Alignment in
\bionameDrosophila . . . . . . . . . . . ??
Charlotte A. Spencer and
Michael J. Kruhlak and
Heather L. Jenkins and
Xuejun Sun and
David P. Bazett-Jones Mitotic Transcription Repression in Vivo
in the Absence of Nucleosomal Chromatin
Condensation . . . . . . . . . . . . . . 13
Masahiro Iwamoto and
Yoshinobu Higuchi and
Eiki Koyama and
Motomi Enomoto-Iwamoto and
Kojiro Kurisu and
Helena Yeh and
William R. Abrams and
Joel Rosenbloom and
Maurizio Pacifici Transcription Factor Erg Variants and
Functional Diversification of
Chondrocytes during Limb Long Bone
Development . . . . . . . . . . . . . . 27
Michael J. Kruhlak and
Melody A. Lever and
Wolfgang Fischle and
Eric Verdin and
David P. Bazett-Jones and
Michael J. Hendzel Reduced Mobility of the Alternate
Splicing Factor (Asf) through the
Nucleoplasm and Steady State Speckle
Compartments . . . . . . . . . . . . . . 41
David Raden and
Weiqun Song and
Reid Gilmore Role of the Cytoplasmic Segments of
Sec61$ \alpha $ in the Ribosome--Binding
and Translocation--Promoting Activities
of the Sec61 Complex . . . . . . . . . . 53
C. Randell Brown and
Jameson A. McCann and
Hui-Ling Chiang The Heat Shock Protein Ssa2p Is Required
for Import of
Fructose-1,6-Bisphosphatase into Vid
Vesicles . . . . . . . . . . . . . . . . 65
Davis T. W. Ng and
Eric D. Spear and
Peter Walter The Unfolded Protein Response Regulates
Multiple Aspects of Secretory and
Membrane Protein Biogenesis and
Endoplasmic Reticulum Quality Control 77
Christelle Alory and
William E. Balch Molecular Basis for Rab Prenylation . . 89
James A. McNew and
Thomas Weber and
Francesco Parlati and
Robert J. Johnston and
Thomas J. Melia and
Thomas H. Söllner and
James E. Rothman Close Is Not Enough . . . . . . . . . . 105
Harald Hölzl and
Barbara Kapelari and
Josef Kellermann and
Erika Seemüller and
Máté Sümegi and
Andor Udvardy and
Ohad Medalia and
Joseph Sperling and
Shirley A. Müller and
Andreas Engel and
Wolfgang Baumeister The Regulatory Complex of
\bionameDrosophila melanogaster 26s
Proteasomes . . . . . . . . . . . . . . 119
Mohanish Deshmukh and
Keisuke Kuida and
Eugene M. Johnson Caspase Inhibition Extends the
Commitment to Neuronal Death Beyond
Cytochrome c Release to the Point of
Mitochondrial Depolarization . . . . . . 131
Kenneth N. Fish and
Sandra L. Schmid and
Hanna Damke Evidence That Dynamin-2 Functions as a
Signal--Transducing Gtpase . . . . . . . 145
Annemiek D. Tepper and
Paula Ruurs and
Therese Wiedmer and
Peter J. Sims and
Jannie Borst and
Wim J. van Blitterswijk Sphingomyelin Hydrolysis to Ceramide
during the Execution Phase of Apoptosis
Results from Phospholipid Scrambling and
Alters Cell--Surface Morphology . . . . 155
Steven Ackerley and
Andrew J. Grierson and
Janet Brownlees and
Paul Thornhill and
Brian H. Anderton and
P. Nigel Leigh and
Christopher E. Shaw and
Christopher C. J. Miller Glutamate Slows Axonal Transport of
Neurofilaments in Transfected Neurons 165
Lilly Y. W. Bourguignon and
Hongbo Zhu and
Lijun Shao and
Yue Wei Chen Ankyrin--Tiam1 Interaction Promotes Rac1
Signaling and Metastatic Breast Tumor
Cell Invasion and Migration . . . . . . 177
Alexis Gautreau and
Daniel Louvard and
Monique Arpin Morphogenic Effects of Ezrin Require a
Phosphorylation--Induced Transition from
Oligomers to Monomers at the Plasma
Membrane . . . . . . . . . . . . . . . . 193
Christi Weston and
Barry Yee and
Eldad Hod and
Joav Prives Agrin-Induced Acetylcholine Receptor
Clustering Is Mediated by the Small
Guanosine Triphosphatases Rac and Cdc42 205
Orit Aharonovitz and
Hans C. Zaun and
Tamas Balla and
John D. York and
John Orlowski and
Sergio Grinstein Intracellular Ph Regulation by Na$^+$
/H$^+$ Exchange Requires
Phosphatidylinositol 4,5-Bisphosphate 213
Toshihiko Toyofuku and
Zhang Hong and
Tsunehiko Kuzuya and
Michihiko Tada and
Masatsugu Hori WNT\slash Frizzled-2 Signaling Induces
Aggregation and Adhesion among Cardiac
Myocytes by Increased Cadherin-$ \beta
$-Catenin Complex . . . . . . . . . . . 225
Li Tian and
Henrietta Nyman and
Patrick Kilgannon and
Yoshihiro Yoshihara and
Kensaku Mori and
Leif C. Andersson and
Sami Kaukinen and
Heikki Rauvala and
W. Michael Gallatin and
Carl G. Gahmberg Intercellular Adhesion Molecule-5
Induces Dendritic Outgrowth by
Homophilic Adhesion . . . . . . . . . . 243
Teresa M. Rogalski and
Gregory P. Mullen and
Mary M. Gilbert and
Benjamin D. Williams and
Donald G. Moerman The UNC-112 Gene in
\bionameCaenorhabditis elegans Encodes a
Novel Component of Cell--Matrix Adhesion
Structures Required for Integrin
Localization in the Muscle Cell Membrane 253
Anna von Mikecz and
Suisheng Zhang and
Marc Montminy and
Eng M. Tan and
Peter Hemmerich Creb-Binding Protein (Cbp/P300) and RNA
Polymerase II Colocalize in
Transcriptionally Active Domains in the
Nucleus . . . . . . . . . . . . . . . . 265
Laurent Créancier and
Dominique Morello and
Pascale Mercier and
Anne-Catherine Prats Fibroblast Growth Factor 2 Internal
Ribosome Entry Site (Ires) Activity Ex
Vivo and in Transgenic Mice Reveals a
Stringent Tissue--Specific Regulation 275
Ira Mellman Genomics Comes to Cell Biology . . . . . 1
Mark E. Fortini and
Marian P. Skupski and
Mark S. Boguski and
Iswar K. Hariharan A Survey of Human Disease Gene
Counterparts in the \bionameDrosophila
Genome . . . . . . . . . . . . . . . . . ??
Jeff J. Sekelsky and
Michael H. Brodsky and
Kenneth C. Burtis DNA Repair in \bionameDrosophila . . . . ??
Stephen M. Mount and
Helen K. Salz Pre-Messenger RNA Processing Factors in
the \bionameDrosophila Genome . . . . . ??
Norikazu Aoyagi and
David A. Wassarman Genes Encoding \bionameDrosophila
melanogaster RNA Polymerase II General
Transcription Factors . . . . . . . . . ??
Paul Lasko The \bionameDrosophila melanogaster
Genome . . . . . . . . . . . . . . . . . ??
Deborah K. Morrison and
Monica S. Murakami and
Vaughn Cleghon Protein Kinases and Phosphatases in the
\bionameDrosophila Genome . . . . . . . ??
Lawrence S. B. Goldstein and
Shermali Gunawardena Flying through the \bionameDrosophila
Cytoskeletal Genome . . . . . . . . . . ??
Stephanie Y. Vernooy and
Jeffrey Copeland and
Nazli Ghaboosi and
Erik E. Griffin and
Soon Ji Yoo and
Bruce A. Hay Cell Death Regulation in
\bionameDrosophila . . . . . . . . . . . ??
J. Troy Littleton A Genomic Analysis of Membrane
Trafficking and Neurotransmitter Release
in \bionameDrosophila . . . . . . . . . ??
Thomas Brody and
Anibal Cravchik Drosophila melanogaster G
Protein--Coupled Receptors . . . . . . . ??
Richard O. Hynes and
Qi Zhao The Evolution of Cell Adhesion . . . . . ??
Satoshi Tashiro and
Joachim Walter and
Akira Shinohara and
Nanao Kamada and
Thomas Cremer Rad51 Accumulation at Sites of DNA
Damage and in Postreplicative Chromatin 283
S. Homburg and
L. Visochek and
N. Moran and
F. Dantzer and
E. Priel and
E. Asculai and
D. Schwartz and
V. Rotter and
N. Dekel and
M. Cohen-Armon A Fast Signal--Induced Activation of
Poly(Adp--Ribose) Polymerase . . . . . . 293
Tim McGarvey and
Emanuel Rosonina and
Susan McCracken and
Qiyu Li and
Ramy Arnaout and
Edwin Mientjes and
Jeffrey A. Nickerson and
Don Awrey and
Jack Greenblatt and
Gerard Grosveld and
Benjamin J. Blencowe The Acute Myeloid Leukemia--Associated
Protein, Dek, Forms a
Splicing--Dependent Interaction with
Exon--Product Complexes . . . . . . . . 309
Delphine Lechardeur and
Luke Drzymala and
Manu Sharma and
Danuta Zylka and
Robert Kinach and
Joanna Pacia and
Christopher Hicks and
Nawaid Usmani and
Johanna M. Rommens and
Gergely L. Lukacs Determinants of the Nuclear Localization
of the Heterodimeric DNA Fragmentation
Factor (Icad/Cad) . . . . . . . . . . . 321
Saadi Ghatan and
Stephen Larner and
Yoshito Kinoshita and
Michal Hetman and
Leena Patel and
Zhengui Xia and
Richard J. Youle and
Richard S. Morrison p38 Map Kinase Mediates Bax
Translocation in Nitric Oxide--Induced
Apoptosis in Neurons . . . . . . . . . . 335
Norman R. Watts and
Dan L. Sackett and
Rita D. Ward and
Mill W. Miller and
Paul T. Wingfield and
Stephen S. Stahl and
Alasdair C. Steven HIV-1 Rev Depolymerizes Microtubules to
Form Stable Bilayered Rings . . . . . . 349
Clare Waterman-Storer and
Devin Y. Duey and
Kari L. Weber and
John Keech and
Richard E. Cheney and
E. D. Salmon and
William M. Bement Microtubules Remodel Actomyosin Networks
in \bionameXenopus Egg Extracts via Two
Mechanisms of F--Actin Transport . . . . 361
Gian-Carlo Ochoa and
Vladimir I. Slepnev and
Lynn Neff and
Niels Ringstad and
Kohji Takei and
Laurie Daniell and
Warren Kim and
Hong Cao and
Mark McNiven and
Roland Baron and
Pietro De Camilli A Functional Link between Dynamin and
the Actin Cytoskeleton at Podosomes . . 377
Christine Hunter and
Eric Wieschaus Regulated Expression of nullo Is
Required for the Formation of Distinct
Apical and Basal Adherens Junctions in
the \bionameDrosophila Blastoderm . . . 391
Bruce D. Trapp and
Grahame J. Kidd Axo-Glial Septate Junctions . . . . . . 1
Ying-Hao Chou and
Robert D. Goldman Intermediate Filaments on the Move . . . ??
Ana Losada and
Tomoki Yokochi and
Ryuji Kobayashi and
Tatsuya Hirano Identification and Characterization of
Sa/Scc3p Subunits in the \bionameXenopus
and Human Cohesin Complexes . . . . . . 405
Carol Johnson and
Dragan Primorac and
Monique McKinstry and
John McNeil and
David Rowe and
Jeanne Bentley Lawrence Tracking Col1a1 RNA in Osteogenesis
Imperfecta . . . . . . . . . . . . . . . 417
Miroslav Dundr and
Tom Misteli and
Mark O. J. Olson The Dynamics of Postmitotic Reassembly
of the Nucleolus . . . . . . . . . . . . 433
Rajendra K. Agrawal and
Christian M. T. Spahn and
Pawel Penczek and
Robert A. Grassucci and
Knud H. Nierhaus and
Joachim Frank Visualization of Trna Movements on the
\bionameEscherichia coli 70s Ribosome
during the Elongation Cycle . . . . . . 447
William A. Prinz and
Lara Grzyb and
Marten Veenhuis and
Jason A. Kahana and
Pamela A. Silver and
Tom A. Rapoport Mutants Affecting the Structure of the
Cortical Endoplasmic Reticulum in
\bionameSaccharomyces cerevisiae . . . . 461
A. Barbara Dirac-Svejstrup and
James Shorter and
M. Gerard Waters and
Graham Warren Phosphorylation of the
Vesicle--Tethering Protein P115 by a
Casein Kinase II-like Enzyme Is Required
for Golgi Reassembly from Isolated
Mitotic Fragments . . . . . . . . . . . 475
Carlo W. T. van Roermund and
Henk F. Tabak and
Marlene van den Berg and
Ronald J. A. Wanders and
Ewald H. Hettema Pex11p Plays a Primary Role in
Medium--Chain Fatty Acid Oxidation, a
Process That Affects Peroxisome Number
and Size in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 489
Gregory C. Rogers and
Kitty K. Chui and
Edwin W. Lee and
Karen P. Wedaman and
David J. Sharp and
Gina Holland and
Robert L. Morris and
Jonathan M. Scholey A Kinesin--Related Protein, Krp$_{180}$,
Positions Prometaphase Spindle Poles
during Early Sea Urchin Embryonic Cell
Division . . . . . . . . . . . . . . . . 499
Natalie L. Catlett and
Jason E. Duex and
Fusheng Tang and
Lois S. Weisman Two Distinct Regions in a Yeast
Myosin--V Tail Domain Are Required for
the Movement of Different Cargoes . . . 513
Justin Skoble and
Daniel A. Portnoy and
Matthew D. Welch Three Regions within ActA Promote Arp2/3
Complex-Mediated Actin Nucleation and
\bionameListeria monocytogenes Motility 527
Karen Oegema and
Matthew S. Savoian and
Timothy J. Mitchison and
Christine M. Field Functional Analysis of a Human Homologue
of the \bionameDrosophila Actin Binding
Protein Anillin Suggests a Role in
Cytokinesis . . . . . . . . . . . . . . 539
K. Ojima and
Z. X. Lin and
M.-L. Bang and
S. Holtzer and
R. Matsuda and
S. Labeit and
H. L. Sweeney and
H. Holtzer Distinct Families of Z--Line Targeting
Modules in the Cooh--Terminal Region of
Nebulin . . . . . . . . . . . . . . . . 553
Nicole K. Noren and
Betty P. Liu and
Keith Burridge and
Bertolt Kreft P120 Catenin Regulates the Actin
Cytoskeleton via Rho Family Gtpases . . 567
Ingeborg Berg and
Barry V. L. Potter and
Georg W. Mayr and
Andreas H. Guse Nicotinic Acid Adenine Dinucleotide
Phosphate (Naadp$^+$) Is an Essential
Regulator of T-Lymphocyte
Ca$^{2+}$-Signaling . . . . . . . . . . 581
Todd W. Harris and
Erika Hartwieg and
H. Robert Horvitz and
Erik M. Jorgensen Mutations in Synaptojanin Disrupt
Synaptic Vesicle Recycling . . . . . . . 589
Yves Gaudin Rabies Virus--Induced Membrane Fusion
Pathway . . . . . . . . . . . . . . . . 601
Robert A. Screaton and
Luisa DeMarte and
Petr Dráber and
Clifford P. Stanners The Specificity for the Differentiation
Blocking Activity of Carcinoembryonic
Antigen Resides in Its
Glycophosphatidyl--Inositol Anchor . . . 613
Jeffrey A. Greenwood and
Anne B. Theibert and
Glenn D. Prestwich and
Joanne E. Murphy-Ullrich Restructuring of Focal Adhesion Plaques
by Pi 3-Kinase . . . . . . . . . . . . . 627
Mana M. Parast and
Carol A. Otey Characterization of Palladin, a Novel
Protein Localized to Stress Fibers and
Cell Adhesions . . . . . . . . . . . . . 643
Steven Tait and
Frank Gunn-Moore and
J. Martin Collinson and
Jeffery Huang and
Catherine Lubetzki and
Liliana Pedraza and
Diane L. Sherman and
David R. Colman and
Peter J. Brophy An Oligodendrocyte Cell Adhesion
Molecule at the Site of Assembly of the
Paranodal Axo--Glial Junction . . . . . 657
Barbara Gayraud and
Douglas R. Keene and
Lynn Y. Sakai and
Francesco Ramirez New Insights into the Assembly of
Extracellular Microfibrils from the
Analysis of the Fibrillin 1 Mutation in
the Tight skin Mouse . . . . . . . . . . 667
Vladimir P. Efimov and
N. Ronald Morris The Lis1-Related Nudf Protein of
\bionameAspergillus nidulans Interacts
with the Coiled-Coil Domain of the
Nude/Ro11 Protein . . . . . . . . . . . 681
Hans-Georg Koch and
Matthias Müller Dissecting the Translocase and Integrase
Functions of the \bionameEscherichia
coli Secyeg Translocon . . . . . . . . . 689
Anne Ridley Rho Gtpases . . . . . . . . . . . . . . 0
Katja Sträßer and
Jochen Baßler and
Ed Hurt Binding of the Mex67p/Mtr2p Heterodimer
to Fxfg, Glfg, and Fg Repeat
Nucleoporins Is Essential for Nuclear
mRNA Export . . . . . . . . . . . . . . 695
Chi Y. Yun and
Xiang-Dong Fu Conserved Sr Protein Kinase Functions in
Nuclear Import and Its Action Is
Counteracted by Arginine Methylation in
\bionameSaccharomyces cerevisiae . . . . 707
Yuichiro Kida and
Masao Sakaguchi and
Mitsunori Fukuda and
Katsuhiko Mikoshiba and
Katsuyoshi Mihara Membrane Topogenesis of a Type I
Signal--Anchor Protein, Mouse
Synaptotagmin Ii, on the Endoplasmic
Reticulum . . . . . . . . . . . . . . . 719
Kimitoshi Nakamura and
Ella Bossy-Wetzel and
Kimberly Burns and
Marc P. Fadel and
Mira Lozyk and
Ing Swie Goping and
Michal Opas and
R. Chris Bleackley and
Douglas R. Green and
Marek Michalak Changes in Endoplasmic Reticulum Luminal
Environment Affect Cell Sensitivity to
Apoptosis . . . . . . . . . . . . . . . 731
Graham C. Fletcher and
Luzheng Xue and
Shareta K. Passingham and
Aviva M. Tolkovsky Death Commitment Point Is Advanced by
Axotomy in Sympathetic Neurons . . . . . 741
Liwen Jiang and
Thomas E. Phillips and
Sally W. Rogers and
John C. Rogers Biogenesis of the Protein Storage
Vacuole Crystalloid . . . . . . . . . . 755
Jeffrey A. Spencer and
Susan Eliazer and
Robert L. Ilaria and
James A. Richardson and
Eric N. Olson Regulation of Microtubule Dynamics and
Myogenic Differentiation by Murf, a
Striated Muscle Ring--Finger Protein . . 771
M. Glogauer and
J. Hartwig and
T. Stossel Two Pathways through Cdc42 Couple the N
-Formyl Receptor to Actin Nucleation in
Permeabilized Human Neutrophils . . . . 785
Go Totsukawa and
Yoshihiko Yamakita and
Shigeko Yamashiro and
David J. Hartshorne and
Yasuharu Sasaki and
Fumio Matsumura Distinct Roles of Rock (Rho--Kinase) and
Mlck in Spatial Regulation of Mlc
Phosphorylation for Assembly of Stress
Fibers and Focal Adhesions in 3t3
Fibroblasts . . . . . . . . . . . . . . 797
Josephine Clare Adams and
Martin Alexander Schwartz Stimulation of Fascin Spikes by
Thrombospondin-1 Is Mediated by the
Gtpases Rac and Cdc42 . . . . . . . . . 807
Douglas N. Robinson and
James A. Spudich Dynacortin, a Genetic Link between
Equatorial Contractility and Global
Shape Control Discovered by Library
Complementation of a
\bionameDictyostelium discoideum
Cytokinesis Mutant . . . . . . . . . . . 823
Amanda J. Cochilla and
Joseph K. Angleson and
William J. Betz Differential Regulation of
Granule--to--Granule and
Granule--to--Plasma Membrane Fusion
during Secretion from Rat Pituitary
Lactotrophs . . . . . . . . . . . . . . 839
Thomas Lecuit and
Eric Wieschaus Polarized Insertion of New Membrane from
a Cytoplasmic Reservoir during Cleavage
of the \bionameDrosophila Embryo . . . . 849
Yao Huang and
Ji Li and
Yongjun Zhang and
Chuanyue Wu The Roles of Integrin--Linked Kinase in
the Regulation of Myogenic
Differentiation . . . . . . . . . . . . 861
Ayako Yamamoto and
Yoshihiro Hashimoto and
Kenjiro Kohri and
Etsuro Ogata and
Shige-aki Kato and
Kyoji Ikeda and
Makoto Nakanishi Cyclin E as a Coactivator of the
Androgen Receptor . . . . . . . . . . . 873
Vladimir I. Titorenko and
Richard A. Rachubinski Peroxisomal Membrane Fusion Requires Two
Aaa Family Atpases, Pex1p and Pex6p . . 881
Toshiyuki Nakagawa and
Junying Yuan Cross-Talk between Two Cysteine Protease
Families . . . . . . . . . . . . . . . . 887
Amy K. Wolven and
Lisa D. Belmont and
Nicole M. Mahoney and
Steven C. Almo and
David G. Drubin In Vivo Importance of Actin Nucleotide
Exchange Catalyzed by Profilin . . . . . 895
Stefano Confalonieri and
Anna Elisabetta Salcini and
Claudia Puri and
Carlo Tacchetti and
Pier Paolo Di Fiore Tyrosine Phosphorylation of Eps15 Is
Required for Ligand--Regulated, but Not
Constitutive, Endocytosis . . . . . . . 905
Melissa B. Wenk and
Kim S. Midwood and
Jean E. Schwarzbauer Tenascin-C Suppresses Rho Activation . . 913
Pauline Wong and
Emma Colucci-Guyon and
Kenzo Takahashi and
Changhong Gu and
Charles Babinet and
Pierre A. Coulombe Introducing a Null Mutation in the Mouse
K6$ \alpha $ and K6$ \beta $ Genes
Reveals Their Essential Structural Role
in the Oral Mucosa . . . . . . . . . . . 921
Yosef Landesman and
Daniel A. Goodenough and
David L. Paul Gap Junctional Communication in the
Early \bionameXenopus Embryo . . . . . . 929
Britta Qualmann and
Michael M. Kessels and
Regis B. Kelly Molecular Links between Endocytosis and
the Actin Cytoskeleton . . . . . . . . . 0
Jonathan D. Wood and
Frederick C. Nucifora and
Kui Duan and
Chuanyi Zhang and
Jianxiang Wang and
Yujin Kim and
Gabriele Schilling and
Nicoletta Sacchi and
Johnson M. Liu and
Christopher A. Ross Atrophin-1, the Dentato--Rubral and
Pallido--Luysian Atrophy Gene Product,
Interacts with Eto/Mtg8 in the Nuclear
Matrix and Represses Transcription . . . 939
Oliver Nayler and
Annette M. Hartmann and
Stefan Stamm The ER Repeat Protein Yt521-B Localizes
to a Novel Subnuclear Compartment . . . 949
Daniel Pérez-Mongiovi and
Clare Beckhelling and
Patrick Chang and
Christopher C. Ford and
Evelyn Houliston Nuclei and Microtubule Asters Stimulate
Maturation/M Phase Promoting Factor
(Mpf) Activation in \bionameXenopus Eggs
and Egg Cytoplasmic Extracts . . . . . . 963
Tarun M. Kapoor and
Thomas U. Mayer and
Margaret L. Coughlin and
Timothy J. Mitchison Probing Spindle Assembly Mechanisms with
Monastrol, a Small Molecule Inhibitor of
the Mitotic Kinesin, Eg5 . . . . . . . . 975
Yosuke Takei and
Junlin Teng and
Akihiro Harada and
Nobutaka Hirokawa Defects in Axonal Elongation and
Neuronal Migration in Mice with
Disrupted tau and map1b Genes . . . . . 989
Changsong Yang and
Minzhou Huang and
John DeBiasio and
Martin Pring and
Michael Joyce and
Hiroaki Miki and
Tadaomi Takenawa and
Sally H. Zigmond Profilin Enhances Cdc42-Induced
Nucleation of Actin Polymerization . . . 1001
Eva M. Neuhaus and
Thierry Soldati A Myosin I Is Involved in Membrane
Recycling from Early Endosomes . . . . . 1013
Oliver von Ahsen and
Christian Renken and
Guy Perkins and
Ruth M. Kluck and
Ella Bossy-Wetzel and
Donald D. Newmeyer Preservation of Mitochondrial Structure
and Function after Bid- or Bax-Mediated
Cytochrome c Release . . . . . . . . . . 1027
Josée N. Lavoie and
Claudia Champagne and
Marie-Claude Gingras and
Amélie Robert Adenovirus E4 Open Reading Frame
4--Induced Apoptosis Involves
Dysregulation of Src Family Kinases . . 1037
Richard D. Minshall and
Chinnaswamy Tiruppathi and
Stephen M. Vogel and
Walter D. Niles and
Annette Gilchrist and
Heidi E. Hamm and
Asrar B. Malik Endothelial Cell--Surface Gp60 Activates
Vesicle Formation and Trafficking via
G$_i$ -Coupled Src Kinase Signaling
Pathway . . . . . . . . . . . . . . . . 1057
Larry S. Sherman and
Tilat A. Rizvi and
Saikumar Karyala and
Nancy Ratner Cd44 Enhances Neuregulin Signaling by
Schwann Cells . . . . . . . . . . . . . 1071
Joon Yung Lee and
Zhuqing Qu-Petersen and
Baohong Cao and
Shigemi Kimura and
Ron Jankowski and
James Cummins and
Arvydas Usas and
Charley Gates and
Paul Robbins and
Anton Wernig and
Johnny Huard Clonal Isolation of Muscle--Derived
Cells Capable of Enhancing Muscle
Regeneration and Bone Healing . . . . . 1085
Dong Min Shin and
Xiao-Song Zhao and
Weizhong Zeng and
Marina Mozhayeva and
Shmuel Muallem The Mammalian Sec6/8 Complex Interacts
with Ca$^{2+}$ Signaling Complexes and
Regulates Their Activity . . . . . . . . 1101
Eduard B. Babiychuk and
Annette Draeger Annexins in Cell Membrane Dynamics . . . 1113
Radhika C. Desai and
Bimal Vyas and
Cynthia A. Earles and
J. Troy Littleton and
Judith A. Kowalchyck and
Thomas F. J. Martin and
E. R. Chapman The C2b Domain of Synaptotagmin Is a
Ca$^{2+}$ --Sensing Module Essential for
Exocytosis . . . . . . . . . . . . . . . 1125
Sanja Sever and
Hanna Damke and
Sandra L. Schmid Dynamin: GTP Controls the Formation of
Constricted Coated Pits, the Rate
Limiting Step in Clathrin-Mediated
Endocytosis . . . . . . . . . . . . . . 1137
Srikala Raghavan and
Christoph Bauer and
Gina Mundschau and
Qingqin Li and
Elaine Fuchs Conditional Ablation of $ \beta $1
Integrin in Skin . . . . . . . . . . . . 1149
Kouichi Tachibana and
Hiroyuki Nakanishi and
Kenji Mandai and
Kumi Ozaki and
Wataru Ikeda and
Yasunori Yamamoto and
Akira Nagafuchi and
Shoichiro Tsukita and
Yoshimi Takai Two Cell Adhesion Molecules, Nectin and
Cadherin, Interact through Their
Cytoplasmic Domain--Associated Proteins 1161
Atsuko Ishizuya-Oka and
Qing Li and
Tosikazu Amano and
Sashko Damjanovski and
Shuichi Ueda and
Yun-Bo Shi Requirement for Matrix Metalloproteinase
Stromelysin-3 in Cell Migration and
Apoptosis during Tissue Remodeling in
\bionameXenopus laevis . . . . . . . . . 1177
Theodore P. Rasmussen and
Mary-Ann Mastrangelo and
Amir Eden and
John R. Pehrson and
Rudolf Jaenisch Dynamic Relocalization of Histone
Macroh2a1 from Centrosomes to Inactive X
Chromosomes during X Inactivation . . . 1189
María Victoria González and
Benilde Jiménez and
María T. Berciano and
José Manuel González-Sancho and
Carme Caelles and
Miguel Lafarga and
Alberto Muñoz Glucocorticoids Antagonize Ap-1 by
Inhibiting the
Activation/Phosphorylation of Jnk
without Affecting Its Subcellular
Distribution . . . . . . . . . . . . . . 1199
Inna N. Rybakova and
Jitandrakumar R. Patel and
James M. Ervasti The Dystrophin Complex Forms a
Mechanically Strong Link between the
Sarcolemma and Costameric Actin . . . . 1209
Patricia Murray and
David Edgar Regulation of Programmed Cell Death by
Basement Membranes in Embryonic
Development . . . . . . . . . . . . . . 1215
Sally H. Zigmond How Wasp Regulates Actin Polymerization 0
Louise P. Cramer Myosin VI . . . . . . . . . . . . . . . ??
Leocadia V. Paliulis and
R. Bruce Nicklas The Reduction of Chromosome Number in
Meiosis Is Determined by Properties
Built into the Chromosomes . . . . . . . 1223
B. J. Howell and
D. B. Hoffman and
G. Fang and
A. W. Murray and
E. D. Salmon Visualization of Mad2 Dynamics at
Kinetochores, along Spindle Fibers, and
at Spindle Poles in Living Cells . . . . 1233
Rikke L. Steen and
Sandra B. Martins and
Kjetil Taskén and
Philippe Collas Recruitment of Protein Phosphatase 1 to
the Nuclear Envelope by a--Kinase
Anchoring Protein Akap149 Is a
Prerequisite for Nuclear Lamina Assembly 1251
Lelio Orci and
Myl\`ene Amherdt and
Mariella Ravazzola and
Alain Perrelet and
James E. Rothman Exclusion of Golgi Residents from
Transport Vesicles Budding from Golgi
Cisternae in Intact Cells . . . . . . . 1263
Alison J. Davis and
Naresh B. Sepuri and
Jason Holder and
Arthur E. Johnson and
Robert E. Jensen Two Intermembrane Space Tim Complexes
Interact with Different Domains of
Tim23p during Its Import into
Mitochondria . . . . . . . . . . . . . . 1271
Derek J. Milner and
Manolis Mavroidis and
Noah Weisleder and
Yassemi Capetanaki Desmin Cytoskeleton Linked to Muscle
Mitochondrial Distribution and
Respiratory Function . . . . . . . . . . 1283
Rajat Rohatgi and
Hsin-yi Henry Ho and
Marc W. Kirschner Mechanism of N--Wasp Activation by Cdc42
and Phosphatidylinositol
4,5-Bisphosphate . . . . . . . . . . . . 1299
Henry N. Higgs and
Thomas D. Pollard Activation by Cdc42 and Pip$_2$ of
Wiskott--Aldrich Syndrome Protein (Wasp)
Stimulates Actin Nucleation by Arp2/3
Complex . . . . . . . . . . . . . . . . 1311
Zhengshan Dai and
Xiaoyan Luo and
Hongbo Xie and
H. Benjamin Peng The Actin-Driven Movement and Formation
of Acetylcholine Receptor Clusters . . . 1321
Ritsuko Fujii and
Susumu Yamashita and
Masahiko Hibi and
Toshio Hirano Asymmetric p38 Activation in Zebrafish 1335
László Homolya and
Thomas H. Steinberg and
Richard C. Boucher Cell to Cell Communication in Response
to Mechanical Stress via Bilateral
Release of ATP and Utp in Polarized
Epithelia . . . . . . . . . . . . . . . 1349
Andreas Wodarz and
Andreas Ramrath and
Alexandra Grimm and
Elisabeth Knust Drosophila Atypical Protein Kinase C
Associates with Bazooka and Controls
Polarity of Epithelia and Neuroblasts 1361
Martin Sachs and
Henning Brohmann and
Dietmar Zechner and
Thomas Müller and
Jörg Hülsken and
Ingrid Walther and
Ute Schaeper and
Carmen Birchmeier and
Walter Birchmeier Essential Role of Gab1 for Signaling by
the C--Met Receptor in Vivo . . . . . . 1375
Marvin E. Adams and
Neal Kramarcy and
Stuart P. Krall and
Susana G. Rossi and
Richard L. Rotundo and
Robert Sealock and
Stanley C. Froehner Absence of $ \alpha $-Syntrophin Leads
to Structurally Aberrant Neuromuscular
Synapses Deficient in Utrophin . . . . . 1385
Gregory E. Crawford and
John A. Faulkner and
Rachelle H. Crosbie and
Kevin P. Campbell and
Stanley C. Froehner and
Jeffrey S. Chamberlain Assembly of the Dystrophin--Associated
Protein Complex Does Not Require the
Dystrophin Cooh--Terminal Domain . . . . 1399
Hong-Sheng Li and
Craig Montell TRP and the PDZ Protein, Inad, Form the
Core Complex Required for Retention of
the Signalplex in \bionameDrosophila
Photoreceptor Cells . . . . . . . . . . 1411
Jing Du and
Linyin Feng and
Feng Yang and
Bai Lu Activity- and Ca$^{2+}$-Dependent
Modulation of Surface Expression of
Brain-Derived Neurotrophic Factor
Receptors in Hippocampal Neurons . . . . 1423
Alla F. Fomina and
Christopher M. Fanger and
J. Ashot Kozak and
Michael D. Cahalan Single Channel Properties and Regulated
Expression of Ca$^{2+}$
Release--Activated Ca$^{2+}$ (Crac)
Channels in Human T Cells . . . . . . . 1435
Vincenzo Cirulli and
Gillian M. Beattie and
George Klier and
Mark Ellisman and
Camillo Ricordi and
Vito Quaranta and
Francine Frasier and
Jennifer K. Ishii and
Alberto Hayek and
Daniel R. Salomon Expression and Function of $ \alpha_v
\beta_3 $ and $ \alpha_v \beta_5 $
Integrins in the Developing Pancreas . . 1445
Richard L. Roll and
Eve Marie Bauman and
Joel S. Bennett and
Charles S. Abrams Phosphorylated Pleckstrin Induces Cell
Spreading via an Integrin--Dependent
Pathway . . . . . . . . . . . . . . . . 1461
Thomas Plath and
Katharina Detjen and
Martina Welzel and
Zofia von Marschall and
Derek Murphy and
Michael Schirner and
Bertram Wiedenmann and
Stefan Rosewicz A Novel Function for the Tumor
Suppressor p16$^{\rm INK4a}$ . . . . . . 1467
Gaëlle Le'Negrate and
Eric Selva and
Patrick Auberger and
Bernard Rossi and
Paul Hofman Sustained Polymorphonuclear Leukocyte
Transmigration Induces Apoptosis in T84
Intestinal Epithelial Cells . . . . . . 1479
Hui-Jun Wang and
Ginette Guay and
Liviu Pogan and
Remy Sauvé and
Ivan R. Nabi Calcium Regulates the Association
between Mitochondria and a Smooth
Subdomain of the Endoplasmic Reticulum 1489
Naoko Nagai and
Masanori Hosokawa and
Shigeyoshi Itohara and
Eijiro Adachi and
Takatoshi Matsushita and
Nobuko Hosokawa and
Kazuhiro Nagata Embryonic Lethality of Molecular
Chaperone Hsp47 Knockout Mice Is
Associated with Defects in Collagen
Biosynthesis . . . . . . . . . . . . . . 1499
Yoshiaki Kamada and
Tomoko Funakoshi and
Takahiro Shintani and
Kazuya Nagano and
Mariko Ohsumi and
Yoshinori Ohsumi Tor-Mediated Induction of Autophagy via
an Apg1 Protein Kinase Complex . . . . . 1507
Christopher M. Brennan and
Imed-Eddine Gallouzi and
Joan A. Steitz Protein Ligands to Hur Modulate Its
Interaction with Target Mrnas in Vivo 1
Heidi Browning and
Jacqueline Hayles and
Juan Mata and
Lauren Aveline and
Paul Nurse and
J. Richard McIntosh Tea2p Is a Kinesin-like Protein Required
to Generate Polarized Growth in Fission
Yeast . . . . . . . . . . . . . . . . . 15
Scott A. Weed and
Andrei V. Karginov and
Dorothy A. Schafer and
Alissa M. Weaver and
Andrew W. Kinley and
John A. Cooper and
J. Thomas Parsons Cortactin Localization to Sites of Actin
Assembly in \bionameLamellipodia
Requires Interactions with F-Actin and
the Arp2/3 Complex . . . . . . . . . . . 29
Robert W. Burgess and
William C. Skarnes and
Joshua R. Sanes Agrin Isoforms with Distinct Amino
Termini . . . . . . . . . . . . . . . . 41
Iryna M. Ethell and
Kazuki Hagihara and
Yoshiaki Miura and
Fumitoshi Irie and
Yu Yamaguchi Synbindin, a Novel Syndecan-2--Binding
Protein in Neuronal Dendritic Spines . . 53
Richard G. Gardner and
Gwendolyn M. Swarbrick and
Nathan W. Bays and
Stephen R. Cronin and
Sharon Wilhovsky and
Linda Seelig and
Christine Kim and
Randolph Y. Hampton Endoplasmic Reticulum Degradation
Requires Lumen to Cytosol Signaling . . 69
Olga Krylova and
Marcus J. Messenger and
Patricia C. Salinas Dishevelled-1 Regulates Microtubule
Stability . . . . . . . . . . . . . . . 83
Edgar Trelles-Sticken and
Michael E. Dresser and
Harry Scherthan Meiotic Telomere Protein Ndj1p Is
Required for Meiosis--Specific Telomere
Distribution, Bouquet Formation and
Efficient Homologue Pairing . . . . . . 95
Kimberly S. Straley and
Samuel A. Green Rapid Transport of Internalized
P--Selectin to Late Endosomes and the
Tgn . . . . . . . . . . . . . . . . . . 107
Syed Haq and
Gabriel Choukroun and
Zhao Bin Kang and
Hardeep Ranu and
Takashi Matsui and
Anthony Rosenzweig and
Jeffrey D. Molkentin and
Alessandro Alessandrini and
James Woodgett and
Roger Hajjar and
Ashour Michael and
Thomas Force Glycogen Synthase Kinase-3$ \beta $ Is a
Negative Regulator of Cardiomyocyte
Hypertrophy . . . . . . . . . . . . . . 117
Hong-Guo Yu and
R. Kelly Dawe Functional Redundancy in the Maize
Meiotic Kinetochore . . . . . . . . . . 131
Mikael Simons and
Eva-Maria Krämer and
Christoph Thiele and
Wilhelm Stoffel and
Jacqueline Trotter Assembly of Myelin by Association of
Proteolipid Protein with Cholesterol-
and Galactosylceramide--Rich Membrane
Domains . . . . . . . . . . . . . . . . 143
Eric L. Reese and
Leah T. Haimo Dynein, Dynactin, and Kinesin II's
Interaction with Microtubules Is
Regulated during Bidirectional Organelle
Transport . . . . . . . . . . . . . . . 155
Kathrin Plath and
Tom A. Rapoport Spontaneous Release of Cytosolic
Proteins from Posttranslational
Substrates before Their Transport into
the Endoplasmic Reticulum . . . . . . . 167
Eustratios Bananis and
John W. Murray and
Richard J. Stockert and
Peter Satir and
Allan W. Wolkoff Microtubule and Motor--Dependent
Endocytic Vesicle Sorting in Vitro . . . 179
Mark A. McNiven and
Leung Kim and
Eugene W. Krueger and
James D. Orth and
Hong Cao and
Tai Wai Wong Regulated Interactions between Dynamin
and the Actin--Binding Protein Cortactin
Modulate Cell Shape . . . . . . . . . . 187
Alexander M. van der Bliek A Mitochondrial Division Apparatus Takes
Shape . . . . . . . . . . . . . . . . . 0
Peter M. Steinert The Complexity and Redundancy of
Epithelial Barrier Function . . . . . . ??
Robert W. Doms and
John P. Moore HIV-1 Membrane Fusion . . . . . . . . . ??
Thomas Harder and
Marina Kuhn Selective Accumulation of
Raft--Associated Membrane Protein Lat in
T Cell Receptor Signaling Assemblies . . 199
Sho Tokumaru and
Shigeki Higashiyama and
Takeshi Endo and
Takatoshi Nakagawa and
Jun-ichiro Miyagawa and
Katsumi Yamamori and
Yasushi Hanakawa and
Hiroshi Ohmoto and
Kohichiro Yoshino and
Yuji Shirakata and
Yuji Matsuzawa and
Koji Hashimoto and
Naoyuki Taniguchi Ectodomain Shedding of Epidermal Growth
Factor Receptor Ligands Is Required for
Keratinocyte Migration in Cutaneous
Wound Healing . . . . . . . . . . . . . 209
Manuel Koch and
Julie R. Murrell and
Dale D. Hunter and
Pamela F. Olson and
William Jin and
Douglas R. Keene and
William J. Brunken and
Robert E. Burgeson A Novel Member of the Netrin Family, $
\beta $-Netrin, Shares Homology with the
$ \beta $ Chain of Laminin . . . . . . . 221
Peter F. M. van der Ven and
Sebastian Wiesner and
Paula Salmikangas and
Daniel Auerbach and
Mirko Himmel and
Stefan Kempa and
Katrin Hayeß and
Dirk Pacholsky and
Anu Taivainen and
Rolf Schröder and
Olli Carpén and
Dieter O. Fürst Indications for a Novel Muscular
Dystrophy Pathway . . . . . . . . . . . 235
Concepción Jiménez and
Rosario Armas Portela and
Mario Mellado and
Jose Miguel Rodríguez-Frade and
John Collard and
Antonio Serrano and
Carlos Martínez-A and
Jesus Avila and
Ana C. Carrera Role of the Pi3k Regulatory Subunit in
the Control of Actin Organization and
Cell Migration . . . . . . . . . . . . . 249
Takayoshi Kirisako and
Yoshinobu Ichimura and
Hisashi Okada and
Yukiko Kabeya and
Noboru Mizushima and
Tamotsu Yoshimori and
Mariko Ohsumi and
Toshifumi Takao and
Takeshi Noda and
Yoshinori Ohsumi The Reversible Modification Regulates
the Membrane-Binding State of Apg8/Aut7
Essential for Autophagy and the
Cytoplasm to Vacuole Targeting Pathway 263
Sachiko Kanaji and
Jun Iwahashi and
Yuichiro Kida and
Masao Sakaguchi and
Katsuyoshi Mihara Characterization of the Signal That
Directs Tom20 to the Mitochondrial Outer
Membrane . . . . . . . . . . . . . . . . 277
Wei Wang and
Michael Sacher and
Susan Ferro-Novick Trapp Stimulates Guanine Nucleotide
Exchange on Ypt1p . . . . . . . . . . . 289
Steven F. Nothwehr and
Seon-Ah Ha and
Paul Bruinsma Sorting of Yeast Membrane Proteins into
an Endosome-to-Golgi Pathway Involves
Direct Interaction of Their Cytosolic
Domains with Vps35p . . . . . . . . . . 297
Marilena Marzia and
Natalie A. Sims and
Susanne Voit and
Silvia Migliaccio and
Anna Taranta and
Silvia Bernardini and
Tullio Faraggiana and
Toshiyuki Yoneda and
Gregory R. Mundy and
Brendan F. Boyce and
Roland Baron and
Anna Teti Decreased C--Src Expression Enhances
Osteoblast Differentiation and Bone
Formation . . . . . . . . . . . . . . . 311
Cynthia M. Lane and
Ian Cushman and
Mary Shannon Moore Selective Disruption of Nuclear Import
by a Functional Mutant Nuclear Transport
Carrier . . . . . . . . . . . . . . . . 321
Peter Fekkes and
Kelly A. Shepard and
Michael P. Yaffe Gag3p, an Outer Membrane Protein
Required for Fission of Mitochondrial
Tubules . . . . . . . . . . . . . . . . 333
Edith D. Wong and
Jennifer A. Wagner and
Steven W. Gorsich and
J. Michael McCaffery and
Janet M. Shaw and
Jodi Nunnari The Dynamin--Related Gtpase, Mgm1p, Is
an Intermembrane Space Protein Required
for Maintenance of Fusion Competent
Mitochondria . . . . . . . . . . . . . . 341
Quinton Tieu and
Jodi Nunnari Mdv1p Is a Wd Repeat Protein That
Interacts with the Dynamin--Related
Gtpase, Dnm1p, to Trigger Mitochondrial
Division . . . . . . . . . . . . . . . . 353
A. D. Mozdy and
J. M. McCaffery and
J. M. Shaw Dnm1p GTPase-Mediated Mitochondrial
Fission Is a Multi-Step Process
Requiring the Novel Integral Membrane
Component Fis1p . . . . . . . . . . . . 367
Philippe Djian and
Karen Easley and
Howard Green Targeted Ablation of the Murine
Involucrin Gene . . . . . . . . . . . . 381
Peter J. Koch and
Pierre A. de Viragh and
Elisabeth Scharer and
Donnie Bundman and
Mary Ann Longley and
Jackie Bickenbach and
Yasuhiro Kawachi and
Yasushi Suga and
Zhijian Zhou and
Marcel Huber and
Daniel Hohl and
Tonja Kartasova and
Michal Jarnik and
Alasdair C. Steven and
Dennis R. Roop Lessons from Loricrin--Deficient Mice 389
Yasushi Suga and
Michal Jarnik and
Paul S. Attar and
Mary A. Longley and
Donnie Bundman and
Alasdair C. Steven and
Peter J. Koch and
Dennis R. Roop Transgenic Mice Expressing a Mutant Form
of Loricrin Reveal the Molecular Basis
of the Skin Diseases, Vohwinkel Syndrome
and Progressive Symmetric
Erythrokeratoderma . . . . . . . . . . . 401
Grigory B. Melikyan and
Ruben M. Markosyan and
Hila Hemmati and
Mary K. Delmedico and
Dennis M. Lambert and
Fredric S. Cohen Evidence That the Transition of HIV-1
Gp41 into a Six--Helix Bundle, Not the
Bundle Configuration, Induces Membrane
Fusion . . . . . . . . . . . . . . . . . 413
R. Todd Armstrong and
Anna S. Kushnir and
Judith M. White The Transmembrane Domain of Influenza
Hemagglutinin Exhibits a Stringent
Length Requirement to Support the
Hemifusion to Fusion Transition . . . . 425
Eric Grote and
Chavela M. Carr and
Peter J. Novick Ordering the Final Events in Yeast
Exocytosis . . . . . . . . . . . . . . . 439
Eric Grote and
Misuzu Baba and
Yoshinori Ohsumi and
Peter J. Novick Geranylgeranylated Snares Are Dominant
Inhibitors of Membrane Fusion . . . . . 453
Bernhard E. Flucher and
Nicole Kasielke and
Manfred Grabner The Triad Targeting Signal of the
Skeletal Muscle Calcium Channel Is
Localized in the Cooh Terminus of the $
\alpha $$_{1S}$ Subunit . . . . . . . . 467
Honglin Zhou and
Xin-Ming Li and
Judy Meinkoth and
Randall N. Pittman Akt Regulates Cell Survival and
Apoptosis at a Postmitochondrial Level 483
Florence A. Scholl and
Patricia McLoughlin and
Elisabeth Ehler and
Carla de Giovanni and
Beat W. Schäfer Dral Is a P53-Responsive Gene Whose Four
and a Half Lim Domain Protein Product
Induces Apoptosis . . . . . . . . . . . 495
Britta Brügger and
Roger Sandhoff and
Sabine Wegehingel and
Karin Gorgas and
Jörg Malsam and
J. Bernd Helms and
Wolf-Dieter Lehmann and
Walter Nickel and
Felix T. Wieland Evidence for Segregation of
Sphingomyelin and Cholesterol during
Formation of Copi--Coated Vesicles . . . 507
Oliver Müller and
Tanja Sattler and
Matthias Flötenmeyer and
Heinz Schwarz and
Helmut Plattner and
Andreas Mayer Autophagic Tubes . . . . . . . . . . . . 519
Tanja Sattler and
Andreas Mayer Cell-Free Reconstitution of
Microautophagic Vacuole Invagination and
Vesicle Formation . . . . . . . . . . . 529
M. Alejandro Barbieri and
Richard L. Roberts and
Aysel Gumusboga and
Hilary Highfield and
Carmen Alvarez-Dominguez and
Alan Wells and
Philip D. Stahl Epidermal Growth Factor and Membrane
Trafficking . . . . . . . . . . . . . . 539
Andrew E. Wurmser and
Trey K. Sato and
Scott D. Emr New Component of the Vacuolar Class
C--Vps Complex Couples Nucleotide
Exchange on the Ypt7 Gtpase to
Snare--Dependent Docking and Fusion . . 551
Yoshitaka Tamai and
Tomo-o Ishikawa and
Michael R. Bösl and
Masahiko Mori and
Masami Nozaki and
Heléne Baribault and
Robert G. Oshima and
Makoto M. Taketo Cytokeratins 8 and 19 in the Mouse
Placental Development . . . . . . . . . 563
Teresa DiColandrea and
Tadashi Karashima and
Arto Määttä and
Fiona M. Watt Subcellular Distribution of Envoplakin
and Periplakin . . . . . . . . . . . . . 573
Michael W. Black and
Hugh R. B. Pelham A Selective Transport Route from Golgi
to Late Endosomes That Requires the
Yeast Gga Proteins . . . . . . . . . . . 587
Erik Nielsen and
Savvas Christoforidis and
Sandrine Uttenweiler-Joseph and
Marta Miaczynska and
Frederique Dewitte and
Matthias Wilm and
Bernard Hoflack and
Marino Zerial Rabenosyn-5, a Novel Rab5 Effector, Is
Complexed with Hvps45 and Recruited to
Endosomes through a Fyve Finger Domain 601
Theresa Hartman and
Kristen Stead and
Douglas Koshland and
Vincent Guacci Pds5p Is an Essential Chromosomal
Protein Required for Both Sister
Chromatid Cohesion and Condensation in
\bionameSaccharomyces cerevisiae . . . . 613
Trevor R. Jackson and
Fraser D. Brown and
Zhongzhen Nie and
Koichi Miura and
Letizia Foroni and
Jianlan Sun and
Victor W. Hsu and
Julie G. Donaldson and
Paul A. Randazzo Acaps Are Arf6 Gtpase--Activating
Proteins That Function in the Cell
Periphery . . . . . . . . . . . . . . . 627
Cristina Machado and
Deborah J. Andrew D-Titin . . . . . . . . . . . . . . . . 639
Sabine Snaar and
Karien Wiesmeijer and
Aart G. Jochemsen and
Hans J. Tanke and
Roeland W. Dirks Mutational Analysis of Fibrillarin and
Its Mobility in Living Human Cells . . . 653
Shannon E. Dunn and
Eva R. Chin and
Robin N. Michel Matching of Calcineurin Activity to
Upstream Effectors Is Critical for
Skeletal Muscle Fiber Growth . . . . . . 663
Karsten Mahnke and
Ming Guo and
Sena Lee and
Homero Sepulveda and
Suzy L. Swain and
Michel Nussenzweig and
Ralph M. Steinman The Dendritic Cell Receptor for
Endocytosis, Dec-205, Can Recycle and
Enhance Antigen Presentation via Major
Histocompatibility Complex Class
II--Positive Lysosomal Compartments . . 673
Katarzyna Bialkowska and
Sucheta Kulkarni and
Xiaoping Du and
Darrel E. Goll and
Takaomi C. Saido and
Joan E. B. Fox Evidence That $ \beta $3
Integrin--Induced Rac Activation
Involves the Calpain--Dependent
Formation of Integrin Clusters That Are
Distinct from the Focal Complexes and
Focal Adhesions That Form as Rac and
Rhoa Become Active . . . . . . . . . . . 685
Angela Poperechnaya and
Olga Varlamova and
Pei-ju Lin and
James T. Stull and
Anne R. Bresnick Localization and Activity of Myosin
Light Chain Kinase Isoforms during the
Cell Cycle . . . . . . . . . . . . . . . 697
Gregory J. Pazour and
Bethany L. Dickert and
Yvonne Vucica and
E. Scott Seeley and
Joel L. Rosenbaum and
George B. Witman and
Douglas G. Cole Chlamydomonas IFT 88 and Its Mouse
Homologue, Polycystic Kidney Disease
Gene Tg 737, Are Required for Assembly
of Cilia and Flagella . . . . . . . . . 709
Maxwell G. Heiman and
Peter Walter Prm1p, a Pheromone--Regulated
Multispanning Membrane Protein,
Facilitates Plasma Membrane Fusion
during Yeast Mating . . . . . . . . . . 719
Linyi Chen and
Nicholas G. Davis Recycling of the Yeast a -Factor
Receptor . . . . . . . . . . . . . . . . 731
Helmut Krämer The Ups and Downs of Life in an
Epithelium . . . . . . . . . . . . . . . 0
Geoffrey I. McFadden Skeletons in the Closet . . . . . . . . ??
Jennifer M. King and
Tom S. Hays and
R. Bruce Nicklas Dynein Is a Transient Kinetochore
Component Whose Binding Is Regulated by
Microtubule Attachment, Not Tension . . 739
Izabela Sumara and
Elisabeth Vorlaufer and
Christian Gieffers and
Beate H. Peters and
Jan-Michael Peters Characterization of Vertebrate Cohesin
Complexes and Their Regulation in
Prophase . . . . . . . . . . . . . . . . 749
Mark R. Frey and
Jennifer A. Clark and
Olga Leontieva and
Joshua M. Uronis and
Adrian R. Black and
Jennifer D. Black Protein Kinase C Signaling Mediates a
Program of Cell Cycle Withdrawal in the
Intestinal Epithelium . . . . . . . . . 763
Yoichi Ezura and
Shukti Chakravarti and
Åke Oldberg and
Inna Chervoneva and
David E. Birk Differential Expression of Lumican and
Fibromodulin Regulate Collagen
Fibrillogenesis in Developing Mouse
Tendons . . . . . . . . . . . . . . . . 779
Wei-Lih Lee and
Magdalena Bezanilla and
Thomas D. Pollard Fission Yeast Myosin-I, Myo1p,
Stimulates Actin Assembly by Arp2/3
Complex and Shares Functions with Wasp 789
Aino Paasinen-Sohns and
Mari Kielosto and
Essi Kääriäinen and
Terho Eloranta and
Aire Laine and
Olli A. Jänne and
Michael J. Birrer and
Erkki Hölttä C-Jun Activation--Dependent Tumorigenic
Transformation Induced Paradoxically by
Overexpression or Block of S
-Adenosylmethionine Decarboxylase . . . 801
Gary A. Wayman and
Melinda J. Walters and
Kathryn Kolibaba and
Thomas R. Soderling and
Jan L. Christian CAM Kinase IV Regulates Lineage
Commitment and Survival of Erythroid
Progenitors in a Non-Cell-Autonomous
Manner . . . . . . . . . . . . . . . . . 811
Erika S. Wittchen and
Julie Haskins and
Bruce R. Stevenson Exogenous Expression of the
Amino--Terminal Half of the Tight
Junction Protein Zo-3 Perturbs
Junctional Complex Assembly . . . . . . 825
Thibault Mayor and
York-Dieter Stierhof and
Kayoko Tanaka and
Andrew M. Fry and
Erich A. Nigg The Centrosomal Protein C--Nap1 Is
Required for Cell Cycle--Regulated
Centrosome Cohesion . . . . . . . . . . 837
Alex L. Mah and
George Perry and
Mark A. Smith and
Mervyn J. Monteiro Identification of Ubiquilin, a Novel
Presenilin Interactor That Increases
Presenilin Protein Accumulation . . . . 847
Arash Komeili and
Karen P. Wedaman and
Erin K. O'Shea and
Ted Powers Mechanism of Metabolic Control . . . . . 863
Michael T. Engsig and
Qing-Jun Chen and
Thiennu H. Vu and
Anne-Cecilie Pedersen and
Bente Therkidsen and
Leif R. Lund and
Kim Henriksen and
Thomas Lenhard and
Niels T. Foged and
Zena Werb and
Jean-Marie Delaissé Matrix Metalloproteinase 9 and Vascular
Endothelial Growth Factor Are Essential
for Osteoclast Recruitment into
Developing Long Bones . . . . . . . . . 879
Guy Tanentzapf and
Christian Smith and
Jane McGlade and
Ulrich Tepass Apical, Lateral, and Basal Polarization
Cues Contribute to the Development of
the Follicular Epithelium during
\bionameDrosophila Oogenesis . . . . . . 891
John C. Sisson and
Christine Field and
Richard Ventura and
Anne Royou and
William Sullivan Lava Lamp, a Novel Peripheral Golgi
Protein, Is Required for
\bionameDrosophila melanogaster
Cellularization . . . . . . . . . . . . 905
E. J. Kamsteeg and
I. Heijnen and
C. H. van Os and
P. M. T. Deen The Subcellular Localization of an
Aquaporin-2 Tetramer Depends on the
Stoichiometry of Phosphorylated and
Nonphosphorylated Monomers . . . . . . . 919
Fernando Lecanda and
Pamela M. Warlow and
Sharmin Sheikh and
Federico Furlan and
Thomas H. Steinberg and
Roberto Civitelli Connexin43 Deficiency Causes Delayed
Ossification, Craniofacial
Abnormalities, and Osteoblast
Dysfunction . . . . . . . . . . . . . . 931
Justine Kiessling and
Sven Kruse and
Stefan A. Rensing and
Klaus Harter and
Eva L. Decker and
Ralf Reski Visualization of a Cytoskeleton-like
Ftsz Network in Chloroplasts . . . . . . 945
John D. Aitchison and
Michael P. Rout The Road to Ribosomes . . . . . . . . . 0
Edwin W. Taylor and
Gary G. Borisy Kinesin Processivity . . . . . . . . . . ??
Ahmed Zahraoui and
Daniel Louvard and
Thierry Galli Tight Junction, a Platform for
Trafficking and Signaling Protein
Complexes . . . . . . . . . . . . . . . ??
Mary E. Porter and
Winfield S. Sale The 9 + 2 Axoneme Anchors Multiple Inner
Arm Dyneins and a Network of Kinases and
Phosphatases That Control Motility . . . ??
Lavina Faleiro and
Yuri Lazebnik Caspases Disrupt the
Nuclear--Cytoplasmic Barrier . . . . . . 951
Ping Hu and
Fang-Ming Deng and
Feng-Xia Liang and
Chuan-Min Hu and
Anna B. Auerbach and
Ellen Shapiro and
Xue-Ru Wu and
Bechara Kachar and
Tung-Tien Sun Ablation of Uroplakin III Gene Results
in Small Urothelial Plaques, Urothelial
Leakage, and Vesicoureteral Reflux . . . 961
Yuval Shimoni and
Tatsuo Kurihara and
Mariella Ravazzola and
Myl\`ene Amherdt and
Lelio Orci and
Randy Schekman Lst1p and Sec24p Cooperate in Sorting of
the Plasma Membrane Atpase into Copii
Vesicles in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 973
Stanny Berghs and
Diego Aggujaro and
Ronald Dirkx and
Elena Maksimova and
Paul Stabach and
Jean-Michel Hermel and
Jian-Ping Zhang and
William Philbrick and
Vladimir Slepnev and
Tatiana Ort and
Michele Solimena $ \beta $ iv Spectrin, a New Spectrin
Localized at Axon Initial Segments and
Nodes of Ranvier in the Central and
Peripheral Nervous System . . . . . . . 985
Anne-Marie C. Yvon and
Patricia Wadsworth Region-Specific Microtubule Transport in
Motile Cells . . . . . . . . . . . . . . 1003
Ivelisse Sánchez and
Linda Hassinger and
Ram K. Sihag and
Don W. Cleveland and
Panaiyur Mohan and
Ralph A. Nixon Local Control of Neurofilament
Accumulation during Radial Growth of
Myelinating Axons in Vivo . . . . . . . 1013
Hagai Abeliovich and
William A. Dunn and
John Kim and
Daniel J. Klionsky Dissection of Autophagosome Biogenesis
into Distinct Nucleation and Expansion
Steps . . . . . . . . . . . . . . . . . 1025
Stefano C. Previtali and
Angelo Quattrini and
Marina Fasolini and
Maria Carla Panzeri and
Antonello Villa and
Marie T. Filbin and
Wenhui Li and
Shing-Yan Chiu and
Albee Messing and
Lawrence Wrabetz and
M. Laura Feltri Epitope-Tagged P$_0$ Glycoprotein Causes
Charcot--Marie--Tooth-like Neuropathy in
Transgenic Mice . . . . . . . . . . . . 1035
Shikha Laloraya and
Vincent Guacci and
Douglas Koshland Chromosomal Addresses of the Cohesin
Component Mcd1p . . . . . . . . . . . . 1047
Jennifer Hei-Ngam Ho and
George Kallstrom and
Arlen W. Johnson Nmd3p Is a Crm1p--Dependent Adapter
Protein for Nuclear Export of the Large
Ribosomal Subunit . . . . . . . . . . . 1057
Cécile Barret and
Christian Roy and
Philippe Montcourrier and
Paul Mangeat and
Verena Niggli Mutagenesis of the Phosphatidylinositol
4,5-Bisphosphate (Pip$_2$) Binding Site
in the Nh$_2$-Terminal Domain of Ezrin
Correlates with Its Altered Cellular
Distribution . . . . . . . . . . . . . . 1067
Michio Tomishige and
Ronald D. Vale Controlling Kinesin by Reversible
Disulfide Cross--Linking . . . . . . . . 1081
Kurt S. Thorn and
Jeffrey A. Ubersax and
Ronald D. Vale Engineering the Processive Run Length of
the Kinesin Motor . . . . . . . . . . . 1093
Ursula Fleig and
Sandra S. Salus and
Inga Karig and
Shelley Sazer The Fission Yeast Ran Gtpase Is Required
for Microtubule Integrity . . . . . . . 1101
Richard D. Shelby and
Karine Monier and
Kevin F. Sullivan Chromatin Assembly at Kinetochores Is
Uncoupled from DNA Replication . . . . . 1113
Noureddine Zebda and
Ora Bernard and
Maryse Bailly and
Susan Welti and
David S. Lawrence and
John S. Condeelis Phosphorylation of Adf/Cofilin Abolishes
Egf-Induced Actin Nucleation at the
Leading Edge and Subsequent Lamellipod
Extension . . . . . . . . . . . . . . . 1119
Jeffrey S. Chamberlain Muscular Dystrophy Meets the Gene Chip 0
Margaret A. Lawlor and
Peter Rotwein Coordinate Control of Muscle Cell
Survival by Distinct Insulin-like Growth
Factor Activated Signaling Pathways . . 1131
Suresh K. Alahari and
Jung Weon Lee and
Rudy L. Juliano Nischarin, a Novel Protein That
Interacts with the Integrin $ \alpha $5
Subunit and Inhibits Cell Migration . . 1141
Robert D. Moir and
Miri Yoon and
Satya Khuon and
Robert D. Goldman Nuclear Lamins a and B1 . . . . . . . . 1155
Arabella Meixner and
Silke Haverkamp and
Heinz Wässle and
Susanne Führer and
Johann Thalhammer and
Nina Kropf and
Reginald E. Bittner and
Hans Lassmann and
Gerhard Wiche and
Friedrich Propst Map1b Is Required for Axon Guidance and
Is Involved in the Development of the
Central and Peripheral Nervous System 1169
Hadas Reuveni and
Tamar Geiger and
Benjamin Geiger and
Alexander Levitzki Reversal of the Ras-Induced Transformed
Phenotype by Hr12, a Novel Ras
Farnesylation Inhibitor, Is Mediated by
the Mek/ERK Pathway . . . . . . . . . . 1179
Jae-Beom Kim and
Shahidul Islam and
Young J. Kim and
Ryan S. Prudoff and
Kristin M. Sass and
Margaret J. Wheelock and
Keith R. Johnson N-Cadherin Extracellular Repeat 4
Mediates Epithelial to Mesenchymal
Transition and Increased Motility . . . 1193
Mona Wilcke and
Ludger Johannes and
Thierry Galli and
Véronique Mayau and
Bruno Goud and
Jean Salamero Rab11 Regulates the Compartmentalization
of Early Endosomes Required for
Efficient Transport from Early Endosomes
to the Trans-Golgi Network . . . . . . . 1207
Jonathan R. Beauchamp and
Louise Heslop and
David S. W. Yu and
Shahragim Tajbakhsh and
Robert G. Kelly and
Anton Wernig and
Margaret E. Buckingham and
Terence A. Partridge and
Peter S. Zammit Expression of Cd34 and Myf5 Defines the
Majority of Quiescent Adult Skeletal
Muscle Satellite Cells . . . . . . . . . 1221
Chinami Hikita and
Soundarapandian Vijayakumar and
Jiro Takito and
Hediyet Erdjument-Bromage and
Paul Tempst and
Qais Al-Awqati Induction of Terminal Differentiation in
Epithelial Cells Requires Polymerization
of Hensin by Galectin 3 . . . . . . . . 1235
Hirotaka Matsumura and
Yusuke Shimizu and
Yoshiyuki Ohsawa and
Atsuo Kawahara and
Yasuo Uchiyama and
Shigekazu Nagata Necrotic Death Pathway in FAS Receptor
Signaling . . . . . . . . . . . . . . . 1247
Nancy Kedersha and
Michael R. Cho and
Wei Li and
Patrick W. Yacono and
Samantha Chen and
Natalie Gilks and
David E. Golan and
Paul Anderson Dynamic Shuttling of Tia-1 Accompanies
the Recruitment of mRNA to Mammalian
Stress Granules . . . . . . . . . . . . 1257
Jason M. Haugh and
Franca Codazzi and
Mary Teruel and
Tobias Meyer Spatial Sensing in Fibroblasts Mediated
by 3' Phosphoinositides . . . . . . . . 1269
Nathalie Signoret and
Annegret Pelchen-Matthews and
Matthias Mack and
Amanda E. I. Proudfoot and
Mark Marsh Endocytosis and Recycling of the HIV
Coreceptor Ccr5 . . . . . . . . . . . . 1281
Alessandro Porrello and
Maria Antonietta Cerone and
Sabrina Coen and
Aymone Gurtner and
Giulia Fontemaggi and
Letizia Cimino and
Giulia Piaggio and
Ada Sacchi and
Silvia Soddu P53 Regulates Myogenesis by Triggering
the Differentiation Activity of Prb . . 1295
Ben B. Whitlock and
Shyra Gardai and
Valerie Fadok and
Donna Bratton and
Peter M. Henson Differential Roles for $ \alpha $$_M$ $
\beta_2$ Integrin Clustering or
Activation in the Control of Apoptosis
via Regulation of Akt and ERK Survival
Mechanisms . . . . . . . . . . . . . . . 1305
Yi-Wen Chen and
Po Zhao and
Rehannah Borup and
Eric P. Hoffman Expression Profiling in the Muscular
Dystrophies . . . . . . . . . . . . . . 1321
Richard A. Heil-Chapdelaine and
Jessica R. Oberle and
John A. Cooper The Cortical Protein Num1p Is Essential
for Dynein--Dependent Interactions of
Microtubules with the Cortex . . . . . . 1337
Elisa Santolini and
Claudia Puri and
Anna Elisabetta Salcini and
Maria Cristina Gagliani and
Pier Giuseppe Pelicci and
Carlo Tacchetti and
Pier Paolo Di Fiore Numb Is an Endocytic Protein . . . . . . 1345
Roberto J. Botelho and
Mary Teruel and
Renee Dierckman and
Richard Anderson and
Alan Wells and
John D. York and
Tobias Meyer and
Sergio Grinstein Localized Biphasic Changes in
Phosphatidylinositol-4,5-Bisphosphate at
Sites of Phagocytosis . . . . . . . . . 1353
Beatrice M. Tam and
Orson L. Moritz and
Lawrence B. Hurd and
David S. Papermaster Identification of an Outer Segment
Targeting Signal in the Cooh Terminus of
Rhodopsin Using Transgenic
\bionameXenopus laevis . . . . . . . . . 1369
Linda B. Schultz and
Nabil H. Chehab and
Asra Malikzay and
Thanos D. Halazonetis P53 Binding Protein 1 (53bp1) Is an
Early Participant in the Cellular
Response to DNA Double--Strand Breaks 1381
Jesse J. Smith and
Erica K. Evans and
Monica Murakami and
Mary B. Moyer and
M. Arthur Moseley and
George Vande Woude and
Sally Kornbluth Wee1-Regulated Apoptosis Mediated by the
Crk Adaptor Protein in \bionameXenopus
Egg Extracts . . . . . . . . . . . . . . 1391
Diana L. Walker and
Dong Wang and
Ye Jin and
Uttama Rath and
Yanming Wang and
Jòrgen Johansen and
Kristen M. Johansen Skeletor, a Novel Chromosomal Protein
That Redistributes during Mitosis
Provides Evidence for the Formation of a
Spindle Matrix . . . . . . . . . . . . . 1401
Erik H. J. Danen and
Petra Sonneveld and
Arnoud Sonnenberg and
Kenneth M. Yamada Dual Stimulation of
Ras/Mitogen-Activated Protein Kinase and
Rhoa by Cell Adhesion to Fibronectin
Supports Growth Factor-Stimulated Cell
Cycle Progression . . . . . . . . . . . 1413
Boris Striepen and
Michael J. Crawford and
Michael K. Shaw and
Lewis G. Tilney and
Frank Seeber and
David S. Roos The Plastid of Toxoplasma gondii Is
Divided by Association with the
Centrosomes . . . . . . . . . . . . . . 1423
Sotiris N. Nikolopoulos and
Christopher E. Turner Actopaxin, a New Focal Adhesion Protein
That Binds Paxillin Ld Motifs and Actin
and Regulates Cell Adhesion . . . . . . 1435
Mary Ann Sells and
Amanda Pfaff and
Jonathan Chernoff Temporal and Spatial Distribution of
Activated Pak1 in Fibroblasts . . . . . 1449
He Wang and
David A. D. Parry and
Leslie N. Jones and
William W. Idler and
Lyuben N. Marekov and
Peter M. Steinert In Vitro Assembly and Structure of
Trichocyte Keratin Intermediate
Filaments . . . . . . . . . . . . . . . 1459
Andy Golden and
Penny L. Sadler and
Matthew R. Wallenfang and
Jill M. Schumacher and
Danielle R. Hamill and
Gayle Bates and
Bruce Bowerman and
Geraldine Seydoux and
Diane C. Shakes Metaphase to Anaphase (mat)
Transition--Defective Mutants in
\bionameCaenorhabditis elegans . . . . . 1469
Mary C. Reedy and
Belinda Bullard and
Jim O. Vigoreaux Flightin Is Essential for Thick Filament
Assembly and Sarcomere Stability in
\bionameDrosophila Flight Muscles . . . 1483
Matthew Lord and
Melody C. Yang and
Michelle Mischke and
John Chant Cell Cycle Programs of Gene Expression
Control Morphogenetic Protein
Localization . . . . . . . . . . . . . . 1501
Ruwanthi N. Gunawardane and
Ona C. Martin and
Kan Cao and
Lijun Zhang and
Kimberly Dej and
Akihiro Iwamatsu and
Yixian Zheng Characterization and Reconstitution of
\bionameDrosophila $ \gamma $-Tubulin
Ring Complex Subunits . . . . . . . . . 1513
Lijun Zhang and
Thomas J. Keating and
Andrew Wilde and
Gary G. Borisy and
Yixian Zheng The Role of Xgrip210 in $ \gamma
$-Tubulin Ring Complex Assembly and
Centrosome Recruitment . . . . . . . . . 1525
Rolf Heumann and
Christoph Goemans and
Daniela Bartsch and
Kurt Lingenhöhl and
Peter C. Waldmeier and
Bastian Hengerer and
Peter R. Allegrini and
Karl Schellander and
Erwin F. Wagner and
Thomas Arendt and
Rigobert H. Kamdem and
Kirstin Obst-Pernberg and
Frank Narz and
Petra Wahle and
Hartmut Berns Transgenic Activation of Ras in Neurons
Promotes Hypertrophy and Protects from
Lesion--Induced Degeneration . . . . . . 1537
Allison L. Berrier and
Anthony M. Mastrangelo and
Julian Downward and
Mark Ginsberg and
Susan E. LaFlamme Activated R--Ras, Rac1, Pi 3-Kinase and
Pkc$ \epsilon $ Can Each Restore Cell
Spreading Inhibited by Isolated Integrin
$ \beta $1 Cytoplasmic Domains . . . . . 1549
Melpomeni Platani and
Ilya Goldberg and
Jason R. Swedlow and
Angus I. Lamond In Vivo Analysis of Cajal Body Movement,
Separation, and Joining in Live Human
Cells . . . . . . . . . . . . . . . . . 1561
Dimitrios A. Skoufias and
Cristiana Mollinari and
Françoise B. Lacroix and
Robert L. Margolis Human Survivin Is a
Kinetochore--Associated Passenger
Protein . . . . . . . . . . . . . . . . 1575
Isabelle Richard and
Carinne Roudaut and
Sylvie Marchand and
Stephen Baghdiguian and
Muriel Herasse and
Daniel Stockholm and
Yasuko Ono and
Laurence Suel and
Nathalie Bourg and
Hiroyuki Sorimachi and
Gérard Lefranc and
Michel Fardeau and
Alain Sébille and
Jacques S. Beckmann Loss of Calpain 3 Proteolytic Activity
Leads to Muscular Dystrophy and to
Apoptosis-Associated I$ \kappa $ b$
\alpha $/Nuclear Factor $ \kappa $ b
Pathway Perturbation in Mice . . . . . . 1583
Arunas A. Gineitis and
Irina A. Zalenskaya and
Peter M. Yau and
E. Morton Bradbury and
Andrei O. Zalensky Human Sperm Telomere--Binding Complex
Involves Histone H2b and Secures
Telomere Membrane Attachment . . . . . . 1591
Eva Nogales and
Nikolaus Grigorieff Molecular Machines . . . . . . . . . . . 0
Sari Ben-Yaacov and
Roland Le Borgne and
Irit Abramson and
François Schweisguth and
Eyal D. Schejter Wasp, the \bionameDrosophila
Wiskott--Aldrich Syndrome Gene
Homologue, Is Required for Cell Fate
Decisions Mediated by Notch Signaling 1
J. Julian Blow and
Peter J. Gillespie and
Dennis Francis and
Dean A. Jackson Replication Origins in \bionameXenopus
Egg Extract Are 5--15 Kilobases Apart
and Are Activated in Clusters That Fire
at Different Times . . . . . . . . . . . 15
Sanne Jensen and
Marisa Segal and
Duncan J. Clarke and
Steven I. Reed A Novel Role of the Budding Yeast
Separin Esp1 in Anaphase Spindle
Elongation . . . . . . . . . . . . . . . 27
Stefan Hillmer and
Ali Movafeghi and
David G. Robinson and
Giselbert Hinz Vacuolar Storage Proteins Are Sorted in
the Cis--Cisternae of the Pea Cotyledon
Golgi Apparatus . . . . . . . . . . . . 41
John Kim and
Wei-Pang Huang and
Daniel J. Klionsky Membrane Recruitment of Aut7p in the
Autophagy and Cytoplasm to Vacuole
Targeting Pathways Requires Aut1p,
Aut2p, and the Autophagy Conjugation
Complex . . . . . . . . . . . . . . . . 51
Tieming Zhao and
Peter J. Newman Integrin Activation by Regulated
Dimerization and Oligomerization of
Platelet Endothelial Cell Adhesion
Molecule (Pecam)-1 from within the Cell 65
Livio Pellizzoni and
Bernard Charroux and
Juri Rappsilber and
Matthias Mann and
Gideon Dreyfuss A Functional Interaction between the
Survival Motor Neuron Complex and RNA
Polymerase II . . . . . . . . . . . . . 75
Shaoqiong Chen and
Denis C. Guttridge and
Zongbing You and
Zhaochen Zhang and
Andrew Fribley and
Marty W. Mayo and
Jan Kitajewski and
Cun-Yu Wang WNT-1 Signaling Inhibits Apoptosis by
Activating $ \beta $-Catenin/T Cell
Factor-Mediated Transcription . . . . . 87
Candice K. Klingbeil and
Christof R. Hauck and
Datsun A. Hsia and
K. C. Jones and
Shannon R. Reider and
David D. Schlaepfer Targeting Pyk2 to $ \beta
$1--Integrin--Containing Focal Contacts
Rescues Fibronectin--Stimulated
Signaling and Haptotactic Motility
Defects of Focal Adhesion Kinase--Null
Cells . . . . . . . . . . . . . . . . . 97
David Michaelson and
Joseph Silletti and
Gretchen Murphy and
Peter D'Eustachio and
Mark Rush and
Mark R. Philips Differential Localization of Rho Gtpases
in Live Cells . . . . . . . . . . . . . 111
James M. Holaska and
Ben E. Black and
Dona C. Love and
John A. Hanover and
John Leszyk and
Bryce M. Paschal Calreticulin Is a Receptor for Nuclear
Export . . . . . . . . . . . . . . . . . 127
Ben E. Black and
James M. Holaska and
Lyne Lévesque and
Batool Ossareh-Nazari and
Carol Gwizdek and
Catherine Dargemont and
Bryce M. Paschal Nxt1 Is Necessary for the Terminal Step
of Crm1-Mediated Nuclear Export . . . . 141
Valerie A. Kickhoefer and
Yie Liu and
Lawrence B. Kong and
Bryan E. Snow and
Phoebe L. Stewart and
Lea Harrington and
Leonard H. Rome The Telomerase/Vault-Associated Protein
Tep1 Is Required for Vault RNA Stability
and Its Association with the Vault
Particle . . . . . . . . . . . . . . . . 157
Jérome Garin and
Roberto Diez and
Sylvie Kieffer and
Jean-François Dermine and
Sophie Duclos and
Etienne Gagnon and
Remy Sadoul and
Christiane Rondeau and
Michel Desjardins The Phagosome Proteome . . . . . . . . . 165
Archana Sanjay and
Adam Houghton and
Lynn Neff and
Emilia DiDomenico and
Chantal Bardelay and
Evelyne Antoine and
Joan Levy and
James Gailit and
David Bowtell and
William C. Horne and
Roland Baron Cbl Associates with Pyk2 and Src to
Regulate Src Kinase Activity, $ \alpha_v
\beta_3 $ Integrin-Mediated Signaling,
Cell Adhesion, and Osteoclast Motility 181
Iain M. Cheeseman and
Maria Enquist-Newman and
Thomas Müller-Reichert and
David G. Drubin and
Georjana Barnes Mitotic Spindle Integrity and
Kinetochore Function Linked by the
Duo1p/Dam1p Complex . . . . . . . . . . 197
Meir Aridor and
Kenneth N. Fish and
Sergei Bannykh and
Jacques Weissman and
Theresa H. Roberts and
Jennifer Lippincott-Schwartz and
William E. Balch The Sar1 Gtpase Coordinates Biosynthetic
Cargo Selection with Endoplasmic
Reticulum Export Site Assembly . . . . . 213
Laurie G. Smith and
Suzanne M. Gerttula and
Shengcheng Han and
Joshua Levy Tangled1 . . . . . . . . . . . . . . . . 231
David M. Gilbert Nuclear Position Leaves Its Mark on
Replication Timing . . . . . . . . . . . 0
Shigeomi Shimizu and
Yosuke Matsuoka and
Yasuo Shinohara and
Yoshihiro Yoneda and
Yoshihide Tsujimoto Essential Role of Voltage--Dependent
Anion Channel in Various Forms of
Apoptosis in Mammalian Cells . . . . . . 237
Marian Farkasovsky and
Hans Küntzel Cortical Num1p Interacts with the Dynein
Intermediate Chain Pac11p and
Cytoplasmic Microtubules in Budding
Yeast . . . . . . . . . . . . . . . . . 251
Michael F. Crouch and
Deborah A. Davy and
Francis S. Willard and
Leise A. Berven Activation of Endogenous Thrombin
Receptors Causes Clustering and
Sensitization of Epidermal Growth Factor
Receptors of Swiss 3t3 Cells without
Transactivation . . . . . . . . . . . . 263
Akira Kawasaki and
Itaru Matsumura and
Jun-ichiro Miyagawa and
Sachiko Ezoe and
Hirokazu Tanaka and
Yasuhiko Terada and
Masaaki Tatsuka and
Takashi Machii and
Hiroshi Miyazaki and
Yusuke Furukawa and
Yuzuru Kanakura Downregulation of an Aim-1 Kinase
Couples with Megakaryocytic
Polyploidization of Human Hematopoietic
Cells . . . . . . . . . . . . . . . . . 275
Thomas Krimmer and
Doron Rapaport and
Michael T. Ryan and
Chris Meisinger and
C. Kenneth Kassenbrock and
Elizabeth Blachly-Dyson and
Michael Forte and
Michael G. Douglas and
Walter Neupert and
Frank E. Nargang and
Nikolaus Pfanner Biogenesis of Porin of the Outer
Mitochondrial Membrane Involves an
Import Pathway via Receptors and the
General Import Pore of the Tom Complex 289
Stefano Carenini and
Mathias Mäurer and
Alexander Werner and
Heinrich Blazyca and
Klaus V. Toyka and
Christoph D. Schmid and
Gennadij Raivich and
Rudolf Martini The Role of Macrophages in Demyelinating
Peripheral Nervous System of Mice
Heterozygously Deficient in P0 . . . . . 301
Elaine Hill and
Jeroen van der Kaay and
C. Peter Downes and
Elizabeth Smythe The Role of Dynamin and Its Binding
Partners in Coated Pit Invagination and
Scission . . . . . . . . . . . . . . . . 309
Heike Keilhack and
Marit Müller and
Sylvia-Annette Böhmer and
Carsten Frank and
K. Michael Weidner and
Walter Birchmeier and
Tanja Ligensa and
Alexander Berndt and
Hartwig Kosmehl and
Bernd Günther and
Thomas Müller and
Carmen Birchmeier and
Frank D. Böhmer Negative Regulation of Ros Receptor
Tyrosine Kinase Signaling . . . . . . . 325
Yuan Torrente and
Jacques-P Tremblay and
Federica Pisati and
Marzia Belicchi and
Barbara Rossi and
Manuela Sironi and
Franco Fortunato and
Mostafa El Fahime and
Maria Grazia D'Angelo and
Nicolas J. Caron and
Gabriela Constantin and
Denise Paulin and
Guglielmo Scarlato and
Nereo Bresolin Intraarterial Injection of
Muscle--Derived Cd34$^+$ Sca-1$^+$ Stem
Cells Restores Dystrophin in mdx Mice 335
Philip A. Wigge and
John V. Kilmartin The Ndc80p Complex from
\bionameSaccharomyces cerevisiae
Contains Conserved Centromere Components
and Has a Function in Chromosome
Segregation . . . . . . . . . . . . . . 349
Ichiro Nakamura and
Lorraine Lipfert and
Gideon A. Rodan and
Le T. Duong Convergence of $ \alpha_v \beta_3 $
Integrin- and Macrophage Colony
Stimulating Factor-Mediated Signals on
Phospholipase C$ \gamma $ in Prefusion
Osteoclasts . . . . . . . . . . . . . . 361
Brian P. Chadwick and
Huntington F. Willard A Novel Chromatin Protein, Distantly
Related to Histone H2a, Is Largely
Excluded from the Inactive X Chromosome 375
Patrick Heun and
Thierry Laroche and
M. K. Raghuraman and
Susan M. Gasser The Positioning and Dynamics of Origins
of Replication in the Budding Yeast
Nucleus . . . . . . . . . . . . . . . . 385
Alyson E. Aiken Hobbs and
Maithreyan Srinivasan and
J. Michael McCaffery and
Robert E. Jensen Mmm1p, a Mitochondrial Outer Membrane
Protein, Is Connected to Mitochondrial
DNA (Mtdna) Nucleoids and Required for
Mtdna Stability . . . . . . . . . . . . 401
Iris Ben-Efraim and
Larry Gerace Gradient of Increasing Affinity of
Importin $ \beta $ for Nucleoporins
along the Pathway of Nuclear Import . . 411
Michael B. Gordon and
Louisa Howard and
Duane A. Compton Chromosome Movement in Mitosis Requires
Microtubule Anchorage at Spindle Poles 425
Christian Jacobson and
Patrice D. Côté and
Susana G. Rossi and
Richard L. Rotundo and
Salvatore Carbonetto The Dystroglycan Complex Is Necessary
for Stabilization of Acetylcholine
Receptor Clusters at Neuromuscular
Junctions and Formation of the Synaptic
Basement Membrane . . . . . . . . . . . 435
Sukgil Song and
Kyung S. Lee A Novel Function of
\bionameSaccharomyces cerevisiae CDC5 in
Cytokinesis . . . . . . . . . . . . . . 451
Maiko Fukuoka and
Shiro Suetsugu and
Hiroaki Miki and
Kiyoko Fukami and
Takeshi Endo and
Tadaomi Takenawa A Novel Neural Wiskott--Aldrich Syndrome
Protein (N--Wasp) Binding Protein, Wish,
Induces Arp2/3 Complex Activation
Independent of Cdc42 . . . . . . . . . . 471
Paul G. Ekert and
John Silke and
Christine J. Hawkins and
Anne M. Verhagen and
David L. Vaux Diablo Promotes Apoptosis by Removing
Miha/Xiap from Processed Caspase 9 . . . 483
Anke Reinacher-Schick and
Barry M. Gumbiner Apical Membrane Localization of the
Adenomatous Polyposis Coli Tumor
Suppressor Protein and Subcellular
Distribution of the $ \beta $-Catenin
Destruction Complex in Polarized
Epithelial Cells . . . . . . . . . . . . 491
Stefan Otte and
William J. Belden and
Matthew Heidtman and
Jay Liu and
Ole N. Jensen and
Charles Barlowe Erv41p and Erv46p . . . . . . . . . . . 503
Akio Kihara and
Takeshi Noda and
Naotada Ishihara and
Yoshinori Ohsumi Two Distinct Vps34 Phosphatidylinositol
3--Kinase Complexes Function in
Autophagy and Carboxypeptidase Y Sorting
in \bionameSaccharomyces cerevisiae . . 519
Farhah F. Assaad and
Yoann Huet and
Ulrike Mayer and
Gerd Jürgens The Cytokinesis Gene KEULE Encodes a
Sec1 Protein That Binds the Syntaxin
Knolle . . . . . . . . . . . . . . . . . 531
Tord A. Hjalt and
Brad A. Amendt and
Jeffrey C. Murray Pitx2 Regulates Procollagen Lysyl
Hydroxylase (Plod) Gene Expression . . . 545
Per Nòrgaard and
Vibeke Westphal and
Christine Tachibana and
Lene Alsòe and
Bjòrn Holst and
Jakob R. Winther Functional Differences in Yeast Protein
Disulfide Isomerases . . . . . . . . . . 553
Matthias Reiss and
Nicola Viebig and
Susan Brecht and
Marie-Noelle Fourmaux and
Martine Soete and
Manlio Di Cristina and
Jean François Dubremetz and
Dominique Soldati Identification and Characterization of
an Escorter for Two Secretory Adhesins
in \bionameToxoplasma gondii . . . . . . 563
Sheila Govind and
Robert Kozma and
Clinton Monfries and
Louis Lim and
Sohail Ahmed Cdc42hs Facilitates Cytoskeletal
Reorganization and Neurite Outgrowth by
Localizing the 58-Kd Insulin Receptor
Substrate to Filamentous Actin . . . . . 579
Heike Fölsch and
Marc Pypaert and
Peter Schu and
Ira Mellman Distribution and Function of Ap-1
Clathrin Adaptor Complexes in Polarized
Epithelial Cells . . . . . . . . . . . . 595
Sherri L. Newmyer and
Sandra L. Schmid Dominant-Interfering Hsc70 Mutants
Disrupt Multiple Stages of the
Clathrin--Coated Vesicle Cycle in Vivo 607
Saskia van Es and
Deborah Wessels and
David R. Soll and
Jane Borleis and
Peter N. Devreotes Tortoise, a Novel Mitochondrial Protein,
Is Required for Directional Responses of
\bionameDictyostelium in Chemotactic
Gradients . . . . . . . . . . . . . . . 621
Fawzi Aoudjit and
Kristiina Vuori Matrix Attachment Regulates FAS--Induced
Apoptosis in Endothelial Cells . . . . . 633
Meral J. Arin and
Mary Ann Longley and
Xiao-Jing Wang and
Dennis R. Roop Focal Activation of a Mutant Allele
Defines the Role of Stem Cells in Mosaic
Skin Disorders . . . . . . . . . . . . . 645
Tongyu Cao and
Mary Ann Longley and
Xiao-Jing Wang and
Dennis R. Roop An Inducible Mouse Model for
Epidermolysis Bullosa Simplex . . . . . 651
Bart De Strooper and
Wim Annaert Where Notch and WNT Signaling Meet . . . 0
Sean W. Deacon and
Vladimir I. Gelfand Of Yeast, Mice, and Men . . . . . . . . ??
Noboru Mizushima and
Akitsugu Yamamoto and
Masahiko Hatano and
Yoshinori Kobayashi and
Yukiko Kabeya and
Kuninori Suzuki and
Takeshi Tokuhisa and
Yoshinori Ohsumi and
Tamotsu Yoshimori Dissection of Autophagosome Formation
Using Apg5-Deficient Mouse Embryonic
Stem Cells . . . . . . . . . . . . . . . 657
Régis Giet and
David M. Glover Drosophila Aurora B Kinase Is Required
for Histone H3 Phosphorylation and
Condensin Recruitment during Chromosome
Condensation and to Organize the Central
Spindle during Cytokinesis . . . . . . . 669
Stefan Fritz and
Doron Rapaport and
Elisabeth Klanner and
Walter Neupert and
Benedikt Westermann Connection of the Mitochondrial Outer
and Inner Membranes by Fzo1 Is Critical
for Organellar Fusion . . . . . . . . . 683
Caroline M. Alexander and
Sushma Selvarajan and
John Mudgett and
Zena Werb Stromelysin-1 Regulates Adipogenesis
during Mammary Gland Involution . . . . 693
Jeanne L. Dul and
David P. Davis and
Edward K. Williamson and
Fred J. Stevens and
Yair Argon Hsp70 and Antifibrillogenic Peptides
Promote Degradation and Inhibit
Intracellular Aggregation of
Amyloidogenic Light Chains . . . . . . . 705
Claire Bony and
Serge Roche and
Ueno Shuichi and
Takehiko Sasaki and
Michael A. Crackower and
Josef Penninger and
Hiroyuki Mano and
Michel Pucéat A Specific Role of Phosphatidylinositol
3--Kinase $ \gamma $ . . . . . . . . . . 717
Kimihisa Yoshida and
Günter Blobel The Karyopherin Kap142p/Msn5p Mediates
Nuclear Import and Nuclear Export of
Different Cargo Proteins . . . . . . . . 729
Donna J. Webb and
Keena S. Thomas and
Steven L. Gonias Plasminogen Activator Inhibitor 1
Functions as a Urokinase Response
Modifier at the Level of Cell Signaling
and Thereby Promotes Mcf-7 Cell Growth 741
Nguyen Truc Bui and
Antonia Livolsi and
Jean-François Peyron and
Jochen H. M. Prehn Activation of Nuclear Factor $ \kappa $
b and bcl-x Survival Gene Expression by
Nerve Growth Factor Requires Tyrosine
Phosphorylation of I$ \kappa $B$ \alpha
$ . . . . . . . . . . . . . . . . . . . 753
Winfried Wunderlich and
Irene Fialka and
David Teis and
Arno Alpi and
Andrea Pfeifer and
Robert G. Parton and
Friedrich Lottspeich and
Lukas A. Huber A Novel 14-Kilodalton Protein Interacts
with the Mitogen-Activated Protein
Kinase Scaffold Mp1 on a Late
Endosomal/Lysosomal Compartment . . . . 765
Khalid Bajou and
Véronique Masson and
Robert D. Gerard and
Petra M. Schmitt and
Valérie Albert and
Michael Praus and
Leif R. Lund and
Thomas L. Frandsen and
Nils Brunner and
Keld Dano and
Norbert E. Fusenig and
Ulrich Weidle and
Geert Carmeliet and
David Loskutoff and
Desiré Collen and
Peter Carmeliet and
Jean Michel Foidart and
Agn\`es Noël The Plasminogen Activator Inhibitor
PAI-1 Controls in Vivo Tumor
Vascularization by Interaction with
Proteases, Not Vitronectin . . . . . . . 777
Salvador Soriano and
David E. Kang and
Maofu Fu and
Richard Pestell and
Nathalie Chevallier and
Hui Zheng and
Edward H. Koo Presenilin 1 Negatively Regulates $
\beta $-Catenin/T Cell Factor/Lymphoid
Enhancer Factor-1 Signaling
Independently of $ \beta $-Amyloid
Precursor Protein and Notch Processing 785
Alistair N. Hume and
Lucy M. Collinson and
Andrzej Rapak and
Anita Q. Gomes and
Colin R. Hopkins and
Miguel C. Seabra Rab27a Regulates the Peripheral
Distribution of Melanosomes in
Melanocytes . . . . . . . . . . . . . . 795
Graça Raposo and
Danielle Tenza and
Diane M. Murphy and
Joanne F. Berson and
Michael S. Marks Distinct Protein Sorting and
Localization to Premelanosomes,
Melanosomes, and Lysosomes in Pigmented
Melanocytic Cells . . . . . . . . . . . 809
Jane C. Stinchcombe and
Duarte C. Barral and
Emilie H. Mules and
Sarah Booth and
Alistair N. Hume and
Laura M. Machesky and
Miguel C. Seabra and
Gillian M. Griffiths Rab27a Is Required for Regulated
Secretion in Cytotoxic T Lymphocytes . . 825
Elias K. Haddad and
Xufeng Wu and
John A. Hammer and
Pierre A. Henkart Defective Granule Exocytosis in
Rab27a--Deficient Lymphocytes from Ashen
Mice . . . . . . . . . . . . . . . . . . 835
Philippe Bahadoran and
Edith Aberdam and
Frédéric Mantoux and
Roser Busc\`a and
Karine Bille and
Nevin Yalman and
Genevi\`eve de Saint-Basile and
Ricardo Casaroli-Marano and
Jean-Paul Ortonne and
Robert Ballotti Rab27a . . . . . . . . . . . . . . . . . 843
Jill L. Johnson and
Elizabeth A. Craig An Essential Role for the
Substrate--Binding Region of Hsp40s in
\bionameSaccharomyces cerevisiae . . . . 851
P. J. Hollenbeck Kinesin Delivers . . . . . . . . . . . . 0
Gerrit van Meer Caveolin, Cholesterol, and Lipid
Droplets? . . . . . . . . . . . . . . . ??
Betty Y. Poon and
Christopher A. Ward and
Conan B. Cooper and
Wayne R. Giles and
Alan R. Burns and
Paul Kubes $ \alpha $$_4$ -Integrin Mediates
Neutrophil--Induced Free Radical Injury
to Cardiac Myocytes . . . . . . . . . . 857
Masaya Yamamoto and
Donald H. Hilgemann and
Siyi Feng and
Haruhiko Bito and
Hisamitsu Ishihara and
Yoshikazu Shibasaki and
Helen L. Yin Phosphatidylinositol 4,5-Bisphosphate
Induces Actin Stress--Fiber Formation
and Inhibits Membrane Ruffling in Cv1
Cells . . . . . . . . . . . . . . . . . 867
Ya-sheng Gao and
Elizabeth Sztul A Novel Interaction of the Golgi Complex
with the Vimentin Intermediate Filament
Cytoskeleton . . . . . . . . . . . . . . 877
Wilma Hofmann and
Beate Reichart and
Andrea Ewald and
Eleonora Müller and
Iris Schmitt and
Roland H. Stauber and
Friedrich Lottspeich and
Brigitte M. Jockusch and
Ulrich Scheer and
Joachim Hauber and
Marie-Christine Dabauvalle Cofactor Requirements for Nuclear Export
of Rev Response Element (Rre)--And
Constitutive Transport Element
(Cte)--Containing Retroviral RNAs . . . 895
Lasse Lehnert and
Markus M. Lerch and
Yohei Hirai and
Marie-Luise Kruse and
Wolff Schmiegel and
Holger Kalthoff Autocrine Stimulation of Human
Pancreatic Duct-like Development by
Soluble Isoforms of Epimorphin in Vitro 911
Jason H. Walenta and
Aaron J. Didier and
Xinran Liu and
Helmut Krämer The Golgi--Associated Hook3 Protein Is a
Member of a Novel Family of
Microtubule--Binding Proteins . . . . . 923
Ken Sato and
Miyuki Sato and
Akihiko Nakano Rer1p, a Retrieval Receptor for
Endoplasmic Reticulum Membrane Proteins,
Is Dynamically Localized to the Golgi
Apparatus by Coatomer . . . . . . . . . 935
Viji Mythily Draviam and
Simona Orrechia and
Martin Lowe and
Ruggero Pardi and
Jonathon Pines The Localization of Human Cyclins B1 and
B2 Determines Cdk1 Substrate Specificity
and Neither Enzyme Requires Mek to
Disassemble the Golgi Apparatus . . . . 945
Kristen J. Verhey and
Debra Meyer and
Reneé Deehan and
John Blenis and
Bruce J. Schnapp and
Tom A. Rapoport and
Ben Margolis Cargo of Kinesin Identified as Jip
Scaffolding Proteins and Associated
Signaling Molecules . . . . . . . . . . 959
Xiu-Rong Ren and
Quan-Sheng Du and
Yang-Zhong Huang and
Shi-Zhou Ao and
Lin Mei and
Wen-Cheng Xiong Regulation of Cdc42 Gtpase by
Proline-Rich Tyrosine Kinase 2
Interacting with Psgap, a Novel
Pleckstrin Homology and Src Homology 3
Domain Containing Rhogap Protein . . . . 971
Chin-Yi Chen and
Jeanine Graham and
Hong Yan Evidence for a Replication Function of
Ffa-1, the \bionameXenopus Orthologue of
Werner Syndrome Protein . . . . . . . . 985
Shirlee Tan and
Nikunj Somia and
Pamela Maher and
David Schubert Regulation of Antioxidant Metabolism by
Translation Initiation Factor 2$ \alpha
$ . . . . . . . . . . . . . . . . . . . 997
Christos G. Zervas and
Stephen L. Gregory and
Nicholas H. Brown Drosophila Integrin--Linked Kinase Is
Required at Sites of Integrin Adhesion
to Link the Cytoskeleton to the Plasma
Membrane . . . . . . . . . . . . . . . . 1007
Ying Fu and
Guang Wu and
Zhenbiao Yang ROP Gtpase--Dependent Dynamics of
Tip--Localized F--Actin Controls Tip
Growth in Pollen Tubes . . . . . . . . . 1019
Nurul Kabir and
Andrew W. Schaefer and
Arash Nakhost and
Wayne S. Sossin and
Paul Forscher Protein Kinase C Activation Promotes
Microtubule Advance in Neuronal Growth
Cones by Increasing Average Microtubule
Growth Lifetimes . . . . . . . . . . . . 1033
Clair Baldock and
Abraham J. Koster and
Ulrike Ziese and
Matthew J. Rock and
Michael J. Sherratt and
Karl E. Kadler and
C. Adrian Shuttleworth and
Cay M. Kielty The Supramolecular Organization of
Fibrillin--Rich Microfibrils . . . . . . 1045
Albert Pol and
Robert Luetterforst and
Margaret Lindsay and
Sanna Heino and
Elina Ikonen and
Robert G. Parton A Caveolin Dominant Negative Mutant
Associates with Lipid Bodies and Induces
Intracellular Cholesterol Imbalance . . 1057
Anne G. Ostermeyer and
James M. Paci and
Youchun Zeng and
Douglas M. Lublin and
Sean Munro and
Deborah A. Brown Accumulation of Caveolin in the
Endoplasmic Reticulum Redirects the
Protein to Lipid Storage Droplets . . . 1071
Toyoshi Fujimoto and
Hiroshi Kogo and
Kimiko Ishiguro and
Kumi Tauchi and
Ryuji Nomura Caveolin-2 Is Targeted to Lipid
Droplets, a New ``Membrane Domain'' in
the Cell . . . . . . . . . . . . . . . . 1079
Maria-Antonietta Impagnatiello and
Stefan Weitzer and
Grainne Gannon and
Amelia Compagni and
Matt Cotten and
Gerhard Christofori Mammalian Sprouty-1 and -2 Are
Membrane-Anchored Phosphoprotein
Inhibitors of Growth Factor Signaling in
Endothelial Cells . . . . . . . . . . . 1087
François-Michel Boisvert and
Michael J. Kruhlak and
Alan K. Box and
Michael J. Hendzel and
David P. Bazett-Jones The Transcription Coactivator Cbp Is a
Dynamic Component of the Promyelocytic
Leukemia Nuclear Body . . . . . . . . . 1099
Carmen Cifuentes-Diaz and
Tony Frugier and
Francesco D. Tiziano and
Emmanuelle Lac\`ene and
Natacha Roblot and
Vandana Joshi and
Marie Helene Moreau and
Judith Melki Deletion of Murine SMN Exon 7 Directed
to Skeletal Muscle Leads to Severe
Muscular Dystrophy . . . . . . . . . . . 1107
Margot Thome and
Olivier Gaide and
Olivier Micheau and
Fabio Martinon and
David Bonnet and
Montserrat Gonzalez and
Jürg Tschopp Equine Herpesvirus Protein E10 Induces
Membrane Recruitment and Phosphorylation
of Its Cellular Homologue, Bcl-10 . . . 1115
Bruce R. Zetter Hold That Line . . . . . . . . . . . . . 0
Hiromi Sesaki and
Robert E. Jensen UGO1 Encodes an Outer Membrane Protein
Required for Mitochondrial Fusion . . . 1123
Matthew K. Topham and
Stephen M. Prescott Diacylglycerol Kinase $ \zeta $
Regulates Ras Activation by a Novel
Mechanism . . . . . . . . . . . . . . . 1135
Lars Kjòller and
Alan Hall Rac Mediates Cytoskeletal Rearrangements
and Increased Cell Motility Induced by
Urokinase--Type Plasminogen Activator
Receptor Binding to Vitronectin . . . . 1145
Clarissa L. Waites and
Anand Mehta and
Philip K. Tan and
Gary Thomas and
Robert H. Edwards and
David E. Krantz An Acidic Motif Retains Vesicular
Monoamine Transporter 2 on Large Dense
Core Vesicles . . . . . . . . . . . . . 1159
Josephine C. Adams and
Nina Kureishy and
Amanda L. Taylor A Role for Syndecan-1 in Coupling Fascin
Spike Formation by Thrombospondin-1 . . 1169
Atsushi Suzuki and
Tomoyuki Yamanaka and
Tomonori Hirose and
Naoyuki Manabe and
Keiko Mizuno and
Miki Shimizu and
Kazunori Akimoto and
Yasushi Izumi and
Tetsuo Ohnishi and
Shigeo Ohno Atypical Protein Kinase C Is Involved in
the Evolutionarily Conserved Par Protein
Complex and Plays a Critical Role in
Establishing Epithelia--Specific
Junctional Structures . . . . . . . . . 1183
Bernard Degryse and
Tiziana Bonaldi and
Paola Scaffidi and
Susanne Müller and
Massimo Resnati and
Francesca Sanvito and
Gianluigi Arrigoni and
Marco E. Bianchi The High Mobility Group (Hmg) Boxes of
the Nuclear Protein Hmg1 Induce
Chemotaxis and Cytoskeleton
Reorganization in Rat Smooth Muscle
Cells . . . . . . . . . . . . . . . . . 1197
Dean J. Burkin and
Gregory Q. Wallace and
Kimberly J. Nicol and
David J. Kaufman and
Stephen J. Kaufman Enhanced Expression of the $ \alpha $7$
\beta $1 Integrin Reduces Muscular
Dystrophy and Restores Viability in
Dystrophic Mice . . . . . . . . . . . . 1207
Brian D. Ackley and
Jennifer R. Crew and
Harri Elamaa and
Tania Pihlajaniemi and
Calvin J. Kuo and
James M. Kramer The Nc1/Endostatin Domain of
\bionameCaenorhabditis elegans Type
XVIII Collagen Affects Cell Migration
and Axon Guidance . . . . . . . . . . . 1219
Calvin J. Kuo and
Kenneth R. LaMontagne and
Guillermo Garcia-Cardeña and
Brian D. Ackley and
Daniel Kalman and
Susan Park and
Rolf Christofferson and
Junne Kamihara and
Yuan-Hua Ding and
Kin-Ming Lo and
Stephen Gillies and
Judah Folkman and
Richard C. Mulligan and
Kashi Javaherian Oligomerization-Dependent Regulation of
Motility and Morphogenesis by the
Collagen XVIII Nc1/Endostatin Domain . . 1233
Boris Troyanovsky and
Tetyana Levchenko and
Göran Månsson and
Olga Matvijenko and
Lars Holmgren Angiomotin . . . . . . . . . . . . . . . 1247
Chad G. Pearson and
Paul S. Maddox and
E. D. Salmon and
Kerry Bloom Budding Yeast Chromosome Structure and
Dynamics during Mitosis . . . . . . . . 1255
Laura Furstenthal and
Brett K. Kaiser and
Craig Swanson and
Peter K. Jackson Cyclin E Uses Cdc6 as a
Chromatin--Associated Receptor Required
for DNA Replication . . . . . . . . . . 1267
Yi-Tao Yu and
Mei-Di Shu and
Aarthi Narayanan and
Rebecca M. Terns and
Michael P. Terns and
Joan A. Steitz Internal Modification of U2 Small
Nuclear (Snrna) Occurs in Nucleoli of
\bionameXenopus Oocytes . . . . . . . . 1279
George Zanazzi and
Steven Einheber and
Richard Westreich and
Melanie-Jane Hannocks and
Debra Bedell-Hogan and
Mark A. Marchionni and
James L. Salzer Glial Growth Factor/Neuregulin Inhibits
Schwann Cell Myelination and Induces
Demyelination . . . . . . . . . . . . . 1289
Yuri V. Fedorov and
R. Scott Rosenthal and
Bradley B. Olwin Oncogenic Ras--Induced Proliferation
Requires Autocrine Fibroblast Growth
Factor 2 Signaling in Skeletal Muscle
Cells . . . . . . . . . . . . . . . . . 1301
John F. Reilly and
Pamela A. Maher Importin $ \beta $--Mediated Nuclear
Import of Fibroblast Growth Factor
Receptor . . . . . . . . . . . . . . . . 1307
Shoichiro Ono The \bionameCaenorhabditis elegans
unc-78 Gene Encodes a Homologue of
Actin--Interacting Protein 1 Required
for Organized Assembly of Muscle Actin
Filaments . . . . . . . . . . . . . . . 1313
Lúcia S. Borges and
Michael Ferns Agrin-Induced Phosphorylation of the
Acetylcholine Receptor Regulates
Cytoskeletal Anchoring and Clustering 1
Carlo Iomini and
Veronica Babaev-Khaimov and
Massimo Sassaroli and
Gianni Piperno Protein Particles in Chlamydomonas
Flagella Undergo a Transport Cycle
Consisting of Four Phases . . . . . . . 13
Wanjoo Chun and
Mathieu Lesort and
Janusz Tucholski and
Christopher A. Ross and
Gail V. W. Johnson Tissue Transglutaminase Does Not
Contribute to the Formation of Mutant
Huntingtin Aggregates . . . . . . . . . 25
Xiao Yang and
Lin Chen and
Xiaoling Xu and
Cuiling Li and
Cuifen Huang and
Chu-Xia Deng TGF-$ \beta $ \slash Smad3 Signals
Repress Chondrocyte Hypertrophic
Differentiation and Are Required for
Maintaining Articular Cartilage . . . . 35
Olivia W. Rossanese and
Catherine A. Reinke and
Brooke J. Bevis and
Adam T. Hammond and
Irina B. Sears and
James O'Connor and
Benjamin S. Glick A Role for Actin, Cdc1p, and Myo2p in
the Inheritance of Late Golgi Elements
in \bionameSaccharomyces cerevisiae . . 47
Carolyn D. Silflow and
Matthew LaVoie and
Lai-Wa Tam and
Susan Tousey and
Mark Sanders and
Wei-chien Wu and
Mark Borodovsky and
Paul A. Lefebvre The Vfl1 Protein in Chlamydomonas
Localizes in a Rotationally Asymmetric
Pattern at the Distal Ends of the Basal
Bodies . . . . . . . . . . . . . . . . . 63
Vitold E. Galkin and
Albina Orlova and
Natalya Lukoyanova and
Willy Wriggers and
Edward H. Egelman Actin Depolymerizing Factor Stabilizes
an Existing State of F--Actin and Can
Change the Tilt of F--Actin Subunits . . 75
Chisato Ueta and
Masahiro Iwamoto and
Naoko Kanatani and
Carolina Yoshida and
Yang Liu and
Motomi Enomoto-Iwamoto and
Tomoharu Ohmori and
Hirayuki Enomoto and
Ken Nakata and
Kenji Takada and
Kojiro Kurisu and
Toshihisa Komori Skeletal Malformations Caused by
Overexpression of Cbfa1 or Its Dominant
Negative Form in Chondrocytes . . . . . 87
Kami Ahmad and
Steven Henikoff Centromeres Are Specialized Replication
Domains in Heterochromatin . . . . . . . 101
Stanislav Vitha and
Rosemary S. McAndrew and
Katherine W. Osteryoung Ftsz Ring Formation at the Chloroplast
Division Site in Plants . . . . . . . . 111
Nicole den Elzen and
Jonathon Pines Cyclin a Is Destroyed in Prometaphase
and Can Delay Chromosome Alignment and
Anaphase . . . . . . . . . . . . . . . . 121
Stephan Geley and
Edgar Kramer and
Christian Gieffers and
Julian Gannon and
Jan-Michael Peters and
Tim Hunt Anaphase-Promoting
Complex/Cyclosome-Dependent Proteolysis
of Human Cyclin a Starts at the
Beginning of Mitosis and Is Not Subject
to the Spindle Assembly Checkpoint . . . 137
Priya Prakash Budde and
Akiko Kumagai and
William G. Dunphy and
Rebecca Heald Regulation of Op18 during Spindle
Assembly in \bionameXenopus Egg Extracts 149
Neil R. Adames and
Jessica R. Oberle and
John A. Cooper The Surveillance Mechanism of the
Spindle Position Checkpoint in Yeast . . 159
Danyang Chen and
Sui Huang Nucleolar Components Involved in
Ribosome Biogenesis Cycle between the
Nucleolus and Nucleoplasm in Interphase
Cells . . . . . . . . . . . . . . . . . 169
Laura M. Johns and
Edwin S. Levitan and
Eric A. Shelden and
Ronald W. Holz and
Daniel Axelrod Restriction of Secretory Granule Motion
near the Plasma Membrane of Chromaffin
Cells . . . . . . . . . . . . . . . . . 177
David Reczek and
Anthony Bretscher Identification of Epi64, a Tbc/Rabgap
Domain--Containing Microvillar Protein
That Binds to the First PDZ Domain of
Ebp50 and E3karp . . . . . . . . . . . . 191
Miguel Angel Sanjuán and
David R. Jones and
Manuel Izquierdo and
Isabel Mérida Role of Diacylglycerol Kinase $ \alpha $
in the Attenuation of Receptor Signaling 207
Darren L. Roberts and
Wendy Merrison and
Marion MacFarlane and
Gerald M. Cohen The Inhibitor of Apoptosis
Protein--Binding Domain of Smac Is Not
Essential for Its Proapoptotic Activity 221
Piergiorgio Percipalle and
Jian Zhao and
Brian Pope and
Alan Weeds and
Uno Lindberg and
Bertil Daneholt Actin Bound to the Heterogeneous Nuclear
Ribonucleoprotein Hrp36 Is Associated
with Balbiani Ring mRNA from the Gene to
Polysomes . . . . . . . . . . . . . . . 229
Alexey Khodjakov and
Conly L. Rieder Centrosomes Enhance the Fidelity of
Cytokinesis in Vertebrates and Are
Required for Cell Cycle Progression . . 237
T. J. Mitchison Psychosine, Cytokinesis, and Orphan
Receptors . . . . . . . . . . . . . . . 0
Peter M. Elias and
Norihisa Matsuyoshi and
Hong Wu and
Chenyan Lin and
Zhi Hong Wang and
Barbara E. Brown and
John R. Stanley Desmoglein Isoform Distribution Affects
Stratum Corneum Structure and Function 243
Nima Mosammaparast and
Kelley R. Jackson and
Yurong Guo and
Cynthia J. Brame and
Jeffrey Shabanowitz and
Donald F. Hunt and
Lucy F. Pemberton Nuclear Import of Histone H2a and H2b Is
Mediated by a Network of Karyopherins 251
Mikio Furuse and
Kyoko Furuse and
Hiroyuki Sasaki and
Shoichiro Tsukita Conversion of Zonulae Occludentes from
Tight to Leaky Strand Type by
Introducing Claudin-2 into Madin--Darby
Canine Kidney I Cells . . . . . . . . . 263
Andrew E. Aplin and
Sheryl A. Stewart and
Richard K. Assoian and
R. L. Juliano Integrin-Mediated Adhesion Regulates ERK
Nuclear Translocation and
Phosphorylation of Elk-1 . . . . . . . . 273
Steven T. Suhr and
Marie-Claude Senut and
Julian P. Whitelegge and
Kym F. Faull and
Denise B. Cuizon and
Fred H. Gage Identities of Sequestered Proteins in
Aggregates from Cells with Induced
Polyglutamine Expression . . . . . . . . 283
Seema K. Tiwari-Woodruff and
Alex G. Buznikov and
Trung Q. Vu and
Paul E. Micevych and
Kendall Chen and
Harley I. Kornblum and
Jeff M. Bronstein Osp\slash Claudin-11 Forms a Complex
with a Novel Member of the Tetraspanin
Super Family and $ \beta $1 Integrin and
Regulates Proliferation and Migration of
Oligodendrocytes . . . . . . . . . . . . 295
Roy M. Long and
Wei Gu and
Xiuhua Meng and
Graydon Gonsalvez and
Robert H. Singer and
Pascal Chartrand An Exclusively Nuclear RNA--Binding
Protein Affects Asymmetric Localization
of ASH1 mRNA and Ash1p in Yeast . . . . 307
Nigel J. Waterhouse and
Joshua C. Goldstein and
Oliver von Ahsen and
Martin Schuler and
Donald D. Newmeyer and
Douglas R. Green Cytochrome C Maintains Mitochondrial
Transmembrane Potential and ATP
Generation after Outer Mitochondrial
Membrane Permeabilization during the
Apoptotic Process . . . . . . . . . . . 319
Valerie Horsley and
Bret B. Friday and
Sarah Matteson and
Kristy Miller Kegley and
Jonathan Gephart and
Grace K. Pavlath Regulation of the Growth of
Multinucleated Muscle Cells by an
Nfatc2-Dependent Pathway . . . . . . . . 329
Sahar F. Mahmoud and
Clare Fewtrell Microdomains of High Calcium Are Not
Required for Exocytosis in Rbl-2h3
Mucosal Mast Cells . . . . . . . . . . . 339
Michael M. Kessels and
Åsa E. Y. Engqvist-Goldstein and
David G. Drubin and
Britta Qualmann Mammalian Abp1, a Signal--Responsive
F--Actin--Binding Protein, Links the
Actin Cytoskeleton to Endocytosis via
the Gtpase Dynamin . . . . . . . . . . . 351
Oliver Bischof and
Sahn-Ho Kim and
John Irving and
Sergey Beresten and
Nathan A. Ellis and
Judith Campisi Regulation and Localization of the Bloom
Syndrome Protein in Response to DNA
Damage . . . . . . . . . . . . . . . . . 367
John Kim and
Yoshiaki Kamada and
Per E. Stromhaug and
Ju Guan and
Ann Hefner-Gravink and
Misuzu Baba and
Sidney V. Scott and
Yoshinori Ohsumi and
William A. Dunn and
Daniel J. Klionsky Cvt9\slash Gsa9 Functions in
Sequestering Selective Cytosolic Cargo
Destined for the Vacuole . . . . . . . . 381
P. T. Tran and
L. Marsh and
V. Doye and
S. Inoué and
F. Chang A Mechanism for Nuclear Positioning in
Fission Yeast Based on Microtubule
Pushing . . . . . . . . . . . . . . . . 397
Marie-Louise Bang and
Ryan E. Mudry and
Abigail S. McElhinny and
Karoly Trombitás and
Adam J. Geach and
Rob Yamasaki and
Hiroyuki Sorimachi and
Henk Granzier and
Carol C. Gregorio and
Siegfried Labeit Myopalladin, a Novel 145-Kilodalton
Sarcomeric Protein with Multiple Roles
in Z--Disc and I--Band Protein
Assemblies . . . . . . . . . . . . . . . 413
Dong-Soon Im and
Christopher E. Heise and
Tuan Nguyen and
Brian F. O'Dowd and
Kevin R. Lynch Identification of a Molecular Target of
Psychosine and Its Role in Globoid Cell
Formation . . . . . . . . . . . . . . . 429
Fedor Severin and
Bianca Habermann and
Tim Huffaker and
Tony Hyman Stu2 Promotes Mitotic Spindle Elongation
in Anaphase . . . . . . . . . . . . . . 435
Anne Roush Gaillard and
Dennis R. Diener and
Joel L. Rosenbaum and
Winfield S. Sale Flagellar Radial Spoke Protein 3 Is an
a--Kinase Anchoring Protein (Akap) . . . 443
Brian Burke Lamins and Apoptosis . . . . . . . . . . 0
Colin M. Heath and
Miriam Windsor and
Thomas Wileman Aggresomes Resemble Sites Specialized
for Virus Assembly . . . . . . . . . . . 449
Jin Woo Kim and
Tong-Shin Chang and
Ji Eun Lee and
Sung-Ho Huh and
Seung Woo Yeon and
Wan Seok Yang and
Cheol O. Joe and
Inhee Mook-Jung and
Rudolph E. Tanzi and
Tae-Wan Kim and
Eui-Ju Choi Negative Regulation of the Sapk/Jnk
Signaling Pathway by Presenilin 1 . . . 457
Edith Hintermann and
Martin Bilban and
Andrew Sharabi and
Vito Quaranta Inhibitory Role of $ \alpha $6$ \beta
$4-Associated Erbb-2 and
Phosphoinositide 3-Kinase in
Keratinocyte Haptotactic Migration
Dependent on $ \alpha $3$ \beta $1
Integrin . . . . . . . . . . . . . . . . 465
Eric C. Schirmer and
Tinglu Guan and
Larry Gerace Involvement of the Lamin Rod Domain in
Heterotypic Lamin Interactions Important
for Nuclear Organization . . . . . . . . 479
Laurie Erb and
Jun Liu and
Jonathan Ockerhausen and
Qiongman Kong and
Richard C. Garrad and
Korey Griffin and
Chris Neal and
Brent Krugh and
Laura I. Santiago-Pérez and
Fernando A. González and
Hattie D. Gresham and
John T. Turner and
Gary A. Weisman An Rgd Sequence in the P2y$_2$ Receptor
Interacts with $ \alpha_V \beta_3 $
Integrins and Is Required for
G$_o$-Mediated Signal Transduction . . . 491
Kyeong Han Yoon and
Miri Yoon and
Robert D. Moir and
Satya Khuon and
Frederick W. Flitney and
Robert D. Goldman Insights into the Dynamic Properties of
Keratin Intermediate Filaments in Living
Epithelial Cells . . . . . . . . . . . . 503
Daniela Cimini and
Bonnie Howell and
Paul Maddox and
Alexey Khodjakov and
Francesca Degrassi and
E. D. Salmon Merotelic Kinetochore Orientation Is a
Major Mechanism of Aneuploidy in Mitotic
Mammalian Tissue Cells . . . . . . . . . 517
Benjamin J. Nichols and
Anne K. Kenworthy and
Roman S. Polishchuk and
Robert Lodge and
Theresa H. Roberts and
Koret Hirschberg and
Robert D. Phair and
Jennifer Lippincott-Schwartz Rapid Cycling of Lipid Raft Markers
between the Cell Surface and Golgi
Complex . . . . . . . . . . . . . . . . 529
Mats Hellström and
Holger Gerhardt and
Mattias Kalén and
Xuri Li and
Ulf Eriksson and
Hartwig Wolburg and
Christer Betsholtz Lack of Pericytes Leads to Endothelial
Hyperplasia and Abnormal Vascular
Morphogenesis . . . . . . . . . . . . . 543
Alexandra Imbert and
Rachel Eelkema and
Sara Jordan and
Helen Feiner and
Pamela Cowin $ \Delta $n89$ \beta $-Catenin Induces
Precocious Development, Differentiation,
and Neoplasia in Mammary Gland . . . . . 555
Kazuo Katoh and
Yumiko Kano and
Mutsuki Amano and
Hirofumi Onishi and
Kozo Kaibuchi and
Keigi Fujiwara Rho-Kinase--Mediated Contraction of
Isolated Stress Fibers . . . . . . . . . 569
Yizeng Tu and
Yao Huang and
Yongjun Zhang and
Yun Hua and
Chuanyue Wu A New Focal Adhesion Protein That
Interacts with Integrin--Linked Kinase
and Regulates Cell Adhesion and
Spreading . . . . . . . . . . . . . . . 585
Miho Matsuda and
Hugh F. Paterson and
Rosie Rodriguez and
Amanda C. Fensome and
Moira V. Ellis and
Karl Swann and
Matilda Katan Real Time Fluorescence Imaging of Plc$
\gamma $ Translocation and Its
Interaction with the Epidermal Growth
Factor Receptor . . . . . . . . . . . . 599
Irene Rappold and
Kuniyoshi Iwabuchi and
Takayasu Date and
Junjie Chen Tumor Suppressor P53 Binding Protein 1
(53bp1) Is Involved in DNA
Damage--Signaling Pathways . . . . . . . 613
Rikke L. Steen and
Philippe Collas Mistargeting of B--Type Lamins at the
End of Mitosis . . . . . . . . . . . . . 621
Bruce L. Goode and
Avital A. Rodal and
Georjana Barnes and
David G. Drubin Activation of the Arp2/3 Complex by the
Actin Filament Binding Protein Abp1p . . 627
Ellis Cooper A New Role for Ion Channels in Myoblast
Fusion . . . . . . . . . . . . . . . . . 0
Richard J. Maraia La Protein and the Trafficking of
Nascent RNA Polymerase III Transcripts ??
James G. Wakefield and
Silvia Bonaccorsi and
Maurizio Gatti The \bionameDrosophila Protein Asp Is
Involved in Microtubule Organization
during Spindle Formation and Cytokinesis 637
Stephen B. Helliwell and
Sascha Losko and
Chris A. Kaiser Components of a Ubiquitin Ligase Complex
Specify Polyubiquitination and
Intracellular Trafficking of the General
Amino Acid Permease . . . . . . . . . . 649
Mary M. Donaldson and
Álvaro A. M. Tavares and
Hiroyuki Ohkura and
Peter Deak and
David M. Glover Metaphase Arrest with Centromere
Separation in polo Mutants of
\bionameDrosophila . . . . . . . . . . . 663
Jacqueline Fischer-Lougheed and
Jian-Hui Liu and
Estelle Espinos and
David Mordasini and
Charles R. Bader and
Dominique Belin and
Laurent Bernheim Human Myoblast Fusion Requires
Expression of Functional Inward
Rectifier Kir2.1 Channels . . . . . . . 677
Koshiro Monzen and
Yukio Hiroi and
Sumiyo Kudoh and
Hiroshi Akazawa and
Toru Oka and
Eiki Takimoto and
Doubun Hayashi and
Toru Hosoda and
Masahiro Kawabata and
Kohei Miyazono and
Shunsuke Ishii and
Yoshio Yazaki and
Ryozo Nagai and
Issei Komuro Smads, Tak1, and Their Common Target
Atf-2 Play a Critical Role in
Cardiomyocyte Differentiation . . . . . 687
Steven O. Marx and
Steven Reiken and
Yuji Hisamatsu and
Marta Gaburjakova and
Jana Gaburjakova and
Yi-Ming Yang and
Nora Rosemblit and
Andrew R. Marks Phosphorylation-Dependent Regulation of
Ryanodine Receptors . . . . . . . . . . 699
Marcello Marelli and
C. Patrick Lusk and
Honey Chan and
John D. Aitchison and
Richard W. Wozniak A Link between the Synthesis of
Nucleoporins and the Biogenesis of the
Nuclear Envelope . . . . . . . . . . . . 709
Kawther Abu-Elneel and
Derrick R. Robinson and
Mark E. Drew and
Paul T. Englund and
Joseph Shlomai Intramitochondrial Localization of
Universal Minicircle Sequence--Binding
Protein, a Trypanosomatid Protein That
Binds Kinetoplast Minicircle Replication
Origins . . . . . . . . . . . . . . . . 725
Mark E. Drew and
Paul T. Englund Intramitochondrial Location and Dynamics
of Crithidia fasciculata Kinetoplast
Minicircle Replication Intermediates . . 735
Helge Grosshans and
Karina Deinert and
Ed Hurt and
George Simos Biogenesis of the Signal Recognition
Particle (Srp) Involves Import of Srp
Proteins into the Nucleolus, Assembly
with the Srp--RNA, and Xpo1p-Mediated
Export . . . . . . . . . . . . . . . . . 745
Elisabeth Ehler and
Robert Horowits and
Christian Zuppinger and
Robert L. Price and
Evelyne Perriard and
Martin Leu and
Pico Caroni and
Mark Sussman and
Hans M. Eppenberger and
Jean-Claude Perriard Alterations at the Intercalated Disk
Associated with the Absence of Muscle
Lim Protein . . . . . . . . . . . . . . 763
Györgyi Csankovszki and
András Nagy and
Rudolf Jaenisch Synergism of Xist RNA, DNA Methylation,
and Histone Hypoacetylation in
Maintaining X Chromosome Inactivation 773
Yohei Hirai and
Derek Radisky and
Rosanne Boudreau and
Marina Simian and
Mary E. Stevens and
Yumiko Oka and
Kyoko Takebe and
Shinichiro Niwa and
Mina J. Bissell Epimorphin Mediates Mammary Luminal
Morphogenesis through Control of C/EBP$
\beta $ . . . . . . . . . . . . . . . . 785
Satoru Funamoto and
Kristina Milan and
Ruedi Meili and
Richard A. Firtel Role of Phosphatidylinositol 3' Kinase
and a Downstream Pleckstrin Homology
Domain--Containing Protein in
Controlling Chemotaxis in
\bionameDictyostelium . . . . . . . . . 795
Xiaofeng Li and
Yali Chen and
Susanne Schéele and
Esther Arman and
Rebecca Haffner-Krausz and
Peter Ekblom and
Peter Lonai Fibroblast Growth Factor Signaling and
Basement Membrane Assembly Are Connected
during Epithelial Morphogenesis of the
Embryoid Body . . . . . . . . . . . . . 811
Reto Caldelari and
Alain de Bruin and
Dominique Baumann and
Maja M. Suter and
Christiane Bierkamp and
Vreni Balmer and
Eliane Müller A Central Role for the Armadillo Protein
Plakoglobin in the Autoimmune Disease
Pemphigus Vulgaris . . . . . . . . . . . 823
Laurent Gagnoux-Palacios and
Maryline Allegra and
Flavia Spirito and
Olivier Pommeret and
Christine Romero and
Jean-paul Ortonne and
Guerrino Meneguzzi The Short Arm of the Laminin $ \gamma $2
Chain Plays a Pivotal Role in the
Incorporation of Laminin 5 into the
Extracellular Matrix and in Cell
Adhesion . . . . . . . . . . . . . . . . 835
Anatoli B. Meriin and
Katsuhide Mabuchi and
Vladimir L. Gabai and
Julia A. Yaglom and
Alex Kazantsev and
Michael Y. Sherman Intracellular Aggregation of
Polypeptides with Expanded Polyglutamine
Domain Is Stimulated by
Stress--Activated Kinase Mekk1 . . . . . 851
Richard R. Adams and
Helder Maiato and
William C. Earnshaw and
Mar Carmena Essential Roles of \bionameDrosophila
Inner Centromere Protein (Incenp) and
Aurora B in Histone H3 Phosphorylation,
Metaphase Chromosome Alignment,
Kinetochore Disjunction, and Chromosome
Segregation . . . . . . . . . . . . . . 865
Karen A. Beningo and
Micah Dembo and
Irina Kaverina and
J. Victor Small and
Yu-li Wang Nascent Focal Adhesions Are Responsible
for the Generation of Strong Propulsive
Forces in Migrating Fibroblasts . . . . 881
Susumu Tomita and
Roger A. Nicoll and
David S. Bredt PDZ Protein Interactions Regulating
Glutamate Receptor Function and
Plasticity . . . . . . . . . . . . . . . 0
Masahiro Kajita and
Yoshifumi Itoh and
Tadashige Chiba and
Hidetoshi Mori and
Akiko Okada and
Hiroaki Kinoh and
Motoharu Seiki Membrane-Type 1 Matrix Metalloproteinase
Cleaves Cd44 and Promotes Cell Migration 893
Erkki Koivunen and
Tanja-Maria Ranta and
Arto Annila and
Seija Taube and
Asko Uppala and
Marjukka Jokinen and
Gijsbert van Willigen and
Eveliina Ihanus and
Carl G. Gahmberg Inhibition of $ \beta_2 $
Integrin-Mediated Leukocyte Cell
Adhesion by Leucine--Leucine--Glycine
Motif-Containing Peptides . . . . . . . 905
Rebecca S. Muraoka and
Anne E. G. Lenferink and
Jean Simpson and
Dana M. Brantley and
L. Renee Roebuck and
F. Michael Yakes and
Carlos L. Arteaga Cyclin-Dependent Kinase Inhibitor
P27$^{\rm Kip1}$ Is Required for Mouse
Mammary Gland Morphogenesis and Function 917
Michael Sixt and
Britta Engelhardt and
Friederike Pausch and
Rupert Hallmann and
Olaf Wendler and
Lydia M. Sorokin Endothelial Cell Laminin Isoforms,
Laminins 8 and 10, Play Decisive Roles
in T Cell Recruitment across the
Blood--Brain Barrier in Experimental
Autoimmune Encephalomyelitis . . . . . . 933
Niels Volkmann and
David DeRosier and
Paul Matsudaira and
Dorit Hanein An Atomic Model of Actin Filaments
Cross--Linked by Fimbrin and Its
Implications for Bundle Assembly and
Function . . . . . . . . . . . . . . . . 947
Mohamed Benharouga and
Martin Haardt and
Norbert Kartner and
Gergely L. Lukacs Cooh-Terminal Truncations Promote
Proteasome--Dependent Degradation of
Mature Cystic Fibrosis Transmembrane
Conductance Regulator from post-Golgi
Compartments . . . . . . . . . . . . . . 957
E. Bonnelye and
L. Merdad and
V. Kung and
J. E. Aubin The Orphan Nuclear Estrogen
Receptor--Related Receptor $ \alpha $
(Err$ \alpha $) Is Expressed Throughout
Osteoblast Differentiation and Regulates
Bone Formation in Vitro . . . . . . . . 971
Steve Palmer and
Nicola Groves and
Aaron Schindeler and
Thomas Yeoh and
Christine Biben and
Cheng-Chun Wang and
Duncan B. Sparrow and
Louise Barnett and
Nancy A. Jenkins and
Neal G. Copeland and
Frank Koentgen and
Tim Mohun and
Richard P. Harvey The Small Muscle--Specific Protein Csl
Modifies Cell Shape and Promotes Myocyte
Fusion in an Insulin-like Growth Factor
1--Dependent Manner . . . . . . . . . . 985
Lasse Foghsgaard and
Dorte Wissing and
Daniel Mauch and
Ulrik Lademann and
Lone Bastholm and
Marianne Boes and
Folmer Elling and
Marcel Leist and
Marja Jäättelä Cathepsin B Acts as a Dominant Execution
Protease in Tumor Cell Apoptosis Induced
by Tumor Necrosis Factor . . . . . . . . 999
Isabel Novoa and
Huiqing Zeng and
Heather P. Harding and
David Ron Feedback Inhibition of the Unfolded
Protein Response by GADD34-Mediated
Dephosphorylation of eIF2$ \alpha $ . . 1011
Rong Wang and
Linda D. Ferrell and
Saadia Faouzi and
Jacquelyn J. Maher and
J. Michael Bishop Activation of the Met Receptor by Cell
Attachment Induces and Sustains
Hepatocellular Carcinomas in Transgenic
Mice . . . . . . . . . . . . . . . . . . 1023
Partha Roy and
Zenon Rajfur and
David Jones and
Gerard Marriott and
Leslie Loew and
Ken Jacobson Local Photorelease of Caged Thymosin $
\beta $4 in Locomoting Keratocytes
Causes Cell Turning . . . . . . . . . . 1035
Cara J. Gottardi and
Ellen Wong and
Barry M. Gumbiner E-Cadherin Suppresses Cellular
Transformation by Inhibiting $ \beta
$-Catenin Signaling in an
Adhesion--Independent Manner . . . . . . 1049
Shuh-ichi Nishikawa and
Sheara W. Fewell and
Yoshihito Kato and
Jeffrey L. Brodsky and
Toshiya Endo Molecular Chaperones in the Yeast
Endoplasmic Reticulum Maintain the
Solubility of Proteins for
Retrotranslocation and Degradation . . . 1061
Feng-quan Zhou and
Christopher S. Cohan Growth Cone Collapse through Coincident
Loss of Actin Bundles and Leading Edge
Actin without Actin Depolymerization . . 1071
Marc Preuss and
Klaus Leonhard and
Kai Hell and
Rosemary A. Stuart and
Walter Neupert and
Johannes M. Herrmann Mba1, a Novel Component of the
Mitochondrial Protein Export Machinery
of the Yeast \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 1085
Tulia Maria Savino and
Jeannine Gébrane-Youn\`es and
Jan De Mey and
Jean-Baptiste Sibarita and
Dani\`ele Hernandez-Verdun Nucleolar Assembly of the Rrna
Processing Machinery in Living Cells . . 1097
José A. Martina and
Cecilia J. Bonangelino and
Rubén C. Aguilar and
Juan S. Bonifacino Stonin 2 . . . . . . . . . . . . . . . . 1111
Samara L. Reck-Peterson and
Matthew J. Tyska and
Peter J. Novick and
Mark S. Mooseker The Yeast Class V Myosins, Myo2p and
Myo4p, Are Nonprocessive Actin--Based
Motors . . . . . . . . . . . . . . . . . 1121
Laure Strochlic and
Annie Cartaud and
Valérie Labas and
Werner Hoch and
Jean Rossier and
Jean Cartaud Magi-1c . . . . . . . . . . . . . . . . 1127
Sergei A. Kuznetsov and
Mahesh H. Mankani and
Stan Gronthos and
Kazuhito Satomura and
Paolo Bianco and
Pamela Gehron Robey Circulating Skeletal Stem Cells . . . . 1133
J. Richard McIntosh Electron Microscopy of Cells . . . . . . 0
Abby F. Dernburg Here, There, and Everywhere . . . . . . ??
Jacob M. Jones and
James C. Morrell and
Stephen J. Gould Multiple Distinct Targeting Signals in
Integral Peroxisomal Membrane Proteins 1141
Uwe Ahting and
Michel Thieffry and
Harald Engelhardt and
Reiner Hegerl and
Walter Neupert and
Stephan Nussberger Tom40, the Pore--Forming Component of
the Protein--Conducting Tom Channel in
the Outer Membrane of Mitochondria . . . 1151
Sujata Persad and
Armelle A. Troussard and
Timothy R. McPhee and
David J. Mulholland and
Shoukat Dedhar Tumor Suppressor Pten Inhibits Nuclear
Accumulation of $ \beta $-Catenin and T
Cell/Lymphoid Enhancer Factor 1-Mediated
Transcriptional Activation . . . . . . . 1161
Daniel Riveline and
Eli Zamir and
Nathalie Q. Balaban and
Ulrich S. Schwarz and
Toshimasa Ishizaki and
Shuh Narumiya and
Zvi Kam and
Benjamin Geiger and
Alexander D. Bershadsky Focal Contacts as Mechanosensors . . . . 1175
Bao-yan Zhang and
Amy Chang and
Thomas B. Kjeldsen and
Peter Arvan Intracellular Retention of Newly
Synthesized Insulin in Yeast Is Caused
by Endoproteolytic Processing in the
Golgi Complex . . . . . . . . . . . . . 1187
Landon L. Moore and
Mark B. Roth Hcp-4, a Cenp--C-like Protein in
\bionameCaenorhabditis elegans, Is
Required for Resolution of Sister
Centromeres . . . . . . . . . . . . . . 1199
Karen Oegema and
Arshad Desai and
Sonja Rybina and
Matthew Kirkham and
Anthony A. Hyman Functional Analysis of Kinetochore
Assembly in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 1209
Mary Howe and
Kent L. McDonald and
Donna G. Albertson and
Barbara J. Meyer Him-10 Is Required for Kinetochore
Structure and Function on
\bionameCaenorhabditis elegans
Holocentric Chromosomes . . . . . . . . 1227
Hilary Sharp-Baker and
Rey-Huei Chen Spindle Checkpoint Protein Bub1 Is
Required for Kinetochore Localization of
Mad1, Mad2, Bub3, and Cenp--E,
Independently of Its Kinase Activity . . 1239
Satoshi Yamaji and
Atsushi Suzuki and
Yuki Sugiyama and
Yu-ichi Koide and
Michihiko Yoshida and
Heiwa Kanamori and
Hiroshi Mohri and
Shigeo Ohno and
Yoshiaki Ishigatsubo A Novel Integrin--Linked Kinase--Binding
Protein, Affixin, Is Involved in the
Early Stage of Cell--Substrate
Interaction . . . . . . . . . . . . . . 1251
Amotz Nechushtan and
Carolyn L. Smith and
Itschak Lamensdorf and
Soo-Han Yoon and
Richard J. Youle Bax and Bak Coalesce into Novel
Mitochondria--Associated Clusters during
Apoptosis . . . . . . . . . . . . . . . 1265
Charles J. Dimitroff and
Jack Y. Lee and
Shahin Rafii and
Robert C. Fuhlbrigge and
Robert Sackstein Cd44 Is a Major E--Selectin Ligand on
Human Hematopoietic Progenitor Cells . . 1277
Dieter R. Klopfenstein and
Judith Klumperman and
Ariel Lustig and
Richard A. Kammerer and
Viola Oorschot and
Hans-Peter Hauri Subdomain-Specific Localization of
Climp-63 (P63) in the Endoplasmic
Reticulum Is Mediated by Its Luminal $
\alpha $-Helical Segment . . . . . . . . 1287
Mounia Chami and
Devrim Gozuacik and
David Lagorce and
Marisa Brini and
Pierre Falson and
Gérard Peaucellier and
Paolo Pinton and
Hervé Lecoeur and
Marie-Lyse Gougeon and
Marc le Maire and
Rosario Rizzuto and
Christian Bréchot and
Patrizia Paterlini-Bréchot Serca1 Truncated Proteins Unable to Pump
Calcium Reduce the Endoplasmic Reticulum
Calcium Concentration and Induce
Apoptosis . . . . . . . . . . . . . . . 1301
Pinfen Yang and
Dennis R. Diener and
Joel L. Rosenbaum and
Winfield S. Sale Localization of Calmodulin and Dynein
Light Chain Lc8 in Flagellar Radial
Spokes . . . . . . . . . . . . . . . . . 1315
Vladislav V. Speransky and
Kimberly L. Taylor and
Herman K. Edskes and
Reed B. Wickner and
Alasdair C. Steven Prion Filament Networks in [Ure3] Cells
of \bionameSaccharomyces cerevisiae . . 1327
Hiroki Hagiwara and
Justin R. Fallon Shaping Membrane Architecture . . . . . 0
Hiroshi Kimura and
Peter R. Cook Kinetics of Core Histones in Living
Human Cells . . . . . . . . . . . . . . 1341
Hyukjin Cha and
Paul Shapiro Tyrosine-Phosphorylated Extracellular
Signal-Regulated Kinase Associates with
the Golgi Complex during G2/M Phase of
the Cell Cycle . . . . . . . . . . . . . 1355
John G. Marshall and
James W. Booth and
Vuk Stambolic and
Tak Mak and
Tamas Balla and
Alan D. Schreiber and
Tobias Meyer and
Sergio Grinstein Restricted Accumulation of
Phosphatidylinositol 3-Kinase Products
in a Plasmalemmal Subdomain during Fc$
\gamma $ Receptor-Mediated Phagocytosis 1369
Andrea C. Carrano and
Michele Pagano Role of the F--Box Protein Skp2 in
Adhesion--Dependent Cell Cycle
Progression . . . . . . . . . . . . . . 1381
Mark E. Lindsay and
James M. Holaska and
Katie Welch and
Bryce M. Paschal and
Ian G. Macara Ran-Binding Protein 3 Is a Cofactor for
Crm1-Mediated Nuclear Protein Export . . 1391
Shasta L. Sabo and
Annat F. Ikin and
Joseph D. Buxbaum and
Paul Greengard The Alzheimer Amyloid Precursor Protein
(APP) and Fe65, an APP--Binding Protein,
Regulate Cell Movement . . . . . . . . . 1403
Jon D. Lane and
Ma\"\ilys A. S. Vergnolle and
Philip G. Woodman and
Victoria J. Allan Apoptotic Cleavage of Cytoplasmic Dynein
Intermediate Chain and P150 $^{\rm
Glued}$ Stops Dynein--Dependent Membrane
Motility . . . . . . . . . . . . . . . . 1415
Christina M. Laukaitis and
Donna J. Webb and
Karen Donais and
Alan F. Horwitz Differential Dynamics of $ \alpha $5
Integrin, Paxillin, and $ \alpha
$-Actinin during Formation and
Disassembly of Adhesions in Migrating
Cells . . . . . . . . . . . . . . . . . 1427
Gabriela Bezakova and
Johannes P. Helm and
Maura Francolini and
Terje Lòmo Effects of Purified Recombinant Neural
and Muscle Agrin on Skeletal Muscle
Fibers in Vivo . . . . . . . . . . . . . 1441
Gabriela Bezakova and
Terje Lòmo Muscle Activity and Muscle Agrin
Regulate the Organization of
Cytoskeletal Proteins and Attached
Acetylcholine Receptor (Achr) Aggregates
in Skeletal Muscle Fibers . . . . . . . 1453
David J. Dilworth and
Adisetyantari Suprapto and
Julio C. Padovan and
Brian T. Chait and
Richard W. Wozniak and
Michael P. Rout and
John D. Aitchison Nup2p Dynamically Associates with the
Distal Regions of the Yeast Nuclear Pore
Complex . . . . . . . . . . . . . . . . 1465
Goeh Jung and
Kirsten Remmert and
Xufeng Wu and
Joanne M. Volosky and
John A. Hammer The \bionameDictyostelium Carmil Protein
Links Capping Protein and the Arp2/3
Complex to Type I Myosins through Their
Sh3 Domains . . . . . . . . . . . . . . 1479
Andrew W. Tai and
Jen-Zen Chuang and
Ching-Hwa Sung Cytoplasmic Dynein Regulation by Subunit
Heterogeneity and Its Role in Apical
Transport . . . . . . . . . . . . . . . 1499
Manuela Vecchi and
Simona Polo and
Viviane Poupon and
Jan-Willem van de Loo and
Alexandre Benmerah and
Pier Paolo Di Fiore Nucleocytoplasmic Shuttling of Endocytic
Proteins . . . . . . . . . . . . . . . . 1511
Ira Mellman Cell biology's journal gets a new look 9
Alan W. Dove Long live the pore . . . . . . . . . . . ??
Alan W. Dove Transcription in tight quarters . . . . ??
Alan W. Dove RhoA brings up the rear . . . . . . . . ??
Alan W. Dove Cataracts and NrCAM . . . . . . . . . . ??
Alan W. Dove How Toxoplasma hooks up . . . . . . . . ??
Alan W. Dove Clumping lysosomes . . . . . . . . . . . ??
William A. Wells Algal Rb sets size limits . . . . . . . ??
William A. Wells Translation in the nucleus . . . . . . . ??
William A. Wells Containing the bullet . . . . . . . . . ??
William A. Wells Taking tea with actin and microtubules ??
William A. Wells Microtubules concentrate . . . . . . . . ??
William A. Wells Death and Destruction . . . . . . . . . 14
Susan K. Lyman and
Larry Gerace Nuclear pore complexes: dynamics in
unexpected places . . . . . . . . . . . 17
Joseph W. Sanger and
Jean M. Sanger Fishing out proteins that bind to titin 21
David J. Adams and
Louise van der Weyden and
Akila Mayeda and
Stefan Stamm and
Brian J. Morris and
John E. J. Rasko ZNF265 --- a novel spliceosomal protein
able to induce alternative splicing . . 25
Waltraud G. Müller and
Dawn Walker and
Gordon L. Hager and
James G. McNally Large-scale chromatin decondensation and
recondensation regulated by
transcription from a natural promoter 33
Enrique Samper and
Fermín A. Goytisolo and
Josiane Ménissier-de Murcia and
Eva González-Suárez and
Juan C. Cigudosa and
Gilbert de Murcia and
María A. Blasco Normal telomere length and chromosomal
end capping in poly(ADP-ribose)
polymerase--deficient mice and primary
cells despite increased chromosomal
instability . . . . . . . . . . . . . . 49
Reynold I. Lopez-Soler and
Robert D. Moir and
Timothy P. Spann and
Reimer Stick and
Robert D. Goldman A role for nuclear lamins in nuclear
envelope assembly . . . . . . . . . . . 61
Nathalie Daigle and
Joël Beaudouin and
Lisa Hartnell and
Gabriela Imreh and
Einar Hallberg and
Jennifer Lippincott-Schwartz and
Jan Ellenberg Nuclear pore complexes form immobile
networks and have a very low turnover in
live mammalian cells . . . . . . . . . . 71
James N. Huang and
Iha Park and
Eric Ellingson and
Laurie E. Littlepage and
David Pellman Activity of the APC$^{\rm Cdh1}$ form of
the anaphase-promoting complex persists
until S phase and prevents the premature
expression of Cdc20p . . . . . . . . . . 85
Anthony P. Sinai and
Keith A. Joiner The Toxoplasma gondii protein ROP2
mediates host organelle association with
the parasitophorous vacuole membrane . . 95
Steve Caplan and
Lisa M. Hartnell and
Rubén C. Aguilar and
Naava Naslavsky and
Juan S. Bonifacino Human Vam6p promotes lysosome clustering
and fusion in vivo . . . . . . . . . . . 109
Paul Young and
Elisabeth Ehler and
Mathias Gautel Obscurin, a giant sarcomeric Rho guanine
nucleotide exchange factor protein
involved in sarcomere assembly . . . . . 123
Shigehiko Yumura Myosin II dynamics and cortical flow
during contractile ring formation in
\bionameDictyostelium cells . . . . . . 137
Rebecca A. Worthylake and
Sean Lemoine and
Joanna M. Watson and
Keith Burridge RhoA is required for monocyte tail
retraction during transendothelial
migration . . . . . . . . . . . . . . . 147
Kip A. West and
Huaye Zhang and
Michael C. Brown and
Sotiris N. Nikolopoulos and
M. C. Riedy and
Alan F. Horwitz and
Christopher E. Turner The LD4 motif of paxillin regulates cell
spreading and motility through an
interaction with paxillin kinase linker
(PKL) . . . . . . . . . . . . . . . . . 161
Paola A. Marignani and
Christopher L. Carpenter Vav2 is required for cell spreading . . 177
Margret I. Moré and
Frank-P. Kirsch and
Fritz G. Rathjen Targeted ablation of NrCAM or ankyrin--B
results in disorganized lens fibers
leading to cataract formation . . . . . 187
Anh-Chi N. Le and
Linda S. Musil A novel role for FGF and extracellular
signal--regulated kinase in gap
junction--mediated intercellular
communication in the lens . . . . . . . 197
X. Xu and
W. E. I. Li and
G. Y. Huang and
R. Meyer and
T. Chen and
Y. Luo and
M. P. Thomas and
G. L. Radice and
C. W. Lo Modulation of mouse neural crest cell
motility by N-cadherin and connexin 43
gap junctions . . . . . . . . . . . . . 217
Sophie Chappuis-Flament and
Ellen Wong and
Les D. Hicks and
Cyril M. Kay and
Barry M. Gumbiner Multiple cadherin extracellular repeats
mediate homophilic binding and adhesion 231
Karin Jegalian A dystroglycan ligand in the brain . . . ??
Karin Jegalian Of coilin and Cajal bodies . . . . . . . ??
Karin Jegalian Matrix patterning of digits . . . . . . ??
Karin Jegalian Tenascin turns on the EGFR . . . . . . . ??
Karin Jegalian Bringing channels into the node . . . . ??
Tabitha M. Powledge Fail-safe replication . . . . . . . . . ??
Tabitha M. Powledge Tensegrity lives . . . . . . . . . . . . ??
Tabitha M. Powledge Christmas in July . . . . . . . . . . . ??
Tabitha M. Powledge Keeping the lid on destruction . . . . . ??
Jeffrey H. Miner Mystery solved . . . . . . . . . . . . . 257
Jonathan M. Scholey and
Gregory C. Rogers and
David J. Sharp Mitosis, microtubules, and the matrix 261
Jason C. Young and
Ismail Moarefi and
F. Ulrich Hartl Hsp90 . . . . . . . . . . . . . . . . . 267
Emilio Arteaga-Solis and
Barbara Gayraud and
Sui Y. Lee and
Lillian Shum and
Lynn Sakai and
Francesco Ramirez Regulation of limb patterning by
extracellular microfibrils . . . . . . . 275
Feng Li and
Jianhua Chen and
Masako Izumi and
Mark C. Butler and
Susan M. Keezer and
David M. Gilbert The replication timing program of the
Chinese hamster $ \beta $-globin locus
is established coincident with its
repositioning near peripheral
heterochromatin in early G1 phase . . . 283
Karen E. Tucker and
Maria Teresa Berciano and
Erica Y. Jacobs and
David F. LePage and
Karl B. Shpargel and
Jennifer J. Rossire and
Edward K. L. Chan and
Miguel Lafarga and
Ronald A. Conlon and
A. Gregory Matera Residual Cajal bodies in coilin knockout
mice fail to recruit Sm snRNPs and SMN,
the spinal muscular atrophy gene product 293
Andreas Hiltbrunner and
Jörg Bauer and
Pierre-Alexandre Vidi and
Sibylle Infanger and
Petra Weibel and
Morten Hohwy and
Felix Kessler Targeting of an abundant cytosolic form
of the protein import receptor at Toc159
to the outer chloroplast membrane . . . 309
Eija Jokitalo and
Noemi Cabrera-Poch and
Graham Warren and
David T. Shima Golgi clusters and vesicles mediate
mitotic inheritance independently of the
endoplasmic reticulum . . . . . . . . . 317
Daniel Kornitzer and
Rakefet Sharf and
Tamar Kleinberger Adenovirus E4orf4 protein induces
PP2A-dependent growth arrest in
\bionameSaccharomyces cerevisiae and
interacts with the anaphase-promoting
complex/cyclosome . . . . . . . . . . . 331
Jan Grimm and
Martin Sachs and
Stefan Britsch and
Silvana Di Cesare and
Thomas Schwarz-Romond and
Kari Alitalo and
Walter Birchmeier Novel p62dok family members, dok-4 and
dok-5, are substrates of the c--Ret
receptor tyrosine kinase and mediate
neuronal differentiation . . . . . . . . 345
Kristina D. Micheva and
Ronald W. Holz and
Stephen J. Smith Regulation of presynaptic
phosphatidylinositol 4,5-biphosphate by
neuronal activity . . . . . . . . . . . 355
Héctor G. Pálmer and
José Manuel González-Sancho and
Jesús Espada and
María T. Berciano and
Isabel Puig and
Josep Baulida and
Miguel Quintanilla and
Amparo Cano and
Antonio García de Herreros and
Miguel Lafarga and
Alberto Muñoz Vitamin D$_3$ promotes the
differentiation of colon carcinoma cells
by the induction of E-cadherin and the
inhibition of $ \beta $-catenin
signaling . . . . . . . . . . . . . . . 369
Michael Hollinshead and
Gaener Rodger and
Henriette Van Eijl and
Mansun Law and
Ruth Hollinshead and
David J. T. Vaux and
Geoffrey L. Smith Vaccinia virus utilizes microtubules for
movement to the cell surface . . . . . . 389
Leexan Hong and
Tricia Elbl and
James Ward and
Clara Franzini-Armstrong and
Krystyna K. Rybicka and
Beth K. Gatewood and
David L. Baillie and
Elizabeth A. Bucher MUP-4 is a novel transmembrane protein
with functions in epithelial cell
adhesion in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 403
Mark Bercher and
Jim Wahl and
Bruce E. Vogel and
Charles Lu and
Edward M. Hedgecock and
David H. Hall and
John D. Plenefisch mua-3, a gene required for mechanical
tissue integrity in
\bionameCaenorhabditis elegans, encodes
a novel transmembrane protein of
epithelial attachment complexes . . . . 415
Charlotte F. Ratcliffe and
Ruth E. Westenbroek and
Rory Curtis and
William A. Catterall Sodium channel $ \beta $1 and $ \beta $3
subunits associate with neurofascin
through their extracellular
immunoglobulin-like domain . . . . . . . 427
Shuzo Sugita and
Fumiaki Saito and
Jiong Tang and
Jakob Satz and
Kevin Campbell and
Thomas C. Südhof A stoichiometric complex of neurexins
and dystroglycan in brain . . . . . . . 435
Ralph Brandenberger and
Andrea Schmidt and
James Linton and
Denan Wang and
Carey Backus and
Sumiko Denda and
Ullrich Müller and
Louis F. Reichardt Identification and characterization of a
novel extracellular matrix protein
nephronectin that is associated with
integrin $ \alpha $8$ \beta $1 in the
embryonic kidney . . . . . . . . . . . . 447
C. Scott Swindle and
Kien T. Tran and
Terry D. Johnson and
Pallab Banerjee and
Anne M. Mayes and
Linda Griffith and
Alan Wells Epidermal growth factor (EGF)-like
repeats of human tenascin--C as ligands
for EGF receptor . . . . . . . . . . . . 459
Alan W. Dove Putting cell polarity on the map . . . . ??
Alan W. Dove How to survive a macrophage attack . . . ??
Alan W. Dove The hidden power of platelets . . . . . ??
Alan W. Dove ARNO gets things moving . . . . . . . . ??
Alan W. Dove Deleting keratins to find one . . . . . ??
William A. Wells Sudden bacterial death syndrome . . . . ??
William A. Wells A nurse for bicoid . . . . . . . . . . . ??
William A. Wells Transcription gets a licence . . . . . . ??
William A. Wells Formin a link to microtubules . . . . . ??
William A. Wells Touching cells transform . . . . . . . . ??
William A. Wells Biotechnology on Parade . . . . . . . . 482
Stephan Lindemann and
Neal D. Tolley and
Dan A. Dixon and
Thomas M. McIntyre and
Stephen M. Prescott and
Guy A. Zimmerman and
Andrew S. Weyrich Activated platelets mediate inflammatory
signaling by regulated interleukin 1$
\beta $ synthesis . . . . . . . . . . . 485
Masahiko Itoh and
Hiroyuki Sasaki and
Mikio Furuse and
Harunobu Ozaki and
Toru Kita and
Shoichiro Tsukita Junctional adhesion molecule (JAM) binds
to PAR-3 . . . . . . . . . . . . . . . . 491
Mark R. Frey and
A. Gregory Matera RNA-mediated interaction of Cajal bodies
and U2 snRNA genes . . . . . . . . . . . 499
Fredericus J. M. van Eeden and
Isabel M. Palacios and
Mark Petronczki and
Matthew J. D. Weston and
Daniel St Johnston Barentsz is essential for the posterior
localization of oskar mRNA and
colocalizes with it to the posterior
pole . . . . . . . . . . . . . . . . . . 511
Giuliana Gatti and
Sara Trifari and
Nasrin Mesaeli and
J. M. Robert Parker and
Marek Michalak and
Jacopo Meldolesi Head-to-tail oligomerization of
calsequestrin . . . . . . . . . . . . . 525
Vishwajeet Puri and
Rikio Watanabe and
Raman Deep Singh and
Michel Dominguez and
Jennifer C. Brown and
Christine L. Wheatley and
David L. Marks and
Richard E. Pagano Clathrin-dependent and -independent
internalization of plasma membrane
sphingolipids initiates two Golgi
targeting pathways . . . . . . . . . . . 535
Becky L. Drees and
Bryan Sundin and
Elizabeth Brazeau and
Juliane P. Caviston and
Guang-Chao Chen and
Wei Guo and
Keith G. Kozminski and
Michelle W. Lau and
John J. Moskow and
Amy Tong and
Laura R. Schenkman and
Amos McKenzie and
Patrick Brennwald and
Mark Longtine and
Erfei Bi and
Clarence Chan and
Peter Novick and
Charles Boone and
John R. Pringle and
Trisha N. Davis and
Stanley Fields and
David G. Drubin A protein interaction map for cell
polarity development . . . . . . . . . . 549
Shyuichiro Matsubara and
Masayuki Ozawa Expression of $ \alpha $-catenin in $
\alpha $-catenin--deficient cells
increases resistance to
sphingosine-induced apoptosis . . . . . 573
Joaquim Egea and
Carme Espinet and
Rosa M. Soler and
Xavier Dolcet and
Víctor J. Yuste and
Mario Encinas and
Montserrat Iglesias and
Nativitat Rocamora and
Joan X. Comella Neuronal survival induced by
neurotrophins requires calmodulin . . . 585
Lorraine C. Santy and
James E. Casanova Activation of ARF6 by ARNO stimulates
epithelial cell migration through
downstream activation of both Rac1 and
phospholipase D . . . . . . . . . . . . 599
Victoria Hatch and
Gang Zhi and
Lula Smith and
James T. Stull and
Roger Craig and
William Lehman Myosin light chain kinase binding to a
unique site on F-actin revealed by
three-dimensional image reconstruction 611
Sonja M. Wojcik and
Mary A. Longley and
Dennis R. Roop Discovery of a novel murine keratin 6
(K6) isoform explains the absence of
hair and nail defects in mice deficient
for K6a and K6b . . . . . . . . . . . . 619
Rutilio A. Fratti and
Jonathan M. Backer and
Jean Gruenberg and
Silvia Corvera and
Vojo Deretic Role of phosphatidylinositol $3$-kinase
and Rab5 effectors in phagosomal
biogenesis and mycobacterial phagosome
maturation arrest . . . . . . . . . . . 631
Bridget S. Wilson and
Janet R. Pfeiffer and
Zurab Surviladze and
Elizabeth A. Gaudet and
Janet M. Oliver High resolution mapping of mast cell
membranes reveals primary and secondary
domains of Fc$ \epsilon $RI and LAT . . 645
Bill Newman and
Laure I. Gigout and
Laure Sudre and
Michael E. Grant and
Gillian A. Wallis Coordinated expression of matrix Gla
protein is required during endochondral
ossification for chondrocyte survival 659
William A. Wells Cross-linking can be good . . . . . . . ??
William A. Wells CENP-E falls off . . . . . . . . . . . . ??
William A. Wells Compartmentalized insulin signaling . . ??
William A. Wells Zones and rings in wound healing . . . . ??
William A. Wells Making virus in the axon . . . . . . . . ??
Tabitha M. Powledge Garbage in, garbage out . . . . . . . . ??
Tabitha M. Powledge Running interference . . . . . . . . . . ??
Tabitha M. Powledge Cell cycling with Rac . . . . . . . . . ??
Tabitha M. Powledge The (formerly) missing link . . . . . . ??
Tabitha M. Powledge Shedding light on protein folding . . . ??
Isabel M. Olazabal and
Laura M. Machesky Abp1p and cortactin, new ``hand-holds''
for actin . . . . . . . . . . . . . . . 679
Beth Sullivan and
Gary Karpen Centromere identity in
\bionameDrosophila is not determined in
vivo by replication timing . . . . . . . 683
Conrad L. Leung and
Min Zheng and
Susan M. Prater and
Ronald K. H. Liem The BPAG1 locus . . . . . . . . . . . . 691
Jun Xu and
Dan Liu and
Gordon Gill and
Zhou Songyang Regulation of cytokine-independent
survival kinase (CISK) by the Phox
homology domain and phosphoinositides 699
Leana M. Topper and
Holger Bastians and
Joan V. Ruderman and
Gary J. Gorbsky Elevating the level of Cdc34/Ubc3
ubiquitin-conjugating enzyme in mitosis
inhibits association of CENP-E with
kinetochores and blocks the metaphase
alignment of chromosomes . . . . . . . . 707
Kenneth Cline and
Hiroki Mori Thylakoid $ \Delta $ pH-dependent
precursor proteins bind to a
cpTatC--Hcf106 complex before
Tha4-dependent transport . . . . . . . . 719
Philippe Cupers and
Mustapha Bentahir and
Katleen Craessaerts and
Isabelle Orlans and
Hugo Vanderstichele and
Paul Saftig and
Bart De Strooper and
Wim Annaert The discrepancy between presenilin
subcellular localization and $ \gamma
$-secretase processing of amyloid
precursor protein . . . . . . . . . . . 731
M. J. Tomishima and
L. W. Enquist A conserved $ \alpha $-herpesvirus
protein necessary for axonal
localization of viral membrane proteins 741
Wilhelm Bloch and
Yun Fan and
Ji Han and
Sheng Xue and
Torsten Schöneberg and
Guanju Ji and
Zhong J. Lu and
Michael Walther and
Reinhard Fässler and
Jürgen Hescheler and
Klaus Addicks and
Bernd K. Fleischmann Disruption of cytoskeletal integrity
impairs G$_i$-mediated signaling due to
displacement of G$_i$ proteins . . . . . 753
Stéphane Gilbert and
Anne Loranger and
Nathalie Daigle and
Normand Marceau Simple epithelium keratins 8 and 18
provide resistance to Fas-mediated
apoptosis. The protection occurs through
a receptor-targeting modulation . . . . 763
Walter Witke and
Wei Li and
David J. Kwiatkowski and
Frederick S. Southwick Comparisons of CapG and gelsolin-null
macrophages . . . . . . . . . . . . . . 775
Craig A. Mandato and
William M. Bement Contraction and polymerization cooperate
to assemble and close actomyosin rings
around \bionameXenopus oocyte wounds . . 785
Liliane Michalik and
Béatrice Desvergne and
Nguan Soon Tan and
Sharmila Basu-Modak and
Pascal Escher and
Jennifer Rieusset and
Jeffrey M. Peters and
Gürkan Kaya and
Frank J. Gonzalez and
Jozsef Zakany and
Daniel Metzger and
Pierre Chambon and
Denis Duboule and
Walter Wahli Impaired skin wound healing in
peroxisome proliferator--activated
receptor (PPAR) $ \alpha $ and PPAR $
\beta $ mutant mice . . . . . . . . . . 799
Rui Lin and
Bonnie J. Warn-Cramer and
Wendy E. Kurata and
Alan F. Lau v-Src phosphorylation of connexin 43 on
Tyr247 and Tyr265 disrupts gap
junctional communication . . . . . . . . 815
Robert T. Watson and
Satoshi Shigematsu and
Shian-Huey Chiang and
Silvia Mora and
Makoto Kanzaki and
Ian G. Macara and
Alan R. Saltiel and
Jeffrey E. Pessin Lipid raft microdomain
compartmentalization of TC10 is required
for insulin signaling and GLUT4
translocation . . . . . . . . . . . . . 829
Lihsia Chen and
Bryan Ong and
Vann Bennett LAD-1, the \bionameCaenorhabditis
elegans L1CAM homologue, participates in
embryonic and gonadal morphogenesis and
is a substrate for fibroblast growth
factor receptor pathway-dependent
phosphotyrosine-based signaling . . . . 841
Nadine Jarousse and
Regis B. Kelly The AP2 binding site of synaptotagmin 1
is not an internalization signal but a
regulator of endocytosis . . . . . . . . 857
Laurie Stepanek and
Qi Lun Sun and
Jun Wang and
Cong Wang and
John L. Bixby CRYP-2\slash cPTPRO is a neurite
inhibitory repulsive guidance cue for
retinal neurons in vitro . . . . . . . . 867
William A. Edens and
Lisa Sharling and
Guangjie Cheng and
Raymond Shapira and
Joseph M. Kinkade and
Taehoon Lee and
Heather A. Edens and
Xuexin Tang and
Cameron Sullards and
Denise B. Flaherty and
Guy M. Benian and
J. David Lambeth Tyrosine cross-linking of extracellular
matrix is catalyzed by Duox, a
multidomain oxidase/peroxidase with
homology to the phagocyte oxidase
subunit gp91 phox . . . . . . . . . . . 879
Alan W. Dove Collagen reveals a hidden talent . . . . ??
Alan W. Dove The spindle assembly checkpoint gets a
complex . . . . . . . . . . . . . . . . ??
Alan W. Dove Flight of the titins . . . . . . . . . . ??
Alan W. Dove Chk1, Chk2, is the amplifier on? . . . . ??
Alan W. Dove Two new ways to eat beans . . . . . . . ??
William A. Wells All skin and brain . . . . . . . . . . . ??
William A. Wells An organelle knockout . . . . . . . . . ??
William A. Wells Squeezing in with sugar . . . . . . . . ??
William A. Wells Rafts to the front; rafts to the rear ??
William A. Wells Cohesin's cohesion . . . . . . . . . . . ??
William A. Wells Histones Rule!: The FASEB Conference on
Chromatin and Transcription. July 7--12,
2001 . . . . . . . . . . . . . . . . . . 906
M. Andrew Hoyt A new view of the spindle checkpoint . . 909
Carmen Feijoo and
Clare Hall-Jackson and
Rong Wu and
David Jenkins and
Jane Leitch and
David M. Gilbert and
Carl Smythe Activation of mammalian Chk1 during DNA
replication arrest . . . . . . . . . . . 913
Valery Sudakin and
Gordon K. T. Chan and
Tim J. Yen Checkpoint inhibition of the APC/C in
HeLa cells is mediated by a complex of
BUBR1, BUB3, CDC20, and MAD2 . . . . . . 925
Daniel Denning and
Brook Mykytka and
Nadia P. C. Allen and
Lan Huang and
Al Burlingame and
Michael Rexach The nucleoporin Nup60p functions as a
Gsp1p--GTP--sensitive tether for Nup2p
at the nuclear pore complex . . . . . . 937
Renée S. Polizotto and
Martha S. Cyert Calcineurin-dependent nuclear import of
the transcription factor Crz1p requires
Nmd5p . . . . . . . . . . . . . . . . . 951
Kimitoshi Nakamura and
Anna Zuppini and
Serge Arnaudeau and
Jeffery Lynch and
Irfan Ahsan and
Ryoko Krause and
Sylvia Papp and
Humbert De Smedt and
Jan B. Parys and
Werner Müller-Esterl and
Daniel P. Lew and
Karl-Heinz Krause and
Nicolas Demaurex and
Michal Opas and
Marek Michalak Functional specialization of
calreticulin domains . . . . . . . . . . 961
Kiminori Toyooka and
Takashi Okamoto and
Takao Minamikawa Cotyledon cells of \bionameVigna mungo
seedlings use at least two distinct
autophagic machineries for degradation
of starch granules and cellular
components . . . . . . . . . . . . . . . 973
Ethan Lee and
Adrian Salic and
Marc W. Kirschner Physiological regulation of $ \beta
$-catenin stability by Tcf3 and CK1$
\epsilon $ . . . . . . . . . . . . . . . 983
Nina Orike and
Gayle Middleton and
Emma Borthwick and
Vladimir Buchman and
Timothy Cowen and
Alun M. Davies Role of PI $3$-kinase, Akt and
Bcl-2--related proteins in sustaining
the survival of neurotrophic
factor--independent adult sympathetic
neurons . . . . . . . . . . . . . . . . 995
Fraser D. Brown and
Andrew L. Rozelle and
Helen L. Yin and
Tamás Balla and
Julie G. Donaldson Phosphatidylinositol 4,5-bisphosphate
and Arf6-regulated membrane traffic . . 1007
Joshua Sussman and
David Stokoe and
Natalya Ossina and
Emma Shtivelman Protein kinase B phosphorylates AHNAK
and regulates its subcellular
localization . . . . . . . . . . . . . . 1019
Giorgio Scita and
Pierluigi Tenca and
Liliana B. Areces and
Arianna Tocchetti and
Emanuela Frittoli and
Giuseppina Giardina and
Isabella Ponzanelli and
Patrizia Sini and
Metello Innocenti and
Pier Paolo Di Fiore An effector region in Eps8 is
responsible for the activation of the
Rac-specific GEF activity of Sos-1 and
for the proper localization of the
Rac-based actin--polymerizing machine 1031
Michael Kulke and
Ciprian Neagoe and
Bernhard Kolmerer and
Ave Minajeva and
Horst Hinssen and
Belinda Bullard and
Wolfgang A. Linke Kettin, a major source of myofibrillar
stiffness in \bionameDrosophila indirect
flight muscle . . . . . . . . . . . . . 1045
Koichi Ito and
Shinji Komazaki and
Kazushige Sasamoto and
Morikatsu Yoshida and
Miyuki Nishi and
Kenji Kitamura and
Hiroshi Takeshima Deficiency of triad junction and
contraction in mutant skeletal muscle
lacking junctophilin type 1 . . . . . . 1059
Jingsong Xu and
Dorothy Rodriguez and
Eric Petitclerc and
Jenny J. Kim and
Masanori Hangai and
S. Moon Yuen and
George E. Davis and
Peter C. Brooks Proteolytic exposure of a cryptic site
within collagen type IV is required for
angiogenesis and tumor growth in vivo 1069
Jan L. Sechler and
Hongwei Rao and
Anne Marie Cumiskey and
Irbert Vega-Colón and
Michael S. Smith and
Takatoshi Murata and
Jean E. Schwarzbauer A novel fibronectin binding site
required for fibronectin fibril growth
during matrix assembly . . . . . . . . . 1081
William A. Wells Joined at the Hip . . . . . . . . . . . ??
William A. Wells Sticky utrophin messages . . . . . . . . ??
William A. Wells Cooperation in the cerebellum . . . . . ??
William A. Wells Mitosis without wind . . . . . . . . . . ??
William A. Wells From nuclear pore to kinetochore . . . . ??
Vicki Glaser Tales from the crypt . . . . . . . . . . ??
Vicki Glaser Antagonistic drivers share BuMPy pathway ??
Vicki Glaser Arp bent out of shape . . . . . . . . . ??
Vicki Glaser Desmosomes sort it out . . . . . . . . . ??
Vicki Glaser Tagged From birth . . . . . . . . . . . ??
William A. Wells Searching for a spindle matrix . . . . . 1102
Yuko Mimori-Kiyosue and
Shoichiro Tsukita Where is APC going? . . . . . . . . . . 1105
Joan B. Mannick and
Christopher Schonhoff and
Natalia Papeta and
Pedram Ghafourifar and
Marten Szibor and
Kezhong Fang and
Benjamin Gaston S-Nitrosylation of mitochondrial
caspases . . . . . . . . . . . . . . . . 1111
Cynthia A. Earles and
Jihong Bai and
Ping Wang and
Edwin R. Chapman The tandem C2 domains of synaptotagmin
contain redundant Ca$^2$ + binding sites
that cooperate to engage t--SNAREs and
trigger exocytosis . . . . . . . . . . . 1117
Tarun M. Kapoor and
Timothy J. Mitchison Eg5 is static in bipolar spindles
relative to tubulin . . . . . . . . . . 1125
Aime A. Levesque and
Duane A. Compton The chromokinesin Kid is necessary for
chromosome arm orientation and
oscillation, but not congression, on
mitotic spindles . . . . . . . . . . . . 1135
Na\"\ima Belgareh and
Gwénaël Rabut and
Siau Wei Ba\"\i and
Megan van Overbeek and
Joël Beaudouin and
Nathalie Daigle and
Olga V. Zatsepina and
Fabien Pasteau and
Valérie Labas and
Micheline Fromont-Racine and
Jan Ellenberg and
Valérie Doye An evolutionarily conserved NPC
subcomplex, which redistributes in part
to kinetochores in mammalian cells . . . 1147
Xiangming Gao and
Tanya Chandra and
Michel-Olivier Gratton and
Isabelle Quélo and
Josée Prud'homme and
Stefano Stifani and
René St-Arnaud HES6 acts as a transcriptional repressor
in myoblasts and can induce the myogenic
differentiation program . . . . . . . . 1161
Anthony O. Gramolini and
Guy Bélanger and
Bernard J. Jasmin Distinct regions in the 3' untranslated
region are responsible for targeting and
stabilizing utrophin transcripts in
skeletal muscle cells . . . . . . . . . 1173
Andreas Stockinger and
Andreas Eger and
Julia Wolf and
Hartmut Beug and
Roland Foisner E-cadherin regulates cell growth by
modulating proliferation-dependent $
\beta $-catenin transcriptional activity 1185
Pamela L. Tuma and
Lydia K. Nyasae and
Jonathan M. Backer and
Ann L. Hubbard Vps34p differentially regulates
endocytosis from the apical and
basolateral domains in polarized hepatic
cells . . . . . . . . . . . . . . . . . 1197
Åsa E. Y. Engqvist-Goldstein and
Robin A. Warren and
Michael M. Kessels and
James H. Keen and
John Heuser and
David G. Drubin The actin-binding protein Hip1R
associates with clathrin during early
stages of endocytosis and promotes
clathrin assembly in vitro . . . . . . . 1209
Songwei Wu and
Jose Sangerman and
Ming Li and
George H. Brough and
Steven R. Goodman and
Troy Stevens Essential control of an endothelial cell
I$_{SOC}$ by the spectrin membrane
skeleton . . . . . . . . . . . . . . . . 1225
Monica Carmosino and
Giuseppe Procino and
Grazia Paola Nicchia and
Roberta Mannucci and
Jean-Marc Verbavatz and
Ren\`ee Gobin and
Maria Svelto and
Giovanna Valenti Histamine treatment induces
rearrangements of orthogonal arrays of
particles (OAPs) in human
AQP4-expressing gastric cells . . . . . 1235
Song-Kyu Park and
Robert Miller and
Ian Krane and
Timothy Vartanian The erbB2 gene is required for the
development of terminally differentiated
spinal cord oligodendrocytes . . . . . . 1245
Takeshi Sakurai and
Marc Lustig and
Joanne Babiarz and
Andrew J. W. Furley and
Steven Tait and
Peter J. Brophy and
Stephen A. Brown and
Lucia Y. Brown and
Carol A. Mason and
Martin Grumet Overlapping functions of the cell
adhesion molecules Nr--CAM and L1 in
cerebellar granule cell development . . 1259
Alan W. Dove Saying NO to muscular dystrophy . . . . ??
Alan W. Dove Muscle cells experience a nuclear
buildup . . . . . . . . . . . . . . . . ??
William A. Wells Bone breakage . . . . . . . . . . . . . ??
Alan W. Dove Apical transport gets motorized . . . . ??
Alan W. Dove Knock twice before invading . . . . . . ??
Alan W. Dove Disgorging the MVB . . . . . . . . . . . ??
William A. Wells Wingless and the argosomes . . . . . . . ??
William A. Wells Cold-induced dwarfism . . . . . . . . . ??
William A. Wells Actin's origins . . . . . . . . . . . . ??
William A. Wells Beware the Borg . . . . . . . . . . . . ??
William A. Wells Remaking the heart . . . . . . . . . . . ??
David J. Gillooly and
Anne Simonsen and
Harald Stenmark Phosphoinositides and phagocytosis . . . 15
Otilia V. Vieira and
Roberto J. Botelho and
Lucia Rameh and
Saskia M. Brachmann and
Tsuyoshi Matsuo and
Howard W. Davidson and
Alan Schreiber and
Jonathan M. Backer and
Lewis C. Cantley and
Sergio Grinstein Distinct roles of class I and class III
phosphatidylinositol $3$-kinases in
phagosome formation and maturation . . . 19
Yewei Liu and
Zoltán Cseresnyés and
William R. Randall and
Martin F. Schneider Activity-dependent nuclear translocation
and intranuclear distribution of NFATc
in adult skeletal muscle fibers . . . . 27
Kathryn J. Mitchell and
Paolo Pinton and
Aniko Varadi and
Carlo Tacchetti and
Edward K. Ainscow and
Tullio Pozzan and
Rosario Rizzuto and
Guy A. Rutter Dense core secretory vesicles revealed
as a dynamic Ca$^{2+}$ store in
neuroendocrine cells with a
vesicle-associated membrane protein
\bionameaequorin chimaera . . . . . . . 41
Monique Kleijmeer and
Georg Ramm and
Danita Schuurhuis and
Janice Griffith and
Maria Rescigno and
Paola Ricciardi-Castagnoli and
Alexander Y. Rudensky and
Ferry Ossendorp and
Cornelis J. M. Melief and
Willem Stoorvogel and
Hans J. Geuze Reorganization of multivesicular bodies
regulates MHC class II antigen
presentation by dendritic cells . . . . 53
Junlin Teng and
Yosuke Takei and
Akihiro Harada and
Takao Nakata and
Jianguo Chen and
Nobutaka Hirokawa Synergistic effects of MAP2 and MAP1B
knockout in neuronal migration,
dendritic outgrowth, and microtubule
organization . . . . . . . . . . . . . . 65
Yasuko Noda and
Yasushi Okada and
Nobuhito Saito and
Mitsutoshi Setou and
Ying Xu and
Zheizeng Zhang and
Nobutaka Hirokawa KIFC3, a microtubule minus end--directed
motor for the apical transport of
annexin XIIIb--associated
Triton-insoluble membranes . . . . . . . 77
Justin Skoble and
Victoria Auerbuch and
Erin D. Goley and
Matthew D. Welch and
Daniel A. Portnoy Pivotal role of VASP in Arp2/3
complex--mediated actin nucleation,
actin branch-formation, and
\bionameListeria monocytogenes motility 89
Hél\`ene Bierne and
Edith Gouin and
Pascal Roux and
Pico Caroni and
Helen L. Yin and
Pascale Cossart A role for cofilin and LIM kinase in
\bionameListeria-induced phagocytosis 101
Marvin E. Adams and
Heather A. Mueller and
Stanley C. Froehner In vivo requirement of the $ \alpha
$-syntrophin PDZ domain for the
sarcolemmal localization of nNOS and
aquaporin-4 . . . . . . . . . . . . . . 113
Michelle Wehling and
Melissa J. Spencer and
James G. Tidball A nitric oxide synthase transgene
ameliorates muscular dystrophy in mdx
mice . . . . . . . . . . . . . . . . . . 123
Isabelle Hoffmann and
Emmanuel Eug\`ene and
Xavier Nassif and
Pierre-Olivier Couraud and
Sandrine Bourdoulous Activation of ErbB2 receptor tyrosine
kinase supports invasion of endothelial
cells by Neisseria meningitidis . . . . 133
Oren Dwir and
Geoffrey S. Kansas and
Ronen Alon Cytoplasmic anchorage of L-selectin
controls leukocyte capture and rolling
by increasing the mechanical stability
of the selectin tether . . . . . . . . . 145
Wenguang Liu and
Satoru Toyosawa and
Tatsuya Furuichi and
Naoko Kanatani and
Carolina Yoshida and
Yang Liu and
Miki Himeno and
Satoru Narai and
Akira Yamaguchi and
Toshihisa Komori Overexpression of Cbfa1 in osteoblasts
inhibits osteoblast maturation and
causes osteopenia with multiple
fractures . . . . . . . . . . . . . . . 157
William A. Wells An extended release for surfactant . . . ??
William A. Wells Virus one; laminin nil . . . . . . . . . ??
William A. Wells Bind and bend . . . . . . . . . . . . . ??
William A. Wells p115 untethered . . . . . . . . . . . . ??
William A. Wells Exchanging clathrin . . . . . . . . . . ??
Mitch Leslie Stayin' alive, without antigen . . . . . ??
Mitch Leslie A mobile transcription factor . . . . . ??
Mitch Leslie Sizing up cell division . . . . . . . . ??
Mitch Leslie Leaf starter . . . . . . . . . . . . . . ??
Mitch Leslie Death by mistake . . . . . . . . . . . . ??
Tom Misteli The concept of self-organization in
cellular architecture . . . . . . . . . 181
Andrew E. Aplin and
R. L. Juliano Regulation of nucleocytoplasmic
trafficking by cell adhesion receptors
and the cytoskeleton . . . . . . . . . . 187
Khashayar Farsad and
Niels Ringstad and
Kohji Takei and
Scott R. Floyd and
Kristin Rose and
Pietro De Camilli Generation of high curvature membranes
mediated by direct endophilin bilayer
interactions . . . . . . . . . . . . . . 193
Kai Schuh and
Stjepan Uldrijan and
Myriam Telkamp and
Nicola Röthlein and
Ludwig Neyses The plasmamembrane calmodulin-dependent
calcium pump . . . . . . . . . . . . . . 201
Andre Fortin and
Sean P. Cregan and
Jason G. MacLaurin and
Neena Kushwaha and
Emma S. Hickman and
Charlie S. Thompson and
Antoine Hakim and
Paul R. Albert and
Francesco Cecconi and
Kristian Helin and
David S. Park and
Ruth S. Slack APAF1 is a key transcriptional target
for p53 in the regulation of neuronal
cell death . . . . . . . . . . . . . . . 207
Janice Robertson and
Jean-Martin Beaulieu and
Mohammad M. Doroudchi and
Heather D. Durham and
Jean-Pierre Julien and
Walter E. Mushynski Apoptotic death of neurons exhibiting
peripherin aggregates is mediated by the
proinflammatory cytokine tumor necrosis
factor-$ \alpha $ . . . . . . . . . . . 217
Manojkumar A. Puthenveedu and
Adam D. Linstedt Evidence that Golgi structure depends on
a p115 activity that is independent of
the vesicle tether components giantin
and GM130 . . . . . . . . . . . . . . . 227
Maren Heese and
Xavier Gansel and
Liliane Sticher and
Peter Wick and
Markus Grebe and
Fabienne Granier and
Gerd Jürgens Functional characterization of the
KNOLLE-interacting t--SNARE AtSNAP33 and
its role in plant cytokinesis . . . . . 239
Sandra Palmgren and
Pauli J. Ojala and
Martin A. Wear and
John A. Cooper and
Pekka Lappalainen Interactions with PIP$_2$, ADP-actin
monomers, and capping protein regulate
the activity and localization of yeast
twinfilin . . . . . . . . . . . . . . . 251
Terry Lechler and
Gudrun A. Jonsdottir and
Saskia K. Klee and
David Pellman and
Rong Li A two-tiered mechanism by which Cdc42
controls the localization and activation
of an Arp2/3-activating motor complex in
yeast . . . . . . . . . . . . . . . . . 261
Florian Mullershausen and
Michael Russwurm and
W. Joseph Thompson and
Li Liu and
Doris Koesling and
Andreas Friebe Rapid nitric oxide--induced
desensitization of the cGMP response is
caused by increased activity of
phosphodiesterase type 5 paralleled by
phosphorylation of the enzyme . . . . . 271
Thomas Haller and
Paul Dietl and
Kristian Pfaller and
Manfred Frick and
Norbert Mair and
Markus Paulmichl and
Michael W. Hess and
Johannes Fürst and
Karl Maly Fusion pore expansion is a slow,
discontinuous, and Ca$^{2+}$-dependent
process regulating secretion from
alveolar type II cells . . . . . . . . . 279
Xufeng Wu and
Xiaohong Zhao and
Lauren Baylor and
Shivani Kaushal and
Evan Eisenberg and
Lois E. Greene Clathrin exchange during
clathrin-mediated endocytosis . . . . . 291
Stefan Kunz and
Noemí Sevilla and
Dorian B. McGavern and
Kevin P. Campbell and
Michael B. A. Oldstone Molecular analysis of the interaction of
LCMV with its cellular receptor $ \alpha
$-dystroglycan . . . . . . . . . . . . . 301
Alan W. Dove Potential muscles everywhere . . . . . . ??
Alan W. Dove Shape up or ship out . . . . . . . . . . ??
Alan W. Dove How big is your organelle? . . . . . . . ??
Alan W. Dove Death by unligated integrin . . . . . . ??
Alan W. Dove The growth cone gets a grip . . . . . . ??
William A. Wells Old cells gone bad . . . . . . . . . . . ??
William A. Wells Sustained specificity . . . . . . . . . ??
William A. Wells Swimming with sperm . . . . . . . . . . ??
William A. Wells Arms together, CENs apart . . . . . . . ??
William A. Wells Killing for love . . . . . . . . . . . . ??
Daniel G. Jay A Src-astic response to mounting tension 327
Martin Villalba and
Kun Bi and
Fernando Rodriguez and
Yoshihiko Tanaka and
Stephen Schoenberger and
Amnon Altman Vav1\slash Rac-dependent actin
cytoskeleton reorganization is required
for lipid raft clustering in T cells . . 331
Sanjay Vasu and
Sundeep Shah and
Arturo Orjalo and
Minkyu Park and
Wolfgang H. Fischer and
Douglass J. Forbes Novel vertebrate nucleoporins Nup133 and
Nup160 play a role in mRNA export . . . 339
Shilpa Vashist and
Woong Kim and
William J. Belden and
Eric D. Spear and
Charles Barlowe and
Davis T. W. Ng Distinct retrieval and retention
mechanisms are required for the quality
control of endoplasmic reticulum protein
folding . . . . . . . . . . . . . . . . 355
Hein Sprong and
Sophie Degroote and
Tijs Claessens and
Judith van Drunen and
Viola Oorschot and
Ben H. C. Westerink and
Yoshio Hirabayashi and
Judith Klumperman and
Peter van der Sluijs and
Gerrit van Meer Glycosphingolipids are required for
sorting melanosomal proteins in the
Golgi complex . . . . . . . . . . . . . 369
Jacquelyn Gerhart and
Brian Bast and
Christine Neely and
Stephanie Iem and
Paula Amegbe and
Robert Niewenhuis and
Steven Miklasz and
Pei Feng Cheng and
Mindy George-Weinstein MyoD-positive myoblasts are present in
mature fetal organs lacking skeletal
muscle . . . . . . . . . . . . . . . . . 381
Astrid Weins and
Karin Schwarz and
Christian Faul and
Laura Barisoni and
Wolfgang A. Linke and
Peter Mundel Differentiation- and stress-dependent
nuclear cytoplasmic redistribution of
myopodin, a novel actin-bundling protein 393
Wallace F. Marshall and
Joel L. Rosenbaum Intraflagellar transport balances
continuous turnover of outer doublet
microtubules . . . . . . . . . . . . . . 405
Hiroyasu Inada and
Ichiro Izawa and
Miwako Nishizawa and
Eriko Fujita and
Tohru Kiyono and
Toshitada Takahashi and
Takashi Momoi and
Masaki Inagaki Keratin attenuates tumor necrosis
factor--induced cytotoxicity through
association with TRADD . . . . . . . . . 415
Daniel M. Suter and
Paul Forscher Transmission of growth cone traction
force through apCAM--cytoskeletal
linkages is regulated by Src family
tyrosine kinase activity . . . . . . . . 427
Wenbo Xu and
Michael Shy and
John Kamholz and
Lisa Elferink and
Gang Xu and
Jack Lilien and
Janne Balsamo Mutations in the cytoplasmic domain of
P0 reveal a role for PKC-mediated
phosphorylation in adhesion and
myelination . . . . . . . . . . . . . . 439
Agnese Mariotti and
Paul A. Kedeshian and
Michael Dans and
Anna Maria Curatola and
Laurent Gagnoux-Palacios and
Filippo G. Giancotti EGF-R signaling through Fyn kinase
disrupts the function of integrin $
\alpha $6$ \beta $4 at hemidesmosomes 447
Dwayne G. Stupack and
Xose S. Puente and
Souphaphone Boutsaboualoy and
Chris M. Storgard and
David A. Cheresh Apoptosis of adherent cells by
recruitment of caspase-8 to unligated
integrins . . . . . . . . . . . . . . . 459
Victoria L. Seewaldt and
Krzysztof Mrózek and
Randy Sigle and
Eric C. Dietze and
Kevin Heine and
David M. Hockenbery and
Katherine B. Hobbs and
L. Elizabeth Caldwell Suppression of p53 function in normal
human mammary epithelial cells increases
sensitivity to extracellular
matrix--induced apoptosis . . . . . . . 471
William A. Wells Cleaving and migrating . . . . . . . . . ??
William A. Wells Battle of the actin junctions . . . . . ??
William A. Wells Toxic apoptosis . . . . . . . . . . . . ??
William A. Wells Myosin V . . . . . . . . . . . . . . . . ??
William A. Wells A marker for munching . . . . . . . . . ??
Mitch Leslie A fatal break up . . . . . . . . . . . . ??
Mitch Leslie In the nick of time . . . . . . . . . . ??
Mitch Leslie Staying connected . . . . . . . . . . . ??
Mitch Leslie To branch or not to branch . . . . . . . ??
Mitch Leslie Slide this way . . . . . . . . . . . . . ??
William A. Wells Let's make Golgi . . . . . . . . . . . . 498
Selin Somersan and
Nina Bhardwaj Tethering and tickling . . . . . . . . . 501
Chuanyue Wu and
Shoukat Dedhar Integrin-linked kinase (ILK) and its
interactors . . . . . . . . . . . . . . 505
Lisa A. Flanagan and
Janet Chou and
Hervé Falet and
Ralph Neujahr and
John H. Hartwig and
Thomas P. Stossel Filamin A, the Arp2/3 complex, and the
morphology and function of cortical
actin filaments in human melanoma cells 511
Christopher L. Pin and
J. Michael Rukstalis and
Charis Johnson and
Stephen F. Konieczny The bHLH transcription factor Mist1 is
required to maintain exocrine pancreas
cell organization and acinar cell
identity . . . . . . . . . . . . . . . . 519
Keiko Miyoshi and
Jonathan M. Shillingford and
Gilbert H. Smith and
Sandra L. Grimm and
Kay-Uwe Wagner and
Takami Oka and
Jeffrey M. Rosen and
Gertraud W. Robinson and
Lothar Hennighausen Signal transducer and activator of
transcription (Stat) 5 controls the
proliferation and differentiation of
mammary alveolar epithelium . . . . . . 531
Suzanne Miles and
Heather McManus and
Kimberly E. Forsten and
Brian Storrie Evidence that the entire Golgi apparatus
cycles in interphase HeLa cells . . . . 543
Theresa H. Ward and
Roman S. Polishchuk and
Steve Caplan and
Koret Hirschberg and
Jennifer Lippincott-Schwartz Maintenance of Golgi structure and
function depends on the integrity of ER
export . . . . . . . . . . . . . . . . . 557
Keisuke Tateishi and
Masao Omata and
Keiji Tanaka and
Tomoki Chiba The NEDD8 system is essential for cell
cycle progression and morphogenetic
pathway in mice . . . . . . . . . . . . 571
Joan E. Adamo and
John J. Moskow and
Amy S. Gladfelter and
Domenic Viterbo and
Daniel J. Lew and
Patrick J. Brennwald Yeast Cdc42 functions at a late step in
exocytosis, specifically during
polarized growth of the emerging bud . . 581
Charles Yeaman and
Kent K. Grindstaff and
Jessica R. Wright and
W. James Nelson Sec6\slash 8 complexes on trans-Golgi
network and plasma membrane regulate
late stages of exocytosis in mammalian
cells . . . . . . . . . . . . . . . . . 593
Qiang Zhou and
Po-Hsien Chu and
Chenqun Huang and
Ching-Feng Cheng and
Maryann E. Martone and
Gudrun Knoll and
G. Diane Shelton and
Sylvia Evans and
Ju Chen Ablation of Cypher, a PDZ--LIM domain
Z-line protein, causes a severe form of
congenital myopathy . . . . . . . . . . 605
Frédéric Delbac and
Astrid Sänger and
Eva M. Neuhaus and
Rolf Stratmann and
James W. Ajioka and
Catherine Toursel and
Angelika Herm-Götz and
Stanislas Tomavo and
Thierry Soldati and
Dominique Soldati Toxoplasma gondii myosins B/C . . . . . 613
Jeffrey R. Moore and
Elena B. Krementsova and
Kathleen M. Trybus and
David M. Warshaw Myosin V exhibits a high duty cycle and
large unitary displacement . . . . . . . 625
Heike Bantel and
Bhanu Sinha and
Wolfram Domschke and
Georg Peters and
Klaus Schulze-Osthoff and
Reiner U. Jänicke $ \alpha $-Toxin is a mediator of
Staphylococcus aureus --induced cell
death and activates caspases via the
intrinsic death pathway independently of
death receptor signaling . . . . . . . . 637
Peter R. Hoffmann and
Aimee M. deCathelineau and
Carol Anne Ogden and
Yann Leverrier and
Donna L. Bratton and
David L. Daleke and
Anne J. Ridley and
Valerie A. Fadok and
Peter M. Henson Phosphatidylserine (PS) induces PS
receptor--mediated macropinocytosis and
promotes clearance of apoptotic cells 649
Sabine Mechtersheimer and
Paul Gutwein and
Nancy Agmon-Levin and
Alexander Stoeck and
Matthias Oleszewski and
Svenja Riedle and
Rolf Postina and
Falk Fahrenholz and
Mina Fogel and
Vance Lemmon and
Peter Altevogt Ectodomain shedding of L1 adhesion
molecule promotes cell migration by
autocrine binding to integrins . . . . . 661
Alan W. Dove Ready \ldots set \ldots fuse . . . . . . ??
Alan W. Dove Ankyrin recruits a fleet . . . . . . . . ??
Alan W. Dove Heparan sulfate gets specific . . . . . ??
Alan W. Dove The leg bone's connected to the \ldots
cerebellum? . . . . . . . . . . . . . . ??
Alan W. Dove Another Notch in CD44 . . . . . . . . . ??
William A. Wells Vpr makes holes . . . . . . . . . . . . ??
William A. Wells A TORrific ATP sensor . . . . . . . . . ??
William A. Wells Pinning down NuMA . . . . . . . . . . . ??
William A. Wells Sigma separation . . . . . . . . . . . . ??
William A. Wells Surviving in low oxygen . . . . . . . . ??
Alexei Degterev and
Michael Boyce and
Junying Yuan The channel of death . . . . . . . . . . 695
Konstantinos Meletis and
Jonas Frisén Have the bloody cells gone to our heads? 699
Peter G. Gillespie and
Joseph P. Albanesi and
Martin Bähler and
William M. Bement and
Jonathan S. Berg and
David R. Burgess and
Beth Burnside and
Richard E. Cheney and
David P. Corey and
Evelyne Coudrier and
Primal de Lanerolle and
John A. Hammer and
Tama Hasson and
Jeffrey R. Holt and
A. J. Hudspeth and
Mitsuo Ikebe and
John Kendrick-Jones and
Edward D. Korn and
Rong Li and
John A. Mercer and
Ronald A. Milligan and
Mark S. Mooseker and
E. Michael Ostap and
Christine Petit and
Thomas D. Pollard and
James R. Sellers and
Thierry Soldati and
Margaret A. Titus Myosin-I nomenclature . . . . . . . . . 703
Arcady Mushegian and
Ruslan Medzhitov Evolutionary perspective on innate
immune recognition . . . . . . . . . . . 705
Fedor Severin and
Anthony A. Hyman and
Simonetta Piatti Correct spindle elongation at the
metaphase/anaphase transition is an
APC-dependent event in budding yeast . . 711
Berna S. Sayan and
Gulayse Ince and
A. Emre Sayan and
Mehmet Ozturk NAPO as a novel marker for apoptosis . . 719
Evgeny V. Pavlov and
Muriel Priault and
Dawn Pietkiewicz and
Emily H.-Y. Cheng and
Bruno Antonsson and
Stephen Manon and
Stanley J. Korsmeyer and
Carmen A. Mannella and
Kathleen W. Kinnally A novel, high conductance channel of
mitochondria linked to apoptosis in
mammalian cells and Bax expression in
yeast . . . . . . . . . . . . . . . . . 725
Josef Priller and
Derek A. Persons and
Francisco F. Klett and
Gerd Kempermann and
Georg W. Kreutzberg and
Ulrich Dirnagl Neogenesis of cerebellar Purkinje
neurons from gene-marked bone marrow
cells in vivo . . . . . . . . . . . . . 733
Scott M. Jenkins and
Vann Bennett Ankyrin-G coordinates assembly of the
spectrin-based membrane skeleton,
voltage-gated sodium channels, and L1
CAMs at Purkinje neuron initial segments 739
Olivier Bousquet and
Linglei Ma and
Soichiro Yamada and
Changhong Gu and
Toshihiro Idei and
Kenzo Takahashi and
Denis Wirtz and
Pierre A. Coulombe The nonhelical tail domain of keratin 14
promotes filament bundling and enhances
the mechanical properties of keratin
intermediate filaments in vitro . . . . 747
Isamu Okamoto and
Yoshiaki Kawano and
Daizo Murakami and
Takashi Sasayama and
Norie Araki and
Toru Miki and
Albert J. Wong and
Hideyuki Saya Proteolytic release of CD44
intracellular domain and its role in the
CD44 signaling pathway . . . . . . . . . 755
Jung-seog Kang and
Iain M. Cheeseman and
George Kallstrom and
Soundarapandian Velmurugan and
Georjana Barnes and
Clarence S. M. Chan Functional cooperation of Dam1, Ipl1,
and the inner centromere protein
(INCENP)--related protein Sli15 during
chromosome segregation . . . . . . . . . 763
Stefan Hüttelmaier and
Susanne Illenberger and
Irina Grosheva and
Manfred Rüdiger and
Robert H. Singer and
Brigitte M. Jockusch Raver1, a dual compartment protein, is a
ligand for PTB/hnRNPI and microfilament
attachment proteins . . . . . . . . . . 775
Gudrun Wahlström and
Maria Vartiainen and
Lumi Yamamoto and
Pieta K. Mattila and
Pekka Lappalainen and
Tapio I. Heino Twinfilin is required for
actin-dependent developmental processes
in \bionameDrosophila . . . . . . . . . 787
Hiroyuki Tachikawa and
Andrew Bloecher and
Kelly Tatchell and
Aaron M. Neiman A Gip1p--Glc7p phosphatase complex
regulates septin organization and spore
wall formation . . . . . . . . . . . . . 797
Shinichiro Taya and
Naoyuki Inagaki and
Hiroaki Sengiku and
Hiroshi Makino and
Akihiro Iwamatsu and
Itaru Urakawa and
Kenji Nagao and
Shiro Kataoka and
Kozo Kaibuchi Direct interaction of insulin-like
growth factor-1 receptor with
leukemia-associated RhoGEF . . . . . . . 809
Martyn Chidgey and
Cord Brakebusch and
Erika Gustafsson and
Alan Cruchley and
Chris Hail and
Sarah Kirk and
Anita Merritt and
Alison North and
Chris Tselepis and
Jane Hewitt and
Carolyn Byrne and
Reinhard Fassler and
David Garrod Mice lacking desmocollin 1 show
epidermal fragility accompanied by
barrier defects and abnormal
differentiation . . . . . . . . . . . . 821
Ingrid Markovic and
Eugenia Leikina and
Mikhail Zhukovsky and
Joshua Zimmerberg and
Leonid V. Chernomordik Synchronized activation and refolding of
influenza hemagglutinin in multimeric
fusion machines . . . . . . . . . . . . 833
Benjamin L. Allen and
Mark S. Filla and
Alan C. Rapraeger Role of heparan sulfate as a
tissue-specific regulator of FGF-4 and
FGF receptor recognition . . . . . . . . 845
William A. Wells Tmod points the way . . . . . . . . . . ??
William A. Wells Peroxisomes on the move . . . . . . . . ??
William A. Wells Chopping and storing in one . . . . . . ??
William A. Wells Calcium-coated chromosomes . . . . . . . ??
William A. Wells An unfolding breast cancer story . . . . ??
Mitch Leslie Freed by light . . . . . . . . . . . . . ??
Mitch Leslie Going separate ways . . . . . . . . . . ??
Mitch Leslie Growing together . . . . . . . . . . . . ??
Mitch Leslie A lupus explanation . . . . . . . . . . ??
Mitch Leslie Kiss of death . . . . . . . . . . . . . ??
Suzanne R. Pfeffer Constructing a Golgi complex . . . . . . 873
Benjamin Short and
Christian Preisinger and
Roman Körner and
Robert Kopajtich and
Olwyn Byron and
Francis A. Barr A GRASP55-rab2 effector complex linking
Golgi structure to membrane traffic . . 877
Francis A. Barr and
Christian Preisinger and
Robert Kopajtich and
Roman Körner Golgi matrix proteins interact with p24
cargo receptors and aid their efficient
retention in the Golgi apparatus . . . . 885
Rachelle Franzen and
Sandra L. Tanner and
Suzanne M. Dashiell and
Catherine A. Rottkamp and
Jeffrey A. Hammer and
Richard H. Quarles Microtubule-associated protein 1B . . . 893
Reiner Strick and
Pamela L. Strissel and
Konstantin Gavrilov and
Riccardo Levi-Setti Cation--chromatin binding as shown by
ion microscopy is essential for the
structural integrity of chromosomes . . 899
Qinong Ye and
Yan-Fen Hu and
Hongjun Zhong and
Anne C. Nye and
Andrew S. Belmont and
Rong Li BRCA1-induced large-scale chromatin
unfolding and allele-specific effects of
cancer-predisposing mutations . . . . . 911
Pierre-Emmanuel Gleizes and
Jacqueline Noaillac-Depeyre and
Isabelle Léger-Silvestre and
Frédéric Teuli\`eres and
Jean-Yves Dauxois and
Denys Pommet and
Marie-Claude Azum-Gelade and
Nicole Gas Ultrastructural localization of rRNA
shows defective nuclear export of
preribosomes in mutants of the Nup82p
complex . . . . . . . . . . . . . . . . 923
Mingdong Huang and
Jacques T. Weissman and
Sophie Béraud-Dufour and
Peng Luan and
Chenqian Wang and
Wei Chen and
Meir Aridor and
Ian A. Wilson and
William E. Balch Crystal structure of Sar1-GDP at 1.7 Å
resolution and the role of the NH$_2$
terminus in ER export . . . . . . . . . 937
Kouichi Funato and
Howard Riezman Vesicular and nonvesicular transport of
ceramide from ER to the Golgi apparatus
in yeast . . . . . . . . . . . . . . . . 949
Fabienne Paumet and
Britta Brügger and
Francesco Parlati and
James A. McNew and
Thomas H. Söllner and
James E. Rothman A t--SNARE of the endocytic pathway must
be activated for fusion . . . . . . . . 961
Jason H. Brickner and
Jennifer M. Blanchette and
György Sipos and
Robert S. Fuller The Tlg SNARE complex is required for
TGN homotypic fusion . . . . . . . . . . 969
Dominic Hoepfner and
Marlene van den Berg and
Peter Philippsen and
Henk F. Tabak and
Ewald H. Hettema A role for Vps1p, actin, and the Myo2p
motor in peroxisome abundance and
inheritance in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 979
Liwen Jiang and
Thomas E. Phillips and
Christopher A. Hamm and
Yolanda M. Drozdowicz and
Philip A. Rea and
Masayoshi Maeshima and
Sally W. Rogers and
John C. Rogers The protein storage vacuole . . . . . . 991
Muniswamy Madesh and
György Hajnóczky VDAC-dependent permeabilization of the
outer mitochondrial membrane by
superoxide induces rapid and massive
cytochrome c release . . . . . . . . . . 1003
Aki Hanyu and
Yasuhiro Ishidou and
Takanori Ebisawa and
Tomomasa Shimanuki and
Takeshi Imamura and
Kohei Miyazono The N domain of Smad7 is essential for
specific inhibition of transforming
growth factor-$ \beta $ signaling . . . 1017
Julien Cau and
Sandrine Faure and
Michel Comps and
Claude Delsert and
Nathalie Morin A novel p21-activated kinase binds the
actin and microtubule networks and
induces microtubule stabilization . . . 1029
Michelle Mardahl-Dumesnil and
Velia M. Fowler Thin filaments elongate from their
pointed ends during myofibril assembly
in \bionameDrosophila indirect flight
muscle . . . . . . . . . . . . . . . . . 1043
Wei Hsu and
Reena Shakya and
Frank Costantini Impaired mammary gland and lymphoid
development caused by inducible
expression of Axin in transgenic mice 1055
Jennifer M. Dyson and
Cindy J. O'Malley and
Jelena Becanovic and
Adam D. Munday and
Michael C. Berndt and
Imogen D. Coghill and
Harshal H. Nandurkar and
Lisa M. Ooms and
Christina A. Mitchell The SH2-containing inositol
polyphosphate $5$-phosphatase, SHIP-2,
binds filamin and regulates
submembraneous actin . . . . . . . . . . 1065
Alan W. Dove A PHD in T cell evasion . . . . . . . . ??
Alan W. Dove Motoring through the checkpoint . . . . ??
Alan W. Dove Turning back an invasion . . . . . . . . ??
Alan W. Dove Finding Rho attractive . . . . . . . . . ??
Alan W. Dove Self-stimulation feels different . . . . ??
William A. Wells Dead cells get the squeeze . . . . . . . ??
William A. Wells Enter the virus . . . . . . . . . . . . ??
William A. Wells Repair long and prosper . . . . . . . . ??
William A. Wells Romeo and Leishmania . . . . . . . . . . ??
William A. Wells Making room for new memories . . . . . . ??
William A. Wells Connect the Nerves . . . . . . . . . . . 1096
Hugh R. B. Pelham Traffic through the Golgi apparatus . . 1099
Martin E. Hemler Specific tetraspanin functions . . . . . 1103
Eva Hannak and
Matthew Kirkham and
Anthony A. Hyman and
Karen Oegema Aurora-A kinase is required for
centrosome maturation in
\bionameCaenorhabditis elegans . . . . . 1109
Greg J. Bashaw and
Hailan Hu and
Catherine D. Nobes and
Corey S. Goodman A novel Dbl family RhoGEF promotes
Rho-dependent axon attraction to the
central nervous system midline in
\bionameDrosophila and overcomes Robo
repulsion . . . . . . . . . . . . . . . 1117
Gargi Maheshwari and
H. Steven Wiley and
Douglas A. Lauffenburger Autocrine epidermal growth factor
signaling stimulates directionally
persistent mammary epithelial cell
migration . . . . . . . . . . . . . . . 1123
Larissa Kotelevets and
Jolanda van Hengel and
Erik Bruyneel and
Marc Mareel and
Frans van Roy and
Eric Chastre The lipid phosphatase activity of PTEN
is critical for stabilizing
intercellular junctions and reverting
invasiveness . . . . . . . . . . . . . . 1129
Iain M. Cheeseman and
Christine Brew and
Michael Wolyniak and
Arshad Desai and
Scott Anderson and
Nemone Muster and
John R. Yates and
Tim C. Huffaker and
David G. Drubin and
Georjana Barnes Implication of a novel multiprotein
Dam1p complex in outer kinetochore
function . . . . . . . . . . . . . . . . 1137
Samantha G. Zeitlin and
Richard D. Shelby and
Kevin F. Sullivan CENP-A is phosphorylated by Aurora B
kinase and plays an unexpected role in
completion of cytokinesis . . . . . . . 1147
B. J. Howell and
B. F. McEwen and
J. C. Canman and
D. B. Hoffman and
E. M. Farrar and
C. L. Rieder and
E. D. Salmon Cytoplasmic dynein/dynactin drives
kinetochore protein transport to the
spindle poles and has a role in mitotic
spindle checkpoint inactivation . . . . 1159
Haijiang Lin and
Pedro de Carvalho and
David Kho and
Chin-Yin Tai and
Philippe Pierre and
Gerald R. Fink and
David Pellman Polyploids require Bik1 for
kinetochore--microtubule attachment . . 1173
Elizabeth E. Grevengoed and
Joseph J. Loureiro and
Traci L. Jesse and
Mark Peifer Abelson kinase regulates epithelial
morphogenesis in \bionameDrosophila . . 1185
Joel Lanoix and
Joke Ouwendijk and
Annika Stark and
Edith Szafer and
Dan Cassel and
Kurt Dejgaard and
Matthias Weiss and
Tommy Nilsson Sorting of Golgi resident proteins into
different subpopulations of COPI
vesicles . . . . . . . . . . . . . . . . 1199
José A. Martínez-Menárguez and
Rytis Prekeris and
Viola M. J. Oorschot and
Richard Scheller and
Jan W. Slot and
Hans J. Geuze and
Judith Klumperman Peri-Golgi vesicles contain retrograde
but not anterograde proteins consistent
with the cisternal progression model of
intra-Golgi transport . . . . . . . . . 1213
Alexander A. Mironov and
Galina V. Beznoussenko and
Paolo Nicoziani and
Oliviano Martella and
Alvar Trucco and
Hee-Seok Kweon and
Daniele Di Giandomenico and
Roman S. Polishchuk and
Aurora Fusella and
Pietro Lupetti and
Eric G. Berger and
Willie J. C. Geerts and
Abraham J. Koster and
Koert N. J. Burger and
Alberto Luini Small cargo proteins and large
aggregates can traverse the Golgi by a
common mechanism without leaving the
lumen of cisternae . . . . . . . . . . . 1225
Pak Phi Poon and
Steven F. Nothwehr and
Richard A. Singer and
Gerald C. Johnston The Gcs1 and Age2 ArfGAP proteins
provide overlapping essential function
for transport from the yeast trans-Golgi
network . . . . . . . . . . . . . . . . 1239
C. E. Futter and
L. M. Collinson and
J. M. Backer and
C. R. Hopkins Human VPS34 is required for internal
vesicle formation within multivesicular
endosomes . . . . . . . . . . . . . . . 1251
Laurent Coscoy and
David Jesse Sanchez and
Don Ganem A novel class of herpesvirus-encoded
membrane-bound E3 ubiquitin ligases
regulates endocytosis of proteins
involved in immune recognition . . . . . 1265
Marta Majdan and
Gregory S. Walsh and
Raquel Aloyz and
Freda D. Miller TrkA mediates developmental sympathetic
neuron survival in vivo by silencing an
ongoing p75NTR-mediated death signal . . 1275
Andreas Sander and
Boris A. Hesser and
Veit Witzemann MuSK induces in vivo acetylcholine
receptor clusters in a
ligand-independent manner . . . . . . . 1287
Kazuki Horikawa and
Masatoshi Takeichi Requirement of the juxtamembrane domain
of the cadherin cytoplasmic tail for
morphogenetic cell rearrangement during
myotome development . . . . . . . . . . 1297
Erica M. TenBroek and
Paul D. Lampe and
Joell L. Solan and
James K. Reynhout and
Ross G. Johnson Ser364 of connexin43 and the
upregulation of gap junction assembly by
cAMP . . . . . . . . . . . . . . . . . . 1307
Christoph Ballestrem and
Boris Hinz and
Beat A. Imhof and
Bernhard Wehrle-Haller Marching at the front and dragging
behind . . . . . . . . . . . . . . . . . 1319
Maria J. G. Jiménez and
Milagros Balbín and
Jesús Alvarez and
Toshihisa Komori and
Paolo Bianco and
Kenn Holmbeck and
Henning Birkedal-Hansen and
José M. López and
Carlos López-Otín A regulatory cascade involving retinoic
acid, Cbfa1, and matrix
metalloproteinases is coupled to the
development of a process of
perichondrial invasion and osteogenic
differentiation during bone formation 1333
Takamasa Uekita and
Yoshifumi Itoh and
Ikuo Yana and
Hiroshi Ohno and
Motoharu Seiki Cytoplasmic tail-dependent
internalization of membrane-type 1
matrix metalloproteinase is important
for its invasion-promoting activity . . 1345
William A. Wells Sticking together a signal . . . . . . . ??
William A. Wells Let's make liver . . . . . . . . . . . . ??
William A. Wells Polo meets the APC . . . . . . . . . . . ??
William A. Wells To Rb or not to Rb . . . . . . . . . . . ??
William A. Wells Squeezing for healing . . . . . . . . . ??
Mitch Leslie Greater risk from radiation? . . . . . . ??
Mitch Leslie Numbers game . . . . . . . . . . . . . . ??
Mitch Leslie Grow-your-own synapses . . . . . . . . . ??
Mitch Leslie The good side of a maligned protein . . ??
Mitch Leslie Waltz of the chromosomes . . . . . . . . ??
Steven S. Scherer Myelination . . . . . . . . . . . . . . 13
Helge Grosshans and
Frank J. Slack Micro-RNAs . . . . . . . . . . . . . . . 17
Karen M. May and
Nicola Reynolds and
C. Fiona Cullen and
Mitsuhiro Yanagida and
Hiroyuki Ohkura Polo boxes and Cut23 (Apc8) mediate an
interaction between polo kinase and the
anaphase-promoting complex for fission
yeast mitosis . . . . . . . . . . . . . 23
Valérie Denis and
Martha S. Cyert Internal Ca$^{2+}$ release in yeast is
triggered by hypertonic shock and
mediated by a TRP channel homologue . . 29
Daniel H. Schott and
Ruth N. Collins and
Anthony Bretscher Secretory vesicle transport velocity in
living cells depends on the myosin--V
lever arm length . . . . . . . . . . . . 35
Wei Gu and
Feng Pan and
Honglai Zhang and
Gary J. Bassell and
Robert H. Singer A predominantly nuclear protein
affecting cytoplasmic localization of $
\beta $-actin mRNA in fibroblasts and
neurons . . . . . . . . . . . . . . . . 41
Amy M. Brownawell and
Ian G. Macara Exportin-5, a novel karyopherin,
mediates nuclear export of
double-stranded RNA binding proteins . . 53
Angelika Hausser and
Gisela Link and
Linda Bamberg and
Annett Burzlaff and
Sylke Lutz and
Klaus Pfizenmaier and
Franz-Josef Johannes Structural requirements for localization
and activation of protein kinase C $ \mu
$ (PKC$ \mu $) at the Golgi compartment 65
Khaled Machaca and
Shirley Haun Induction of maturation-promoting factor
during \bionameXenopus oocyte maturation
uncouples Ca$^{2+}$ store depletion from
store-operated Ca$^{2+}$ entry . . . . . 75
Toshiro Ohta and
Russell Essner and
Jung-Hwa Ryu and
Robert E. Palazzo and
Yumi Uetake and
Ryoko Kuriyama Characterization of Cep135, a novel
coiled-coil centrosomal protein involved
in microtubule organization in mammalian
cells . . . . . . . . . . . . . . . . . 87
Kyoungtae Kim and
Thomas C. S. Keller Smitin, a novel smooth muscle titin-like
protein, interacts with myosin filaments
in vivo and in vitro . . . . . . . . . . 101
Arthur S. Rovner and
Patricia M. Fagnant and
Susan Lowey and
Kathleen M. Trybus The carboxyl-terminal isoforms of smooth
muscle myosin heavy chain determine
thick filament assembly properties . . . 113
Metello Innocenti and
Pierluigi Tenca and
Emanuela Frittoli and
Mario Faretta and
Arianna Tocchetti and
Pier Paolo Di Fiore and
Giorgio Scita Mechanisms through which Sos-1
coordinates the activation of Ras and
Rac . . . . . . . . . . . . . . . . . . 125
Enzo Calautti and
Maddalena Grossi and
Cristina Mammucari and
Yumi Aoyama and
Maria Pirro and
Yoshitaka Ono and
Jie Li and
G. Paolo Dotto Fyn tyrosine kinase is a downstream
mediator of Rho/PRK2 function in
keratinocyte cell--cell adhesion . . . . 137
Taro Matsumoto and
Ingela Turesson and
Majlis Book and
Pär Gerwins and
Lena Claesson-Welsh p38 MAP kinase negatively regulates
endothelial cell survival,
proliferation, and differentiation in
FGF-2--stimulated angiogenesis . . . . . 149
Jo Ellen Feugate and
QiJing Li and
Lina Wong and
Manuela Martins-Green The cxc chemokine cCAF stimulates
differentiation of fibroblasts into
myofibroblasts and accelerates wound
closure . . . . . . . . . . . . . . . . 161
Atsushi Suzuki and
Yun-wen Zheng and
Shin Kaneko and
Masafumi Onodera and
Katashi Fukao and
Hiromitsu Nakauchi and
Hideki Taniguchi Clonal identification and
characterization of self-renewing
pluripotent stem cells in the developing
liver . . . . . . . . . . . . . . . . . 173
Zhe Jiang and
Eldad Zacksenhaus Activation of retinoblastoma protein in
mammary gland leads to ductal growth
suppression, precocious differentiation,
and adenocarcinoma . . . . . . . . . . . 185
M. Laura Feltri and
Diana Graus Porta and
Stefano C. Previtali and
Alessandro Nodari and
Barbara Migliavacca and
Arianna Cassetti and
Amanda Littlewood-Evans and
Louis F. Reichardt and
Albee Messing and
Angelo Quattrini and
Ulrich Mueller and
Lawrence Wrabetz Conditional disruption of $ \beta $1
integrin in Schwann cells impedes
interactions with axons . . . . . . . . 199
Alan W. Dove It's a chaperone \ldots it's a
gatekeeper \ldots it's BiP . . . . . . . ??
Alan W. Dove Sorting out secretion . . . . . . . . . ??
Alan W. Dove Finding degradation at the checkpoint ??
Alan W. Dove Survival gets more complicated . . . . . ??
Alan W. Dove A GTPase that goes both ways . . . . . . ??
Rabiya Tuma and
William A. Wells Cells and More Cells . . . . . . . . . . 220
Branka Dabovic and
Yan Chen and
Cristina Colarossi and
Hiroto Obata and
Laura Zambuto and
Mary Ann Perle and
Daniel B. Rifkin Bone abnormalities in latent TGF-$ \beta
$ binding protein (Ltbp)-3--null mice
indicate a role for Ltbp-3 in modulating
TGF-$ \beta $ bioavailability . . . . . 227
Giovanna Lalli and
Giampietro Schiavo Analysis of retrograde transport in
motor neurons reveals common endocytic
carriers for tetanus toxin and
neurotrophin receptor p75$^{\rm NTR}$ 233
Amy K. A. deHart and
Joshua D. Schnell and
Damian A. Allen and
Linda Hicke The conserved Pkh--Ypk kinase cascade is
required for endocytosis in yeast . . . 241
Dongmin Kang and
James Chen and
Jim Wong and
Guowei Fang The checkpoint protein Chfr is a ligase
that ubiquitinates Plk1 and inhibits
Cdc2 at the G2 to M transition . . . . . 249
Nora G. Haigh and
Arthur E. Johnson A new role for BiP . . . . . . . . . . . 261
Edina Harsay and
Randy Schekman A subset of yeast vacuolar protein
sorting mutants is blocked in one branch
of the exocytic pathway . . . . . . . . 271
Ulrich Schweizer and
Jennifer Gunnersen and
Christoph Karch and
Stefan Wiese and
Bettina Holtmann and
Kiyoshi Takeda and
Shizuo Akira and
Michael Sendtner Conditional gene ablation of Stat3
reveals differential signaling
requirements for survival of motoneurons
during development and after nerve
injury in the adult . . . . . . . . . . 287
Elzbieta Janda and
Kerstin Lehmann and
Iris Killisch and
Martin Jechlinger and
Michaela Herzig and
Julian Downward and
Hartmut Beug and
Stefan Grünert Ras and TGF$ \beta $ cooperatively
regulate epithelial cell plasticity and
metastasis . . . . . . . . . . . . . . . 299
Amy S. Gladfelter and
Indrani Bose and
Trevin R. Zyla and
Elaine S. G. Bardes and
Daniel J. Lew Septin ring assembly involves cycles of
GTP loading and hydrolysis by Cdc42p . . 315
Andrew A. Peden and
Rachel E. Rudge and
Winnie W. Y. Lui and
Margaret S. Robinson Assembly and function of AP-3 complexes
in cells expressing mutant subunits . . 327
Masayuki Komada and
Philippe Soriano $ \beta $IV-spectrin regulates sodium
channel clustering through ankyrin--G at
axon initial segments and nodes of
Ranvier . . . . . . . . . . . . . . . . 337
Olga Krylyshkina and
Irina Kaverina and
Wolfgang Kranewitter and
Walter Steffen and
Maria C. Alonso and
Robert A. Cross and
J. Victor Small Modulation of substrate adhesion
dynamics via microtubule targeting
requires kinesin-1 . . . . . . . . . . . 349
Arjan van der Flier and
Ingrid Kuikman and
Duco Kramer and
Dirk Geerts and
Maaike Kreft and
Toshiro Takafuta and
Sandor S. Shapiro and
Arnoud Sonnenberg Different splice variants of filamin--B
affect myogenesis, subcellular
distribution, and determine binding to
integrin $ \beta $ subunits . . . . . . 361
Simona Degani and
Fiorella Balzac and
Mara Brancaccio and
Simona Guazzone and
Saverio Francesco Retta and
Lorenzo Silengo and
Alessandra Eva and
Guido Tarone The integrin cytoplasmic
domain-associated protein ICAP-1 binds
and regulates Rho family GTPases during
cell spreading . . . . . . . . . . . . . 377
Carien M. Niessen and
Barry M. Gumbiner Cadherin-mediated cell sorting not
determined by binding or adhesion
specificity . . . . . . . . . . . . . . 389
William A. Wells Monitoring MLCK . . . . . . . . . . . . ??
William A. Wells Visualizing vesicles . . . . . . . . . . ??
William A. Wells With A$ \beta $, the danger lies within ??
William A. Wells GRASP65 gets the chop . . . . . . . . . ??
William A. Wells Building a spindle pole . . . . . . . . ??
William A. Wells Cloning confusion . . . . . . . . . . . ??
William A. Wells What makes Ran run? . . . . . . . . . . ??
William A. Wells A JAK/STAT invasion . . . . . . . . . . ??
William A. Wells The Hippi did it . . . . . . . . . . . . ??
William A. Wells Crossed TRAILs . . . . . . . . . . . . . ??
Suresh Subramani Hitchhiking fads en route to peroxisomes 415
David E. Anderson and
Ana Losada and
Harold P. Erickson and
Tatsuya Hirano Condensin and cohesin display different
arm conformations with characteristic
hinge angles . . . . . . . . . . . . . . 419
Paula Sacco-Bubulya and
David L. Spector Disassembly of interchromatin granule
clusters alters the coordination of
transcription and pre-mRNA splicing . . 425
Régis Giet and
Doris McLean and
Simon Descamps and
Michael J. Lee and
Jordan W. Raff and
Claude Prigent and
David M. Glover Drosophila Aurora A kinase is required
to localize D--TACC to centrosomes and
to regulate astral microtubules . . . . 437
Andrea R. Castillo and
Janet B. Meehl and
Garry Morgan and
Amy Schutz-Geschwender and
Mark Winey The yeast protein kinase Mps1p is
required for assembly of the integral
spindle pole body component Spc42p . . . 453
Jochen Huber and
Achim Dickmanns and
Reinhard Lührmann The importin-$ \beta $ binding domain of
snurportin1 is responsible for the Ran-
and energy-independent nuclear import of
spliceosomal U snRNPs in vitro . . . . . 467
Vladimir I. Titorenko and
Jean-Marc Nicaud and
Huijie Wang and
Honey Chan and
Richard A. Rachubinski Acyl-CoA oxidase is imported as a
heteropentameric, cofactor-containing
complex into peroxisomes of Yarrowia
lipolytica . . . . . . . . . . . . . . . 481
Jon D. Lane and
John Lucocq and
James Pryde and
Francis A. Barr and
Philip G. Woodman and
Victoria J. Allan and
Martin Lowe Caspase-mediated cleavage of the
stacking protein GRASP65 is required for
Golgi fragmentation during apoptosis . . 495
Pierre Barbero and
Lenka Bittova and
Suzanne R. Pfeffer Visualization of Rab9-mediated vesicle
transport from endosomes to the
trans-Golgi in living cells . . . . . . 511
Yan Zhang and
Richard McLaughlin and
Cynthia Goodyer and
Andréa LeBlanc Selective cytotoxicity of intracellular
amyloid $ \beta $ peptide$_{1 - - 42}$
through p53 and Bax in cultured primary
human neurons . . . . . . . . . . . . . 519
Pascale F. Dijkers and
Kim U. Birkenkamp and
Eric W.-F. Lam and
N. Shaun B. Thomas and
Jan-Willem J. Lammers and
Leo Koenderman and
Paul J. Coffer FKHR-L1 can act as a critical effector
of cell death induced by cytokine
withdrawal . . . . . . . . . . . . . . . 531
Teng-Leong Chew and
Wendy A. Wolf and
Patricia J. Gallagher and
Fumio Matsumura and
Rex L. Chisholm A fluorescent resonant energy
transfer--based biosensor reveals
transient and regional myosin light
chain kinase activation in lamella and
cleavage furrows . . . . . . . . . . . . 543
Akira Mizoguchi and
Hiroyuki Nakanishi and
Kazushi Kimura and
Kaho Matsubara and
Kumi Ozaki-Kuroda and
Tatsuo Katata and
Tomoyuki Honda and
Yoshimoto Kiyohara and
Kyun Heo and
Mikito Higashi and
Tomonari Tsutsumi and
Satomi Sonoda and
Chizuka Ide and
Yoshimi Takai Nectin . . . . . . . . . . . . . . . . . 555
Jill Marcus and
Jeffrey L. Dupree and
Brian Popko Myelin-associated glycoprotein and
myelin galactolipids stabilize
developing axo-glial interactions . . . 567
Alan W. Dove The sound of one foot walking . . . . . ??
Alan W. Dove Activating actin . . . . . . . . . . . . ??
Alan W. Dove Do cells have mouths? . . . . . . . . . ??
Alan W. Dove If you stretch it, they will come . . . ??
Alan W. Dove Meanwhile, back at the ring canal \ldots ??
Nicole LeBrasseur Sex, Sox, and splicing . . . . . . . . . ??
Nicole LeBrasseur Structural Mad-ness . . . . . . . . . . ??
Nicole LeBrasseur Keeping the cord in place . . . . . . . ??
Nicole LeBrasseur Swallowing pain relief . . . . . . . . . ??
Nicole LeBrasseur Collagen melt-down . . . . . . . . . . . ??
Kathryn G. Miller Extending the Arp2/3 complex and its
regulation beyond the leading edge . . . 591
Jomon Joseph and
Shyh-Han Tan and
Tatiana S. Karpova and
James G. McNally and
Mary Dasso SUMO-1 targets RanGAP1 to kinetochores
and mitotic spindles . . . . . . . . . . 595
Timothy P. Spann and
Anne E. Goldman and
Chen Wang and
Sui Huang and
Robert D. Goldman Alteration of nuclear lamin organization
inhibits RNA polymerase II-dependent
transcription . . . . . . . . . . . . . 603
Yasuhiro Sawada and
Michael P. Sheetz Force transduction by Triton
cytoskeletons . . . . . . . . . . . . . 609
Phyllis Frosst and
Tinglu Guan and
Cecilia Subauste and
Klaus Hahn and
Larry Gerace Tpr is localized within the nuclear
basket of the pore complex and has a
role in nuclear protein export . . . . . 617
Franck Perez and
Karin Pernet-Gallay and
Clément Nizak and
Holly V. Goodson and
Thomas E. Kreis and
Bruno Goud CLIPR-59, a new trans-Golgi/TGN
cytoplasmic linker protein belonging to
the CLIP-170 family . . . . . . . . . . 631
Xiaoling Li and
Stephen J. Gould PEX11 promotes peroxisome division
independently of peroxisome metabolism 643
Frédéric Mallard and
Bor Luen Tang and
Thierry Galli and
Dani\`ele Tenza and
Agn\`es Saint-Pol and
Xu Yue and
Claude Antony and
Wanjin Hong and
Bruno Goud and
Ludger Johannes Early\slash recycling endosomes--to--TGN
transport involves two SNARE complexes
and a Rab6 isoform . . . . . . . . . . . 653
Francesca Santini and
Ibragim Gaidarov and
James H. Keen G protein--coupled receptor/arrestin3
modulation of the endocytic machinery 665
Andrew M. Hudson and
Lynn Cooley A subset of dynamic actin rearrangements
in \bionameDrosophila requires the
Arp2/3 complex . . . . . . . . . . . . . 677
Jennifer A. Zallen and
Yehudit Cohen and
Andrew M. Hudson and
Lynn Cooley and
Eric Wieschaus and
Eyal D. Schejter SCAR is a primary regulator of
Arp2/$3$-dependent morphological events
in \bionameDrosophila . . . . . . . . . 689
Reed J. Kelso and
Andrew M. Hudson and
Lynn Cooley Drosophila Kelch regulates actin
organization via Src64-dependent
tyrosine phosphorylation . . . . . . . . 703
Steven P. Gross and
Michael A. Welte and
Steven M. Block and
Eric F. Wieschaus Coordination of opposite-polarity
microtubule motors . . . . . . . . . . . 715
Samuel Y. Cho and
Richard L. Klemke Purification of pseudopodia from
polarized cells reveals redistribution
and activation of Rac through assembly
of a CAS/Crk scaffold . . . . . . . . . 725
Gerhard Schratt and
Ulrike Philippar and
Jürgen Berger and
Heinz Schwarz and
Olaf Heidenreich and
Alfred Nordheim Serum response factor is crucial for
actin cytoskeletal organization and
focal adhesion assembly in embryonic
stem cells . . . . . . . . . . . . . . . 737
Angelika C. Paul and
Nadia Rosenthal Different modes of hypertrophy in
skeletal muscle fibers . . . . . . . . . 751
Nicole LeBrasseur The bud is all in the timing . . . . . . ??
Nicole LeBrasseur Shocking localization . . . . . . . . . ??
Nicole LeBrasseur Actin to completion . . . . . . . . . . ??
Nicole LeBrasseur A kinase kick for endocytosis . . . . . ??
Nicole LeBrasseur Enabling actin . . . . . . . . . . . . . ??
William A. Wells One brain fits all . . . . . . . . . . . ??
William A. Wells Getting biorientated . . . . . . . . . . ??
William A. Wells Systemic destruction . . . . . . . . . . ??
William A. Wells Cristae in crisis . . . . . . . . . . . ??
William A. Wells Put that hunchback over here . . . . . . ??
Valerie Horsley and
Grace K. Pavlath Nfat . . . . . . . . . . . . . . . . . . 771
Caroline Jolly and
Lara Konecny and
Deborah L. Grady and
Yulia A. Kutskova and
José J. Cotto and
Richard I. Morimoto and
Claire Vourc'h In vivo binding of active heat shock
transcription factor 1 to human
chromosome 9 heterochromatin during
stress . . . . . . . . . . . . . . . . . 775
Ryoko Kuriyama and
Charles Gustus and
Yasuhiko Terada and
Yumi Uetake and
Jurgita Matuliene CHO1, a mammalian kinesin-like protein,
interacts with F-actin and is involved
in the terminal phase of cytokinesis . . 783
Doris Ricotta and
Sean D. Conner and
Sandra L. Schmid and
Kurt von Figura and
Stefan Höning Phosphorylation of the AP2 $ \mu $
subunit by AAK1 mediates high affinity
binding to membrane protein sorting
signals . . . . . . . . . . . . . . . . 791
David Sheff and
Laurence Pelletier and
Christopher B. O'Connell and
Graham Warren and
Ira Mellman Transferrin receptor recycling in the
absence of perinuclear recycling
endosomes . . . . . . . . . . . . . . . 797
Brigitte D. Lavoie and
Eileen Hogan and
Douglas Koshland In vivo dissection of the chromosome
condensation machinery . . . . . . . . . 805
Anne Brunet and
Fumihiko Kanai and
Justine Stehn and
Jian Xu and
Dilara Sarbassova and
John V. Frangioni and
Sorab N. Dalal and
James A. DeCaprio and
Michael E. Greenberg and
Michael B. Yaffe 14-3-3 transits to the nucleus and
participates in dynamic
nucleocytoplasmic transport . . . . . . 817
Laura R. Schenkman and
Carlo Caruso and
Nicolas Pagé and
John R. Pringle The role of cell cycle--regulated
expression in the localization of
spatial landmark proteins in yeast . . . 829
Karianne E. Longva and
Fròydis D. Blystad and
Espen Stang and
Astrid M. Larsen and
Lene E. Johannessen and
Inger H. Madshus Ubiquitination and proteasomal activity
is required for transport of the EGF
receptor to inner membranes of
multivesicular bodies . . . . . . . . . 843
Steven P. Gross and
M. Carolina Tuma and
Sean W. Deacon and
Anna S. Serpinskaya and
Amy R. Reilein and
Vladimir I. Gelfand Interactions and regulation of molecular
motors in \bionameXenopus melanophores 855
Nathan R. Hutchings and
John E. Donelson and
Kent L. Hill Trypanin is a cytoskeletal linker
protein and is required for cell
motility in African trypanosomes . . . . 867
Pamela J. Woodring and
E. David Litwack and
Dennis D. M. O'Leary and
Ginger R. Lucero and
Jean Y. J. Wang and
Tony Hunter Modulation of the F-actin cytoskeleton
by c--Abl tyrosine kinase in cell
spreading and neurite extension . . . . 879
Safedin Beqaj and
Sandhya Jakkaraju and
Raymond R. Mattingly and
Desi Pan and
Lucia Schuger High RhoA activity maintains the
undifferentiated mesenchymal cell
phenotype, whereas RhoA down-regulation
by laminin-2 induces smooth muscle
myogenesis . . . . . . . . . . . . . . . 893
Julian C. Braz and
Orlando F. Bueno and
Leon J. De Windt and
Jeffery D. Molkentin PKC$ \alpha $ regulates the hypertrophic
growth of cardiomyocytes through
extracellular signal-regulated kinase1/2
(ERK1/2) . . . . . . . . . . . . . . . . 905
Sean D. Conner and
Sandra L. Schmid Identification of an adaptor-associated
kinase, AAK1, as a regulator of
clathrin-mediated endocytosis . . . . . 921
Alan W. Dove Tubulin but not microtubule . . . . . . ??
Alan W. Dove Finding the dark side of tau . . . . . . ??
Alan W. Dove Only one way to skin a mouse . . . . . . ??
Alan W. Dove Tropomyosin keeps actin tough . . . . . ??
Alan W. Dove An acid invasion . . . . . . . . . . . . ??
Nicole LeBrasseur Anticancer lubrication . . . . . . . . . ??
Nicole LeBrasseur Coming undone at the seams . . . . . . . ??
Nicole LeBrasseur A trip to the ER . . . . . . . . . . . . ??
Nicole LeBrasseur Crumbs turns the corner . . . . . . . . ??
Nicole LeBrasseur A dual purpose antideath agent . . . . . ??
Shaynoor Dramsi and
Pascale Cossart Listeriolysin O . . . . . . . . . . . . 943
Gianfranco Bazzoni and
Elisabetta Dejana Keratinocyte junctions and the epidermal
barrier . . . . . . . . . . . . . . . . 947
Shaun W. Lee and
Robert A. Bonnah and
Dustin L. Higashi and
John P. Atkinson and
Sharon L. Milgram and
Magdalene So CD46 is phosphorylated at tyrosine 354
upon infection of epithelial cells by
Neisseria gonorrhoeae . . . . . . . . . 951
Chin-Yin Tai and
Denis L. Dujardin and
Nicole E. Faulkner and
Richard B. Vallee Role of dynein, dynactin, and CLIP-170
interactions in LIS1 kinetochore
function . . . . . . . . . . . . . . . . 959
Valentina Sirri and
Dani\`ele Hernandez-Verdun and
Pascal Roussel Cyclin-dependent kinases govern
formation and maintenance of the
nucleolus . . . . . . . . . . . . . . . 969
Hiromichi Wada and
Koji Hasegawa and
Tatsuya Morimoto and
Tsuyoshi Kakita and
Tetsuhiko Yanazume and
Mitsuru Abe and
Shigetake Sasayama Calcineurin-GATA-6 pathway is involved
in smooth muscle-specific transcription 983
Maureen Hyde and
Laura Block-Alper and
Jahaira Felix and
Paul Webster and
David I. Meyer Induction of secretory pathway
components in yeast is associated with
increased stability of their mRNA . . . 993
C. Stewart Gillmor and
Patricia Poindexter and
Justin Lorieau and
Monica M. Palcic and
Chris Somerville $ \alpha $-Glucosidase I is required for
cellulose biosynthesis and morphogenesis
in Arabidopsis . . . . . . . . . . . . . 1003
Cecilia J. Bonangelino and
Johnathan J. Nau and
Jason E. Duex and
Mikala Brinkman and
Andrew E. Wurmser and
Jonathan D. Gary and
Scott D. Emr and
Lois S. Weisman Osmotic stress--induced increase of
phosphatidylinositol 3,5-bisphosphate
requires Vac14p, an activator of the
lipid kinase Fab1p . . . . . . . . . . . 1015
Ian J. Glomski and
Margaret M. Gedde and
Albert W. Tsang and
Joel A. Swanson and
Daniel A. Portnoy The \bionameListeria monocytogenes
hemolysin has an acidic pH optimum to
compartmentalize activity and prevent
damage to infected host cells . . . . . 1029
Ke Hu and
David S. Roos and
John M. Murray A novel polymer of tubulin forms the
conoid of Toxoplasma gondii . . . . . . 1039
K. Stamer and
R. Vogel and
E. Thies and
E. Mandelkow and
E.-M. Mandelkow Tau blocks traffic of organelles,
neurofilaments, and APP vesicles in
neurons and enhances oxidative stress 1051
Shoichiro Ono and
Kanako Ono Tropomyosin inhibits
ADF/cofilin-dependent actin filament
dynamics . . . . . . . . . . . . . . . . 1065
Katja C. Zimmermann and
Jean-Ehrland Ricci and
Nathalie M. Droin and
Douglas R. Green The role of ARK in stress-induced
apoptosis in \bionameDrosophila cells 1077
Loretta Dorstyn and
Stuart Read and
Dimitrios Cakouros and
Jun R. Huh and
Bruce A. Hay and
Sharad Kumar The role of cytochrome c in caspase
activation in \bionameDrosophila
melanogaster cells . . . . . . . . . . . 1089
Mikio Furuse and
Masaki Hata and
Kyoko Furuse and
Yoko Yoshida and
Akinori Haratake and
Yoshinobu Sugitani and
Tetsuo Noda and
Akiharu Kubo and
Shoichiro Tsukita Claudin-based tight junctions are
crucial for the mammalian epidermal
barrier . . . . . . . . . . . . . . . . 1099
Nicole LeBrasseur Peroxide perturbations . . . . . . . . . ??
Nicole LeBrasseur Clash of the titin . . . . . . . . . . . ??
Nicole LeBrasseur Seeing through the cilium . . . . . . . ??
Nicole LeBrasseur Topo II on the move? . . . . . . . . . . ??
Nicole LeBrasseur p115 SNAREs a vesicle . . . . . . . . . ??
William A. Wells A BAFfling actin function . . . . . . . ??
William A. Wells Sticky polarity . . . . . . . . . . . . ??
William A. Wells A chemokine tug-of-war . . . . . . . . . ??
William A. Wells Make junction, will travel . . . . . . . ??
William A. Wells An ES cell caution . . . . . . . . . . . ??
William A. Wells Is transdifferentiation in trouble? . . 15
Annapaola Franchitto and
Pietro Pichierri Bloom's syndrome protein is required for
correct relocalization of
RAD50/MRE11/NBS1 complex after
replication fork arrest . . . . . . . . 19
Morten O. Christensen and
Morten K. Larsen and
Hans Ullrich Barthelmes and
Robert Hock and
Claus L. Andersen and
Eigil Kjeldsen and
Birgitta R. Knudsen and
Ole Westergaard and
Fritz Boege and
Christian Mielke Dynamics of human DNA topoisomerases II$
\alpha $ and II$ \beta $ in living cells 31
James Shorter and
Matthew B. Beard and
Joachim Seemann and
A. Barbara Dirac-Svejstrup and
Graham Warren Sequential tethering of Golgins and
catalysis of SNAREpin assembly by the
vesicle-tethering protein p115 . . . . . 45
Xinmin Li and
Marcos P. Rivas and
Min Fang and
Jennifer Marchena and
Bharat Mehrotra and
Anu Chaudhary and
Li Feng and
Glenn D. Prestwich and
Vytas A. Bankaitis Analysis of oxysterol binding protein
homologue Kes1p function in regulation
of Sec14p-dependent protein transport
from the yeast Golgi complex . . . . . . 63
Christine Boeddinghaus and
Alexey J. Merz and
Rico Laage and
Christian Ungermann A cycle of Vam7p release from and PtdIns
3-P-dependent rebinding to the yeast
vacuole is required for homotypic
vacuole fusion . . . . . . . . . . . . . 79
Naomi Bishop and
Alistair Horman and
Philip Woodman Mammalian class E vps proteins recognize
ubiquitin and act in the removal of
endosomal protein--ubiquitin conjugates 91
Gregory J. Pazour and
Sheila A. Baker and
James A. Deane and
Douglas G. Cole and
Bethany L. Dickert and
Joel L. Rosenbaum and
George B. Witman and
Joseph C. Besharse The intraflagellar transport protein,
IFT88, is essential for vertebrate
photoreceptor assembly and maintenance 103
John Silke and
Christine J. Hawkins and
Paul G. Ekert and
Joanne Chew and
Catherine L. Day and
Miha Pakusch and
Anne M. Verhagen and
David L. Vaux The anti-apoptotic activity of XIAP is
retained upon mutation of both the
caspase 3-- and caspase $9$--interacting
sites . . . . . . . . . . . . . . . . . 115
Abigail S. McElhinny and
Kazumi Kakinuma and
Hiroyuki Sorimachi and
Siegfried Labeit and
Carol C. Gregorio Muscle-specific RING finger-1 interacts
with titin to regulate sarcomeric M-line
and thick filament structure and may
have nuclear functions via its
interaction with glucocorticoid
modulatory element binding protein-1 . . 125
Elisabeth R. Barton and
Linda Morris and
Antonio Musaro and
Nadia Rosenthal and
H. Lee Sweeney Muscle-specific expression of
insulin-like growth factor I counters
muscle decline in mdx mice . . . . . . . 137
Brian P. Eliceiri and
Xose S. Puente and
John D. Hood and
Dwayne G. Stupack and
David D. Schlaepfer and
Xiaozhu Z. Huang and
Dean Sheppard and
David A. Cheresh Src-mediated coupling of focal adhesion
kinase to integrin $ \alpha $ v $ \beta
$ 5 in vascular endothelial growth
factor signaling . . . . . . . . . . . . 149
Michael H. Roh and
Olga Makarova and
Chia-Jen Liu and
Shin and
Seonok Lee and
Stephanie Laurinec and
Meera Goyal and
Roger Wiggins and
Ben Margolis The Maguk protein, Pals1, functions as
an adapter, linking mammalian homologues
of Crumbs and Discs Lost . . . . . . . . 161
Guangju Ji and
Christopher D. O'Brien and
Morris Feldman and
Yefim Manevich and
Poay Lim and
Jing Sun and
Steven M. Albelda and
Michael I. Kotlikoff PECAM-1 (CD31) regulates a hydrogen
peroxide--activated nonselective cation
channel in endothelial cells . . . . . . 173
Alan W. Dove Consequences of a traffic jam . . . . . ??
Alan W. Dove Utrophin gets a new look . . . . . . . . ??
Alan W. Dove Knowing when to let go . . . . . . . . . ??
Alan W. Dove Adapting to the pit . . . . . . . . . . ??
Alan W. Dove For healthy eyes and bones . . . . . . . ??
Nicole LeBrasseur Learning by palmitoylation . . . . . . . ??
Nicole LeBrasseur Proteases commit microbicide . . . . . . ??
Nicole LeBrasseur Traffic jam suppresses immunity . . . . ??
Nicole LeBrasseur Pressured into making a kidney . . . . . ??
Nicole LeBrasseur From migration to circulation . . . . . ??
Iain M. Cheeseman and
David G. Drubin and
Georjana Barnes Simple centromere, complex kinetochore 199
Hiroki Mori and
Kenneth Cline A twin arginine signal peptide and the
pH gradient trigger reversible assembly
of the thylakoid $ \Delta $ pH/Tat
translocase . . . . . . . . . . . . . . 205
Britta J. Eickholt and
Frank S. Walsh and
Patrick Doherty An inactive pool of GSK-3 at the leading
edge of growth cones is implicated in
Semaphorin 3A signaling . . . . . . . . 211
Eric Rogers and
John D. Bishop and
James A. Waddle and
Jill M. Schumacher and
Rueyling Lin The aurora kinase AIR-2 functions in the
release of chromosome cohesion in
\bionameCaenorhabditis elegans meiosis 219
Peter M. Carlton and
W. Zacheus Cande Telomeres act autonomously in maize to
organize the meiotic bouquet from a
semipolarized chromosome orientation . . 231
Vitold E. Galkin and
Albina Orlova and
Margaret S. VanLoock and
Inna N. Rybakova and
James M. Ervasti and
Edward H. Egelman The utrophin actin-binding domain binds
F-actin in two different modes . . . . . 243
Martin Villalba and
Kun Bi and
Junru Hu and
Yoav Altman and
Paul Bushway and
Eric Reits and
Jacques Neefjes and
Gottfried Baier and
Robert T. Abraham and
Amnon Altman Translocation of PKC$ \theta $ in T
cells is mediated by a nonconventional,
PI3-K- and Vav-dependent pathway, but
does not absolutely require
phospholipase C . . . . . . . . . . . . 253
Achim Obergfell and
Koji Eto and
Attila Mocsai and
Charito Buensuceso and
Sheri L. Moores and
Joan S. Brugge and
Clifford A. Lowell and
Sanford J. Shattil Coordinate interactions of Csk, Src, and
Syk kinases with $ \alpha $IIb$ \beta $3
initiate integrin signaling to the
cytoskeleton . . . . . . . . . . . . . . 265
Rosa Ana Lacalle and
Emilia Mira and
Concepción Gómez-Moutón and
Sonia Jiménez-Baranda and
Carlos Martínez-A. and
Santos Mañes Specific SHP-2 partitioning in raft
domains triggers integrin-mediated
signaling via Rho activation . . . . . . 277
Yvona Ward and
Seow-Fong Yap and
V. Ravichandran and
Fumio Matsumura and
Masaaki Ito and
Beth Spinelli and
Kathleen Kelly The GTP binding proteins Gem and Rad are
negative regulators of the Rho--Rho
kinase pathway . . . . . . . . . . . . . 291
Masaki Kato and
Millan S. Patel and
Regis Levasseur and
Ivan Lobov and
Benny H.-J. Chang and
Donald A. Glass and
Christine Hartmann and
Lan Li and
Tae-Ho Hwang and
Cory F. Brayton and
Richard A. Lang and
Gerard Karsenty and
Lawrence Chan Cbfa1-independent decrease in osteoblast
proliferation, osteopenia, and
persistent embryonic eye vascularization
in mice deficient in Lrp5, a Wnt
coreceptor . . . . . . . . . . . . . . . 303
James P. Howard and
Jenna L. Hutton and
John M. Olson and
Gregory S. Payne Sla1p serves as the targeting signal
recognition factor for NPFX$_{(1, 2)}$
D-mediated endocytosis . . . . . . . . . 315
Mikael Simons and
Eva-Maria Krämer and
Paolo Macchi and
Silvia Rathke-Hartlieb and
Jacqueline Trotter and
Klaus-Armin Nave and
Jörg B. Schulz Overexpression of the myelin proteolipid
protein leads to accumulation of
cholesterol and proteolipid protein in
endosomes/lysosomes . . . . . . . . . . 327
William A. Wells The Golgi's central COG . . . . . . . . ??
William A. Wells Wnt defeats death . . . . . . . . . . . ??
William A. Wells Bring in the SNAREs . . . . . . . . . . ??
William A. Wells Cdc14p turns MEN on and off . . . . . . ??
William A. Wells Death by autophagy . . . . . . . . . . . ??
Nicole LeBrasseur Ras on the inside . . . . . . . . . . . ??
Nicole LeBrasseur Blood cells expand their numbers . . . . ??
Nicole LeBrasseur Exchange is necessary for migration . . ??
Nicole LeBrasseur Suicidal yeast . . . . . . . . . . . . . ??
Nicole LeBrasseur A new member joins the yeast filament
party . . . . . . . . . . . . . . . . . ??
Farrukh A. Chaudhry and
Richard J. Reimer and
Robert H. Edwards The glutamine commute . . . . . . . . . 349
Lisa A. Porter and
Ryan W. Dellinger and
John A. Tynan and
Elizabeth A. Barnes and
Monica Kong and
Jean-Luc Lenormand and
Daniel J. Donoghue Human Speedy . . . . . . . . . . . . . . 357
Gislene Pereira and
Claire Manson and
Joan Grindlay and
Elmar Schiebel Regulation of the Bfa1p--Bub2p complex
at spindle pole bodies by the cell cycle
phosphatase Cdc14p . . . . . . . . . . . 367
Judy K. VanSlyke and
Linda S. Musil Dislocation and degradation from the ER
are regulated by cytosolic stress . . . 381
Ulrike Rein and
Uwe Andag and
Rainer Duden and
Hans Dieter Schmitt and
Anne Spang ARF-GAP-mediated interaction between the
ER--Golgi v--SNAREs and the COPI coat 395
Daniel Ungar and
Toshihiko Oka and
Elizabeth E. Brittle and
Eliza Vasile and
Vladimir V. Lupashin and
Jon E. Chatterton and
John E. Heuser and
Monty Krieger and
M. Gerard Waters Characterization of a mammalian
Golgi-localized protein complex, COG,
that is required for normal Golgi
morphology and function . . . . . . . . 405
Kristina Lindsten and
Femke M. S. de Vrij and
Lisette G. G. C. Verhoef and
David F. Fischer and
Fred W. van Leeuwen and
Elly M. Hol and
Maria G. Masucci and
Nico P. Dantuma Mutant ubiquitin found in
neurodegenerative disorders is a
ubiquitin fusion degradation substrate
that blocks proteasomal degradation . . 417
Zongbing You and
Daniel Saims and
Shaoqiong Chen and
Zhaocheng Zhang and
Denis C. Guttridge and
Kun-liang Guan and
Ormond A. MacDougald and
Anthony M. C. Brown and
Gerard Evan and
Jan Kitajewski and
Cun-Yu Wang Wnt signaling promotes oncogenic
transformation by inhibiting
c--Myc--induced apoptosis . . . . . . . 429
Girish V. Putcha and
Charles A. Harris and
Krista L. Moulder and
Rachael M. Easton and
Craig B. Thompson and
Eugene M. Johnson Intrinsic and extrinsic pathway
signaling during neuronal apoptosis . . 441
Boaz Inbal and
Shani Bialik and
Ilana Sabanay and
Gidi Shani and
Adi Kimchi DAP kinase and DRP-1 mediate membrane
blebbing and the formation of autophagic
vesicles during programmed cell death 455
Mireille Lambert and
Daniel Choquet and
René-Marc M\`ege Dynamics of ligand-induced,
Rac1-dependent anchoring of cadherins to
the actin cytoskeleton . . . . . . . . . 469
Emilio Hirsch and
Laura Barberis and
Mara Brancaccio and
Ornella Azzolino and
Dazhong Xu and
John M. Kyriakis and
Lorenzo Silengo and
Filippo G. Giancotti and
Guido Tarone and
Reinhard Fässler and
Fiorella Altruda Defective Rac-mediated proliferation and
survival after targeted mutation of the
$ \beta_1 $ integrin cytodomain . . . . 481
Dezhi Mu and
Stephanie Cambier and
Lars Fjellbirkeland and
Jody L. Baron and
John S. Munger and
Hisaaki Kawakatsu and
Dean Sheppard and
V. Courtney Broaddus and
Stephen L. Nishimura The integrin $ \alpha $v$ \beta $8
mediates epithelial homeostasis through
MT1-MMP-dependent activation of TGF-$
\beta $1 . . . . . . . . . . . . . . . . 493
Zhuqing Li and
Maria J. Calzada and
John M. Sipes and
Jo Anne Cashel and
Henry C. Krutzsch and
Douglas S. Annis and
Deane F. Mosher and
David D. Roberts Interactions of thrombospondins with $
\alpha $4$ \beta $1 integrin and CD47
differentially modulate T cell behavior 509
Philipp Niethammer and
Markus Delling and
Vladimir Sytnyk and
Alexander Dityatev and
Kiyoko Fukami and
Melitta Schachner Cosignaling of NCAM via lipid rafts and
the FGF receptor is required for
neuritogenesis . . . . . . . . . . . . . 521
Alan W. Dove Turn-ons for axons . . . . . . . . . . . ??
Alan W. Dove Nuclear proteins get around . . . . . . ??
Alan W. Dove Transcription in tight spaces . . . . . ??
Alan W. Dove Arresting development . . . . . . . . . ??
Alan W. Dove A muscular job for spectrin . . . . . . ??
Nicole LeBrasseur Getting a GRIP on kinesin movement . . . ??
Nicole LeBrasseur Playing FtsZ before sporulation . . . . ??
Nicole LeBrasseur Sorting it out, without clathrin . . . . ??
Nicole LeBrasseur Widening the target for cancer treatment ??
Nicole LeBrasseur Connexin the dots . . . . . . . . . . . ??
William A. Wells Stop That Cell . . . . . . . . . . . . . 548
Tarun M. Kapoor and
Duane A. Compton Searching for the middle ground . . . . 551
Keith A. Joiner and
David S. Roos Secretory traffic in the eukaryotic
parasite Toxoplasma gondii . . . . . . . 557
Toshihide Yamashita and
Haruhisa Higuchi and
Masaya Tohyama The p75 receptor transduces the signal
from myelin-associated glycoprotein to
Rho . . . . . . . . . . . . . . . . . . 565
Tetsuro Tamaki and
Akira Akatsuka and
Kiyoshi Ando and
Yoshihiko Nakamura and
Hideyuki Matsuzawa and
Tomomitsu Hotta and
Roland R. Roy and
V. Reggie Edgerton Identification of myogenic-endothelial
progenitor cells in the interstitial
spaces of skeletal muscle . . . . . . . 571
Nicola L. Mahy and
Paul E. Perry and
Susan Gilchrist and
Richard A. Baldock and
Wendy A. Bickmore Spatial organization of active and
inactive genes and noncoding DNA within
chromosome territories . . . . . . . . . 579
Eva Hannak and
Karen Oegema and
Matthew Kirkham and
Pierre Gönczy and
Bianca Habermann and
Anthony A. Hyman The kinetically dominant assembly
pathway for centrosomal asters in
\bionameCaenorhabditis elegans is $
\gamma $-tubulin dependent . . . . . . . 591
Christophe Lefebvre and
M. Emilie Terret and
Alexandre Djiane and
Pascale Rassinier and
Bernard Maro and
Marie-Hél\`ene Verlhac Meiotic spindle stability depends on
MAPK-interacting and spindle-stabilizing
protein (MISS), a new MAPK substrate . . 603
Anthony K. L. Leung and
Angus I. Lamond In vivo analysis of NHPX reveals a novel
nucleolar localization pathway involving
a transient accumulation in splicing
speckles . . . . . . . . . . . . . . . . 615
Elena S. Suvorova and
Rainer Duden and
Vladimir V. Lupashin The Sec34/Sec35p complex, a Ypt1p
effector required for retrograde
intra-Golgi trafficking, interacts with
Golgi SNAREs and COPI vesicle coat
proteins . . . . . . . . . . . . . . . . 631
Renwang Peng and
Dieter Gallwitz Sly1 protein bound to Golgi syntaxin
Sed5p allows assembly and contributes to
specificity of SNARE fusion complexes 645
Boris Hinz and
Giulio Gabbiani and
Christine Chaponnier The NH$_2$-terminal peptide of $ \alpha
$-smooth muscle actin inhibits force
generation by the myofibroblast in vitro
and in vivo . . . . . . . . . . . . . . 657
Kenneth R. Norman and
Donald G. Moerman $ \alpha $ spectrin is essential for
morphogenesis and body wall muscle
formation in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 665
Yufang Shao and
Wendy Akmentin and
Juan Jose Toledo-Aral and
Julie Rosenbaum and
Gregorio Valdez and
John B. Cabot and
Brian S. Hilbush and
Simon Halegoua Pincher, a pinocytic chaperone for nerve
growth factor/TrkA signaling endosomes 679
Jennifer E. Morgan and
Jacqueline G. Gross and
Charles N. Pagel and
Jonathan R. Beauchamp and
Ariberto Fassati and
Adrian J. Thrasher and
James P. Di Santo and
Ivan B. Fisher and
Xu Shiwen and
David J. Abraham and
Terence A. Partridge Myogenic cell proliferation and
generation of a reversible tumorigenic
phenotype are triggered by
preirradiation of the recipient site . . 693
Bryan E. Welm and
Kevin W. Freeman and
Mercy Chen and
Alejandro Contreras and
David M. Spencer and
Jeffrey M. Rosen Inducible dimerization of FGFR1 . . . . 703
Arie Horowitz and
Eugene Tkachenko and
Michael Simons Fibroblast growth factor--specific
modulation of cellular response by
syndecan-4 . . . . . . . . . . . . . . . 715
Nicole LeBrasseur Bundle loss makes turning possible . . . ??
Nicole LeBrasseur Blocking caspase-independent death . . . ??
Nicole LeBrasseur ROCK and Rho will never Dia . . . . . . ??
Nicole LeBrasseur ROCK-steady centriole migration . . . . ??
Nicole LeBrasseur Dynein takes its vimentin . . . . . . . ??
William A. Wells How to make a helix . . . . . . . . . . ??
William A. Wells Cadherins jump into the pool . . . . . . ??
William A. Wells A flipping permease . . . . . . . . . . ??
William A. Wells Attack of the microvesicles . . . . . . ??
William A. Wells The transcription--export link . . . . . ??
Sui Huang Building an efficient factory . . . . . 739
Karel Koberna and
Jan Malínský and
Artem Pliss and
Martin Ma\vsata and
Jaromíra Ve\vce\vrová and
Markéta Fialová and
Jan Bednár and
Ivan Ra\vska Ribosomal genes in focus . . . . . . . . 743
Helder Maiato and
Paula Sampaio and
Catarina L. Lemos and
John Findlay and
Mar Carmena and
William C. Earnshaw and
Claudio E. Sunkel MAST\slash Orbit has a role in
microtubule--kinetochore attachment and
is essential for chromosome alignment
and maintenance of spindle bipolarity 749
Carine Bossenmeyer-Pourié and
Rama Kannan and
Stéphane Ribieras and
Corinne Wendling and
Isabelle Stoll and
Lars Thim and
Catherine Tomasetto and
Marie-Christine Rio The trefoil factor 1 participates in
gastrointestinal cell differentiation by
delaying G1-S phase transition and
reducing apoptosis . . . . . . . . . . . 761
Louis K. Chang and
Eugene M. Johnson Cyclosporin A inhibits
caspase-independent death of
NGF-deprived sympathetic neurons . . . . 771
Ralf Behrens and
Paul Nurse Roles of fission yeast tea1p in the
localization of polarity factors and in
organizing the microtubular cytoskeleton 783
Brian T. Helfand and
Atsushi Mikami and
Richard B. Vallee and
Robert D. Goldman A requirement for cytoplasmic dynein and
dynactin in intermediate filament
network assembly and organization . . . 795
Véronique Chevrier and
Matthieu Piel and
Nora Collomb and
Yasmina Saoudi and
Ronald Frank and
Michel Paintrand and
Shuh Narumiya and
Michel Bornens and
Didier Job The Rho-associated protein kinase
p160ROCK is required for centrosome
positioning . . . . . . . . . . . . . . 807
Takahiro Tsuji and
Toshimasa Ishizaki and
Muneo Okamoto and
Chiharu Higashida and
Kazuhiro Kimura and
Tomoyuki Furuyashiki and
Yoshiki Arakawa and
Raymond B. Birge and
Tetsuya Nakamoto and
Hisamaru Hirai and
Shuh Narumiya ROCK and mDia1 antagonize in
Rho-dependent Rac activation in Swiss
3T3 fibroblasts . . . . . . . . . . . . 819
Olivier Geneste and
John W. Copeland and
Richard Treisman LIM kinase and Diaphanous cooperate to
regulate serum response factor and actin
dynamics . . . . . . . . . . . . . . . . 831
Feng-Quan Zhou and
Clare M. Waterman-Storer and
Christopher S. Cohan Focal loss of actin bundles causes
microtubule redistribution and growth
cone turning . . . . . . . . . . . . . . 839
Zhuqing Qu-Petersen and
Bridget Deasy and
Ron Jankowski and
Makato Ikezawa and
James Cummins and
Ryan Pruchnic and
John Mytinger and
Baohong Cao and
Charley Gates and
Anton Wernig and
Johnny Huard Identification of a novel population of
muscle stem cells in mice . . . . . . . 851
Hagit Niv and
Orit Gutman and
Yoel Kloog and
Yoav I. Henis Activated K--Ras and H--Ras display
different interactions with saturable
nonraft sites at the surface of live
cells . . . . . . . . . . . . . . . . . 865
Jennifer K. Sengbusch and
Wei He and
Karen A. Pinco and
Joy T. Yang Dual functions of $ \alpha $4$ \beta $1
integrin in epicardial development . . . 873
P. Angelo Marangi and
Simon T. Wieland and
Christian Fuhrer Laminin-1 redistributes postsynaptic
proteins and requires rapsyn, tyrosine
phosphorylation, and Src and Fyn to
stably cluster acetylcholine receptors 883
Alan W. Dove Fences catch free-ranging lipids . . . . ??
Alan W. Dove Making straps from small movements . . . ??
Alan W. Dove A vitamin makes minerals . . . . . . . . ??
Alan W. Dove How fish oils work . . . . . . . . . . . ??
Alan W. Dove A prion in yeast Huntington's disease ??
Nicole LeBrasseur Getting sick from Sic . . . . . . . . . ??
Nicole LeBrasseur A time for cytokinesis . . . . . . . . . ??
Nicole LeBrasseur How tumors escape oblivion . . . . . . . ??
Nicole LeBrasseur Slow and steady moves the cell . . . . . ??
Nicole LeBrasseur Desensitizing interactions . . . . . . . ??
Ian Marc Bonapace and
Lucia Latella and
Roberto Papait and
Francesco Nicassio and
Alessandra Sacco and
Masahiro Muto and
Marco Crescenzi and
Pier Paolo Di Fiore Np95 is regulated by E1A during mitotic
reactivation of terminally
differentiated cells and is essential
for S phase entry . . . . . . . . . . . 909
Nicole R. Murray and
Capella Weems and
Lu Chen and
Jessica Leon and
Wangsheng Yu and
Laurie A. Davidson and
Lee Jamieson and
Robert S. Chapkin and
E. Aubrey Thompson and
Alan P. Fields Protein kinase C $ \beta $II and TGF$
\beta $RII in $ \omega $-3 fatty
acid--mediated inhibition of colon
carcinogenesis . . . . . . . . . . . . . 915
Min Zhao and
Tian Jin and
Colin D. McCaig and
John V. Forrester and
Peter N. Devreotes Genetic analysis of the role of G
protein--coupled receptor signaling in
electrotaxis . . . . . . . . . . . . . . 921
Martin Offterdinger and
Christian Schöfer and
Klara Weipoltshammer and
Thomas W. Grunt c-erbB-$3$ . . . . . . . . . . . . . . . 929
Olivier Gadal and
Daniela Strauss and
Elisabeth Petfalski and
Pierre-Emmanuel Gleizes and
Nicole Gas and
David Tollervey and
Ed Hurt Rlp7p is associated with 60S
preribosomes, restricted to the granular
component of the nucleolus, and required
for pre-rRNA processing . . . . . . . . 941
Andrea H. Auchincloss and
William Zerges and
Karl Perron and
Jacqueline Girard-Bascou and
Jean-David Rochaix Characterization of Tbc2, a
nucleus-encoded factor specifically
required for translation of the
chloroplast psbC mRNA in Chlamydomonas
reinhardtii . . . . . . . . . . . . . . 953
Eric D. Schwoebel and
Thai H. Ho and
Mary Shannon Moore The mechanism of inhibition of
Ran-dependent nuclear transport by
cellular ATP depletion . . . . . . . . . 963
Michael Morgan and
Jacqueline Thorburn and
Pier Paolo Pandolfi and
Andrew Thorburn Nuclear and cytoplasmic shuttling of
TRADD induces apoptosis via different
mechanisms . . . . . . . . . . . . . . . 975
Dimitrios Cakouros and
Tasman Daish and
Damali Martin and
Eric H. Baehrecke and
Sharad Kumar Ecdysone-induced expression of the
caspase DRONC during hormone-dependent
programmed cell death in
\bionameDrosophila is regulated by
Broad--Complex . . . . . . . . . . . . . 985
Anatoli B. Meriin and
Xiaoqian Zhang and
Xiangwei He and
Gary P. Newnam and
Yury O. Chernoff and
Michael Y. Sherman Huntingtin toxicity in yeast model
depends on polyglutamine aggregation
mediated by a prion-like protein Rnq1 997
Darinel Ortiz and
Martina Medkova and
Christiane Walch-Solimena and
Peter Novick Ypt32 recruits the Sec4p guanine
nucleotide exchange factor, Sec2p, to
secretory vesicles; evidence for a Rab
cascade in yeast . . . . . . . . . . . . 1005
Stephen R. Cronin and
Rajini Rao and
Randolph Y. Hampton Cod1p\slash Spf1p is a P-type ATPase
involved in ER function and Ca$^{2+}$
homeostasis . . . . . . . . . . . . . . 1017
Anna L. Okorokova Façanha and
Henrik Appelgren and
Mohammad Tabish and
Lev Okorokov and
Karl Ekwall The endoplasmic reticulum cation P-type
ATPase Cta4p is required for control of
cell shape and microtubule dynamics . . 1029
Mette M. Mogensen and
John B. Tucker and
John B. Mackie and
Alan R. Prescott and
Inke S. Näthke The adenomatous polyposis coli protein
unambiguously localizes to microtubule
plus ends and is involved in
establishing parallel arrays of
microtubule bundles in highly polarized
epithelial cells . . . . . . . . . . . . 1041
Ming Zhao and
Stephen E. Harris and
Diane Horn and
Zhaopo Geng and
Riko Nishimura and
Gregory R. Mundy and
Di Chen Bone morphogenetic protein receptor
signaling is necessary for normal murine
postnatal bone formation . . . . . . . . 1049
Wei Wang and
Thorsten Kirsch Retinoic acid stimulates
annexin-mediated growth plate
chondrocyte mineralization . . . . . . . 1061
Takahiro Fujiwara and
Ken Ritchie and
Hideji Murakoshi and
Ken Jacobson and
Akihiro Kusumi Phospholipids undergo hop diffusion in
compartmentalized cell membrane . . . . 1071
Ravi K. Sawhney and
Jonathon Howard Slow local movements of collagen fibers
by fibroblasts drive the rapid global
self-organization of collagen gels . . . 1083
Nicole LeBrasseur Prostate stem cells identified . . . . . ??
Nicole LeBrasseur Bundle up for cytokinesis . . . . . . . ??
Nicole LeBrasseur Lon plays the chaperone . . . . . . . . ??
Nicole LeBrasseur Mapping MAP binding . . . . . . . . . . ??
Nicole LeBrasseur L1 sticks around . . . . . . . . . . . . ??
Rabiya Tuma A Molotov cocktail . . . . . . . . . . . ??
Rabiya Tuma Gluing cells into the niche . . . . . . ??
Rabiya Tuma Cajal body finds its function . . . . . ??
Rabiya Tuma And the winner is \ldots the
phosphatase! . . . . . . . . . . . . . . ??
Rabiya Tuma The nuclear pore as a chromatin boundary ??
Tracey C. Dickson and
C. David Mintz and
Deanna L. Benson and
Stephen R. J. Salton Functional binding interaction
identified between the axonal CAM L1 and
members of the ERM family . . . . . . . 1105
Brian P. Chadwick and
Huntington F. Willard Cell cycle-dependent localization of
macroH2A in chromatin of the inactive X
chromosome . . . . . . . . . . . . . . . 1113
Anja Hagting and
Nicole den Elzen and
Hartmut C. Vodermaier and
Irene C. Waizenegger and
Jan-Michael Peters and
Jonathon Pines Human securin proteolysis is controlled
by the spindle checkpoint and reveals
when the APC/C switches from activation
by Cdc20 to Cdh1 . . . . . . . . . . . . 1125
Jordan W. Raff and
Kim Jeffers and
Jun-yong Huang The roles of Fzy/Cdc20 and Fzr/Cdh1 in
regulating the destruction of cyclin B
in space and time . . . . . . . . . . . 1139
Osamu Hori and
Fusae Ichinoda and
Takashi Tamatani and
Atsushi Yamaguchi and
Naoya Sato and
Kentaro Ozawa and
Yasuko Kitao and
Mayuki Miyazaki and
Heather P. Harding and
David Ron and
Masaya Tohyama and
David M. Stern and
Satoshi Ogawa Transmission of cell stress from
endoplasmic reticulum to mitochondria 1151
Joyce M. M. Müller and
James Shorter and
Richard Newman and
Katrin Deinhardt and
Yuval Sagiv and
Zvulun Elazar and
Graham Warren and
David T. Shima Sequential SNARE disassembly and
GATE-16--GOS-28 complex assembly
mediated by distinct NSF activities
drives Golgi membrane fusion . . . . . . 1161
Cristiana Mollinari and
Jean-Philippe Kleman and
Wei Jiang and
Guy Schoehn and
Tony Hunter and
Robert L. Margolis PRC1 is a microtubule binding and
bundling protein essential to maintain
the mitotic spindle midzone . . . . . . 1175
Jawdat Al-Bassam and
Rachel S. Ozer and
Daniel Safer and
Shelley Halpain and
Ronald A. Milligan MAP2 and tau bind longitudinally along
the outer ridges of microtubule
protofilaments . . . . . . . . . . . . . 1187
Pascal Steiner and
J.-C. Floyd Sarria and
Liliane Glauser and
Sarah Magnin and
Stefan Catsicas and
Harald Hirling Modulation of receptor cycling by
neuron-enriched endosomal protein of 21
kD . . . . . . . . . . . . . . . . . . . 1197
László Hunyady and
Albert J. Baukal and
Zsuzsanna Gáborik and
Jesus A. Olivares-Reyes and
Márta Bor and
Márta Szaszák and
Robert Lodge and
Kevin J. Catt and
Tamas Balla Differential PI $3$-kinase dependence of
early and late phases of recycling of
the internalized AT$_1$ angiotensin
receptor . . . . . . . . . . . . . . . . 1211
Andrew W. Schaefer and
Yoshimasa Kamei and
Hiroyuki Kamiguchi and
Eric V. Wong and
Iris Rapoport and
Tomas Kirchhausen and
Carol M. Beach and
Gary Landreth and
Sandra K. Lemmon and
Vance Lemmon L1 endocytosis is controlled by a
phosphorylation-dephosphorylation cycle
stimulated by outside-in signaling by L1 1223
Olga Barreiro and
María Yáñez-Mó and
Juan M. Serrador and
María C. Montoya and
Miguel Vicente-Manzanares and
Reyes Tejedor and
Heinz Furthmayr and
Francisco Sánchez-Madrid Dynamic interaction of VCAM-1 and ICAM-1
with moesin and ezrin in a novel
endothelial docking structure for
adherent leukocytes . . . . . . . . . . 1233
Leora Gollan and
Helena Sabanay and
Sebastian Poliak and
Erik O. Berglund and
Barbara Ranscht and
Elior Peles Retention of a cell adhesion complex at
the paranodal junction requires the
cytoplasmic region of Caspr . . . . . . 1247
Akira Tsujimura and
Yasuhiro Koikawa and
Sarah Salm and
Tetsuya Takao and
Sandra Coetzee and
David Moscatelli and
Ellen Shapiro and
Herbert Lepor and
Tung-Tien Sun and
E. Lynette Wilson Proximal location of mouse prostate
epithelial stem cells . . . . . . . . . 1257
Donna L. Cioffi and
Timothy M. Moore and
Jerry Schaack and
Judy R. Creighton and
Dermot M. F. Cooper and
Troy Stevens Dominant regulation of interendothelial
cell gap formation by calcium-inhibited
type 6 adenylyl cyclase . . . . . . . . 1267
Shaohua Li and
David Harrison and
Salvatore Carbonetto and
Reinhard Fässler and
Neil Smyth and
David Edgar and
Peter D. Yurchenco Matrix assembly, regulation, and
survival functions of laminin and its
receptors in embryonic stem cell
differentiation . . . . . . . . . . . . 1279
Alan W. Dove The needs of the pore . . . . . . . . . ??
Alan W. Dove Only one way to organize a movement? . . ??
Alan W. Dove Another way to break down . . . . . . . ??
Alan W. Dove Coordinating myosin with mitosis . . . . ??
Alan W. Dove Topoisomerase gets around . . . . . . . ??
Nicole LeBrasseur Bacteria tear down microtubules . . . . ??
Nicole LeBrasseur Arteries play follow the leader . . . . ??
Nicole LeBrasseur Stable globin needs a partner . . . . . ??
Nicole LeBrasseur Ubiquitin receptor found . . . . . . . . ??
Nicole LeBrasseur Securin correct separation . . . . . . . ??
Ira Mellman and
Anne Ridley Regulation and Functional Insights in
Cellular Polarity Madrid, Spain June
3--5, 2002 . . . . . . . . . . . . . . . 12
Susan S. Smyth and
Cam Patterson Tiny dancers . . . . . . . . . . . . . . 17
Penny A. Tavormina and
Marie-George Côme and
Joanna R. Hudson and
Yin-Yuan Mo and
William T. Beck and
Gary J. Gorbsky Rapid exchange of mammalian
topoisomerase II$ \alpha $ at
kinetochores and chromosome arms in
mitosis . . . . . . . . . . . . . . . . 23
Wendy C. Salmon and
Michael C. Adams and
Clare M. Waterman-Storer Dual-wavelength fluorescent speckle
microscopy reveals coupling of
microtubule and actin movements in
migrating cells . . . . . . . . . . . . 31
Andrea D. Weston and
Roshantha A. S. Chandraratna and
Joseph Torchia and
T. Michael Underhill Requirement for RAR-mediated gene
repression in skeletal progenitor
differentiation . . . . . . . . . . . . 39
Sheona P. Drummond and
Katherine L. Wilson Interference with the cytoplasmic tail
of gp210 disrupts ``close apposition''
of nuclear membranes and blocks nuclear
pore dilation . . . . . . . . . . . . . 53
Tobias C. Walther and
Helen S. Pickersgill and
Volker C. Cordes and
Martin W. Goldberg and
Terry D. Allen and
Iain W. Mattaj and
Maarten Fornerod The cytoplasmic filaments of the nuclear
pore complex are dispensable for
selective nuclear protein import . . . . 63
Qi Chen and
Hideo Kimura and
David Schubert A novel mechanism for the regulation of
amyloid precursor protein metabolism . . 79
Cole M. Haynes and
Sabrina Caldwell and
Antony A. Cooper An HRD /DER-independent ER quality
control mechanism involves
Rsp5p-dependent ubiquitination and
ER--Golgi transport . . . . . . . . . . 91
Jian Li and
Michel Pucéat and
Carmen Perez-Terzic and
Annabelle Mery and
Kimitoshi Nakamura and
Marek Michalak and
Karl-Heinz Krause and
Marisa E. Jaconi Calreticulin reveals a critical
Ca$^{2+}$ checkpoint in cardiac
myofibrillogenesis . . . . . . . . . . . 103
Raffi Gugasyan and
Cathy Quilici and
Stacey T. T. I. and
Dianne Grail and
Anne M. Verhagen and
Andrew Roberts and
Toshio Kitamura and
Ashley R. Dunn and
Peter Lock Dok-related protein negatively regulates
T cell development via its
RasGTPase-activating protein and Nck
docking sites . . . . . . . . . . . . . 115
Anne Royou and
William Sullivan and
Roger Karess Cortical recruitment of nonmuscle myosin
II in early syncytial \bionameDrosophila
embryos . . . . . . . . . . . . . . . . 127
Andrew W. Schaefer and
Nurul Kabir and
Paul Forscher Filopodia and actin arcs guide the
assembly and transport of two
populations of microtubules with unique
dynamic parameters in neuronal growth
cones . . . . . . . . . . . . . . . . . 139
Akira Katsumi and
Julie Milanini and
William B. Kiosses and
Miguel A. del Pozo and
Roland Kaunas and
Shu Chien and
Klaus M. Hahn and
Martin Alexander Schwartz Effects of cell tension on the small
GTPase Rac . . . . . . . . . . . . . . . 153
Jun Chung and
Robin E. Bachelder and
Elizabeth A. Lipscomb and
Leslie M. Shaw and
Arthur M. Mercurio Integrin ($ \alpha $6$ \beta $4)
regulation of eIF-4E activity and VEGF
translation . . . . . . . . . . . . . . 165
Alan W. Dove New tricks for old neurons . . . . . . . ??
Alan W. Dove A glue for microtubule cargos . . . . . ??
Alan W. Dove Another name for autotaxin . . . . . . . ??
Alan W. Dove Signaling from strange places . . . . . ??
Alan W. Dove Watching Ca$^{2+}$ waves break . . . . . ??
William A. Wells Plasmid segregation actin' up . . . . . ??
William A. Wells Nervous chemokines . . . . . . . . . . . ??
William A. Wells Condensin wraps it up . . . . . . . . . ??
William A. Wells Attack of the waves . . . . . . . . . . ??
William A. Wells Let there be a channel . . . . . . . . . ??
Wouter H. Moolenaar Lysophospholipids in the limelight . . . 197
Igor Prudovsky and
Cinzia Bagala and
Francesca Tarantini and
Anna Mandinova and
Raffaella Soldi and
Stephen Bellum and
Thomas Maciag The intracellular translocation of the
components of the fibroblast growth
factor 1 release complex precedes their
assembly prior to export . . . . . . . . 201
Gundula Rohde and
Dirk Wenzel and
Volker Haucke A phosphatidylinositol
(4,5)-bisphosphate binding site within $
\mu $2-adaptin regulates
clathrin-mediated endocytosis . . . . . 209
Sayaka Ueno and
Masako Tsukamoto and
Tomoya Hirano and
Kazuya Kikuchi and
Maki K. Yamada and
Nobuyoshi Nishiyama and
Tetsuo Nagano and
Norio Matsuki and
Yuji Ikegaya Mossy fiber Zn$^{2+}$ spillover
modulates heterosynaptic
N-methyl-d-aspartate receptor activity
in hippocampal CA3 circuits . . . . . . 215
Yibing Yan and
Kyoko Shirakabe and
Zena Werb The metalloprotease Kuzbanian (ADAM10)
mediates the transactivation of EGF
receptor by G protein--coupled receptors 221
Makiko Umezu-Goto and
Yasuhiro Kishi and
Akitsu Taira and
Kotaro Hama and
Naoshi Dohmae and
Koji Takio and
Takao Yamori and
Gordon B. Mills and
Keizo Inoue and
Junken Aoki and
Hiroyuki Arai Autotaxin has lysophospholipase D
activity leading to tumor cell growth
and motility by lysophosphatidic acid
production . . . . . . . . . . . . . . . 227
J.-C. Bourdon and
J. Renzing and
P. L. Robertson and
K. N. Fernandes and
D. P. Lane Scotin, a novel p53-inducible
proapoptotic protein located in the ER
and the nuclear membrane . . . . . . . . 235
Maurizio Molinari and
Carmela Galli and
Verena Piccaluga and
Michel Pieren and
Paolo Paganetti Sequential assistance of molecular
chaperones and transient formation of
covalent complexes during protein
degradation from the ER . . . . . . . . 247
Jennifer J. Smith and
Marcello Marelli and
Rowan H. Christmas and
Franco J. Vizeacoumar and
David J. Dilworth and
Trey Ideker and
Timothy Galitski and
Krassen Dimitrov and
Richard A. Rachubinski and
John D. Aitchison Transcriptome profiling to identify
genes involved in peroxisome assembly
and function . . . . . . . . . . . . . . 259
Lara K. Mahal and
Sonia M. Sequeira and
Jodi M. Gureasko and
Thomas H. Söllner Calcium-independent stimulation of
membrane fusion and SNAREpin formation
by synaptotagmin I . . . . . . . . . . . 273
Michael C. Ashby and
Madeleine Craske and
Myoung Kyu Park and
Oleg V. Gerasimenko and
Robert D. Burgoyne and
Ole H. Petersen and
Alexei V. Tepikin Localized Ca$^{2+}$ uncaging reveals
polarized distribution of
Ca$^{2+}$-sensitive Ca$^{2+}$ release
sites . . . . . . . . . . . . . . . . . 283
Ying Xu and
Sen Takeda and
Takao Nakata and
Yasuko Noda and
Yosuke Tanaka and
Nobutaka Hirokawa Role of KIFC3 motor protein in Golgi
positioning and integration . . . . . . 293
Patricia S. Vaughan and
Pedro Miura and
Matthew Henderson and
Belinda Byrne and
Kevin T. Vaughan A role for regulated binding of p150
$^{\rm Glued}$ to microtubule plus ends
in organelle transport . . . . . . . . . 305
Hiroyuki Tanaka and
Toshihide Yamashita and
Minoru Asada and
Shuki Mizutani and
Hideki Yoshikawa and
Masaya Tohyama Cytoplasmic p21$^{\rm Cip1} \slash W A
F1$ regulates neurite remodeling by
inhibiting Rho-kinase activity . . . . . 321
Ramanuj DasGupta and
Horace Rhee and
Elaine Fuchs A developmental conundrum . . . . . . . 331
Mina Ryten and
Philip M. Dunn and
Joseph T. Neary and
Geoffrey Burnstock ATP regulates the differentiation of
mammalian skeletal muscle by activation
of a P2X$_5$ receptor on satellite cells 345
Erica Werner and
Zena Werb Integrins engage mitochondrial function
for signal transduction by a mechanism
dependent on Rho GTPases . . . . . . . . 357
Alan W. Dove CAST into the synapse . . . . . . . . . ??
Alan W. Dove Getting trapped in a rough neighborhood ??
Alan W. Dove Two channels, one program . . . . . . . ??
Alan W. Dove BAF goes nuclear . . . . . . . . . . . . ??
Alan W. Dove A new path for endostatin . . . . . . . ??
Nicole LeBrasseur A molecule with a sense of timing . . . ??
Nicole LeBrasseur Active cells choose life . . . . . . . . ??
Nicole LeBrasseur Coordination of replication . . . . . . ??
Nicole LeBrasseur The ER contributes to engulfment . . . . ??
Nicole LeBrasseur Decoding Ca$^{2+}$ signals through cAMP ??
Jorge E. Galán The cell biology of microbial infections 387
Norma W. Andrews Lysosomes and the plasma membrane . . . 389
Martin Bushell and
Peter Sarnow Hijacking the translation apparatus by
RNA viruses . . . . . . . . . . . . . . 395
Guy R. Cornelis Yersinia type III secretion . . . . . . 401
Daniel A. Portnoy and
Victoria Auerbuch and
Ian J. Glomski The cell biology of \bionameListeria
monocytogenes infection . . . . . . . . 409
Craig R. Roy and
Lewis G. Tilney The road less traveled . . . . . . . . . 415
David G. Russell and
Henry C. Mwandumba and
Elizabeth E. Rhoades Mycobacterium and the coat of many
lipids . . . . . . . . . . . . . . . . . 421
Jianqing Ding and
Jia-Jia Liu and
Anthony S. Kowal and
Timothy Nardine and
Priyanka Bhattacharya and
Arthur Lee and
Yanmin Yang Microtubule-associated protein 1B . . . 427
Eric Rutledge and
Jerod Denton and
Kevin Strange Cell cycle-- and swelling-induced
activation of a \bionameCaenorhabditis
elegans ClC channel is mediated by
CeGLC-7$ \alpha $ /$ \beta $
phosphatases . . . . . . . . . . . . . . 435
Quinton Tieu and
Voytek Okreglak and
Kari Naylor and
Jodi Nunnari The WD repeat protein, Mdv1p, functions
as a molecular adaptor by interacting
with Dnm1p and Fis1p during
mitochondrial fission . . . . . . . . . 445
M. Palmada and
S. Kanwal and
N. J. Rutkoski and
C. Gustafson-Brown and
R. S. Johnson and
R. Wisdom and
B. D. Carter c-jun is essential for sympathetic
neuronal death induced by NGF withdrawal
but not by p75 activation . . . . . . . 453
Beata Fuchsová and
Petr Novák and
Jarmila Kafková and
Pavel Hozák Nuclear DNA helicase II is recruited to
IFN-$ \alpha $-activated transcription
sites at PML nuclear bodies . . . . . . 463
Miriam Segura-Totten and
Amy K. Kowalski and
Robert Craigie and
Katherine L. Wilson Barrier-to-autointegration factor . . . 475
Rey-Huei Chen BubR1 is essential for kinetochore
localization of other spindle checkpoint
proteins and its phosphorylation
requires Mad1 . . . . . . . . . . . . . 487
Andrei V. Nikonov and
Erik Snapp and
Jennifer Lippincott-Schwartz and
Gert Kreibich Active translocon complexes labeled with
GFP--Dad1 diffuse slowly as large
polysome arrays in the endoplasmic
reticulum . . . . . . . . . . . . . . . 497
Sean P. Cregan and
Andre Fortin and
Jason G. MacLaurin and
Steven M. Callaghan and
Francesco Cecconi and
Seong-Woon Yu and
Ted M. Dawson and
Valina L. Dawson and
David S. Park and
Guido Kroemer and
Ruth S. Slack Apoptosis-inducing factor is involved in
the regulation of caspase-independent
neuronal cell death . . . . . . . . . . 507
Amélie Robert and
Marie-Joëlle Miron and
Claudia Champagne and
Marie-Claude Gingras and
Philip E. Branton and
Josée N. Lavoie Distinct cell death pathways triggered
by the adenovirus early region 4 ORF 4
protein . . . . . . . . . . . . . . . . 519
Jun-ichi Hanai and
Joachim Gloy and
S. Ananth Karumanchi and
Sujata Kale and
Jian Tang and
Guang Hu and
Barden Chan and
Ramani Ramchandran and
Vivek Jha and
Vikas P. Sukhatme and
Sergei Sokol Endostatin is a potential inhibitor of
Wnt signaling . . . . . . . . . . . . . 529
Akihiro Harada and
Junlin Teng and
Yosuke Takei and
Keiko Oguchi and
Nobutaka Hirokawa MAP2 is required for dendrite
elongation, PKA anchoring in dendrites,
and proper PKA signal transduction . . . 541
Christoph Kaether and
Sven Lammich and
Dieter Edbauer and
Michaela Ertl and
Jens Rietdorf and
Anja Capell and
Harald Steiner and
Christian Haass Presenilin-1 affects trafficking and
processing of $ \beta $APP and is
targeted in a complex with nicastrin to
the plasma membrane . . . . . . . . . . 551
Sathyamangla V. Naga Prasad and
Stéphane A. Laporte and
Dean Chamberlain and
Marc G. Caron and
Larry Barak and
Howard A. Rockman Phosphoinositide $3$-kinase regulates $
\beta $2-adrenergic receptor endocytosis
by AP-2 recruitment to the receptor/$
\beta $-arrestin complex . . . . . . . . 563
Toshihisa Ohtsuka and
Etsuko Takao-Rikitsu and
Eiji Inoue and
Marie Inoue and
Masakazu Takeuchi and
Kaho Matsubara and
Maki Deguchi-Tawarada and
Keiko Satoh and
Koji Morimoto and
Hiroyuki Nakanishi and
Yoshimi Takai Cast . . . . . . . . . . . . . . . . . . 577
Nicole LeBrasseur Rabs make their way to mitochondria . . ??
Nicole LeBrasseur Quantity assurance . . . . . . . . . . . ??
Nicole LeBrasseur PECAM-1 senses the pressure . . . . . . ??
Nicole LeBrasseur ABU to perform under stress . . . . . . ??
Nicole LeBrasseur Selectin flexible cells . . . . . . . . ??
William A. Wells A mitochondrial ratchet . . . . . . . . ??
William A. Wells The numbers come to light . . . . . . . ??
William A. Wells Is that a fly in your leg? . . . . . . . ??
William A. Wells Stop and die . . . . . . . . . . . . . . ??
William A. Wells Brave new eggs . . . . . . . . . . . . . ??
William A. Wells The youth revolution . . . . . . . . . . 609
Hudson H. Freeze Sweet solution . . . . . . . . . . . . . 615
Thomas A. Kufer and
Herman H. W. Silljé and
Roman Körner and
Oliver J. Gruss and
Patrick Meraldi and
Erich A. Nigg Human TPX2 is required for targeting
Aurora--A kinase to the spindle . . . . 617
Shwetal Mehta and
Xian Mei Yang and
Clarence S. Chan and
Melanie J. Dobson and
Makkuni Jayaram and
Soundarapandian Velmurugan The 2 micron plasmid purloins the yeast
cohesin complex . . . . . . . . . . . . 625
Fumihiko Urano and
Marcella Calfon and
Takunari Yoneda and
Chi Yun and
Moni Kiraly and
Scott G. Clark and
David Ron A survival pathway for
\bionameCaenorhabditis elegans with a
blocked unfolded protein response . . . 639
Björn Schwer and
Brian J. North and
Roy A. Frye and
Melanie Ott and
Eric Verdin The human silent information regulator
(Sir)2 homologue hSIRT3 is a
mitochondrial nicotinamide adenine
dinucleotide-dependent deacetylase . . . 647
Neal M. Alto and
Jacquelyn Soderling and
John D. Scott Rab32 is an A-kinase anchoring protein
and participates in mitochondrial
dynamics . . . . . . . . . . . . . . . . 659
Gary Eitzen and
Li Wang and
Naomi Thorngren and
William Wickner Remodeling of organelle-bound actin is
required for yeast vacuole fusion . . . 669
Mala V. Rao and
Michael L. Garcia and
Yukio Miyazaki and
Takahiro Gotow and
Aidong Yuan and
Salvatore Mattina and
Chris M. Ward and
Nigel A. Calcutt and
Yasuo Uchiyama and
Ralph A. Nixon and
Don W. Cleveland Gene replacement in mice reveals that
the heavily phosphorylated tail of
neurofilament heavy subunit does not
affect axonal caliber or the transit of
cargoes in slow axonal transport . . . . 681
Matthew Kofron and
Janet Heasman and
Stephanie A. Lang and
Christopher C. Wylie Plakoglobin is required for maintenance
of the cortical actin skeleton in early
\bionameXenopus embryos and for
cdc42-mediated wound healing . . . . . . 695
Stéphane Genoud and
Corinna Lappe-Siefke and
Sandra Goebbels and
Freddy Radtke and
Michel Aguet and
Steven S. Scherer and
Ueli Suter and
Klaus-Armin Nave and
Ned Mantei Notch1 control of oligodendrocyte
differentiation in the spinal cord . . . 709
J. M. Edgar and
T. J. Anderson and
P. J. Dickinson and
J. A. Barrie and
M. C. McCulloch and
K.-A. Nave and
I. R. Griffiths Survival of, and competition between,
oligodendrocytes expressing different
alleles of the Plp gene . . . . . . . . 719
Rita Gallo and
Francesca Zazzeroni and
Edoardo Alesse and
Claudia Mincione and
Ugo Borello and
Pasquale Buanne and
Roberta D'Eugenio and
Andrew R. Mackay and
Beatrice Argenti and
Roberto Gradini and
Matteo A. Russo and
Marella Maroder and
Giulio Cossu and
Luigi Frati and
Isabella Screpanti and
Alberto Gulino Ren . . . . . . . . . . . . . . . . . . 731
Emmanuel Laplantine and
Ferdinand Rossi and
Malika Sahni and
Claudio Basilico and
David Cobrinik FGF signaling targets the pRb-related
p107 and p130 proteins to induce
chondrocyte growth arrest . . . . . . . 741
Thorsten Lang and
Martin Margittai and
Helmut Hölzler and
Reinhard Jahn SNAREs in native plasma membranes are
active and readily form core complexes
with endogenous and exogenous SNAREs . . 751
Andrew E. Wurmser and
Scott D. Emr Novel PtdIns(3)P-binding protein Etf1
functions as an effector of the Vps34
PtdIns $3$-kinase in autophagy . . . . . 761
Masaki Osawa and
Michitaka Masuda and
Ken-ichi Kusano and
Keigi Fujiwara Evidence for a role of platelet
endothelial cell adhesion molecule-1 in
endothelial cell mechanosignal
transduction . . . . . . . . . . . . . . 773
Tadayuki Yago and
Anne Leppänen and
Haiying Qiu and
Warren D. Marcus and
Matthias U. Nollert and
Cheng Zhu and
Richard D. Cummings and
Rodger P. McEver Distinct molecular and cellular
contributions to stabilizing
selectin-mediated rolling under flow . . 787
Peter L. Smith and
Jay T. Myers and
Clare E. Rogers and
Lan Zhou and
Bronia Petryniak and
Daniel J. Becker and
Jonathon W. Homeister and
John B. Lowe Conditional control of selectin ligand
expression and global fucosylation
events in mice with a targeted mutation
at the FX locus . . . . . . . . . . . . 801
Alan W. Dove Protecting the ends . . . . . . . . . . ??
Alan W. Dove Less is pore . . . . . . . . . . . . . . ??
Alan W. Dove A zipper designed to snag . . . . . . . ??
Alan W. Dove Crumbs under the skin . . . . . . . . . ??
Alan W. Dove Unattached kinetochore seeks short-term
relationship . . . . . . . . . . . . . . ??
Nicole LeBrasseur Seeing in motion . . . . . . . . . . . . ??
Nicole LeBrasseur Traveling backward . . . . . . . . . . . ??
Nicole LeBrasseur When LDH says ``open,'' channels listen ??
Nicole LeBrasseur Neurons are translationally smart . . . ??
Nicole LeBrasseur Lipids tell channel to open wide . . . . ??
R. C. Liddington and
M. H. Ginsberg Integrin activation takes shape . . . . 833
Marko J. Kallio and
Victoria A. Beardmore and
Jasminder Weinstein and
Gary J. Gorbsky Rapid microtubule-independent dynamics
of Cdc20 at kinetochores and centrosomes
in mammalian cells . . . . . . . . . . . 841
Jan Peter Siebrasse and
Elias Coutavas and
Reiner Peters Reconstitution of nuclear protein export
in isolated nuclear envelopes . . . . . 849
Sylwia Wasiak and
Valerie Legendre-Guillemin and
Rosa Puertollano and
François Blondeau and
Martine Girard and
Elaine de Heuvel and
Daniel Boismenu and
Alexander W. Bell and
Juan S. Bonifacino and
Peter S. McPherson Enthoprotin . . . . . . . . . . . . . . 855
Matthew P. Stokes and
Ruth Van Hatten and
Howard D. Lindsay and
W. Matthew Michael DNA replication is required for the
checkpoint response to damaged DNA in
\bionameXenopus egg extracts . . . . . . 863
Stephen L. Rogers and
Gregory C. Rogers and
David J. Sharp and
Ronald D. Vale Drosophila EB1 is important for proper
assembly, dynamics, and positioning of
the mitotic spindle . . . . . . . . . . 873
Eric L. Weiss and
Cornelia Kurischko and
Chao Zhang and
Kevan Shokat and
David G. Drubin and
Francis C. Luca The \bionameSaccharomyces cerevisiae
Mob2p--Cbk1p kinase complex promotes
polarized growth and acts with the
mitotic exit network to facilitate
daughter cell--specific localization of
Ace2p transcription factor . . . . . . . 885
Ulrike Gruneberg and
Michael Glotzer and
Anton Gartner and
Erich A. Nigg The CeCDC-14 phosphatase is required for
cytokinesis in the
\bionameCaenorhabditis elegans embryo 901
Janet M. Cronshaw and
Andrew N. Krutchinsky and
Wenzhu Zhang and
Brian T. Chait and
Michael J. Matunis Proteomic analysis of the mammalian
nuclear pore complex . . . . . . . . . . 915
Thomas J. Melia and
Thomas Weber and
James A. McNew and
Lillian E. Fisher and
Robert J. Johnston and
Frank Parlati and
Lara K. Mahal and
Thomas H. Söllner and
James E. Rothman Regulation of membrane fusion by the
membrane-proximal coil of the t--SNARE
during zippering of SNAREpins . . . . . 929
Emmanuelle Médina and
Janice Williams and
Elizabeth Klipfell and
Daniela Zarnescu and
Graham Thomas and
André Le Bivic Crumbs interacts with moesin and $
\beta_{Heavy} $-spectrin in the apical
membrane skeleton of \bionameDrosophila 941
Sophie Charrasse and
Mayya Meriane and
Franck Comunale and
Anne Blangy and
Cécile Gauthier-Rouvi\`ere N-cadherin-dependent cell--cell contact
regulates Rho GTPases and $ \beta
$-catenin localization in mouse C2C12
myoblasts . . . . . . . . . . . . . . . 953
Viyada Nunbhakdi-Craig and
Thomas Machleidt and
Egon Ogris and
Dennis Bellotto and
Charles L. White and
Estelle Sontag Protein phosphatase 2A associates with
and regulates atypical PKC and the
epithelial tight junction complex . . . 967
Nicole LeBrasseur Microtubules get swept up in the
excitement of mitosis . . . . . . . . . ??
Nicole LeBrasseur COPs are held up by Sec16p . . . . . . . ??
Nicole LeBrasseur Pinosomes help a virus escape . . . . . ??
Nicole LeBrasseur DEDD spells death to caspase substrates ??
Nicole LeBrasseur Gnawing at the bone . . . . . . . . . . ??
William A. Wells Comm with me . . . . . . . . . . . . . . ??
William A. Wells RNAi takes on DNA . . . . . . . . . . . ??
William A. Wells A titinic extension . . . . . . . . . . ??
William A. Wells Channeling hedgehogs . . . . . . . . . . ??
William A. Wells Send Me a Message: The FASEB Conference
on Signal Transduction Salt Lake City,
UT June 29--July 3, 2002 . . . . . . . . 994
Nasser M. Rusan and
U. Serdar Tulu and
Carey Fagerstrom and
Patricia Wadsworth Reorganization of the microtubule array
in prophase/prometaphase requires
cytoplasmic dynein-dependent microtubule
transport . . . . . . . . . . . . . . . 997
François Nédélec Computer simulations reveal motor
properties generating stable
antiparallel microtubule interactions 1005
Sean P. Curran and
Danielle Leuenberger and
Einhard Schmidt and
Carla M. Koehler The role of the Tim8p--Tim13p complex in
a conserved import pathway for
mitochondrial polytopic inner membrane
proteins . . . . . . . . . . . . . . . . 1017
Frantisek Supek and
David T. Madden and
Susan Hamamoto and
Lelio Orci and
Randy Schekman Sec16p potentiates the action of COPII
proteins to bud transport vesicles . . . 1029
Hervé Le Stunff and
Ismael Galve-Roperh and
Courtney Peterson and
Sheldon Milstien and
Sarah Spiegel Sphingosine-1-phosphate phosphohydrolase
in regulation of sphingolipid metabolism
and apoptosis . . . . . . . . . . . . . 1039
Justine C. Lee and
Olaf Schickling and
Alexander H. Stegh and
Robert G. Oshima and
David Dinsdale and
Gerald M. Cohen and
Marcus E. Peter DEDD regulates degradation of
intermediate filaments during apoptosis 1051
Margaret S. Lee and
Karen A. D'Amour and
Jackie Papkoff A yeast model system for functional
analysis of $ \beta $-catenin signaling 1067
Hans R. Widlund and
Martin A. Horstmann and
E. Roydon Price and
Junqing Cui and
Stephen L. Lessnick and
Min Wu and
Xi He and
David E. Fisher $ \beta $-Catenin-induced melanoma
growth requires the downstream target
\bionameMicrophthalmia-associated
transcription factor . . . . . . . . . . 1079
Clarisse Vandebrouck and
Dominique Martin and
Monique Colson-Van Schoor and
Huguette Debaix and
Philippe Gailly Involvement of TRPC in the abnormal
calcium influx observed in dystrophic
(mdx) mouse skeletal muscle fibers . . . 1089
Yukio Hosaka and
Toshifumi Yokota and
Yuko Miyagoe-Suzuki and
Katsutoshi Yuasa and
Michihiro Imamura and
Ryoichi Matsuda and
Takaaki Ikemoto and
Shuhei Kameya and
Shin'ichi Takeda $ \alpha $1-Syntrophin--deficient
skeletal muscle exhibits hypertrophy and
aberrant formation of neuromuscular
junctions during regeneration . . . . . 1097
Jacinthe Gingras and
Siamak Rassadi and
Ellis Cooper and
Michael Ferns Agrin plays an organizing role in the
formation of sympathetic synapses . . . 1109
Oliver Meier and
Karin Boucke and
Silvija Vig Hammer and
Stephan Keller and
Robert P. Stidwill and
Silvio Hemmi and
Urs F. Greber Adenovirus triggers macropinocytosis and
endosomal leakage together with its
clathrin-mediated uptake . . . . . . . . 1119
Paola Spessotto and
Francesca Maria Rossi and
Massimo Degan and
Raffaele Di Francia and
Roberto Perris and
Alfonso Colombatti and
Valter Gattei Hyaluronan-CD44 interaction hampers
migration of osteoclast-like cells by
down-regulating MMP-9 . . . . . . . . . 1133
Mike Rossner Figure manipulation . . . . . . . . . . 1151
Alan W. Dove Birth control for centrioles . . . . . . ??
Alan W. Dove Signaling clusters caught in the act . . ??
Alan W. Dove Herpes spoils excitement . . . . . . . . ??
Alan W. Dove Finding a heat-shock absorber . . . . . ??
Alan W. Dove An endosomal switchboard . . . . . . . . ??
Nicole LeBrasseur Hiding telomerase from chromatin . . . . ??
Nicole LeBrasseur Semaphorins --- not just for axons . . . ??
Nicole LeBrasseur Promiscuous Ras turns on the wrong
partner . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur SynCAM and sidekick synchronize synapse
synthesis . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Stand up and take hold . . . . . . . . . ??
William A. Wells Does size matter? . . . . . . . . . . . 1156
Yali Dou and
Josephine Bowen and
Yifan Liu and
Martin A. Gorovsky Phosphorylation and an ATP-dependent
process increase the dynamic exchange of
H1 in chromatin . . . . . . . . . . . . 1161
Alexey Khodjakov and
Conly L. Rieder and
Greenfield Sluder and
Grisel Cassels and
Ody Sibon and
Chuo-Lung Wang De novo formation of centrosomes in
vertebrate cells arrested during S phase 1171
Pascale Dupuis-Williams and
Anne Fleury-Aubusson and
Nicole Garreau de Loubresse and
Hél\`ene Geoffroy and
Laurence Vayssié and
Angélique Galvani and
Aude Espigat and
Jean Rossier Functional role of $ \epsilon $-tubulin
in the assembly of the centriolar
microtubule scaffold . . . . . . . . . . 1183
Yuhua Shang and
Bing Li and
Martin A. Gorovsky \bionameTetrahymena thermophila contains
a conventional $ \gamma $-tubulin that
is differentially required for the
maintenance of different
microtubule-organizing centers . . . . . 1195
Thomas J. Diefenbach and
Vaughan M. Latham and
Dean Yimlamai and
Canwen A. Liu and
Ira M. Herman and
Daniel G. Jay Myosin 1c and myosin IIB serve opposing
roles in lamellipodial dynamics of the
neuronal growth cone . . . . . . . . . . 1207
Gianluca Gallo and
Hal F. Yee and
Paul C. Letourneau Actin turnover is required to prevent
axon retraction driven by endogenous
actomyosin contractility . . . . . . . . 1219
Jamil Kanaani and
Alaa El-Din El-Husseini and
Andrea Aguilera-Moreno and
Julia M. Diacovo and
David S. Bredt and
Steinunn Baekkeskov A combination of three distinct
trafficking signals mediates axonal
targeting and presynaptic clustering of
GAD65 . . . . . . . . . . . . . . . . . 1229
Susan Hayes and
Anil Chawla and
Silvia Corvera TGF$ \beta $ receptor internalization
into EEA1-enriched early endosomes . . . 1239
Nina Storey and
David Latchman and
Stuart Bevan Selective internalization of sodium
channels in rat dorsal root ganglion
neurons infected with herpes simplex
virus-1 . . . . . . . . . . . . . . . . 1251
Stephen C. Bunnell and
David I. Hong and
Julia R. Kardon and
Tetsuo Yamazaki and
C. Jane McGlade and
Valarie A. Barr and
Lawrence E. Samelson T cell receptor ligation induces the
formation of dynamically regulated
signaling assemblies . . . . . . . . . . 1263
Thalia Becker and
F.-Ulrich Hartl and
Felix Wieland CD40, an extracellular receptor for
binding and uptake of Hsp70--peptide
complexes . . . . . . . . . . . . . . . 1277
Hongquan Zhang and
Zhilun Li and
Eva-Karin Viklund and
Staffan Strömblad p21-activated kinase 4 interacts with
integrin $ \alpha $v$ \beta $5 and
regulates $ \alpha $v$ \beta $5-mediated
cell migration . . . . . . . . . . . . . 1287
Alexander R. Kazarov and
Xiuwei Yang and
Christopher S. Stipp and
Bantoo Sehgal and
Martin E. Hemler An extracellular site on tetraspanin
CD151 determines $ \alpha $3 and $
\alpha $6 integrin-dependent cellular
morphology . . . . . . . . . . . . . . . 1299
Nicole LeBrasseur Calcium increases the appetite . . . . . ??
Nicole LeBrasseur Big proteins Ran into import
difficulties . . . . . . . . . . . . . . ??
Nicole LeBrasseur Everyone needs a home . . . . . . . . . ??
Nicole LeBrasseur Neutrophils choose the right direction ??
Nicole LeBrasseur A GAP in COPI vesicle formation is
filled . . . . . . . . . . . . . . . . . ??
William A. Wells Electrical healing . . . . . . . . . . . ??
William A. Wells Old and unattracted . . . . . . . . . . ??
William A. Wells Adenovirus takes the back door . . . . . ??
William A. Wells MS as a disease of immaturity . . . . . ??
William A. Wells The real role of reelin . . . . . . . . ??
Stephen C. Ogg and
Angus I. Lamond Cajal bodies and coilin --- moving
towards function . . . . . . . . . . . . 17
Amy F. Roth and
Ying Feng and
Linyi Chen and
Nicholas G. Davis The yeast DHHC cysteine-rich domain
protein Akr1p is a palmitoyl transferase 23
Caroline Pot and
Marjo Simonen and
Oliver Weinmann and
Lisa Schnell and
Franziska Christ and
Sascha Stoeckle and
Philipp Berger and
Thomas Rülicke and
Ueli Suter and
Martin E. Schwab Nogo-A expressed in Schwann cells
impairs axonal regeneration after
peripheral nerve injury . . . . . . . . 29
María C. de Marco and
Fernando Martín-Belmonte and
Leonor Kremer and
Juan P. Albar and
Isabel Correas and
Jean P. Vaerman and
Mónica Marazuela and
Jennifer A. Byrne and
Miguel A. Alonso MAL2, a novel raft protein of the MAL
family, is an essential component of the
machinery for transcytosis in hepatoma
HepG2 cells . . . . . . . . . . . . . . 37
Maki Murata-Hori and
Yu-li Wang Both midzone and astral microtubules are
involved in the delivery of cytokinesis
signals . . . . . . . . . . . . . . . . 45
Susan K. Lyman and
Tinglu Guan and
Janna Bednenko and
Harald Wodrich and
Larry Gerace Influence of cargo size on Ran and
energy requirements for nuclear protein
import . . . . . . . . . . . . . . . . . 55
Jia-Shu Yang and
Stella Y. Lee and
Minggeng Gao and
Sylvain Bourgoin and
Paul A. Randazzo and
Richard T. Premont and
Victor W. Hsu ARFGAP1 promotes the formation of COPI
vesicles, suggesting function as a
component of the coat . . . . . . . . . 69
Nicolas Vitale and
Sylvette Chasserot-Golaz and
Yannick Bailly and
Naoko Morinaga and
Michael A. Frohman and
Marie-France Bader Calcium-regulated exocytosis of
dense-core vesicles requires the
activation of ADP-ribosylation factor
(ARF)6 by ARF nucleotide binding site
opener at the plasma membrane . . . . . 79
Bryan Heit and
Samantha Tavener and
Eko Raharjo and
Paul Kubes An intracellular signaling hierarchy
determines direction of migration in
opposing chemotactic gradients . . . . . 91
Ti Cai and
Keigo Nishida and
Toshio Hirano and
Paul A. Khavari Gab1 and SHP-2 promote Ras/MAPK
regulation of epidermal growth and
differentiation . . . . . . . . . . . . 103
Bernd Martin and
Richard Schneider and
Stefanie Janetzky and
Zoe Waibler and
Petra Pandur and
Michael Kühl and
Jürgen Behrens and
Klaus von der Mark and
Anna Starzinski-Powitz and
Viktor Wixler The LIM-only protein FHL2 interacts with
$ \beta $-catenin and promotes
differentiation of mouse myoblasts . . . 113
Atsushi Asakura and
Patrick Seale and
Adele Girgis-Gabardo and
Michael A. Rudnicki Myogenic specification of side
population cells in skeletal muscle . . 123
Jeremy Skillington and
Lisa Choy and
Rik Derynck Bone morphogenetic protein and retinoic
acid signaling cooperate to induce
osteoblast differentiation of
preadipocytes . . . . . . . . . . . . . 135
Toru Akune and
Naoshi Ogata and
Kazuto Hoshi and
Naoto Kubota and
Yasuo Terauchi and
Kazuyuki Tobe and
Hideko Takagi and
Yoshiaki Azuma and
Takashi Kadowaki and
Kozo Nakamura and
Hiroshi Kawaguchi Insulin receptor substrate-2 maintains
predominance of anabolic function over
catabolic function of osteoblasts . . . 147
H. Peterziel and
K. Unsicker and
K. Krieglstein TGF$ \beta $ induces GDNF responsiveness
in neurons by recruitment of GFR$ \alpha
$1 to the plasma membrane . . . . . . . 157
Won-Jing Wang and
Jean-Cheng Kuo and
Chung-Chen Yao and
Ruey-Hwa Chen DAP-kinase induces apoptosis by
suppressing integrin activity and
disrupting matrix survival signals . . . 169
Sharon Dewitt and
Maurice B. Hallett Cytosolic free Ca$^{2+}$ changes and
calpain activation are required for $
\beta $ integrin--accelerated
phagocytosis by human neutrophils . . . 181
Alan W. Dove A motor for neurofilaments . . . . . . . ??
Alan W. Dove Initiate then elongate . . . . . . . . . ??
Alan W. Dove Building the pore . . . . . . . . . . . ??
Alan W. Dove Chromosomal cliques . . . . . . . . . . ??
Alan W. Dove Gazing into the gap . . . . . . . . . . ??
Nicole LeBrasseur Choose a side . . . . . . . . . . . . . ??
Nicole LeBrasseur Little PIP, little PIP, let me in . . . ??
Nicole LeBrasseur Branching out requires VEGF . . . . . . ??
Nicole LeBrasseur An amidation a day keeps apoptosis away ??
Nicole LeBrasseur Arrested cells are Mad as Hec . . . . . ??
Roy L. Silverstein The face of TSR revealed . . . . . . . . 203
Billy Tsai and
Tom A. Rapoport Unfolded cholera toxin is transferred to
the ER membrane and released from
protein disulfide isomerase upon
oxidation by Ero1 . . . . . . . . . . . 207
Anja Jaeschke and
Joerg Hartkamp and
Masao Saitoh and
Wendy Roworth and
Takahiro Nobukuni and
Angela Hodges and
Julian Sampson and
George Thomas and
Richard Lamb Tuberous sclerosis complex tumor
suppressor--mediated S6 kinase
inhibition by phosphatidylinositide-3-OH
kinase is mTOR independent . . . . . . . 217
Julie M. Claycomb and
David M. MacAlpine and
James G. Evans and
Stephen P. Bell and
Terry L. Orr-Weaver Visualization of replication initiation
and elongation in \bionameDrosophila . . 225
Michael N. Cornforth and
Karin M. Greulich-Bode and
Bradford D. Loucas and
Javier Arsuaga and
Mariel Vázquez and
Rainer K. Sachs and
Martina Brückner and
Michael Molls and
Philip Hahnfeldt and
Lynn Hlatky and
David J. Brenner Chromosomes are predominantly located
randomly with respect to each other in
interphase human cells . . . . . . . . . 237
Nicholas J. Quintyne and
Trina A. Schroer Distinct cell cycle-dependent roles for
dynactin and dynein at centrosomes . . . 245
Alexander Dammermann and
Andreas Merdes Assembly of centrosomal proteins and
microtubule organization depends on
PCM-1 . . . . . . . . . . . . . . . . . 255
C. Patrick Lusk and
Taras Makhnevych and
Marcello Marelli and
John D. Aitchison and
Richard W. Wozniak Karyopherins in nuclear pore biogenesis 267
Mala V. Rao and
Linda J. Engle and
Panaiyur S. Mohan and
Aidong Yuan and
Dike Qiu and
Anne Cataldo and
Linda Hassinger and
Stephen Jacobsen and
Virginia M-Y. Lee and
Athena Andreadis and
Jean-Pierre Julien and
Paul C. Bridgman and
Ralph A. Nixon Myosin Va binding to neurofilaments is
essential for correct myosin Va
distribution and transport and
neurofilament density . . . . . . . . . 279
Johannes C. Lenz and
H. Peter Reusch and
Nadine Albrecht and
Günter Schultz and
Michael Schaefer Ca$^{2+}$-controlled competitive
diacylglycerol binding of protein kinase
C isoenzymes in living cells . . . . . . 291
Yves Heremans and
Mark Van De Casteele and
Peter in't Veld and
Gerard Gradwohl and
Palle Serup and
Ole Madsen and
Daniel Pipeleers and
Harry Heimberg Recapitulation of embryonic
neuroendocrine differentiation in adult
human pancreatic duct cells expressing
neurogenin 3 . . . . . . . . . . . . . . 303
Ketu Mishra-Gorur and
Matthew D. Rand and
Beatriz Perez-Villamil and
Spyros Artavanis-Tsakonas Down-regulation of Delta by proteolytic
processing . . . . . . . . . . . . . . . 313
Juan Arredondo and
Vu Thuong Nguyen and
Alexander I. Chernyavsky and
Dani Bercovich and
Avi Orr-Urtreger and
Wolfgang Kummer and
Katrin Lips and
Douglas E. Vetter and
Sergei A. Grando Central role of $ \alpha $7 nicotinic
receptor in differentiation of the
stratified squamous epithelium . . . . . 325
Maëlle Jospin and
Vincent Jacquemond and
Marie-Christine Mariol and
Laurent Ségalat and
Bruno Allard The L-type voltage-dependent Ca$^{2+}$
channel EGL-19 controls body wall muscle
function in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 337
I. M. Skerrett and
J. Aronowitz and
J. H. Shin and
G. Cymes and
E. Kasperek and
F. L. Cao and
B. J. Nicholson Identification of amino acid residues
lining the pore of a gap junction
channel . . . . . . . . . . . . . . . . 349
Sebastian Poliak and
Sean Matlis and
Christoph Ullmer and
Steven S. Scherer and
Elior Peles Distinct claudins and associated PDZ
proteins form different autotypic tight
junctions in myelinating Schwann cells 361
Kemin Tan and
Mark Duquette and
Jin-huan Liu and
Yicheng Dong and
Rongguang Zhang and
Andrzej Joachimiak and
Jack Lawler and
Jia-huai Wang Crystal structure of the TSP-1 type 1
repeats . . . . . . . . . . . . . . . . 373
Nicole LeBrasseur cGMP steers axons home . . . . . . . . . ??
Nicole LeBrasseur ECM communicates with MMP . . . . . . . ??
Nicole LeBrasseur E-Cadherin in a stabilizing relationship ??
Nicole LeBrasseur Tension seals axons fate . . . . . . . . ??
Nicole LeBrasseur Ribosomes pile up . . . . . . . . . . . ??
William A. Wells Flicking the chromosome--attachment
switch . . . . . . . . . . . . . . . . . ??
William A. Wells Repressing differentiation . . . . . . . ??
William A. Wells Switch to survival . . . . . . . . . . . ??
William A. Wells An unlikely culprit in prion diseases ??
William A. Wells Transcriptional segregation . . . . . . ??
Beate Sodeik Unchain my heart, baby let me go --- the
entry and intracellular transport of HIV 393
Svetlana Rashkova and
Sarah E. Karam and
Rebecca Kellum and
Mary-Lou Pardue Gag proteins of the two
\bionameDrosophila telomeric
retrotransposons are targeted to
chromosome ends . . . . . . . . . . . . 397
Anat A. Herskovits and
Eyal Shimoni and
Abraham Minsky and
Eitan Bibi Accumulation of endoplasmic membranes
and novel membrane-bound
ribosome--signal recognition particle
receptor complexes in
\bionameEscherichia coli . . . . . . . . 403
Joan C. Politz and
Laura B. Lewandowski and
Thoru Pederson Signal recognition particle RNA
localization within the nucleolus
differs from the classical sites of
ribosome synthesis . . . . . . . . . . . 411
Jeffrey D. Amack and
Shannon R. Reagan and
Mani S. Mahadevan Mutant DMPK 3'-UTR transcripts disrupt
C2C12 myogenic differentiation by
compromising MyoD . . . . . . . . . . . 419
Jun Yang and
Xiaoqing Liu and
Guohua Yue and
Michael Adamian and
Oleg Bulgakov and
Tiansen Li Rootletin, a novel coiled-coil protein,
is a structural component of the ciliary
rootlet . . . . . . . . . . . . . . . . 431
David McDonald and
Marie A. Vodicka and
Ginger Lucero and
Tatyana M. Svitkina and
Gary G. Borisy and
Michael Emerman and
Thomas J. Hope Visualization of the intracellular
behavior of HIV in living cells . . . . 441
Marie-Ange Deugnier and
Marisa M. Faraldo and
Bassam Janji and
Patricia Rousselle and
Jean Paul Thiery and
Marina A. Glukhova EGF controls the in vivo developmental
potential of a mammary epithelial cell
line possessing progenitor properties 453
Reneé C. Ireton and
Michael A. Davis and
Jolanda van Hengel and
Deborah J. Mariner and
Kirk Barnes and
Molly A. Thoreson and
Panos Z. Anastasiadis and
Linsey Matrisian and
Linda M. Bundy and
Linda Sealy and
Barbara Gilbert and
Frans van Roy and
Albert B. Reynolds A novel role for p120 catenin in
E-cadherin function . . . . . . . . . . 465
Henry C. Chang and
Sherri L. Newmyer and
Michael J. Hull and
Melanie Ebersold and
Sandra L. Schmid and
Ira Mellman Hsc70 is required for endocytosis and
clathrin function in \bionameDrosophila 477
Hannes Schmidt and
Matthias Werner and
Paul A. Heppenstall and
Mechthild Henning and
Margret I. Moré and
Susanne Kühbandner and
Gary R. Lewin and
Franz Hofmann and
Robert Feil and
Fritz G. Rathjen cGMP-mediated signaling via cGKI$ \alpha
$ is required for the guidance and
connectivity of sensory axons . . . . . 489
Phillip Lamoureux and
Gordon Ruthel and
Robert E. Buxbaum and
Steven R. Heidemann Mechanical tension can specify axonal
fate in hippocampal neurons . . . . . . 499
Beatriz G. Gálvez and
Salomón Matías-Román and
María Yáñez-Mó and
Francisco Sánchez-Madrid and
Alicia G. Arroyo ECM regulates MT1-MMP localization with
$ \beta $1 or $ \alpha $v$ \beta $3
integrins at distinct cell compartments
modulating its internalization and
activity on human endothelial cells . . 509
Alan W. Dove Suicide attempt linked to breakdown . . ??
Alan W. Dove CLIPs to the rescue . . . . . . . . . . ??
Alan W. Dove ER takes a faster track . . . . . . . . ??
Alan W. Dove Selecting synapse start sites . . . . . ??
Alan W. Dove A chaperone in motoneuron disease . . . ??
Nicole LeBrasseur Viva the worm . . . . . . . . . . . . . ??
Nicole LeBrasseur Polyamino acids take amyloid form . . . ??
Nicole LeBrasseur Poking a hole in mitochondria . . . . . ??
Nicole LeBrasseur Putting a cap on reinitiation . . . . . ??
Nicole LeBrasseur Dendritic cells can be self sustaining ??
Ruth A. Van Hatten and
Antonin V. Tutter and
Antonia H. Holway and
Alyssa M. Khederian and
Johannes C. Walter and
W. Matthew Michael The \bionameXenopus Xmus101 protein is
required for the recruitment of Cdc45 to
origins of DNA replication . . . . . . . 541
Jennifer G. DeLuca and
Ben Moree and
Jennifer M. Hickey and
John V. Kilmartin and
E. D. Salmon hNuf2 inhibition blocks stable
kinetochore--microtubule attachment and
induces mitotic cell death in HeLa cells 549
Yulia Ovechkina and
Michael Wagenbach and
Linda Wordeman K-loop insertion restores microtubule
depolymerizing activity of a
``neckless'' MCAK mutant . . . . . . . . 557
Heike Bömmel and
Gang Xie and
Wilfried Rossoll and
Stefan Wiese and
Sibylle Jablonka and
Thomas Boehm and
Michael Sendtner Missense mutation in the
tubulin-specific chaperone E (Tbce) gene
in the mouse mutant progressive motor
neuronopathy, a model of human
motoneuron disease . . . . . . . . . . . 563
Torsten Wöllert and
Dieter G. Weiss and
Hans-Hermann Gerdes and
Sergei A. Kuznetsov Activation of myosin V-based motility
and F-actin-dependent network formation
of endoplasmic reticulum during mitosis 571
David Gatfield and
Elisa Izaurralde REF1\slash Aly and the additional exon
junction complex proteins are
dispensable for nuclear mRNA export . . 579
Yulia A. Komarova and
Anna S. Akhmanova and
Shin-ichiro Kojima and
Niels Galjart and
Gary G. Borisy Cytoplasmic linker proteins promote
microtubule rescue in vivo . . . . . . . 589
Mahasin A. Osman and
James B. Konopka and
Richard A. Cerione Iqg1p links spatial and secretion
landmarks to polarity and cytokinesis 601
Elena Rapizzi and
Paolo Pinton and
György Szabadkai and
Mariusz R. Wieckowski and
Grégoire Vandecasteele and
Geoff Baird and
Richard A. Tuft and
Kevin E. Fogarty and
Rosario Rizzuto Recombinant expression of the
voltage-dependent anion channel enhances
the transfer of Ca$^{2+}$ microdomains
to mitochondria . . . . . . . . . . . . 613
Jyoti K. Jaiswal and
Norma W. Andrews and
Sanford M. Simon Membrane proximal lysosomes are the
major vesicles responsible for
calcium-dependent exocytosis in
nonsecretory cells . . . . . . . . . . . 625
Raymond Chiu and
Leonid Novikov and
Shaeri Mukherjee and
Dennis Shields A caspase cleavage fragment of p115
induces fragmentation of the Golgi
apparatus and apoptosis . . . . . . . . 637
Vladimir Sytnyk and
Iryna Leshchyns'ka and
Markus Delling and
Galina Dityateva and
Alexander Dityatev and
Melitta Schachner Neural cell adhesion molecule promotes
accumulation of TGN organelles at sites
of neuron-to-neuron contacts . . . . . . 649
Matthew N. Rasband and
Eunice W. Park and
Dongkai Zhen and
Margaret I. Arbuckle and
Sebastian Poliak and
Elior Peles and
Seth G. N. Grant and
James S. Trimmer Clustering of neuronal potassium
channels is independent of their
interaction with PSD-95 . . . . . . . . 663
Asako Tsubouchi and
Junko Sakakura and
Ryohei Yagi and
Yuichi Mazaki and
Erik Schaefer and
Hajime Yano and
Hisataka Sabe Localized suppression of RhoA activity
by Tyr31/$ 118$-phosphorylated paxillin
in cell adhesion and migration . . . . . 673
Fang-Ming Deng and
Feng-Xia Liang and
Liyu Tu and
Katheryn A. Resing and
Ping Hu and
Mark Supino and
Chih-Chi Andrew Hu and
Ge Zhou and
Mingxiao Ding and
Gert Kreibich and
Tung-Tien Sun Uroplakin IIIb, a urothelial
differentiation marker, dimerizes with
uroplakin Ib as an early step of
urothelial plaque assembly . . . . . . . 685
Catherine G. Galbraith and
Kenneth M. Yamada and
Michael P. Sheetz The relationship between force and focal
complex development . . . . . . . . . . 695
Nicole LeBrasseur Build actin at the right place, right
time . . . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Mads at the nuclear pore . . . . . . . . ??
Nicole LeBrasseur Nuclear travel costs energy . . . . . . ??
Nicole LeBrasseur Sequences specify centromeric chromatin ??
Nicole LeBrasseur Microtubules get early release . . . . . ??
William A. Wells When more is not more . . . . . . . . . ??
William A. Wells Cells spin into view . . . . . . . . . . ??
William A. Wells Redox regulation . . . . . . . . . . . . ??
William A. Wells An exit strategy for the clean-up crew ??
William A. Wells 14-3-3, set me free . . . . . . . . . . ??
Miguel Abal and
Matthieu Piel and
Veronique Bouckson-Castaing and
Mette Mogensen and
Jean-Baptiste Sibarita and
Michel Bornens Microtubule release from the centrosome
in migrating cells . . . . . . . . . . . 731
Stuart H. Read and
Belinda C. Baliga and
Paul G. Ekert and
David L. Vaux and
Sharad Kumar A novel Apaf-1--independent putative
caspase-2 activation complex . . . . . . 739
Claudio Rivera and
Hong Li and
Judith Thomas-Crusells and
Hannele Lahtinen and
Tero Viitanen and
Avtandil Nanobashvili and
Zaal Kokaia and
Matti S. Airaksinen and
Juha Voipio and
Kai Kaila and
Mart Saarma BDNF-induced TrkB activation
down-regulates the K$^+$ -Cl$^{} - $
cotransporter KCC2 and impairs neuronal
Cl$^{} - $ extrusion . . . . . . . . . . 747
Nicola L. Mahy and
Paul E. Perry and
Wendy A. Bickmore Gene density and transcription influence
the localization of chromatin outside of
chromosome territories detectable by
FISH . . . . . . . . . . . . . . . . . . 753
Jun-ichirou Ohzeki and
Megumi Nakano and
Teruaki Okada and
Hiroshi Masumoto CENP-B box is required for de novo
centromere chromatin assembly on human
alphoid DNA . . . . . . . . . . . . . . 765
Hiroshi Kimura and
Kimihiko Sugaya and
Peter R. Cook The transcription cycle of RNA
polymerase II in living cells . . . . . 777
R. Ileng Kumaran and
Bhattiprolu Muralikrishna and
Veena K. Parnaik Lamin A/C speckles mediate spatial
organization of splicing factor
compartments and RNA polymerase II
transcription . . . . . . . . . . . . . 783
Alexandre Calapez and
Henrique M. Pereira and
Angelo Calado and
José Braga and
José Rino and
Célia Carvalho and
João Paulo Tavanez and
Elmar Wahle and
Agostinho C. Rosa and
Maria Carmo-Fonseca The intranuclear mobility of messenger
RNA binding proteins is ATP dependent
and temperature sensitive . . . . . . . 795
Tatiana Iouk and
Oliver Kerscher and
Robert J. Scott and
Munira A. Basrai and
Richard W. Wozniak The yeast nuclear pore complex
functionally interacts with components
of the spindle assembly checkpoint . . . 807
Sun H. Kim and
Seok J. Won and
Seonghyang Sohn and
Hyuk J. Kwon and
Jee Y. Lee and
Jong H. Park and
Byoung J. Gwag Brain-derived neurotrophic factor can
act as a pronecrotic factor through
transcriptional and translational
activation of NADPH oxidase . . . . . . 821
Matthew D. Smith and
Andreas Hiltbrunner and
Felix Kessler and
Danny J. Schnell The targeting of the atToc159 preprotein
receptor to the chloroplast outer
membrane is mediated by its GTPase
domain and is regulated by GTP . . . . . 833
Jörg Bauer and
Andreas Hiltbrunner and
Petra Weibel and
Pierre-Alexandre Vidi and
Mayte Alvarez-Huerta and
Matthew D. Smith and
Danny J. Schnell and
Felix Kessler Essential role of the G-domain in
targeting of the protein import receptor
atToc159 to the chloroplast outer
membrane . . . . . . . . . . . . . . . . 845
Keiji Uchiyama and
Eija Jokitalo and
Fumi Kano and
Masayuki Murata and
Xiaodong Zhang and
Benito Canas and
Richard Newman and
Catherine Rabouille and
Darryl Pappin and
Paul Freemont and
Hisao Kondo VCIP135, a novel essential factor for
p97/p47-mediated membrane fusion, is
required for Golgi and ER assembly in
vivo . . . . . . . . . . . . . . . . . . 855
Lisette Hari and
Véronique Brault and
Maurice Kléber and
Hye-Youn Lee and
Fabian Ille and
Rainer Leimeroth and
Christian Paratore and
Ueli Suter and
Rolf Kemler and
Lukas Sommer Lineage-specific requirements of $ \beta
$-catenin in neural crest development 867
Kris A. DeMali and
Christy A. Barlow and
Keith Burridge Recruitment of the Arp2/3 complex to
vinculin . . . . . . . . . . . . . . . . 881
Katherine M. Smith and
Alban Gaultier and
Helene Cousin and
Dominique Alfandari and
Judith M. White and
Douglas W. DeSimone The cysteine-rich domain regulates ADAM
protease function in vivo . . . . . . . 893
Alan W. Dove Shining a light on growth cones . . . . ??
Alan W. Dove Making \bionameDictyostelium stick . . . ??
Alan W. Dove Arp2\slash 3 gets inhibited . . . . . . ??
Alan W. Dove How to start a motor . . . . . . . . . . ??
Alan W. Dove Using acid to find direction . . . . . . ??
Nicole LeBrasseur Vesicles slide on a synaptic body . . . ??
Nicole LeBrasseur PilT . . . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Neurons go toward the light . . . . . . ??
Nicole LeBrasseur The brightest dots in the bunch . . . . ??
Nicole LeBrasseur Vesicles that promise enlargement . . . ??
Per Malkus and
Feng Jiang and
Randy Schekman Concentrative sorting of secretory cargo
proteins into COPII-coated vesicles . . 915
Damien Arnoult and
Philippe Parone and
Jean-Claude Martinou and
Bruno Antonsson and
Jérôme Estaquier and
Jean Claude Ameisen Mitochondrial release of
apoptosis-inducing factor occurs
downstream of cytochrome c release in
response to several proapoptotic stimuli 923
Mariusz Karbowski and
Yang-Ja Lee and
Brigitte Gaume and
Seon-Yong Jeong and
Stephan Frank and
Amotz Nechushtan and
Ansgar Santel and
Margaret Fuller and
Carolyn L. Smith and
Richard J. Youle Spatial and temporal association of Bax
with mitochondrial fission sites, Drp1,
and Mfn2 during apoptosis . . . . . . . 931
Elaine C. Larsen and
Takehiko Ueyama and
Pamela M. Brannock and
Yasuhito Shirai and
Naoaki Saito and
Christer Larsson and
Daniel Loegering and
Peter B. Weber and
Michelle R. Lennartz A role for PKC-$ \epsilon $ in Fc$
\gamma $R-mediated phagocytosis by RAW
264.7 cells . . . . . . . . . . . . . . 939
Sue L. Jaspersen and
Thomas H. Giddings and
Mark Winey Mps3p is a novel component of the yeast
spindle pole body that interacts with
the yeast centrin homologue Cdc31p . . . 945
François-Michel Boisvert and
Jocelyn Côté and
Marie-Chloé Boulanger and
Patrick Cléroux and
François Bachand and
Chantal Autexier and
Stéphane Richard Symmetrical dimethylarginine methylation
is required for the localization of SMN
in Cajal bodies and pre-mRNA splicing 957
Claudia Kruse and
Andreas Jaedicke and
Joël Beaudouin and
Florian Böhl and
Dunja Ferring and
Thomas Güttler and
Jan Ellenberg and
Ralf-Peter Jansen Ribonucleoprotein-dependent localization
of the yeast class V myosin Myo4p . . . 971
Stan Burgess and
Matt Walker and
Fei Wang and
James R. Sellers and
Howard D. White and
Peter J. Knight and
John Trinick The prepower stroke conformation of
myosin V . . . . . . . . . . . . . . . . 983
Christine L. Humphries and
Heath I. Balcer and
Jessica L. D'Agostino and
Barbara Winsor and
David G. Drubin and
Georjana Barnes and
Brenda J. Andrews and
Bruce L. Goode Direct regulation of Arp2/3 complex
activity and function by the actin
binding protein coronin . . . . . . . . 993
Arthur C. Huen and
Jung K. Park and
Lisa M. Godsel and
Xuejun Chen and
Leslie J. Bannon and
Evangeline V. Amargo and
Tracie Y. Hudson and
Anne K. Mongiu and
Irene M. Leigh and
David P. Kelsell and
Barry M. Gumbiner and
Kathleen J. Green Intermediate filament--membrane
attachments function synergistically
with actin-dependent contacts to
regulate intercellular adhesive strength 1005
Sudhiranjan Gupta and
Nicole H. Purcell and
Anning Lin and
Subha Sen Activation of nuclear factor-$ \kappa $B
is necessary for myotrophin-induced
cardiac hypertrophy . . . . . . . . . . 1019
Gianluca Baldanzi and
Nicoletta Filigheddu and
Santina Cutrupi and
Filomena Catapano and
Sara Bonissoni and
Alberto Fubini and
Daniela Malan and
Germano Baj and
Riccarda Granata and
Fabio Broglio and
Mauro Papotti and
Nicola Surico and
Federico Bussolino and
Jorgen Isgaard and
Romano Deghenghi and
Fabiola Sinigaglia and
Maria Prat and
Giampiero Muccioli and
Ezio Ghigo and
Andrea Graziani Ghrelin and des-acyl ghrelin inhibit
cell death in cardiomyocytes and
endothelial cells through ERK1/2 and PI
3-kinase/AKT . . . . . . . . . . . . . . 1029
Vicki A. Sciorra and
Simon A. Rudge and
Jiyao Wang and
Stuart McLaughlin and
JoAnne Engebrecht and
Andrew J. Morris Dual role for phosphoinositides in
regulation of yeast and mammalian
phospholipase D enzymes . . . . . . . . 1039
Paul Lee and
Jie Rao and
Albert Fliss and
Emy Yang and
Stephen Garrett and
Avrom J. Caplan The Cdc37 protein kinase--binding domain
is sufficient for protein kinase
activity and cell viability . . . . . . 1051
Zhong Ma and
Keena S. Thomas and
Donna J. Webb and
Radim Moravec and
Ana Maria Salicioni and
Wendy M. Mars and
Steven L. Gonias Regulation of Rac1 activation by the low
density lipoprotein receptor--related
protein . . . . . . . . . . . . . . . . 1061
Erik H. J. Danen and
Petra Sonneveld and
Cord Brakebusch and
Reinhard Fässler and
Arnoud Sonnenberg The fibronectin-binding integrins $
\alpha $5$ \beta $1 and $ \alpha $v$
\beta $3 differentially modulate
RhoA--GTP loading, organization of cell
matrix adhesions, and fibronectin
fibrillogenesis . . . . . . . . . . . . 1071
Sheryl P. Denker and
Diane L. Barber Cell migration requires both ion
translocation and cytoskeletal anchoring
by the Na--H exchanger NHE1 . . . . . . 1087
Yoko Nakai and
Hiroyuki Kamiguchi Migration of nerve growth cones requires
detergent-resistant membranes in a
spatially defined and
substrate-dependent manner . . . . . . . 1097
Petra Fey and
Stephen Stephens and
Margaret A. Titus and
Rex L. Chisholm SadA, a novel adhesion receptor in
\bionameDictyostelium . . . . . . . . . 1109
Nicole LeBrasseur Caspases chew on electron transport . . ??
Nicole LeBrasseur Rafts and the evil amyloids . . . . . . ??
Nicole LeBrasseur The complex life of a GEF . . . . . . . ??
Nicole LeBrasseur FRET-ing over scaffolds . . . . . . . . ??
Nicole LeBrasseur RNA travels with ZBP1 . . . . . . . . . ??
William A. Wells The importance of catastrophe . . . . . ??
William A. Wells Tubes go apical . . . . . . . . . . . . ??
William A. Wells Cohesin resolves to let go . . . . . . . ??
William A. Wells Oscillating wildly . . . . . . . . . . . ??
William A. Wells A trigger for myelination . . . . . . . ??
Alpha S. Yap and
Eva M. Kovacs Direct cadherin-activated cell signaling 11
Metello Innocenti and
Emanuela Frittoli and
Isabella Ponzanelli and
John R. Falck and
Saskia M. Brachmann and
Pier Paolo Di Fiore and
Giorgio Scita Phosphoinositide $3$-kinase activates
Rac by entering in a complex with Eps8,
Abi1, and Sos-1 . . . . . . . . . . . . 17
Gohta Goshima and
Tomomi Kiyomitsu and
Kinya Yoda and
Mitsuhiro Yanagida Human centromere chromatin protein
hMis12, essential for equal segregation,
is independent of CENP--A loading
pathway . . . . . . . . . . . . . . . . 25
Umrao R. Monani and
Matthew T. Pastore and
Tatiana O. Gavrilina and
Sibylle Jablonka and
Thanh T. Le and
Catia Andreassi and
Jennifer M. DiCocco and
Christian Lorson and
Elliot J. Androphy and
Michael Sendtner and
Michael Podell and
Arthur H. M. Burghes A transgene carrying an A2G missense
mutation in the SMN gene modulates
phenotypic severity in mice with severe
(type I) spinal muscular atrophy . . . . 41
Thomas Kaufmann and
Sarah Schlipf and
Javier Sanz and
Karin Neubert and
Reuven Stein and
Christoph Borner Characterization of the signal that
directs Bcl-x$_L$, but not Bcl-2, to the
mitochondrial outer membrane . . . . . . 53
Jean-Ehrland Ricci and
Roberta A. Gottlieb and
Douglas R. Green Caspase-mediated loss of mitochondrial
function and generation of reactive
oxygen species during apoptosis . . . . 65
Kim L. Farina and
Stefan Hüttelmaier and
Kiran Musunuru and
Robert Darnell and
Robert H. Singer Two ZBP1 KH domains facilitate $ \beta
$-actin mRNA localization, granule
formation, and cytoskeletal attachment 77
Carsten Brock and
Michael Schaefer and
H. Peter Reusch and
Cornelia Czupalla and
Manuela Michalke and
Karsten Spicher and
Günter Schultz and
Bernd Nürnberg Roles of G$ \beta \gamma $ in membrane
recruitment and activation of p110$
\gamma $ /p101 phosphoinositide
$3$-kinase $ \gamma $ . . . . . . . . . 89
Seth F. Oliveria and
Lisa L. Gomez and
Mark L. Dell'Acqua Imaging kinase--AKAP79--phosphatase
scaffold complexes at the plasma
membrane in living cells using FRET
microscopy . . . . . . . . . . . . . . . 101
Robert Ehehalt and
Patrick Keller and
Christian Haass and
Christoph Thiele and
Kai Simons Amyloidogenic processing of the
Alzheimer $ \beta $-amyloid precursor
protein depends on lipid rafts . . . . . 113
Natsuko Tanimura and
Masakazu Nagafuku and
Yasuko Minaki and
Yukio Umeda and
Fumie Hayashi and
Junko Sakakura and
Akiko Kato and
Douglas R. Liddicoat and
Masato Ogata and
Toshiyuki Hamaoka and
Atsushi Kosugi Dynamic changes in the mobility of LAT
in aggregated lipid rafts upon T cell
activation . . . . . . . . . . . . . . . 125
Li Zeng and
Xiaoning Si and
Wei-Ping Yu and
Hoa Thi Le and
Kwok Peng Ng and
Raymond M. H. Teng and
Kenneth Ryan and
Dennis Z.-M. Wang and
Sathivel Ponniah and
Catherine J. Pallen PTP$ \alpha $ regulates
integrin-stimulated FAK
autophosphorylation and cytoskeletal
rearrangement in cell spreading and
migration . . . . . . . . . . . . . . . 137
Alan W. Dove Tumor cells get primitive . . . . . . . ??
Alan W. Dove Venus dye trap catches executioners . . ??
Alan W. Dove Taking close-ups of a rafting trip . . . ??
Alan W. Dove Rejection and killing, without MPR . . . ??
Alan W. Dove An interaction that gets things started ??
Gillian M. Griffiths Endocytosing the death sentence . . . . 155
Lianwu Fu and
Elizabeth Sztul Traffic-independent function of the
Sar1p/COPII machinery in proteasomal
sorting of the cystic fibrosis
transmembrane conductance regulator . . 157
Ian A. Prior and
Cornelia Muncke and
Robert G. Parton and
John F. Hancock Direct visualization of Ras proteins in
spatially distinct cell surface
microdomains . . . . . . . . . . . . . . 165
Doris Martin and
Marianne Brown-Luedi and
Ruth Chiquet-Ehrismann Tenascin-C signaling through induction
of 14-3-3 tau . . . . . . . . . . . . . 171
Sandra Martins and
Sissel Eikvar and
Kazuhiro Furukawa and
Philippe Collas HA95 and LAP2$ \beta $ mediate a novel
chromatin--nuclear envelope interaction
implicated in initiation of DNA
replication . . . . . . . . . . . . . . 177
Hsiuchen Chen and
Scott A. Detmer and
Andrew J. Ewald and
Erik E. Griffin and
Scott E. Fraser and
David C. Chan Mitofusins Mfn1 and Mfn2 coordinately
regulate mitochondrial fusion and are
essential for embryonic development . . 189
Aipo Diao and
Dinah Rahman and
Darryl J. C. Pappin and
John Lucocq and
Martin Lowe The coiled-coil membrane protein
golgin-84 is a novel rab effector
required for Golgi ribbon formation . . 201
Ian G. Mills and
Gerrit J. K. Praefcke and
Yvonne Vallis and
Brian J. Peter and
Lene E. Olesen and
Jennifer L. Gallop and
P. Jonathan G. Butler and
Philip R. Evans and
Harvey T. McMahon EpsinR . . . . . . . . . . . . . . . . . 213
Joseph A. Trapani and
Vivien R. Sutton and
Kevin Y. T. Thia and
Yu Qin Li and
Christopher J. Froelich and
David A. Jans and
Mauro S. Sandrin and
Kylie A. Browne A clathrin/dynamin- and
mannose-$6$-phosphate
receptor--independent pathway for
granzyme B--induced cell death . . . . . 223
Kiwamu Takemoto and
Takeharu Nagai and
Atsushi Miyawaki and
Masayuki Miura Spatio-temporal activation of caspase
revealed by indicator that is
insensitive to environmental effects . . 235
Paola Bagnato and
Virigina Barone and
Emiliana Giacomello and
Daniela Rossi and
Vincenzo Sorrentino Binding of an ankyrin-1 isoform to
obscurin suggests a molecular link
between the sarcoplasmic reticulum and
myofibrils in striated muscles . . . . . 245
Amy Shaub Maddox and
Keith Burridge RhoA is required for cortical retraction
and rigidity during mitotic cell
rounding . . . . . . . . . . . . . . . . 255
Katarina Wolf and
Irina Mazo and
Harry Leung and
Katharina Engelke and
Ulrich H. von Andrian and
Elena I. Deryugina and
Alex Y. Strongin and
Eva-B. Bröcker and
Peter Friedl Compensation mechanism in tumor cell
migration . . . . . . . . . . . . . . . 267
Alan W. Dove Two motors, one transmission . . . . . . ??
Alan W. Dove A model of missegregation . . . . . . . ??
Alan W. Dove Multimembrane fusion . . . . . . . . . . ??
Alan W. Dove Urge to merge erects filopodia . . . . . ??
Alan W. Dove Anthrax toxin takes charge . . . . . . . ??
William A. Wells Is Botryllus a natural killer? . . . . . ??
William A. Wells Bacterial aging . . . . . . . . . . . . ??
William A. Wells Replicating dominos . . . . . . . . . . ??
William A. Wells Hearts grow with the flow . . . . . . . ??
William A. Wells Poised to migrate . . . . . . . . . . . ??
Xin Xiang LIS1 at the microtubule plus end and its
role in dynein-mediated nuclear
migration . . . . . . . . . . . . . . . 289
Karen R. Dell Dynactin polices two-way organelle
traffic . . . . . . . . . . . . . . . . 291
Teymuras Kurzchalia Anthrax toxin rafts into cells . . . . . 295
Sean W. Deacon and
Anna S. Serpinskaya and
Patricia S. Vaughan and
Monica Lopez Fanarraga and
Isabelle Vernos and
Kevin T. Vaughan and
Vladimir I. Gelfand Dynactin is required for bidirectional
organelle transport . . . . . . . . . . 297
Edith D. Wong and
Jennifer A. Wagner and
Sidney V. Scott and
Voytek Okreglak and
Timothy J. Holewinske and
Ann Cassidy-Stone and
Jodi Nunnari The intramitochondrial dynamin-related
GTPase, Mgm1p, is a component of a
protein complex that mediates
mitochondrial fusion . . . . . . . . . . 303
Anne Pacquelet and
Li Lin and
Pernille Ròrth Binding site for p120/$ \delta $-catenin
is not required for \bionameDrosophila
E-cadherin function in vivo . . . . . . 313
Laurence Abrami and
Shihui Liu and
Pierre Cosson and
Stephen H. Leppla and
F. Gisou van der Goot Anthrax toxin triggers endocytosis of
its receptor via a lipid raft--mediated
clathrin-dependent process . . . . . . . 321
Stéphanie Buvelot and
Sean Y. Tatsutani and
Danielle Vermaak and
Sue Biggins The budding yeast Ipl1/Aurora protein
kinase regulates mitotic spindle
disassembly . . . . . . . . . . . . . . 329
J. Ramesh Babu and
Karthik B. Jeganathan and
Darren J. Baker and
Xiaosheng Wu and
Ningling Kang-Decker and
Jan M. van Deursen Rae1 is an essential mitotic checkpoint
regulator that cooperates with Bub3 to
prevent chromosome missegregation . . . 341
Wei-Lih Lee and
Jessica R. Oberle and
John A. Cooper The role of the lissencephaly protein
Pac1 during nuclear migration in budding
yeast . . . . . . . . . . . . . . . . . 355
Li Wang and
Alexey J. Merz and
Kevin M. Collins and
William Wickner Hierarchy of protein assembly at the
vertex ring domain for yeast vacuole
docking and fusion . . . . . . . . . . . 365
Supriya Srinivasan and
Fei Wang and
Suzana Glavas and
Alexander Ott and
Fred Hofmann and
Klaus Aktories and
Daniel Kalman and
Henry R. Bourne Rac and Cdc42 play distinct roles in
regulating PI(3,4,5)P$_3$ and polarity
during neutrophil chemotaxis . . . . . . 375
Sebastian Wiesner and
Emmanuele Helfer and
Dominique Didry and
Guylaine Ducouret and
Françoise Lafuma and
Marie-France Carlier and
Dominique Pantaloni A biomimetic motility assay provides
insight into the mechanism of
actin-based motility . . . . . . . . . . 387
Raymond S. Maul and
Yuhong Song and
Kurt J. Amann and
Sachi C. Gerbin and
Thomas D. Pollard and
David D. Chang EPLIN regulates actin dynamics by
cross-linking and stabilizing filaments 399
Tatyana M. Svitkina and
Elena A. Bulanova and
Oleg Y. Chaga and
Danijela M. Vignjevic and
Shin-ichiro Kojima and
Jury M. Vasiliev and
Gary G. Borisy Mechanism of filopodia initiation by
reorganization of a dendritic network 409
Maria S. Balda and
Michelle D. Garrett and
Karl Matter The ZO-1--associated Y-box factor ZONAB
regulates epithelial cell proliferation
and cell density . . . . . . . . . . . . 423
Steven H. Myster and
Robert Cavallo and
Charles T. Anderson and
Donald T. Fox and
Mark Peifer Drosophila p120catenin plays a
supporting role in cell adhesion but is
not an essential adherens junction
component . . . . . . . . . . . . . . . 433
Alan W. Dove Sticky cells in a prickly system . . . . ??
Alan W. Dove TRAP builds a better translocon . . . . ??
Alan W. Dove This is your neuron on cannabinoids . . ??
Alan W. Dove Cajal compartments . . . . . . . . . . . ??
Alan W. Dove Four channels, but only one program . . ??
Nicole LeBrasseur Hox signals death for neuronal
precursors . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Rec'd and repaired . . . . . . . . . . . ??
Nicole LeBrasseur Promoting passage in plasmodesmata . . . ??
Nicole LeBrasseur Keeping wing cells in line . . . . . . . ??
Nicole LeBrasseur A minus-end motor sees the plus side . . ??
William A. Wells and
Nicole LeBrasseur Stories of Cells . . . . . . . . . . . . 466
S. Papp and
E. Dziak and
M. Michalak and
M. Opas Is all of the endoplasmic reticulum
created equal? The effects of the
heterogeneous distribution of
endoplasmic reticulum Ca$^{2+}$-handling
proteins . . . . . . . . . . . . . . . . 475
Emma-Jane Williams and
Frank S. Walsh and
Patrick Doherty The FGF receptor uses the
endocannabinoid signaling system to
couple to an axonal growth response . . 481
Savithri Rangarajan and
Jorrit M. Enserink and
H. Bea Kuiperij and
Johan de Rooij and
Leo S. Price and
Frank Schwede and
Johannes L. Bos Cyclic AMP induces integrin-mediated
cell adhesion through Epac and Rap1 upon
stimulation of the $ \beta_2
$-adrenergic receptor . . . . . . . . . 487
Korie E. Handwerger and
Christine Murphy and
Joseph G. Gall Steady-state dynamics of Cajal body
components in the \bionameXenopus
germinal vesicle . . . . . . . . . . . . 495
David Stan\uek and
Stephen D. Rader and
Mirko Klingauf and
Karla M. Neugebauer Targeting of U4/U6 small nuclear RNP
assembly factor SART3/p110 to Cajal
bodies . . . . . . . . . . . . . . . . . 505
Scott C. Schuyler and
Jenny Y. Liu and
David Pellman The molecular function of Ase1p . . . . 517
Ryen D. Fons and
Brigitte A. Bogert and
Ramanujan S. Hegde Substrate-specific function of the
translocon-associated protein complex
during translocation across the ER
membrane . . . . . . . . . . . . . . . . 529
Enrico Schleiff and
Jürgen Soll and
Michael Küchler and
Werner Kühlbrandt and
Roswitha Harrer Characterization of the translocon of
the outer envelope of chloroplasts . . . 541
Marlies Messerschmitt and
Stefan Jakobs and
Frank Vogel and
Stefan Fritz and
Kai Stefan Dimmer and
Walter Neupert and
Benedikt Westermann The inner membrane protein Mdm33
controls mitochondrial morphology in
yeast . . . . . . . . . . . . . . . . . 553
Qiang Wang and
Yi Xie and
Quan-Sheng Du and
Xiao-Jun Wu and
Xu Feng and
Lin Mei and
Jay M. McDonald and
Wen-Cheng Xiong Regulation of the formation of
osteoclastic actin rings by proline-rich
tyrosine kinase 2 interacting with
gelsolin . . . . . . . . . . . . . . . . 565
Murray C. H. Clarke and
John Savill and
David B. Jones and
Brendon S. Noble and
Simon B. Brown Compartmentalized megakaryocyte death
generates functional platelets committed
to caspase-independent death . . . . . . 577
Richard D. Evans and
Vivienne C. Perkins and
Alistair Henry and
Paul E. Stephens and
Martyn K. Robinson and
Fiona M. Watt A tumor-associated $ \beta $1 integrin
mutation that abrogates epithelial
differentiation control . . . . . . . . 589
Brian J. Hillier and
Victor D. Vacquier Amassin, an olfactomedin protein,
mediates the massive intercellular
adhesion of sea urchin coelomocytes . . 597
Josephine M. Enciso and
Dita Gratzinger and
Todd D. Camenisch and
Sandra Canosa and
Emese Pinter and
Joseph A. Madri Elevated glucose inhibits
VEGF--A-mediated endocardial cushion
formation . . . . . . . . . . . . . . . 605
Nicole LeBrasseur The other side of kinetochore fibers . . ??
Nicole LeBrasseur Phosphorylation cycles on vesicles . . . ??
Nicole LeBrasseur PDE5 says NO to cGMP . . . . . . . . . . ??
Nicole LeBrasseur A protease inhibitor unsticks cells . . ??
Nicole LeBrasseur Ran sticks a GEF to chromatin . . . . . ??
William A. Wells Heterochromatingets dynamic . . . . . . ??
William A. Wells Life on a bed of needles . . . . . . . . ??
William A. Wells Polarity feeds back . . . . . . . . . . ??
William A. Wells Linking spindle to furrow . . . . . . . ??
William A. Wells Exocytosis in action . . . . . . . . . . ??
Rajesh Babu Sekar and
Ammasi Periasamy Fluorescence resonance energy transfer
(FRET) microscopy imaging of live cell
protein localizations . . . . . . . . . 629
Hoi Yeung Li and
Denis Wirtz and
Yixian Zheng A mechanism of coupling RCC1 mobility to
RanGTP production on the chromatin in
vivo . . . . . . . . . . . . . . . . . . 635
Olivier Cuvier and
Tatsuya Hirano A role of topoisomerase II in linking
DNA replication to chromosome
condensation . . . . . . . . . . . . . . 645
Maureen Eijpe and
Hildo Offenberg and
Rolf Jessberger and
Ekaterina Revenkova and
Christa Heyting Meiotic cohesin REC8 marks the axial
elements of rat synaptonemal complexes
before cohesins SMC1$ \beta $ and SMC3 657
Alexey Khodjakov and
Lily Copenagle and
Michael B. Gordon and
Duane A. Compton and
Tarun M. Kapoor Minus-end capture of preformed
kinetochore fibers contributes to
spindle morphogenesis . . . . . . . . . 671
Joachim Walter and
Lothar Schermelleh and
Marion Cremer and
Satoshi Tashiro and
Thomas Cremer Chromosome order in HeLa cells changes
during mitosis and early G1, but is
stably maintained during subsequent
interphase stages . . . . . . . . . . . 685
Pradipta Ghosh and
Stuart Kornfeld AP-1 binding to sorting signals and
release from clathrin-coated vesicles is
regulated by phosphorylation . . . . . . 699
Tsuyoshi Miyazaki and
Lynn Neff and
Sakae Tanaka and
William C. Horne and
Roland Baron Regulation of cytochrome c oxidase
activity by c--Src in osteoclasts . . . 709
Florian Mullershausen and
Andreas Friebe and
Robert Feil and
W. Joseph Thompson and
Franz Hofmann and
Doris Koesling Direct activation of PDE5 by cGMP . . . 719
Gaëlle Benais-Pont and
Anu Punn and
Catalina Flores-Maldonado and
Judith Eckert and
Graça Raposo and
Tom P. Fleming and
Marcelino Cereijido and
Maria S. Balda and
Karl Matter Identification of a tight
junction--associated guanine nucleotide
exchange factor that activates Rho and
regulates paracellular permeability . . 729
R. Mark Grady and
Mohammed Akaaboune and
Alexander L. Cohen and
Margaret M. Maimone and
Jeff W. Lichtman and
Joshua R. Sanes Tyrosine-phosphorylated and
nonphosphorylated isoforms of $ \alpha
$-dystrobrevin . . . . . . . . . . . . . 741
Datsun A. Hsia and
Satyajit K. Mitra and
Christof R. Hauck and
Daniel N. Streblow and
Jay A. Nelson and
Dusko Ilic and
Shuang Huang and
Erguang Li and
Glen R. Nemerow and
Jay Leng and
Kathryn S. R. Spencer and
David A. Cheresh and
David D. Schlaepfer Differential regulation of cell motility
and invasion by FAK . . . . . . . . . . 753
Osamu Inoue and
Katsue Suzuki-Inoue and
William L. Dean and
Jon Frampton and
Steve P. Watson Integrin $ \alpha_2 \beta_1 $ mediates
outside-in regulation of platelet
spreading on collagen through activation
of Src kinases and PLC$ \gamma $2 . . . 769
Ralf-Peter Czekay and
Kathleen Aertgeerts and
Scott A. Curriden and
David J. Loskutoff Plasminogen activator inhibitor-1
detaches cells from extracellular
matrices by inactivating integrins . . . 781
Alan W. Dove When death starts with a caspase . . . . ??
Alan W. Dove Fusion failure for flies . . . . . . . . ??
Alan W. Dove When the channels leak, the muscle is
weak . . . . . . . . . . . . . . . . . . ??
Alan W. Dove Three AMIGOs grow a brain . . . . . . . ??
Alan W. Dove Stem cells to build muscles . . . . . . ??
Nicole LeBrasseur Inducing Sprouty degradation . . . . . . ??
Nicole LeBrasseur Nucleoli come undone . . . . . . . . . . ??
Nicole LeBrasseur Nucleosomes get peeled and rewrapped . . ??
Nicole LeBrasseur Endosomes make tracks . . . . . . . . . ??
Nicole LeBrasseur Riding Kar9 into the bud . . . . . . . . ??
Darwin J. Prockop Further proof of the plasticity of adult
stem cells and their role in tissue
repair . . . . . . . . . . . . . . . . . 807
Anthony Bretscher Polarized growth and organelle
segregation in yeast . . . . . . . . . . 811
Anthony Brown Axonal transport of membranous and
nonmembranous cargoes . . . . . . . . . 817
Hél\`ene Tourri\`ere and
Karim Chebli and
Latifa Zekri and
Brice Courselaud and
Jean Marie Blanchard and
Edouard Bertrand and
Jamal Tazi The RasGAP-associated endoribonuclease
G3BP assembles stress granules . . . . . 823
Karthikeyan Mythreye and
Kerry S. Bloom Differential kinetochore protein
requirements for establishment versus
propagation of centromere activity in
\bionameSaccharomyces cerevisiae . . . . 833
Meng-Fu Bryan Tsou and
Wei Ku and
Adam Hayashi and
Lesilee S. Rose PAR-dependent and geometry-dependent
mechanisms of spindle positioning . . . 845
Elena Chiroli and
Roberta Fraschini and
Alessia Beretta and
Mariagrazia Tonelli and
Giovanna Lucchini and
Simonetta Piatti Budding yeast PAK kinases regulate
mitotic exit by two different mechanisms 857
Sunil S. Metkar and
Baikun Wang and
Michelle L. Ebbs and
Jin H. Kim and
Yong J. Lee and
Srikumar M. Raja and
Christopher J. Froelich Granzyme B activates procaspase-3 which
signals a mitochondrial amplification
loop for maximal apoptosis . . . . . . . 875
Kuniko Ishikawa and
Natalie L. Catlett and
Jennifer L. Novak and
Fusheng Tang and
Johnathan J. Nau and
Lois S. Weisman Identification of an organelle-specific
myosin V receptor . . . . . . . . . . . 887
Hongjun Liu and
Michelle Mardahl-Dumesnil and
Sean T. Sweeney and
Cahir J. O'Kane and
Sanford I. Bernstein Drosophila paramyosin is important for
myoblast fusion and essential for
myofibril formation . . . . . . . . . . 899
Cosimo De Bari and
Francesco Dell'Accio and
Frank Vandenabeele and
Joris R. Vermeesch and
Jean-Marc Raymackers and
Frank P. Luyten Skeletal muscle repair by adult human
mesenchymal stem cells from synovial
membrane . . . . . . . . . . . . . . . . 909
Steven Reiken and
Alain Lacampagne and
Hua Zhou and
Aftab Kherani and
Stephan E. Lehnart and
Chris Ward and
Fannie Huang and
Marta Gaburjakova and
Jana Gaburjakova and
Nora Rosemblit and
Michelle S. Warren and
Kun-lun He and
Geng-hua Yi and
Jie Wang and
Daniel Burkhoff and
Guy Vassort and
Andrew R. Marks PKA phosphorylation activates the
calcium release channel (ryanodine
receptor) in skeletal muscle . . . . . . 919
Bai Luo and
Stephen M. Prescott and
Matthew K. Topham Association of diacylglycerol kinase $
\zeta $ with protein kinase C $ \alpha $ 929
Janice Robertson and
Mohammad M. Doroudchi and
Minh Dang Nguyen and
Heather D. Durham and
Michael J. Strong and
Gerry Shaw and
Jean-Pierre Julien and
Walter E. Mushynski A neurotoxic peripherin splice variant
in a mouse model of ALS . . . . . . . . 939
Danijela Vignjevic and
Defne Yarar and
Matthew D. Welch and
John Peloquin and
Tatyana Svitkina and
Gary G. Borisy Formation of filopodia-like bundles in
vitro from a dendritic network . . . . . 951
Juha Kuja-Panula and
Marjaana Kiiltomäki and
Takashi Yamashiro and
Ari Rouhiainen and
Heikki Rauvala AMIGO, a transmembrane protein
implicated in axon tract development,
defines a novel protein family with
leucine-rich repeats . . . . . . . . . . 963
Nicole LeBrasseur Building and breaking the NPC . . . . . ??
Nicole LeBrasseur Calcium for strong clotting . . . . . . ??
Nicole LeBrasseur Deacetylase undoes DNA damage . . . . . ??
Nicole LeBrasseur DNA-free division . . . . . . . . . . . ??
Nicole LeBrasseur Mitochondria sensitive to ER Ca$^{2+}$
stores . . . . . . . . . . . . . . . . . ??
William A. Wells A boisterous histone . . . . . . . . . . ??
William A. Wells How old mothers can have young offspring ??
William A. Wells Hide and seek . . . . . . . . . . . . . ??
William A. Wells Making stripes . . . . . . . . . . . . . ??
William A. Wells Chromosomes in the `hood . . . . . . . . ??
William A. Wells Movement in Colorado . . . . . . . . . . 985
William C. Earnshaw and
Mar Carmena A perfect funeral with no corpse . . . . 989
Emmanuel Lemichez and
Patrice Boquet To be helped or not helped, that is the
question . . . . . . . . . . . . . . . . 991
Elisabetta Bucciarelli and
Maria Grazia Giansanti and
Silvia Bonaccorsi and
Maurizio Gatti Spindle assembly and cytokinesis in the
absence of chromosomes during
\bionameDrosophila male meiosis . . . . 993
Tomohiko Fukuda and
Lida Guo and
Xiaohua Shi and
Chuanyue Wu CH-ILKBP regulates cell survival by
facilitating the membrane translocation
of protein kinase B/Akt . . . . . . . . 1001
Lars H. Engelholm and
Karin List and
Sarah Netzel-Arnett and
Edna Cukierman and
David J. Mitola and
Hannah Aaronson and
Lars Kjòller and
Jòrgen K. Larsen and
Kenneth M. Yamada and
Dudley K. Strickland and
Kenn Holmbeck and
Keld Danò and
Henning Birkedal-Hansen and
Niels Behrendt and
Thomas H. Bugge uPARAP\slash Endo180 is essential for
cellular uptake of collagen and promotes
fibroblast collagen adhesion . . . . . . 1009
Gary D. Kao and
W. Gillies McKenna and
Matthew G. Guenther and
Ruth J. Muschel and
Mitchell A. Lazar and
Tim J. Yen Histone deacetylase 4 interacts with
53BP1 to mediate the DNA damage response 1017
Frederic Kendirgi and
Dianne M. Barry and
Eric R. Griffis and
Maureen A. Powers and
Susan R. Wente An essential role for hGle1
nucleocytoplasmic shuttling in mRNA
export . . . . . . . . . . . . . . . . . 1029
Kathryn J. Ryan and
J. Michael McCaffery and
Susan R. Wente The Ran GTPase cycle is required for
yeast nuclear pore complex assembly . . 1041
Péter Lénárt and
Gwénaël Rabut and
Nathalie Daigle and
Arthur R. Hand and
Mark Terasaki and
Jan Ellenberg Nuclear envelope breakdown in starfish
oocytes proceeds by partial NPC
disassembly followed by a rapidly
spreading fenestration of nuclear
membranes . . . . . . . . . . . . . . . 1055
Shyr-Jiann Li and
Mark Hochstrasser The Ulp1 SUMO isopeptidase . . . . . . . 1069
Ana Berlin and
Anne Paoletti and
Fred Chang Mid2p stabilizes septin rings during
cytokinesis in fission yeast . . . . . . 1083
Joseph J. Tasto and
Jennifer L. Morrell and
Kathleen L. Gould An anillin homologue, Mid2p, acts during
fission yeast cytokinesis to organize
the septin ring and promote cell
separation . . . . . . . . . . . . . . . 1093
Jean-Pierre Levraud and
Myriam Adam and
Marie-Françoise Luciani and
Chantal de Chastellier and
Richard L. Blanton and
Pierre Golstein \bionameDictyostelium cell death . . . . 1105
David G. Breckenridge and
Marina Stojanovic and
Richard C. Marcellus and
Gordon C. Shore Caspase cleavage product of BAP31
induces mitochondrial fission through
endoplasmic reticulum calcium signals,
enhancing cytochrome c release to the
cytosol . . . . . . . . . . . . . . . . 1115
N. D. Sonawane and
A. S. Verkman Determinants of [Cl$^{} - $] in
recycling and late endosomes and Golgi
complex measured using fluorescent
ligands . . . . . . . . . . . . . . . . 1129
Ryan Ratts and
Huiyan Zeng and
Eric A. Berg and
Clare Blue and
Mark E. McComb and
Cathy E. Costello and
Johanna C. vanderSpek and
John R. Murphy The cytosolic entry of diphtheria toxin
catalytic domain requires a host cell
cytosolic translocation factor complex 1139
Warwick S. Nesbitt and
Simon Giuliano and
Suhasini Kulkarni and
Sacha M. Dopheide and
Ian S. Harper and
Shaun P. Jackson Intercellular calcium communication
regulates platelet aggregation and
thrombus growth . . . . . . . . . . . . 1151
Eric C. Lai RB pockets the cell cycle . . . . . . . ??
Eric C. Lai Life in a low calcium home . . . . . . . ??
Eric C. Lai APP causes an energy crisis . . . . . . ??
Eric C. Lai Where new neurons come from . . . . . . ??
Eric C. Lai Lamas in loops . . . . . . . . . . . . . ??
Nicole LeBrasseur Shaping up plants . . . . . . . . . . . ??
Nicole LeBrasseur The spindle gets the Axs . . . . . . . . ??
Nicole LeBrasseur Ring around the chromatin . . . . . . . ??
Nicole LeBrasseur Searching DNA in $3$D . . . . . . . . . ??
Nicole LeBrasseurr Dying of a bad overhang . . . . . . . . ??
Patricia Camacho Malaria parasites solve the problem of a
low calcium environment . . . . . . . . 17
Aaron F. Severson and
Bruce Bowerman Myosin and the PAR proteins polarize
microfilament-dependent forces that
shape and position mitotic spindles in
\bionameCaenorhabditis elegans . . . . . 21
Antonino Colanzi and
Christine Sutterlin and
Vivek Malhotra RAF1-activated MEK1 is found on the
Golgi apparatus in late prophase and is
required for Golgi complex fragmentation
in mitosis . . . . . . . . . . . . . . . 27
Boyan K. Garvalov and
Theresa E. Higgins and
James D. Sutherland and
Markus Zettl and
Niki Scaplehorn and
Thomas Köcher and
Eugenia Piddini and
Gareth Griffiths and
Michael Way The conformational state of Tes
regulates its zyxin-dependent
recruitment to focal adhesions . . . . . 33
Hindupur K. Anandatheerthavarada and
Gopa Biswas and
Marie-Anne Robin and
Narayan G. Avadhani Mitochondrial targeting and a novel
transmembrane arrest of Alzheimer's
amyloid precursor protein impairs
mitochondrial function in neuronal cells 41
Chun-Hong Xia and
Elizabeth A. Roberts and
Lu-Shiun Her and
Xinran Liu and
David S. Williams and
Don W. Cleveland and
Lawrence S. B. Goldstein Abnormal neurofilament transport caused
by targeted disruption of neuronal
kinesin heavy chain KIF5A . . . . . . . 55
Olivier D. Lohez and
Caroline Reynaud and
Franck Borel and
Paul R. Andreassen and
Robert L. Margolis Arrest of mammalian fibroblasts in G1 in
response to actin inhibition is
dependent on retinoblastoma pocket
proteins but not on p53 . . . . . . . . 67
Kiyoko Fukami and
Manabu Yoshida and
Takafumi Inoue and
Manabu Kurokawa and
Rafael A. Fissore and
Nobuaki Yoshida and
Katsuhiko Mikoshiba and
Tadaomi Takenawa Phospholipase C$ \delta $4 is required
for Ca$^{2+}$ mobilization essential for
acrosome reaction in sperm . . . . . . . 79
Chris D. Wood and
Alberto Darszon and
Michael Whitaker Speract induces calcium oscillations in
the sperm tail . . . . . . . . . . . . . 89
Marcos L. Gazarini and
Andrew P. Thomas and
Tullio Pozzan and
Célia R. S. Garcia Calcium signaling in a low calcium
environment . . . . . . . . . . . . . . 103
Valerie Horsley and
Grace K. Pavlath Prostaglandin F$_{2 \alpha }$ stimulates
growth of skeletal muscle cells via an
NFATC2-dependent pathway . . . . . . . . 111
Anna Popsueva and
Dmitry Poteryaev and
Elena Arighi and
Xiaojuan Meng and
Alexandre Angers-Loustau and
David Kaplan and
Mart Saarma and
Hannu Sariola GDNF promotes tubulogenesis of GFR$
\alpha $1-expressing MDCK cells by
Src-mediated phosphorylation of Met
receptor tyrosine kinase . . . . . . . . 119
Huaye Zhang and
Donna J. Webb and
Hannelore Asmussen and
Alan F. Horwitz Synapse formation is regulated by the
signaling adaptor GIT1 . . . . . . . . . 131
Götz von Wichert and
Guoying Jiang and
Ana Kostic and
Kurt De Vos and
Jan Sap and
Michael P. Sheetz RPTP-$ \alpha $ acts as a transducer of
mechanical force on $ \alpha_v \slash
\beta_3 $-integrin-cytoskeleton linkages 143
Zohreh Mostafavi-Pour and
Janet A. Askari and
Scott J. Parkinson and
Peter J. Parker and
Tony T. C. Ng and
Martin J. Humphries Integrin-specific signaling pathways
controlling focal adhesion formation and
cell migration . . . . . . . . . . . . . 155
Shibeshih Belachew and
Ramesh Chittajallu and
Adan A. Aguirre and
Xiaoqing Yuan and
Martha Kirby and
Stacie Anderson and
Vittorio Gallo Postnatal NG2 proteoglycan--expressing
progenitor cells are intrinsically
multipotent and generate functional
neurons . . . . . . . . . . . . . . . . 169
Yamato Kikkawa and
Ismo Virtanen and
Jeffrey H. Miner Mesangial cells organize the glomerular
capillaries by adhering to the G domain
of laminin $ \alpha $5 in the glomerular
basement membrane . . . . . . . . . . . 187
Susann Schenk and
Edith Hintermann and
Martin Bilban and
Naohiko Koshikawa and
Carlo Hojilla and
Rama Khokha and
Vito Quaranta Binding to EGF receptor of a laminin-5
EGF-like fragment liberated during
MMP-dependent mammary gland involution 197
Nicole LeBrasseur Aurora B puts chromosomes in their place ??
Nicole LeBrasseur To grow or to shrink \ldots . . . . . . ??
Nicole LeBrasseur H. pylori mobilizes cells . . . . . . . ??
Nicole LeBrasseur Choosing replication origins . . . . . . ??
Nicole LeBrasseur Say NO to insulin . . . . . . . . . . . ??
Rabiya S. Tuma ROS for your roots . . . . . . . . . . . ??
Rabiya S. Tuma Conserving synaptic weight . . . . . . . ??
Rabiya S. Tuma Reconstituting a chloroplast transport
system . . . . . . . . . . . . . . . . . ??
Rabiya S. Tuma Calcium waves in membrane fusion . . . . ??
Rabiya S. Tuma Toxoplasma uses tough love . . . . . . . ??
Andrea D. Weston and
Bruce Blumberg and
T. Michael Underhill Active repression by unliganded retinoid
receptors in development . . . . . . . . 223
Alper Romano and
Annika Guse and
Ivica Krascenicova and
Heinke Schnabel and
Ralf Schnabel and
Michael Glotzer Csc-1 . . . . . . . . . . . . . . . . . 229
Danny Köhler and
Christine Ruff and
Edgar Meyhöfer and
Martin Bähler Different degrees of lever arm rotation
control myosin step size . . . . . . . . 237
Mark A. Rizzo and
David W. Piston Regulation of $ \beta $ cell glucokinase
by S-nitrosylation and association with
nitric oxide synthase . . . . . . . . . 243
Yuri Churin and
Laila Al-Ghoul and
Oliver Kepp and
Thomas F. Meyer and
Walter Birchmeier and
Michael Naumann Helicobacter pylori CagA protein targets
the c--Met receptor and enhances the
motogenic response . . . . . . . . . . . 249
Feng Li and
Jianhua Chen and
Eduardo Solessio and
David M. Gilbert Spatial distribution and specification
of mammalian replication origins during
G1 phase . . . . . . . . . . . . . . . . 257
Claire Ditchfield and
Victoria L. Johnson and
Anthony Tighe and
Rebecca Ellston and
Carolyn Haworth and
Trevor Johnson and
Andrew Mortlock and
Nicholas Keen and
Stephen S. Taylor Aurora B couples chromosome alignment
with anaphase by targeting BubR1, Mad2,
and Cenp--E to kinetochores . . . . . . 267
Silke Hauf and
Richard W. Cole and
Sabrina LaTerra and
Christine Zimmer and
Gisela Schnapp and
Rainer Walter and
Armin Heckel and
Jacques van Meel and
Conly L. Rieder and
Jan-Michael Peters The small molecule Hesperadin reveals a
role for Aurora B in correcting
kinetochore--microtubule attachment and
in maintaining the spindle assembly
checkpoint . . . . . . . . . . . . . . . 281
Alison L. Pidoux and
William Richardson and
Robin C. Allshire Sim4 . . . . . . . . . . . . . . . . . . 295
Michael Doyle and
Michael F. Jantsch Distinct in vivo roles for
double-stranded RNA-binding domains of
the \bionameXenopus RNA-editing enzyme
ADAR1 in chromosomal targeting . . . . . 309
Franco J. Vizeacoumar and
Juan C. Torres-Guzman and
Yuen Yi C. Tam and
John D. Aitchison and
Richard A. Rachubinski YHR150w and YDR479c encode peroxisomal
integral membrane proteins involved in
the regulation of peroxisome number,
size, and distribution in
\bionameSaccharomyces cerevisiae . . . . 321
Esther J. Chen and
Chris A. Kaiser LST8 negatively regulates amino acid
biosynthesis as a component of the TOR
pathway . . . . . . . . . . . . . . . . 333
Mimi Shirasu-Hiza and
Peg Coughlin and
Tim Mitchison Identification of XMAP215 as a
microtubule-destabilizing factor in
\bionameXenopus egg extract by
biochemical purification . . . . . . . . 349
Mark van Breugel and
David Drechsel and
Anthony Hyman Stu2p, the budding yeast member of the
conserved Dis1/XMAP215 family of
microtubule-associated proteins is a
plus end--binding microtubule
destabilizer . . . . . . . . . . . . . . 359
Robert S. Fischer and
Kimberly L. Fritz-Six and
Velia M. Fowler Pointed-end capping by tropomodulin3
negatively regulates endothelial cell
motility . . . . . . . . . . . . . . . . 371
Yoshiki Arakawa and
Haruhiko Bito and
Tomoyuki Furuyashiki and
Takahiro Tsuji and
Sayaka Takemoto-Kimura and
Kazuhiro Kimura and
Kazuhiko Nozaki and
Nobuo Hashimoto and
Shuh Narumiya Control of axon elongation via an SDF-1$
\alpha $ /Rho/mDia pathway in cultured
cerebellar granule neurons . . . . . . . 381
David M. McKean and
Lila Sisbarro and
Dusko Ilic and
Nihal Kaplan-Alburquerque and
Raphael Nemenoff and
Mary Weiser-Evans and
Michael J. Kern and
Peter Lloyd Jones FAK induces expression of Prx1 to
promote tenascin--C-dependent fibroblast
migration . . . . . . . . . . . . . . . 393
Stefan Bonné and
Barbara Gilbert and
Mechthild Hatzfeld and
Xinyu Chen and
Kathleen J. Green and
Frans van Roy Defining desmosomal plakophilin-3
interactions . . . . . . . . . . . . . . 403
Mika Shimonaka and
Koko Katagiri and
Toshinori Nakayama and
Naoya Fujita and
Takashi Tsuruo and
Osamu Yoshie and
Tatsuo Kinashi Rap1 translates chemokine signals to
integrin activation, cell polarization,
and motility across vascular endothelium
under flow . . . . . . . . . . . . . . . 417
Beata Wojciak-Stothard and
Anne J. Ridley Shear stress--induced endothelial cell
polarization is mediated by Rho and Rac
but not Cdc42 or PI $3$-kinases . . . . 429
Alan W. Dove Stressed cells dance on a bright stage ??
Alan W. Dove Cut protein to boost fibers . . . . . . ??
Alan W. Dove Breaking down barriers . . . . . . . . . ??
Alan W. Dove Getting a handle on centrosomes . . . . ??
Alan W. Dove The neutrophil as firefighter . . . . . ??
Rabiya S. Tuma MicroRNAs make big splash in apoptosis ??
Rabiya S. Tuma Shared amyloid oligomer structure proves
toxic . . . . . . . . . . . . . . . . . ??
Rabiya S. Tuma Math connects vascular network to the
universe . . . . . . . . . . . . . . . . ??
Rabiya S. Tuma Turning RacGAP into a RhoGAP . . . . . . ??
Rabiya S. Tuma Crm1 locks up replication factors . . . ??
Karl Matter and
Maria S. Balda Holey barrier . . . . . . . . . . . . . 459
Jeffery W. Kelly and
William E. Balch Amyloid as a natural product . . . . . . 461
Ira Mellman and
Tom Misteli Computational cell biology . . . . . . . 463
John D. Aitchison and
Timothy Galitski Inventories to insights . . . . . . . . 465
José M. G. Vilar and
C\ualin C. Guet and
Stanislas Leibler Modeling network dynamics . . . . . . . 471
Roland Eils and
Chaitanya Athale Computational imaging in cell biology 477
Eric Hwang and
Justine Kusch and
Yves Barral and
Tim C. Huffaker Spindle orientation in
\bionameSaccharomyces cerevisiae depends
on the transport of microtubule ends
along polarized actin cables . . . . . . 483
Steven Ackerley and
Paul Thornhill and
Andrew J. Grierson and
Janet Brownlees and
Brian H. Anderton and
P. Nigel Leigh and
Christopher E. Shaw and
Christopher C. J. Miller Neurofilament heavy chain side arm
phosphorylation regulates axonal
transport of neurofilaments . . . . . . 489
Michel Jacquet and
Georges Renault and
Sylvie Lallet and
Jan De Mey and
Albert Goldbeter Oscillatory nucleocytoplasmic shuttling
of the general stress response
transcriptional activators Msn2 and Msn4
in \bionameSaccharomyces cerevisiae . . 497
Gopa Biswas and
Hindupur K. Anandatheerthavarada and
Mone Zaidi and
Narayan G. Avadhani Mitochondria to nucleus stress signaling 507
Joanne F. Berson and
Alexander C. Theos and
Dawn C. Harper and
Danielle Tenza and
Graça Raposo and
Michael S. Marks Proprotein convertase cleavage liberates
a fibrillogenic fragment of a resident
glycoprotein to initiate melanosome
biogenesis . . . . . . . . . . . . . . . 521
Adam Gromley and
Agata Jurczyk and
James Sillibourne and
Ensar Halilovic and
Mette Mogensen and
Irina Groisman and
Maureen Blomberg and
Stephen Doxsey A novel human protein of the maternal
centriole is required for the final
stages of cytokinesis and entry into S
phase . . . . . . . . . . . . . . . . . 535
Gabriella Castoria and
Maria Lombardi and
Maria Vittoria Barone and
Antonio Bilancio and
Marina Di Domenico and
Daniela Bottero and
Flavia Vitale and
Antimo Migliaccio and
Ferdinando Auricchio Androgen-stimulated DNA synthesis and
cytoskeletal changes in fibroblasts by a
nontranscriptional receptor action . . . 547
Kurt L. Barkalow and
Joseph E. Italiano and
Denise E. Chou and
Yoichiro Matsuoka and
Vann Bennett and
John H. Hartwig $ \alpha $-Adducin dissociates from
F-actin and spectrin during platelet
activation . . . . . . . . . . . . . . . 557
Sophie Nicole and
Benedicte Desforges and
Gaelle Millet and
Jeanne Lesbordes and
Carmen Cifuentes-Diaz and
Dora Vertes and
My Linh Cao and
Fabienne De Backer and
Laetitia Languille and
Natacha Roblot and
Vandana Joshi and
Jean-Marie Gillis and
Judith Melki Intact satellite cells lead to
remarkable protection against Smn gene
defect in differentiated skeletal muscle 571
Rui-An Wang and
Ratna K. Vadlamudi and
Rozita Bagheri-Yarmand and
Iwan Beuvink and
Nancy E. Hynes and
Rakesh Kumar Essential functions of p21-activated
kinase 1 in morphogenesis and
differentiation of mammary glands . . . 583
V. Sriram and
K. S. Krishnan and
Satyajit Mayor deep-orange and carnation define
distinct stages in late endosomal
biogenesis in \bionameDrosophila
melanogaster . . . . . . . . . . . . . . 593
Tanja Wucherpfennig and
Michaela Wilsch-Bräuninger and
Marcos González-Gaitán Role of \bionameDrosophila Rab5 during
endosomal trafficking at the synapse and
evoked neurotransmitter release . . . . 609
Iryna Leshchyns'ka and
Vladimir Sytnyk and
Jon S. Morrow and
Melitta Schachner Neural cell adhesion molecule (NCAM)
association with PKC$ \beta_2 $ via $
\beta $I spectrin is implicated in
NCAM-mediated neurite outgrowth . . . . 625
Gediminas Cepinskas and
Jurate Savickiene and
Carmen V. Ionescu and
Peter R. Kvietys PMN transendothelial migration decreases
nuclear NF$ \kappa $B in IL-1$ \beta
$-activated endothelial cells . . . . . 641
Takehiro Nitta and
Masaki Hata and
Shimpei Gotoh and
Yoshiteru Seo and
Hiroyuki Sasaki and
Nobuo Hashimoto and
Mikio Furuse and
Shoichiro Tsukita Size-selective loosening of the
blood-brain barrier in
claudin-$5$--deficient mice . . . . . . 653
Alan W. Dove Tumor cells . . . . . . . . . . . . . . ??
Alan W. Dove Modulating AMPA receptors makes memories
special . . . . . . . . . . . . . . . . ??
Alan W. Dove Dance of the podosomes . . . . . . . . . ??
Alan W. Dove Glycosylation's active site --- finally ??
Alan W. Dove Coping with the stress of morphogenesis ??
William A. Wells Small minerals make strong bones . . . . ??
William A. Wells Selectins with a catch . . . . . . . . . ??
William A. Wells Calcium goes nuclear . . . . . . . . . . ??
William A. Wells Metastasizing in search of oxygen . . . ??
William A. Wells A graveyard for mRNA . . . . . . . . . . ??
Rebecca Kellum Is HP1 an RNA detector that functions
both in repression and activation? . . . 671
Ivan R. Nabi and
Phuong U. Le Caveolae\slash raft-dependent
endocytosis . . . . . . . . . . . . . . 673
Ronald S. Ullers and
Edith N. G. Houben and
Amanda Raine and
Corinne M. ten Hagen-Jongman and
Måns Ehrenberg and
Joseph Brunner and
Bauke Oudega and
Nellie Harms and
Joen Luirink Interplay of signal recognition particle
and trigger factor at L23 near the
nascent chain exit site on the
\bionameEscherichia coli ribosome . . . 679
Yue Hu and
Mark E. Fortini Different cofactor activities in $
\gamma $-secretase assembly . . . . . . 685
Nia J. Bryant and
David E. James The Sec1p/Munc18 (SM) protein, Vps45p,
cycles on and off membranes during
vesicle transport . . . . . . . . . . . 691
James G. Evans and
Ivan Correia and
Olga Krasavina and
Nicki Watson and
Paul Matsudaira Macrophage podosomes assemble at the
leading lamella by growth and
fragmentation . . . . . . . . . . . . . 697
Lucia Piacentini and
Laura Fanti and
Maria Berloco and
Barbara Perrini and
Sergio Pimpinelli Heterochromatin protein 1 (HP1) is
associated with induced gene expression
in \bionameDrosophila euchromatin . . . 707
IngMarie Nilsson and
Daniel J. Kelleher and
Yiwei Miao and
Yuanlong Shao and
Gert Kreibich and
Reid Gilmore and
Gunnar von Heijne and
Arthur E. Johnson Photocross-linking of nascent chains to
the STT3 subunit of the
oligosaccharyltransferase complex . . . 715
Eric Lacazette and
Sophie Le Calvez and
Nadesan Gajendran and
Hans Rudolf Brenner A novel pathway for MuSK to induce key
genes in neuromuscular synapse formation 727
Ona Bloom and
Emma Evergren and
Nikolay Tomilin and
Ole Kjaerulff and
Peter Löw and
Lennart Brodin and
Vincent A. Pieribone and
Paul Greengard and
Oleg Shupliakov Colocalization of synapsin and actin
during synaptic vesicle recycling . . . 737
Daniel Jaquemar and
Sergey Kupriyanov and
Miriam Wankell and
Jacqueline Avis and
Kurt Benirschke and
Hél\`ene Baribault and
Robert G. Oshima Keratin 8 protection of placental
barrier function . . . . . . . . . . . . 749
Julia M. Bosher and
Bum-Soo Hahn and
Renaud Legouis and
Satis Sookhareea and
Robby M. Weimer and
Anne Gansmuller and
Andrew D. Chisholm and
Ann M. Rose and
Jean-Louis Bessereau and
Michel Labouesse The \bionameCaenorhabditis elegans
vab-10 spectraplakin isoforms protect
the epidermis against internal and
external forces . . . . . . . . . . . . 757
Laird C. Sheldahl and
Diane C. Slusarski and
Petra Pandur and
Jeffrey R. Miller and
Michael Kühl and
Randall T. Moon Dishevelled activates Ca$^{2+}$ flux,
PKC, and CamKII in vertebrate embryos 769
Chang Xu and
James Watras and
Leslie M. Loew Kinetic analysis of receptor-activated
phosphoinositide turnover . . . . . . . 779
Maria Grazia Lampugnani and
Adriana Zanetti and
Monica Corada and
Takamune Takahashi and
Giovanna Balconi and
Ferruccio Breviario and
Fabrizio Orsenigo and
Anna Cattelino and
Rolf Kemler and
Thomas O. Daniel and
Elisabetta Dejana Contact inhibition of VEGF-induced
proliferation requires vascular
endothelial cadherin, $ \beta $-catenin,
and the phosphatase DEP-1/CD148 . . . . 793
Susumu Tomita and
Lu Chen and
Yoshimi Kawasaki and
Ronald S. Petralia and
Robert J. Wenthold and
Roger A. Nicoll and
David S. Bredt Functional studies and distribution
define a family of transmembrane AMPA
receptor regulatory proteins . . . . . . 805
Thomas Manes and
Duo-Qi Zheng and
Simona Tognin and
Amy S. Woodard and
Pier Carlo Marchisio and
Lucia R. Languino $ \alpha_v \beta_3 $ integrin expression
up-regulates cdc2, which modulates cell
migration . . . . . . . . . . . . . . . 817
Alan W. Dove Conjunctions of junctions . . . . . . . ??
Alan W. Dove Wrong connexin signals cataracts . . . . ??
Alan W. Dove Agrin at CNS synapses . . . . . . . . . ??
Alan W. Dove Catching a kinase in the act . . . . . . ??
Alan W. Dove Fusion promoter or fusion inhibitor? . . ??
Nicole LeBrasseur A view of antibody maturation . . . . . ??
Nicole LeBrasseur GPR-1\slash 2 support unequal division ??
Nicole LeBrasseur Apoptosis leaves its mark on chromatin ??
Nicole LeBrasseur A cytokine that packs a punch . . . . . ??
Nicole LeBrasseur Cyclin B knows its place . . . . . . . . ??
Mike Rossner The JCB 2003 . . . . . . . . . . . . . . 837
Joanna Cichy and
Ellen Puré The liberation of CD44 . . . . . . . . . 839
Torsten Wittmann and
Gary M. Bokoch and
Clare M. Waterman-Storer Regulation of leading edge microtubule
and actin dynamics downstream of Rac1 845
Olga Krylyshkina and
Kurt I. Anderson and
Irina Kaverina and
Irene Upmann and
Dietmar J. Manstein and
J. Victor Small and
Derek K. Toomre Nanometer targeting of microtubules to
focal adhesions . . . . . . . . . . . . 853
William Schubert and
Xiao Yong Yang and
Teddy T. C. Yang and
Stephen M. Factor and
Michael P. Lisanti and
Jeffery D. Molkentin and
Mercedes Rincón and
Chi-Wing Chow Requirement of transcription factor NFAT
in developing atrial myocardium . . . . 861
David R. Kovar and
Jeffrey R. Kuhn and
Andrea L. Tichy and
Thomas D. Pollard The fission yeast cytokinesis formin
Cdc12p is a barbed end actin filament
capping protein gated by profilin . . . 875
Satoshi Yoshida and
Ryuji Ichihashi and
Akio Toh-e Ras recruits mitotic exit regulator Lte1
to the bud cortex in budding yeast . . . 889
Jonathan D. Violin and
Jin Zhang and
Roger Y. Tsien and
Alexandra C. Newton A genetically encoded fluorescent
reporter reveals oscillatory
phosphorylation by protein kinase C . . 899
Prithi Rajan and
David M. Panchision and
Laura F. Newell and
Ronald D. G. McKay BMPs signal alternately through a SMAD
or FRAP--STAT pathway to regulate fate
choice in CNS stem cells . . . . . . . . 911
Cameron L. Hoover and
Lutz G. W. Hilgenberg and
Martin A. Smith The COOH-terminal domain of agrin
signals via a synaptic receptor in
central nervous system neurons . . . . . 923
Paola Chiarugi and
Giovambattista Pani and
Elisa Giannoni and
Letizia Taddei and
Renata Colavitti and
Giovanni Raugei and
Mark Symons and
Silvia Borrello and
Tommaso Galeotti and
Giampietro Ramponi Reactive oxygen species as essential
mediators of cell adhesion . . . . . . . 933
Yoshito Takeda and
Isao Tachibana and
Kenji Miyado and
Masatoshi Kobayashi and
Toru Miyazaki and
Toshiki Funakoshi and
Hiromi Kimura and
Hiroyuki Yamane and
Yoshiyuki Saito and
Hiroyuki Goto and
Tsutomu Yoneda and
Mitsuhiro Yoshida and
Toru Kumagai and
Tadashi Osaki and
Seiji Hayashi and
Ichiro Kawase and
Eisuke Mekada Tetraspanins CD9 and CD81 function to
prevent the fusion of mononuclear
phagocytes . . . . . . . . . . . . . . . 945
Yuko Iwata and
Yuki Katanosaka and
Yuji Arai and
Kazuo Komamura and
Kunio Miyatake and
Munekazu Shigekawa A novel mechanism of myocyte
degeneration involving the
Ca$^{2+}$-permeable growth
factor--regulated channel . . . . . . . 957
Francisco J. Martinez-Wittinghan and
Caterina Sellitto and
Leping Li and
Xiaohua Gong and
Peter R. Brink and
Richard T. Mathias and
Thomas W. White Dominant cataracts result from
incongruous mixing of wild-type lens
connexins . . . . . . . . . . . . . . . 969
Jennifer L. Genova and
Richard G. Fehon Neuroglian, Gliotactin, and the Na$^+$
/K$^+$ ATPase are essential for septate
junction function in \bionameDrosophila 979
Joost Schulte and
Ulrich Tepass and
Vanessa J. Auld Gliotactin, a novel marker of
tricellular junctions, is necessary for
septate junction development in
\bionameDrosophila . . . . . . . . . . . 991
Nicole LeBrasseur Two ways VEGF--A builds a vessel . . . . ??
Nicole LeBrasseur Catastrophe under pressure . . . . . . . ??
Nicole LeBrasseur E-cadherin immobilizes cells from the
inside . . . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Golgi united are also divided . . . . . ??
Nicole LeBrasseur NRG-1 talks back to neurons . . . . . . ??
William A. Wells A tumorigenic culprit in ES cells . . . ??
William A. Wells WASPs with memory . . . . . . . . . . . ??
William A. Wells Helicobacter breaks down junctions . . . ??
William A. Wells Committing to mitosis . . . . . . . . . ??
William A. Wells Anchored by feedback . . . . . . . . . . ??
Morris J. Birnbaum Lipolysis . . . . . . . . . . . . . . . 1011
Nica Borgese and
Sara Colombo and
Emanuela Pedrazzini The tale of tail-anchored proteins . . . 1013
Melinda M. Horne and
Thomas M. Guadagno A requirement for MAP kinase in the
assembly and maintenance of the mitotic
spindle . . . . . . . . . . . . . . . . 1021
Marcel E. Janson and
Mathilde E. de Dood and
Marileen Dogterom Dynamic instability of microtubules is
regulated by force . . . . . . . . . . . 1029
Vladimír Reiser and
Desmond C. Raitt and
Haruo Saito Yeast osmosensor Sln1 and plant
cytokinin receptor Cre1 respond to
changes in turgor pressure . . . . . . . 1035
Sarah M. Wignall and
Renée Deehan and
Thomas J. Maresca and
Rebecca Heald The condensin complex is required for
proper spindle assembly and chromosome
segregation in \bionameXenopus egg
extracts . . . . . . . . . . . . . . . . 1041
Lisa Dailey and
Emmanuel Laplantine and
Riccardo Priore and
Claudio Basilico A network of transcriptional and
signaling events is activated by FGF to
induce chondrocyte growth arrest and
differentiation . . . . . . . . . . . . 1053
Keiji Uchiyama and
Eija Jokitalo and
Mervi Lindman and
Mark Jackman and
Fumi Kano and
Masayuki Murata and
Xiaodong Zhang and
Hisao Kondo The localization and phosphorylation of
p47 are important for Golgi
disassembly--assembly during the cell
cycle . . . . . . . . . . . . . . . . . 1067
Yuqing Dong and
David Pruyne and
Anthony Bretscher Formin-dependent actin assembly is
regulated by distinct modes of Rho
signaling in yeast . . . . . . . . . . . 1081
Carole Sztalryd and
Guoheng Xu and
Heidi Dorward and
John T. Tansey and
Juan A. Contreras and
Alan R. Kimmel and
Constantine Londos Perilipin A is essential for the
translocation of hormone-sensitive
lipase during lipolytic activation . . . 1093
Thomas Herrmann and
Frank van der Hoeven and
Hermann-Josef Gröne and
Adrian Francis Stewart and
Lutz Langbein and
Iris Kaiser and
Gerhard Liebisch and
Isabella Gosch and
Florian Buchkremer and
Wolfgang Drobnik and
Gerd Schmitz and
Wolfgang Stremmel Mice with targeted disruption of the
fatty acid transport protein 4 (Fatp 4,
Slc27a4) gene show features of lethal
restrictive dermopathy . . . . . . . . . 1105
Kyohei Umebayashi and
Akihiko Nakano Ergosterol is required for targeting of
tryptophan permease to the yeast plasma
membrane . . . . . . . . . . . . . . . . 1117
Jianxin Bao and
Deon Wolpowitz and
Lorna W. Role and
David A. Talmage Back signaling by the Nrg-1
intracellular domain . . . . . . . . . . 1133
Florence Niedergang and
Emma Colucci-Guyon and
Thierry Dubois and
Graça Raposo and
Philippe Chavrier ADP ribosylation factor 6 is activated
and controls membrane delivery during
phagocytosis in macrophages . . . . . . 1143
Haihua Gu and
Roberto J. Botelho and
Min Yu and
Sergio Grinstein and
Benjamin G. Neel Critical role for scaffolding adapter
Gab2 in Fc$ \gamma $R-mediated
phagocytosis . . . . . . . . . . . . . . 1151
Holger Gerhardt and
Matthew Golding and
Marcus Fruttiger and
Christiana Ruhrberg and
Andrea Lundkvist and
Alexandra Abramsson and
Michael Jeltsch and
Christopher Mitchell and
Kari Alitalo and
David Shima and
Christer Betsholtz VEGF guides angiogenic sprouting
utilizing endothelial tip cell filopodia 1163
Anthony Wayne Orr and
Claudio E. Pedraza and
Manuel Antonio Pallero and
Carrie A. Elzie and
Silvia Goicoechea and
Dudley K. Strickland and
Joanne E. Murphy-Ullrich Low density lipoprotein
receptor--related protein is a
calreticulin coreceptor that signals
focal adhesion disassembly . . . . . . . 1179
Alice S. T. Wong and
Barry M. Gumbiner Adhesion-independent mechanism for
suppression of tumor cell invasion by
E-cadherin . . . . . . . . . . . . . . . 1191
Alan W. Dove Histones help clones forget their pasts ??
Alan W. Dove A fusion inhibitor on endosomes . . . . ??
Alan W. Dove Controlling flagellar strokes . . . . . ??
Alan W. Dove Splicing fibronectin's functions . . . . ??
Alan W. Dove Hierarchical condensation . . . . . . . ??
Nicole LeBrasseur Fibronectin for branching . . . . . . . ??
Nicole LeBrasseur Spare the Mbl, spoil the rod? . . . . . ??
Nicole LeBrasseur Remodeling the nucleus . . . . . . . . . ??
Nicole LeBrasseur and
Nicole LeBrasseur Glutamate in unusual places . . . . . . ??
Nicole LeBrasseur and
Nicole LeBrasseur Dying cells say come-hither . . . . . . ??
Jonathan Pettitt and
Elisabeth A. Cox and
Ian D. Broadbent and
Aileen Flett and
Jeff Hardin The \bionameCaenorhabditis elegans p120
catenin homologue, JAC-1, modulates
cadherin--catenin function during
epidermal morphogenesis . . . . . . . . 15
Yuri G. Strukov and
Yan Wang and
Andrew S. Belmont Engineered chromosome regions with
altered sequence composition demonstrate
hierarchical large-scale folding within
metaphase chromosomes . . . . . . . . . 23
Jin-Moon Kim and
Honglin Liu and
Mayuko Tazaki and
Masao Nagata and
Fugaku Aoki Changes in histone acetylation during
mouse oocyte meiosis . . . . . . . . . . 37
Gerald Rupp and
Mary E. Porter A subunit of the dynein regulatory
complex in Chlamydomonas is a homologue
of a growth arrest--specific gene
product . . . . . . . . . . . . . . . . 47
Wei-Xing Zong and
Chi Li and
Georgia Hatzivassiliou and
Tullia Lindsten and
Qian-Chun Yu and
Junying Yuan and
Craig B. Thompson Bax and Bak can localize to the
endoplasmic reticulum to initiate
apoptosis . . . . . . . . . . . . . . . 59
Yihong Ye and
Hemmo H. Meyer and
Tom A. Rapoport Function of the p97--Ufd1--Npl4 complex
in retrotranslocation from the ER to the
cytosol . . . . . . . . . . . . . . . . 71
Mitsuhiro Abe and
Hiroshi Qadota and
Aiko Hirata and
Yoshikazu Ohya Lack of GTP-bound Rho1p in secretory
vesicles of \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 85
Maria Cruz Martinez and
Tomoyo Ochiishi and
Michael Majewski and
Kenneth S. Kosik Dual regulation of neuronal
morphogenesis by a $ \delta
$-catenin--cortactin complex and Rho . . 99
Michael Krauss and
Masahiro Kinuta and
Markus R. Wenk and
Pietro De Camilli and
Kohji Takei and
Volker Haucke ARF6 stimulates clathrin/AP-2
recruitment to synaptic membranes by
activating phosphatidylinositol
phosphate kinase type I$ \gamma $ . . . 113
Wei Sun and
Qing Yan and
Thomas A. Vida and
Andrew J. Bean Hrs regulates early endosome fusion by
inhibiting formation of an endosomal
SNARE complex . . . . . . . . . . . . . 125
Leonieke Terpstra and
Josée Prud'homme and
Alice Arabian and
Shu Takeda and
Gérard Karsenty and
Shoukat Dedhar and
René St-Arnaud Reduced chondrocyte proliferation and
chondrodysplasia in mice lacking the
integrin-linked kinase in chondrocytes 139
Andrés F. Muro and
Anil K. Chauhan and
Srecko Gajovic and
Alessandra Iaconcig and
Fabiola Porro and
Giorgio Stanta and
Francisco E. Baralle Regulated splicing of the fibronectin
EDA exon is essential for proper skin
wound healing and normal lifespan . . . 149
Nicole LeBrasseur Polyamines in inflammation . . . . . . . ??
Nicole LeBrasseur Desulfation on the cell surface . . . . ??
Nicole LeBrasseur A building block of two organelles . . . ??
Nicole LeBrasseur Neural cells turn and run . . . . . . . ??
Nicole LeBrasseur Kicking out antiviral proteins . . . . . ??
William A. Wells A loss, or two gains? . . . . . . . . . ??
William A. Wells Nervous picket fences . . . . . . . . . ??
William A. Wells Sticky transmission . . . . . . . . . . ??
William A. Wells Activation by reduction . . . . . . . . ??
William A. Wells Doing the CDC20 shuffle . . . . . . . . ??
Michael J. Held Proposed legislation supports an
untested publishing model . . . . . . . 171
Naoko Ohtani and
Paul Brennan and
Stefan Gaubatz and
Elaine Sanij and
Paul Hertzog and
Ernst Wolvetang and
Jacques Ghysdael and
Martin Rowe and
Eiji Hara Epstein--Barr virus LMP1 blocks
p16$^{\rm INK4a}$-RB pathway by
promoting nuclear export of E2F4/5 . . . 173
Vangelis Kondylis and
Catherine Rabouille A novel role for dp115 in the
organization of tER sites in
\bionameDrosophila . . . . . . . . . . . 185
Ward C. Tucker and
J. Michael Edwardson and
Jihong Bai and
Hyun-Jung Kim and
Thomas F. J. Martin and
Edwin R. Chapman Identification of synaptotagmin
effectors via acute inhibition of
secretion from cracked PC12 cells . . . 199
Martin J. Bayer and
Christoph Reese and
Susanne Bühler and
Christopher Peters and
Andreas Mayer Vacuole membrane fusion . . . . . . . . 211
Hisayoshi Yoshizaki and
Yusuke Ohba and
Kazuo Kurokawa and
Reina E. Itoh and
Takeshi Nakamura and
Naoki Mochizuki and
Kazuo Nagashima and
Michiyuki Matsuda Activity of Rho-family GTPases during
cell division as visualized with
FRET-based probes . . . . . . . . . . . 223
Catherine I. Dubreuil and
Matthew J. Winton and
Lisa McKerracher Rho activation patterns after spinal
cord injury and the role of activated
Rho in apoptosis in the central nervous
system . . . . . . . . . . . . . . . . . 233
Louis K. Chang and
Robert E. Schmidt and
Eugene M. Johnson Alternating metabolic pathways in
NGF-deprived sympathetic neurons affect
caspase-independent death . . . . . . . 245
Denis Soulet and
Serge Rivest Polyamines play a critical role in the
control of the innate immune response in
the mouse central nervous system . . . . 257
Maria Elena De Bellard and
Yi Rao and
Marianne Bronner-Fraser Dual function of Slit2 in repulsion and
enhanced migration of trunk, but not
vagal, neural crest cells . . . . . . . 269
Jill K. Slack-Davis and
Scott T. Eblen and
Maja Zecevic and
Scott A. Boerner and
Adel Tarcsafalvi and
H. Bruce Diaz and
Mark S. Marshall and
Michael J. Weber and
J. Thomas Parsons and
Andrew D. Catling PAK1 phosphorylation of MEK1 regulates
fibronectin-stimulated MAPK activation 281
Dong Min Shin and
Marlin Dehoff and
Xiang Luo and
Shin Hyeok Kang and
Jiangchen Tu and
Surendra K. Nayak and
Elliott M. Ross and
Paul F. Worley and
Shmuel Muallem Homer 2 tunes G protein--coupled
receptors stimulus intensity by
regulating RGS proteins and PLC$ \beta $
GAP activities . . . . . . . . . . . . . 293
Guangwei Du and
Yelena M. Altshuller and
Nicolas Vitale and
Ping Huang and
Sylvette Chasserot-Golaz and
Andrew J. Morris and
Marie-France Bader and
Michael A. Frohman Regulation of phospholipase D1
subcellular cycling through coordination
of multiple membrane association motifs 305
Tim-Wolf Gilberger and
Jennifer K. Thompson and
Michael B. Reed and
Robert T. Good and
Alan F. Cowman The cytoplasmic domain of the Plasmodium
falciparum ligand EBA-175 is essential
for invasion but not protein trafficking 317
Xiaodong Xi and
Richard J. Bodnar and
Zhenyu Li and
Stephen C.-T. Lam and
Xiaoping Du Critical roles for the COOH-terminal
NITY and RGT sequences of the integrin $
\beta_3 $ cytoplasmic domain in
inside-out and outside-in signaling . . 329
Xingbin Ai and
Anh-Tri Do and
Olga Lozynska and
Marion Kusche-Gullberg and
Ulf Lindahl and
Charles P. Emerson QSulf1 remodels the 6-O sulfation states
of cell surface heparan sulfate
proteoglycans to promote Wnt signaling 341
Alan W. Dove When myosin heads go walking . . . . . . ??
Alan W. Dove Schwann cells don caps, touch nodes . . ??
Alan W. Dove Neural progenitors play favorites . . . ??
Alan W. Dove A simple way to get cleavage . . . . . . ??
Alan W. Dove Watching kinetochores sweat . . . . . . ??
Rabiya Tuma Cilia take charge in L--R asymmetry . . ??
Rabiya Tuma Network architecture determines
stability . . . . . . . . . . . . . . . ??
Rabiya Tuma Exocytosis --- one vesicle at a time . . ??
Rabiya Tuma The elusive cell cycle--transcription
link . . . . . . . . . . . . . . . . . . ??
Rabiya Tuma Loss of Rb launches cell cycle . . . . . ??
Eric C. Lai Lipid rafts make for slippery platforms 365
Ali Amara and
Dan R. Littman After Hrs with HIV . . . . . . . . . . . 371
Paul Maddox and
Aaron Straight and
Peg Coughlin and
Timothy J. Mitchison and
Edward D. Salmon Direct observation of microtubule
dynamics at kinetochores in
\bionameXenopus extract spindles . . . . 377
G. Bradley Alsop and
Dahong Zhang Microtubules are the only structural
constituent of the spindle apparatus
required for induction of cell cleavage 383
Janna Bednenko and
Gino Cingolani and
Larry Gerace Importin $ \beta $ contains a
COOH-terminal nucleoporin binding region
important for nuclear transport . . . . 391
Pierre Morsomme and
Cristina Prescianotto-Baschong and
Howard Riezman The ER v--SNAREs are required for
GPI-anchored protein sorting from other
secretory proteins upon exit from the ER 403
David J. Katzmann and
Christopher J. Stefan and
Markus Babst and
Scott D. Emr Vps27 recruits ESCRT machinery to
endosomes during MVB sorting . . . . . . 413
Owen Pornillos and
Daniel S. Higginson and
Kirsten M. Stray and
Robert D. Fisher and
Jennifer E. Garrus and
Marielle Payne and
Gong-Ping He and
Hubert E. Wang and
Scott G. Morham and
Wesley I. Sundquist HIV Gag mimics the Tsg101-recruiting
activity of the human Hrs protein . . . 425
Kristi G. Bache and
Andreas Brech and
Anja Mehlum and
Harald Stenmark Hrs regulates multivesicular body
formation via ESCRT recruitment to
endosomes . . . . . . . . . . . . . . . 435
Annegret Pelchen-Matthews and
Beatrice Kramer and
Mark Marsh Infectious HIV-1 assembles in late
endosomes in primary macrophages . . . . 443
Michael Kalai and
Mohamed Lamkanfi and
Geertrui Denecker and
Michael Boogmans and
Saskia Lippens and
Ann Meeus and
Wim Declercq and
Peter Vandenabeele Regulation of the expression and
processing of caspase-12 . . . . . . . . 457
Erhard Bieberich and
Sarah MacKinnon and
Jeane Silva and
Scott Noggle and
Brian G. Condie Regulation of cell death in mitotic
neural progenitor cells by asymmetric
distribution of prostate apoptosis
response 4 (PAR-4) and simultaneous
elevation of endogenous ceramide . . . . 469
Neil M. Kad and
Arthur S. Rovner and
Patricia M. Fagnant and
Peteranne B. Joel and
Guy G. Kennedy and
Joseph B. Patlak and
David M. Warshaw and
Kathleen M. Trybus A mutant heterodimeric myosin with one
inactive head generates maximal
displacement . . . . . . . . . . . . . . 481
Cheryl L. Gatto and
Barbara J. Walker and
Stephen Lambert Local ERM activation and dynamic growth
cones at Schwann cell tips implicated in
efficient formation of nodes of Ranvier 489
Roberta Faccio and
Deborah V. Novack and
Alberta Zallone and
F. Patrick Ross and
Steven L. Teitelbaum Dynamic changes in the osteoclast
cytoskeleton in response to growth
factors and cell attachment are
controlled by $ \beta $3 integrin . . . 499
Yvan Torrente and
Geoffrey Camirand and
Federica Pisati and
Marzia Belicchi and
Barbara Rossi and
Fabio Colombo and
Mosthapha El Fahime and
Nicolas J. Caron and
Andrew C. Issekutz and
Gabriela Constantin and
Jacques P. Tremblay and
Nereo Bresolin Identification of a putative pathway for
the muscle homing of stem cells in a
muscular dystrophy model . . . . . . . . 511
Nicole LeBrasseur Prions prefer caveosomes . . . . . . . . ??
Nicole LeBrasseur Stop and go L1CAM . . . . . . . . . . . ??
Nicole LeBrasseur Synapse too exclusive for CD148 . . . . ??
Nicole LeBrasseur G-proteins for spindle geometry . . . . ??
Nicole LeBrasseur BubR1 checks in with CENP--E . . . . . . ??
William A. Wells Pulling backwards . . . . . . . . . . . ??
William A. Wells Reprogrammed by a frog . . . . . . . . . ??
William A. Wells Surviving heat through destruction . . . ??
William A. Wells My mother, the wave . . . . . . . . . . ??
William A. Wells The checkpoint of death . . . . . . . . ??
Marta L. Hribal and
Jun Nakae and
Tadahiro Kitamura and
John R. Shutter and
Domenico Accili Regulation of insulin-like growth
factor-dependent myoblast
differentiation by Foxo forkhead
transcription factors . . . . . . . . . 535
Sabyasachi Chakrabarti and
Koichi S. Kobayashi and
Richard A. Flavell and
Carolyn B. Marks and
Katsuya Miyake and
David R. Liston and
Kimberly T. Fowler and
Fred S. Gorelick and
Norma W. Andrews Impaired membrane resealing and
autoimmune myositis in synaptotagmin
VII--deficient mice . . . . . . . . . . 543
Beth A. A. Weaver and
Zahid Q. Bonday and
Frances R. Putkey and
Geert J. P. L. Kops and
Alain D. Silk and
Don W. Cleveland Centromere-associated protein--E is
essential for the mammalian mitotic
checkpoint to prevent aneuploidy due to
single chromosome loss . . . . . . . . . 551
Keith Byrd and
Victor G. Corces Visualization of chromatin domains
created by the gypsy insulator of
\bionameDrosophila . . . . . . . . . . . 565
Elisabet C. Mandon and
Ying Jiang and
Reid Gilmore Dual recognition of the ribosome and the
signal recognition particle by the SRP
receptor during protein targeting to the
endoplasmic reticulum . . . . . . . . . 575
Claus Reimertz and
Donat Kögel and
Abdelhaq Rami and
Thomas Chittenden and
Jochen H. M. Prehn Gene expression during ER
stress--induced apoptosis in neurons . . 587
Anthony J. Valentijn and
Anthony D. Metcalfe and
Jane Kott and
Charles H. Streuli and
Andrew P. Gilmore Spatial and temporal changes in Bax
subcellular localization during anoikis 599
Jonathan Gilley and
Paul J. Coffer and
Jonathan Ham FOXO transcription factors directly
activate bim gene expression and promote
apoptosis in sympathetic neurons . . . . 613
Fengwei Yu and
Yu Cai and
Rachna Kaushik and
Xiaohang Yang and
William Chia Distinct roles of G$ \alpha $i and G$
\beta $13F subunits of the
heterotrimeric G protein complex in the
mediation of \bionameDrosophila
neuroblast asymmetric divisions . . . . 623
Xiang-Dong Gao and
Stefan Albert and
Serguei E. Tcheperegine and
Christopher G. Burd and
Dieter Gallwitz and
Erfei Bi The GAP activity of Msb3p and Msb4p for
the Rab GTPase Sec4p is required for
efficient exocytosis and actin
organization . . . . . . . . . . . . . . 635
Yoshikatsu Aikawa and
Thomas F. J. Martin ARF6 regulates a plasma membrane pool of
phosphatidylinositol(4,5)bisphosphate
required for regulated exocytosis . . . 647
Cécile Vindis and
Douglas Pat Cerretti and
Thomas O. Daniel and
Uyen Huynh-Do EphB1 recruits c--Src and p52$^{\rm
Shc}$ to activate MAPK/ERK and promote
chemotaxis . . . . . . . . . . . . . . . 661
Joseph Lin and
Arthur Weiss The tyrosine phosphatase CD148 is
excluded from the immunologic synapse
and down-regulates prolonged T cell
signaling . . . . . . . . . . . . . . . 673
Zeev Shmelzer and
Nurit Haddad and
Ester Admon and
Itai Pessach and
Thomas L. Leto and
Zahit Eitan-Hazan and
Michal Hershfinkel and
Rachel Levy Unique targeting of cytosolic
phospholipase A$_2$ to plasma membranes
mediated by the NADPH oxidase in
phagocytes . . . . . . . . . . . . . . . 683
David Padrón and
Ying Jie Wang and
Masaya Yamamoto and
Helen Yin and
Michael G. Roth Phosphatidylinositol phosphate
$5$-kinase I$ \beta $ recruits AP-2 to
the plasma membrane and regulates rates
of constitutive endocytosis . . . . . . 693
Peter J. Peters and
Alexander Mironov and
David Peretz and
Elly van Donselaar and
Estelle Leclerc and
Susanne Erpel and
Stephen J. DeArmond and
Dennis R. Burton and
R. Anthony Williamson and
Martin Vey and
Stanley B. Prusiner Trafficking of prion proteins through a
caveolae-mediated endosomal pathway . . 703
Orlando D. Gil and
Takeshi Sakurai and
Ann E. Bradley and
Marc Y. Fink and
Melanie R. Cassella and
James A. Kuo and
Dan P. Felsenfeld Ankyrin binding mediates L1CAM
interactions with static components of
the cytoskeleton and inhibits retrograde
movement of L1CAM on the cell surface 719
Lawrence E. Goldfinger and
Jaewon Han and
William B. Kiosses and
Alan K. Howe and
Mark H. Ginsberg Spatial restriction of $ \alpha $4
integrin phosphorylation regulates
lamellipodial stability and $ \alpha $4$
\beta $1-dependent cell migration . . . 731
Alan W. Dove Wnt separate ways, met later . . . . . . ??
Alan W. Dove Linking formins to Arp2/3 . . . . . . . ??
Alan W. Dove A prolific nucleator program . . . . . . ??
Alan W. Dove Bcl-w buries its tail, lets cell die . . ??
Alan W. Dove AP-2 gets demoted . . . . . . . . . . . ??
Nicole LeBrasseur How cholesterol clogs the arteries . . . ??
Nicole LeBrasseur Lonely receptors kill cells . . . . . . ??
Nicole LeBrasseur The healing power of Ron . . . . . . . . ??
Nicole LeBrasseur Nucleotides choose origins . . . . . . . ??
Nicole LeBrasseur Losing self-awareness . . . . . . . . . ??
Gilbert Weidinger and
Randall T. Moon When Wnts antagonize Wnts . . . . . . . 753
Yasuhiko Terada and
Yumi Uetake and
Ryoko Kuriyama Interaction of Aurora--A and centrosomin
at the microtubule-nucleating site in
\bionameDrosophila and mammalian cells 757
Mariko Sekiya-Kawasaki and
Aaron Chris Groen and
M. Jamie T. V. Cope and
Marko Kaksonen and
Hadiya A. Watson and
Chao Zhang and
Kevan M. Shokat and
Beverly Wendland and
Kent L. McDonald and
J. Michael McCaffery and
David G. Drubin Dynamic phosphoregulation of the
cortical actin cytoskeleton and
endocytic machinery revealed by
real-time chemical genetic analysis . . 765
Sean D. Conner and
Sandra L. Schmid Differential requirements for AP-2 in
clathrin-mediated endocytosis . . . . . 773
Stephan J. Kempiak and
Shu-Chin Yip and
Jonathan M. Backer and
Jeffrey E. Segall Local signaling by the EGF receptor . . 781
Justin Sturge and
Dirk Wienke and
Lucy East and
Gareth E. Jones and
Clare M. Isacke GPI-anchored uPAR requires Endo180 for
rapid directional sensing during
chemotaxis . . . . . . . . . . . . . . . 789
Thierry Voet and
Bodo Liebe and
Charlotte Labaere and
Peter Marynen and
Harry Scherthan Telomere-independent homologue pairing
and checkpoint escape of accessory ring
chromosomes in male mouse meiosis . . . 795
Marion Cremer and
Katrin Küpper and
Babett Wagler and
Leah Wizelman and
Johann v. Hase and
Yanina Weiland and
Ludwika Kreja and
Joachim Diebold and
Michael R. Speicher and
Thomas Cremer Inheritance of gene density--related
higher order chromatin arrangements in
normal and tumor cell nuclei . . . . . . 809
Susan A. Gerbi and
Anton V. Borovjagin and
Federico E. Odreman and
Thilo Sascha Lange U4 snRNA nucleolar localization requires
the NHPX/15.5-kD protein binding site
but not Sm protein or U6 snRNA
association . . . . . . . . . . . . . . 821
Qiping Zheng and
Guang Zhou and
Roy Morello and
Yuqing Chen and
Xavier Garcia-Rojas and
Brendan Lee Type X collagen gene regulation by Runx2
contributes directly to its hypertrophic
chondrocyte--specific expression in vivo 833
Theresa Jordan and
Jinyuan Li and
Hongbin Jiang and
Joseph X. DiMario Repression of slow myosin heavy chain 2
gene expression in fast skeletal muscle
fibers by muscarinic acetylcholine
receptor and G$ \alpha $q signaling . . 843
Robert H. Carnahan and
Kathleen L. Gould The PCH family protein, Cdc15p, recruits
two F-actin nucleation pathways to
coordinate cytokinetic actin ring
formation in Schizosaccharomyces pombe 851
Rüdiger Neef and
Christian Preisinger and
Josephine Sutcliffe and
Robert Kopajtich and
Erich A. Nigg and
Thomas U. Mayer and
Francis A. Barr Phosphorylation of mitotic kinesin-like
protein 2 by polo-like kinase 1 is
required for cytokinesis . . . . . . . . 863
Julie Wilson-Annan and
Lorraine A. O'Reilly and
Simon A. Crawford and
George Hausmann and
Jennifer G. Beaumont and
Loes P. Parma and
Lin Chen and
Martin Lackmann and
Trevor Lithgow and
Mark G. Hinds and
Catherine L. Day and
Jerry M. Adams and
David C. S. Huang Proapoptotic BH3-only proteins trigger
membrane integration of prosurvival
Bcl-w and neutralize its activity . . . 877
Trudi A. Westfall and
Ryan Brimeyer and
Jen Twedt and
Jean Gladon and
Andrea Olberding and
Makoto Furutani-Seiki and
Diane C. Slusarski Wnt-5/pipetail functions in vertebrate
axis formation as a negative regulator
of Wnt/$ \beta $-catenin activity . . . 889
Lilia Topol and
Xueyuan Jiang and
Hosoon Choi and
Lisa Garrett-Beal and
Peter J. Carolan and
Yingzi Yang Wnt-5a inhibits the canonical Wnt
pathway by promoting GSK-3--independent
$ \beta $-catenin degradation . . . . . 899
Alison Motley and
Nicholas A. Bright and
Matthew N. J. Seaman and
Margaret S. Robinson Clathrin-mediated endocytosis in
AP-2--depleted cells . . . . . . . . . . 909
Michelle L. McWhorter and
Umrao R. Monani and
Arthur H. M. Burghes and
Christine E. Beattie Knockdown of the survival motor neuron
(Smn) protein in zebrafish causes
defects in motor axon outgrowth and
pathfinding . . . . . . . . . . . . . . 919
John D. Hood and
Ricardo Frausto and
William B. Kiosses and
Martin A. Schwartz and
David A. Cheresh Differential $ \alpha $v
integrin--mediated Ras--ERK signaling
during two pathways of angiogenesis . . 933
Nicole LeBrasseur We can deplete it, we have the
technology . . . . . . . . . . . . . . . ??
Nicole LeBrasseur When nuclear proteins go mitotic . . . . ??
Nicole LeBrasseur The glue that builds bristles . . . . . ??
Nicole LeBrasseur More order in DNA . . . . . . . . . . . ??
Nicole LeBrasseur Finding the axon . . . . . . . . . . . . ??
William A. Wells When is a virus an exosome? . . . . . . ??
William A. Wells Centromere errors get chewed out . . . . ??
William A. Wells Survival is sweet . . . . . . . . . . . ??
William A. Wells A daughter's size is not critical . . . ??
William A. Wells Pulling to the protease . . . . . . . . ??
Anton Burakov and
Elena Nadezhdina and
Boris Slepchenko and
Vladimir Rodionov Centrosome positioning in interphase
cells . . . . . . . . . . . . . . . . . 963
A. Petiot and
J. Fauré and
H. Stenmark and
J. Gruenberg PI3P signaling regulates receptor
sorting but not transport in the
endosomal pathway . . . . . . . . . . . 971
Lindsay S. Shopland and
Carol V. Johnson and
Meg Byron and
John McNeil and
Jeanne B. Lawrence Clustering of multiple specific genes
and gene-rich R-bands around SC-35
domains . . . . . . . . . . . . . . . . 981
Davide Salina and
Paul Enarson and
J. B. Rattner and
Brian Burke Nup358 integrates nuclear envelope
breakdown with kinetochore assembly . . 991
Gohta Goshima and
Ronald D. Vale The roles of microtubule-based motor
proteins in mitosis . . . . . . . . . . 1003
Tim Raemaekers and
Katharina Ribbeck and
Joël Beaudouin and
Wim Annaert and
Mark Van Camp and
Ingrid Stockmans and
Nico Smets and
Roger Bouillon and
Jan Ellenberg and
Geert Carmeliet NuSAP, a novel microtubule-associated
protein involved in mitotic spindle
organization . . . . . . . . . . . . . . 1017
Markus Rehm and
Heiko Düßmann and
Jochen H. M. Prehn Real-time single cell analysis of
Smac/DIABLO release during apoptosis . . 1031
Takao Nakata and
Nobutaka Hirokawa Microtubules provide directional cues
for polarized axonal transport through
interaction with kinesin motor head . . 1045
Ryan E. Mudry and
Cynthia N. Perry and
Meredith Richards and
Velia M. Fowler and
Carol C. Gregorio The interaction of tropomodulin with
tropomyosin stabilizes thin filaments in
cardiac myocytes . . . . . . . . . . . . 1057
Gregory M. Guild and
Patricia S. Connelly and
Linda Ruggiero and
Kelly A. Vranich and
Lewis G. Tilney Long continuous actin bundles in
\bionameDrosophila bristles are
constructed by overlapping short
filaments . . . . . . . . . . . . . . . 1069
Stephen L. Rogers and
Ursula Wiedemann and
Nico Stuurman and
Ronald D. Vale Molecular requirements for actin-based
lamella formation in \bionameDrosophila
S2 cells . . . . . . . . . . . . . . . . 1079
Victoria C. Foletta and
Mei Ann Lim and
Juliana Soosairajah and
April P. Kelly and
Edouard G. Stanley and
Mark Shannon and
Wei He and
Supratik Das and
Joan Massagué and
Ora Bernard Direct signaling by the BMP type II
receptor via the cytoskeletal regulator
LIMK1 . . . . . . . . . . . . . . . . . 1089
Frantisek Sandor and
Eicke Latz and
Fabio Re and
Leisa Mandell and
Galina Repik and
Douglas T. Golenbock and
Terje Espevik and
Evelyn A. Kurt-Jones and
Robert W. Finberg Importance of extra- and intracellular
domains of TLR1 and TLR2 in NF$ \kappa
$B signaling . . . . . . . . . . . . . . 1099
Anna Cattelino and
Stefan Liebner and
Radiosa Gallini and
Adriana Zanetti and
Giovanna Balconi and
Alessandro Corsi and
Paolo Bianco and
Hartwig Wolburg and
Robert Moore and
Boussadia Oreda and
Rolf Kemler and
Elisabetta Dejana The conditional inactivation of the $
\beta $-catenin gene in endothelial
cells causes a defective vascular
pattern and increased vascular fragility 1111
Bryony S. Wiseman and
Mark D. Sternlicht and
Leif R. Lund and
Caroline M. Alexander and
Joni Mott and
Mina J. Bissell and
Paul Soloway and
Shigeyoshi Itohara and
Zena Werb Site-specific inductive and inhibitory
activities of MMP-2 and MMP-3
orchestrate mammary gland branching
morphogenesis . . . . . . . . . . . . . 1123
Seumas McCroskery and
Mark Thomas and
Linda Maxwell and
Mridula Sharma and
Ravi Kambadur Myostatin negatively regulates satellite
cell activation and self-renewal . . . . 1135
Sebastian Poliak and
Daniela Salomon and
Hadas Elhanany and
Helena Sabanay and
Brent Kiernan and
Larysa Pevny and
Colin L. Stewart and
Xiaorong Xu and
Shing-Yan Chiu and
Peter Shrager and
Andrew J. W. Furley and
Elior Peles Juxtaparanodal clustering of Shaker-like
K$^+$ channels in myelinated axons
depends on Caspr2 and TAG-1 . . . . . . 1149
Maria Traka and
Laurence Goutebroze and
Natalia Denisenko and
Maria Bessa and
Artemisia Nifli and
Sophia Havaki and
Yoichiro Iwakura and
Fumihiko Fukamauchi and
Kazutada Watanabe and
Betty Soliven and
Jean-Antoine Girault and
Domna Karagogeos Association of TAG-1 with Caspr2 is
essential for the molecular organization
of juxtaparanodal regions of myelinated
fibers . . . . . . . . . . . . . . . . . 1161
Alan W. Dove Getting lamin B1 processed and organized ??
Alan W. Dove How to block botox . . . . . . . . . . . ??
Alan W. Dove NgCAM takes a scenic route to the axon ??
Alan W. Dove A long version of Short stop . . . . . . ??
Alan W. Dove Pop goes the acrosome . . . . . . . . . ??
Nicole LeBrasseur Evolution steps back . . . . . . . . . . ??
Nicole LeBrasseur Translocon . . . . . . . . . . . . . . . ??
Nicole LeBrasseur Centrosomes lead stem cell orientation ??
Nicole LeBrasseur Grow wings for a limited time only . . . ??
Nicole LeBrasseur Keratin for supple cells . . . . . . . . ??
Jennifer H. Shin and
L. Mahadevan and
Guillermina S. Waller and
Knut Langsetmo and
Paul Matsudaira Stored elastic energy powers the 60-$
\mu $ m extension of the Limulus
polyphemus sperm actin bundle . . . . . 1183
Laurent Gagnoux-Palacios and
Michael Dans and
Wouter van't Hof and
Agnese Mariotti and
Angela Pepe and
Guerrino Meneguzzi and
Marilyn D. Resh and
Filippo G. Giancotti Compartmentalization of integrin $
\alpha $6$ \beta $4 signaling in lipid
rafts . . . . . . . . . . . . . . . . . 1189
Albert R. Davalos and
Judith Campisi Bloom syndrome cells undergo
p53-dependent apoptosis and delayed
assembly of BRCA1 and NBS1 repair
complexes at stalled replication forks 1197
John V. Kilmartin Sfi1p has conserved centrin-binding
sites and an essential function in
budding yeast spindle pole body
duplication . . . . . . . . . . . . . . 1211
Christopher P. Maske and
Michael S. Hollinshead and
Niall C. Higbee and
Martin O. Bergo and
Stephen G. Young and
David J. Vaux A carboxyl-terminal interaction of lamin
B1 is dependent on the CAAX endoprotease
Rce1 and carboxymethylation . . . . . . 1223
Daniel R. Larson and
Yu May Ma and
Volker M. Vogt and
Watt W. Webb Direct measurement of Gag--Gag
interaction during retrovirus assembly
with FRET and fluorescence correlation
spectroscopy . . . . . . . . . . . . . . 1233
Misty Moore and
Robyn L. Goforth and
Hiroki Mori and
Ralph Henry Functional interaction of chloroplast
SRP/FtsY with the ALB3 translocase in
thylakoids . . . . . . . . . . . . . . . 1245
Tong Guo and
Yuriy Y. Kit and
Jean-Marc Nicaud and
Marie-Therese Le Dall and
S. Kelly Sears and
Hojatollah Vali and
Honey Chan and
Richard A. Rachubinski and
Vladimir I. Titorenko Peroxisome division in the yeast
\bionameYarrowia lipolytica is regulated
by a signal from inside the peroxisome 1255
Jorge Santos Da Silva and
Miguel Medina and
Cecilia Zuliani and
Alessia Di Nardo and
Walter Witke and
Carlos G. Dotti RhoA/ROCK regulation of neuritogenesis
via profilin IIa-mediated control of
actin stability . . . . . . . . . . . . 1267
Hui Miao and
Christian H. Nickel and
Lloyd G. Cantley and
Leslie A. Bruggeman and
Laura N. Bennardo and
Bingcheng Wang EphA kinase activation regulates
HGF-induced epithelial branching
morphogenesis . . . . . . . . . . . . . 1281
Min Dong and
David A. Richards and
Michael C. Goodnough and
William H. Tepp and
Eric A. Johnson and
Edwin R. Chapman Synaptotagmins I and II mediate entry of
botulinum neurotoxin B into cells . . . 1293
Katja Röper and
Nicholas H. Brown Maintaining epithelial integrity . . . . 1305
Dolora Wisco and
Eric D. Anderson and
Michael C. Chang and
Caren Norden and
Tatiana Boiko and
Heike Fölsch and
Bettina Winckler Uncovering multiple axonal targeting
pathways in hippocampal neurons . . . . 1317
Nicole LeBrasseur Heparin sustains the brain . . . . . . . ??
Nicole LeBrasseur Recycling endosomes . . . . . . . . . . ??
Nicole LeBrasseur To kill a brain cell . . . . . . . . . . ??
Nicole LeBrasseur Integrin is on uPAR to unleash cells . . ??
Nicole LeBrasseur Choreographing telomeres . . . . . . . . ??
William A. Wells One crossover is enough . . . . . . . . ??
William A. Wells The sex--love connection . . . . . . . . ??
William A. Wells Prions by activation not amyloid . . . . ??
William A. Wells Neurons that swell . . . . . . . . . . . ??
William A. Wells Ready to replicate? So vesiculate! . . . ??
Oscar Fernandez-Capetillo and
Bodo Liebe and
Harry Scherthan and
André Nussenzweig H2AX regulates meiotic telomere
clustering . . . . . . . . . . . . . . . 15
Xinrong Fu and
Christine Ng and
Daorong Feng and
Chun Liang Cdc48p is required for the cell cycle
commitment point at Start via
degradation of the G1-CDK inhibitor
Far1p . . . . . . . . . . . . . . . . . 21
Yuzhi Chen and
Wenyun Liu and
Donna L. McPhie and
Linda Hassinger and
Rachael L. Neve APP-BP1 mediates APP-induced apoptosis
and DNA synthesis and is increased in
Alzheimer's disease brain . . . . . . . 27
Gottfried Eisner and
Hans-Georg Koch and
Konstanze Beck and
Joseph Brunner and
Matthias Müller Ligand crowding at a nascent signal
sequence . . . . . . . . . . . . . . . . 35
Masato Yano and
Kazutoyo Terada and
Masataka Mori AIP is a mitochondrial import mediator
that binds to both import receptor Tom20
and preproteins . . . . . . . . . . . . 45
Matthew Heidtman and
Catherine Z. Chen and
Ruth N. Collins and
Charles Barlowe A role for Yip1p in COPII vesicle
biogenesis . . . . . . . . . . . . . . . 57
Ssang-Goo Cho and
Jin Woo Kim and
Yong Hee Lee and
Hyun Sub Hwang and
Mi-Sung Kim and
Kanghyun Ryoo and
Myung Jin Kim and
Kyung Tae Noh and
Eun Kyung Kim and
Jun-Ho Cho and
Kyoung Wan Yoon and
Eun-Gyung Cho and
Hee-Sae Park and
Sung Wook Chi and
Min-Jae Lee and
Sang Sun Kang and
Hidenori Ichijo and
Eui-Ju Choi Identification of a novel antiapoptotic
protein that antagonizes ASK1 and CAD
activities . . . . . . . . . . . . . . . 71
Ming-Sum Lee and
Shih-Chu Kao and
Cynthia A. Lemere and
Weiming Xia and
Huang-Chun Tseng and
Ying Zhou and
Rachael Neve and
Michael K. Ahlijanian and
Li-Huei Tsai APP processing is regulated by
cytoplasmic phosphorylation . . . . . . 83
Zoe Scholefield and
Edwin A. Yates and
Gareth Wayne and
Augustin Amour and
William McDowell and
Jeremy E. Turnbull Heparan sulfate regulates amyloid
precursor protein processing by BACE1,
the Alzheimer's $ \beta $-secretase . . 97
Hui Zhou and
Fengli Cao and
Zhishan Wang and
Zhao-Xue Yu and
Huu-Phuc Nguyen and
Joy Evans and
Shi-Hua Li and
Xiao-Jiang Li Huntingtin forms toxic NH$_2$-terminal
fragment complexes that are promoted by
the age-dependent decrease in proteasome
activity . . . . . . . . . . . . . . . . 109
Nancy A. Rice and
Leslie A. Leinwand Skeletal myosin heavy chain function in
cultured lung myofibroblasts . . . . . . 119
Stanislav Samarin and
Stéphane Romero and
Christine Kocks and
Dominique Didry and
Dominique Pantaloni and
Marie-France Carlier How VASP enhances actin-based motility 131
Blake Riggs and
Wendy Rothwell and
Sarah Mische and
Gilles R. X. Hickson and
Johanne Matheson and
Thomas S. Hays and
Gwyn W. Gould and
William Sullivan Actin cytoskeleton remodeling during
early \bionameDrosophila furrow
formation requires recycling endosomal
components Nuclear-fallout and Rab11 . . 143
Fernando Martín-Belmonte and
José A. Martínez-Menárguez and
Juan F. Aranda and
José Ballesta and
María C. de Marco and
Miguel A. Alonso MAL regulates clathrin-mediated
endocytosis at the apical surface of
Madin--Darby canine kidney cells . . . . 155
Masaki Shigeta and
Noriko Sanzen and
Masayuki Ozawa and
Jianguo Gu and
Hitoshi Hasegawa and
Kiyotoshi Sekiguchi CD151 regulates epithelial cell--cell
adhesion through PKC- and
Cdc42-dependent actin cytoskeletal
reorganization . . . . . . . . . . . . . 165
Feng Zhang and
Clifford C. Tom and
Matthias C. Kugler and
Tsui-Ting Ching and
Jordan A. Kreidberg and
Ying Wei and
Harold A. Chapman Distinct ligand binding sites in
integrin $ \alpha $3$ \beta $1 regulate
matrix adhesion and cell--cell contact 177
Alan W. Dove Weaklings unite to reorganize cell . . . ??
Alan W. Dove Getting specific about polarized sorting ??
Alan W. Dove An early warning system for DNA damage ??
Alan W. Dove A close look at cerebellar learning . . ??
Alan W. Dove Laminin-2 on the brain . . . . . . . . . ??
Nicole LeBrasseur Desmosomes in a tangle . . . . . . . . . ??
Nicole LeBrasseur Flies fight famine . . . . . . . . . . . ??
Nicole LeBrasseur The kinase knows . . . . . . . . . . . . ??
Nicole LeBrasseur Transcription keeps it simple . . . . . ??
Nicole LeBrasseur Binding takes cooperation . . . . . . . ??
Linton M. Traub Sorting it out . . . . . . . . . . . . . 203
Michael S. Pepper and
Mihaela Skobe Lymphatic endothelium . . . . . . . . . 209
Stefan Westermann and
Iain M. Cheeseman and
Scott Anderson and
John R. Yates and
David G. Drubin and
Georjana Barnes Architecture of the budding yeast
kinetochore reveals a conserved
molecular core . . . . . . . . . . . . . 215
Jia-Jia Liu and
Jianqing Ding and
Anthony S. Kowal and
Timothy Nardine and
Elizabeth Allen and
Jean-Dominique Delcroix and
Chengbiao Wu and
William Mobley and
Elaine Fuchs and
Yanmin Yang BPAG1n4 is essential for retrograde
axonal transport in sensory neurons . . 223
Antony P. Jackson and
Alexander Flett and
Carl Smythe and
Lindsay Hufton and
Frank R. Wettey and
Elizabeth Smythe Clathrin promotes incorporation of cargo
into coated pits by activation of the
AP2 adaptor $ \mu $2 kinase . . . . . . 231
Patricia S. Bilodeau and
Stanley C. Winistorfer and
William R. Kearney and
Andrew D. Robertson and
Robert C. Piper Vps27-Hse1 and ESCRT--I complexes
cooperate to increase efficiency of
sorting ubiquitinated proteins at the
endosome . . . . . . . . . . . . . . . . 237
Matthew P. Stokes and
W. Matthew Michael DNA damage-induced replication arrest in
\bionameXenopus egg extracts . . . . . . 245
Erik L. Snapp and
Ramanujan S. Hegde and
Maura Francolini and
Francesca Lombardo and
Sara Colombo and
Emanuela Pedrazzini and
Nica Borgese and
Jennifer Lippincott-Schwartz Formation of stacked ER cisternae by low
affinity protein interactions . . . . . 257
Julia V. Gerasimenko and
Yoshio Maruyama and
Kojiro Yano and
Nick J. Dolman and
Alexei V. Tepikin and
Ole H. Petersen and
Oleg V. Gerasimenko NAADP mobilizes Ca$^{2+}$ from a
thapsigargin-sensitive store in the
nuclear envelope by activating ryanodine
receptors . . . . . . . . . . . . . . . 271
Natalia Cheshenko and
Brian Del Rosario and
Craig Woda and
Daniel Marcellino and
Lisa M. Satlin and
Betsy C. Herold Herpes simplex virus triggers activation
of calcium-signaling pathways . . . . . 283
Robert Feil and
Jana Hartmann and
Chongde Luo and
Wiebke Wolfsgruber and
Karl Schilling and
Susanne Feil and
Jaroslaw J. Barski and
Michael Meyer and
Arthur Konnerth and
Chris I. De Zeeuw and
Franz Hofmann Impairment of LTD and cerebellar
learning by Purkinje cell--specific
ablation of cGMP-dependent protein
kinase I . . . . . . . . . . . . . . . . 295
Silvia Parisi and
Daniela D'Andrea and
Carmine T. Lago and
Eileen D. Adamson and
M. Graziella Persico and
Gabriella Minchiotti Nodal-dependent Cripto signaling
promotes cardiomyogenesis and redirects
the neural fate of embryonic stem cells 303
Jayanta Debnath and
Stephanie J. Walker and
Joan S. Brugge Akt activation disrupts mammary acinar
architecture and enhances proliferation
in an mTOR-dependent manner . . . . . . 315
Pauline Wong and
Pierre A. Coulombe Loss of keratin 6 (K6) proteins reveals
a function for intermediate filaments
during wound repair . . . . . . . . . . 327
Agnes Lee Ang and
Heike Fölsch and
Ulla-Maija Koivisto and
Marc Pypaert and
Ira Mellman The Rab8 GTPase selectively regulates
AP-1B-dependent basolateral transport in
polarized Madin--Darby canine kidney
cells . . . . . . . . . . . . . . . . . 339
Heike Fölsch and
Marc Pypaert and
Sandra Maday and
Laurence Pelletier and
Ira Mellman The AP-1A and AP-1B clathrin adaptor
complexes define biochemically and
functionally distinct membrane domains 351
Charles J. Russell and
Karen L. Kantor and
Theodore S. Jardetzky and
Robert A. Lamb A dual-functional paramyxovirus F
protein regulatory switch segment . . . 363
Yong-Kook Kwon and
Hyeung-Jin Jang and
Sutapa Kole and
Hua-Jun He and
Michel Bernier Role of the pleckstrin homology domain
of PLC$ \gamma $1 in its interaction
with the insulin receptor . . . . . . . 375
Jing Du and
Linyin Feng and
Eugene Zaitsev and
Hyun-Soo Je and
Xu-wen Liu and
Bai Lu Regulation of TrkB receptor tyrosine
kinase and its internalization by
neuronal activity and Ca$^{2+}$ influx 385
Soo Jin Chun and
Matthew N. Rasband and
Richard L. Sidman and
Amyn A. Habib and
Timothy Vartanian Integrin-linked kinase is required for
laminin-$2$--induced oligodendrocyte
cell spreading and CNS myelination . . . 397
Grégory Giannone and
Guoying Jiang and
Deborah H. Sutton and
David R. Critchley and
Michael P. Sheetz Talin1 is critical for force-dependent
reinforcement of initial
integrin--cytoskeleton bonds but not
tyrosine kinase activation . . . . . . . 409
Nicole LeBrasseur BMP in a hairy situation . . . . . . . . ??
Nicole LeBrasseur ROCK and Rho in $3$D . . . . . . . . . . ??
Nicole LeBrasseur Where mtDNA is made . . . . . . . . . . ??
Nicole LeBrasseur Forcing cells to stick around . . . . . ??
Nicole LeBrasseur Quick cartilage transformation . . . . . ??
William A. Wells Passing along polarity . . . . . . . . . ??
William A. Wells A kinase that activates by occupancy . . ??
William A. Wells How to renew a stem cell . . . . . . . . ??
William A. Wells Latching onto fibrinogen . . . . . . . . ??
William A. Wells Damage first; infect later . . . . . . . ??
Mark Peifer and
Alpha S. Yap Traffic control . . . . . . . . . . . . 437
Rosario Rizzuto Calcium mobilization from mitochondria
in synaptic transmitter release . . . . 441
Ronald D. Vale Myosin V motor proteins . . . . . . . . 445
Eileen T. O'Toole and
Kent L. McDonald and
Jana Mäntler and
J. Richard McIntosh and
Anthony A. Hyman and
Thomas Müller-Reichert Morphologically distinct microtubule
ends in the mitotic centrosome of
\bionameCaenorhabditis elegans . . . . . 451
Brett A. Kaufman and
Jill E. Kolesar and
Philip S. Perlman and
Ronald A. Butow A function for the mitochondrial
chaperonin Hsp60 in the structure and
transmission of mitochondrial DNA
nucleoids in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 457
Tiziana Bisogno and
Fiona Howell and
Gareth Williams and
Alberto Minassi and
Maria Grazia Cascio and
Alessia Ligresti and
Isabel Matias and
Aniello Schiano-Moriello and
Praveen Paul and
Emma-Jane Williams and
Uma Gangadharan and
Carl Hobbs and
Vincenzo Di Marzo and
Patrick Doherty Cloning of the first sn1-DAG lipases
points to the spatial and temporal
regulation of endocannabinoid signaling
in the brain . . . . . . . . . . . . . . 463
Satoru Yamazaki and
Ryo Iwamoto and
Kazuko Saeki and
Masanori Asakura and
Seiji Takashima and
Ayano Yamazaki and
Rina Kimura and
Hiroto Mizushima and
Hiroki Moribe and
Shigeki Higashiyama and
Masayuki Endoh and
Yasufumi Kaneda and
Satoshi Takagi and
Satoshi Itami and
Naoki Takeda and
Gen Yamada and
Eisuke Mekada Mice with defects in HB--EGF ectodomain
shedding show severe developmental
abnormalities . . . . . . . . . . . . . 469
Yoshiaki Azuma and
Alexei Arnaoutov and
Mary Dasso SUMO-2\slash 3 regulates topoisomerase
II in mitosis . . . . . . . . . . . . . 477
Daisuke Nanba and
Akiko Mammoto and
Koji Hashimoto and
Shigeki Higashiyama Proteolytic release of the
carboxy-terminal fragment of proHB--EGF
causes nuclear export of PLZF . . . . . 489
Shelly Meeusen and
Jodi Nunnari Evidence for a two membrane--spanning
autonomous mitochondrial DNA replisome 503
Feng Yang and
Xiang-ping He and
James Russell and
Bai Lu Ca$^{2+}$ influx-independent synaptic
potentiation mediated by mitochondrial
Na$^+$--Ca$^{2+}$ exchanger and protein
kinase C . . . . . . . . . . . . . . . . 511
Michael A. Davis and
Renee C. Ireton and
Albert B. Reynolds A core function for p120-catenin in
cadherin turnover . . . . . . . . . . . 525
Kanyan Xiao and
David F. Allison and
Kathleen M. Buckley and
Margaret D. Kottke and
Peter A. Vincent and
Victor Faundez and
Andrew P. Kowalczyk Cellular levels of p120 catenin function
as a set point for cadherin expression
levels in microvascular endothelial
cells . . . . . . . . . . . . . . . . . 535
Xinyu Chen and
Shin-ichiro Kojima and
Gary G. Borisy and
Kathleen J. Green p120 catenin associates with kinesin and
facilitates the transport of
cadherin--catenin complexes to
intercellular junctions . . . . . . . . 547
Claire Desnos and
Jean-Sébastien Schonn and
Sébastien Huet and
Viet Samuel Tran and
Aziz El-Amraoui and
Graça Raposo and
Isabelle Fanget and
Catherine Chapuis and
Gaël Ménasché and
Genevi\`eve de Saint Basile and
Christine Petit and
Sophie Cribier and
Jean-Pierre Henry and
François Darchen Rab27A and its effector MyRIP link
secretory granules to F-actin and
control their motion towards release
sites . . . . . . . . . . . . . . . . . 559
Ling Su and
Joyce M. Agati and
Sarah J. Parsons p190RhoGAP is cell cycle regulated and
affects cytokinesis . . . . . . . . . . 571
Michele A. Wozniak and
Radhika Desai and
Patricia A. Solski and
Channing J. Der and
Patricia J. Keely ROCK-generated contractility regulates
breast epithelial cell differentiation
in response to the physical properties
of a three-dimensional collagen matrix 583
Lai-Wa Tam and
William L. Dentler and
Paul A. Lefebvre Defective flagellar assembly and length
regulation in LF3 null mutants in
Chlamydomonas . . . . . . . . . . . . . 597
Krzysztof Kobielak and
H. Amalia Pasolli and
Laura Alonso and
Lisa Polak and
Elaine Fuchs Defining BMP functions in the hair
follicle by conditional ablation of BMP
receptor IA . . . . . . . . . . . . . . 609
Bart De Cat and
Sin-Ya Muyldermans and
Christien Coomans and
Gis\`ele Degeest and
Bernadette Vanderschueren and
John Creemers and
Frédéric Biemar and
Bernard Peers and
Guido David Processing by proprotein convertases is
required for glypican-3 modulation of
cell survival, Wnt signaling, and
gastrulation movements . . . . . . . . . 625
Benjamin L. Allen and
Alan C. Rapraeger Spatial and temporal expression of
heparan sulfate in mouse development
regulates FGF and FGF receptor assembly 637
Oren Dwir and
Ariel Solomon and
Shmuel Mangan and
Geoffrey S. Kansas and
Ulrich S. Schwarz and
Ronen Alon Avidity enhancement of L-selectin bonds
by flow . . . . . . . . . . . . . . . . 649
Kenn Holmbeck and
Paolo Bianco and
Kali Chrysovergis and
Susan Yamada and
Henning Birkedal-Hansen MT1-MMP-dependent, apoptotic remodeling
of unmineralized cartilage . . . . . . . 661
William A. Wells Held back by a finger . . . . . . . . . ??
William A. Wells Cautious apoptosis . . . . . . . . . . . ??
William A. Wells A disease of actin transport? . . . . . ??
William A. Wells Notch gets transformed . . . . . . . . . ??
William A. Wells Barriers to export . . . . . . . . . . . ??
Nicole LeBrasseur Tearing down the spindle . . . . . . . . ??
Nicole LeBrasseur Receptors make a quick exit . . . . . . ??
Nicole LeBrasseur Immune cells take in unknown enemies . . ??
Nicole LeBrasseur Fold me or leave me . . . . . . . . . . ??
Nicole LeBrasseur Fusion gets in the groove . . . . . . . ??
Linda Wordeman Breathing down the neck of Unc104 . . . 693
Chan Nguyen and
James A. Bibb Cdk5 and the mystery of synaptic vesicle
endocytosis . . . . . . . . . . . . . . 697
Peggy Roth and
Nikos Xylourgidis and
Nafiseh Sabri and
Anne Uv and
Maarten Fornerod and
Christos Samakovlis The \bionameDrosophila nucleoporin
DNup88 localizes DNup214 and CRM1 on the
nuclear envelope and attenuates
NES-mediated nuclear export . . . . . . 701
Kaye N. Truscott and
Wolfgang Voos and
Ann E. Frazier and
Maria Lind and
Yanfeng Li and
Andreas Geissler and
Jan Dudek and
Hanne Müller and
Albert Sickmann and
Helmut E. Meyer and
Chris Meisinger and
Bernard Guiard and
Peter Rehling and
Nikolaus Pfanner A J-protein is an essential subunit of
the presequence translocase--associated
protein import motor of mitochondria . . 707
Dermott W. O'Callaghan and
Alexei V. Tepikin and
Robert D. Burgoyne Dynamics and calcium sensitivity of the
Ca$^{2+}$ /myristoyl switch protein
hippocalcin in living cells . . . . . . 715
Andries Blokzijl and
Camilla Dahlqvist and
Eva Reissmann and
Anna Falk and
Annalena Moliner and
Urban Lendahl and
Carlos F. Ibáñez Cross-talk between the Notch and TGF-$
\beta $ signaling pathways mediated by
interaction of the Notch intracellular
domain with Smad3 . . . . . . . . . . . 723
Kristen Stead and
Cristina Aguilar and
Theresa Hartman and
Melissa Drexel and
Pamela Meluh and
Vincent Guacci Pds5p regulates the maintenance of
sister chromatid cohesion and is
sumoylated to promote the dissolution of
cohesion . . . . . . . . . . . . . . . . 729
Jawdat Al-Bassam and
Yujia Cui and
Dieter Klopfenstein and
Bridget O. Carragher and
Ronald D. Vale and
Ronald A. Milligan Distinct conformations of the kinesin
Unc104 neck regulate a monomer to dimer
motor transition . . . . . . . . . . . . 743
Pradipta Ghosh and
Janice Griffith and
Hans J. Geuze and
Stuart Kornfeld Mammalian GGAs act together to sort
mannose $6$-phosphate receptors . . . . 755
Céline Jousse and
Seiichi Oyadomari and
Isabel Novoa and
Phoebe Lu and
Yuhong Zhang and
Heather P. Harding and
David Ron Inhibition of a constitutive translation
initiation factor 2$ \alpha $
phosphatase, CReP, promotes survival of
stressed cells . . . . . . . . . . . . . 767
Luigia Atorino and
Laura Silvestri and
Mirko Koppen and
Laura Cassina and
Andrea Ballabio and
Roberto Marconi and
Thomas Langer and
Giorgio Casari Loss of m--AAA protease in mitochondria
causes complex I deficiency and
increased sensitivity to oxidative
stress in hereditary spastic paraplegia 777
Patrick Ryan Potts and
Shweta Singh and
Malia Knezek and
Craig B. Thompson and
Mohanish Deshmukh Critical function of endogenous XIAP in
regulating caspase activation during
sympathetic neuronal apoptosis . . . . . 789
Wilfried Rossoll and
Sibylle Jablonka and
Catia Andreassi and
Ann-Kathrin Kröning and
Kathrin Karle and
Umrao R. Monani and
Michael Sendtner Smn, the spinal muscular
atrophy--determining gene product,
modulates axon growth and localization
of $ \beta $-actin mRNA in growth cones
of motoneurons . . . . . . . . . . . . . 801
Kazuhito Tomizawa and
Satoshi Sunada and
Yun-Fei Lu and
Yoshiya Oda and
Masahiro Kinuta and
Toshio Ohshima and
Taro Saito and
Fan-Yan Wei and
Masayuki Matsushita and
Sheng-Tian Li and
Kimiko Tsutsui and
Shin-ichi Hisanaga and
Katsuhiko Mikoshiba and
Kohji Takei and
Hideki Matsui Cophosphorylation of amphiphysin I and
dynamin I by Cdk5 regulates
clathrin-mediated endocytosis of
synaptic vesicles . . . . . . . . . . . 813
Masakiyo Sakaguchi and
Masahiro Miyazaki and
Mikiro Takaishi and
Yoshihiko Sakaguchi and
Eiichi Makino and
Noriyuki Kataoka and
Hidenori Yamada and
Masayoshi Namba and
Nam-ho Huh S100C\slash A11 is a key mediator of
Ca$^{2+}$-induced growth inhibition of
human epidermal keratinocytes . . . . . 825
Santina Bruzzone and
Svenja Kunerth and
Elena Zocchi and
Antonio De Flora and
Andreas H. Guse Spatio-temporal propagation of Ca$^{2+}$
signals by cyclic ADP-ribose in 3T3
cells stimulated via purinergic P2Y
receptors . . . . . . . . . . . . . . . 837
Maralice Conacci-Sorrell and
Inbal Simcha and
Tamar Ben-Yedidia and
Janna Blechman and
Pierre Savagner and
Avri Ben-Ze'ev Autoregulation of E-cadherin expression
by cadherin--cadherin interactions . . . 847
Ayse G. Kayali and
Kurt Van Gunst and
Iain L. Campbell and
Aleksandr Stotland and
Marcie Kritzik and
Guoxun Liu and
Malin Flodström-Tullberg and
You-Qing Zhang and
Nora Sarvetnick The stromal cell--derived factor-1$
\alpha $/CXCR4 ligand--receptor axis is
critical for progenitor survival and
migration in the pancreas . . . . . . . 859
Sven Christian and
Jan Pilch and
Maria E. Akerman and
Kimmo Porkka and
Pirjo Laakkonen and
Erkki Ruoslahti Nucleolin expressed at the cell surface
is a marker of endothelial cells in
angiogenic blood vessels . . . . . . . . 871
Dmitry E. Shvartsman and
Mariana Kotler and
Renee D. Tall and
Michael G. Roth and
Yoav I. Henis Differently anchored influenza
hemagglutinin mutants display distinct
interaction dynamics with mutual rafts 879
Zu-Lin Chen and
Sidney Strickland Laminin $ \gamma $1 is critical for
Schwann cell differentiation, axon
myelination, and regeneration in the
peripheral nerve . . . . . . . . . . . . 889
Karin List and
Roman Szabo and
Philip W. Wertz and
Julie Segre and
Christian C. Haudenschild and
Soo-Youl Kim and
Thomas H. Bugge Loss of proteolytically processed
filaggrin caused by epidermal deletion
of Matriptase/MT-SP1 . . . . . . . . . . 901
Nicole LeBrasseur Fewer phosphates but fatter axons . . . ??
Nicole LeBrasseur The APC--tumor connection . . . . . . . ??
Nicole LeBrasseur Neurons die one way or another . . . . . ??
Nicole LeBrasseur Fusion fuels killing . . . . . . . . . . ??
Nicole LeBrasseur Tearing down actin . . . . . . . . . . . ??
William A. Wells Managing tension . . . . . . . . . . . . ??
William A. Wells Civil war in the immune system . . . . . ??
William A. Wells Catenin keeps vesicles close . . . . . . ??
William A. Wells S is for sticky . . . . . . . . . . . . ??
William A. Wells Worms delay in deep sleep . . . . . . . ??
Ebru Erbay and
In-Hyun Park and
Paul D. Nuzzi and
Christopher J. Schoenherr and
Jie Chen IGF-II transcription in skeletal
myogenesis is controlled by mTOR and
nutrients . . . . . . . . . . . . . . . 931
Hong-Guo Yu and
Douglas E. Koshland Meiotic condensin is required for proper
chromosome compaction, SC assembly, and
resolution of recombination-dependent
chromosome linkages . . . . . . . . . . 937
Rebecca A. Green and
Kenneth B. Kaplan Chromosome instability in colorectal
tumor cells is associated with defects
in microtubule plus-end attachments
caused by a dominant mutation in APC . . 949
Carolyn A. Moores and
Mohammad Hekmat-Nejad and
Roman Sakowicz and
Ronald A. Milligan Regulation of KinI kinesin ATPase
activity by binding to the microtubule
lattice . . . . . . . . . . . . . . . . 963
Chao-Wen Wang and
Per E. Stromhaug and
Emily J. Kauffman and
Lois S. Weisman and
Daniel J. Klionsky Yeast homotypic vacuole fusion requires
the Ccz1--Mon1 complex during the
tethering/docking stage . . . . . . . . 973
Li-Ying Yu and
Eija Jokitalo and
Yun-Fu Sun and
Patrick Mehlen and
Dan Lindholm and
Mart Saarma and
Urmas Arumäe GDNF-deprived sympathetic neurons die
via a novel nonmitochondrial pathway . . 987
H. Nicholas Marsh and
Catherine I. Dubreuil and
Celia Quevedo and
Anna Lee and
Marta Majdan and
Gregory S. Walsh and
Sharon Hausdorff and
Farid Arab Said and
Olga Zoueva and
Maya Kozlowski and
Katherine Siminovitch and
Benjamin G. Neel and
Freda D. Miller and
David R. Kaplan SHP-1 negatively regulates neuronal
survival by functioning as a TrkA
phosphatase . . . . . . . . . . . . . . 999
Michael L. Garcia and
Christian S. Lobsiger and
Sameer B. Shah and
Tom J. Deerinck and
John Crum and
Darren Young and
Christopher M. Ward and
Thomas O. Crawford and
Takahiro Gotow and
Yasuo Uchiyama and
Mark H. Ellisman and
Nigel A. Calcutt and
Don W. Cleveland NF-M is an essential target for the
myelin-directed ``outside-in'' signaling
cascade that mediates radial axonal
growth . . . . . . . . . . . . . . . . . 1011
Mala V. Rao and
Jabbar Campbell and
Aidong Yuan and
Asok Kumar and
Takahiro Gotow and
Yasuo Uchiyama and
Ralph A. Nixon The neurofilament middle molecular mass
subunit carboxyl-terminal tail domains
is essential for the radial growth and
cytoskeletal architecture of axons but
not for regulating neurofilament
transport rate . . . . . . . . . . . . . 1021
Kimberly L. Fritz-Six and
Patrick R. Cox and
Robert S. Fischer and
Bisong Xu and
Carol C. Gregorio and
Huda Y. Zoghbi and
Velia M. Fowler Aberrant myofibril assembly in
tropomodulin1 null mice leads to aborted
heart development and embryonic
lethality . . . . . . . . . . . . . . . 1033
Patricia A. Loomis and
Lili Zheng and
Gabriella Sekerková and
Benjarat Changyaleket and
Enrico Mugnaini and
James R. Bartles Espin cross-links cause the elongation
of microvillus-type parallel actin
bundles in vivo . . . . . . . . . . . . 1045
Vitold E. Galkin and
Albina Orlova and
Margaret S. VanLoock and
Alexander Shvetsov and
Emil Reisler and
Edward H. Egelman ADF\slash cofilin use an intrinsic mode
of F-actin instability to disrupt actin
filaments . . . . . . . . . . . . . . . 1057
Mitsunobu Hoshino and
Shun Nakamura Small GTPase Rin induces neurite
outgrowth through Rac/Cdc42 and
calmodulin in PC12 cells . . . . . . . . 1067
Kazunari Nishimura and
Fumie Yoshihara and
Takuro Tojima and
Noriko Ooashi and
Woohyun Yoon and
Katsuhiko Mikoshiba and
Vann Bennett and
Hiroyuki Kamiguchi L1-dependent neuritogenesis involves
ankyrin$_B$ that mediates L1-CAM
coupling with retrograde actin flow . . 1077
Melissa M. Rolls and
Roger Albertson and
Hsin-Pei Shih and
Cheng-Yu Lee and
Chris Q. Doe Drosophila aPKC regulates cell polarity
and cell proliferation in neuroblasts
and epithelia . . . . . . . . . . . . . 1089
Erik-Jan Kamsteeg and
Daniel G. Bichet and
Irene B. M. Konings and
Hubert Nivet and
Michelle Lonergan and
Marie-Françoise Arthus and
Carel H. van Os and
Peter M. T. Deen Reversed polarized delivery of an
aquaporin-2 mutant causes dominant
nephrogenic diabetes insipidus . . . . . 1099
Magali Prigent and
Thierry Dubois and
Graça Raposo and
Valérie Derrien and
Dani\`ele Tenza and
Carine Rossé and
Jacques Camonis and
Philippe Chavrier ARF6 controls post-endocytic recycling
through its downstream exocyst complex
effector . . . . . . . . . . . . . . . . 1111
Lorraine D. Hernandez and
Marc Pypaert and
Richard A. Flavell and
Jorge E. Galán A Salmonella protein causes macrophage
cell death by inducing autophagy . . . . 1123
Bénédicte Chazaud and
Corinne Sonnet and
Peggy Lafuste and
Guillaume Bassez and
Anne-Cécile Rimaniol and
Françoise Poron and
François-Jérôme Authier and
Patrick A. Dreyfus and
Romain K. Gherardi Satellite cells attract monocytes and
use macrophages as a support to escape
apoptosis and enhance muscle growth . . 1133
Boris Tchernychev and
Bruce Furie and
Barbara C. Furie Peritoneal macrophages express both
P-selectin and PSGL-1 . . . . . . . . . 1145
Elsa-Noah N'Diaye and
Eric J. Brown The ubiquitin-related protein PLIC-1
regulates heterotrimeric G protein
function through association with G$
\beta \gamma $ . . . . . . . . . . . . . 1157
Christopher S. Stipp and
Tatiana V. Kolesnikova and
Martin E. Hemler EWI-2 regulates $ \alpha $3$ \beta $1
integrin-dependent cell functions on
laminin-5 . . . . . . . . . . . . . . . 1167
Alan W. Dove Math models morphogenesis and mitosis ??
Alan W. Dove Cup puts a lid and a handle on mRNA . . ??
Alan W. Dove Cells need backward motor to move
forward . . . . . . . . . . . . . . . . ??
Alan W. Dove Death and the shrinking nucleus . . . . ??
Alan W. Dove Neural progenitors find VEGF attractive ??
Nicole LeBrasseur Transcribed in synchronicity . . . . . . ??
Nicole LeBrasseur Auxin auxin everywhere . . . . . . . . . ??
Nicole LeBrasseur Eggs never forget . . . . . . . . . . . ??
Nicole LeBrasseur Calcium makes a fast getaway . . . . . . ??
Nicole LeBrasseur Knocked down a Notch with age . . . . . ??
Paul Lasko Cup-ling oskar RNA localization and
translational control . . . . . . . . . 1189
Wolfgang Wagner and
John A. Hammer Myosin V and the endoplasmic reticulum 1193
James E. Wilhelm and
Meredith Hilton and
Quinlan Amos and
William J. Henzel Cup is an eIF4E binding protein required
for both the translational repression of
oskar and the recruitment of Barentsz 1197
Denis L. Dujardin and
Lora E. Barnhart and
Stephanie A. Stehman and
Edgar R. Gomes and
Gregg G. Gundersen and
Richard B. Vallee A role for cytoplasmic dynein and LIS1
in directed cell movement . . . . . . . 1205
Leora Gollan and
Daniela Salomon and
James L. Salzer and
Elior Peles Caspr regulates the processing of
contactin and inhibits its binding to
neurofascin . . . . . . . . . . . . . . 1213
Koei Shinzawa and
Yoshihide Tsujimoto PLA$_2$ activity is required for nuclear
shrinkage in caspase-independent cell
death . . . . . . . . . . . . . . . . . 1219
Brian J. Tunquist and
Patrick A. Eyers and
Lin G. Chen and
Andrea L. Lewellyn and
James L. Maller Spindle checkpoint proteins Mad1 and
Mad2 are required for cytostatic
factor--mediated metaphase arrest . . . 1231
Andrea Ciliberto and
Bela Novak and
John J. Tyson Mathematical model of the morphogenesis
checkpoint in budding yeast . . . . . . 1243
Paula Estrada and
Jiwon Kim and
Jeff Coleman and
Lee Walker and
Brian Dunn and
Peter Takizawa and
Peter Novick and
Susan Ferro-Novick Myo4p and She3p are required for
cortical ER inheritance in
\bionameSaccharomyces cerevisiae . . . . 1255
Elizabeth E. Grevengoed and
Donald T. Fox and
Julie Gates and
Mark Peifer Balancing different types of actin
polymerization at distinct sites . . . . 1267
Katy Janvier and
Yukio Kato and
Markus Boehm and
Jeremy R. Rose and
José A. Martina and
Bong-Yoon Kim and
Sundararajan Venkatesan and
Juan S. Bonifacino Recognition of dileucine-based sorting
signals from HIV-1 Nef and LIMP--II by
the AP-1 $ \gamma $--$ \sigma $1 and
AP-3 $ \delta $--$ \sigma $3
hemicomplexes . . . . . . . . . . . . . 1281
Ali Nawshad and
Elizabeth D. Hay TGF$ \beta_3 $ signaling activates
transcription of the LEF1 gene to induce
epithelial mesenchymal transformation
during mouse palate development . . . . 1291
Tetsuro Watabe and
Ayako Nishihara and
Koichi Mishima and
Jun Yamashita and
Kiyoshi Shimizu and
Keiji Miyazawa and
Shin-Ichi Nishikawa and
Kohei Miyazono TGF-$ \beta $ receptor kinase inhibitor
enhances growth and integrity of
embryonic stem cell--derived endothelial
cells . . . . . . . . . . . . . . . . . 1303
Mark Henkemeyer and
Olga S. Itkis and
Michelle Ngo and
Peter W. Hickmott and
Iryna M. Ethell Multiple EphB receptor tyrosine kinases
shape dendritic spines in the
hippocampus . . . . . . . . . . . . . . 1313
Sabine Uhles and
Tilo Moede and
Barbara Leibiger and
Per-Olof Berggren and
Ingo B. Leibiger Isoform-specific insulin receptor
signaling involves different plasma
membrane domains . . . . . . . . . . . . 1327
Kun Ling and
Renee L. Doughman and
Vidhya V. Iyer and
Ari J. Firestone and
Shawn F. Bairstow and
Deane F. Mosher and
Michael D. Schaller and
Richard A. Anderson Tyrosine phosphorylation of type I$
\gamma $ phosphatidylinositol phosphate
kinase by Src regulates an
integrin--talin switch . . . . . . . . . 1339
Nibedita Chattopadhyay and
Zemin Wang and
Leonie K. Ashman and
Susann M. Brady-Kalnay and
Jordan A. Kreidberg $ \alpha $3$ \beta $1 integrin--CD151, a
component of the cadherin--catenin
complex, regulates PTP$ \mu $ expression
and cell--cell adhesion . . . . . . . . 1351
Marko Hyytiäinen and
Jorma Keski-Oja Latent TGF-$ \beta $ binding protein
LTBP-2 decreases fibroblast adhesion to
fibronectin . . . . . . . . . . . . . . 1363
Huanxiang Zhang and
Laszlo Vutskits and
Michael S. Pepper and
Jozsef Z. Kiss VEGF is a chemoattractant for
FGF-2--stimulated neural progenitors . . 1375
Hendra Setiadi and
Rodger P. McEver Signal-dependent distribution of cell
surface P-selectin in clathrin-coated
pits affects leukocyte rolling under
flow . . . . . . . . . . . . . . . . . . 1385
Nastaran Zahir and
Johnathon N. Lakins and
Alan Russell and
WenYu Ming and
Chandrima Chatterjee and
Gabriela I. Rozenberg and
M. Peter Marinkovich and
Valerie M. Weaver Autocrine laminin-5 ligates $ \alpha $6$
\beta $4 integrin and activates RAC and
NF$ \kappa $B to mediate
anchorage-independent survival of
mammary tumors . . . . . . . . . . . . . 1397
Nicole LeBrasseur Heart-shaped clones . . . . . . . . . . ??
Nicole LeBrasseur Membrane fusion SNAREs an inhibitor . . ??
Nicole LeBrasseur Awakening heterochromatin . . . . . . . ??
Nicole LeBrasseur Malaria protease takes an indirect route ??
Nicole LeBrasseur Calcium pumps need a chaperone . . . . . ??
William A. Wells Protein translocation pulls the plug . . ??
William A. Wells A circular uncoating mechanism . . . . . ??
William A. Wells Giving neural precursors the finger . . ??
William A. Wells Formin' adherens junctions . . . . . . . ??
William A. Wells Oxidation makes a germline . . . . . . . ??
Mike Rossner and
Rob O'Donnell The JCB will let your data shine in RGB 11
Anton Sandqvist and
Lea Sistonen Nuclear stress granules . . . . . . . . 15
Ian Gentle and
Kipros Gabriel and
Peter Beech and
Ross Waller and
Trevor Lithgow The Omp85 family of proteins is
essential for outer membrane biogenesis
in mitochondria and bacteria . . . . . . 19
Caroline Jolly and
Alexandra Metz and
Jérôme Govin and
Marc Vigneron and
Bryan M. Turner and
Saadi Khochbin and
Claire Vourc'h Stress-induced transcription of
satellite III repeats . . . . . . . . . 25
Yun Li and
Patricia Camacho Ca$^{2+}$-dependent redox modulation of
SERCA 2b by ERp57 . . . . . . . . . . . 35
Michael Klemba and
Wandy Beatty and
Ilya Gluzman and
Daniel E. Goldberg Trafficking of plasmepsin II to the food
vacuole of the malaria parasite
Plasmodium falciparum . . . . . . . . . 47
Jacob M. Jones and
James C. Morrell and
Stephen J. Gould PEX19 is a predominantly cytosolic
chaperone and import receptor for class
1 peroxisomal membrane proteins . . . . 57
Anne G. Ostermeyer and
Lynne T. Ramcharan and
Youchun Zeng and
Douglas M. Lublin and
Deborah A. Brown Role of the hydrophobic domain in
targeting caveolin-1 to lipid droplets 69
Oleg Varlamov and
Allen Volchuk and
Vahid Rahimian and
Claudia A. Doege and
Fabienne Paumet and
William S. Eng and
Nancy Arango and
Francesco Parlati and
Mariella Ravazzola and
Lelio Orci and
Thomas H. Söllner and
James E. Rothman i-SNAREs . . . . . . . . . . . . . . . . 79
Clare L. Scott and
Martin Schuler and
Vanessa S. Marsden and
Alex Egle and
Marc Pellegrini and
Dobrila Nesic and
Steve Gerondakis and
Stephen L. Nutt and
Douglas R. Green and
Andreas Strasser Apaf-1 and caspase-9 do not act as tumor
suppressors in myc-induced
lymphomagenesis or mouse embryo
fibroblast transformation . . . . . . . 89
Sigol\`ene M. Meilhac and
Milan Esner and
Michel Kerszberg and
Julie E. Moss and
Margaret E. Buckingham Oriented clonal cell growth in the
developing mouse myocardium underlies
cardiac morphogenesis . . . . . . . . . 97
Jenny Hsieh and
James B. Aimone and
Brian K. Kaspar and
Tomoko Kuwabara and
Kinichi Nakashima and
Fred H. Gage IGF-I instructs multipotent adult neural
progenitor cells to become
oligodendrocytes . . . . . . . . . . . . 111
Jiunn-Tay Lee and
Jan Xu and
Jin-Moo Lee and
Grace Ku and
Xianlin Han and
Ding-I Yang and
Shawei Chen and
Chung Y. Hsu Amyloid-$ \beta $ peptide induces
oligodendrocyte death by activating the
neutral sphingomyelinase--ceramide
pathway . . . . . . . . . . . . . . . . 123
Christelle Benaud and
Beno\^\it J. Gentil and
Nicole Assard and
Magalie Court and
Jerome Garin and
Christian Delphin and
Jacques Baudier AHNAK interaction with the annexin
2/S100A10 complex regulates cell
membrane cytoarchitecture . . . . . . . 133
Alessandra Cambi and
Frank de Lange and
Noortje M. van Maarseveen and
Monique Nijhuis and
Ben Joosten and
Erik M. H. P. van Dijk and
Bärbel I. de Bakker and
Jack A. M. Fransen and
Petra H. M. Bovee-Geurts and
Frank N. van Leeuwen and
Niek F. Van Hulst and
Carl G. Figdor Microdomains of the C-type lectin
DC--SIGN are portals for virus entry
into dendritic cells . . . . . . . . . . 145
Alan W. Dove More than one way to skin a phagosome ??
Alan W. Dove How to terminate a shmoo . . . . . . . . ??
Alan W. Dove SNAREs drum up calcium . . . . . . . . . ??
Alan W. Dove Conjunction of junctions goes beyond
function . . . . . . . . . . . . . . . . ??
Alan W. Dove How insulin signals globally and acts
locally . . . . . . . . . . . . . . . . ??
Patricia Zambryski Cell-to-cell transport of proteins and
fluorescent tracers via plasmodesmata
during plant development . . . . . . . . 165
Hidekazu Iioka and
Naoto Ueno and
Noriyuki Kinoshita Essential role of MARCKS in cortical
actin dynamics during gastrulation
movements . . . . . . . . . . . . . . . 169
Walbert J. Bakker and
Montserrat Blázquez-Domingo and
Andrea Kolbus and
Janey Besooyen and
Peter Steinlein and
Hartmut Beug and
Paul J. Coffer and
Bob Löwenberg and
Marieke von Lindern and
Thamar B. van Dijk FoxO3a regulates erythroid
differentiation and induces BTG1, an
activator of protein arginine methyl
transferase 1 . . . . . . . . . . . . . 175
Rebecca M. Henry and
Adam D. Hoppe and
Nikhil Joshi and
Joel A. Swanson The uniformity of phagosome maturation
in macrophages . . . . . . . . . . . . . 185
Alexey J. Merz and
William T. Wickner Trans-SNARE interactions elicit
Ca$^{2+}$ efflux from the yeast vacuole
lumen . . . . . . . . . . . . . . . . . 195
Scott Bidlingmaier and
Michael Snyder Regulation of polarized growth
initiation and termination cycles by the
polarisome and Cdc42 regulators . . . . 207
Thomas Höfken and
Elmar Schiebel Novel regulation of mitotic exit by the
Cdc42 effectors Gic1 and Gic2 . . . . . 219
Catherine Lindon and
Jonathon Pines Ordered proteolysis in anaphase
inactivates Plk1 to contribute to proper
mitotic exit in human cells . . . . . . 233
Lorenza Ciani and
Olga Krylova and
Matthew J. Smalley and
Trevor C. Dale and
Patricia C. Salinas A divergent canonical WNT-signaling
pathway regulates microtubule dynamics 243
Hongmin Qin and
Dennis R. Diener and
Stefan Geimer and
Douglas G. Cole and
Joel L. Rosenbaum Intraflagellar transport (IFT) cargo . . 255
Anasua B. Kusari and
Douglas M. Molina and
Walid Sabbagh and
Chang S. Lau and
Lee Bardwell A conserved protein interaction network
involving the yeast MAP kinases Fus3 and
Kss1 . . . . . . . . . . . . . . . . . . 267
Makoto Kanzaki and
Silvia Mora and
Joseph B. Hwang and
Alan R. Saltiel and
Jeffrey E. Pessin Atypical protein kinase C (PKC$ \zeta $
/$ \lambda $) is a convergent downstream
target of the insulin-stimulated
phosphatidylinositol $3$-kinase and TC10
signaling pathways . . . . . . . . . . . 279
Weibin Shi and
Chuanxi Sun and
Bin He and
Wencheng Xiong and
Xingming Shi and
Dachun Yao and
Xu Cao GADD34--PP1c recruited by Smad7
dephosphorylates TGF$ \beta $ type I
receptor . . . . . . . . . . . . . . . . 291
Etsuko Takao-Rikitsu and
Sumiko Mochida and
Eiji Inoue and
Maki Deguchi-Tawarada and
Marie Inoue and
Toshihisa Ohtsuka and
Yoshimi Takai Physical and functional interaction of
the active zone proteins, CAST, RIM1,
and Bassoon, in neurotransmitter release 301
Victoria M. Wu and
Joost Schulte and
Alexander Hirschi and
Ulrich Tepass and
Greg J. Beitel Sinuous is a \bionameDrosophila claudin
required for septate junction
organization and epithelial tube size
control . . . . . . . . . . . . . . . . 313
Alan W. Dove New structure found in plain sight . . . ??
Alan W. Dove Krox-20 conducts the Schwann song . . . ??
Alan W. Dove Kinase cascades are binary to the bone ??
Alan W. Dove Switching mating types with one arm tied ??
Alan W. Dove Actin organizer takes pathogens for a
ride . . . . . . . . . . . . . . . . . . ??
Rabiya Tuma A sensitive measure of repression . . . ??
Rabiya Tuma Repopulating glioma cell lines . . . . . ??
Rabiya Tuma Sticking to PIP$_2$ . . . . . . . . . . ??
Rabiya Tuma Parsing p53 activity . . . . . . . . . . ??
Rabiya Tuma RNAi-mediated DNA silencing . . . . . . ??
William A. Wells Man the nanoscopes . . . . . . . . . . . 337
Benjamin P. Tu and
Jonathan S. Weissman Oxidative protein folding in eukaryotes 341
Michael Glotzer Cleavage furrow positioning . . . . . . 347
Nick I. Markevich and
Jan B. Hoek and
Boris N. Kholodenko Signaling switches and bistability
arising from multisite phosphorylation
in protein kinase cascades . . . . . . . 353
Debra A. Bressan and
Julio Vazquez and
James E. Haber Mating type-dependent constraints on the
mobility of the left arm of yeast
chromosome III . . . . . . . . . . . . . 361
Yoshikazu Imanishi and
Matthew L. Batten and
David W. Piston and
Wolfgang Baehr and
Krzysztof Palczewski Noninvasive two-photon imaging reveals
retinyl ester storage structures in the
eye . . . . . . . . . . . . . . . . . . 373
David B. Parkinson and
Ambily Bhaskaran and
Anna Droggiti and
Sarah Dickinson and
Maurizio D'Antonio and
Rhona Mirsky and
Kristjan R. Jessen Krox-20 inhibits Jun--NH$_2$-terminal
kinase/c--Jun to control Schwann cell
proliferation and death . . . . . . . . 385
Hiroshi Akazawa and
Sumiyo Kudoh and
Naoki Mochizuki and
Noboru Takekoshi and
Hiroyuki Takano and
Toshio Nagai and
Issei Komuro A novel LIM protein Cal promotes cardiac
differentiation by association with
CSX/NKX2-5 . . . . . . . . . . . . . . . 395
Kenneth G. Campellone and
Susannah Rankin and
Tony Pawson and
Marc W. Kirschner and
Donald J. Tipper and
John M. Leong Clustering of Nck by a $ 12$-residue Tir
phosphopeptide is sufficient to trigger
localized actin assembly . . . . . . . . 407
Andrew C. Zelhof and
Robert W. Hardy WASp is required for the correct
temporal morphogenesis of rhabdomere
microvilli . . . . . . . . . . . . . . . 417
Go Totsukawa and
Yue Wu and
Yasuharu Sasaki and
David J. Hartshorne and
Yoshihiko Yamakita and
Shigeko Yamashiro and
Fumio Matsumura Distinct roles of MLCK and ROCK in the
regulation of membrane protrusions and
focal adhesion dynamics during cell
migration of fibroblasts . . . . . . . . 427
Roberta Palumbo and
Maurilio Sampaolesi and
Francesco De Marchis and
Rossana Tonlorenzi and
Sara Colombetti and
Anna Mondino and
Giulio Cossu and
Marco E. Bianchi Extracellular HMGB1, a signal of tissue
damage, induces mesoangioblast migration
and proliferation . . . . . . . . . . . 441
Lijun Xia and
Tongzhong Ju and
Andrew Westmuckett and
Guangyu An and
Lacramioara Ivanciu and
J. Michael McDaniel and
Florea Lupu and
Richard D. Cummings and
Rodger P. McEver Defective angiogenesis and fatal
embryonic hemorrhage in mice lacking
core $1$--derived O-glycans . . . . . . 451
Trever G. Bivona and
Heidi H. Wiener and
Ian M. Ahearn and
Joseph Silletti and
Vi K. Chiu and
Mark R. Philips Rap1 up-regulation and activation on
plasma membrane regulates T cell
adhesion . . . . . . . . . . . . . . . . 461
Alan W. Dove How meals become bones . . . . . . . . . ??
Alan W. Dove A primordial mover for sphingolipids . . ??
Alan W. Dove Yeast dies for a noble cause . . . . . . ??
Alan W. Dove Boning up on JunB . . . . . . . . . . . ??
Alan W. Dove Apoptotic mitochondria blow a fuse . . . ??
Nicole LeBrasseur Protein splicing for immunity . . . . . ??
Nicole LeBrasseur Breathe, then breed . . . . . . . . . . ??
Nicole LeBrasseur Inflexibility in motion . . . . . . . . ??
Nicole LeBrasseur Winding and unwinding ATP synthase . . . ??
Nicole LeBrasseur Nanofibers have the right stuff . . . . ??
William A. Wells and
Nicole LeBrasseur Cells on Parade . . . . . . . . . . . . 480
Jiangtao Yu and
Shawna L. Fleming and
Byron Williams and
Erika V. Williams and
ZeXiao Li and
Patrizia Somma and
Conly L. Rieder and
Michael L. Goldberg Greatwall kinase . . . . . . . . . . . . 487
Mariusz Karbowski and
Damien Arnoult and
Hsiuchen Chen and
David C. Chan and
Carolyn L. Smith and
Richard J. Youle Quantitation of mitochondrial dynamics
by photolabeling of individual
organelles shows that mitochondrial
fusion is blocked during the Bax
activation phase of apoptosis . . . . . 493
Eva Herker and
Helmut Jungwirth and
Katharina A. Lehmann and
Corinna Maldener and
Kai-Uwe Fröhlich and
Silke Wissing and
Sabrina Büttner and
Markus Fehr and
Stephan Sigrist and
Frank Madeo Chronological aging leads to apoptosis
in yeast . . . . . . . . . . . . . . . . 501
Romain Dacquin and
Rachel A. Davey and
Catherine Laplace and
Régis Levasseur and
Howard A. Morris and
Steven R. Goldring and
Samuel Gebre-Medhin and
Deborah L. Galson and
Jeffrey D. Zajac and
Gérard Karsenty Amylin inhibits bone resorption while
the calcitonin receptor controls bone
formation in vivo . . . . . . . . . . . 509
Jayson Wang and
Carol Shiels and
Peter Sasieni and
Pei Jun Wu and
Suhail A. Islam and
Paul S. Freemont and
Denise Sheer Promyelocytic leukemia nuclear bodies
associate with transcriptionally active
genomic regions . . . . . . . . . . . . 515
Jonathan H. Zippin and
Jeanne Farrell and
David Huron and
Margarita Kamenetsky and
Kenneth C. Hess and
Donald A. Fischman and
Lonny R. Levin and
Jochen Buck Bicarbonate-responsive ``soluble''
adenylyl cyclase defines a nuclear cAMP
microdomain . . . . . . . . . . . . . . 527
Emily S. Gillett and
Christopher W. Espelin and
Peter K. Sorger Spindle checkpoint proteins and
chromosome--microtubule attachment in
budding yeast . . . . . . . . . . . . . 535
Krishnamurthy Malathi and
Katsumi Higaki and
Arthur H. Tinkelenberg and
Dina A. Balderes and
Dorca Almanzar-Paramio and
Lisa J. Wilcox and
Naz Erdeniz and
Francis Redican and
Mahajabeen Padamsee and
Ying Liu and
Sohail Khan and
Frederick Alcantara and
Eugene D. Carstea and
Jill A. Morris and
Stephen L. Sturley Mutagenesis of the putative
sterol-sensing domain of yeast Niemann
Pick C--related protein reveals a
primordial role in subcellular
sphingolipid distribution . . . . . . . 547
Yun Liang and
Wei Yu and
Yan Li and
Zhenye Yang and
Xiumin Yan and
Qiongping Huang and
Xueliang Zhu Nudel functions in membrane traffic
mainly through association with Lis1 and
cytoplasmic dynein . . . . . . . . . . . 557
Kyoungtae Kim and
Atsuko Yamashita and
Martin A. Wear and
Yuichiro Maéda and
John A. Cooper Capping protein binding to actin in
yeast . . . . . . . . . . . . . . . . . 567
Raymond Wightman and
Steven Bates and
Pat Amornrrattanapan and
Peter Sudbery In Candida albicans, the Nim1 kinases
Gin4 and Hsl1 negatively regulate
pseudohypha formation and Gin4 also
controls septin organization . . . . . . 581
Cai Huang and
Christoph H. Borchers and
Michael D. Schaller and
Ken Jacobson Phosphorylation of paxillin by p38MAPK
is involved in the neurite extension of
PC-12 cells . . . . . . . . . . . . . . 593
Hong Liu and
Derek C. Radisky and
Fei Wang and
Mina J. Bissell Polarity and proliferation are
controlled by distinct signaling
pathways downstream of PI3-kinase in
breast epithelial tumor cells . . . . . 603
Lukas Kenner and
Astrid Hoebertz and
F. Timo Beil and
Niamh Keon and
Florian Karreth and
Robert Eferl and
Harald Scheuch and
Agnieszka Szremska and
Michael Amling and
Marina Schorpp-Kistner and
Peter Angel and
Erwin F. Wagner Mice lacking JunB are osteopenic due to
cell-autonomous osteoblast and
osteoclast defects . . . . . . . . . . . 613
Michael Klemba and
Wandy Beatty and
Ilya Gluzman and
Daniel E. Goldberg Correction . . . . . . . . . . . . . . . 625
Nicole LeBrasseur Migration on rafts . . . . . . . . . . . ??
Nicole LeBrasseur Lumens laid out by PAR-1 . . . . . . . . ??
Nicole LeBrasseur The nucleus shuns MAPK . . . . . . . . . ??
Nicole LeBrasseur Muscle loves company . . . . . . . . . . ??
Nicole LeBrasseur Antigens make a pit stop . . . . . . . . ??
William A. Wells Backward waves move cells forward . . . ??
William A. Wells Flipping the fusion switch . . . . . . . ??
William A. Wells Solo polarization . . . . . . . . . . . ??
William A. Wells Pulling out gene silencers . . . . . . . ??
William A. Wells Die --- but not just yet . . . . . . . . ??
Thoru Pederson Can telomerase be put in its place? . . 637
Vladimir I. Titorenko and
Richard A. Rachubinski The peroxisome . . . . . . . . . . . . . 641
Beáta E. Jády and
Edouard Bertrand and
Tamás Kiss Human telomerase RNA and box H/ACA
scaRNAs share a common Cajal
body--specific localization signal . . . 647
Bruno T. Fievet and
Alexis Gautreau and
Christian Roy and
Laurence Del Maestro and
Paul Mangeat and
Daniel Louvard and
Monique Arpin Phosphoinositide binding and
phosphorylation act sequentially in the
activation mechanism of ezrin . . . . . 653
Sabine H. Wimmer-Kleikamp and
Peter W. Janes and
Anthony Squire and
Philippe I. H. Bastiaens and
Martin Lackmann Recruitment of Eph receptors into
signaling clusters does not require
ephrin contact . . . . . . . . . . . . . 661
Hugues Lelouard and
Vincent Ferrand and
Didier Marguet and
Jacek Bania and
Voahirana Camosseto and
Alexandre David and
Evelina Gatti and
Philippe Pierre Dendritic cell aggresome-like induced
structures are dedicated areas for
ubiquitination and storage of newly
synthesized defective proteins . . . . . 667
Matthew J. Youngman and
Alyson E. Aiken Hobbs and
Shawn M. Burgess and
Maithreyan Srinivasan and
Robert E. Jensen Mmm2p, a mitochondrial outer membrane
protein required for yeast mitochondrial
shape and maintenance of mtDNA nucleoids 677
Elizabeth R. Smith and
Jennifer L. Smedberg and
Malgorzata E. Rula and
Xiang-Xi Xu Regulation of Ras--MAPK pathway
mitogenic activity by restricting
nuclear entry of activated MAPK in
endoderm differentiation of embryonic
carcinoma and stem cells . . . . . . . . 689
Matthias Versele and
Jeremy Thorner Septin collar formation in budding yeast
requires GTP binding and direct
phosphorylation by the PAK, Cla4 . . . . 701
David Cohen and
Patrick J. Brennwald and
Enrique Rodriguez-Boulan and
Anne Müsch Mammalian PAR-1 determines epithelial
lumen polarity by organizing the
microtubule cytoskeleton . . . . . . . . 717
Yasushi Izumi and
Nao Ohta and
Asako Itoh-Furuya and
Naoyuki Fuse and
Fumio Matsuzaki Differential functions of G protein and
Baz--aPKC signaling pathways in
\bionameDrosophila neuroblast asymmetric
division . . . . . . . . . . . . . . . . 729
Jacquelyn Gerhart and
Christine Neely and
Benjamin Stewart and
Jordanna Perlman and
David Beckmann and
Margaretha Wallon and
Karen Knudsen and
Mindy George-Weinstein Epiblast cells that express MyoD recruit
pluripotent cells to the skeletal muscle
lineage . . . . . . . . . . . . . . . . 739
Patrick Smits and
Peter Dy and
Srijeet Mitra and
Véronique Lefebvre Sox5 and Sox6 are needed to develop and
maintain source, columnar, and
hypertrophic chondrocytes in the
cartilage growth plate . . . . . . . . . 747
Concepción Gómez-Moutón and
Rosa Ana Lacalle and
Emilia Mira and
Sonia Jiménez-Baranda and
Domingo F. Barber and
Ana C. Carrera and
Carlos Martínez-A. and
Santos Mañes Dynamic redistribution of raft domains
as an organizing platform for signaling
during cell chemotaxis . . . . . . . . . 759
Umut Sahin and
Gisela Weskamp and
Kristine Kelly and
Hong-Ming Zhou and
Shigeki Higashiyama and
Jacques Peschon and
Dieter Hartmann and
Paul Saftig and
Carl P. Blobel Distinct roles for ADAM10 and ADAM17 in
ectodomain shedding of six EGFR ligands 769
Karen Birmingham Cilia that sense . . . . . . . . . . . . ??
Karen Birmingham Bigger equals faster . . . . . . . . . . ??
Karen Birmingham Keratins make you regular . . . . . . . ??
Karen Birmingham Stay dynamic to slow aging . . . . . . . ??
Karen Birmingham Binding to the basement . . . . . . . . ??
Nicole LeBrasseur Endosomes are ready and APPL to signal ??
Nicole LeBrasseur Feudal system in metabolic flux . . . . ??
Nicole LeBrasseur Any which way but loose . . . . . . . . ??
Nicole LeBrasseur A dynamite intercellular highway . . . . ??
Nicole LeBrasseur Teeny tiny rafts . . . . . . . . . . . . ??
Nicole R. Murray and
Lee Jamieson and
Wangsheng Yu and
Jie Zhang and
Yesim Gökmen-Polar and
Deborah Sier and
Panos Anastasiadis and
Zoran Gatalica and
E. Aubrey Thompson and
Alan P. Fields Protein kinase C$ \iota $ is required
for Ras transformation and colon
carcinogenesis in vivo . . . . . . . . . 797
Campbell W. Gourlay and
Lindsay N. Carpp and
Paul Timpson and
Steven J. Winder and
Kathryn R. Ayscough A role for the actin cytoskeleton in
cell death and aging in yeast . . . . . 803
Carlo Iomini and
Karla Tejada and
Wenjun Mo and
Heikki Vaananen and
Gianni Piperno Primary cilia of human endothelial cells
disassemble under laminar shear stress 811
Hayley A. Webber and
Louisa Howard and
Sharon E. Bickel The cohesion protein ORD is required for
homologue bias during meiotic
recombination . . . . . . . . . . . . . 819
Miroslav Dundr and
Michael D. Hebert and
Tatiana S. Karpova and
David Stanek and
Hongzi Xu and
Karl B. Shpargel and
U. Thomas Meier and
Karla M. Neugebauer and
A. Gregory Matera and
Tom Misteli In vivo kinetics of Cajal body
components . . . . . . . . . . . . . . . 831
Stefan Wagner and
Simion Chiosea and
Maria Ivshina and
Jeffrey A. Nickerson In vitro FRAP reveals the ATP-dependent
nuclear mobilization of the exon
junction complex protein SRm160 . . . . 843
James I. S. MacDonald and
Chris J. Kubu and
Susan O. Meakin Nesca, a novel adapter, translocates to
the nuclear envelope and regulates
neurotrophin-induced neurite outgrowth 851
Yi Fang and
James C. Morrell and
Jacob M. Jones and
Stephen J. Gould PEX3 functions as a PEX19 docking factor
in the import of class I peroxisomal
membrane proteins . . . . . . . . . . . 863
Dimitry N. Krementsov and
Elena B. Krementsova and
Kathleen M. Trybus Myosin V . . . . . . . . . . . . . . . . 877
Agnieszka K. Rzadzinska and
Mark E. Schneider and
Caroline Davies and
Gavin P. Riordan and
Bechara Kachar An actin molecular treadmill and myosins
maintain stereocilia functional
architecture and self-renewal . . . . . 887
Falak M. Helwani and
Eva M. Kovacs and
Andrew D. Paterson and
Suzie Verma and
Radiya G. Ali and
Alan S. Fanning and
Scott A. Weed and
Alpha S. Yap Cortactin is necessary for
E-cadherin-mediated contact formation
and actin reorganization . . . . . . . . 899
Diana M. Toivola and
Selvi Krishnan and
Henry J. Binder and
Satish K. Singh and
M. Bishr Omary Keratins modulate colonocyte electrolyte
transport via protein mistargeting . . . 911
Manu Sharma and
Francesca Pampinella and
Csilla Nemes and
Mohamed Benharouga and
Jeffrey So and
Kai Du and
Kristi G. Bache and
Blake Papsin and
Noa Zerangue and
Harald Stenmark and
Gergely L. Lukacs Misfolding diverts CFTR from recycling
to degradation . . . . . . . . . . . . . 923
Hui Wang and
Weili Fu and
Jae Hong Im and
Zengyi Zhou and
Samuel A. Santoro and
Vandana Iyer and
C. Mike DiPersio and
Qian-Chun Yu and
Vito Quaranta and
Abu Al-Mehdi and
Ruth J. Muschel Tumor cell $ \alpha_3 \beta_1 $ integrin
and vascular laminin-5 mediate pulmonary
arrest and metastasis . . . . . . . . . 935
Hongmin Qin and
Dennis R. Diener and
Stefan Geimer and
Douglas G. Cole and
Joel L. Rosenbaum Correction . . . . . . . . . . . . . . . 943
Nicole LeBrasseur Nerveless muscles shape up . . . . . . . ??
Nicole LeBrasseur Kinases speak from the Golgi . . . . . . ??
Nicole LeBrasseur No more division . . . . . . . . . . . . ??
Nicole LeBrasseur Ubiquitin cycles for Golgi fusion . . . ??
Nicole LeBrasseur Two arms of TGF$ \beta $ signaling . . . ??
William A. Wells How transmembranes tell of their
approach . . . . . . . . . . . . . . . . ??
William A. Wells All in the (network) family . . . . . . ??
William A. Wells Snaring bugs in NETs . . . . . . . . . . ??
William A. Wells Surviving to remember . . . . . . . . . ??
William A. Wells Actin as stairmaster . . . . . . . . . . ??
Francis A. Barr Golgi inheritance . . . . . . . . . . . 955
Takako Sasaki and
Reinhard Fässler and
Erhard Hohenester Laminin . . . . . . . . . . . . . . . . 959
Sowmya Swaminathan and
Florian Kiendl and
Roman Körner and
Raffaella Lupetti and
Ludger Hengst and
Frauke Melchior RanGAP1*SUMO1 is phosphorylated at the
onset of mitosis and remains associated
with RanBP2 upon NPC disassembly . . . . 965
Yanzhuang Wang and
Ayano Satoh and
Graham Warren and
Hemmo H. Meyer VCIP135 acts as a deubiquitinating
enzyme during p97--p47-mediated
reassembly of mitotic Golgi fragments 973
Masakiyo Sakaguchi and
Masahiro Miyazaki and
Hiroyuki Sonegawa and
Mariko Kashiwagi and
Motoi Ohba and
Toshio Kuroki and
Masayoshi Namba and
Nam-ho Huh PKC$ \alpha $ mediates TGF$ \beta
$-induced growth inhibition of human
keratinocytes via phosphorylation of
S100C/A11 . . . . . . . . . . . . . . . 979
Alexandra Chittka and
Juan Carlos Arevalo and
Maria Rodriguez-Guzman and
Pilar Pérez and
Moses V. Chao and
Michael Sendtner The p75NTR-interacting protein SC1
inhibits cell cycle progression by
transcriptional repression of cyclin E 985
Erik L. Snapp and
Gretchen A. Reinhart and
Brigitte A. Bogert and
Jennifer Lippincott-Schwartz and
Ramanujan S. Hegde The organization of engaged and
quiescent translocons in the endoplasmic
reticulum of mammalian cells . . . . . . 997
Christian Preisinger and
Benjamin Short and
Veerle De Corte and
Erik Bruyneel and
Alexander Haas and
Robert Kopajtich and
Jan Gettemans and
Francis A. Barr YSK1 is activated by the Golgi matrix
protein GM130 and plays a role in cell
migration through its substrate 14-3-3$
\zeta $ . . . . . . . . . . . . . . . . 1009
Anna Schinzel and
Thomas Kaufmann and
Martin Schuler and
Jorge Martinalbo and
David Grubb and
Christoph Borner Conformational control of Bax
localization and apoptotic activity by
Pro168 . . . . . . . . . . . . . . . . . 1021
Guillaume Halet and
Richard Tunwell and
Scott J. Parkinson and
John Carroll Conventional PKCs regulate the temporal
pattern of Ca$^{2+}$ oscillations at
fertilization in mouse eggs . . . . . . 1033
Enrico S. Montana and
J. Troy Littleton Characterization of a
hypercontraction-induced myopathy in
\bionameDrosophila caused by mutations
in Mhc . . . . . . . . . . . . . . . . . 1045
Henry C. Chang and
Michael Hull and
Ira Mellman The J-domain protein Rme-8 interacts
with Hsc70 to control clathrin-dependent
endocytosis in \bionameDrosophila . . . 1055
Andrew A. Peden and
Viola Oorschot and
Boris A. Hesser and
Cary D. Austin and
Richard H. Scheller and
Judith Klumperman Localization of the AP-3 adaptor complex
defines a novel endosomal exit site for
lysosomal membrane proteins . . . . . . 1065
Terrance T. Kummer and
Thomas Misgeld and
Jeff W. Lichtman and
Joshua R. Sanes Nerve-independent formation of a
topologically complex postsynaptic
apparatus . . . . . . . . . . . . . . . 1077
William A. Wells Checking folding inside and out . . . . ??
William A. Wells Don't digest the messenger . . . . . . . ??
William A. Wells Foci of decay . . . . . . . . . . . . . ??
William A. Wells Brain construction goes straight . . . . ??
William A. Wells Formin a shmoo . . . . . . . . . . . . . ??
Nicole LeBrasseur RNA de-inhibition . . . . . . . . . . . ??
Nicole LeBrasseur Cholesterol hastens Alzheimer's . . . . ??
Nicole LeBrasseur The two faces of Mad2 . . . . . . . . . ??
Nicole LeBrasseur Assembling yeast complexes . . . . . . . ??
Nicole LeBrasseur Mass dedifferentiation . . . . . . . . . ??
Ira Mellman Providing realistic access . . . . . . . 19
Karen R. Dell and
Ronald D. Vale A tribute to Shinya Inoue and innovation
in light microscopy . . . . . . . . . . 21
Laura Korhonen and
Dan Lindholm The ubiquitin proteasome system in
synaptic and axonal degeneration . . . . 27
Nicolas Cougot and
Sylvie Babajko and
Bertrand Séraphin Cytoplasmic foci are sites of mRNA decay
in human cells . . . . . . . . . . . . . 31
Shilpa Vashist and
Davis T. W. Ng Misfolded proteins are sorted by a
sequential checkpoint mechanism of ER
quality control . . . . . . . . . . . . 41
Shushi Nagamori and
Irina N. Smirnova and
H. Ronald Kaback Role of YidC in folding of polytopic
membrane proteins . . . . . . . . . . . 53
Lu Sun and
Khaled Machaca Ca$^{2+}_{cyt}$ negatively regulates the
initiation of oocyte maturation . . . . 63
Jingxia Li and
Haobin Chen and
Moon-Shong Tang and
Xianglin Shi and
Shantu Amin and
Dhimant Desai and
Max Costa and
Chuanshu Huang PI-3K and Akt are mediators of AP-1
induction by 5-MCDE in mouse epidermal
Cl41 cells . . . . . . . . . . . . . . . 77
Xiang Fang and
Hong Ji and
Si-Wan Kim and
Jae-Il Park and
Travis G. Vaught and
Panos Z. Anastasiadis and
Malgorzata Ciesiolka and
Pierre D. McCrea Vertebrate development requires ARVCF
and p120 catenins and their interplay
with RhoA and Rac . . . . . . . . . . . 87
Dina Matheos and
Metodi Metodiev and
Eric Muller and
David Stone and
Mark D. Rose Pheromone-induced polarization is
dependent on the Fus3p MAPK acting
through the formin Bni1p . . . . . . . . 99
Matthew N. J. Seaman Cargo-selective endosomal sorting for
retrieval to the Golgi requires retromer 111
Cecilia N. Arighi and
Lisa M. Hartnell and
Ruben C. Aguilar and
Carol R. Haft and
Juan S. Bonifacino Role of the mammalian retromer in
sorting of the cation-independent
mannose $6$-phosphate receptor . . . . . 123
Rebecca Dunn and
Deborah A. Klos and
Adam S. Adler and
Linda Hicke The C2 domain of the Rsp5 ubiquitin
ligase binds membrane phosphoinositides
and directs ubiquitination of endosomal
cargo . . . . . . . . . . . . . . . . . 135
Kyoko Itoh and
Ling Cheng and
Yoshimasa Kamei and
Shinji Fushiki and
Hiroyuki Kamiguchi and
Paul Gutwein and
Alexander Stoeck and
Bernd Arnold and
Peter Altevogt and
Vance Lemmon Brain development in mice lacking L1--L1
homophilic adhesion . . . . . . . . . . 145
Vladimir I. Titorenko and
Richard A. Rachubinski Correction . . . . . . . . . . . . . . . 155
Nicole LeBrasseur Lethargic mitochondria are left out . . ??
Nicole LeBrasseur Arpless comets are fascin-ating . . . . ??
Nicole LeBrasseur PKCs pick through Ca$^{2+}$ . . . . . . ??
Nicole LeBrasseur Next vesicle SNAP'd up . . . . . . . . . ??
Nicole LeBrasseur Tracking transcripts . . . . . . . . . . ??
William A. Wells Rafting across polarized cells . . . . . ??
William A. Wells Myc conquers all . . . . . . . . . . . . ??
William A. Wells Telomeres together . . . . . . . . . . . ??
William A. Wells Being intolerant of tumors . . . . . . . ??
William A. Wells Get out! And don't come back! . . . . . ??
Mark Herlan and
Carsten Bornhövd and
Kai Hell and
Walter Neupert and
Andreas S. Reichert Alternative topogenesis of Mgm1 and
mitochondrial morphology depend on ATP
and a functional import motor . . . . . 167
Katja Köhler and
Daniel Louvard and
Ahmed Zahraoui Rab13 regulates PKA signaling during
tight junction assembly . . . . . . . . 175
Maren Oehlmann and
Alan J. Score and
J. Julian Blow The role of Cdc6 in ensuring complete
genome licensing and S phase checkpoint
activation . . . . . . . . . . . . . . . 181
Chris Molenaar and
Abadir Abdulle and
Aarti Gena and
Hans J. Tanke and
Roeland W. Dirks Poly(A) $^+$ RNAs roam the cell nucleus
and pass through speckle domains in
transcriptionally active and inactive
cells . . . . . . . . . . . . . . . . . 191
Tracy L. Kress and
Young J. Yoon and
Kimberly L. Mowry Nuclear RNP complex assembly initiates
cytoplasmic RNA localization . . . . . . 203
Martin van der Laan and
Philipp Bechtluft and
Stef Kol and
Nico Nouwen and
Arnold J. M. Driessen F$_1$ F$_0$ ATP synthase subunit c is a
substrate of the novel YidC pathway for
membrane protein biogenesis . . . . . . 213
Paolo Pinton and
Sara Leo and
Mariusz R. Wieckowski and
Giulietta Di Benedetto and
Rosario Rizzuto Long-term modulation of mitochondrial
Ca$^{2+}$ signals by protein kinase C
isozymes . . . . . . . . . . . . . . . . 223
William M. Brieher and
Margaret Coughlin and
Timothy J. Mitchison Fascin-mediated propulsion of
\bionameListeria monocytogenes
independent of frequent nucleation by
the Arp2/3 complex . . . . . . . . . . . 233
Satoshi Komatsu and
Mitsuo Ikebe ZIP kinase is responsible for the
phosphorylation of myosin II and
necessary for cell motility in mammalian
fibroblasts . . . . . . . . . . . . . . 243
Noriko Takahashi and
Hiroyasu Hatakeyama and
Haruo Okado and
Akiko Miwa and
Takuya Kishimoto and
Tatsuya Kojima and
Teruo Abe and
Haruo Kasai Sequential exocytosis of insulin
granules is associated with
redistribution of SNAP25 . . . . . . . . 255
Carolyn N. Wrobel and
Jayanta Debnath and
Eva Lin and
Sean Beausoleil and
Martine F. Roussel and
Joan S. Brugge Autocrine CSF-1R activation promotes
Src-dependent disruption of mammary
epithelial architecture . . . . . . . . 263
Yuji Yamaguchi and
Satoshi Itami and
Hidenori Watabe and
Ken-ichi Yasumoto and
Zalfa A. Abdel-Malek and
Tateki Kubo and
François Rouzaud and
Atsushi Tanemura and
Kunihiko Yoshikawa and
Vincent J. Hearing Mesenchymal-epithelial interactions in
the skin . . . . . . . . . . . . . . . . 275
William A. Wells An anchor for motoring . . . . . . . . . ??
William A. Wells Arg links actin and microtubules . . . . ??
William A. Wells A caspase for stress . . . . . . . . . . ??
William A. Wells Monomeric myosin anchoring . . . . . . . ??
William A. Wells Sensing detachment . . . . . . . . . . . ??
Nicole LeBrasseur Intimacy is a cellular turn-on . . . . . ??
Nicole LeBrasseur Fighting foreigners prevents
self-destruction . . . . . . . . . . . . ??
Nicole LeBrasseur A Rho for the kinetochore . . . . . . . ??
Nicole LeBrasseur Death comes in small packages . . . . . ??
Nicole LeBrasseur Fat and bone . . . . . . . . . . . . . . ??
Kendall Powell All systems go . . . . . . . . . . . . . 299
Maddalena de Virgilio and
William B. Kiosses and
Sanford J. Shattil Proximal, selective, and dynamic
interactions between integrin $ \alpha
$IIb$ \beta $3 and protein tyrosine
kinases in living cells . . . . . . . . 305
Cynthia Y. He and
Helen H. Ho and
Joerg Malsam and
Cecile Chalouni and
Christopher M. West and
Elisabetta Ullu and
Derek Toomre and
Graham Warren Golgi duplication in Trypanosoma brucei 313
Matthew D. Smith and
Caleb M. Rounds and
Fei Wang and
Kunhua Chen and
Meshack Afitlhile and
Danny J. Schnell atToc159 is a selective transit peptide
receptor for the import of
nucleus-encoded chloroplast proteins . . 323
Christina A. Wilson and
Diane D. Murphy and
Benoit I. Giasson and
Bin Zhang and
John Q. Trojanowski and
Virginia M.-Y. Lee Degradative organelles containing
mislocalized $ \alpha $- and $ \beta
$-synuclein proliferate in presenilin-1
null neurons . . . . . . . . . . . . . . 335
Junichi Hitomi and
Taiichi Katayama and
Yutaka Eguchi and
Takashi Kudo and
Manabu Taniguchi and
Yoshihisa Koyama and
Takayuki Manabe and
Satoru Yamagishi and
Yoshio Bando and
Kazunori Imaizumi and
Yoshihide Tsujimoto and
Masaya Tohyama Involvement of caspase-4 in endoplasmic
reticulum stress-induced apoptosis and
A$ \beta $-induced cell death . . . . . 347
Srinivasa Subramaniam and
Ute Zirrgiebel and
Oliver von Bohlen und Halbach and
Jens Strelau and
Christine Laliberté and
David R. Kaplan and
Klaus Unsicker ERK activation promotes neuronal
degeneration predominantly through
plasma membrane damage and independently
of caspase-3 . . . . . . . . . . . . . . 357
M. Cecilia Subauste and
Olivier Pertz and
Eileen D. Adamson and
Christopher E. Turner and
Sachiko Junger and
Klaus M. Hahn Vinculin modulation of paxillin--FAK
interactions regulates ERK to control
survival and motility . . . . . . . . . 371
Elizabeth Gaskins and
Stacey Gilk and
Nicolette DeVore and
Tara Mann and
Gary Ward and
Con Beckers Identification of the membrane receptor
of a class XIV myosin in Toxoplasma
gondii . . . . . . . . . . . . . . . . . 383
Matthew J. Tyska and
Mark S. Mooseker A role for myosin-1A in the localization
of a brush border disaccharidase . . . . 395
Ann L. Miller and
Yinxiang Wang and
Mark S. Mooseker and
Anthony J. Koleske The Abl-related gene (Arg) requires its
F-actin--microtubule cross-linking
activity to regulate lamellipodial
dynamics during fibroblast adhesion . . 407
Yi Hsing Lin and
Zee-Yong Park and
Dayin Lin and
Anar A. Brahmbhatt and
Marie-Christine Rio and
John R. Yates and
Richard L. Klemke Regulation of cell migration and
survival by focal adhesion targeting of
Lasp-1 . . . . . . . . . . . . . . . . . 421
Mitsuru Horiki and
Takeshi Imamura and
Mina Okamoto and
Makoto Hayashi and
Junko Murai and
Akira Myoui and
Takahiro Ochi and
Kohei Miyazono and
Hideki Yoshikawa and
Noriyuki Tsumaki Smad6\slash Smurf1 overexpression in
cartilage delays chondrocyte hypertrophy
and causes dwarfism with osteopenia . . 433
Nicole LeBrasseur Fingers lay fibers . . . . . . . . . . . ??
Nicole LeBrasseur Sticky sugar . . . . . . . . . . . . . . ??
Nicole LeBrasseur Geminin halts DNA synthesis . . . . . . ??
Nicole LeBrasseur Slingshot to the lamellipod . . . . . . ??
Nicole LeBrasseur NG2$^+$ cells feed the brain . . . . . . ??
William A. Wells Tilt back to turn left . . . . . . . . . ??
William A. Wells Pulling the spindle into shape . . . . . ??
William A. Wells How to become a generalist again . . . . ??
William A. Wells Metabolism as a production line . . . . ??
William A. Wells Making waves . . . . . . . . . . . . . . ??
Irene M. Ward and
Bernardo Reina-San-Martin and
Alexandru Olaru and
Kay Minn and
Koji Tamada and
Julie S. Lau and
Marilia Cascalho and
Lieping Chen and
Andre Nussenzweig and
Ferenc Livak and
Michel C. Nussenzweig and
Junjie Chen 53BP1 is required for class switch
recombination . . . . . . . . . . . . . 459
Kyoko Nagata-Ohashi and
Yusaku Ohta and
Kazumichi Goto and
Shuhei Chiba and
Reiko Mori and
Michiru Nishita and
Kazumasa Ohashi and
Kazuyoshi Kousaka and
Akihiro Iwamatsu and
Ryusuke Niwa and
Tadashi Uemura and
Kensaku Mizuno A pathway of neuregulin-induced
activation of cofilin-phosphatase
Slingshot and cofilin in lamellipodia 465
Marina Melixetian and
Andrea Ballabeni and
Laura Masiero and
Patrizia Gasparini and
Raffaella Zamponi and
Jiri Bartek and
Jiri Lukas and
Kristian Helin Loss of Geminin induces rereplication in
the presence of functional p53 . . . . . 473
Kris M. Mann and
Jenna Lynn Ray and
Edward S. Moon and
Kristin M. Sass and
Mark R. Benson Calcineurin initiates smooth muscle
differentiation in neural crest stem
cells . . . . . . . . . . . . . . . . . 483
Pamela J. Woodring and
Jill Meisenhelder and
Sam A. Johnson and
Guo-Lei Zhou and
Jeffrey Field and
Kavita Shah and
Friedhelm Bladt and
Tony Pawson and
Masaru Niki and
Pier Paolo Pandolfi and
Jean Y. J. Wang and
Tony Hunter c-Abl phosphorylates Dok1 to promote
filopodia during cell spreading . . . . 493
Annie Cartaud and
Laure Strochlic and
Manuel Guerra and
Beno\^\it Blanchard and
Monique Lambergeon and
Eric Krejci and
Jean Cartaud and
Claire Legay MuSK is required for anchoring
acetylcholinesterase at the
neuromuscular junction . . . . . . . . . 505
Takuji Tanoue and
Masatoshi Takeichi Mammalian Fat1 cadherin regulates actin
dynamics and cell--cell contact . . . . 517
Iwona Bucior and
Simon Scheuring and
Andreas Engel and
Max M. Burger Carbohydrate--carbohydrate interaction
provides adhesion force and specificity
for cellular recognition . . . . . . . . 529
Satoshi Yamaji and
Atsushi Suzuki and
Heiwa Kanamori and
Wataru Mishima and
Ryusuke Yoshimi and
Hirotaka Takasaki and
Maki Takabayashi and
Katsumichi Fujimaki and
Shin Fujisawa and
Shigeo Ohno and
Yoshiaki Ishigatsubo Affixin interacts with $ \alpha
$-actinin and mediates integrin
signaling for reorganization of F-actin
induced by initial cell--substrate
interaction . . . . . . . . . . . . . . 539
Elizabeth G. Canty and
Yinhui Lu and
Roger S. Meadows and
Michael K. Shaw and
David F. Holmes and
Karl E. Kadler Coalignment of plasma membrane channels
and protrusions (fibripositors)
specifies the parallelism of tendon . . 553
Annette E. Rünker and
Igor Kobsar and
Torsten Fink and
Gabriele Loers and
Thomas Tilling and
Peggy Putthoff and
Carsten Wessig and
Rudolf Martini and
Melitta Schachner Pathology of a mouse mutation in
peripheral myelin protein P0 is
characteristic of a severe and early
onset form of human
Charcot--Marie--Tooth type 1B disorder 565
Adan A. Aguirre and
Ramesh Chittajallu and
Shibeshih Belachew and
Vittorio Gallo NG2-expressing cells in the
subventricular zone are type C-like
cells and contribute to interneuron
generation in the postnatal hippocampus 575
Andreas Wodarz and
Andreas Ramrath and
Alexandra Grimm and
Elisabeth Knust Correction . . . . . . . . . . . . . . . 591
Srinivasa Subramaniam and
Ute Zirrgiebel and
Oliver von Bohlen und Halbach and
Jens Strelau and
Christine Laliberté and
David R. Kaplan and
Klaus Unsicker Correction . . . . . . . . . . . . . . . 593
Aparna Sreenivasan Pulling on a cytokine . . . . . . . . . ??
Aparna Sreenivasan Mineralized mice . . . . . . . . . . . . ??
Aparna Sreenivasan An exit exchanger . . . . . . . . . . . ??
Aparna Sreenivasan Fast rafting . . . . . . . . . . . . . . ??
Aparna Sreenivasan Building centrioles . . . . . . . . . . ??
Nicole LeBrasseur The pore--transcription connection . . . ??
Nicole LeBrasseur Immune to autoimmunity . . . . . . . . . ??
Nicole LeBrasseur Uncertainty in structures . . . . . . . ??
Nicole LeBrasseur Pollen spares all but self . . . . . . . ??
Nicole LeBrasseur Cells step back in time . . . . . . . . ??
P. Todd Stukenberg Triggering p53 after cytokinesis failure 607
Yumi Uetake and
Greenfield Sluder Cell cycle progression after cleavage
failure . . . . . . . . . . . . . . . . 609
Yoichi Miyamoto and
Takuya Saiwaki and
Junichi Yamashita and
Yoshinari Yasuda and
Ippei Kotera and
Satoshi Shibata and
Masaki Shigeta and
Yasushi Hiraoka and
Tokuko Haraguchi and
Yoshihiro Yoneda Cellular stresses induce the nuclear
accumulation of importin $ \alpha $ and
cause a conventional nuclear import
block . . . . . . . . . . . . . . . . . 617
Monzur Murshed and
Thorsten Schinke and
Marc D. McKee and
Gerard Karsenty Extracellular matrix mineralization is
regulated locally; different roles of
two gla-containing proteins . . . . . . 625
Dimitrios Cakouros and
Tasman J. Daish and
Sharad Kumar Ecdysone receptor directly binds the
promoter of the \bionameDrosophila
caspase dronc, regulating its expression
in specific tissues . . . . . . . . . . 631
Kousuke Kasahara and
Yuji Nakayama and
Kikuko Ikeda and
Yuka Fukushima and
Daisuke Matsuda and
Shinya Horimoto and
Naoto Yamaguchi Trafficking of Lyn through the Golgi
caveolin involves the charged residues
on $ \alpha $E and $ \alpha $I helices
in the kinase domain . . . . . . . . . . 641
Gustavo Arrizabalaga and
Felix Ruiz and
Silvia Moreno and
John C. Boothroyd Ionophore-resistant mutant of Toxoplasma
gondii reveals involvement of a
sodium/hydrogen exchanger in calcium
regulation . . . . . . . . . . . . . . . 653
Kumi Matsuura and
Paul A. Lefebvre and
Ritsu Kamiya and
Masafumi Hirono Bld10p, a novel protein essential for
basal body assembly in Chlamydomonas . . 663
Maruxa Martinez-Campos and
Renata Basto and
James Baker and
Maurice Kernan and
Jordan W. Raff The \bionameDrosophila pericentrin-like
protein is essential for cilia/flagella
function, but appears to be dispensable
for mitosis . . . . . . . . . . . . . . 673
Fumio Motegi and
Mithilesh Mishra and
Mohan K. Balasubramanian and
Issei Mabuchi Myosin-II reorganization during mitosis
is controlled temporally by its
dephosphorylation and spatially by Mid1
in fission yeast . . . . . . . . . . . . 685
Becket Feierbach and
Fulvia Verde and
Fred Chang Regulation of a formin complex by the
microtubule plus end protein tea1p . . . 697
Teruyuki Tanaka and
Finley F. Serneo and
Christine Higgins and
Michael J. Gambello and
Anthony Wynshaw-Boris and
Joseph G. Gleeson Lis1 and doublecortin function with
dynein to mediate coupling of the
nucleus to the centrosome in neuronal
migration . . . . . . . . . . . . . . . 709
Justin P. Annes and
Yan Chen and
John S. Munger and
Daniel B. Rifkin Integrin $ \alpha_V \beta_6 $-mediated
activation of latent TGF-$ \beta $
requires the latent TGF-$ \beta $
binding protein-1 . . . . . . . . . . . 723
Anne K. Kenworthy and
Benjamin J. Nichols and
Catha L. Remmert and
Glenn M. Hendrix and
Mukesh Kumar and
Joshua Zimmerberg and
Jennifer Lippincott-Schwartz Dynamics of putative raft-associated
proteins at the cell surface . . . . . . 735
Aparna Sreenivasan Zombie cells . . . . . . . . . . . . . . ??
Aparna Sreenivasan Actin gets Hip at the TGN . . . . . . . ??
Aparna Sreenivasan Stuck in the divide . . . . . . . . . . ??
Aparna Sreenivasan Mixed guidance . . . . . . . . . . . . . ??
Aparna Sreenivasan Tumors make do with less matrix . . . . ??
William A. Wells Me write pretty one day . . . . . . . . 757
Creighton T. Tuzon and
Britta Borgstrom and
Dietmar Weilguny and
Richard Egel and
Julia Promisel Cooper and
Olaf Nielsen The fission yeast heterochromatin
protein Rik1 is required for telomere
clustering during meiosis . . . . . . . 759
Sara Salinas and
Anne Briançon-Marjollet and
Guillaume Bossis and
Marie-Aude Lopez and
Marc Piechaczyk and
Isabelle Jariel-Encontre and
Anne Debant and
Robert A. Hipskind SUMOylation regulates nucleo-cytoplasmic
shuttling of Elk-1 . . . . . . . . . . . 767
Vanessa S. Marsden and
Paul G. Ekert and
Mark Van Delft and
David L. Vaux and
Jerry M. Adams and
Andreas Strasser Bcl-2-regulated apoptosis and cytochrome
c release can occur independently of
both caspase-2 and caspase-9 . . . . . . 775
Sebastien Carreno and
Åsa E. Engqvist-Goldstein and
Claire X. Zhang and
Kent L. McDonald and
David G. Drubin Actin dynamics coupled to
clathrin-coated vesicle formation at the
trans-Golgi network . . . . . . . . . . 781
Susanna Ekholm-Reed and
Juan Méndez and
Donato Tedesco and
Anders Zetterberg and
Bruce Stillman and
Steven I. Reed Deregulation of cyclin E in human cells
interferes with prereplication complex
assembly . . . . . . . . . . . . . . . . 789
Wenhui Li and
Soo-Mi Kim and
Joon Lee and
William G. Dunphy Absence of BLM leads to accumulation of
chromosomal DNA breaks during both
unperturbed and disrupted S phases . . . 801
Alejandra Tomas and
Clare Futter and
Stephen E. Moss Annexin 11 is required for midbody
formation and completion of the terminal
phase of cytokinesis . . . . . . . . . . 813
Andreas Marg and
Ying Shan and
Thomas Meyer and
Torsten Meissner and
Martin Brandenburg and
Uwe Vinkemeier Nucleocytoplasmic shuttling by
nucleoporins Nup153 and Nup214 and
CRM1-dependent nuclear export control
the subcellular distribution of latent
Stat1 . . . . . . . . . . . . . . . . . 823
Paul G. Ekert and
Stuart H. Read and
John Silke and
Vanessa S. Marsden and
Hitto Kaufmann and
Christine J. Hawkins and
Robert Gerl and
Sharad Kumar and
David L. Vaux Apaf-1 and caspase-9 accelerate
apoptosis, but do not determine whether
factor-deprived or drug-treated cells
die . . . . . . . . . . . . . . . . . . 835
Jianying Luo and
Elizabeth A. Vallen and
Christopher Dravis and
Serguei E. Tcheperegine and
Becky Drees and
Erfei Bi Identification and functional analysis
of the essential and regulatory light
chains of the only type II myosin Myo1p
in \bionameSaccharomyces cerevisiae . . 843
Limor Broday and
Irina Kolotuev and
Christine Didier and
Anindita Bhoumik and
Benjamin Podbilewicz and
Ze'ev Ronai The LIM domain protein UNC-95 is
required for the assembly of muscle
attachment structures and is regulated
by the RING finger protein RNF-5 in
\bionameC. elegans . . . . . . . . . . . 857
Jakub M. Swiercz and
Rohini Kuner and
Stefan Offermanns Plexin--B1\slash RhoGEF-mediated RhoA
activation involves the receptor
tyrosine kinase ErbB-2 . . . . . . . . . 869
Jianbo Yang and
Matthew A. Price and
Cheryl L. Neudauer and
Christopher Wilson and
Soldano Ferrone and
Hong Xia and
Joji Iida and
Melanie A. Simpson and
James B. McCarthy Melanoma chondroitin sulfate
proteoglycan enhances FAK and ERK
activation by distinct mechanisms . . . 881
Osamu Nagano and
Daizo Murakami and
Dieter Hartmann and
Bart de Strooper and
Paul Saftig and
Takeshi Iwatsubo and
Motowo Nakajima and
Masanori Shinohara and
Hideyuki Saya Cell--matrix interaction via CD44 is
independently regulated by different
metalloproteinases activated in response
to extracellular Ca$^{2+}$ influx and
PKC activation . . . . . . . . . . . . . 893
Aparna Sreenivasan Fusion at the front . . . . . . . . . . ??
Aparna Sreenivasan Anti-angiogenesis is anti-actin . . . . ??
Aparna Sreenivasan Calcium signals from outside . . . . . . ??
Aparna Sreenivasan Myelin movement . . . . . . . . . . . . ??
Aparna Sreenivasan Orbit(ing) the furrow . . . . . . . . . ??
William A. Wells Moving while sticking . . . . . . . . . ??
William A. Wells How a channel springs open . . . . . . . ??
William A. Wells Caterpillar compaction . . . . . . . . . ??
William A. Wells A message before dying . . . . . . . . . ??
William A. Wells Prions in packages . . . . . . . . . . . ??
Mike Rossner and
Kenneth M. Yamada What's in a picture? The temptation of
image manipulation . . . . . . . . . . . 11
Toshiaki Sakisaka and
Takeshi Baba and
Shintaro Tanaka and
Genkichi Izumi and
Masato Yasumi and
Yoshimi Takai Regulation of SNAREs by tomosyn and ROCK 17
Vincent van den Boom and
Elisabetta Citterio and
Deborah Hoogstraten and
Angelika Zotter and
Jean-Marc Egly and
Wiggert A. van Cappellen and
Jan H. J. Hoeijmakers and
Adriaan B. Houtsmuller and
Wim Vermeulen DNA damage stabilizes interaction of CSB
with the transcription elongation
machinery . . . . . . . . . . . . . . . 27
Philippe Blache and
Marc van de Wetering and
Isabelle Duluc and
Claire Domon and
Philippe Berta and
Jean-Noël Freund and
Hans Clevers and
Philippe Jay SOX9 is an intestine crypt transcription
factor, is regulated by the Wnt pathway,
and represses the CDX2 and MUC2 genes 37
Yoshihiro H. Inoue and
Matthew S. Savoian and
Takao Suzuki and
Endre Máthé and
Masa-Toshi Yamamoto and
David M. Glover Mutations in orbit/mast reveal that the
central spindle is comprised of two
microtubule populations, those that
initiate cleavage and those that
propagate furrow ingression . . . . . . 49
Pier Paolo D'Avino and
Matthew S. Savoian and
David M. Glover Mutations in sticky lead to defective
organization of the contractile ring
during cytokinesis and are enhanced by
Rho and suppressed by Rac . . . . . . . 61
Neetu Gupta-Rossi and
Emmanuelle Six and
Odile LeBail and
Frédérique Logeat and
Patricia Chastagner and
Annie Olry and
Alain Israël and
Christel Brou Monoubiquitination and endocytosis
direct $ \gamma $-secretase cleavage of
activated Notch receptor . . . . . . . . 73
Takashi Fujita and
Yasutaka Azuma and
Ryo Fukuyama and
Yuji Hattori and
Carolina Yoshida and
Masao Koida and
Kiyokazu Ogita and
Toshihisa Komori Runx2 induces osteoblast and chondrocyte
differentiation and enhances their
migration by coupling with PI3K--Akt
signaling . . . . . . . . . . . . . . . 85
Gregory Bix and
Jian Fu and
Eva M. Gonzalez and
Laura Macro and
Amy Barker and
Shelly Campbell and
Mary M. Zutter and
Samuel A. Santoro and
Jiyeun K. Kim and
Magnus Höök and
Charles C. Reed and
Renato V. Iozzo Endorepellin causes endothelial cell
disassembly of actin cytoskeleton and
focal adhesions through $ \alpha $2$
\beta $1 integrin . . . . . . . . . . . 97
Rosa Caroppo and
Andrea Gerbino and
Gregorio Fistetto and
Matilde Colella and
Lucantonio Debellis and
Aldebaran M. Hofer and
Silvana Curci Extracellular calcium acts as a ``third
messenger'' to regulate enzyme and
alkaline secretion . . . . . . . . . . . 111
Julia M. Edgar and
Mark McLaughlin and
Donald Yool and
Su-Chun Zhang and
Jill H. Fowler and
Paul Montague and
Jennifer A. Barrie and
Mailis C. McCulloch and
Ian D. Duncan and
James Garbern and
Klaus A. Nave and
Ian R. Griffiths Oligodendroglial modulation of fast
axonal transport in a mouse model of
hereditary spastic paraplegia . . . . . 121
Janice Murtagh and
Emmett McArdle and
Emer Gilligan and
Laura Thornton and
Fiona Furlong and
Finian Martin Organization of mammary epithelial cells
into $3$D acinar structures requires
glucocorticoid and JNK signaling . . . . 133
Nicole LeBrasseur A synaptic scaffold quiets T cells . . . ??
Nicole LeBrasseur Another passenger on chromosomes . . . . ??
Nicole LeBrasseur Loopy for telomeres . . . . . . . . . . ??
Nicole LeBrasseur Integrins talk to N-cadherin . . . . . . ??
Nicole LeBrasseur E-cadherin evades endocytosis . . . . . ??
William A. Wells Cohesin gets pushed around . . . . . . . ??
William A. Wells Flat-out pushing by actin . . . . . . . ??
William A. Wells Xylogen makes plant channels . . . . . . ??
William A. Wells Mini inhibition . . . . . . . . . . . . ??
William A. Wells Reprogramming by virus . . . . . . . . . ??
Michael D. Schaller FAK and paxillin . . . . . . . . . . . . 157
Tatiana Nikitina and
Christopher L. Woodcock Closed chromatin loops at the ends of
chromosomes . . . . . . . . . . . . . . 161
Ulrike Gruneberg and
Rüdiger Neef and
Reiko Honda and
Erich A. Nigg and
Francis A. Barr Relocation of Aurora B from centromeres
to the central spindle at the metaphase
to anaphase transition requires MKlp2 167
Ramnik Xavier and
Shahrooz Rabizadeh and
Kazuhiro Ishiguro and
Niko Andre and
J. Bernabe Ortiz and
Heather Wachtel and
David G. Morris and
Marco Lopez-Ilasaca and
Albert C. Shaw and
Wojciech Swat and
Brian Seed Discs large (Dlg1) complexes in
lymphocyte activation . . . . . . . . . 173
Reto Gassmann and
Ana Carvalho and
Alexander J. Henzing and
Sandrine Ruchaud and
Damien F. Hudson and
Reiko Honda and
Erich A. Nigg and
Dietlind L. Gerloff and
William C. Earnshaw Borealin . . . . . . . . . . . . . . . . 179
Rui Chen and
Ignacio Valencia and
Fei Zhong and
Karen S. McColl and
H. Llewelyn Roderick and
Martin D. Bootman and
Michael J. Berridge and
Stuart J. Conway and
Andrew B. Holmes and
Gregory A. Mignery and
Patricio Velez and
Clark W. Distelhorst Bcl-2 functionally interacts with
inositol 1,4,5-trisphosphate receptors
to regulate calcium release from the ER
in response to inositol
1,4,5-trisphosphate . . . . . . . . . . 193
Prasenjit Mitra and
Yingjie Zhang and
Lucia E. Rameh and
Maria P. Ivshina and
Dannel McCollum and
John J. Nunnari and
Gregory M. Hendricks and
Monica L. Kerr and
Seth J. Field and
Lewis C. Cantley and
Alonzo H. Ross A novel phosphatidylinositol(3,4,5)P$_3$
pathway in fission yeast . . . . . . . . 205
Laura S. Harrington and
Greg M. Findlay and
Alex Gray and
Tatiana Tolkacheva and
Simon Wigfield and
Heike Rebholz and
Jill Barnett and
Nick R. Leslie and
Susan Cheng and
Peter R. Shepherd and
Ivan Gout and
C. Peter Downes and
Richard F. Lamb The TSC1-2 tumor suppressor controls
insulin--PI3K signaling via regulation
of IRS proteins . . . . . . . . . . . . 213
Laurence Bougn\`eres and
Stéphane E. Girardin and
Scott A. Weed and
Andrei V. Karginov and
Jean-Christophe Olivo-Marin and
J. Thomas Parsons and
Philippe J. Sansonetti and
Guy Tran Van Nhieu Cortactin and Crk cooperate to trigger
actin polymerization during Shigella
invasion of epithelial cells . . . . . . 225
Genkichi Izumi and
Toshiaki Sakisaka and
Takeshi Baba and
Shintaro Tanaka and
Koji Morimoto and
Yoshimi Takai Endocytosis of E-cadherin regulated by
Rac and Cdc42 small G proteins through
IQGAP1 and actin filaments . . . . . . . 237
Bill Adolfsen and
Sudipta Saraswati and
Motojiro Yoshihara and
J. Troy Littleton Synaptotagmins are trafficked to
distinct subcellular domains including
the postsynaptic compartment . . . . . . 249
Alex I. Chernyavsky and
Juan Arredondo and
Jürgen Wess and
Evert Karlsson and
Sergei A. Grando Novel signaling pathways mediating
reciprocal control of keratinocyte
migration and wound epithelialization
through M$_3$ and M$_4$ muscarinic
receptors . . . . . . . . . . . . . . . 261
M. Angelica Martinez Gakidis and
Xavier Cullere and
Timothy Olson and
Julie L. Wilsbacher and
Bin Zhang and
Sheri L. Moores and
Klaus Ley and
Wojciech Swat and
Tanya Mayadas and
Joan S. Brugge Vav GEFs are required for $ \beta_2 $
integrin-dependent functions of
neutrophils . . . . . . . . . . . . . . 273
Hajime Yano and
Yuichi Mazaki and
Kazuo Kurokawa and
Steven K. Hanks and
Michiyuki Matsuda and
Hisataka Sabe Roles played by a subset of integrin
signaling molecules in cadherin-based
cell--cell adhesion . . . . . . . . . . 283
William A. Wells A muscular path to quiescence . . . . . ??
William A. Wells Do yeast apoptose? . . . . . . . . . . . ??
William A. Wells Integrins make a choice . . . . . . . . ??
William A. Wells Freedom from substrate . . . . . . . . . ??
William A. Wells Rho in podosomes . . . . . . . . . . . . ??
Nicole LeBrasseur BARS takes Golgi apart . . . . . . . . . ??
Nicole LeBrasseur With their dying breath . . . . . . . . ??
Nicole LeBrasseur Arp2\slash 3 for axon turning . . . . . ??
Nicole LeBrasseur Death takes a holiday . . . . . . . . . ??
Nicole LeBrasseur Running Mad-ly into mitosis . . . . . . ??
Nicole LeBrasseur West Meets East . . . . . . . . . . . . 308
Robert Wysocki and
Stephen J. Kron Yeast cell death during DNA damage
arrest is independent of caspase or
reactive oxygen species . . . . . . . . 311
Rebecca L. Berdeaux and
Begoña Díaz and
Lomi Kim and
G. Steven Martin Active Rho is localized to podosomes
induced by oncogenic Src and is required
for their assembly and function . . . . 317
Charissa D. Ellis and
Fudi Wang and
Colin W. MacDiarmid and
Suzanne Clark and
Thomas Lyons and
David J. Eide Zinc and the Msc2 zinc transporter
protein are required for endoplasmic
reticulum function . . . . . . . . . . . 325
Henrik Òstergaard and
Christine Tachibana and
Jakob R. Winther Monitoring disulfide bond formation in
the eukaryotic cytosol . . . . . . . . . 337
Peter S. Zammit and
Jon P. Golding and
Yosuke Nagata and
Valérie Hudon and
Terence A. Partridge and
Jonathan R. Beauchamp Muscle satellite cells adopt divergent
fates . . . . . . . . . . . . . . . . . 347
Stefan Liebner and
Anna Cattelino and
Radiosa Gallini and
Noemi Rudini and
Monica Iurlaro and
Stefano Piccolo and
Elisabetta Dejana $ \beta $-Catenin is required for
endothelial-mesenchymal transformation
during heart cushion development in the
mouse . . . . . . . . . . . . . . . . . 359
Sebastian Kreuz and
Daniela Siegmund and
Jost-Julian Rumpf and
Dierk Samel and
Martin Leverkus and
Ottmar Janssen and
Georg Häcker and
Oliver Dittrich-Breiholz and
Michael Kracht and
Peter Scheurich and
Harald Wajant NF$ \kappa $B activation by Fas is
mediated through FADD, caspase-8, and
RIP and is inhibited by FLIP . . . . . . 369
Rachelle E. Toman and
Shawn G. Payne and
Kenneth R. Watterson and
Michael Maceyka and
Norman H. Lee and
Sheldon Milstien and
John W. Bigbee and
Sarah Spiegel Differential transactivation of
sphingosine-$1$-phosphate receptors
modulates NGF-induced neurite extension 381
Tatsuro Fukuhara and
Kazuya Shimizu and
Tomomi Kawakatsu and
Taihei Fukuyama and
Yukiko Minami and
Tomoyuki Honda and
Takashi Hoshino and
Tomohiro Yamada and
Hisakazu Ogita and
Masato Okada and
Yoshimi Takai Activation of Cdc42 by trans
interactions of the cell adhesion
molecules nectins through c--Src and
Cdc42-GEF FRG . . . . . . . . . . . . . 393
Hira Lal Goel and
Mara Fornaro and
Loredana Moro and
Natalia Teider and
Johng S. Rhim and
Michael King and
Lucia R. Languino Selective modulation of type 1
insulin-like growth factor receptor
signaling and functions by $ \beta_1 $
integrins . . . . . . . . . . . . . . . 407
Sam M. Janes and
Fiona M. Watt Switch from $ \alpha $v$ \beta $5 to $
\alpha $v$ \beta $6 integrin expression
protects squamous cell carcinomas from
anoikis . . . . . . . . . . . . . . . . 419
Yanzhuang Wang and
Ayano Satoh and
Graham Warren and
Hemmo H. Meyer Correction . . . . . . . . . . . . . . . 433
Nicole LeBrasseur No endocytosis in the axonal entry . . . ??
Nicole LeBrasseur Antagonizing T cells . . . . . . . . . . ??
Nicole LeBrasseur Kif2a cures monopolar disorder . . . . . ??
Nicole LeBrasseur Ubiquitin stripping . . . . . . . . . . ??
Nicole LeBrasseur Collagen for swallowing . . . . . . . . ??
William A. Wells Bugs to the rescue . . . . . . . . . . . ??
William A. Wells Protein-only prions . . . . . . . . . . ??
William A. Wells Channels rush in . . . . . . . . . . . . ??
William A. Wells Corralled by septin . . . . . . . . . . ??
William A. Wells License to glue . . . . . . . . . . . . ??
Yoshikazu Imanishi and
Volker Gerke and
Krzysztof Palczewski Retinosomes . . . . . . . . . . . . . . 447
David A. Solomon and
M. Cristina Cardoso and
Erik S. Knudsen Dynamic targeting of the replication
machinery to sites of DNA damage . . . . 455
Jedidiah Gaetz and
Tarun M. Kapoor Dynein\slash dynactin regulate metaphase
spindle length by targeting
depolymerizing activities to spindle
poles . . . . . . . . . . . . . . . . . 465
Neil J. Ganem and
Duane A. Compton The KinI kinesin Kif2a is required for
bipolar spindle assembly through a
functional relationship with MCAK . . . 473
Nam-On Ku and
Haian Fu and
M. Bishr Omary Raf-1 activation disrupts its binding to
keratins during cell stress . . . . . . 479
John McCullough and
Michael J. Clague and
Sylvie Urbé AMSH is an endosome-associated ubiquitin
isopeptidase . . . . . . . . . . . . . . 487
Mounia Guenatri and
Delphine Bailly and
Christ\`ele Maison and
Genevi\`eve Almouzni Mouse centric and pericentric satellite
repeats form distinct functional
heterochromatin . . . . . . . . . . . . 493
Takahiro Matsusaka and
Jonathon Pines Chfr acts with the p38 stress kinases to
block entry to mitosis in mammalian
cells . . . . . . . . . . . . . . . . . 507
Alexei Mikhailov and
Mio Shinohara and
Conly L. Rieder Topoisomerase II and histone deacetylase
inhibitors delay the G2/M transition by
triggering the p38 MAPK checkpoint
pathway . . . . . . . . . . . . . . . . 517
Rüdiger Rudolf and
Marco Mongillo and
Paulo J. Magalhães and
Tullio Pozzan In vivo monitoring of Ca$^{2+}$ uptake
into mitochondria of mouse skeletal
muscle during contraction . . . . . . . 527
Susan Treves and
Clara Franzini-Armstrong and
Luca Moccagatta and
Christophe Arnoult and
Cristiano Grasso and
Adam Schrum and
Sylvie Ducreux and
Michael X. Zhu and
Katsuhiko Mikoshiba and
Thierry Girard and
Sophia Smida-Rezgui and
Michel Ronjat and
Francesco Zorzato Junctate is a key element in calcium
entry induced by activation of InsP$_3$
receptors and/or calcium store depletion 537
Sol Sotillos and
María Teresa Díaz-Meco and
Eva Caminero and
Jorge Moscat and
Sonsoles Campuzano DaPKC-dependent phosphorylation of
Crumbs is required for epithelial cell
polarity in \bionameDrosophila . . . . . 549
Shin-ichiro Kitajiri and
Kanehisa Fukumoto and
Masaki Hata and
Hiroyuki Sasaki and
Tatsuya Katsuno and
Takayuki Nakagawa and
Juichi Ito and
Shoichiro Tsukita and
Sachiko Tsukita Radixin deficiency causes deafness
associated with progressive degeneration
of cochlear stereocilia . . . . . . . . 559
Marie-Pierre Fache and
Anissa Moussif and
Fanny Fernandes and
Pierre Giraud and
Juan José Garrido and
Bénédicte Dargent Endocytotic elimination and
domain-selective tethering constitute a
potential mechanism of protein
segregation at the axonal initial
segment . . . . . . . . . . . . . . . . 571
Cenk Sumen and
Michael L. Dustin and
Mark M. Davis T cell receptor antagonism interferes
with MHC clustering and integrin
patterning during immunological synapse
formation . . . . . . . . . . . . . . . 579
Hideaki Sumiyoshi and
Niv Mor and
Sui Y. Lee and
Stephen Doty and
Scott Henderson and
Shizuko Tanaka and
Hidekatsu Yoshioka and
Satish Rattan and
Francesco Ramirez Esophageal muscle physiology and
morphogenesis require assembly of a
collagen XIX--rich basement membrane
zone . . . . . . . . . . . . . . . . . . 591
Manjari Mazumdar and
Suma Sundareshan and
Tom Misteli Human chromokinesin KIF4A functions in
chromosome condensation and segregation 613
Daigo Ishikawa and
Hayashi Yamamoto and
Yasushi Tamura and
Kaori Moritoh and
Toshiya Endo Two novel proteins in the mitochondrial
outer membrane mediate $ \beta $-barrel
protein assembly . . . . . . . . . . . . 621
Michael E. Young and
John A. Cooper and
Paul C. Bridgman Yeast actin patches are networks of
branched actin filaments . . . . . . . . 629
Agata Jurczyk and
Adam Gromley and
Sambra Redick and
Jovenal San Agustin and
George Witman and
Gregory J. Pazour and
Dorien J. M. Peters and
Stephen Doxsey Pericentrin forms a complex with
intraflagellar transport proteins and
polycystin-2 and is required for primary
cilia assembly . . . . . . . . . . . . . 637
Laurence Abrami and
Margaret Lindsay and
Robert G. Parton and
Stephen H. Leppla and
F. Gisou van der Goot Membrane insertion of anthrax protective
antigen and cytoplasmic delivery of
lethal factor occur at different stages
of the endocytic pathway . . . . . . . . 645
Karen R. Groot and
Lisa M. Sevilla and
Kazunori Nishi and
Teresa DiColandrea and
Fiona M. Watt Kazrin, a novel periplakin-interacting
protein associated with desmosomes and
the keratinocyte plasma membrane . . . . 653
Violaine Sée and
Nina K. M. Rajala and
David G. Spiller and
Michael R. H. White Calcium-dependent regulation of the cell
cycle via a novel MAPK-NF-$ \kappa $B
pathway in Swiss 3T3 cells . . . . . . . 661
Ming Fu and
Vincent Chi Hang Lui and
Mai Har Sham and
Vassilis Pachnis and
Paul Kwong Hang Tam Sonic hedgehog regulates the
proliferation, differentiation, and
migration of enteric neural crest cells
in gut . . . . . . . . . . . . . . . . . 673
Anthony J. Kee and
Galina Schevzov and
Visalini Nair-Shalliker and
C. Stephen Robinson and
Bernadette Vrhovski and
Majid Ghoddusi and
Min Ru Qiu and
Jim J.-C. Lin and
Ron Weinberger and
Peter W. Gunning and
Edna C. Hardeman Sorting of a nonmuscle tropomyosin to a
novel cytoskeletal compartment in
skeletal muscle results in muscular
dystrophy . . . . . . . . . . . . . . . 685
Ghassan Mouneimne and
Lilian Soon and
Vera DesMarais and
Mazen Sidani and
Xiaoyan Song and
Shu-Chin Yip and
Mousumi Ghosh and
Robert Eddy and
Jonathan M. Backer and
John Condeelis Phospholipase C and cofilin are required
for carcinoma cell directionality in
response to EGF stimulation . . . . . . 697
David R. Mitchell and
Masako Nakatsugawa Bend propagation drives central pair
rotation in Chlamydomonas reinhardtii
flagella . . . . . . . . . . . . . . . . 709
Natalie Luhtala and
Greg Odorizzi Bro1 coordinates deubiquitination in the
multivesicular body pathway by
recruiting Doa4 to endosomes . . . . . . 717
Nicole Schaeren-Wiemers and
Annick Bonnet and
Michael Erb and
Beat Erne and
Udo Bartsch and
Frances Kern and
Ned Mantei and
Diane Sherman and
Ueli Suter The raft-associated protein MAL is
required for maintenance of proper
axon--glia interactions in the central
nervous system . . . . . . . . . . . . . 731
Stéphanie Seveau and
Hél\`ene Bierne and
Stéphanie Giroux and
Marie-Christine Prévost and
Pascale Cossart Role of lipid rafts in E-cadherin- and
HGF-R/Met-mediated entry of
\bioname\bionameListeria monocytogenes
into host cells . . . . . . . . . . . . 743
Rabiya Tuma Actin branches out in yeast . . . . . . ??
Rabiya Tuma Less kinesin, more condensation . . . . ??
Rabiya Tuma Calcium lights up cell cycle . . . . . . ??
Rabiya Tuma Flagellar microtubules do the twist . . ??
Rabiya Tuma Pericentrin pivotal in primary cilia . . ??
Nicole LeBrasseur Swelling with tumors . . . . . . . . . . ??
Nicole LeBrasseur Shh is out on a limb . . . . . . . . . . ??
Nicole LeBrasseur Ping pong in the pore . . . . . . . . . ??
Nicole LeBrasseur Division at right angles . . . . . . . . ??
Nicole LeBrasseur Getting to the inner circle . . . . . . ??
Ralph M. Steinman and
Ira Mellman The JEM and the JCB . . . . . . . . . . 611
Natashe Kireeva and
Margot Lakonishok and
Igor Kireev and
Tatsuya Hirano and
Andrew S. Belmont Visualization of early chromosome
condensation . . . . . . . . . . . . . . 775
Anthony Kar Lun Leung and
Daniel Gerlich and
Gail Miller and
Carol Lyon and
Yun Wah Lam and
David Lleres and
Nathalie Daigle and
Joost Zomerdijk and
Jan Ellenberg and
Angus I. Lamond Quantitative kinetic analysis of
nucleolar breakdown and reassembly
during mitosis in live human cells . . . 787
Sagar Sengupta and
Ana I. Robles and
Steven P. Linke and
Natasha I. Sinogeeva and
Ran Zhang and
Remy Pedeux and
Irene M. Ward and
Arkady Celeste and
André Nussenzweig and
Junjie Chen and
Thanos D. Halazonetis and
Curtis C. Harris Functional interaction between BLM
helicase and 53BP1 in a Chk1-mediated
pathway during S-phase arrest . . . . . 801
Daniele Zink and
Margarida D. Amaral and
Andreas Englmann and
Susanne Lang and
Luka A. Clarke and
Carsten Rudolph and
Felix Alt and
Kathrin Luther and
Carla Braz and
Nicolas Sadoni and
Joseph Rosenecker and
Dirk Schindelhauer Transcription-dependent spatial
arrangements of CFTR and adjacent genes
in human cell nuclei . . . . . . . . . . 815
Christopher E. Andoniou and
Daniel M. Andrews and
Mitali Manzur and
Paola Ricciardi-Castagnoli and
Mariapia A. Degli-Esposti A novel checkpoint in the
Bcl-2--regulated apoptotic pathway
revealed by murine cytomegalovirus
infection of dendritic cells . . . . . . 827
M. Bentele and
I. Lavrik and
M. Ulrich and
S. Stößer and
D. W. Heermann and
H. Kalthoff and
P. H. Krammer and
R. Eils Mathematical modeling reveals threshold
mechanism in CD95-induced apoptosis . . 839
Jacqueline L. Vanderluit and
Kerry L. Ferguson and
Vassiliki Nikoletopoulou and
Maura Parker and
Vladimir Ruzhynsky and
Tania Alexson and
Stephen M. McNamara and
David S. Park and
Michael Rudnicki and
Ruth S. Slack p107 regulates neural precursor cells in
the mammalian brain . . . . . . . . . . 853
Michael S. Huh and
Maura H. Parker and
Anthony Scim\`e and
Robin Parks and
Michael A. Rudnicki Rb is required for progression through
myogenic differentiation but not
maintenance of terminal differentiation 865
Adam J. Engler and
Maureen A. Griffin and
Shamik Sen and
Carsten G. Bönnemann and
H. Lee Sweeney and
Dennis E. Discher Myotubes differentiate optimally on
substrates with tissue-like stiffness 877
Roland Wedlich-Soldner and
Stephanie C. Wai and
Thomas Schmidt and
Rong Li Robust cell polarity is a dynamic state
established by coupling transport and
GTPase signaling . . . . . . . . . . . . 889
Dominic M. Clarke and
Michael C. Brown and
David P. LaLonde and
Christopher E. Turner Phosphorylation of actopaxin regulates
cell spreading and migration . . . . . . 901
Tadayuki Yago and
Jianhua Wu and
C. Diana Wey and
Arkadiusz G. Klopocki and
Cheng Zhu and
Rodger P. McEver Catch bonds govern adhesion through
L-selectin at threshold shear . . . . . 913
Nicole LeBrasseur Best stiffness for striation . . . . . . ??
Nicole LeBrasseur A model of cell death . . . . . . . . . ??
Nicole LeBrasseur Hitched genes still independent . . . . ??
Nicole LeBrasseur Forced to bond . . . . . . . . . . . . . ??
Nicole LeBrasseur Condensation by folding . . . . . . . . ??
William A. Wells Structure with a light touch . . . . . . ??
William A. Wells Tumors need less regulation . . . . . . ??
William A. Wells Dystrophic muscles get overexcited . . . ??
William A. Wells Slow but steady wins the drug race . . . ??
William A. Wells Clathrin starts off alone . . . . . . . ??
Said Hashemolhosseini and
Michael Wegner Impacts of a new transcription factor
family . . . . . . . . . . . . . . . . . 765
Ross E. Dalbey and
Andreas Kuhn YidC family members are involved in the
membrane insertion, lateral integration,
folding, and assembly of membrane
proteins . . . . . . . . . . . . . . . . 769
Nicole LeBrasseur Correction . . . . . . . . . . . . . . . 925
Takao Setoguchi and
Toru Kondo Nuclear export of OLIG2 in neural stem
cells is essential for ciliary
neurotrophic factor--induced astrocyte
differentiation . . . . . . . . . . . . 963
Silke Wissing and
Paula Ludovico and
Eva Herker and
Sabrina Büttner and
Silvia M. Engelhardt and
Thorsten Decker and
Alexander Link and
Astrid Proksch and
Fernando Rodrigues and
Manuela Corte-Real and
Kai-Uwe Fröhlich and
Joachim Manns and
Céline Candé and
Stephan J. Sigrist and
Guido Kroemer and
Frank Madeo An AIF orthologue regulates apoptosis in
yeast . . . . . . . . . . . . . . . . . 969
Chiemi Miyagi and
Susumu Yamashita and
Yusuke Ohba and
Hisayoshi Yoshizaki and
Michiyuki Matsuda and
Toshio Hirano STAT3 noncell-autonomously controls
planar cell polarity during zebrafish
convergence and extension . . . . . . . 975
Sandra Lacas-Gervais and
Jun Guo and
Nicola Strenzke and
Eric Scarfone and
Melanie Kolpe and
Monika Jahkel and
Pietro De Camilli and
Tobias Moser and
Matthew N. Rasband and
Michele Solimena $ \beta $IV$ \sigma $1 spectrin
stabilizes the nodes of Ranvier and axon
initial segments . . . . . . . . . . . . 983
James Powers and
Debra J. Rose and
Adam Saunders and
Steven Dunkelbarger and
Susan Strome and
William M. Saxton Loss of KLP-19 polar ejection force
causes misorientation and missegregation
of holocentric chromosomes . . . . . . . 991
Gideon Lansbergen and
Yulia Komarova and
Mauro Modesti and
Claire Wyman and
Casper C. Hoogenraad and
Holly V. Goodson and
Régis P. Lemaitre and
David N. Drechsel and
Erik van Munster and
Theodorus W. J. Gadella and
Frank Grosveld and
Niels Galjart and
Gary G. Borisy and
Anna Akhmanova Conformational changes in CLIP-170
regulate its binding to microtubules and
dynactin localization . . . . . . . . . 1003
David Stan\vek and
Karla M. Neugebauer Detection of snRNP assembly
intermediates in Cajal bodies by
fluorescence resonance energy transfer 1015
Mariusz Karbowski and
Seon-Yong Jeong and
Richard J. Youle Endophilin B1 is required for the
maintenance of mitochondrial morphology 1027
Cary Esselens and
Viola Oorschot and
Veerle Baert and
Tim Raemaekers and
Kurt Spittaels and
Lutgarde Serneels and
Hui Zheng and
Paul Saftig and
Bart De Strooper and
Judith Klumperman and
Wim Annaert Presenilin 1 mediates the turnover of
telencephalin in hippocampal neurons via
an autophagic degradative pathway . . . 1041
Paola Fabrizio and
Luisa Battistella and
Raffaello Vardavas and
Cristina Gattazzo and
Lee-Loung Liou and
Alberto Diaspro and
Janis W. Dossen and
Edith Butler Gralla and
Valter D. Longo Superoxide is a mediator of an
altruistic aging program in
\bionameSaccharomyces cerevisiae . . . . 1055
Keisuke Kamimura and
John M. Rhodes and
Ryu Ueda and
Melissa McNeely and
Deepak Shukla and
Koji Kimata and
Patricia G. Spear and
Nicholas W. Shworak and
Hiroshi Nakato Regulation of Notch signaling by
\bionameDrosophila heparan sulfate 3- O
sulfotransferase . . . . . . . . . . . . 1069
Richard S. Peterson and
Roma A. Andhare and
Kathleen T. Rousche and
Warren Knudson and
Weihua Wang and
Jami B. Grossfield and
Raymond O. Thomas and
Robert E. Hollingsworth and
Cheryl B. Knudson CD44 modulates Smad1 activation in the
BMP-7 signaling pathway . . . . . . . . 1081
Jiro Takito and
Qais Al-Awqati Conversion of ES cells to columnar
epithelia by hensin and to squamous
epithelia by laminin . . . . . . . . . . 1093
Nicole LeBrasseur Yeast apoptosis debate continues . . . . ??
Nicole LeBrasseur A force for holocentrics to reckon with ??
Nicole LeBrasseur Scaffolds from blood to brain . . . . . ??
Nicole LeBrasseur Narcissistic CLIP-170 also attracts
dynactin . . . . . . . . . . . . . . . . ??
Rabiya Tuma Dendritic cells turn traitorous . . . . ??
Rabiya Tuma Centrosomes take sides . . . . . . . . . ??
Rabiya Tuma Crouching dragon guards nascent proteins ??
Rabiya Tuma Sgo stabilizes glue and microtubules . . ??
Rabiya Tuma Astrocytes orchestrate neuronal
synchrony . . . . . . . . . . . . . . . ??
Julie C. Canman and
William A. Wells Rappaport Furrows on Our Minds . . . . . 943
Oliver J. Gruss and
Isabelle Vernos The mechanism of spindle assembly . . . 949
Guillaume Bompard and
Emmanuelle Caron Regulation of WASP/WAVE proteins . . . . 957
Phoebe D. Lu and
Heather P. Harding and
David Ron Translation reinitiation at alternative
open reading frames regulates gene
expression in an integrated stress
response . . . . . . . . . . . . . . . . 27
Rungtawan Sriburi and
Suzanne Jackowski and
Kazutoshi Mori and
Joseph W. Brewer Xbp1 . . . . . . . . . . . . . . . . . . 35
Jennifer R. Morgan and
Gilbert Di Paolo and
Hauke Werner and
Valentina A. Shchedrina and
Marc Pypaert and
Vincent A. Pieribone and
Pietro De Camilli A role for talin in presynaptic function 43
Paula A. Bubulya and
Kannanganattu V. Prasanth and
Thomas J. Deerinck and
Daniel Gerlich and
Joel Beaudouin and
Mark H. Ellisman and
Jan Ellenberg and
David L. Spector Hypophosphorylated SR splicing factors
transiently localize around active
nucleolar organizing regions in
telophase daughter nuclei . . . . . . . 51
Xiaodong Wang and
Jeanne Matteson and
Yu An and
Bryan Moyer and
Jin-San Yoo and
Sergei Bannykh and
Ian A. Wilson and
John R. Riordan and
William E. Balch COPII-dependent export of cystic
fibrosis transmembrane conductance
regulator from the ER uses a di-acidic
exit code . . . . . . . . . . . . . . . 65
Brenton L. Scott and
Jeffrey S. Van Komen and
Hassan Irshad and
Song Liu and
Kirilee A. Wilson and
James A. McNew Sec1p directly stimulates SNARE-mediated
membrane fusion in vitro . . . . . . . . 75
Rebecca L. Frederick and
J. Michael McCaffery and
Kyle W. Cunningham and
Koji Okamoto and
Janet M. Shaw Yeast Miro GTPase, Gem1p, regulates
mitochondrial morphology via a novel
pathway . . . . . . . . . . . . . . . . 87
Eva-Maria Mandelkow and
Edda Thies and
Bernhard Trinczek and
Jacek Biernat and
Eckard Mandelkow MARK\slash PAR1 kinase is a regulator of
microtubule-dependent transport in axons 99
William T. Arthur and
Lawrence A. Quilliam and
Jonathan A. Cooper Rap1 promotes cell spreading by
localizing Rac guanine nucleotide
exchange factors . . . . . . . . . . . . 111
Katri Koli and
Frank Wempe and
Anja Sterner-Kock and
Anna Kantola and
Martina Komor and
Wolf-K. Hofmann and
Harald von Melchner and
Jorma Keski-Oja Disruption of LTBP-4 function reduces
TGF-$ \beta $ activation and enhances
BMP-4 signaling in the lung . . . . . . 123
Tony J. C. Harris and
Mark Peifer Adherens junction-dependent and
-independent steps in the establishment
of epithelial cell polarity in
\bionameDrosophila . . . . . . . . . . . 135
Katja S. Grossmann and
Christine Grund and
Joerg Huelsken and
Martin Behrend and
Bettina Erdmann and
Werner W. Franke and
Walter Birchmeier Requirement of plakophilin 2 for heart
morphogenesis and cardiac junction
formation . . . . . . . . . . . . . . . 149
Chun Chen and
Bradford A. Young and
Catherine S. Coleman and
Anthony E. Pegg and
Dean Sheppard Spermidine\slash spermine
N$^1$-acetyltransferase specifically
binds to the integrin $ \alpha $9
subunit cytoplasmic domain and enhances
cell migration . . . . . . . . . . . . . 161
DeannaLee M. Beauvais and
Brandon J. Burbach and
Alan C. Rapraeger The syndecan-1 ectodomain regulates $
\alpha_v \beta_3 $ integrin activity in
human mammary carcinoma cells . . . . . 171
Nicole LeBrasseur Splicing takes a NAP . . . . . . . . . . ??
Nicole LeBrasseur Export in cystic fibrosis . . . . . . . ??
Nicole LeBrasseur Talin for presynaptic endocytosis . . . ??
Nicole LeBrasseur MARK clears MAP-muddled traffic . . . . ??
Nicole LeBrasseur Polarity precedes adhesion . . . . . . . ??
William A. Wells Rewiring the cell . . . . . . . . . . . ??
William A. Wells Polarization by migration . . . . . . . ??
William A. Wells Flow to the front . . . . . . . . . . . ??
William A. Wells Immune synapses make a choice . . . . . ??
William A. Wells Endocytosis gets squeezed . . . . . . . ??
Ira Mellman Another evolutionary step for the JCB 17
Carolyn J. Lawrence and
R. Kelly Dawe and
Karen R. Christie and
Don W. Cleveland and
Scott C. Dawson and
Sharyn A. Endow and
Lawrence S. B. Goldstein and
Holly V. Goodson and
Nobutaka Hirokawa and
Jonathon Howard and
Russell L. Malmberg and
J. Richard McIntosh and
Harukata Miki and
Timothy J. Mitchison and
Yasushi Okada and
Anireddy S. N. Reddy and
William M. Saxton and
Manfred Schliwa and
Jonathan M. Scholey and
Ronald D. Vale and
Claire E. Walczak and
Linda Wordeman A standardized kinesin nomenclature . . 19
David Ron and
Randolph Y. Hampton Membrane biogenesis and the unfolded
protein response . . . . . . . . . . . . 23
Rabiya Tuma Vesicle biogenesis potentiation . . . . ??
Rabiya Tuma One protein, two pools . . . . . . . . . ??
Rabiya Tuma One cyclin for adult neurogenesis . . . ??
Rabiya Tuma Tugging and pulling in asymmetric cell
divisions . . . . . . . . . . . . . . . ??
Rabiya Tuma Slipping through the middle . . . . . . ??
Nicole LeBrasseur A chaperone feels the heat . . . . . . . ??
Nicole LeBrasseur Cells have a bubbly look . . . . . . . . ??
Nicole LeBrasseur Uncooperative immune cells . . . . . . . ??
Nicole LeBrasseur VASP comet sightings . . . . . . . . . . ??
Nicole LeBrasseur Insulin keeps time . . . . . . . . . . . ??
Dan Lindholm and
Urmas Arumäe Cell differentiation . . . . . . . . . . 193
Uwe Vinkemeier Getting the message across, STAT! Design
principles of a molecular signaling
circuit . . . . . . . . . . . . . . . . 197
Atsuko Kodama and
Terry Lechler and
Elaine Fuchs Coordinating cytoskeletal tracks to
polarize cellular movements . . . . . . 203
Anna Kowalczyk and
Robert K. Filipkowski and
Marcin Rylski and
Grzegorz M. Wilczynski and
Filip A. Konopacki and
Jacek Jaworski and
Maria A. Ciemerych and
Piotr Sicinski and
Leszek Kaczmarek The critical role of cyclin D2 in adult
neurogenesis . . . . . . . . . . . . . . 209
Salvatore Pece and
Michela Serresi and
Elisa Santolini and
Maria Capra and
Esther Hulleman and
Viviana Galimberti and
Stefano Zurrida and
Patrick Maisonneuve and
Giuseppe Viale and
Pier Paolo Di Fiore Loss of negative regulation by Numb over
Notch is relevant to human breast
carcinogenesis . . . . . . . . . . . . . 215
Sara Weis and
Jianhua Cui and
Leo Barnes and
David Cheresh Endothelial barrier disruption by
VEGF-mediated Src activity potentiates
tumor cell extravasation and metastasis 223
Stephen M. Huisman and
Olivia A. M. Bales and
Marie Bertrand and
Monique F. M. A. Smeets and
Steven I. Reed and
Marisa Segal Differential contribution of Bud6p and
Kar9p to microtubule capture and spindle
orientation in S. cerevisiae . . . . . . 231
Jean-Claude Labbé and
Erin K. McCarthy and
Bob Goldstein The forces that position a mitotic
spindle asymmetrically are tethered
until after the time of spindle assembly 245
Amanda K. Wiggins and
Guangwei Wei and
Epaminondas Doxakis and
Connie Wong and
Amy A. Tang and
Keling Zang and
Esther J. Luo and
Rachael L. Neve and
Louis F. Reichardt and
Eric J. Huang Interaction of Brn3a and HIPK2 mediates
transcriptional repression of sensory
neuron survival . . . . . . . . . . . . 257
Rose Tam and
Kelly P. Smith and
Jeanne B. Lawrence The 4q subtelomere harboring the FSHD
locus is specifically anchored with
peripheral heterochromatin unlike most
human telomeres . . . . . . . . . . . . 269
Alison K. Gillingham and
Amy Hin Yan Tong and
Charles Boone and
Sean Munro The GTPase Arf1p and the ER to Golgi
cargo receptor Erv14p cooperate to
recruit the golgin Rud3p to the
cis-Golgi . . . . . . . . . . . . . . . 281
Fubito Nakatsu and
Motohiro Okada and
Fumiaki Mori and
Noriko Kumazawa and
Hiroto Iwasa and
Gang Zhu and
Yasufumi Kasagi and
Haruyuki Kamiya and
Akihiro Harada and
Kazuhiro Nishimura and
Arata Takeuchi and
Taisuke Miyazaki and
Masahiko Watanabe and
Shigeki Yuasa and
Toshiya Manabe and
Koichi Wakabayashi and
Sunao Kaneko and
Takashi Saito and
Hiroshi Ohno Defective function of GABA-containing
synaptic vesicles in mice lacking the
AP-3B clathrin adaptor . . . . . . . . . 293
Kevin M. Wright and
Michael W. Linhoff and
Patrick Ryan Potts and
Mohanish Deshmukh Decreased apoptosome activity with
neuronal differentiation sets the
threshold for strict IAP regulation of
apoptosis . . . . . . . . . . . . . . . 303
Matthew Lord and
Thomas D. Pollard UCS protein Rng3p activates actin
filament gliding by fission yeast
myosin--II . . . . . . . . . . . . . . . 315
Jong-Hwan Lee and
Tomoya Katakai and
Takahiro Hara and
Hiroyuki Gonda and
Manabu Sugai and
Akira Shimizu Roles of p--ERM and Rho--ROCK signaling
in lymphocyte polarity and uropod
formation . . . . . . . . . . . . . . . 327
Cara J. Gottardi and
Barry M. Gumbiner Distinct molecular forms of $ \beta
$-catenin are targeted to adhesive or
transcriptional complexes . . . . . . . 339
Katsuhisa Matsuura and
Hiroshi Wada and
Toshio Nagai and
Yoshihiro Iijima and
Tohru Minamino and
Masanori Sano and
Hiroshi Akazawa and
Jeffery D. Molkentin and
Hiroshi Kasanuki and
Issei Komuro Cardiomyocytes fuse with surrounding
noncardiomyocytes and reenter the cell
cycle . . . . . . . . . . . . . . . . . 351
Holly Colognato and
Shwetha Ramachandrappa and
Inger M. Olsen and
Charles ffrench-Constant Integrins direct Src family kinases to
regulate distinct phases of
oligodendrocyte development . . . . . . 365
Christopher V. Carman and
Timothy A. Springer A transmigratory cup in leukocyte
diapedesis both through individual
vascular endothelial cells and between
them . . . . . . . . . . . . . . . . . . 377
Nicole LeBrasseur Escorting STAT5A . . . . . . . . . . . . ??
Nicole LeBrasseur Expaaaaanded inclusions . . . . . . . . ??
Nicole LeBrasseur Patches ride cables . . . . . . . . . . ??
Nicole LeBrasseur Speed from recycling . . . . . . . . . . ??
Nicole LeBrasseur Wounds quiet basal cells . . . . . . . . ??
William A. Wells Signaling together apart . . . . . . . . ??
William A. Wells Dormant tumors awaken . . . . . . . . . ??
William A. Wells Neurons inch along . . . . . . . . . . . ??
William A. Wells Diabetes as a stress response . . . . . ??
William A. Wells A SNARE for fast endocytosis . . . . . . ??
Brendan D. Manning Balancing Akt with S6K . . . . . . . . . 399
Loretta Dorstyn and
Kathryn Mills and
Yuri Lazebnik and
Sharad Kumar The two cytochrome c species, DC3 and
DC4, are not required for caspase
activation and apoptosis in
\bionameDrosophila cells . . . . . . . . 405
Ilya M. Nasrallah and
Jeremy C. Minarcik and
Jeffrey A. Golden A polyalanine tract expansion in Arx
forms intranuclear inclusions and
results in increased cell death . . . . 411
Grazia Camarda and
Francesca Siepi and
Deborah Pajalunga and
Camilla Bernardini and
Rossella Rossi and
Alessandra Montecucco and
Ettore Meccia and
Marco Crescenzi A pRb-independent mechanism preserves
the postmitotic state in terminally
differentiated skeletal muscle cells . . 417
Emad I. Khater and
Robert E. Sinden and
Johannes T. Dessens A malaria membrane skeletal protein is
essential for normal morphogenesis,
motility, and infectivity of sporozoites 425
Lilia Alberghina and
Riccardo L. Rossi and
Lorenzo Querin and
Valeria Wanke and
Marco Vanoni A cell sizer network involving Cln3 and
Far1 controls entrance into S phase in
the mitotic cycle of budding yeast . . . 433
Yukio Kimata and
Daisuke Oikawa and
Yusuke Shimizu and
Yuki Ishiwata-Kimata and
Kenji Kohno A role for BiP as an adjustor for the
endoplasmic reticulum stress-sensing
protein Ire1 . . . . . . . . . . . . . . 445
Julián Pardo and
Alberto Bosque and
Reina Brehm and
Reinhard Wallich and
Javier Naval and
Arno Müllbacher and
Alberto Anel and
Markus M. Simon Apoptotic pathways are selectively
activated by granzyme A and/or granzyme
B in CTL-mediated target cell lysis . . 457
Christopher C. Williams and
June G. Allison and
Gregory A. Vidal and
Matthew E. Burow and
Barbara S. Beckman and
Luis Marrero and
Frank E. Jones The ERBB4/HER4 receptor tyrosine kinase
regulates gene expression by functioning
as a STAT5A nuclear chaperone . . . . . 469
Carme Sole and
Xavier Dolcet and
Miguel F. Segura and
Humberto Gutierrez and
Maria-Teresa Diaz-Meco and
Raffaella Gozzelino and
Daniel Sanchis and
Jose R. Bayascas and
Carme Gallego and
Jorge Moscat and
Alun M. Davies and
Joan X. Comella The death receptor antagonist FAIM
promotes neurite outgrowth by a
mechanism that depends on ERK and NF-$
\kappa $B signaling . . . . . . . . . . 479
Jong-Sun Kang and
Min-Jeong Yi and
Wei Zhang and
Jessica L. Feinleib and
Francesca Cole and
Robert S. Krauss Netrins and neogenin promote myotube
formation . . . . . . . . . . . . . . . 493
Atsuo T. Sasaki and
Cheryl Chun and
Kosuke Takeda and
Richard A. Firtel Localized Ras signaling at the leading
edge regulates PI3K, cell polarity, and
directional cell movement . . . . . . . 505
Thomas M. Huckaba and
Anna Card Gay and
Luiz Fernando Pantalena and
Hyeong-Cheol Yang and
Liza A. Pon Live cell imaging of the assembly,
disassembly, and actin cable-dependent
movement of endosomes and actin patches
in the budding yeast,
\bionameSaccharomyces cerevisiae . . . . 519
Agnes Lee Ang and
Tomohiko Taguchi and
Stephen Francis and
Heike Fölsch and
Lindsay J. Murrells and
Marc Pypaert and
Graham Warren and
Ira Mellman Recycling endosomes can serve as
intermediates during transport from the
Golgi to the plasma membrane of MDCK
cells . . . . . . . . . . . . . . . . . 531
Lauren R. Strachan and
Maureen L. Condic Cranial neural crest recycle surface
integrins in a substratum-dependent
manner to promote rapid motility . . . . 545
Theresa S. Richards and
Clarence A. Dunn and
William G. Carter and
Marcia L. Usui and
John E. Olerud and
Paul D. Lampe Protein kinase C spatially and
temporally regulates gap junctional
communication during human wound repair
via phosphorylation of connexin43 on
serine368 . . . . . . . . . . . . . . . 555
Neetu Gupta-Rossi and
Emmanuelle Six and
Odile LeBail and
Frédérique Logeat and
Patricia Chastagner and
Annie Olry and
Alain Israël and
Christel Brou Correction . . . . . . . . . . . . . . . 563
Hira Lal Goel and
Mara Fornaro and
Loredana Moro and
Natalia Teider and
Johng S. Rhim and
Michael King and
Lucia R. Languino Correction . . . . . . . . . . . . . . . 565
Xiaodong Wang and
Jeanne Matteson and
Yu An and
Bryan Moyer and
Jin-San Yoo and
Sergei Bannykh and
Ian A. Wilson and
John R. Riordan and
William E. Balch Correction . . . . . . . . . . . . . . . 567
Rabiya Tuma Mitochondria move in on calcium . . . . ??
Rabiya Tuma ES cells without teratomas . . . . . . . ??
Rabiya Tuma Transport if loaded . . . . . . . . . . ??
Rabiya Tuma Invadolysin opens many doors . . . . . . ??
Rabiya Tuma Making a raft with oligomers . . . . . . ??
Nicole LeBrasseur Palindromic protection . . . . . . . . . ??
Nicole LeBrasseur SOS needs help getting active . . . . . ??
Nicole LeBrasseur SNX1 hugs the curves . . . . . . . . . . ??
Nicole LeBrasseur GTPase modes modeled . . . . . . . . . . ??
Nicole LeBrasseur Profilin for processivity . . . . . . . ??
Bryan Zeitler and
Karsten Weis The FG-repeat asymmetry of the nuclear
pore complex is dispensable for bulk
nucleocytoplasmic transport in vivo . . 583
Ian C. Berke and
Thomas Boehmer and
Günter Blobel and
Thomas U. Schwartz Structural and functional analysis of
Nup133 domains reveals modular building
blocks of the nuclear pore complex . . . 591
Devi M. Nair and
P. Edward Purdue and
Paul B. Lazarow Pex7p translocates in and out of
peroxisomes in \bionameSaccharomyces
cerevisiae . . . . . . . . . . . . . . . 599
Xiaolan Zhao and
Chia-Yung Wu and
Günter Blobel Mlp-dependent anchorage and
stabilization of a desumoylating enzyme
is required to prevent clonal lethality 605
Raymond C. Chan and
Aaron F. Severson and
Barbara J. Meyer Condensin restructures chromosomes in
preparation for meiotic divisions . . . 613
Silvia Espejel and
Peter Klatt and
Josiane Ménissier-de Murcia and
Juan Martín-Caballero and
Juana M. Flores and
Guillermo Taccioli and
Gilbert de Murcia and
María A. Blasco Impact of telomerase ablation on
organismal viability, aging, and
tumorigenesis in mice lacking the DNA
repair proteins PARP-1, Ku86, or
DNA--PKcs . . . . . . . . . . . . . . . 627
Akwasi Anyanful and
Kanako Ono and
Robert C. Johnsen and
Hinh Ly and
Victor Jensen and
David L. Baillie and
Shoichiro Ono The RNA-binding protein SUP-12 controls
muscle-specific splicing of the
ADF/cofilin pre-mRNA in \bionameC.
elegans . . . . . . . . . . . . . . . . 639
Scott M. Plafker and
Kendra S. Plafker and
Allan M. Weissman and
Ian G. Macara Ubiquitin charging of human class III
ubiquitin-conjugating enzymes triggers
their nuclear import . . . . . . . . . . 649
Muqing Yi and
David Weaver and
György Hajnóczky Control of mitochondrial motility and
distribution by the calcium signal . . . 661
Brian McHugh and
Sue A. Krause and
Bin Yu and
Anne-Marie Deans and
Sarah Heasman and
Paul McLaughlin and
Margarete M. S. Heck Invadolysin . . . . . . . . . . . . . . 673
Mayya Meriane and
Joseph Tcherkezian and
Christine A. Webber and
Eric I. Danek and
Ibtissem Triki and
Sarah McFarlane and
Evelyne Bloch-Gallego and
Nathalie Lamarche-Vane Phosphorylation of DCC by Fyn mediates
Netrin-1 signaling in growth cone
guidance . . . . . . . . . . . . . . . . 687
Simona Paladino and
Daniela Sarnataro and
Rudolf Pillich and
Simona Tivodar and
Lucio Nitsch and
Chiara Zurzolo Protein oligomerization modulates raft
partitioning and apical sorting of
GPI-anchored proteins . . . . . . . . . 699
Alessandra Bolino and
Annalisa Bolis and
Stefano Carlo Previtali and
Giorgia Dina and
Simona Bussini and
Gabriele Dati and
Stefano Amadio and
Ubaldo Del Carro and
Dolores D. Mruk and
Maria Laura Feltri and
C. Yan Cheng and
Angelo Quattrini and
Lawrence Wrabetz Disruption of Mtmr2 produces CMT4B1-like
neuropathy with myelin outfolding and
impaired spermatogenesis . . . . . . . . 711
Erhard Bieberich and
Jeane Silva and
Guanghu Wang and
Kannan Krishnamurthy and
Brian G. Condie Selective apoptosis of pluripotent mouse
and human stem cells by novel ceramide
analogues prevents teratoma formation
and enriches for neural precursors in ES
cell--derived neural transplants . . . . 723
Richard M. Siegel and
Jagan R. Muppidi and
Malabika Sarker and
Adrian Lobito and
Melinda Jen and
David Martin and
Stephen E. Straus and
Michael J. Lenardo Spots . . . . . . . . . . . . . . . . . 735
Wenjie Bao and
Staffan Strömblad Integrin $ \alpha $v-mediated
inactivation of p53 controls a
MEK1-dependent melanoma cell survival
pathway in three-dimensional collagen 745
Tae-Hwa Chun and
Farideh Sabeh and
Ichiro Ota and
Hedwig Murphy and
Kevin T. McDonagh and
Kenn Holmbeck and
Henning Birkedal-Hansen and
Edward D. Allen and
Stephen J. Weiss MT1-MMP-dependent neovessel formation
within the confines of the
three-dimensional extracellular matrix 757
Farideh Sabeh and
Ichiro Ota and
Kenn Holmbeck and
Henning Birkedal-Hansen and
Paul Soloway and
Milagros Balbin and
Carlos Lopez-Otin and
Steven Shapiro and
Masaki Inada and
Stephen Krane and
Edward Allen and
Duane Chung and
Stephen J. Weiss Tumor cell traffic through the
extracellular matrix is controlled by
the membrane-anchored collagenase
MT1-MMP . . . . . . . . . . . . . . . . 769
Hongjun Liu and
Michelle Mardahl-Dumesnil and
Sean T. Sweeney and
Cahir J. O'Kane and
Sanford I. Bernstein Retraction . . . . . . . . . . . . . . . 783
Alan W. Dove Retraction . . . . . . . . . . . . . . . 785
Nicole LeBrasseur Ameloblastin . . . . . . . . . . . . . . ??
Nicole LeBrasseur Telomeric spindle proteins . . . . . . . ??
Nicole LeBrasseur Death DNase tied down . . . . . . . . . ??
Nicole LeBrasseur Cholesterol prevents Alzheimer's . . . . ??
Nicole LeBrasseur Quick results for thyroid hormone . . . ??
William A. Wells Elimination by shedding . . . . . . . . ??
William A. Wells Rocking on Pins . . . . . . . . . . . . ??
William A. Wells Destroy and localize . . . . . . . . . . ??
William A. Wells Bacteria diversify . . . . . . . . . . . ??
William A. Wells Picking the clathrin lock . . . . . . . ??
Christoph Kaether and
Christian Haass A lipid boundary separates APP and
secretases and limits amyloid $ \beta
$-peptide generation . . . . . . . . . . 809
David T. Miyamoto and
Zachary E. Perlman and
Kendra S. Burbank and
Aaron C. Groen and
Timothy J. Mitchison The kinesin Eg5 drives poleward
microtubule flux in \bionameXenopus
laevis egg extract spindles . . . . . . 813
Lifeng Xu and
Elizabeth H. Blackburn Human Rif1 protein binds aberrant
telomeres and aligns along anaphase
midzone microtubules . . . . . . . . . . 819
Helder Maiato and
Conly L. Rieder and
Alexey Khodjakov Kinetochore-driven formation of
kinetochore fibers contributes to
spindle assembly during animal mitosis 831
Ayumi Yamada and
Brad Duffy and
Jennifer A. Perry and
Sally Kornbluth DNA replication checkpoint control of
Wee1 stability by vertebrate Hsl7 . . . 841
Delphine Lechardeur and
Ming Xu and
Gergely L. Lukacs Contrasting nuclear dynamics of the
caspase-activated DNase (CAD) in
dividing and apoptotic cells . . . . . . 851
Juliette Jouhet and
Eric Maréchal and
Barbara Baldan and
Richard Bligny and
Jacques Joyard and
Maryse A. Block Phosphate deprivation induces transfer
of DGDG galactolipid from chloroplast to
mitochondria . . . . . . . . . . . . . . 863
Andreas Wiederkehr and
Johan-Owen De Craene and
Susan Ferro-Novick and
Peter Novick Functional specialization within a
vesicle tethering complex . . . . . . . 875
Charles Boyd and
Thom Hughes and
Marc Pypaert and
Peter Novick Vesicles carry most exocyst subunits to
exocytic sites marked by the remaining
two subunits, Sec3p and Exo70p . . . . . 889
Jeremiah F. Roeth and
Maya Williams and
Matthew R. Kasper and
Tracey M. Filzen and
Kathleen L. Collins HIV-1 Nef disrupts MHC--I trafficking by
recruiting AP-1 to the MHC--I
cytoplasmic tail . . . . . . . . . . . . 903
Nuttawut Saelim and
Linu M. John and
Jun Wu and
Jeong Soon Park and
Yidong Bai and
Patricia Camacho and
James D. Lechleiter Nontranscriptional modulation of
intracellular Ca$^{2+}$ signaling by
ligand stimulated thyroid hormone
receptor . . . . . . . . . . . . . . . . 915
David M. Thomas and
Sandra A. Johnson and
Natalie A. Sims and
Melanie K. Trivett and
John L. Slavin and
Brian P. Rubin and
Paul Waring and
Grant A. McArthur and
Carl R. Walkley and
Andrew J. Holloway and
Dileepa Diyagama and
Jonathon E. Grim and
Bruce E. Clurman and
David D. L. Bowtell and
Jong-Seo Lee and
Gabriel M. Gutierrez and
Denise M. Piscopo and
Shannon A. Carty and
Philip W. Hinds Terminal osteoblast differentiation,
mediated by runx2 and p27 $^{\rm KIP1}$,
is disrupted in osteosarcoma . . . . . . 925
Michail S. Davidoff and
Ralf Middendorff and
Grigori Enikolopov and
Dieter Riethmacher and
Adolf F. Holstein and
Dieter Müller Progenitor cells of the
testosterone-producing Leydig cells
revealed . . . . . . . . . . . . . . . . 935
Gunnar Schuetz and
Marta Rosário and
Jan Grimm and
Tobias M. Boeckers and
Eckart D. Gundelfinger and
Walter Birchmeier The neuronal scaffold protein Shank3
mediates signaling and biological
function of the receptor tyrosine kinase
Ret in epithelial cells . . . . . . . . 945
Jose Abad-Rodriguez and
Maria Dolores Ledesma and
Katleen Craessaerts and
Simona Perga and
Miguel Medina and
Andre Delacourte and
Colin Dingwall and
Bart De Strooper and
Carlos G. Dotti Neuronal membrane cholesterol loss
enhances amyloid peptide generation . . 953
Ko Okamura and
Hidekazu Tanaka and
Yoshiki Yagita and
Yoshinaga Saeki and
Akihiko Taguchi and
Yasushi Hiraoka and
Ling-Hui Zeng and
David R. Colman and
Naomasa Miki Cadherin activity is required for
activity-induced spine remodeling . . . 961
Satoshi Fukumoto and
Takayoshi Kiba and
Bradford Hall and
Noriyuki Iehara and
Takashi Nakamura and
Glenn Longenecker and
Paul H. Krebsbach and
Antonio Nanci and
Ashok B. Kulkarni and
Yoshihiko Yamada Ameloblastin is a cell adhesion molecule
required for maintaining the
differentiation state of ameloblasts . . 973
Katsuhisa Matsuura and
Hiroshi Wada and
Toshio Nagai and
Yoshihiro Iijima and
Tohru Minamino and
Masanori Sano and
Hiroshi Akazawa and
Jeffery D. Molkentin and
Hiroshi Kasanuki and
Issei Komuro Correction . . . . . . . . . . . . . . . 985
Rabiya Tuma Measuring insulin . . . . . . . . . . . ??
Rabiya Tuma PINCHing together integrins and
signaling . . . . . . . . . . . . . . . ??
Rabiya Tuma Clustering in integrin binding . . . . . ??
Rabiya Tuma Targeting the inner nuclear membrane . . ??
Rabiya Tuma Stick hard, signal fast . . . . . . . . ??
Nicole LeBrasseur Dynamin in fission and fusion . . . . . ??
Nicole LeBrasseur Opening closed pores . . . . . . . . . . ??
Nicole LeBrasseur Insulin breaks hearts . . . . . . . . . ??
Nicole LeBrasseur Time keepers abound . . . . . . . . . . ??
Nicole LeBrasseur Checking in on spindle size . . . . . . ??
Dalu Xu and
Jesse C. Hay Reconstitution of COPII vesicle fusion
to generate a pre-Golgi intermediate
compartment . . . . . . . . . . . . . . 997
Ying Jie Wang and
Wen Hong Li and
Jing Wang and
Ke Xu and
Ping Dong and
Xiang Luo and
Helen L. Yin Critical role of PIP5KI$ \gamma $87 in
InsP$_3$-mediated Ca$^{2+}$ signaling 1005
Michael M. Kozlov and
Alexander D. Bershadsky Processive capping by formin suggests a
force-driven mechanism of actin
polymerization . . . . . . . . . . . . . 1011
Julie L. Kadrmas and
Mark A. Smith and
Kathleen A. Clark and
Stephen M. Pronovost and
Nemone Muster and
John R. Yates and
Mary C. Beckerle The integrin effector PINCH regulates
JNK activity and epithelial migration in
concert with Ras suppressor 1 . . . . . 1019
Kathrin Plath and
Dale Talbot and
Karien M. Hamer and
Arie P. Otte and
Thomas P. Yang and
Rudolf Jaenisch and
Barbara Panning Developmentally regulated alterations in
Polycomb repressive complex 1 proteins
on the inactive X chromosome . . . . . . 1025
Chizuko Tsurumi and
Steffen Hoffmann and
Stephan Geley and
Ralph Graeser and
Zbigniew Polanski The spindle assembly checkpoint is not
essential for CSF arrest of mouse
oocytes . . . . . . . . . . . . . . . . 1037
Tomoyuki Ohba and
Eric C. Schirmer and
Takeharu Nishimoto and
Larry Gerace Energy- and temperature-dependent
transport of integral proteins to the
inner nuclear membrane via the nuclear
pore . . . . . . . . . . . . . . . . . . 1051
Mirko Trajkovski and
Hassan Mziaut and
Anke Altkrüger and
Joke Ouwendijk and
Klaus-Peter Knoch and
Stefan Müller and
Michele Solimena Nuclear translocation of an ICA512
cytosolic fragment couples granule
exocytosis and insulin expression in $
\beta $-cells . . . . . . . . . . . . . 1063
J. Michael Younger and
Hong-Yu Ren and
Liling Chen and
Chun-Yang Fan and
Andrea Fields and
Cam Patterson and
Douglas M. Cyr A foldable CFTR$ \Delta $F508 biogenic
intermediate accumulates upon inhibition
of the Hsc70--CHIP E3 ubiquitin ligase 1075
Rutilio A. Fratti and
Youngsoo Jun and
Alexey J. Merz and
Nathan Margolis and
William Wickner Interdependent assembly of specific
regulatory lipids and membrane fusion
proteins into the vertex ring domain of
docked vacuoles . . . . . . . . . . . . 1087
Marcello Marelli and
Jennifer J. Smith and
Sunhee Jung and
Eugene Yi and
Alexey I. Nesvizhskii and
Rowan H. Christmas and
Ramsey A. Saleem and
Yuen Yi C. Tam and
Andrei Fagarasanu and
David R. Goodlett and
Ruedi Aebersold and
Richard A. Rachubinski and
John D. Aitchison Quantitative mass spectrometry reveals a
role for the GTPase Rho1p in actin
organization on the peroxisome membrane 1099
Sergei A. Kuznetsov and
Mara Riminucci and
Navid Ziran and
Takeo W. Tsutsui and
Alessandro Corsi and
Laura Calvi and
Henry M. Kronenberg and
Ernestina Schipani and
Pamela Gehron Robey and
Paolo Bianco The interplay of osteogenesis and
hematopoiesis . . . . . . . . . . . . . 1113
Thierry Brun and
Isobel Franklin and
Luc St-Onge and
Anna Biason-Lauber and
Eugene J. Schoenle and
Claes B. Wollheim and
Benoit R. Gauthier The diabetes-linked transcription factor
PAX4 promotes $ \beta $-cell
proliferation and survival in rat and
human islets . . . . . . . . . . . . . . 1123
Jennifer Zeitler and
Cynthia P. Hsu and
Heather Dionne and
David Bilder Domains controlling cell polarity and
proliferation in the \bionameDrosophila
tumor suppressor Scribble . . . . . . . 1137
Ranjana Arya and
Vishram Kedar and
Jae Ryoung Hwang and
Holly McDonough and
Hui-Hua Li and
Joan Taylor and
Cam Patterson Muscle ring finger protein-1 inhibits
PKC$ \epsilon $ activation and prevents
cardiomyocyte hypertrophy . . . . . . . 1147
Andrew Devitt and
Kate G. Parker and
Carol Anne Ogden and
Ceri Oldreive and
Michael F. Clay and
Lynsey A. Melville and
Christopher O. Bellamy and
Adam Lacy-Hulbert and
Sophie C. Gangloff and
Sanna M. Goyert and
Christopher D. Gregory Persistence of apoptotic cells without
autoimmune disease or inflammation in
CD14$^{-/} - $ mice . . . . . . . . . . 1161
Elena Goncharova and
Dmitry Goncharov and
Daniel Noonan and
Vera P. Krymskaya TSC2 modulates actin cytoskeleton and
focal adhesion through TSC1-binding
domain and the Rac1 GTPase . . . . . . . 1171
Yeh-Shiu Chu and
William A. Thomas and
Olivier Eder and
Frederic Pincet and
Eric Perez and
Jean Paul Thiery and
Sylvie Dufour Force measurements in
E-cadherin-mediated cell doublets reveal
rapid adhesion strengthened by actin
cytoskeleton remodeling through Rac and
Cdc42 . . . . . . . . . . . . . . . . . 1183
Xiang-Tian Kong and
Fang-Ming Deng and
Ping Hu and
Feng-Xia Liang and
Ge Zhou and
Anna B. Auerbach and
Nancy Genieser and
Peter K. Nelson and
Edith S. Robbins and
Ellen Shapiro and
Bechara Kachar and
Tung-Tien Sun Roles of uroplakins in plaque formation,
umbrella cell enlargement, and urinary
tract diseases . . . . . . . . . . . . . 1195
Shingo Suzuki and
Tadahiro Numakawa and
Kazuhiro Shimazu and
Hisatsugu Koshimizu and
Tomoko Hara and
Hiroshi Hatanaka and
Lin Mei and
Bai Lu and
Masami Kojima BDNF-induced recruitment of TrkB
receptor into neuronal lipid rafts . . . 1205
François Ahimou and
Lee-Peng Mok and
Boris Bardot and
Cedric Wesley The adhesion force of Notch with Delta
and the rate of Notch signaling . . . . 1217
Xiuwei Yang and
Oleg V. Kovalenko and
Wei Tang and
Christoph Claas and
Christopher S. Stipp and
Martin E. Hemler Palmitoylation supports assembly and
function of integrin--tetraspanin
complexes . . . . . . . . . . . . . . . 1231
Minsoo Kim and
Christopher V. Carman and
Wei Yang and
Azucena Salas and
Timothy A. Springer The primacy of affinity over clustering
in regulation of adhesiveness of the
integrin $ \alpha $$_L$ $ \beta_2$ . . . 1241
Brendan D. Manning Correction . . . . . . . . . . . . . . . 1255
Zongbing You and
Daniel Saims and
Shaoqiong Chen and
Zhaocheng Zhang and
Denis C. Guttridge and
Kun-liang Guan and
Ormond A. MacDougald and
Anthony M. C. Brown and
Gerard Evan and
Jan Kitajewski and
Cun-Yu Wang Correction: Wnt signaling promotes
oncogenic transformation by inhibiting
c-Myc-induced apoptosis . . . . . . . . ??